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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Tbx1_Eomes

Z-value: 0.44

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Transcription factors associated with Tbx1_Eomes

Gene Symbol	Gene ID	Gene Info
Tbx1 Ensembl NCBI MGI UniProt	ENSMUSG00000009097.9	Tbx1
Eomes Ensembl NCBI MGI UniProt	ENSMUSG00000032446.8	Eomes

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Eomes	chr9_118476305_118476456	1832	0.258459	0.27	4.0e-02	Click!
Eomes	chr9_118482050_118482392	3360	0.172105	-0.24	6.8e-02	Click!
Eomes	chr9_118476583_118478215	813	0.531257	0.24	6.9e-02	Click!
Eomes	chr9_118478372_118479858	254	0.887315	0.19	1.4e-01	Click!
Eomes	chr9_118481236_118481395	2454	0.206561	-0.17	1.8e-01	Click!
Tbx1	chr16_18589901_18590901	270	0.835432	0.53	1.7e-05	Click!
Tbx1	chr16_18587715_18589011	445	0.727351	0.51	3.7e-05	Click!
Tbx1	chr16_18585593_18587306	520	0.677503	0.46	2.1e-04	Click!
Tbx1	chr16_18585265_18585440	1617	0.259728	0.40	1.7e-03	Click!
Tbx1	chr16_18589340_18589872	798	0.479543	0.33	9.6e-03	Click!

Activity of the Tbx1_Eomes motif across conditions

Conditions sorted by the z-value of the Tbx1_Eomes motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_99709458_99709950	1.42	Cldn18	claudin 18	305	0.84
chr3_19646421_19646748	1.27	Trim55	tripartite motif-containing 55	2076	0.26
chr2_163396102_163396417	1.11	Jph2	junctophilin 2	1690	0.28
chr2_91120847_91121416	1.05	Mybpc3	myosin binding protein C, cardiac	2987	0.16
chr2_163395773_163396078	1.03	Jph2	junctophilin 2	2024	0.24
chr1_34116331_34116653	0.99	Mir6896	microRNA 6896	867	0.57
chr8_61901105_61901625	0.97	Palld	palladin, cytoskeletal associated protein	1304	0.42
chr5_134745620_134746234	0.88	Gm30003	predicted gene, 30003	1115	0.35
chr3_155054087_155054557	0.82	Tnni3k	TNNI3 interacting kinase	1028	0.55
chr2_32318746_32319267	0.79	Mir199b	microRNA 199b	546	0.42
chr13_23913630_23913830	0.78	Slc17a4	solute carrier family 17 (sodium phosphate), member 4	1238	0.27
chr17_81737002_81738450	0.75	Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1	651	0.81
chr2_92140355_92141595	0.75	Phf21a	PHD finger protein 21A	43131	0.11
chr15_12010211_12011091	0.74	Sub1	SUB1 homolog, transcriptional regulator	13668	0.16
chr13_63241575_63242090	0.72	Aopep	aminopeptidase O	1724	0.2
chr15_3580312_3581004	0.70	Ghr	growth hormone receptor	1184	0.57
chr16_87553258_87554074	0.69	Map3k7cl	Map3k7 C-terminal like	336	0.84
chr1_51291546_51292409	0.68	Cavin2	caveolae associated 2	2851	0.27
chr4_141302549_141302700	0.68	Epha2	Eph receptor A2	217	0.88
chrX_152768117_152768457	0.66	Shroom2	shroom family member 2	1174	0.51
chr2_166412306_166412566	0.64	Gm14268	predicted gene 14268	14249	0.21
chr9_44069968_44070511	0.64	Usp2	ubiquitin specific peptidase 2	796	0.33
chr5_75152837_75154692	0.64	Gm42802	predicted gene 42802	111	0.58
chr16_36989294_36990265	0.64	Fbxo40	F-box protein 40	688	0.6
chr8_27261786_27261937	0.63	Eif4ebp1	eukaryotic translation initiation factor 4E binding protein 1	1532	0.26
chr8_25027794_25028434	0.63	Gm16933	predicted gene, 16933	8938	0.12
chr18_35120289_35121263	0.61	Ctnna1	catenin (cadherin associated protein), alpha 1	1334	0.45
chr9_45934543_45935100	0.61	Tagln	transgelin	753	0.43
chr16_44015370_44016774	0.59	Gramd1c	GRAM domain containing 1C	364	0.83
chr10_22470665_22470816	0.58	Gm26585	predicted gene, 26585	17220	0.18
chr10_120900758_120900909	0.58	Gm4473	predicted gene 4473	1676	0.25
chr3_30546274_30547260	0.58	Mecom	MDS1 and EVI1 complex locus	1241	0.35
chr3_49753928_49755610	0.58	Pcdh18	protocadherin 18	695	0.72
chr7_130576739_130577783	0.58	Tacc2	transforming, acidic coiled-coil containing protein 2	177	0.94
chr12_82122852_82123243	0.57	n-R5s62	nuclear encoded rRNA 5S 62	27421	0.18
chr18_53466213_53466522	0.57	Prdm6	PR domain containing 6	1851	0.45
chr5_100844231_100844692	0.57	Gpat3	glycerol-3-phosphate acyltransferase 3	1252	0.27
chr9_119962629_119963694	0.56	Ttc21a	tetratricopeptide repeat domain 21A	1543	0.24
chr10_22471094_22471245	0.56	Gm26585	predicted gene, 26585	17649	0.18
chr19_56120628_56120882	0.55	Gm31912	predicted gene, 31912	14445	0.24
chr8_41040672_41042201	0.55	Mtus1	mitochondrial tumor suppressor 1	430	0.76
chr6_71254405_71254608	0.55	Smyd1	SET and MYND domain containing 1	7726	0.11
chr14_63265100_63265475	0.54	Gata4	GATA binding protein 4	5837	0.19
chr11_97670192_97670699	0.54	Mllt6	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6	5444	0.08
chr3_53043050_53043701	0.53	Gm42901	predicted gene 42901	1620	0.23
chr15_79111462_79112012	0.53	Micall1	microtubule associated monooxygenase, calponin and LIM domain containing -like 1	2407	0.14
chr13_69460904_69461114	0.53	Gm48676	predicted gene, 48676	52991	0.09
chr10_116750858_116751292	0.52	4930579P08Rik	RIKEN cDNA 4930579P08 gene	21822	0.16
chr3_89832920_89834058	0.52	She	src homology 2 domain-containing transforming protein E	2119	0.21
chr5_119742473_119742643	0.52	Tbx3os2	T-box 3, opposite strand 2	51340	0.1
chr1_74748322_74749490	0.52	Prkag3	protein kinase, AMP-activated, gamma 3 non-catalytic subunit	2	0.96
chr7_16892200_16892882	0.52	Gng8	guanine nucleotide binding protein (G protein), gamma 8	220	0.83
chr6_129183729_129184848	0.51	Clec2d	C-type lectin domain family 2, member d	3673	0.14
chr5_137349923_137351747	0.51	Ephb4	Eph receptor B4	322	0.77
chr11_103096614_103097909	0.51	Plcd3	phospholipase C, delta 3	4330	0.13
chr3_132948328_132948925	0.51	Npnt	nephronectin	1188	0.43
chr13_46423537_46423785	0.51	Rbm24	RNA binding motif protein 24	1839	0.41
chr19_53557067_53557881	0.51	Gm50394	predicted gene, 50394	27819	0.11
chr2_35623965_35624326	0.50	Dab2ip	disabled 2 interacting protein	1985	0.37
chr14_58428834_58429409	0.50	Gm33321	predicted gene, 33321	128139	0.05
chr8_57324709_57326732	0.49	Hand2os1	Hand2, opposite strand 1	1487	0.3
chr9_79990471_79990814	0.49	Filip1	filamin A interacting protein 1	12838	0.16
chr2_35588919_35589070	0.48	Dab2ip	disabled 2 interacting protein	6154	0.2
chr14_74852987_74853831	0.48	Lrch1	leucine-rich repeats and calponin homology (CH) domain containing 1	31846	0.18
chr6_4005591_4005747	0.48	Gng11	guanine nucleotide binding protein (G protein), gamma 11	1765	0.31
chr6_124925245_124926316	0.48	Mlf2	myeloid leukemia factor 2	5606	0.08
chr4_62755430_62755581	0.47	Gm11211	predicted gene 11211	27968	0.15
chr18_75279035_75279335	0.47	2010010A06Rik	RIKEN cDNA 2010010A06 gene	9998	0.23
chr11_74526613_74527288	0.47	Rap1gap2	RAP1 GTPase activating protein 2	4199	0.25
chr14_25323823_25323974	0.46	Gm26660	predicted gene, 26660	54737	0.12
chr15_31396603_31396758	0.46	Gm49300	predicted gene, 49300	28318	0.11
chr10_80960844_80961038	0.46	Gm3828	predicted gene 3828	6231	0.1
chr12_84643018_84643308	0.46	Vrtn	vertebrae development associated	267	0.89
chr4_133040822_133040973	0.46	Ahdc1	AT hook, DNA binding motif, containing 1	1404	0.43
chr14_26439572_26439816	0.45	Slmap	sarcolemma associated protein	473	0.78
chr8_57340613_57341952	0.45	5033428I22Rik	RIKEN cDNA 5033428I22 gene	482	0.73
chr16_77569814_77569965	0.45	Gm37606	predicted gene, 37606	8239	0.11
chr6_48839906_48841160	0.44	Tmem176b	transmembrane protein 176B	62	0.82
chr3_38015645_38016389	0.44	Gm22899	predicted gene, 22899	20782	0.16
chr17_86754057_86754608	0.44	Epas1	endothelial PAS domain protein 1	632	0.71
chr5_140890731_140891173	0.44	Card11	caspase recruitment domain family, member 11	8747	0.24
chr13_46424277_46424435	0.44	Rbm24	RNA binding motif protein 24	2534	0.34
chr15_83526325_83527694	0.43	Bik	BCL2-interacting killer	137	0.93
chr18_3274616_3274842	0.43	Crem	cAMP responsive element modulator	6349	0.23
chr15_89137295_89137649	0.43	Mapk12	mitogen-activated protein kinase 12	28	0.94
chr13_102036243_102036435	0.43	Gm38133	predicted gene, 38133	79696	0.1
chr6_52965535_52965952	0.43	Gm26215	predicted gene, 26215	44789	0.14
chr19_56507368_56507519	0.42	Plekhs1	pleckstrin homology domain containing, family S member 1	27756	0.15
chr7_19163884_19165719	0.42	Gipr	gastric inhibitory polypeptide receptor	293	0.77
chr12_103336858_103338251	0.42	Gm15523	predicted gene 15523	648	0.43
chr5_144507108_144507703	0.42	Nptx2	neuronal pentraxin 2	38497	0.17
chr19_46448230_46448462	0.42	Sufu	SUFU negative regulator of hedgehog signaling	9560	0.15
chr3_60504423_60505028	0.42	Mbnl1	muscleblind like splicing factor 1	3447	0.29
chr14_118385532_118385782	0.42	Gm5672	predicted gene 5672	9463	0.16
chr16_58685640_58686063	0.41	Cpox	coproporphyrinogen oxidase	7995	0.13
chr5_75046578_75047197	0.40	Gm18593	predicted gene, 18593	1592	0.25
chr5_32990256_32991187	0.40	Gm43693	predicted gene 43693	6151	0.16
chr5_53274000_53274222	0.40	Smim20	small integral membrane protein 20	3007	0.24
chr14_36917800_36917970	0.40	Ccser2	coiled-coil serine rich 2	1448	0.48
chr18_84089861_84090362	0.39	Zadh2	zinc binding alcohol dehydrogenase, domain containing 2	1440	0.33
chr6_112728907_112729181	0.39	Rad18	RAD18 E3 ubiquitin protein ligase	32358	0.16
chr3_32822040_32822406	0.39	Usp13	ubiquitin specific peptidase 13 (isopeptidase T-3)	4512	0.22
chr11_18870055_18872175	0.39	8430419K02Rik	RIKEN cDNA 8430419K02 gene	1040	0.49
chr2_26585065_26586013	0.39	Egfl7	EGF-like domain 7	1091	0.24
chr17_69120419_69121537	0.39	Epb41l3	erythrocyte membrane protein band 4.1 like 3	6022	0.31
chr4_154630838_154632339	0.39	Prdm16	PR domain containing 16	5209	0.14
chr4_43763346_43763579	0.39	Olfr269-ps1	olfactory receptor 269, pseudogene 1	4315	0.1
chr7_100657972_100658903	0.38	Plekhb1	pleckstrin homology domain containing, family B (evectins) member 1	15	0.96
chr11_54962647_54963034	0.38	Tnip1	TNFAIP3 interacting protein 1	69	0.97
chr8_126587716_126588216	0.38	Irf2bp2	interferon regulatory factor 2 binding protein 2	6020	0.24
chr18_54452409_54453689	0.38	Gm50361	predicted gene, 50361	23716	0.19
chr10_118839718_118840226	0.38	Gm47434	predicted gene, 47434	4866	0.15
chr9_120619342_120620352	0.38	Gm39456	predicted gene, 39456	452	0.76
chr6_24721472_24721728	0.37	Hyal6	hyaluronoglucosaminidase 6	11645	0.17
chr12_31270509_31272027	0.37	Lamb1	laminin B1	5388	0.14
chr4_83048506_83049199	0.37	Frem1	Fras1 related extracellular matrix protein 1	3315	0.28
chr9_109065033_109065184	0.37	Atrip	ATR interacting protein	285	0.8
chr15_103383151_103383913	0.37	Gm37322	predicted gene, 37322	5461	0.13
chr10_61906333_61906511	0.37	Col13a1	collagen, type XIII, alpha 1	28030	0.17
chr1_153329741_153330128	0.37	Lamc1	laminin, gamma 1	2852	0.24
chr5_73231934_73232445	0.37	Gm17207	predicted gene 17207	19546	0.1
chr11_95841518_95842457	0.37	Abi3	ABI gene family, member 3	111	0.73
chr2_156717216_156718150	0.37	Dlgap4	DLG associated protein 4	2889	0.18
chr4_9606607_9606758	0.37	Asph	aspartate-beta-hydroxylase	10993	0.25
chr17_93437013_93437164	0.37	Gm50001	predicted gene, 50001	45390	0.17
chr8_124943393_124943545	0.37	Egln1	egl-9 family hypoxia-inducible factor 1	5855	0.15
chr12_83770139_83771096	0.36	Papln	papilin, proteoglycan-like sulfated glycoprotein	6955	0.12
chr8_84558613_84558764	0.36	Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	11594	0.17
chr1_189782721_189783385	0.36	Ptpn14	protein tyrosine phosphatase, non-receptor type 14	3583	0.24
chr8_69023381_69023534	0.36	Gm15716	predicted gene 15716	21297	0.15
chr1_165706603_165708435	0.36	Rcsd1	RCSD domain containing 1	529	0.64
chr2_32311532_32312331	0.36	Dnm1	dynamin 1	958	0.33
chr8_33916300_33917561	0.36	Rbpms	RNA binding protein gene with multiple splicing	12346	0.17
chr14_49244860_49245366	0.36	ccdc198	coiled-coil domain containing 198	284	0.89
chr6_22297902_22298203	0.36	Wnt16	wingless-type MMTV integration site family, member 16	9191	0.23
chr15_101411658_101413570	0.35	Krt7	keratin 7	165	0.64
chr17_78676930_78677295	0.35	Strn	striatin, calmodulin binding protein	7240	0.21
chr5_149312765_149313642	0.35	Gm19719	predicted gene, 19719	25335	0.09
chr15_51854075_51854251	0.35	Eif3h	eukaryotic translation initiation factor 3, subunit H	11291	0.17
chr6_48647599_48648258	0.35	Gimap8	GTPase, IMAP family member 8	544	0.53
chr11_103101106_103101632	0.35	Plcd3	phospholipase C, delta 3	222	0.58
chr2_181241290_181242534	0.35	Helz2	helicase with zinc finger 2, transcriptional coactivator	51	0.95
chr2_91125839_91126091	0.35	Mybpc3	myosin binding protein C, cardiac	7821	0.12
chr4_137476144_137477534	0.35	Hspg2	perlecan (heparan sulfate proteoglycan 2)	8036	0.14
chr3_98245804_98245958	0.34	Gm42821	predicted gene 42821	2718	0.21
chr13_41345830_41346374	0.34	Nedd9	neural precursor cell expressed, developmentally down-regulated gene 9	13145	0.14
chr1_98132044_98132246	0.34	1810006J02Rik	RIKEN cDNA 1810006J02 gene	678	0.7
chr5_147722674_147723044	0.34	Flt1	FMS-like tyrosine kinase 1	3129	0.27
chr12_110504246_110504860	0.34	Gm19605	predicted gene, 19605	18345	0.15
chr5_100214874_100215472	0.34	2310034O05Rik	RIKEN cDNA 2310034O05 gene	4465	0.21
chr5_147723576_147724353	0.34	Flt1	FMS-like tyrosine kinase 1	2024	0.35
chr10_22813360_22814229	0.34	Gm10824	predicted gene 10824	1955	0.28
chr18_68058494_68058645	0.34	Gm41764	predicted gene, 41764	59805	0.12
chr3_82141940_82142375	0.33	Gucy1a1	guanylate cyclase 1, soluble, alpha 1	2916	0.3
chr1_38629122_38629273	0.33	Aff3	AF4/FMR2 family, member 3	1996	0.42
chr8_54571415_54571982	0.33	Asb5	ankyrin repeat and SOCs box-containing 5	272	0.9
chr17_34580979_34581380	0.33	Notch4	notch 4	2703	0.08
chr17_35725752_35726163	0.33	Gm20443	predicted gene 20443	13849	0.08
chr4_19576297_19576523	0.32	Rmdn1	regulator of microtubule dynamics 1	1203	0.48
chr6_15638549_15638700	0.32	Gm44039	predicted gene, 44039	2500	0.4
chr6_115984719_115988278	0.32	Plxnd1	plexin D1	8507	0.15
chr13_93307758_93308718	0.32	Homer1	homer scaffolding protein 1	204	0.92
chr12_56298063_56298592	0.32	Gm47682	predicted gene, 47682	43929	0.1
chr4_45896655_45896836	0.32	Ccdc180	coiled-coil domain containing 180	5893	0.19
chr14_101510884_101511350	0.32	Tbc1d4	TBC1 domain family, member 4	3791	0.3
chr18_53249928_53250416	0.32	Snx24	sorting nexing 24	4403	0.25
chr12_84873778_84874595	0.32	D030025P21Rik	RIKEN cDNA D030025P21 gene	1583	0.26
chr9_111119102_111119253	0.32	Lrrfip2	leucine rich repeat (in FLII) interacting protein 2	252	0.9
chr9_123480978_123481680	0.32	Limd1	LIM domains containing 1	719	0.66
chr7_4515813_4516413	0.32	Tnnt1	troponin T1, skeletal, slow	109	0.91
chr18_61785451_61786937	0.32	Afap1l1	actin filament associated protein 1-like 1	417	0.83
chr15_102249163_102250297	0.32	Rarg	retinoic acid receptor, gamma	616	0.54
chr5_101239366_101239752	0.31	Cycs-ps2	cytochrome c, pseudogene 2	66019	0.13
chr1_97975537_97975875	0.31	Pam	peptidylglycine alpha-amidating monooxygenase	1362	0.45
chr16_85546798_85547372	0.31	Cyyr1	cysteine and tyrosine-rich protein 1	3332	0.28
chr11_108758258_108758409	0.31	Cep112	centrosomal protein 112	6128	0.22
chr4_9184182_9184333	0.31	Gm23423	predicted gene, 23423	25746	0.23
chr11_99042414_99042858	0.31	Igfbp4	insulin-like growth factor binding protein 4	450	0.73
chr10_18432775_18433290	0.31	Nhsl1	NHS-like 1	25357	0.21
chr3_95991778_95991929	0.31	Plekho1	pleckstrin homology domain containing, family O member 1	3815	0.14
chr7_19011655_19012657	0.31	Irf2bp1	interferon regulatory factor 2 binding protein 1	8112	0.07
chr2_148037835_148038211	0.31	9030622O22Rik	RIKEN cDNA 9030622O22 gene	247	0.91
chr6_99023814_99025127	0.31	Foxp1	forkhead box P1	3521	0.33
chr10_13092588_13092795	0.31	Plagl1	pleiomorphic adenoma gene-like 1	1678	0.4
chr14_69053224_69053475	0.31	Gm41192	predicted gene, 41192	23697	0.16
chr9_53935727_53936526	0.31	Elmod1	ELMO/CED-12 domain containing 1	708	0.71
chr11_114478869_114479221	0.31	4932435O22Rik	RIKEN cDNA 4932435O22 gene	30185	0.2
chr8_121130074_121130554	0.30	Foxl1	forkhead box L1	2374	0.2
chr2_144676648_144676927	0.30	Dtd1	D-tyrosyl-tRNA deacylase 1	1311	0.47
chr1_188011031_188011182	0.30	9330162B11Rik	RIKEN cDNA 9330162B11 gene	2116	0.38
chr2_145787122_145787273	0.30	Rin2	Ras and Rab interactor 2	1035	0.61
chr19_20725054_20725278	0.30	Aldh1a7	aldehyde dehydrogenase family 1, subfamily A7	2396	0.39
chr15_103182225_103182894	0.30	Smug1	single-strand selective monofunctional uracil DNA glycosylase	15467	0.11
chr17_66404980_66405904	0.30	Gm4705	predicted gene 4705	8542	0.17
chr6_51173127_51174365	0.30	Mir148a	microRNA 148a	96164	0.07
chr2_35627849_35628114	0.29	Dab2ip	disabled 2 interacting protein	5821	0.24
chr1_19241815_19242084	0.29	Gm28340	predicted gene 28340	776	0.67
chr11_53132369_53132523	0.29	Gm11186	predicted gene 11186	12390	0.23
chr12_28998072_28998252	0.29	Gm23342	predicted gene, 23342	37132	0.17
chr19_44726477_44726822	0.29	Gm35610	predicted gene, 35610	13230	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx1_Eomes

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.2	GO:0071847	TNFSF11-mediated signaling pathway(GO:0071847)
0.2	0.6	GO:0048320	axial mesoderm formation(GO:0048320)
0.2	0.5	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1	0.5	GO:1903847	regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1	0.6	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
0.1	0.4	GO:2001199	negative regulation of dendritic cell differentiation(GO:2001199)
0.1	0.5	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.1	0.5	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.1	0.4	GO:0046449	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.1	0.3	GO:0072275	metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.1	0.3	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1	0.1	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.1	0.1	GO:0002339	B cell selection(GO:0002339)
0.1	0.2	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.1	0.3	GO:1904469	positive regulation of tumor necrosis factor secretion(GO:1904469)
0.1	0.2	GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.1	0.4	GO:0071680	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.1	0.3	GO:0048625	myoblast fate commitment(GO:0048625)
0.1	0.6	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.1	0.1	GO:0038161	prolactin signaling pathway(GO:0038161)
0.1	0.2	GO:0032074	negative regulation of nuclease activity(GO:0032074)
0.1	0.2	GO:0042427	serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1	0.2	GO:0032439	endosome localization(GO:0032439)
0.1	0.2	GO:0030091	protein repair(GO:0030091)
0.1	0.1	GO:1900425	negative regulation of defense response to bacterium(GO:1900425)
0.1	0.5	GO:0045217	cell-cell junction maintenance(GO:0045217)
0.1	0.2	GO:0032474	otolith morphogenesis(GO:0032474)
0.1	0.1	GO:2001027	negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1	0.1	GO:0033122	negative regulation of purine nucleotide catabolic process(GO:0033122)
0.1	0.2	GO:0055118	negative regulation of cardiac muscle contraction(GO:0055118)
0.1	0.2	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.1	0.4	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.1	0.2	GO:0061325	cell proliferation involved in outflow tract morphogenesis(GO:0061325)
0.1	0.2	GO:1990928	response to amino acid starvation(GO:1990928)
0.1	0.2	GO:1901552	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1	0.2	GO:0019659	fermentation(GO:0006113) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.0	0.1	GO:0032289	central nervous system myelin formation(GO:0032289)
0.0	0.3	GO:0003010	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.2	GO:0046416	D-amino acid metabolic process(GO:0046416)
0.0	0.5	GO:0086069	bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.3	GO:0048597	post-embryonic camera-type eye morphogenesis(GO:0048597)
0.0	0.2	GO:0031034	myosin filament assembly(GO:0031034)
0.0	0.1	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.3	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.0	0.2	GO:0044027	hypermethylation of CpG island(GO:0044027)
0.0	0.2	GO:0060024	rhythmic synaptic transmission(GO:0060024)
0.0	0.0	GO:0034331	cell junction maintenance(GO:0034331)
0.0	0.2	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.1	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.5	GO:0071803	positive regulation of podosome assembly(GO:0071803)
0.0	0.3	GO:2001256	regulation of store-operated calcium entry(GO:2001256)
0.0	0.1	GO:0010360	negative regulation of anion channel activity(GO:0010360)
0.0	0.4	GO:0009071	serine family amino acid catabolic process(GO:0009071)
0.0	0.3	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.1	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.0	0.1	GO:0032672	regulation of interleukin-3 production(GO:0032672)
0.0	0.2	GO:1903423	positive regulation of synaptic vesicle recycling(GO:1903423)
0.0	0.7	GO:0045475	locomotor rhythm(GO:0045475)
0.0	0.1	GO:0071896	protein localization to adherens junction(GO:0071896)
0.0	0.1	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.0	0.1	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0	0.1	GO:0072566	chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0	0.2	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.2	GO:2000504	positive regulation of blood vessel remodeling(GO:2000504)
0.0	0.1	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.1	GO:0018197	peptidyl-aspartic acid modification(GO:0018197)
0.0	0.1	GO:0003166	bundle of His development(GO:0003166)
0.0	0.1	GO:0035054	embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0	0.1	GO:0030421	defecation(GO:0030421)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.2	GO:0061158	3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0	0.1	GO:0010982	regulation of high-density lipoprotein particle clearance(GO:0010982)
0.0	0.5	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0	0.1	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.2	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.3	GO:0044068	modulation by symbiont of host cellular process(GO:0044068)
0.0	0.3	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.1	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.4	GO:0043584	nose development(GO:0043584)
0.0	0.1	GO:2000118	regulation of sodium-dependent phosphate transport(GO:2000118)
0.0	0.0	GO:0098911	regulation of ventricular cardiac muscle cell action potential(GO:0098911)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.1	GO:0010693	negative regulation of alkaline phosphatase activity(GO:0010693)
0.0	0.1	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.0	0.1	GO:0090259	regulation of retinal ganglion cell axon guidance(GO:0090259)
0.0	0.1	GO:0071314	cellular response to cocaine(GO:0071314)
0.0	0.5	GO:0010758	regulation of macrophage chemotaxis(GO:0010758)
0.0	0.1	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0	0.1	GO:0090403	oxidative stress-induced premature senescence(GO:0090403)
0.0	0.1	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0	0.1	GO:1903977	positive regulation of glial cell migration(GO:1903977)
0.0	0.0	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.2	GO:0008063	Toll signaling pathway(GO:0008063)
0.0	0.1	GO:0003219	cardiac right ventricle formation(GO:0003219)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0042117	monocyte activation(GO:0042117)
0.0	0.2	GO:0048012	hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.0	0.1	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.0	0.1	GO:1905063	regulation of vascular smooth muscle cell differentiation(GO:1905063) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.0	0.1	GO:0032696	negative regulation of interleukin-13 production(GO:0032696)
0.0	0.1	GO:0060160	negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.0	0.1	GO:0072513	positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0	0.1	GO:0046643	regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.0	0.0	GO:0045472	response to ether(GO:0045472)
0.0	0.1	GO:0002175	protein localization to paranode region of axon(GO:0002175)
0.0	0.1	GO:0008582	regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.0	0.1	GO:1903818	positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0	0.1	GO:0036394	amylase secretion(GO:0036394)
0.0	0.1	GO:0021898	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.1	GO:2001260	regulation of semaphorin-plexin signaling pathway(GO:2001260)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.0	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.0	0.1	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0016095	polyprenol catabolic process(GO:0016095)
0.0	0.1	GO:0060486	Clara cell differentiation(GO:0060486)
0.0	0.1	GO:0043137	DNA replication, removal of RNA primer(GO:0043137)
0.0	0.1	GO:0035962	response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
0.0	0.0	GO:1903140	regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140)
0.0	0.1	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
0.0	0.2	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.0	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0	0.2	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0	0.0	GO:0072008	glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.0	0.1	GO:0031339	negative regulation of vesicle fusion(GO:0031339)
0.0	0.0	GO:0060336	negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.0	0.1	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.1	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0	0.1	GO:0061146	Peyer's patch morphogenesis(GO:0061146)
0.0	0.2	GO:0014733	regulation of skeletal muscle adaptation(GO:0014733)
0.0	0.1	GO:0019287	isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0	0.0	GO:0002159	desmosome assembly(GO:0002159)
0.0	0.0	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0	0.1	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.0	0.0	GO:0070103	regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.0	0.1	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0	0.1	GO:0071288	cellular response to mercury ion(GO:0071288)
0.0	0.1	GO:0048550	negative regulation of pinocytosis(GO:0048550)
0.0	0.0	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.0	0.2	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.1	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.0	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.1	GO:0010482	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0	0.1	GO:0042636	negative regulation of hair cycle(GO:0042636)
0.0	0.1	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	0.1	GO:0045110	intermediate filament bundle assembly(GO:0045110)
0.0	0.1	GO:0006677	glycosylceramide metabolic process(GO:0006677)
0.0	0.1	GO:0051835	positive regulation of synapse structural plasticity(GO:0051835)
0.0	0.0	GO:2000370	positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0	0.1	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.0	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.0	0.1	GO:0061074	regulation of neural retina development(GO:0061074)
0.0	0.1	GO:0071801	regulation of podosome assembly(GO:0071801)
0.0	0.0	GO:2001198	regulation of dendritic cell differentiation(GO:2001198)
0.0	0.0	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.1	GO:0008090	retrograde axonal transport(GO:0008090)
0.0	0.1	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0	0.0	GO:0050904	diapedesis(GO:0050904)
0.0	0.5	GO:0005978	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0	0.0	GO:0060978	angiogenesis involved in coronary vascular morphogenesis(GO:0060978)
0.0	0.0	GO:0009173	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.1	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.1	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0	0.0	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.1	GO:0019370	leukotriene biosynthetic process(GO:0019370)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.2	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.0	GO:0060931	sinoatrial node cell development(GO:0060931)
0.0	0.0	GO:0030035	microspike assembly(GO:0030035)
0.0	0.1	GO:0070086	ubiquitin-dependent endocytosis(GO:0070086)
0.0	0.0	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.2	GO:0034497	protein localization to pre-autophagosomal structure(GO:0034497)
0.0	0.1	GO:0003091	renal water homeostasis(GO:0003091)
0.0	0.0	GO:0003222	ventricular trabecula myocardium morphogenesis(GO:0003222)
0.0	0.0	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.1	GO:0035810	positive regulation of urine volume(GO:0035810)
0.0	0.1	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.0	0.1	GO:0061042	vascular wound healing(GO:0061042)
0.0	0.0	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0	0.1	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:1901897	regulation of relaxation of cardiac muscle(GO:1901897)
0.0	0.2	GO:0003301	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0	0.1	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.1	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.0	GO:0007468	regulation of rhodopsin gene expression(GO:0007468)
0.0	0.2	GO:0060716	labyrinthine layer blood vessel development(GO:0060716)
0.0	0.0	GO:0001983	baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.0	0.1	GO:0010890	positive regulation of sequestering of triglyceride(GO:0010890)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.0	GO:0090315	negative regulation of protein targeting to membrane(GO:0090315)
0.0	0.2	GO:0071474	cellular hyperosmotic response(GO:0071474)
0.0	0.0	GO:0036506	maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0	0.0	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.0	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.2	GO:0042573	retinoic acid metabolic process(GO:0042573)
0.0	0.1	GO:0060481	lobar bronchus epithelium development(GO:0060481)
0.0	0.0	GO:2001016	positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0	0.1	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.2	GO:0010842	retina layer formation(GO:0010842)
0.0	0.0	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.0	GO:0030913	paranodal junction assembly(GO:0030913)
0.0	0.0	GO:1901979	regulation of inward rectifier potassium channel activity(GO:1901979)
0.0	0.0	GO:0032621	interleukin-18 production(GO:0032621)
0.0	0.0	GO:0006532	aspartate biosynthetic process(GO:0006532)
0.0	0.0	GO:1902990	telomere maintenance via semi-conservative replication(GO:0032201) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0	0.0	GO:0001927	exocyst assembly(GO:0001927)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902177)
0.0	0.0	GO:0033092	positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0	0.0	GO:0060128	corticotropin hormone secreting cell differentiation(GO:0060128)
0.0	0.1	GO:0035721	intraciliary retrograde transport(GO:0035721)
0.0	0.0	GO:0060509	Type I pneumocyte differentiation(GO:0060509)
0.0	0.0	GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.1	GO:0097320	membrane tubulation(GO:0097320)
0.0	0.0	GO:0015746	tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0	0.0	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.4	GO:0010830	regulation of myotube differentiation(GO:0010830)
0.0	0.0	GO:0090230	regulation of centromere complex assembly(GO:0090230)
0.0	0.1	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0072673	lamellipodium morphogenesis(GO:0072673)
0.0	0.1	GO:0035584	calcium-mediated signaling using intracellular calcium source(GO:0035584)
0.0	0.0	GO:0019482	beta-alanine metabolic process(GO:0019482)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.1	0.3	GO:0043259	laminin-10 complex(GO:0043259)
0.1	0.4	GO:0005915	zonula adherens(GO:0005915)
0.1	0.2	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.1	0.2	GO:0071953	elastic fiber(GO:0071953)
0.1	0.4	GO:0030314	junctional membrane complex(GO:0030314)
0.0	0.1	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.2	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.3	GO:0005861	troponin complex(GO:0005861)
0.0	0.4	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.3	GO:0045277	respiratory chain complex IV(GO:0045277)
0.0	0.6	GO:0002102	podosome(GO:0002102)
0.0	0.2	GO:0043219	lateral loop(GO:0043219)
0.0	0.2	GO:0045179	apical cortex(GO:0045179)
0.0	0.3	GO:0031332	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.1	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	0.2	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.1	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	0.4	GO:0043034	costamere(GO:0043034)
0.0	0.7	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.1	GO:0019815	B cell receptor complex(GO:0019815)
0.0	0.1	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.1	GO:0034991	nuclear meiotic cohesin complex(GO:0034991)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.0	GO:0005914	spot adherens junction(GO:0005914)
0.0	1.7	GO:0005923	bicellular tight junction(GO:0005923)
0.0	0.0	GO:0030478	actin cap(GO:0030478)
0.0	0.1	GO:0030991	intraciliary transport particle A(GO:0030991)
0.0	0.2	GO:0043196	varicosity(GO:0043196)
0.0	0.0	GO:0036195	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0	0.0	GO:0031523	Myb complex(GO:0031523)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.7	GO:0014704	intercalated disc(GO:0014704)
0.0	0.0	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.0	0.0	GO:0097427	microtubule bundle(GO:0097427)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.1	GO:0097452	GAIT complex(GO:0097452)
0.0	0.2	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.0	GO:0097451	glial limiting end-foot(GO:0097451)
0.0	0.1	GO:0001674	female germ cell nucleus(GO:0001674)
0.0	0.2	GO:0001741	XY body(GO:0001741)
0.0	0.2	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0035686	sperm fibrous sheath(GO:0035686)
0.0	0.1	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.0	GO:0000802	transverse filament(GO:0000802)
0.0	0.0	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.1	0.3	GO:0031802	type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1	0.5	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.1	0.3	GO:0031014	troponin T binding(GO:0031014)
0.1	0.5	GO:0031013	troponin I binding(GO:0031013)
0.1	0.2	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.1	0.4	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1	0.2	GO:0070573	metallodipeptidase activity(GO:0070573)
0.1	0.2	GO:0001069	regulatory region RNA binding(GO:0001069)
0.1	0.9	GO:0005003	ephrin receptor activity(GO:0005003)
0.1	0.2	GO:0016842	amidine-lyase activity(GO:0016842)
0.1	0.7	GO:0070300	phosphatidic acid binding(GO:0070300)
0.1	0.2	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1	0.2	GO:0042731	PH domain binding(GO:0042731)
0.0	0.2	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.3	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
0.0	0.3	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.3	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0	0.2	GO:0070191	methionine-R-sulfoxide reductase activity(GO:0070191)
0.0	0.2	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0034739	histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.0	0.0	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.0	0.1	GO:0008732	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0	0.1	GO:0004945	angiotensin type II receptor activity(GO:0004945)
0.0	0.1	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.4	GO:0051400	BH domain binding(GO:0051400)
0.0	0.3	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.4	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.4	GO:0004707	MAP kinase activity(GO:0004707)
0.0	0.4	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.1	GO:0004052	arachidonate 12-lipoxygenase activity(GO:0004052)
0.0	0.1	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.1	GO:0036033	mediator complex binding(GO:0036033)
0.0	0.1	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0	0.2	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0	0.6	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.2	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.1	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.0	0.1	GO:0003840	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.0	0.1	GO:0097322	7SK snRNA binding(GO:0097322)
0.0	0.1	GO:0005329	dopamine transmembrane transporter activity(GO:0005329)
0.0	0.1	GO:1990254	keratin filament binding(GO:1990254)
0.0	0.1	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.0	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.1	GO:0051032	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.9	GO:0017046	peptide hormone binding(GO:0017046)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.0	0.5	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.1	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.1	GO:0031750	D3 dopamine receptor binding(GO:0031750)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.3	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.0	0.3	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0	0.1	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0051431	corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.0	0.0	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.0	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.0	GO:0004942	anaphylatoxin receptor activity(GO:0004942)
0.0	0.0	GO:0047276	N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.0	0.1	GO:0004415	hyalurononglucosaminidase activity(GO:0004415)
0.0	0.1	GO:0097642	calcitonin family receptor activity(GO:0097642)
0.0	0.1	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.0	0.1	GO:0046625	sphingolipid binding(GO:0046625)
0.0	0.0	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.0	0.1	GO:1904288	BAT3 complex binding(GO:1904288)
0.0	0.3	GO:0015002	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.0	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.0	GO:0016649	electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0	0.4	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:1990405	protein antigen binding(GO:1990405)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.0	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0	0.0	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.1	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0046977	TAP binding(GO:0046977)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.2	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0	0.0	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.0	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.0	GO:0038064	collagen receptor activity(GO:0038064)
0.0	0.0	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.0	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0	0.1	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.0	0.0	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.8	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.4	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.6	PID EPHB FWD PATHWAY	EPHB forward signaling
0.7	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.5	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.2	PID S1P S1P2 PATHWAY	S1P2 pathway
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.3	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.2	PID ERBB4 PATHWAY	ErbB4 signaling events
0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2	PID RAC1 REG PATHWAY	Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.1	0.6	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.4	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.5	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.4	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	1.2	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.6	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.4	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.7	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.4	REACTOME CELL CELL JUNCTION ORGANIZATION	Genes involved in Cell-cell junction organization
0.0	0.3	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.0	0.5	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.0	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.0	0.1	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.0	0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.2	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	0.2	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.0	0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.2	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	0.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.2	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.1	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction