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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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Results for Tbx20

Z-value: 0.68

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Transcription factors associated with Tbx20

Gene Symbol	Gene ID	Gene Info
Tbx20 Ensembl NCBI MGI UniProt	ENSMUSG00000031965.8	T-box 20

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr9_24750162_24750521	Tbx20	19339	0.172676	0.37	3.2e-03	Click!
chr9_24739789_24739940	Tbx20	29816	0.151744	0.34	7.9e-03	Click!
chr9_24768577_24769049	Tbx20	867	0.602051	0.33	9.2e-03	Click!
chr9_24769617_24771807	Tbx20	962	0.556580	0.32	1.1e-02	Click!
chr9_24773249_24774873	Tbx20	223	0.923444	0.30	1.8e-02	Click!

Activity of the Tbx20 motif across conditions

Conditions sorted by the z-value of the Tbx20 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_32684554_32685266	2.38	3425401B19Rik	RIKEN cDNA 3425401B19 gene	362	0.71
chr9_58156326_58158409	1.83	Islr	immunoglobulin superfamily containing leucine-rich repeat	1178	0.35
chr10_45337719_45337889	1.79	Bves	blood vessel epicardial substance	2032	0.3
chr7_112660648_112660799	1.70	Gm45473	predicted gene 45473	7941	0.16
chr10_5287995_5289689	1.68	Gm23573	predicted gene, 23573	68331	0.12
chr2_139679952_139680200	1.44	Ism1	isthmin 1, angiogenesis inhibitor	1898	0.34
chr9_99709458_99709950	1.41	Cldn18	claudin 18	305	0.84
chr3_145991092_145991594	1.34	Syde2	synapse defective 1, Rho GTPase, homolog 2 (C. elegans)	2328	0.28
chr17_74903463_74903703	1.32	Ttc27	tetratricopeptide repeat domain 27	41662	0.12
chr1_133245733_133247220	1.31	Plekha6	pleckstrin homology domain containing, family A member 6	370	0.84
chr2_180388160_180389480	1.25	Mir1a-1	microRNA 1a-1	228	0.89
chr2_7079530_7079727	1.20	Celf2	CUGBP, Elav-like family member 2	1579	0.52
chr9_14612272_14612966	1.20	Amotl1	angiomotin-like 1	1967	0.22
chr16_95703800_95705386	1.18	Ets2	E26 avian leukemia oncogene 2, 3' domain	1746	0.39
chrX_157699166_157699560	1.18	Smpx	small muscle protein, X-linked	103	0.96
chr16_42907917_42908393	1.17	Zbtb20	zinc finger and BTB domain containing 20	503	0.78
chr14_101841178_101841822	1.14	Lmo7	LIM domain only 7	681	0.79
chr8_126978786_126979425	1.10	Gm38574	predicted gene, 38574	3127	0.19
chr15_57761421_57761679	1.09	9330154K18Rik	RIKEN cDNA 9330154K18 gene	22884	0.19
chr2_92140355_92141595	1.09	Phf21a	PHD finger protein 21A	43131	0.11
chr2_74681727_74681878	1.08	Hoxd11	homeobox D11	521	0.45
chr4_133555894_133556045	1.07	Nr0b2	nuclear receptor subfamily 0, group B, member 2	2593	0.14
chr6_49096738_49097482	1.03	Igf2bp3	insulin-like growth factor 2 mRNA binding protein 3	2899	0.16
chr7_45019658_45019809	1.03	Rras	related RAS viral (r-ras) oncogene	263	0.74
chr6_52174920_52176658	1.01	Hoxaas3	Hoxa cluster antisense RNA 3	554	0.41
chr6_34599135_34600037	0.98	Cald1	caldesmon 1	966	0.58
chr10_126981839_126982215	0.98	Ctdsp2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	2998	0.11
chr8_25225225_25225470	0.97	Tacc1	transforming, acidic coiled-coil containing protein 1	15516	0.19
chr9_115356841_115357705	0.96	Mir467h	microRNA 467h	24546	0.12
chr7_16892200_16892882	0.95	Gng8	guanine nucleotide binding protein (G protein), gamma 8	220	0.83
chr7_100926314_100930096	0.93	Arhgef17	Rho guanine nucleotide exchange factor (GEF) 17	3902	0.17
chr17_12766020_12767485	0.92	Igf2r	insulin-like growth factor 2 receptor	2912	0.17
chr6_97146396_97147185	0.88	Eogt	EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase	994	0.39
chr15_3581853_3582700	0.87	Ghr	growth hormone receptor	320	0.92
chr13_18790213_18790483	0.86	Vps41	VPS41 HOPS complex subunit	10505	0.27
chr10_126391702_126391947	0.84	1700025K04Rik	RIKEN cDNA 1700025K04 gene	19849	0.25
chr12_40016524_40017443	0.84	Arl4a	ADP-ribosylation factor-like 4A	2499	0.29
chr13_112465692_112466190	0.84	Il6st	interleukin 6 signal transducer	1652	0.33
chr16_95453226_95453447	0.81	Erg	ETS transcription factor	5909	0.29
chr4_8236769_8237012	0.81	Gm25355	predicted gene, 25355	1308	0.43
chr11_100931288_100932301	0.80	Stat3	signal transducer and activator of transcription 3	7586	0.15
chr11_45175304_45175455	0.79	Gm12160	predicted gene 12160	14436	0.19
chr14_54575380_54575961	0.77	Ajuba	ajuba LIM protein	1888	0.16
chr4_46664011_46665033	0.76	Tbc1d2	TBC1 domain family, member 2	14313	0.19
chr17_75440969_75441455	0.76	Rasgrp3	RAS, guanyl releasing protein 3	5286	0.29
chr3_107092040_107092191	0.76	Gm27008	predicted gene, 27008	313	0.81
chr5_77126646_77126869	0.75	Gm15831	predicted gene 15831	4409	0.15
chr11_43383698_43384165	0.74	Gm12148	predicted gene 12148	1551	0.33
chr2_48380324_48380475	0.74	Gm25338	predicted gene, 25338	3939	0.26
chr5_114457519_114457716	0.74	Mvk	mevalonate kinase	5197	0.16
chr3_131156467_131156618	0.73	Gm42449	predicted gene 42449	19757	0.17
chr1_135799428_135800706	0.72	Tnni1	troponin I, skeletal, slow 1	234	0.9
chr16_88560099_88560462	0.72	Cldn8	claudin 8	2903	0.2
chr1_187662217_187663036	0.72	Gm37929	predicted gene, 37929	735	0.68
chr5_151107821_151109068	0.71	Stard13	StAR-related lipid transfer (START) domain containing 13	291	0.94
chr15_84131300_84131654	0.69	Gm33432	predicted gene, 33432	4173	0.13
chr4_152115684_152116767	0.67	Tnfrsf25	tumor necrosis factor receptor superfamily, member 25	118	0.94
chr3_137341050_137342448	0.66	Emcn	endomucin	575	0.82
chr1_164461051_164462265	0.66	Gm32391	predicted gene, 32391	784	0.55
chr2_9906124_9906915	0.65	Gm13262	predicted gene 13262	341	0.81
chr15_91703120_91703338	0.64	Lrrk2	leucine-rich repeat kinase 2	30054	0.19
chr7_90231440_90231794	0.63	Gm45220	predicted gene 45220	30339	0.11
chr9_44498132_44499953	0.63	Bcl9l	B cell CLL/lymphoma 9-like	94	0.91
chr15_98603382_98604193	0.63	Adcy6	adenylate cyclase 6	944	0.36
chr11_72408624_72409355	0.63	Smtnl2	smoothelin-like 2	2722	0.18
chr18_35915478_35915629	0.62	C330008A17Rik	RIKEN cDNA C330008A17 gene	2421	0.18
chr1_12718823_12719219	0.61	Sulf1	sulfatase 1	443	0.85
chr2_163377082_163377233	0.60	Jph2	junctophilin 2	20792	0.13
chr2_91125839_91126091	0.59	Mybpc3	myosin binding protein C, cardiac	7821	0.12
chr11_8486434_8486685	0.59	Tns3	tensin 3	17884	0.28
chr2_155313780_155313931	0.58	Pigu	phosphatidylinositol glycan anchor biosynthesis, class U	9163	0.16
chr3_93522538_93523109	0.58	S100a11	S100 calcium binding protein A11	2335	0.17
chr6_30741945_30743001	0.58	Mest	mesoderm specific transcript	384	0.72
chr18_61665808_61666455	0.58	Carmn	cardiac mesoderm enhancer-associated non-coding RNA	594	0.59
chr6_99469204_99469432	0.57	Gm22328	predicted gene, 22328	15384	0.18
chr3_115712293_115713025	0.57	S1pr1	sphingosine-1-phosphate receptor 1	2413	0.28
chr11_76381220_76381371	0.57	Nxn	nucleoredoxin	17773	0.17
chr8_126867391_126867646	0.56	Gm31718	predicted gene, 31718	8920	0.2
chr19_57239099_57239543	0.56	Ablim1	actin-binding LIM protein 1	8	0.98
chr11_55417729_55419811	0.55	Sparc	secreted acidic cysteine rich glycoprotein	1128	0.44
chr5_120777078_120777234	0.55	Oas3	2'-5' oligoadenylate synthetase 3	484	0.47
chr9_43231400_43231766	0.54	Oaf	out at first homolog	6491	0.16
chr1_160833263_160833414	0.54	Gm38060	predicted gene, 38060	5830	0.13
chr13_52100486_52100637	0.54	4921525O09Rik	RIKEN cDNA 4921525O09 gene	2019	0.33
chr6_70723615_70723766	0.54	Igkj5	immunoglobulin kappa joining 5	196	0.69
chr18_53469057_53469955	0.54	Prdm6	PR domain containing 6	3475	0.33
chr6_20264570_20264721	0.53	Gm42581	predicted gene 42581	476592	0.01
chr2_114052280_114052567	0.52	Actc1	actin, alpha, cardiac muscle 1	464	0.75
chr19_6854909_6856205	0.52	Ccdc88b	coiled-coil domain containing 88B	319	0.8
chr3_9827707_9828674	0.51	Gm24786	predicted gene, 24786	1538	0.39
chr18_53462509_53463403	0.51	Prdm6	PR domain containing 6	627	0.8
chr8_76710038_76710189	0.51	Gm27355	predicted gene, 27355	90831	0.09
chr14_120479808_120480690	0.50	Rap2a	RAS related protein 2a	1805	0.45
chr15_102752755_102752906	0.50	Calcoco1	calcium binding and coiled coil domain 1	30652	0.11
chr17_78934273_78934424	0.50	Cebpz	CCAAT/enhancer binding protein zeta	2689	0.17
chr5_24928061_24928212	0.50	Prkag2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	19159	0.15
chr2_147690687_147690838	0.50	A530006G24Rik	RIKEN cDNA A530006G24 gene	19931	0.19
chr12_57547376_57547527	0.49	Foxa1	forkhead box A1	535	0.73
chr8_22506948_22507557	0.49	Slc20a2	solute carrier family 20, member 2	1026	0.46
chr5_148341058_148341274	0.49	Slc7a1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	1563	0.45
chr2_148036751_148037106	0.48	9030622O22Rik	RIKEN cDNA 9030622O22 gene	1342	0.4
chr4_108838068_108838658	0.48	Txndc12	thioredoxin domain containing 12 (endoplasmic reticulum)	3728	0.16
chr17_29030374_29030534	0.48	Gm16196	predicted gene 16196	2114	0.14
chr16_38709025_38709629	0.47	Arhgap31	Rho GTPase activating protein 31	3571	0.19
chr10_110921543_110922443	0.47	Csrp2	cysteine and glycine-rich protein 2	1788	0.28
chr2_180692538_180693057	0.47	Gm22502	predicted gene, 22502	5266	0.13
chr11_96316025_96316970	0.47	Mir10a	microRNA 10a	668	0.4
chr2_180389757_180390438	0.46	Mir1a-1	microRNA 1a-1	1049	0.41
chr19_42936859_42937183	0.46	Hps1	HPS1, biogenesis of lysosomal organelles complex 3 subunit 1	157043	0.03
chr12_59095360_59096062	0.46	Mia2	MIA SH3 domain ER export factor 2	88	0.93
chr9_118082500_118083548	0.46	Azi2	5-azacytidine induced gene 2	23968	0.18
chr11_20914754_20915017	0.46	Gm23681	predicted gene, 23681	22816	0.18
chr2_122298256_122299570	0.46	Duoxa2	dual oxidase maturation factor 2	13	0.88
chr11_30261256_30261407	0.45	Sptbn1	spectrin beta, non-erythrocytic 1	5883	0.23
chr11_19012477_19012923	0.45	Meis1	Meis homeobox 1	698	0.49
chr17_47989101_47989367	0.45	Gm14871	predicted gene 14871	14338	0.14
chrX_7673653_7673804	0.45	Plp2	proteolipid protein 2	2338	0.12
chr13_47148646_47148901	0.43	A930002C04Rik	RIKEN cDNA A930002C04 gene	103	0.95
chr5_140890731_140891173	0.43	Card11	caspase recruitment domain family, member 11	8747	0.24
chr13_112651975_112652409	0.42	Ddx4	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	109	0.96
chr11_89544915_89545658	0.42	Ankfn1	ankyrin-repeat and fibronectin type III domain containing 1	6730	0.32
chr4_29092846_29093062	0.41	Gm11916	predicted gene 11916	2349	0.32
chr11_68956320_68957720	0.41	Arhgef15	Rho guanine nucleotide exchange factor (GEF) 15	460	0.64
chr7_131032506_131032724	0.41	Dmbt1	deleted in malignant brain tumors 1	546	0.79
chr16_96362648_96363004	0.41	Igsf5	immunoglobulin superfamily, member 5	1032	0.37
chr2_32311532_32312331	0.40	Dnm1	dynamin 1	958	0.33
chr3_144617679_144618017	0.40	Rpl9-ps8	ribosomal protein L9, pseudogene 8	8116	0.15
chr17_29368961_29369571	0.40	Fgd2	FYVE, RhoGEF and PH domain containing 2	287	0.85
chr3_153906931_153907082	0.39	Msh4	mutS homolog 4	868	0.37
chr8_123157519_123158497	0.39	Sult5a1	sulfotransferase family 5A, member 1	220	0.84
chr9_123844355_123844506	0.39	Fyco1	FYVE and coiled-coil domain containing 1	176	0.93
chr1_14756748_14757310	0.39	Msc	musculin	1037	0.45
chr17_25102221_25102372	0.38	Telo2	telomere maintenance 2	870	0.42
chr2_32318746_32319267	0.38	Mir199b	microRNA 199b	546	0.42
chr17_56604701_56604852	0.38	Safb	scaffold attachment factor B	417	0.71
chr3_102085891_102086191	0.37	Casq2	calsequestrin 2	374	0.82
chr3_79229375_79229526	0.37	4921511C10Rik	RIKEN cDNA 4921511C10 gene	16531	0.18
chr7_19824650_19824851	0.37	Bcl3	B cell leukemia/lymphoma 3	1980	0.14
chr6_52154157_52154308	0.37	Hotairm1	Hoxa transcript antisense RNA, myeloid-specific 1	2670	0.09
chr12_117743663_117743926	0.37	Rapgef5	Rap guanine nucleotide exchange factor (GEF) 5	3199	0.27
chr5_119829778_119830485	0.36	Gm43050	predicted gene 43050	1660	0.31
chr11_115133328_115133870	0.35	Cd300lf	CD300 molecule like family member F	392	0.78
chr12_70827053_70827698	0.35	Frmd6	FERM domain containing 6	1686	0.31
chr18_37750859_37751188	0.35	Pcdhgb7	protocadherin gamma subfamily B, 7	577	0.38
chr9_22277194_22277360	0.35	Zfp810	zinc finger protein 810	6626	0.09
chr15_102998770_103001153	0.35	Hoxc6	homeobox C6	568	0.54
chr5_41758847_41759075	0.35	Nkx3-2	NK3 homeobox 2	5540	0.25
chr12_69296651_69297715	0.34	Klhdc2	kelch domain containing 2	428	0.72
chr4_130802234_130802571	0.34	Sdc3	syndecan 3	9536	0.11
chr18_44557958_44558665	0.34	Mcc	mutated in colorectal cancers	38795	0.19
chr1_120176211_120176597	0.34	3110009E18Rik	RIKEN cDNA 3110009E18 gene	15924	0.2
chr10_122010922_122011073	0.34	Srgap1	SLIT-ROBO Rho GTPase activating protein 1	36311	0.13
chr8_117493765_117493916	0.33	Plcg2	phospholipase C, gamma 2	4451	0.21
chr4_155839735_155840422	0.33	Mxra8os	matrix-remodelling associated 8, opposite strand	100	0.67
chr13_41251840_41252333	0.33	Smim13	small integral membrane protein 13	2242	0.2
chr10_53343547_53344097	0.33	Gm47644	predicted gene, 47644	412	0.77
chr1_171501506_171502096	0.33	Gm24871	predicted gene, 24871	1362	0.2
chr13_32493561_32493930	0.33	Gm48073	predicted gene, 48073	42670	0.17
chr13_9128006_9128583	0.33	Larp4b	La ribonucleoprotein domain family, member 4B	7921	0.16
chr5_34217945_34218096	0.33	Gm42848	predicted gene 42848	3142	0.14
chr14_6637179_6637341	0.33	Gm3460	predicted gene 3460	14842	0.14
chr4_82930111_82930271	0.33	Frem1	Fras1 related extracellular matrix protein 1	5399	0.25
chr19_43609438_43610955	0.32	Gm20467	predicted gene 20467	429	0.71
chr10_84438288_84438980	0.32	Nuak1	NUAK family, SNF1-like kinase, 1	1963	0.25
chr10_25449303_25449917	0.32	Epb41l2	erythrocyte membrane protein band 4.1 like 2	7999	0.21
chr19_38054245_38054734	0.32	I830134H01Rik	RIKEN cDNA I830134H01 gene	39	0.9
chr6_136873814_136874977	0.32	Mgp	matrix Gla protein	1386	0.26
chr1_19223778_19223929	0.32	Tfap2b	transcription factor AP-2 beta	9974	0.19
chr16_91348159_91348310	0.30	Gm24695	predicted gene, 24695	1550	0.28
chr17_56591227_56591378	0.30	Safb	scaffold attachment factor B	2462	0.16
chr15_103036300_103036759	0.30	Hoxc4	homeobox C4	2134	0.16
chr10_110927145_110928031	0.30	Csrp2	cysteine and glycine-rich protein 2	3613	0.19
chr12_16739495_16739811	0.30	Greb1	gene regulated by estrogen in breast cancer protein	475	0.79
chr6_116651389_116652299	0.30	Depp1	DEPP1 autophagy regulator	1148	0.32
chr16_37882910_37883557	0.30	Gm15725	predicted gene 15725	691	0.61
chr2_150650997_150651161	0.30	Acss1	acyl-CoA synthetase short-chain family member 1	12964	0.12
chr10_79806462_79808470	0.30	Palm	paralemmin	785	0.35
chr11_115416733_115417187	0.30	Atp5h	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D	58	0.93
chr11_88275982_88276133	0.29	Ccdc182	coiled-coil domain containing 182	18001	0.15
chr8_117692115_117692317	0.29	Hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2	9688	0.13
chr16_90405483_90405634	0.29	Hunk	hormonally upregulated Neu-associated kinase	5014	0.2
chr9_98968051_98968202	0.29	Foxl2os	forkhead box L2, opposite strand	12827	0.11
chr17_28272737_28272895	0.29	Ppard	peroxisome proliferator activator receptor delta	697	0.55
chr17_12689035_12689208	0.29	Igf2r	insulin-like growth factor 2 receptor	12158	0.15
chr3_127779635_127780565	0.28	Alpk1	alpha-kinase 1	390	0.77
chr8_62284047_62284979	0.28	Gm2961	predicted gene 2961	90301	0.09
chr12_112490769_112491162	0.28	A530016L24Rik	RIKEN cDNA A530016L24 gene	1491	0.35
chr13_56609245_56610611	0.28	Tgfbi	transforming growth factor, beta induced	342	0.88
chr8_104108186_104108431	0.28	Gm29682	predicted gene, 29682	2435	0.2
chr16_19981596_19982182	0.27	Klhl6	kelch-like 6	1041	0.58
chr11_116821547_116822325	0.27	Mxra7	matrix-remodelling associated 7	6067	0.12
chrX_7316516_7317667	0.27	Clcn5	chloride channel, voltage-sensitive 5	2079	0.26
chr4_129575140_129575515	0.27	Lck	lymphocyte protein tyrosine kinase	1686	0.17
chr6_92071359_92071510	0.27	Fgd5	FYVE, RhoGEF and PH domain containing 5	246	0.91
chr13_58122870_58123670	0.27	Hnrnpa0	heterogeneous nuclear ribonucleoprotein A0	5286	0.14
chr10_22821973_22822241	0.27	Tcf21	transcription factor 21	1933	0.29
chr4_114422836_114422987	0.27	Trabd2b	TraB domain containing 2B	16187	0.28
chr4_8963467_8963668	0.26	Rps18-ps2	ribosomal protein S18, pseudogene 2	22308	0.26
chr7_140954618_140955957	0.26	Gm45717	predicted gene 45717	650	0.32
chr15_6861574_6861725	0.26	Osmr	oncostatin M receptor	12608	0.28

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx20

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.2	GO:1903011	negative regulation of bone development(GO:1903011)
0.2	0.9	GO:0006549	isoleucine metabolic process(GO:0006549)
0.2	0.5	GO:0060931	sinoatrial node cell development(GO:0060931)
0.2	0.5	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1	0.2	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
0.1	0.4	GO:0061144	alveolar secondary septum development(GO:0061144)
0.1	0.5	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.1	0.4	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.1	0.9	GO:0014883	transition between fast and slow fiber(GO:0014883)
0.1	0.6	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1	0.3	GO:0070103	regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.1	0.3	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.1	0.3	GO:0021570	rhombomere 4 development(GO:0021570)
0.1	0.3	GO:0014707	branchiomeric skeletal muscle development(GO:0014707)
0.1	0.2	GO:0042668	auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.1	0.2	GO:2000111	positive regulation of macrophage apoptotic process(GO:2000111)
0.1	0.4	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
0.1	0.3	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1	0.3	GO:2000504	positive regulation of blood vessel remodeling(GO:2000504)
0.1	0.7	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.1	0.3	GO:0071313	cellular response to caffeine(GO:0071313) cellular response to purine-containing compound(GO:0071415)
0.1	1.3	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1	0.2	GO:0051665	membrane raft localization(GO:0051665)
0.1	0.1	GO:0014858	positive regulation of skeletal muscle cell proliferation(GO:0014858)
0.1	0.2	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.9	GO:0043584	nose development(GO:0043584)
0.1	0.2	GO:0060700	regulation of ribonuclease activity(GO:0060700)
0.1	0.2	GO:0015822	ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.1	0.1	GO:0072144	glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.1	0.2	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.1	0.2	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.1	0.2	GO:0002159	desmosome assembly(GO:0002159)
0.0	0.2	GO:0043415	positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0	0.1	GO:0032289	central nervous system myelin formation(GO:0032289)
0.0	0.1	GO:1902988	neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996)
0.0	0.6	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272)
0.0	0.1	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.2	GO:1902774	late endosome to lysosome transport(GO:1902774)
0.0	0.2	GO:0051835	positive regulation of synapse structural plasticity(GO:0051835)
0.0	0.1	GO:0001705	ectoderm formation(GO:0001705)
0.0	0.2	GO:0072513	positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0	0.2	GO:0070589	cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506) cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) chain elongation of O-linked mannose residue(GO:0044845) cellular component macromolecule biosynthetic process(GO:0070589)
0.0	0.2	GO:1903423	positive regulation of synaptic vesicle recycling(GO:1903423)
0.0	0.1	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.2	GO:0003241	growth involved in heart morphogenesis(GO:0003241)
0.0	0.2	GO:0003383	apical constriction(GO:0003383)
0.0	0.1	GO:0019287	isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0	0.2	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.1	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.0	0.3	GO:0003091	renal water homeostasis(GO:0003091)
0.0	0.1	GO:0061343	cell adhesion involved in heart morphogenesis(GO:0061343)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:0010481	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0	0.1	GO:0060160	negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.0	0.1	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.1	GO:0090071	negative regulation of ribosome biogenesis(GO:0090071)
0.0	0.1	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.1	GO:0051031	tRNA transport(GO:0051031)
0.0	0.9	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	0.1	GO:0086023	adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.1	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.2	GO:0021853	cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0	0.1	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.3	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0021569	rhombomere 3 development(GO:0021569)
0.0	0.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.2	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.0	GO:0060686	negative regulation of prostatic bud formation(GO:0060686)
0.0	0.1	GO:0033686	positive regulation of luteinizing hormone secretion(GO:0033686)
0.0	0.2	GO:0071864	positive regulation of cell proliferation in bone marrow(GO:0071864)
0.0	0.1	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.1	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.1	GO:0043416	regulation of skeletal muscle tissue regeneration(GO:0043416)
0.0	0.1	GO:1904263	positive regulation of TORC1 signaling(GO:1904263)
0.0	0.1	GO:0003166	bundle of His development(GO:0003166)
0.0	0.4	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.1	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.1	GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998)
0.0	0.1	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.1	GO:2000053	regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0	0.1	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.0	0.8	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.1	GO:0031034	myosin filament assembly(GO:0031034)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.1	GO:0007494	midgut development(GO:0007494)
0.0	0.6	GO:0010718	positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0	0.1	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.1	GO:0007182	common-partner SMAD protein phosphorylation(GO:0007182)
0.0	0.1	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.1	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0	0.0	GO:0060161	positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.0	0.0	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.3	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.1	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0	0.1	GO:1904683	regulation of metalloendopeptidase activity(GO:1904683)
0.0	0.0	GO:0048850	hypophysis morphogenesis(GO:0048850)
0.0	0.0	GO:0032849	positive regulation of cellular pH reduction(GO:0032849)
0.0	0.1	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.0	GO:0031999	negative regulation of fatty acid beta-oxidation(GO:0031999)
0.0	0.0	GO:0051944	positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.0	0.4	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.1	GO:2000836	androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
0.0	0.1	GO:0098795	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0	0.5	GO:0070328	acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0	0.1	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.3	GO:0015986	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.0	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
0.0	0.0	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.0	GO:0048296	isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296)
0.0	0.1	GO:0048617	embryonic foregut morphogenesis(GO:0048617)
0.0	0.1	GO:0045416	positive regulation of interleukin-8 biosynthetic process(GO:0045416)
0.0	0.0	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0	0.1	GO:0032607	interferon-alpha production(GO:0032607)
0.0	0.0	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:0030210	heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0	0.3	GO:0043536	positive regulation of blood vessel endothelial cell migration(GO:0043536)
0.0	0.2	GO:0001771	immunological synapse formation(GO:0001771)
0.0	0.3	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.0	0.0	GO:0031087	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.0	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0	0.1	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0	0.0	GO:0036118	hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0	0.0	GO:0072162	paramesonephric duct development(GO:0061205) metanephric mesenchymal cell differentiation(GO:0072162)
0.0	0.0	GO:0061055	myotome development(GO:0061055)
0.0	0.0	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.1	GO:0042078	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0	0.0	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.4	GO:0010883	regulation of lipid storage(GO:0010883)
0.0	0.0	GO:0046645	positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645)
0.0	0.0	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.0	GO:0060406	regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406)
0.0	0.0	GO:0043308	eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.0	0.0	GO:0030730	sequestering of triglyceride(GO:0030730)
0.0	0.0	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.1	GO:0042953	lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0	0.3	GO:0001937	negative regulation of endothelial cell proliferation(GO:0001937)
0.0	0.1	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.0	GO:0070278	extracellular matrix constituent secretion(GO:0070278)
0.0	0.0	GO:0002036	regulation of L-glutamate transport(GO:0002036)
0.0	0.1	GO:0021527	spinal cord association neuron differentiation(GO:0021527)
0.0	0.0	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.0	0.0	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.0	GO:2000705	regulation of dense core granule biogenesis(GO:2000705)
0.0	0.2	GO:0045475	locomotor rhythm(GO:0045475)
0.0	0.1	GO:0048069	eye pigmentation(GO:0048069)
0.0	0.5	GO:0030032	lamellipodium assembly(GO:0030032)
0.0	0.2	GO:0032967	positive regulation of collagen biosynthetic process(GO:0032967)
0.0	0.0	GO:1903525	regulation of membrane tubulation(GO:1903525)
0.0	0.0	GO:0035582	sequestering of BMP in extracellular matrix(GO:0035582)
0.0	0.6	GO:0006940	regulation of smooth muscle contraction(GO:0006940)
0.0	0.0	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.1	GO:0005927	muscle tendon junction(GO:0005927)
0.2	0.8	GO:0030478	actin cap(GO:0030478)
0.1	0.3	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.1	0.7	GO:0005861	troponin complex(GO:0005861)
0.1	0.4	GO:0071547	piP-body(GO:0071547)
0.1	0.2	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	0.2	GO:0097418	neurofibrillary tangle(GO:0097418)
0.1	0.3	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.4	GO:0030314	junctional membrane complex(GO:0030314)
0.0	0.1	GO:0097648	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.2	GO:0031502	dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0	0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.3	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.2	GO:0033263	CORVET complex(GO:0033263)
0.0	0.1	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.2	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.1	GO:0032437	cuticular plate(GO:0032437)
0.0	0.1	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	0.3	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.4	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	0.8	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.1	GO:0043293	apoptosome(GO:0043293)
0.0	0.1	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.2	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)
0.0	0.2	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.4	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.1	GO:0043296	apical junction complex(GO:0043296)
0.0	0.2	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.0	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	1.5	GO:0005923	bicellular tight junction(GO:0005923)
0.0	0.2	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.1	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.0	GO:0032127	dense core granule membrane(GO:0032127)
0.0	0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.2	GO:0030057	desmosome(GO:0030057)
0.0	0.8	GO:0042641	actomyosin(GO:0042641)
0.0	0.5	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.0	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0	0.2	GO:0043196	varicosity(GO:0043196)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1	0.4	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	0.3	GO:0016262	protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1	0.2	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.1	0.2	GO:0030943	mitochondrion targeting sequence binding(GO:0030943)
0.1	0.2	GO:0031750	D3 dopamine receptor binding(GO:0031750)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.2	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.2	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.2	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0	0.1	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.2	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.1	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.3	GO:0034211	GTP-dependent protein kinase activity(GO:0034211)
0.0	0.3	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	0.7	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	0.1	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.0	1.0	GO:0042169	SH2 domain binding(GO:0042169)
0.0	0.1	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.1	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.0	0.2	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.5	GO:0030552	cAMP binding(GO:0030552)
0.0	0.1	GO:0071253	connexin binding(GO:0071253)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.4	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.2	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0	0.3	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0	0.1	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.2	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.0	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0005329	dopamine transmembrane transporter activity(GO:0005329)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.3	GO:0046965	retinoid X receptor binding(GO:0046965)
0.0	1.3	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.2	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0042731	PH domain binding(GO:0042731)
0.0	0.2	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.0	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	0.1	GO:0036374	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.0	0.0	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.4	GO:0042805	actinin binding(GO:0042805)
0.0	0.8	GO:0019003	GDP binding(GO:0019003)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.4	GO:0052771	coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0	0.1	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
0.0	0.1	GO:0031014	troponin T binding(GO:0031014)
0.0	0.0	GO:0030628	pre-mRNA 3'-splice site binding(GO:0030628)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.0	GO:0019912	cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.0	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	0.1	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.0	GO:0035877	death effector domain binding(GO:0035877)
0.0	0.4	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.0	0.0	GO:0048763	calcium-induced calcium release activity(GO:0048763)
0.0	0.0	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
0.0	0.5	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.2	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.5	GO:0017022	myosin binding(GO:0017022)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.7	GO:0008013	beta-catenin binding(GO:0008013)
0.0	1.1	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	0.1	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	0.2	GO:0045296	cadherin binding(GO:0045296)
0.0	0.0	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.0	0.0	GO:0016174	NAD(P)H oxidase activity(GO:0016174)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.0	PID RAS PATHWAY	Regulation of Ras family activation
1.2	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
1.0	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.4	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.6	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.3	PID IL27 PATHWAY	IL27-mediated signaling events
0.2	PID NECTIN PATHWAY	Nectin adhesion pathway
0.3	PID AURORA A PATHWAY	Aurora A signaling
0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2	PID S1P S1P1 PATHWAY	S1P1 pathway
0.3	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.7	PID CMYB PATHWAY	C-MYB transcription factor network
0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.1	0.8	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1	0.6	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	1.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.4	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.8	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	1.2	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.0	0.3	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.1	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	0.4	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.1	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.7	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.3	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	1.0	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors

Results for Tbx20

Z-value: 0.68

Motif logo

Transcription factors associated with Tbx20

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Tbx20 motif across conditions

Conditions sorted by the z-value of the Tbx20 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx20

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: