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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Spdef

Z-value: 0.48

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Transcription factors associated with Spdef

Gene Symbol	Gene ID	Gene Info
Spdef Ensembl NCBI MGI UniProt	ENSMUSG00000024215.7	Spdef

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Spdef	chr17_27726230_27726673	2438	0.186996	0.41	1.3e-03	Click!
Spdef	chr17_27725174_27725943	3331	0.155451	0.32	1.2e-02	Click!
Spdef	chr17_27726810_27726998	1985	0.218732	0.28	3.3e-02	Click!
Spdef	chr17_27728247_27728914	309	0.836350	0.19	1.4e-01	Click!
Spdef	chr17_27727948_27728145	843	0.482827	0.12	3.5e-01	Click!

Activity of the Spdef motif across conditions

Conditions sorted by the z-value of the Spdef motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_122459815_122460898	0.49	Zic5	zinc finger protein of the cerebellum 5	335	0.81
chr19_12488341_12489388	0.46	Dtx4	deltex 4, E3 ubiquitin ligase	12590	0.1
chr7_16404362_16406481	0.46	Gm45508	predicted gene 45508	1159	0.29
chr9_108824114_108825614	0.45	Gm35025	predicted gene, 35025	3	0.87
chr8_45509543_45510137	0.44	Sorbs2	sorbin and SH3 domain containing 2	1922	0.33
chr3_31097203_31098928	0.43	Skil	SKI-like	1232	0.48
chr7_16982884_16983633	0.42	Gm42372	predicted gene, 42372	172	0.9
chr14_122477737_122477888	0.41	Zic2	zinc finger protein of the cerebellum 2	288	0.83
chrX_153501207_153502250	0.37	Ubqln2	ubiquilin 2	3501	0.22
chrX_170676003_170677019	0.36	Asmt	acetylserotonin O-methyltransferase	3867	0.35
chrX_105390628_105392456	0.34	5330434G04Rik	RIKEN cDNA 5330434G04 gene	212	0.93
chr2_6883618_6884699	0.32	Gm13389	predicted gene 13389	112	0.85
chr4_156183474_156184054	0.32	Agrn	agrin	2137	0.17
chr10_92160735_92161461	0.31	Rmst	rhabdomyosarcoma 2 associated transcript (non-coding RNA)	1663	0.4
chr5_120433178_120434996	0.30	Gm27199	predicted gene 27199	2320	0.19
chr13_34127276_34127957	0.30	Tubb2b	tubulin, beta 2B class IIB	2738	0.15
chr13_83715222_83716973	0.30	C130071C03Rik	RIKEN cDNA C130071C03 gene	5284	0.15
chr11_80479429_80480178	0.29	Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	2747	0.26
chr1_6733530_6734383	0.29	St18	suppression of tumorigenicity 18	914	0.7
chr11_96334278_96335532	0.28	Hoxb3	homeobox B3	6040	0.08
chr4_110284419_110284817	0.28	Elavl4	ELAV like RNA binding protein 4	1998	0.47
chr7_126041945_126042146	0.28	Gm44874	predicted gene 44874	22402	0.17
chr8_89036575_89038609	0.27	Sall1	spalt like transcription factor 1	6570	0.23
chr9_79829898_79830916	0.27	Filip1	filamin A interacting protein 1	591	0.7
chr5_110543976_110545228	0.27	Galnt9	polypeptide N-acetylgalactosaminyltransferase 9	247	0.9
chr4_6445169_6445688	0.27	Nsmaf	neutral sphingomyelinase (N-SMase) activation associated factor	899	0.62
chr10_130279504_130280322	0.26	Neurod4	neurogenic differentiation 4	327	0.87
chr5_73189782_73190392	0.26	Gm42571	predicted gene 42571	330	0.81
chr9_44340460_44342952	0.26	Hmbs	hydroxymethylbilane synthase	473	0.51
chr12_110187430_110189676	0.25	Gm34785	predicted gene, 34785	492	0.73
chr10_79869256_79869624	0.25	Plppr3	phospholipid phosphatase related 3	2159	0.09
chr1_77503797_77505059	0.25	Mir6352	microRNA 6352	7660	0.19
chr13_83740463_83741042	0.25	C130071C03Rik	RIKEN cDNA C130071C03 gene	1889	0.2
chr2_151968839_151969749	0.24	Mir1953	microRNA 1953	1677	0.26
chr5_139543263_139545139	0.24	Uncx	UNC homeobox	303	0.89
chr13_99780787_99781532	0.24	Gm24471	predicted gene, 24471	88630	0.08
chr11_69554884_69555035	0.23	Efnb3	ephrin B3	5246	0.09
chr2_24473566_24475385	0.23	Pax8	paired box 8	622	0.64
chr14_122475443_122476757	0.23	Zic2	zinc finger protein of the cerebellum 2	665	0.44
chr2_74725879_74728683	0.23	Hoxd4	homeobox D4	207	0.67
chr7_70108517_70108933	0.23	Gm35325	predicted gene, 35325	98710	0.07
chr9_108829719_108830312	0.23	Celsr3	cadherin, EGF LAG seven-pass G-type receptor 3	1725	0.18
chr7_133700065_133700317	0.23	Uros	uroporphyrinogen III synthase	2111	0.2
chr4_124660613_124661391	0.23	Gm2164	predicted gene 2164	3833	0.13
chr13_112695809_112696082	0.23	Gm18883	predicted gene, 18883	3734	0.17
chr5_139546076_139547826	0.23	Uncx	UNC homeobox	3053	0.23
chr11_96331807_96334248	0.22	Hoxb3	homeobox B3	4965	0.08
chr2_18044333_18044941	0.22	Skida1	SKI/DACH domain containing 1	65	0.95
chr2_157026864_157027931	0.22	Soga1	suppressor of glucose, autophagy associated 1	75	0.96
chr19_53897189_53897340	0.22	Pdcd4	programmed cell death 4	3434	0.19
chr7_126979881_126980032	0.22	Cdipt	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	1723	0.13
chr6_134886811_134888239	0.22	Gpr19	G protein-coupled receptor 19	243	0.87
chr19_45193534_45193685	0.22	Tlx1os	T cell leukemia, homeobox 1, opposite strand	34305	0.12
chr7_73378126_73378277	0.22	A730056A06Rik	RIKEN cDNA A730056A06 gene	2427	0.2
chr1_177446374_177448525	0.22	Zbtb18	zinc finger and BTB domain containing 18	1628	0.31
chr14_77159311_77160431	0.22	Enox1	ecto-NOX disulfide-thiol exchanger 1	3091	0.31
chr3_55782570_55784448	0.22	Nbea	neurobeachin	19	0.96
chr1_132387629_132389330	0.22	Tmcc2	transmembrane and coiled-coil domains 2	1839	0.25
chr2_151966993_151968089	0.22	Mir1953	microRNA 1953	76	0.96
chr14_64588312_64589438	0.22	Mir124a-1hg	Mir124-1 host gene (non-protein coding)	341	0.81
chr10_109832096_109833441	0.22	Nav3	neuron navigator 3	453	0.9
chr9_65555338_65555833	0.22	Plekho2	pleckstrin homology domain containing, family O member 2	6579	0.14
chr6_90781027_90782541	0.21	Iqsec1	IQ motif and Sec7 domain 1	188	0.94
chr14_69269425_69270999	0.21	Gm27222	predicted gene 27222	11066	0.09
chr6_28828230_28829085	0.21	Lrrc4	leucine rich repeat containing 4	1688	0.37
chr2_146549745_146549896	0.21	4933406D12Rik	RIKEN cDNA 4933406D12 gene	6889	0.27
chr1_115684558_115685809	0.21	Cntnap5a	contactin associated protein-like 5A	427	0.58
chr4_154960570_154962200	0.21	Gm20421	predicted gene 20421	293	0.57
chr8_122297355_122297506	0.21	Zfpm1	zinc finger protein, multitype 1	9890	0.15
chr17_25930017_25930168	0.21	Pigq	phosphatidylinositol glycan anchor biosynthesis, class Q	916	0.29
chr10_41070697_41071486	0.21	Gpr6	G protein-coupled receptor 6	1194	0.41
chr1_66389272_66389745	0.21	Map2	microtubule-associated protein 2	2497	0.31
chr13_37845693_37845844	0.21	Rreb1	ras responsive element binding protein 1	12166	0.19
chr4_9269280_9270516	0.21	Clvs1	clavesin 1	551	0.81
chr7_49915184_49916836	0.21	Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	4310	0.29
chr12_117157079_117158175	0.21	Gm10421	predicted gene 10421	5976	0.31
chr15_59040592_59041370	0.21	Mtss1	MTSS I-BAR domain containing 1	384	0.88
chr9_114404489_114404640	0.20	Glb1	galactosidase, beta 1	3456	0.17
chr8_12399326_12400483	0.20	Gm25239	predicted gene, 25239	3501	0.16
chr14_67320401_67320669	0.20	Gm6878	predicted gene 6878	5824	0.18
chr9_91363064_91363717	0.20	Zic1	zinc finger protein of the cerebellum 1	336	0.72
chr6_52160071_52161455	0.20	Hotairm1	Hoxa transcript antisense RNA, myeloid-specific 1	2239	0.09
chr1_42691569_42692627	0.20	Pantr1	POU domain, class 3, transcription factor 3 adjacent noncoding transcript 1	995	0.42
chr3_152100022_152100538	0.20	Gipc2	GIPC PDZ domain containing family, member 2	2574	0.21
chr2_165882235_165884653	0.20	Zmynd8	zinc finger, MYND-type containing 8	766	0.54
chr15_82334694_82334845	0.20	Naga	N-acetyl galactosaminidase, alpha	1196	0.22
chr13_59669031_59669197	0.20	Golm1	golgi membrane protein 1	6658	0.1
chr13_58812962_58813113	0.20	C630044B11Rik	RIKEN cDNA C630044B11 gene	884	0.48
chr2_84386593_84388183	0.20	Calcrl	calcitonin receptor-like	12030	0.2
chr11_101084072_101084686	0.20	Coasy	Coenzyme A synthase	484	0.59
chr16_94092357_94092508	0.20	Sim2	single-minded family bHLH transcription factor 2	7501	0.15
chr8_26844152_26844303	0.20	2310008N11Rik	RIKEN cDNA 2310008N11 gene	2228	0.31
chr11_77947804_77948671	0.19	Sez6	seizure related gene 6	3068	0.17
chr9_73115681_73115832	0.19	Rsl24d1	ribosomal L24 domain containing 1	1160	0.32
chr11_84526864_84527823	0.19	Lhx1os	LIM homeobox 1, opposite strand	1659	0.31
chr14_69493829_69494689	0.19	Gm37094	predicted gene, 37094	6131	0.11
chr6_88803678_88803829	0.19	Gm44001	predicted gene, 44001	1510	0.26
chr4_21685165_21686049	0.19	Prdm13	PR domain containing 13	174	0.95
chr11_78496560_78498132	0.19	Sarm1	sterile alpha and HEAT/Armadillo motif containing 1	112	0.9
chr13_21913780_21914888	0.19	Gm44456	predicted gene, 44456	10682	0.06
chr14_69275580_69276440	0.19	Gm20236	predicted gene, 20236	6130	0.1
chr15_75620417_75621249	0.19	Zfp41	zinc finger protein 41	878	0.44
chr17_32808045_32808304	0.19	Zfp811	zinc finger protein 811	1668	0.15
chr5_5507730_5508026	0.19	Cldn12	claudin 12	6571	0.17
chr2_51144318_51145477	0.19	Rnd3	Rho family GTPase 3	4197	0.29
chrX_13244980_13245286	0.19	2010308F09Rik	RIKEN cDNA 2010308F09 gene	2603	0.17
chr11_77486623_77487566	0.19	Ankrd13b	ankyrin repeat domain 13b	2572	0.17
chr14_118234662_118235031	0.19	Gm4675	predicted gene 4675	1386	0.29
chr4_117148050_117148208	0.18	Gm13015	predicted gene 13015	794	0.3
chr11_117281297_117281448	0.18	Septin9	septin 9	15126	0.17
chr5_120431744_120433119	0.18	Gm27199	predicted gene 27199	664	0.41
chr6_55453986_55454137	0.18	Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	1884	0.37
chr15_75619003_75619950	0.18	Zfp41	zinc finger protein 41	2235	0.18
chr16_23889696_23891150	0.18	Sst	somatostatin	535	0.77
chr16_97292625_97293406	0.18	Bace2	beta-site APP-cleaving enzyme 2	63727	0.12
chr2_68365331_68365864	0.18	Stk39	serine/threonine kinase 39	922	0.69
chr15_25624832_25625841	0.18	Myo10	myosin X	2787	0.25
chr12_111690836_111691593	0.18	Gm36635	predicted gene, 36635	11868	0.09
chr5_138278285_138278436	0.18	Gpc2	glypican 2 (cerebroglycan)	123	0.87
chr1_174175177_174176129	0.18	Spta1	spectrin alpha, erythrocytic 1	2877	0.14
chr7_27735092_27735839	0.18	Zfp60	zinc finger protein 60	902	0.47
chr7_103812275_103812465	0.18	Hbb-bt	hemoglobin, beta adult t chain	1626	0.15
chr7_49911362_49912424	0.17	Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	193	0.96
chr14_54567850_54568001	0.17	Ajuba	ajuba LIM protein	4157	0.1
chr10_81114097_81114248	0.17	Map2k2	mitogen-activated protein kinase kinase 2	4440	0.08
chr13_62885645_62885887	0.17	Fbp1	fructose bisphosphatase 1	2361	0.22
chr10_19356598_19357962	0.17	Olig3	oligodendrocyte transcription factor 3	747	0.72
chr7_119184137_119185474	0.17	Gpr139	G protein-coupled receptor 139	202	0.96
chr7_121313033_121313561	0.17	4930486N12Rik	RIKEN cDNA 4930486N12 gene	53902	0.1
chr5_98182267_98183697	0.17	Prdm8	PR domain containing 8	2004	0.26
chr2_26207113_26207799	0.17	Gm27196	predicted gene 27196	754	0.37
chr1_97540278_97540732	0.17	Gm37171	predicted gene, 37171	4943	0.29
chr4_89691755_89691965	0.17	Dmrta1	doublesex and mab-3 related transcription factor like family A1	3662	0.36
chr9_122595045_122595971	0.17	9530059O14Rik	RIKEN cDNA 9530059O14 gene	23006	0.13
chr7_90886512_90887836	0.17	Gm45159	predicted gene 45159	102	0.88
chr19_15339963_15340957	0.17	Gm24319	predicted gene, 24319	339544	0.01
chrX_8072408_8072977	0.17	Suv39h1	suppressor of variegation 3-9 1	1566	0.17
chr9_65144272_65144925	0.17	Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	3386	0.18
chr9_21557298_21557458	0.17	Carm1	coactivator-associated arginine methyltransferase 1	10220	0.1
chr8_122613231_122613382	0.17	Trappc2l	trafficking protein particle complex 2-like	1660	0.17
chr8_71680412_71681032	0.17	Jak3	Janus kinase 3	2387	0.13
chr7_30331456_30331694	0.16	Gm50483	predicted gene, 50483	3223	0.09
chr2_65563921_65564380	0.16	Scn3a	sodium channel, voltage-gated, type III, alpha	3342	0.29
chr15_100402856_100403333	0.16	Slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	149	0.92
chr16_18213980_18215144	0.16	4933432I09Rik	RIKEN cDNA 4933432I09 gene	699	0.36
chr11_120825651_120826165	0.16	Fasn	fatty acid synthase	1361	0.25
chr5_115945354_115946075	0.16	Cit	citron	417	0.82
chr8_121300864_121302289	0.16	Gm26815	predicted gene, 26815	55260	0.11
chr4_129261016_129261208	0.16	C77080	expressed sequence C77080	292	0.75
chr8_104734057_104734499	0.16	Ces2a	carboxylesterase 2A	250	0.83
chr8_105689654_105689805	0.16	Carmil2	capping protein regulator and myosin 1 linker 2	1177	0.25
chr10_81212943_81213094	0.16	Atcay	ataxia, cerebellar, Cayman type	258	0.77
chr5_115362856_115363022	0.16	4930401G09Rik	RIKEN cDNA 4930401G09 gene	2816	0.11
chr15_80674911_80675205	0.16	Fam83f	family with sequence similarity 83, member F	3211	0.17
chr12_29534253_29535510	0.16	Gm20208	predicted gene, 20208	10	0.8
chr12_100998075_100998234	0.16	Gm36756	predicted gene, 36756	5182	0.14
chr7_36704669_36704859	0.16	Gm37452	predicted gene, 37452	5410	0.14
chr11_55600811_55601094	0.16	Glra1	glycine receptor, alpha 1 subunit	6781	0.21
chr13_54838015_54838197	0.16	Gm16250	predicted gene 16250	2798	0.2
chr10_99267189_99269284	0.16	Gm48089	predicted gene, 48089	340	0.78
chr8_123100430_123100798	0.16	Rpl13	ribosomal protein L13	1736	0.17
chr4_119076605_119076792	0.16	Gm12866	predicted gene 12866	7587	0.12
chr10_84457678_84458129	0.16	Gm47962	predicted gene, 47962	17077	0.12
chr13_9114890_9115041	0.16	Larp4b	La ribonucleoprotein domain family, member 4B	20983	0.14
chr11_114793014_114793463	0.16	Btbd17	BTB (POZ) domain containing 17	2635	0.19
chr14_28508967_28511864	0.16	Wnt5a	wingless-type MMTV integration site family, member 5A	203	0.89
chrX_136822812_136823259	0.16	Plp1	proteolipid protein (myelin) 1	245	0.88
chr1_193175099_193175314	0.16	A130010J15Rik	RIKEN cDNA A130010J15 gene	1462	0.25
chr3_108410436_108412210	0.16	Celsr2	cadherin, EGF LAG seven-pass G-type receptor 2	4229	0.11
chr11_54598816_54599372	0.16	Rapgef6	Rap guanine nucleotide exchange factor (GEF) 6	2920	0.29
chr19_53059154_53059713	0.16	1700054A03Rik	RIKEN cDNA 1700054A03 gene	16785	0.15
chrX_53233797_53233998	0.16	Plac1	placental specific protein 1	6214	0.18
chr7_80398560_80398838	0.15	Furin	furin (paired basic amino acid cleaving enzyme)	770	0.47
chr16_20713164_20713474	0.15	Clcn2	chloride channel, voltage-sensitive 2	349	0.71
chr2_65929929_65930575	0.15	Csrnp3	cysteine-serine-rich nuclear protein 3	115	0.97
chr8_65966341_65967718	0.15	Marchf1	membrane associated ring-CH-type finger 1	128	0.97
chr18_68398281_68398432	0.15	Mc2r	melanocortin 2 receptor	30964	0.15
chr17_32334810_32334961	0.15	Akap8l	A kinase (PRKA) anchor protein 8-like	405	0.76
chr12_11880981_11881577	0.15	Tubb2a-ps2	tubulin, beta 2a, pseudogene 2	1384	0.49
chr15_98977285_98979178	0.15	4930578M01Rik	RIKEN cDNA 4930578M01 gene	5117	0.09
chr9_55043837_55044704	0.15	Chrnb4	cholinergic receptor, nicotinic, beta polypeptide 4	4509	0.13
chr4_155886040_155886274	0.15	Ints11	integrator complex subunit 11	1622	0.16
chr5_115953777_115953928	0.15	Cit	citron	2762	0.23
chr16_91685571_91685880	0.15	Donson	downstream neighbor of SON	1290	0.29
chr2_167777077_167778323	0.15	Gm14321	predicted gene 14321	164	0.94
chr7_99368824_99368975	0.15	Gdpd5	glycerophosphodiester phosphodiesterase domain containing 5	12515	0.14
chr10_128504713_128504957	0.15	Myl6b	myosin, light polypeptide 6B	6150	0.07
chr3_17799177_17799545	0.15	Mir124-2hg	Mir124-2 host gene (non-protein coding)	3617	0.21
chr5_136989551_136989702	0.15	Plod3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	680	0.41
chr10_130276309_130276802	0.15	Neurod4	neurogenic differentiation 4	3685	0.2
chr11_69399334_69402458	0.15	Kdm6bos	KDM1 lysine (K)-specific demethylase 6B, opposite strand	617	0.47
chr8_110924044_110924195	0.15	Gm26132	predicted gene, 26132	1003	0.38
chr8_23043503_23044627	0.15	Ank1	ankyrin 1, erythroid	8834	0.18
chr4_46255563_46255724	0.15	Gm12444	predicted gene 12444	11753	0.15
chr1_132317853_132318004	0.15	Nuak2	NUAK family, SNF1-like kinase, 2	1763	0.24
chr11_118906363_118906514	0.15	Rbfox3	RNA binding protein, fox-1 homolog (C. elegans) 3	1567	0.39
chr13_99594358_99594644	0.15	Gm47158	predicted gene, 47158	33059	0.15
chr1_75277211_75278430	0.15	Resp18	regulated endocrine-specific protein 18	464	0.62
chr12_29537800_29538885	0.15	Myt1l	myelin transcription factor 1-like	3120	0.28
chr10_6788358_6789268	0.15	Oprm1	opioid receptor, mu 1	4	0.99

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Spdef

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.1	0.2	GO:0072309	mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis(GO:0072309)
0.1	0.1	GO:2000019	negative regulation of male gonad development(GO:2000019)
0.1	0.2	GO:0003213	cardiac right atrium morphogenesis(GO:0003213)
0.1	0.2	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.2	GO:0097476	motor neuron migration(GO:0097475) spinal cord motor neuron migration(GO:0097476)
0.1	0.2	GO:0032097	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.4	GO:0097119	postsynaptic density protein 95 clustering(GO:0097119)
0.0	0.1	GO:2000211	regulation of glutamate metabolic process(GO:2000211)
0.0	0.2	GO:0008582	regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.0	0.2	GO:0036233	glycine import(GO:0036233)
0.0	0.1	GO:0061205	paramesonephric duct development(GO:0061205)
0.0	0.1	GO:2000686	regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0	0.1	GO:0051081	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.1	GO:0000087	mitotic M phase(GO:0000087)
0.0	0.1	GO:2000974	negative regulation of pro-B cell differentiation(GO:2000974)
0.0	0.3	GO:0035881	amacrine cell differentiation(GO:0035881)
0.0	0.2	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:0050968	detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.0	0.1	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.0	0.1	GO:1904179	positive regulation of adipose tissue development(GO:1904179)
0.0	0.1	GO:0001555	oocyte growth(GO:0001555)
0.0	0.6	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	0.2	GO:0060689	cell differentiation involved in salivary gland development(GO:0060689)
0.0	0.0	GO:0072235	distal convoluted tubule development(GO:0072025) DCT cell differentiation(GO:0072069) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) metanephric DCT cell differentiation(GO:0072240)
0.0	0.1	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0	0.1	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.1	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.1	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.1	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.1	GO:0021586	pons maturation(GO:0021586)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:1901874	regulation of post-translational protein modification(GO:1901873) negative regulation of post-translational protein modification(GO:1901874)
0.0	0.1	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.1	GO:0034729	histone H3-K79 methylation(GO:0034729)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.1	GO:0003419	growth plate cartilage chondrocyte proliferation(GO:0003419)
0.0	0.2	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0	0.1	GO:0009629	response to gravity(GO:0009629)
0.0	0.2	GO:0048194	Golgi vesicle budding(GO:0048194)
0.0	0.1	GO:0002877	regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
0.0	0.1	GO:0070947	neutrophil mediated killing of fungus(GO:0070947)
0.0	0.1	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.0	0.1	GO:1900109	regulation of histone H3-K9 dimethylation(GO:1900109)
0.0	0.1	GO:0019747	regulation of isoprenoid metabolic process(GO:0019747)
0.0	0.0	GO:0021563	glossopharyngeal nerve development(GO:0021563)
0.0	0.1	GO:0048677	axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.0	0.1	GO:0036166	phenotypic switching(GO:0036166)
0.0	0.0	GO:0048880	sensory system development(GO:0048880)
0.0	0.0	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.2	GO:0045721	negative regulation of gluconeogenesis(GO:0045721)
0.0	0.1	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0	0.1	GO:0034653	diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.1	GO:0034969	histone arginine methylation(GO:0034969)
0.0	0.1	GO:0006569	tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.0	0.2	GO:0002087	regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0	0.1	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.1	GO:1904382	protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0	0.1	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.0	0.1	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.1	GO:1902416	positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0	0.1	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	0.1	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0	0.1	GO:0044791	modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0	0.1	GO:0006285	base-excision repair, AP site formation(GO:0006285)
0.0	0.1	GO:2000675	negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.1	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.1	GO:0048239	negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0046684	response to pyrethroid(GO:0046684)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:0019448	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.0	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.1	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.0	GO:0060084	synaptic transmission involved in micturition(GO:0060084)
0.0	0.1	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0	0.0	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.1	GO:0036015	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.0	0.1	GO:0035262	gonad morphogenesis(GO:0035262)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.1	GO:0036515	serotonergic neuron axon guidance(GO:0036515)
0.0	0.1	GO:0050915	sensory perception of sour taste(GO:0050915)
0.0	0.0	GO:0043435	response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0	0.0	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.0	0.0	GO:0033693	neurofilament bundle assembly(GO:0033693)
0.0	0.0	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.0	0.0	GO:0071205	protein localization to juxtaparanode region of axon(GO:0071205)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0045217	cell-cell junction maintenance(GO:0045217)
0.0	0.1	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0	0.1	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0001887	selenium compound metabolic process(GO:0001887)
0.0	0.1	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.0	GO:0046340	diacylglycerol catabolic process(GO:0046340)
0.0	0.0	GO:0010958	regulation of amino acid import(GO:0010958) regulation of L-arginine import(GO:0010963)
0.0	0.0	GO:0002840	T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840)
0.0	0.1	GO:0018065	protein-cofactor linkage(GO:0018065)
0.0	0.1	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0	0.1	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.0	GO:0097155	fasciculation of sensory neuron axon(GO:0097155)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.0	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045869)
0.0	0.1	GO:0000022	mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.0	0.0	GO:0043974	histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.0	0.1	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.1	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.1	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.1	GO:0010587	miRNA catabolic process(GO:0010587)
0.0	0.2	GO:0016486	peptide hormone processing(GO:0016486)
0.0	0.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.1	GO:0036265	RNA (guanine-N7)-methylation(GO:0036265)
0.0	0.0	GO:0002930	trabecular meshwork development(GO:0002930)
0.0	0.1	GO:0048631	regulation of skeletal muscle tissue growth(GO:0048631)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0016139	glycoside catabolic process(GO:0016139)
0.0	0.0	GO:0043134	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.0	0.0	GO:0061511	centriole elongation(GO:0061511)
0.0	0.2	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.0	GO:1904263	positive regulation of TORC1 signaling(GO:1904263)
0.0	0.0	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
0.0	0.1	GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0	0.3	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.1	GO:0031468	nuclear envelope reassembly(GO:0031468)
0.0	0.1	GO:0060087	relaxation of vascular smooth muscle(GO:0060087)
0.0	0.1	GO:0032202	telomere assembly(GO:0032202)
0.0	0.1	GO:0033563	dorsal/ventral axon guidance(GO:0033563)
0.0	0.0	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
0.0	0.0	GO:1902659	regulation of glucose mediated signaling pathway(GO:1902659) positive regulation of glucose mediated signaling pathway(GO:1902661)
0.0	0.1	GO:0035279	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0	0.0	GO:0002554	serotonin secretion by platelet(GO:0002554)
0.0	0.1	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0	0.1	GO:0006116	NADH oxidation(GO:0006116)
0.0	0.0	GO:0042938	dipeptide transport(GO:0042938)
0.0	0.0	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.0	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.0	0.1	GO:0009071	serine family amino acid catabolic process(GO:0009071)
0.0	0.0	GO:1903334	positive regulation of protein folding(GO:1903334)
0.0	0.1	GO:0048505	regulation of timing of cell differentiation(GO:0048505)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0048681	negative regulation of axon regeneration(GO:0048681)
0.0	0.1	GO:0031507	heterochromatin assembly(GO:0031507)
0.0	0.0	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.0	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
0.0	0.0	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.0	GO:1903298	regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.0	0.0	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.2	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0	0.0	GO:0090135	actin filament branching(GO:0090135)
0.0	0.0	GO:1902075	cellular response to salt(GO:1902075)
0.0	0.2	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	0.0	GO:0008216	spermidine metabolic process(GO:0008216)
0.0	0.0	GO:0072092	ureteric bud invasion(GO:0072092)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.0	GO:1903215	negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0	0.1	GO:0022010	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0	0.0	GO:0042402	cellular biogenic amine catabolic process(GO:0042402)
0.0	0.0	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.0	GO:0019388	galactose catabolic process(GO:0019388)
0.0	0.1	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.1	GO:1900262	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0	0.0	GO:0019230	proprioception(GO:0019230)
0.0	0.0	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.1	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.0	GO:0043622	cortical microtubule organization(GO:0043622)
0.0	0.1	GO:1900364	negative regulation of mRNA polyadenylation(GO:1900364)
0.0	0.0	GO:0097500	receptor localization to nonmotile primary cilium(GO:0097500)
0.0	0.0	GO:0046984	regulation of hemoglobin biosynthetic process(GO:0046984)
0.0	0.1	GO:0060179	male mating behavior(GO:0060179)
0.0	0.0	GO:0009310	amine catabolic process(GO:0009310)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.0	0.1	GO:0042977	activation of JAK2 kinase activity(GO:0042977)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.0	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.0	0.3	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.0	0.1	GO:0045955	negative regulation of calcium ion-dependent exocytosis(GO:0045955)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0097427	microtubule bundle(GO:0097427)
0.0	0.3	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.2	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:0038037	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.1	GO:0002142	stereocilia ankle link complex(GO:0002142)
0.0	0.1	GO:0072534	perineuronal net(GO:0072534)
0.0	0.1	GO:0044613	nuclear pore central transport channel(GO:0044613)
0.0	0.1	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.2	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	0.1	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0097454	Schwann cell microvillus(GO:0097454)
0.0	0.0	GO:1990696	USH2 complex(GO:1990696)
0.0	0.0	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0	0.0	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	0.1	GO:0036128	CatSper complex(GO:0036128)
0.0	0.1	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	0.1	GO:0097433	dense body(GO:0097433)
0.0	0.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.0	0.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.2	GO:0032433	filopodium tip(GO:0032433)
0.0	0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.0	GO:0031417	NatC complex(GO:0031417)
0.0	0.1	GO:0000783	telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0	0.0	GO:0055087	Ski complex(GO:0055087)
0.0	0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.0	GO:1990075	periciliary membrane compartment(GO:1990075)
0.0	0.2	GO:0010369	chromocenter(GO:0010369)
0.0	0.1	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.2	GO:0030904	retromer complex(GO:0030904)
0.0	0.0	GO:0090498	extrinsic component of Golgi membrane(GO:0090498)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.1	0.2	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.0	0.1	GO:0015087	cobalt ion transmembrane transporter activity(GO:0015087)
0.0	0.2	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.0	0.1	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.0	0.1	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.0	0.2	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.1	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.2	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.1	GO:0061513	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.1	GO:0017151	DEAD/H-box RNA helicase binding(GO:0017151)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.1	GO:1990932	5.8S rRNA binding(GO:1990932)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:1990715	mRNA CDS binding(GO:1990715)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.1	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.2	GO:0043176	amine binding(GO:0043176)
0.0	0.0	GO:0035851	Krueppel-associated box domain binding(GO:0035851)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0010853	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0	0.1	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.2	GO:0016215	acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.0	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0	0.1	GO:0052723	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0	0.0	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.0	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.0	0.1	GO:0036374	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.0	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.0	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.0	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.3	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	0.1	GO:0098505	G-rich strand telomeric DNA binding(GO:0098505)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0031005	filamin binding(GO:0031005)
0.0	0.0	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.2	GO:0008320	protein transmembrane transporter activity(GO:0008320)
0.0	0.1	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.1	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.2	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.2	GO:0010181	FMN binding(GO:0010181)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.0	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.0	0.0	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0	0.1	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	PID ALK2 PATHWAY	ALK2 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.3	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.1	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.2	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.3	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix