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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Sox7

Z-value: 0.95

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Transcription factors associated with Sox7

Gene Symbol	Gene ID	Gene Info
Sox7 Ensembl NCBI MGI UniProt	ENSMUSG00000063060.5	Sox7

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Sox7	chr14_63941790_63942313	1622	0.359212	-0.43	5.4e-04	Click!
Sox7	chr14_63940714_63941205	2714	0.251160	-0.36	5.1e-03	Click!
Sox7	chr14_63942562_63942943	921	0.561285	-0.31	1.5e-02	Click!
Sox7	chr14_63943010_63944396	30	0.975591	-0.30	1.9e-02	Click!
Sox7	chr14_63941610_63941761	1988	0.307388	-0.22	8.6e-02	Click!

Activity of the Sox7 motif across conditions

Conditions sorted by the z-value of the Sox7 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_112232861_112233588	3.07	Arpp21	cyclic AMP-regulated phosphoprotein, 21	402	0.75
chr6_103513736_103514218	2.77	Chl1	cell adhesion molecule L1-like	2647	0.25
chr2_121803809_121804141	2.65	Frmd5	FERM domain containing 5	2897	0.26
chr4_22483966_22484156	2.32	Pou3f2	POU domain, class 3, transcription factor 2	4305	0.19
chr7_142091808_142093330	2.23	Dusp8	dual specificity phosphatase 8	2703	0.11
chr8_109245493_109246323	2.11	D030068K23Rik	RIKEN cDNA D030068K23 gene	3958	0.33
chr13_84063384_84064052	2.06	Gm17750	predicted gene, 17750	1054	0.58
chr2_97472737_97472888	1.87	Lrrc4c	leucine rich repeat containing 4C	4723	0.34
chr12_86680036_86680970	1.79	Vash1	vasohibin 1	1803	0.28
chr12_26472511_26472823	1.76	Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	1263	0.39
chr1_81077232_81078427	1.71	Nyap2	neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2	246	0.96
chr13_83717521_83718816	1.53	C130071C03Rik	RIKEN cDNA C130071C03 gene	3213	0.17
chr1_6731579_6732076	1.49	St18	suppression of tumorigenicity 18	1725	0.48
chr13_78172031_78172578	1.49	3110006O06Rik	RIKEN cDNA 3110006O06 gene	674	0.61
chr7_61309776_61310205	1.43	A230006K03Rik	RIKEN cDNA A230006K03 gene	1723	0.5
chr4_22497544_22499061	1.42	Gm30731	predicted gene, 30731	7754	0.16
chr12_46817370_46817521	1.41	Nova1	NOVA alternative splicing regulator 1	485	0.82
chr13_21382104_21382258	1.35	Gm11271	predicted gene 11271	1051	0.29
chr2_94243013_94244880	1.34	Mir670hg	MIR670 host gene (non-protein coding)	608	0.62
chr11_94995250_94996098	1.34	Ppp1r9b	protein phosphatase 1, regulatory subunit 9B	390	0.75
chr5_22341654_22342038	1.33	Reln	reelin	2844	0.2
chr5_9722064_9722215	1.30	Grm3	glutamate receptor, metabotropic 3	3031	0.3
chr10_39729709_39729860	1.29	E130307A14Rik	RIKEN cDNA E130307A14 gene	1603	0.27
chr7_103825389_103825783	1.25	Hbb-bs	hemoglobin, beta adult s chain	2139	0.11
chrX_9019650_9019801	1.21	Gm9431	predicted gene 9431	9648	0.07
chr10_105689563_105689778	1.19	n-R5s80	nuclear encoded rRNA 5S 80	114527	0.05
chr13_115911109_115911441	1.18	Gm18135	predicted gene, 18135	140339	0.05
chr10_63276979_63277164	1.18	Herc4	hect domain and RLD 4	1332	0.31
chr16_8540255_8540422	1.16	Abat	4-aminobutyrate aminotransferase	26853	0.14
chr10_23674717_23675319	1.15	4930520K02Rik	RIKEN cDNA 4930520K02 gene	52870	0.11
chr5_51566574_51566861	1.15	Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	987	0.6
chr15_85676712_85677176	1.14	Lncppara	long noncoding RNA near Ppara	23328	0.12
chr19_36054870_36055220	1.12	Htr7	5-hydroxytryptamine (serotonin) receptor 7	2295	0.33
chr13_8211692_8211843	1.12	Adarb2	adenosine deaminase, RNA-specific, B2	8845	0.18
chr15_9529382_9529634	1.12	Il7r	interleukin 7 receptor	258	0.94
chr3_16817433_16817601	1.10	Gm26485	predicted gene, 26485	5795	0.35
chr4_108299089_108299240	1.09	Zyg11b	zyg-ll family member B, cell cycle regulator	1932	0.25
chr1_194622071_194623282	1.09	Plxna2	plexin A2	2851	0.26
chr4_97788585_97788930	1.09	E130114P18Rik	RIKEN cDNA E130114P18 gene	10679	0.2
chr6_86079772_86080184	1.08	Add2	adducin 2 (beta)	1894	0.25
chr3_17582970_17583121	1.07	Gm38154	predicted gene, 38154	87643	0.09
chr9_74864280_74865379	1.07	Onecut1	one cut domain, family member 1	1655	0.3
chr11_37561013_37561164	1.05	Gm12128	predicted gene 12128	97901	0.09
chr16_16558986_16560577	1.04	Fgd4	FYVE, RhoGEF and PH domain containing 4	209	0.94
chr10_95790859_95791151	1.01	4732465J04Rik	RIKEN cDNA 4732465J04 gene	12088	0.12
chr13_83714553_83714869	1.00	C130071C03Rik	RIKEN cDNA C130071C03 gene	6670	0.14
chr2_169998849_169999000	0.99	AY702102	cDNA sequence AY702102	35737	0.21
chr5_8621588_8621754	0.99	Rundc3b	RUN domain containing 3B	1281	0.47
chr9_88550647_88551163	0.98	Zfp949	zinc finger protein 949	2722	0.14
chr10_73379238_73379395	0.98	Gm19168	predicted gene, 19168	3283	0.31
chr9_41589121_41589444	0.98	Mir100hg	Mir100 Mirlet7a-2 Mir125b-1 cluster host gene	788	0.48
chr8_31939339_31939953	0.95	Nrg1	neuregulin 1	10389	0.25
chr15_88290858_88291278	0.95	B230214G05Rik	RIKEN cDNA B230214G05 gene	23806	0.21
chr3_17800898_17801130	0.91	Gm23441	predicted gene, 23441	2733	0.24
chr2_131911163_131911433	0.91	Prn	prion protein readthrough transcript	1341	0.27
chr13_71157717_71158937	0.90	Mir466f-4	microRNA 466f-4	51238	0.17
chr1_137606248_137606653	0.90	Gm37903	predicted gene, 37903	75220	0.1
chr4_46854379_46855929	0.89	Gabbr2	gamma-aminobutyric acid (GABA) B receptor, 2	4748	0.3
chr12_40447960_40448111	0.89	Dock4	dedicator of cytokinesis 4	1699	0.36
chr10_29531048_29531256	0.89	Gm48159	predicted gene, 48159	3565	0.21
chr2_169445439_169445840	0.88	Gm14249	predicted gene 14249	34978	0.16
chr16_42339015_42340584	0.88	Gap43	growth associated protein 43	852	0.7
chr4_88029546_88030118	0.88	Mllt3	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3	2981	0.22
chr8_41054476_41055299	0.87	Mtus1	mitochondrial tumor suppressor 1	93	0.95
chrX_95476704_95476855	0.86	Asb12	ankyrin repeat and SOCS box-containing 12	1350	0.47
chr15_58889728_58889985	0.86	Gm49356	predicted gene, 49356	558	0.44
chr14_99521583_99522333	0.86	Gm41230	predicted gene, 41230	587	0.8
chr6_13832798_13833136	0.85	Gpr85	G protein-coupled receptor 85	4274	0.24
chr5_133571082_133571461	0.84	Gm36667	predicted gene, 36667	27135	0.21
chrX_164439505_164439752	0.83	Asb11	ankyrin repeat and SOCS box-containing 11	1570	0.35
chr5_70841090_70841579	0.83	Gabrg1	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	870	0.75
chr4_134866605_134866756	0.83	Rhd	Rh blood group, D antigen	2144	0.27
chr1_6732598_6732857	0.83	St18	suppression of tumorigenicity 18	2143	0.43
chr13_34340668_34341142	0.82	Slc22a23	solute carrier family 22, member 23	3298	0.23
chr5_17835023_17835212	0.82	Cd36	CD36 molecule	579	0.85
chr5_52440219_52440498	0.82	Gm3519	predicted gene 3519	801	0.62
chr8_108535196_108536010	0.81	Gm39244	predicted gene, 39244	1344	0.54
chr9_42460457_42460722	0.80	Tbcel	tubulin folding cofactor E-like	872	0.57
chrX_144685908_144686546	0.79	Trpc5	transient receptor potential cation channel, subfamily C, member 5	1776	0.37
chr2_105675959_105678109	0.79	Pax6	paired box 6	905	0.54
chr1_42230776_42231106	0.79	Gm9915	predicted gene 9915	1214	0.46
chr9_91404809_91406365	0.79	Gm29478	predicted gene 29478	1113	0.42
chr13_78193022_78193812	0.78	Nr2f1	nuclear receptor subfamily 2, group F, member 1	2956	0.18
chr16_4414999_4415926	0.78	Adcy9	adenylate cyclase 9	4125	0.25
chr2_45111564_45111715	0.77	Zeb2	zinc finger E-box binding homeobox 2	465	0.57
chr5_66678971_66679451	0.77	Uchl1	ubiquitin carboxy-terminal hydrolase L1	2319	0.2
chr8_12400578_12402091	0.77	Gm25239	predicted gene, 25239	4931	0.15
chr11_46448271_46448491	0.76	Gm12168	predicted gene 12168	2966	0.17
chr1_172028424_172029004	0.76	Vangl2	VANGL planar cell polarity 2	270	0.87
chr11_29170569_29170729	0.74	Ppp4r3b	protein phosphatase 4 regulatory subunit 3B	2241	0.26
chr10_90043418_90043569	0.74	Anks1b	ankyrin repeat and sterile alpha motif domain containing 1B	3129	0.37
chr5_125056018_125058841	0.74	Gm42838	predicted gene 42838	412	0.71
chr12_29724156_29724307	0.73	C630031E19Rik	RIKEN cDNA C630031E19 gene	37786	0.21
chr7_85289417_85289568	0.73	Gm20415	predicted gene 20415	119	0.96
chr6_86636670_86636892	0.73	Asprv1	aspartic peptidase, retroviral-like 1	8617	0.11
chr15_51363475_51363626	0.73	Gm19303	predicted gene, 19303	32060	0.24
chr1_160060957_160061168	0.72	4930523C07Rik	RIKEN cDNA 4930523C07 gene	14100	0.15
chr19_10303270_10303421	0.72	Dagla	diacylglycerol lipase, alpha	1512	0.33
chr3_67892003_67892637	0.71	Iqschfp	Iqcj and Schip1 fusion protein	88	0.51
chr8_93814307_93815014	0.71	4930488L21Rik	RIKEN cDNA 4930488L21 gene	938	0.54
chr6_58905914_58906262	0.70	Nap1l5	nucleosome assembly protein 1-like 5	585	0.62
chr18_35210523_35210985	0.69	Ctnna1	catenin (cadherin associated protein), alpha 1	4176	0.2
chr7_24529166_24529317	0.69	AC161166.1	zinc finger protein 576 (ZNF576) pseudogene	601	0.47
chr13_96668711_96668944	0.69	Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	827	0.56
chr6_88803414_88803565	0.68	Gm44001	predicted gene, 44001	1246	0.32
chr11_38681045_38681331	0.67	Gm23520	predicted gene, 23520	117089	0.07
chr10_106472759_106472910	0.67	Ppfia2	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	2488	0.3
chr2_57697097_57697716	0.66	Gm25388	predicted gene, 25388	43584	0.16
chr11_35977679_35978225	0.66	Wwc1	WW, C2 and coiled-coil domain containing 1	2575	0.32
chr12_49397455_49398044	0.66	3110039M20Rik	RIKEN cDNA 3110039M20 gene	7090	0.14
chr12_108425010_108425685	0.66	Eml1	echinoderm microtubule associated protein like 1	2269	0.3
chr5_143548758_143550004	0.66	Fam220a	family with sequence similarity 220, member A	341	0.84
chr7_61220273_61220470	0.66	Gm38451	predicted gene, 38451	89687	0.08
chr10_93695291_93695671	0.65	Gm15915	predicted gene 15915	12159	0.14
chr5_57723103_57723321	0.65	Pcdh7	protocadherin 7	1003	0.34
chrX_64810691_64810842	0.64	Gm26111	predicted gene, 26111	10255	0.23
chr3_104217848_104218047	0.64	Magi3	membrane associated guanylate kinase, WW and PDZ domain containing 3	2156	0.19
chr2_37264254_37264405	0.64	Olfr367-ps	olfactory receptor 367, pseudogene	2622	0.2
chr5_90655963_90656577	0.64	Rassf6	Ras association (RalGDS/AF-6) domain family member 6	15613	0.16
chr7_132262164_132262500	0.63	Chst15	carbohydrate sulfotransferase 15	16293	0.17
chr13_83727321_83728283	0.63	C130071C03Rik	RIKEN cDNA C130071C03 gene	304	0.83
chr1_136960004_136960405	0.63	Nr5a2	nuclear receptor subfamily 5, group A, member 2	176	0.96
chr7_78578604_78579236	0.63	Gm9885	predicted gene 9885	90	0.69
chrX_135887222_135887438	0.63	Bhlhb9	basic helix-loop-helix domain containing, class B9	1347	0.42
chr9_113507383_113507910	0.63	AU023762	expressed sequence AU023762	709	0.71
chr14_77158532_77158695	0.63	Enox1	ecto-NOX disulfide-thiol exchanger 1	1833	0.41
chr4_9273042_9273193	0.62	Clvs1	clavesin 1	1662	0.42
chr7_77445511_77445911	0.62	Gm44608	predicted gene 44608	33138	0.25
chrX_60146958_60147936	0.61	Mcf2	mcf.2 transforming sequence	196	0.96
chr6_55680954_55681113	0.61	Neurod6	neurogenic differentiation 6	230	0.94
chr14_45221914_45222158	0.61	Txndc16	thioredoxin domain containing 16	1708	0.23
chr7_35837426_35837577	0.61	Gm28514	predicted gene 28514	759	0.67
chr14_100026766_100027149	0.61	Klf12	Kruppel-like factor 12	83249	0.1
chr12_8561626_8561925	0.61	5033421B08Rik	RIKEN cDNA 5033421B08 gene	12154	0.18
chr8_12388354_12388751	0.60	Gm45560	predicted gene 45560	1616	0.27
chr2_85431998_85432149	0.60	Olfr994	olfactory receptor 994	1246	0.27
chr12_107999037_107999696	0.60	Bcl11b	B cell leukemia/lymphoma 11B	4048	0.33
chr8_60952040_60952217	0.60	Clcn3	chloride channel, voltage-sensitive 3	2620	0.24
chr10_126002862_126003306	0.60	Lrig3	leucine-rich repeats and immunoglobulin-like domains 3	8547	0.26
chr13_109927479_109928182	0.59	Pde4d	phosphodiesterase 4D, cAMP specific	986	0.65
chr14_36966037_36966188	0.59	Ccser2	coiled-coil serine rich 2	2575	0.3
chr2_79451460_79451814	0.59	Neurod1	neurogenic differentiation 1	5114	0.23
chr9_16498247_16498398	0.59	Fat3	FAT atypical cadherin 3	2963	0.38
chr4_27981464_27981615	0.58	Tpm3-rs2	tropomyosin 3, related sequence 2	15366	0.27
chr12_116283592_116283802	0.58	Esyt2	extended synaptotagmin-like protein 2	2446	0.19
chr9_102720016_102720747	0.58	Amotl2	angiomotin-like 2	94	0.95
chr15_59079090_59079241	0.58	Mtss1	MTSS I-BAR domain containing 1	2824	0.32
chr7_54069871_54070022	0.58	Gm27921	predicted gene, 27921	61366	0.14
chr8_23414255_23415055	0.57	Sfrp1	secreted frizzled-related protein 1	3153	0.33
chr17_80946883_80947193	0.57	Tmem178	transmembrane protein 178	2406	0.31
chr15_85677376_85679232	0.57	Lncppara	long noncoding RNA near Ppara	24688	0.12
chrX_169829854_169830387	0.56	Mid1	midline 1	1961	0.41
chr19_19058784_19059088	0.56	Rorb	RAR-related orphan receptor beta	52260	0.17
chr6_114289017_114289311	0.56	Slc6a1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	6374	0.27
chr2_106716257_106716636	0.56	Mpped2	metallophosphoesterase domain containing 2	14044	0.23
chr6_131783861_131784012	0.56	Tas2r114	taste receptor, type 2, member 114	93873	0.05
chr4_19441647_19441884	0.55	Cpne3	copine III	101913	0.07
chr15_79684785_79686121	0.55	Josd1	Josephin domain containing 1	2466	0.13
chr10_77220323_77220656	0.55	Pofut2	protein O-fucosyltransferase 2	38729	0.12
chr2_135712427_135712633	0.54	Gm14211	predicted gene 14211	19376	0.18
chr9_4793875_4794307	0.54	Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	1428	0.59
chr13_100743804_100744148	0.54	Mrps36	mitochondrial ribosomal protein S36	137	0.93
chr19_37177777_37178526	0.54	Cpeb3	cytoplasmic polyadenylation element binding protein 3	134	0.91
chr2_120409901_120410052	0.54	Ganc	glucosidase, alpha; neutral C	1437	0.34
chr4_117131304_117132383	0.53	Plk3	polo like kinase 3	1956	0.12
chr3_4796861_4798079	0.53	1110015O18Rik	RIKEN cDNA 1110015O18 gene	88	0.98
chr7_90144986_90145137	0.53	Gm45222	predicted gene 45222	887	0.45
chr10_123266080_123266231	0.53	Tafa2	TAFA chemokine like family member 2	1170	0.53
chr12_72234504_72235243	0.53	Rtn1	reticulon 1	866	0.66
chr18_43311052_43311203	0.52	Dpysl3	dihydropyrimidinase-like 3	34431	0.17
chr3_58418728_58419191	0.52	Tsc22d2	TSC22 domain family, member 2	1475	0.4
chr16_72693661_72693848	0.52	Robo1	roundabout guidance receptor 1	30550	0.26
chr18_69354372_69354523	0.52	Tcf4	transcription factor 4	5503	0.29
chr3_145591307_145591663	0.52	Znhit6	zinc finger, HIT type 6	4383	0.23
chr9_80306711_80307237	0.52	Myo6	myosin VI	60	0.98
chr1_42709764_42710511	0.52	Pantr2	POU domain, class 3, transcription factor 3 adjacent noncoding transcript 2	2085	0.24
chr3_123688480_123688631	0.51	Gm42510	predicted gene 42510	583	0.69
chr3_88534632_88537050	0.51	Mir1905	microRNA 1905	541	0.52
chr16_38095027_38095536	0.50	Gsk3b	glycogen synthase kinase 3 beta	4993	0.25
chr6_23836472_23836623	0.50	Cadps2	Ca2+-dependent activator protein for secretion 2	2590	0.4
chr1_176811621_176811894	0.50	Cep170	centrosomal protein 170	2310	0.18
chr17_40811481_40812037	0.49	Rhag	Rhesus blood group-associated A glycoprotein	575	0.7
chr1_91543666_91543817	0.49	Asb1	ankyrin repeat and SOCS box-containing 1	2661	0.22
chr4_132883220_132883371	0.49	Stx12	syntaxin 12	1214	0.3
chr14_76432230_76432381	0.49	Tsc22d1	TSC22 domain family, member 1	5461	0.29
chr11_98323740_98324755	0.49	Neurod2	neurogenic differentiation 2	5401	0.1
chr9_41584760_41585051	0.48	Mir100hg	Mir100 Mirlet7a-2 Mir125b-1 cluster host gene	2864	0.14
chr17_47632404_47632673	0.48	Usp49	ubiquitin specific peptidase 49	1848	0.18
chr3_88211471_88212561	0.48	Gm3764	predicted gene 3764	2469	0.11
chrY_1285401_1285776	0.48	Ddx3y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked	994	0.48
chr11_85341476_85341832	0.47	Bcas3	breast carcinoma amplified sequence 3	11513	0.2
chr3_86448842_86449085	0.47	Gm25039	predicted gene, 25039	64716	0.1
chr16_38293748_38294005	0.47	Nr1i2	nuclear receptor subfamily 1, group I, member 2	948	0.48
chr1_61472065_61473256	0.47	Gm25839	predicted gene, 25839	2219	0.24
chr4_15130212_15130363	0.47	Necab1	N-terminal EF-hand calcium binding protein 1	18674	0.21
chr11_54026747_54027441	0.47	Slc22a4	solute carrier family 22 (organic cation transporter), member 4	858	0.54
chr4_108849566_108849717	0.46	Kti12	KTI12 homolog, chromatin associated	1856	0.25
chr1_169929579_169930428	0.46	Ccdc190	coiled-coil domain containing 190	74	0.97
chr3_17797523_17798047	0.46	Mir124-2hg	Mir124-2 host gene (non-protein coding)	2041	0.27
chr17_71205988_71206421	0.46	Lpin2	lipin 2	1528	0.36

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:2000474	regulation of opioid receptor signaling pathway(GO:2000474)
0.3	1.1	GO:0001915	negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.2	1.0	GO:0030035	microspike assembly(GO:0030035)
0.2	0.7	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2	0.7	GO:0009139	dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.2	0.7	GO:0060448	dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.2	0.6	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.2	0.6	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.2	0.5	GO:0070094	positive regulation of glucagon secretion(GO:0070094)
0.1	0.8	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.1	0.9	GO:0016198	axon choice point recognition(GO:0016198)
0.1	0.5	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.1	0.5	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.1	0.4	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
0.1	0.4	GO:0035928	rRNA import into mitochondrion(GO:0035928)
0.1	0.6	GO:0072488	ammonium transmembrane transport(GO:0072488)
0.1	0.4	GO:0048023	positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.1	0.4	GO:0021698	cerebellar cortex structural organization(GO:0021698)
0.1	0.3	GO:2000111	positive regulation of macrophage apoptotic process(GO:2000111)
0.1	0.4	GO:0061113	pancreas morphogenesis(GO:0061113)
0.1	0.3	GO:1902630	regulation of membrane hyperpolarization(GO:1902630)
0.1	0.1	GO:1901256	macrophage colony-stimulating factor production(GO:0036301) granulocyte colony-stimulating factor production(GO:0071611) regulation of granulocyte colony-stimulating factor production(GO:0071655) regulation of macrophage colony-stimulating factor production(GO:1901256)
0.1	0.3	GO:0097477	lateral motor column neuron migration(GO:0097477)
0.1	0.2	GO:0061535	glutamate secretion, neurotransmission(GO:0061535)
0.1	0.3	GO:0048880	sensory system development(GO:0048880)
0.1	0.3	GO:0038171	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.1	0.3	GO:0042908	xenobiotic transport(GO:0042908)
0.1	0.2	GO:0045472	response to ether(GO:0045472)
0.1	0.2	GO:1903061	positive regulation of protein lipidation(GO:1903061)
0.1	0.2	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.1	0.4	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1	0.2	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.1	0.2	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.1	2.1	GO:0034605	cellular response to heat(GO:0034605)
0.1	0.2	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1	0.2	GO:0048682	axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1	0.2	GO:1904956	regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.1	0.6	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.1	0.2	GO:0032474	otolith morphogenesis(GO:0032474)
0.1	0.4	GO:0045908	negative regulation of vasodilation(GO:0045908)
0.1	0.2	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.1	0.1	GO:0061642	chemoattraction of axon(GO:0061642)
0.1	0.1	GO:1904526	regulation of microtubule binding(GO:1904526) positive regulation of microtubule binding(GO:1904528)
0.1	0.2	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.1	0.2	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
0.1	0.7	GO:0021542	dentate gyrus development(GO:0021542)
0.1	0.3	GO:0015879	carnitine transport(GO:0015879)
0.1	0.2	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.1	0.2	GO:0007412	axon target recognition(GO:0007412)
0.1	0.2	GO:2000152	regulation of ubiquitin-specific protease activity(GO:2000152)
0.0	0.3	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.1	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.1	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0	0.3	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.1	GO:0071462	cellular response to water stimulus(GO:0071462)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.2	GO:0015886	heme transport(GO:0015886)
0.0	0.1	GO:1904339	negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0	0.1	GO:0072051	juxtaglomerular apparatus development(GO:0072051)
0.0	0.1	GO:2000686	regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0	0.4	GO:0070257	positive regulation of mucus secretion(GO:0070257)
0.0	0.1	GO:1901656	glycoside transport(GO:1901656)
0.0	0.9	GO:0035640	exploration behavior(GO:0035640)
0.0	0.2	GO:0021540	corpus callosum morphogenesis(GO:0021540)
0.0	0.3	GO:0021796	cerebral cortex regionalization(GO:0021796)
0.0	0.7	GO:0010758	regulation of macrophage chemotaxis(GO:0010758)
0.0	0.2	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	0.9	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	0.2	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.6	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.3	GO:0097120	receptor localization to synapse(GO:0097120)
0.0	0.1	GO:0090135	actin filament branching(GO:0090135)
0.0	0.3	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.2	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.1	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.0	0.2	GO:0034047	regulation of protein phosphatase type 2A activity(GO:0034047)
0.0	0.4	GO:0010763	positive regulation of fibroblast migration(GO:0010763)
0.0	0.1	GO:0021960	anterior commissure morphogenesis(GO:0021960)
0.0	0.1	GO:0035459	cargo loading into vesicle(GO:0035459)
0.0	0.2	GO:2000052	positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.1	GO:0048769	sarcomerogenesis(GO:0048769)
0.0	0.5	GO:0006103	2-oxoglutarate metabolic process(GO:0006103)
0.0	0.1	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0	0.2	GO:2001135	regulation of endocytic recycling(GO:2001135)
0.0	0.3	GO:0060628	regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0	0.2	GO:0045176	apical protein localization(GO:0045176)
0.0	0.1	GO:0071233	response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.0	0.6	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.1	GO:0055059	asymmetric neuroblast division(GO:0055059)
0.0	0.1	GO:0035087	siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.0	0.1	GO:0032229	negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.0	0.1	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0	0.0	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0	0.1	GO:2000630	positive regulation of miRNA metabolic process(GO:2000630)
0.0	0.2	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.0	0.2	GO:0002091	negative regulation of receptor internalization(GO:0002091)
0.0	0.1	GO:0015838	amino-acid betaine transport(GO:0015838)
0.0	0.1	GO:0021764	amygdala development(GO:0021764)
0.0	0.1	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.1	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406)
0.0	0.0	GO:0032484	Ral protein signal transduction(GO:0032484)
0.0	0.2	GO:0021785	branchiomotor neuron axon guidance(GO:0021785)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.2	GO:0051292	nuclear pore complex assembly(GO:0051292)
0.0	0.1	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.1	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.1	GO:0048254	snoRNA localization(GO:0048254)
0.0	0.1	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.3	GO:0060074	synapse maturation(GO:0060074)
0.0	0.3	GO:0071475	cellular hyperosmotic salinity response(GO:0071475)
0.0	0.1	GO:0032907	transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910)
0.0	0.1	GO:0035881	amacrine cell differentiation(GO:0035881)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
0.0	0.0	GO:0009642	response to light intensity(GO:0009642)
0.0	0.2	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0	0.2	GO:0035751	regulation of lysosomal lumen pH(GO:0035751)
0.0	0.1	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.0	0.1	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
0.0	0.3	GO:0016082	synaptic vesicle priming(GO:0016082)
0.0	0.1	GO:0036233	glycine import(GO:0036233)
0.0	0.1	GO:0060024	rhythmic synaptic transmission(GO:0060024)
0.0	0.1	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.0	GO:1903598	positive regulation of gap junction assembly(GO:1903598)
0.0	0.1	GO:1903334	positive regulation of protein folding(GO:1903334)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:2000809	positive regulation of synaptic vesicle clustering(GO:2000809)
0.0	0.3	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.1	GO:0071498	cellular response to fluid shear stress(GO:0071498)
0.0	0.1	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0	0.1	GO:0021891	olfactory bulb interneuron development(GO:0021891)
0.0	0.0	GO:0009298	GDP-mannose biosynthetic process(GO:0009298)
0.0	0.1	GO:0030311	poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0	0.1	GO:1903504	regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.1	GO:0035988	chondrocyte proliferation(GO:0035988)
0.0	0.1	GO:0030050	vesicle transport along actin filament(GO:0030050)
0.0	0.2	GO:0010842	retina layer formation(GO:0010842)
0.0	0.0	GO:0071376	response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0	0.2	GO:0051968	positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.0	0.1	GO:0042505	tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525)
0.0	0.1	GO:0021521	ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0	0.0	GO:0043974	histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.0	0.1	GO:2000628	regulation of miRNA metabolic process(GO:2000628)
0.0	0.1	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0	0.1	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0	0.0	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.1	GO:0050975	sensory perception of touch(GO:0050975)
0.0	0.1	GO:0031507	heterochromatin assembly(GO:0031507)
0.0	1.2	GO:0014065	phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0	0.0	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0097112	gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0	0.0	GO:0014873	response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.0	0.0	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0	0.1	GO:0097264	self proteolysis(GO:0097264)
0.0	0.0	GO:0033091	positive regulation of immature T cell proliferation(GO:0033091)
0.0	0.0	GO:1902606	regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608)
0.0	0.1	GO:0097034	mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0	0.0	GO:1903215	negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0	0.0	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.1	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
0.0	0.1	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0	0.1	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.0	0.1	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.0	0.0	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.1	GO:0071139	resolution of recombination intermediates(GO:0071139)
0.0	0.0	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0	0.3	GO:0050927	positive regulation of positive chemotaxis(GO:0050927)
0.0	0.3	GO:0051966	regulation of synaptic transmission, glutamatergic(GO:0051966)
0.0	0.2	GO:0048679	regulation of axon regeneration(GO:0048679)
0.0	0.3	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.0	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.0	0.2	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0	0.1	GO:0000160	phosphorelay signal transduction system(GO:0000160)
0.0	0.0	GO:0090166	Golgi disassembly(GO:0090166)
0.0	0.1	GO:0071918	urea transmembrane transport(GO:0071918)
0.0	0.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.9	GO:0050684	regulation of mRNA processing(GO:0050684)
0.0	0.0	GO:0070949	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0	0.0	GO:1902302	regulation of potassium ion export(GO:1902302)
0.0	0.0	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.0	0.1	GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591)
0.0	0.1	GO:0070475	rRNA base methylation(GO:0070475)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.0	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0	0.0	GO:2000507	positive regulation of energy homeostasis(GO:2000507)
0.0	0.5	GO:0045454	cell redox homeostasis(GO:0045454)
0.0	0.2	GO:0048821	erythrocyte development(GO:0048821)
0.0	0.0	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.0	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.1	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.0	0.2	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.0	0.1	GO:0006621	protein retention in ER lumen(GO:0006621)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.0	GO:0044326	dendritic spine neck(GO:0044326)
0.1	0.5	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1	0.2	GO:0097648	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.1	0.3	GO:0032983	kainate selective glutamate receptor complex(GO:0032983)
0.1	0.4	GO:0005833	hemoglobin complex(GO:0005833)
0.1	1.1	GO:0097440	apical dendrite(GO:0097440)
0.1	0.6	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.1	0.3	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)
0.0	0.3	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0044614	nuclear pore cytoplasmic filaments(GO:0044614)
0.0	0.2	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	0.7	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.0	0.6	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.1	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.7	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.0	0.3	GO:0097449	astrocyte projection(GO:0097449)
0.0	0.6	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0	0.1	GO:1990635	proximal dendrite(GO:1990635)
0.0	0.3	GO:0031462	Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0	0.4	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.0	0.6	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.3	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.1	GO:0000835	ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0	0.2	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.2	GO:0030677	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0	0.3	GO:0071565	nBAF complex(GO:0071565)
0.0	0.1	GO:0097512	cardiac myofibril(GO:0097512)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	1.1	GO:0030175	filopodium(GO:0030175)
0.0	0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.2	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.3	GO:0043196	varicosity(GO:0043196)
0.0	0.2	GO:0005869	dynactin complex(GO:0005869)
0.0	0.1	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	0.0	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.4	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.0	0.1	GO:0061617	MICOS complex(GO:0061617)
0.0	0.2	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0044327	dendritic spine head(GO:0044327)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.0	GO:0034448	EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0	0.4	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	0.1	GO:1990909	Wnt signalosome(GO:1990909)
0.0	0.0	GO:0031298	replication fork protection complex(GO:0031298)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.5	GO:0042734	presynaptic membrane(GO:0042734)
0.0	0.1	GO:0042581	specific granule(GO:0042581)
0.0	0.1	GO:1990130	Iml1 complex(GO:1990130)
0.0	0.2	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	0.2	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0097452	GAIT complex(GO:0097452)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.0	GO:0044530	supraspliceosomal complex(GO:0044530)
0.0	0.1	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.1	GO:0044232	organelle membrane contact site(GO:0044232)
0.0	0.2	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.2	GO:0071004	U2-type prespliceosome(GO:0071004)
0.0	0.1	GO:0031261	DNA replication preinitiation complex(GO:0031261)
0.0	0.1	GO:0030125	clathrin vesicle coat(GO:0030125)
0.0	0.4	GO:0016592	mediator complex(GO:0016592)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.0	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.5	GO:0005871	kinesin complex(GO:0005871)
0.0	0.7	GO:0031526	brush border membrane(GO:0031526)
0.0	0.1	GO:0070578	RISC-loading complex(GO:0070578)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0070538	oleic acid binding(GO:0070538)
0.2	0.7	GO:0009041	uridylate kinase activity(GO:0009041)
0.2	1.1	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.2	0.6	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.1	0.3	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.1	0.4	GO:0001069	regulatory region RNA binding(GO:0001069)
0.1	0.5	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	0.4	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.1	0.4	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.1	0.1	GO:0051378	serotonin binding(GO:0051378)
0.1	0.3	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.1	0.7	GO:0003680	AT DNA binding(GO:0003680)
0.1	0.3	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.1	0.3	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.1	0.3	GO:0031721	hemoglobin alpha binding(GO:0031721)
0.1	0.3	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1	0.3	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1	0.2	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.1	0.2	GO:0015232	heme transporter activity(GO:0015232)
0.1	0.5	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1	0.4	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1	0.6	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.2	GO:0019808	polyamine binding(GO:0019808)
0.0	0.2	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	0.2	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.6	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.2	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.3	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.2	GO:0032184	SUMO polymer binding(GO:0032184)
0.0	0.2	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.4	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0031720	haptoglobin binding(GO:0031720)
0.0	0.1	GO:0045340	mercury ion binding(GO:0045340)
0.0	0.0	GO:0046870	cadmium ion binding(GO:0046870)
0.0	0.7	GO:0070412	R-SMAD binding(GO:0070412)
0.0	0.4	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0	0.6	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.2	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.2	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.0	0.2	GO:0043495	protein anchor(GO:0043495)
0.0	0.3	GO:0070679	inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0	0.1	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.0	0.1	GO:0043199	sulfate binding(GO:0043199)
0.0	0.6	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.0	0.5	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.1	GO:0004667	prostaglandin-D synthase activity(GO:0004667)
0.0	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.4	GO:0070402	NADPH binding(GO:0070402)
0.0	0.4	GO:0099589	G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.0	0.1	GO:0071532	ankyrin repeat binding(GO:0071532)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0	0.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.5	GO:0071837	HMG box domain binding(GO:0071837)
0.0	0.1	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0	0.1	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.1	GO:0051430	corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0	0.6	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0	0.3	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.0	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.3	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.2	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.0	0.2	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.1	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.2	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	0.1	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.0	0.0	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.1	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.1	GO:0000213	tRNA-intron endonuclease activity(GO:0000213)
0.0	0.1	GO:0051022	Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0	0.1	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:2001069	glycogen binding(GO:2001069)
0.0	0.2	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.2	GO:0004000	adenosine deaminase activity(GO:0004000)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.2	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	2.9	GO:0005516	calmodulin binding(GO:0005516)
0.0	0.7	GO:0098531	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0	0.1	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.2	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.1	GO:0070728	leucine binding(GO:0070728)
0.0	0.1	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.3	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.2	GO:0030275	LRR domain binding(GO:0030275)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.0	GO:0015440	peptide-transporting ATPase activity(GO:0015440)
0.0	0.1	GO:0015265	urea channel activity(GO:0015265)
0.0	0.3	GO:0031489	myosin V binding(GO:0031489)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.0	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0	0.0	GO:0016649	electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0	1.1	GO:0004896	cytokine receptor activity(GO:0004896)
0.0	0.2	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.0	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.0	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.5	GO:0005109	frizzled binding(GO:0005109)
0.0	1.0	GO:0004702	receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0	0.0	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.0	GO:1901612	cardiolipin binding(GO:1901612)
0.0	0.4	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)
0.0	0.3	GO:0043738	N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.0	0.0	GO:0000253	3-keto sterol reductase activity(GO:0000253)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.0	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.9	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
1.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	PID BARD1 PATHWAY	BARD1 signaling events
0.5	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.8	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.3	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.5	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.5	PID REELIN PATHWAY	Reelin signaling pathway
0.2	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.2	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.1	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.5	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	0.8	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1	0.1	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.0	1.3	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.4	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.5	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	0.5	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0	0.4	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.3	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.2	REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	Genes involved in p53-Dependent G1 DNA Damage Response
0.0	1.3	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.7	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.6	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.5	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.6	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	0.2	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.2	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.4	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.0	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	1.0	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	0.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	0.5	REACTOME NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Neurotransmitter Release Cycle
0.0	0.0	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.0	REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	Genes involved in Activation of NMDA receptor upon glutamate binding and postsynaptic events
0.0	0.1	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.0	REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	Genes involved in Transmission across Chemical Synapses
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.4	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression