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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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Results for Tfap2e

Z-value: 0.71

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Transcription factors associated with Tfap2e

Gene Symbol	Gene ID	Gene Info
Tfap2e Ensembl NCBI MGI UniProt	ENSMUSG00000042477.7	transcription factor AP-2, epsilon

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr4_126740288_126740466	Tfap2e	4137	0.156133	0.34	8.4e-03	Click!
chr4_126735142_126736537	Tfap2e	401	0.792028	-0.33	9.1e-03	Click!
chr4_126733989_126734295	Tfap2e	2098	0.232339	0.21	1.0e-01	Click!
chr4_126734304_126734958	Tfap2e	1609	0.289741	0.21	1.1e-01	Click!
chr4_126733832_126733983	Tfap2e	2333	0.214920	0.15	2.5e-01	Click!

Activity of the Tfap2e motif across conditions

Conditions sorted by the z-value of the Tfap2e motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_162220626_162221297	2.15	Dnm3os	dynamin 3, opposite strand	1093	0.42
chr12_73042017_73042233	1.38	Six1	sine oculis-related homeobox 1	690	0.71
chr10_3863416_3864702	1.31	Gm16149	predicted gene 16149	5548	0.21
chr12_33955777_33956381	1.15	Twist1	twist basic helix-loop-helix transcription factor 1	1592	0.42
chr3_86541860_86542342	0.88	Lrba	LPS-responsive beige-like anchor	68	0.98
chr8_50916657_50916808	0.87	C130073E24Rik	RIKEN cDNA C130073E24 gene	265	0.96
chr1_172484027_172485046	0.85	Igsf9	immunoglobulin superfamily, member 9	2222	0.17
chr11_101815690_101815909	0.84	Etv4	ets variant 4	30428	0.12
chr18_60646910_60648302	0.71	Synpo	synaptopodin	666	0.69
chr8_12399326_12400483	0.70	Gm25239	predicted gene, 25239	3501	0.16
chr18_79105943_79106581	0.69	Setbp1	SET binding protein 1	3129	0.37
chr5_115438447_115439259	0.68	4930430O22Rik	RIKEN cDNA 4930430O22 gene	2209	0.13
chr11_79661785_79661936	0.68	Rab11fip4	RAB11 family interacting protein 4 (class II)	1298	0.3
chr11_85833878_85836704	0.65	Tbx2	T-box 2	2740	0.17
chr2_30554051_30554283	0.64	Gm14487	predicted gene 14487	19438	0.15
chr18_77563866_77564228	0.63	Rnf165	ring finger protein 165	562	0.8
chr16_93558150_93558964	0.61	Setd4	SET domain containing 4	25451	0.12
chr14_118231082_118232196	0.61	Gm4675	predicted gene 4675	4593	0.14
chr6_6863513_6864355	0.60	Dlx6	distal-less homeobox 6	136	0.91
chr6_112945034_112945954	0.57	Srgap3	SLIT-ROBO Rho GTPase activating protein 3	1260	0.31
chr12_9577276_9578110	0.57	Osr1	odd-skipped related transcription factor 1	3252	0.23
chr10_97566192_97567945	0.57	Lum	lumican	1940	0.32
chr8_75113324_75113614	0.57	Mcm5	minichromosome maintenance complex component 5	3845	0.17
chr9_41378412_41379411	0.56	Mir100hg	Mir100 Mirlet7a-2 Mir125b-1 cluster host gene	2350	0.27
chr11_97626854_97627270	0.55	Epop	elongin BC and polycomb repressive complex 2 associated protein	2640	0.14
chr6_53267728_53268574	0.54	Creb5	cAMP responsive element binding protein 5	19119	0.22
chr17_24521651_24521802	0.53	Traf7	TNF receptor-associated factor 7	2518	0.1
chr14_31124934_31125916	0.52	Smim4	small integral membrane protein 4	3413	0.14
chr4_139142908_139143066	0.52	Hspe1-ps4	heat shock protein 1 (chaperonin 10), pseudogene 4	7210	0.14
chr14_44858459_44859503	0.52	Gm16976	predicted gene, 16976	27	0.85
chr6_77244137_77244322	0.51	Lrrtm1	leucine rich repeat transmembrane neuronal 1	1307	0.55
chr6_30709196_30709388	0.51	Gm14528	predicted gene 14528	10581	0.11
chr1_133187933_133188192	0.51	Plekha6	pleckstrin homology domain containing, family A member 6	6741	0.19
chr15_72033547_72034526	0.50	Col22a1	collagen, type XXII, alpha 1	191	0.97
chr14_54573090_54573690	0.48	Ajuba	ajuba LIM protein	1308	0.24
chr2_39003642_39003858	0.48	Rpl35	ribosomal protein L35	1293	0.23
chr12_111424483_111424634	0.48	Exoc3l4	exocyst complex component 3-like 4	2997	0.16
chr14_122475443_122476757	0.48	Zic2	zinc finger protein of the cerebellum 2	665	0.44
chr2_73356737_73357357	0.47	Gm13703	predicted gene 13703	221	0.89
chr2_167540595_167541629	0.46	Snai1	snail family zinc finger 1	2917	0.16
chr9_98958573_98959491	0.46	Foxl2os	forkhead box L2, opposite strand	3733	0.14
chr3_95931539_95931909	0.46	Anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	1077	0.31
chr9_91404809_91406365	0.45	Gm29478	predicted gene 29478	1113	0.42
chr15_95527528_95528774	0.45	Nell2	NEL-like 2	27	0.99
chr12_108958975_108959883	0.44	Gm47980	predicted gene, 47980	1483	0.33
chr6_100422018_100422496	0.44	Gm23234	predicted gene, 23234	72557	0.09
chr17_34325316_34325467	0.44	H2-Eb2	histocompatibility 2, class II antigen E beta2	274	0.8
chr12_108179845_108180611	0.44	Ccnk	cyclin K	490	0.66
chr1_121527427_121528842	0.43	Htr5b	5-hydroxytryptamine (serotonin) receptor 5B	331	0.84
chr5_111414297_111414695	0.43	Mn1	meningioma 1	2866	0.22
chr10_45783632_45783865	0.43	D030045P18Rik	RIKEN cDNA D030045P18 gene	23814	0.18
chr9_61163718_61163950	0.43	I730028E13Rik	RIKEN cDNA I730028E13 gene	25319	0.14
chr17_29326157_29327438	0.43	Gm46603	predicted gene, 46603	4248	0.12
chr7_25291976_25292552	0.43	Cic	capicua transcriptional repressor	329	0.76
chr14_40894027_40894178	0.43	Sh2d4b	SH2 domain containing 4B	836	0.67
chr17_49816188_49816339	0.43	Gm16555	predicted gene 16555	5562	0.26
chr13_43210781_43210932	0.42	Tbc1d7	TBC1 domain family, member 7	39355	0.15
chr4_139825248_139825758	0.42	Pax7	paired box 7	7504	0.23
chr11_60294712_60295354	0.42	Gm27711	predicted gene, 27711	7791	0.14
chr3_89435022_89435319	0.42	Pbxip1	pre B cell leukemia transcription factor interacting protein 1	1536	0.19
chr8_122615874_122616025	0.41	Trappc2l	trafficking protein particle complex 2-like	4303	0.1
chr7_101833612_101833784	0.41	Gm10602	predicted gene 10602	2805	0.12
chr7_4747695_4747846	0.41	Kmt5c	lysine methyltransferase 5C	1962	0.14
chr2_32307829_32308017	0.40	Dnm1	dynamin 1	2712	0.12
chr13_15464574_15464999	0.40	Gli3	GLI-Kruppel family member GLI3	806	0.46
chr6_42265062_42266248	0.39	Casp2	caspase 2	535	0.62
chr5_137043355_137043506	0.39	Ap1s1	adaptor protein complex AP-1, sigma 1	1977	0.19
chr5_24321335_24322296	0.39	Kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	439	0.73
chr11_53637044_53637520	0.39	Il13	interleukin 13	2580	0.17
chr7_28386729_28387087	0.39	Med29	mediator complex subunit 29	5800	0.08
chr4_19871659_19871930	0.38	Atp6v0d2	ATPase, H+ transporting, lysosomal V0 subunit D2	45146	0.14
chr15_100644899_100645050	0.38	Mir6961	microRNA 6961	4255	0.1
chr17_37196656_37197851	0.38	Olfr94	olfactory receptor 94	758	0.35
chr5_136860922_136861924	0.38	Gm20485	predicted gene 20485	8299	0.14
chr9_61530173_61530451	0.38	Gm34424	predicted gene, 34424	3103	0.31
chr11_119514733_119515649	0.38	Endov	endonuclease V	13213	0.13
chr17_17408831_17408982	0.38	Gm26873	predicted gene, 26873	3087	0.2
chr13_78205305_78205829	0.38	A830082K12Rik	RIKEN cDNA A830082K12 gene	2780	0.19
chr2_174760566_174761903	0.37	Edn3	endothelin 3	182	0.96
chr11_51853445_51853596	0.37	Jade2	jade family PHD finger 2	3605	0.22
chr9_69469003_69469456	0.37	Anxa2	annexin A2	9236	0.12
chr8_123416536_123417431	0.36	Tubb3	tubulin, beta 3 class III	5393	0.08
chr13_53469792_53470715	0.36	Msx2	msh homeobox 2	2821	0.27
chr10_8813926_8814547	0.36	Gm25410	predicted gene, 25410	9911	0.2
chr4_148037756_148037907	0.36	Clcn6	chloride channel, voltage-sensitive 6	731	0.4
chr6_145075061_145076261	0.36	Bcat1	branched chain aminotransferase 1, cytosolic	523	0.72
chr2_167559853_167560205	0.36	Gm11476	predicted gene 11476	6715	0.12
chrX_49484933_49485344	0.36	Arhgap36	Rho GTPase activating protein 36	537	0.82
chr4_11123032_11124084	0.36	Gm11827	predicted gene 11827	400	0.77
chr11_60701603_60702274	0.36	Llgl1	LLGL1 scribble cell polarity complex component	2093	0.12
chr2_93649530_93649681	0.35	Alx4	aristaless-like homeobox 4	7217	0.25
chr4_32923038_32923201	0.35	Ankrd6	ankyrin repeat domain 6	336	0.87
chr9_18292786_18293406	0.35	Chordc1	cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1	708	0.62
chr17_24765085_24765600	0.35	Hs3st6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	12326	0.07
chr3_122518339_122518794	0.34	Bcar3	breast cancer anti-estrogen resistance 3	6080	0.14
chr12_79924950_79925998	0.34	9430078K24Rik	RIKEN cDNA 9430078K24 gene	20	0.98
chr4_95153802_95153953	0.34	Gm28096	predicted gene 28096	2137	0.28
chr14_122477033_122477655	0.34	Zic2	zinc finger protein of the cerebellum 2	756	0.48
chr15_10711072_10711949	0.34	Rai14	retinoic acid induced 14	2030	0.32
chr10_61423139_61423290	0.34	Nodal	nodal	5242	0.12
chr9_40804526_40806209	0.33	Snord14e	small nucleolar RNA, C/D box 14E	619	0.38
chrX_99819606_99819757	0.33	Tmem28	transmembrane protein 28	1340	0.52
chr8_95084589_95084801	0.33	Katnb1	katanin p80 (WD40-containing) subunit B 1	2099	0.17
chr11_98922257_98922979	0.33	Cdc6	cell division cycle 6	2152	0.18
chr10_96955242_96955756	0.33	Gm33981	predicted gene, 33981	3372	0.31
chr8_25070198_25070900	0.33	Plekha2	pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2	20797	0.11
chr4_130544569_130544756	0.33	Nkain1	Na+/K+ transporting ATPase interacting 1	13326	0.24
chr2_157341643_157341794	0.32	Ghrh	growth hormone releasing hormone	4292	0.19
chr15_99601478_99601706	0.32	Aqp6	aquaporin 6	192	0.89
chr10_116760729_116761294	0.32	4930579P08Rik	RIKEN cDNA 4930579P08 gene	31758	0.14
chr3_99261050_99262399	0.32	Gm43120	predicted gene 43120	439	0.81
chr7_16611263_16612711	0.32	Gm29443	predicted gene 29443	1837	0.17
chr5_92998100_92998342	0.32	Gm6450	predicted gene 6450	5610	0.16
chr18_34933820_34933974	0.32	Etf1	eukaryotic translation termination factor 1	1890	0.22
chr2_84741934_84742491	0.32	Mir130a	microRNA 130a	1034	0.27
chr2_92600016_92600773	0.32	Chst1	carbohydrate sulfotransferase 1	687	0.61
chr8_48614074_48614225	0.32	Gm45772	predicted gene 45772	17020	0.26
chr19_21785153_21785677	0.32	Cemip2	cell migration inducing hyaluronidase 2	7027	0.22
chr17_25556052_25557244	0.32	Gm50026	predicted gene, 50026	4565	0.09
chr5_111418246_111419747	0.31	Mn1	meningioma 1	1554	0.34
chr13_110280269_110281178	0.31	Rab3c	RAB3C, member RAS oncogene family	178	0.96
chr12_100998948_100999342	0.31	Gm36756	predicted gene, 36756	6173	0.13
chr19_45795603_45796547	0.31	Kcnip2	Kv channel-interacting protein 2	371	0.82
chr9_22005805_22006085	0.31	Prkcsh	protein kinase C substrate 80K-H	377	0.71
chr17_25935201_25935431	0.31	Pigq	phosphatidylinositol glycan anchor biosynthesis, class Q	249	0.79
chr6_92786590_92787798	0.31	A730049H05Rik	RIKEN cDNA A730049H05 gene	29284	0.19
chr15_103334436_103334587	0.31	Zfp385a	zinc finger protein 385A	184	0.9
chr15_103302622_103303166	0.31	Gm49482	predicted gene, 49482	1829	0.19
chr11_60127277_60127428	0.30	4930412M03Rik	RIKEN cDNA 4930412M03 gene	12122	0.14
chr11_76577733_76577884	0.30	Abr	active BCR-related gene	81	0.97
chr10_57040338_57040864	0.30	Gm36827	predicted gene, 36827	58369	0.13
chr9_44381420_44381612	0.30	Hyou1	hypoxia up-regulated 1	987	0.22
chr7_28151731_28151882	0.30	Gm31024	predicted gene, 31024	17821	0.09
chr17_46618185_46620270	0.30	Ptk7	PTK7 protein tyrosine kinase 7	10277	0.1
chr9_98668581_98668734	0.30	Pisrt1	polled intersex syndrome regulated transcript 1	37609	0.12
chr4_150871780_150871938	0.30	Errfi1	ERBB receptor feedback inhibitor 1	16786	0.12
chr10_115478421_115479410	0.29	Lgr5	leucine rich repeat containing G protein coupled receptor 5	15836	0.19
chr3_99248252_99249856	0.29	Tbx15	T-box 15	4706	0.18
chr6_79538142_79538293	0.29	Gm6261	predicted gene 6261	2991	0.4
chr5_147108738_147108889	0.29	Polr1d	polymerase (RNA) I polypeptide D	3447	0.2
chr2_30687005_30687641	0.29	Gm14486	predicted gene 14486	9312	0.15
chr12_112143792_112144988	0.29	Kif26a	kinesin family member 26A	1818	0.26
chr19_7069218_7069544	0.29	Macrod1	mono-ADP ribosylhydrolase 1	12571	0.1
chr9_27001001_27001320	0.29	Thyn1	thymocyte nuclear protein 1	1432	0.26
chr11_120231879_120233008	0.29	Bahcc1	BAH domain and coiled-coil containing 1	504	0.52
chr7_68369791_68370269	0.29	Gm44889	predicted gene 44889	14749	0.12
chr5_35388341_35389287	0.29	Hmx1	H6 homeobox 1	294	0.51
chr12_72941105_72942093	0.29	4930447C04Rik	RIKEN cDNA 4930447C04 gene	825	0.49
chr9_69669605_69671558	0.29	Gm47203	predicted gene, 47203	70827	0.09
chr1_194208152_194208457	0.28	4930503O07Rik	RIKEN cDNA 4930503O07 gene	14455	0.3
chr17_29794989_29795742	0.28	Gm50016	predicted gene, 50016	24022	0.14
chr8_120617013_120617164	0.28	1190005I06Rik	RIKEN cDNA 1190005I06 gene	17275	0.08
chrX_134405492_134405850	0.28	Drp2	dystrophin related protein 2	869	0.59
chr11_116515408_116515996	0.28	Rpl36-ps1	ribosomal protein L36, pseudogene 1	11166	0.09
chr14_55833919_55834070	0.28	Nfatc4	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4	3725	0.11
chr7_144285786_144285937	0.28	Shank2	SH3 and multiple ankyrin repeat domains 2	1316	0.55
chr2_119196463_119196630	0.28	Gm14138	predicted gene 14138	9029	0.09
chr5_75158634_75158785	0.28	Pdgfra	platelet derived growth factor receptor, alpha polypeptide	1876	0.2
chr11_88584739_88584890	0.27	Msi2	musashi RNA-binding protein 2	5333	0.28
chr11_83300807_83300958	0.27	Ap2b1	adaptor-related protein complex 2, beta 1 subunit	1601	0.18
chr6_52231944_52233433	0.27	Hoxa10	homeobox A10	636	0.35
chr3_154332843_154334222	0.27	AI606473	expressed sequence AI606473	1535	0.39
chr10_81642066_81642286	0.27	Ankrd24	ankyrin repeat domain 24	1232	0.25
chr2_30399608_30399851	0.27	Dolpp1	dolichyl pyrophosphate phosphatase 1	2308	0.15
chr6_6878154_6880927	0.27	Dlx5	distal-less homeobox 5	2528	0.19
chr6_30169273_30169444	0.27	Mir96	microRNA 96	193	0.69
chr1_128804042_128804193	0.27	Gm26686	predicted gene, 26686	29696	0.19
chr7_45685544_45685874	0.27	Ntn5	netrin 5	1280	0.18
chr17_35926318_35926661	0.27	Ppp1r10	protein phosphatase 1, regulatory subunit 10	5	0.92
chr7_45076239_45076453	0.27	Nosip	nitric oxide synthase interacting protein	62	0.9
chr7_45075409_45075560	0.27	Nosip	nitric oxide synthase interacting protein	227	0.76
chr17_85679503_85681370	0.27	Six2	sine oculis-related homeobox 2	7818	0.18
chr6_90809120_90810568	0.27	Iqsec1	IQ motif and Sec7 domain 1	279	0.89
chr6_72273431_72273622	0.26	Sftpb	surfactant associated protein B	31084	0.11
chr4_154945283_154945859	0.26	Hes5	hes family bHLH transcription factor 5	15352	0.1
chr4_13744037_13744679	0.26	Runx1t1	RUNX1 translocation partner 1	922	0.71
chr17_85072509_85072660	0.26	Prepl	prolyl endopeptidase-like	4890	0.21
chr7_46011295_46011446	0.26	Abcc6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	10301	0.11
chr6_6855562_6856705	0.26	Gm44094	predicted gene, 44094	118	0.94
chr9_65140865_65142286	0.26	Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	363	0.83
chr4_48586042_48586294	0.26	Tmeff1	transmembrane protein with EGF-like and two follistatin-like domains 1	617	0.75
chr2_26314203_26314732	0.26	Gpsm1	G-protein signalling modulator 1 (AGS3-like, C. elegans)	1048	0.36
chr7_35214427_35215048	0.26	Lrp3	low density lipoprotein receptor-related protein 3	555	0.64
chr2_180506623_180506842	0.25	Ntsr1	neurotensin receptor 1	6505	0.17
chr1_78189316_78190249	0.25	Pax3	paired box 3	7056	0.24
chr4_136649051_136649935	0.25	Gm37583	predicted gene, 37583	9911	0.12
chr1_183141874_183142088	0.25	Disp1	dispatched RND transporter family member 1	5480	0.24
chr1_132291328_132291479	0.25	Gm7241	predicted pseudogene 7241	6950	0.12
chr5_34326506_34326657	0.25	Gm43458	predicted gene 43458	949	0.43
chr10_80192077_80192401	0.25	Efna2	ephrin A2	12757	0.08
chr7_34653043_34653418	0.25	Gm12781	predicted gene 12781	46	0.53
chr5_136881600_136883223	0.25	Col26a1	collagen, type XXVI, alpha 1	332	0.82
chr2_26634327_26634478	0.25	Dipk1b	divergent protein kinase domain 1B	199	0.87
chr18_54978491_54979564	0.25	Zfp608	zinc finger protein 608	11139	0.2
chr10_81324031_81324182	0.25	Cactin	cactin, spliceosome C complex subunit	604	0.42
chr11_84725103_84725307	0.25	1700109G15Rik	RIKEN cDNA 1700109G15 gene	4773	0.23
chr7_24607911_24608062	0.25	Phldb3	pleckstrin homology like domain, family B, member 3	2777	0.12
chr3_116421092_116421666	0.25	Cdc14a	CDC14 cell division cycle 14A	1270	0.39
chr8_119792153_119792331	0.25	Meak7	MTOR associated protein , eak-7 homolog	13826	0.16
chr11_102264393_102264544	0.25	Hrob	homologous recombination factor with OB-fold	2504	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2e

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.2	0.5	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1	0.3	GO:0070889	platelet alpha granule organization(GO:0070889)
0.1	0.3	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.1	0.4	GO:0014826	vein smooth muscle contraction(GO:0014826)
0.1	0.4	GO:0060594	mammary gland specification(GO:0060594)
0.1	0.4	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.1	0.2	GO:0097623	potassium ion export across plasma membrane(GO:0097623)
0.1	0.2	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.1	0.2	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.1	0.2	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902)
0.1	0.1	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.1	0.2	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.1	0.1	GO:0038086	VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.1	0.3	GO:0006551	leucine metabolic process(GO:0006551)
0.1	0.2	GO:0045218	zonula adherens maintenance(GO:0045218)
0.1	0.1	GO:0072194	kidney smooth muscle tissue development(GO:0072194)
0.1	0.2	GO:1901256	macrophage colony-stimulating factor production(GO:0036301) granulocyte colony-stimulating factor production(GO:0071611) regulation of granulocyte colony-stimulating factor production(GO:0071655) regulation of macrophage colony-stimulating factor production(GO:1901256)
0.1	0.1	GO:0060447	bud outgrowth involved in lung branching(GO:0060447)
0.1	0.6	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.1	0.2	GO:0010643	cell communication by chemical coupling(GO:0010643)
0.1	0.2	GO:0089700	protein kinase D signaling(GO:0089700)
0.1	0.5	GO:0002091	negative regulation of receptor internalization(GO:0002091)
0.1	0.2	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.1	0.2	GO:0030167	proteoglycan catabolic process(GO:0030167)
0.1	0.2	GO:0046985	positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.1	0.2	GO:0097168	mesenchymal stem cell proliferation(GO:0097168)
0.1	0.2	GO:0015746	tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.1	0.2	GO:2001055	positive regulation of mesenchymal cell apoptotic process(GO:2001055)
0.1	0.3	GO:0044828	negative regulation by host of viral genome replication(GO:0044828)
0.0	0.2	GO:0060592	mammary gland formation(GO:0060592)
0.0	0.5	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.3	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.2	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0071336	regulation of hair follicle cell proliferation(GO:0071336)
0.0	0.1	GO:0014707	branchiomeric skeletal muscle development(GO:0014707)
0.0	0.1	GO:0090027	negative regulation of monocyte chemotaxis(GO:0090027)
0.0	0.2	GO:0051122	hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0	0.1	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.4	GO:0051001	negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0	0.1	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.1	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0	0.1	GO:0051105	regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.0	0.2	GO:0097500	receptor localization to nonmotile primary cilium(GO:0097500)
0.0	0.2	GO:1903977	positive regulation of glial cell migration(GO:1903977)
0.0	0.4	GO:0007210	serotonin receptor signaling pathway(GO:0007210)
0.0	0.1	GO:0046439	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:0003419	growth plate cartilage chondrocyte proliferation(GO:0003419)
0.0	0.1	GO:0002930	trabecular meshwork development(GO:0002930)
0.0	0.1	GO:0061055	myotome development(GO:0061055)
0.0	0.4	GO:0047497	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0	0.1	GO:0098700	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0	0.1	GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0	0.0	GO:0072197	ureter morphogenesis(GO:0072197)
0.0	0.0	GO:0021590	cerebellum maturation(GO:0021590)
0.0	0.1	GO:0007223	Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0	0.1	GO:0033092	positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0	0.1	GO:0035990	tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.0	0.2	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.1	GO:0019853	L-ascorbic acid biosynthetic process(GO:0019853)
0.0	0.2	GO:0070314	G1 to G0 transition(GO:0070314)
0.0	0.1	GO:0045041	protein import into mitochondrial intermembrane space(GO:0045041)
0.0	0.1	GO:0030421	defecation(GO:0030421)
0.0	0.2	GO:0033504	floor plate development(GO:0033504)
0.0	0.1	GO:0014816	skeletal muscle satellite cell differentiation(GO:0014816)
0.0	0.2	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0	0.3	GO:0031507	heterochromatin assembly(GO:0031507)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.2	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.2	GO:0006012	galactose metabolic process(GO:0006012)
0.0	0.1	GO:0071673	positive regulation of smooth muscle cell chemotaxis(GO:0071673)
0.0	0.0	GO:1901727	positive regulation of histone deacetylase activity(GO:1901727)
0.0	0.4	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0	0.1	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.0	0.1	GO:0015888	thiamine transport(GO:0015888)
0.0	0.1	GO:0033686	positive regulation of luteinizing hormone secretion(GO:0033686)
0.0	0.1	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.1	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.1	GO:0042414	epinephrine metabolic process(GO:0042414)
0.0	0.1	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.1	GO:0060075	regulation of resting membrane potential(GO:0060075)
0.0	0.1	GO:0070162	adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163)
0.0	0.1	GO:0009732	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.1	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.3	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0	0.1	GO:0072318	clathrin coat disassembly(GO:0072318)
0.0	0.1	GO:0002678	positive regulation of chronic inflammatory response(GO:0002678)
0.0	0.1	GO:0072718	response to cisplatin(GO:0072718)
0.0	0.1	GO:2000974	negative regulation of pro-B cell differentiation(GO:2000974)
0.0	0.2	GO:1901841	regulation of high voltage-gated calcium channel activity(GO:1901841)
0.0	0.0	GO:0072240	distal convoluted tubule development(GO:0072025) DCT cell differentiation(GO:0072069) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) metanephric DCT cell differentiation(GO:0072240)
0.0	0.1	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.1	GO:0021557	oculomotor nerve development(GO:0021557)
0.0	0.8	GO:0035136	forelimb morphogenesis(GO:0035136)
0.0	0.1	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.1	GO:0042435	indole-containing compound biosynthetic process(GO:0042435)
0.0	0.0	GO:0046533	negative regulation of photoreceptor cell differentiation(GO:0046533)
0.0	0.1	GO:0060696	regulation of phospholipid catabolic process(GO:0060696)
0.0	0.1	GO:0060155	platelet dense granule organization(GO:0060155)
0.0	0.1	GO:0033861	negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.0	0.2	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.0	GO:0060167	regulation of adenosine receptor signaling pathway(GO:0060167)
0.0	0.1	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.0	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.0	0.0	GO:0010535	positive regulation of activation of JAK2 kinase activity(GO:0010535)
0.0	0.0	GO:2000054	regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0	0.0	GO:0046532	regulation of photoreceptor cell differentiation(GO:0046532)
0.0	0.1	GO:1902661	regulation of glucose mediated signaling pathway(GO:1902659) positive regulation of glucose mediated signaling pathway(GO:1902661)
0.0	0.3	GO:0009992	cellular water homeostasis(GO:0009992)
0.0	0.2	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.1	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.0	GO:0061626	pharyngeal arch artery morphogenesis(GO:0061626)
0.0	0.0	GO:1990123	L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
0.0	0.1	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0	0.1	GO:0006742	NADP catabolic process(GO:0006742)
0.0	0.2	GO:0071625	vocalization behavior(GO:0071625)
0.0	0.1	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.1	GO:0071798	response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0	0.1	GO:0061043	regulation of vascular wound healing(GO:0061043)
0.0	0.2	GO:0061430	bone trabecula morphogenesis(GO:0061430)
0.0	0.1	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.1	GO:0060339	negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0	0.0	GO:0070350	white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.0	0.2	GO:0021859	pyramidal neuron differentiation(GO:0021859)
0.0	0.1	GO:0072553	terminal button organization(GO:0072553)
0.0	0.1	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.1	GO:2000543	positive regulation of gastrulation(GO:2000543)
0.0	0.1	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.5	GO:0030865	cortical cytoskeleton organization(GO:0030865)
0.0	0.1	GO:1904948	midbrain dopaminergic neuron differentiation(GO:1904948)
0.0	0.1	GO:0048703	embryonic viscerocranium morphogenesis(GO:0048703)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0051256	mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.0	0.1	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.1	GO:0061002	negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0	0.1	GO:1904252	negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0	0.2	GO:0046549	retinal cone cell development(GO:0046549)
0.0	0.0	GO:0046061	dATP catabolic process(GO:0046061)
0.0	0.2	GO:0035116	embryonic hindlimb morphogenesis(GO:0035116)
0.0	0.1	GO:1903423	positive regulation of synaptic vesicle recycling(GO:1903423)
0.0	0.1	GO:0060166	olfactory pit development(GO:0060166)
0.0	0.1	GO:0042663	regulation of endodermal cell fate specification(GO:0042663)
0.0	0.1	GO:0060084	synaptic transmission involved in micturition(GO:0060084)
0.0	0.1	GO:0097503	sialylation(GO:0097503)
0.0	0.1	GO:0046013	regulation of T cell homeostatic proliferation(GO:0046013)
0.0	0.0	GO:0030997	regulation of centriole-centriole cohesion(GO:0030997)
0.0	0.0	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.0	GO:0003097	renal water transport(GO:0003097)
0.0	0.0	GO:0010182	carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255)
0.0	0.0	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.0	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.1	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0	0.0	GO:0018364	peptidyl-glutamine methylation(GO:0018364)
0.0	0.2	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0	0.0	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0090306	spindle assembly involved in meiosis(GO:0090306)
0.0	0.0	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:1903297	regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.0	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.1	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0	0.0	GO:0006868	glutamine transport(GO:0006868)
0.0	0.0	GO:1905216	positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0	0.0	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.0	GO:0043096	purine nucleobase salvage(GO:0043096)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.0	GO:0060623	regulation of chromosome condensation(GO:0060623)
0.0	0.1	GO:0097152	mesenchymal cell apoptotic process(GO:0097152) regulation of mesenchymal cell apoptotic process(GO:2001053) negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0	0.0	GO:0070827	chromatin maintenance(GO:0070827)
0.0	0.1	GO:0003190	atrioventricular valve formation(GO:0003190)
0.0	0.1	GO:0043137	DNA replication, removal of RNA primer(GO:0043137)
0.0	0.4	GO:0010824	regulation of centrosome duplication(GO:0010824)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0071681	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0	0.1	GO:0060065	uterus development(GO:0060065)
0.0	0.2	GO:0031163	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.0	GO:0002018	renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0	0.0	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.2	GO:0071786	endoplasmic reticulum tubular network organization(GO:0071786)
0.0	0.0	GO:0042374	phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.2	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.1	GO:0042373	vitamin K metabolic process(GO:0042373)
0.0	0.0	GO:0030917	midbrain-hindbrain boundary development(GO:0030917)
0.0	0.0	GO:0060460	left lung development(GO:0060459) left lung morphogenesis(GO:0060460)
0.0	0.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.0	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0	0.0	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.0	GO:0060948	cardiac vascular smooth muscle cell development(GO:0060948)
0.0	0.1	GO:0097151	positive regulation of inhibitory postsynaptic potential(GO:0097151)
0.0	0.0	GO:0035093	spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0	0.0	GO:0035513	oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.3	GO:0060612	adipose tissue development(GO:0060612)
0.0	0.0	GO:0014053	negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.0	0.0	GO:1903818	positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0	0.0	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.0	0.0	GO:0015884	folic acid transport(GO:0015884)
0.0	0.1	GO:0006415	translational termination(GO:0006415)
0.0	0.1	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.1	GO:0070831	basement membrane assembly(GO:0070831)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0033129	positive regulation of histone phosphorylation(GO:0033129)
0.0	0.0	GO:0034633	retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.0	0.2	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.0	0.1	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.0	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.1	GO:2000270	negative regulation of fibroblast apoptotic process(GO:2000270)
0.0	0.0	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.0	GO:0000189	MAPK import into nucleus(GO:0000189)
0.0	0.0	GO:0071504	response to heparin(GO:0071503) cellular response to heparin(GO:0071504)
0.0	0.0	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.1	GO:0034969	histone arginine methylation(GO:0034969)
0.0	0.0	GO:0019747	regulation of isoprenoid metabolic process(GO:0019747)
0.0	0.1	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0	0.1	GO:0042256	mature ribosome assembly(GO:0042256)
0.0	0.1	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.0	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.0	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.0	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.6	GO:0060021	palate development(GO:0060021)
0.0	0.0	GO:0003219	cardiac right ventricle formation(GO:0003219)
0.0	0.0	GO:0046098	guanine metabolic process(GO:0046098)
0.0	0.1	GO:0097320	membrane tubulation(GO:0097320)
0.0	0.0	GO:0021773	striatal medium spiny neuron differentiation(GO:0021773)
0.0	0.0	GO:0071316	cellular response to nicotine(GO:0071316)
0.0	0.0	GO:0061197	fungiform papilla morphogenesis(GO:0061197)
0.0	0.0	GO:1901838	positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0	0.1	GO:0075525	viral translational termination-reinitiation(GO:0075525)
0.0	0.0	GO:0044375	regulation of peroxisome size(GO:0044375)
0.0	0.0	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.3	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.3	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.2	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.3	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	0.2	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0005745	m-AAA complex(GO:0005745)
0.0	0.3	GO:0034709	methylosome(GO:0034709)
0.0	0.2	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	0.1	GO:0072534	perineuronal net(GO:0072534)
0.0	0.3	GO:0043196	varicosity(GO:0043196)
0.0	0.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.2	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0001674	female germ cell nucleus(GO:0001674)
0.0	0.2	GO:0001650	fibrillar center(GO:0001650)
0.0	0.2	GO:0036156	inner dynein arm(GO:0036156)
0.0	0.1	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.1	GO:0034991	nuclear meiotic cohesin complex(GO:0034991)
0.0	0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0044308	axonal spine(GO:0044308)
0.0	0.2	GO:0060091	kinocilium(GO:0060091)
0.0	0.1	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.0	0.2	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.4	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.1	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.0	GO:0097513	myosin II filament(GO:0097513)
0.0	0.1	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0	0.1	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0	0.0	GO:0032280	symmetric synapse(GO:0032280)
0.0	0.1	GO:0043194	axon initial segment(GO:0043194)
0.0	0.0	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.1	GO:0005642	annulate lamellae(GO:0005642)
0.0	0.0	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.0	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.1	GO:0032983	kainate selective glutamate receptor complex(GO:0032983)
0.0	0.0	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.0	0.0	GO:0044354	pinosome(GO:0044352) macropinosome(GO:0044354)
0.0	0.8	GO:0034705	potassium channel complex(GO:0034705)
0.0	0.2	GO:0001741	XY body(GO:0001741)
0.0	0.2	GO:0090568	nuclear transcriptional repressor complex(GO:0090568)
0.0	0.3	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.1	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.1	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	0.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.0	GO:1990393	3M complex(GO:1990393)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.1	0.4	GO:0031708	endothelin B receptor binding(GO:0031708)
0.1	0.3	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1	0.3	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1	0.2	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.1	0.2	GO:0030519	snoRNP binding(GO:0030519)
0.1	0.2	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.1	0.2	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.1	0.2	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.2	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.2	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.2	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0036033	mediator complex binding(GO:0036033)
0.0	0.3	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0071253	connexin binding(GO:0071253)
0.0	0.3	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0	0.2	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.2	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.0	0.3	GO:0015254	glycerol transmembrane transporter activity(GO:0015168) glycerol channel activity(GO:0015254)
0.0	0.1	GO:0004396	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.0	0.2	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.2	GO:0039706	co-receptor binding(GO:0039706)
0.0	0.4	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0003747	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.1	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.0	0.1	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.0	0.2	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.0	0.1	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0	0.1	GO:0046624	sphingolipid transporter activity(GO:0046624)
0.0	0.1	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.0	0.9	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.1	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0	0.1	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.0	0.4	GO:0031489	myosin V binding(GO:0031489)
0.0	0.1	GO:0030619	U1 snRNA binding(GO:0030619)
0.0	0.1	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.4	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.1	GO:0031127	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.1	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.0	0.1	GO:0031802	type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.3	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.2	GO:0001164	RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0	0.1	GO:1990254	keratin filament binding(GO:1990254)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0051870	methotrexate binding(GO:0051870)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0008240	tripeptidyl-peptidase activity(GO:0008240)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.0	0.4	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.0	GO:0015087	cobalt ion transmembrane transporter activity(GO:0015087)
0.0	0.1	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.0	0.4	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0052759	4-methyloctanoyl-CoA dehydrogenase activity(GO:0034580) naphthyl-2-methyl-succinyl-CoA dehydrogenase activity(GO:0034845) 2-methylhexanoyl-CoA dehydrogenase activity(GO:0034916) propionyl-CoA dehydrogenase activity(GO:0043820) thiol-driven fumarate reductase activity(GO:0043830) coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity(GO:0052758) coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity(GO:0052759) coenzyme F420-dependent 2,4-dinitrophenol reductase activity(GO:0052760)
0.0	0.3	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.2	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.4	GO:0008483	transaminase activity(GO:0008483)
0.0	0.0	GO:0070698	type I activin receptor binding(GO:0070698)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.0	0.4	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.0	GO:0019002	GMP binding(GO:0019002)
0.0	0.0	GO:0042731	PH domain binding(GO:0042731)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.2	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.1	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.3	GO:0071837	HMG box domain binding(GO:0071837)
0.0	0.2	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.0	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.0	GO:0035514	DNA demethylase activity(GO:0035514)
0.0	0.0	GO:0047276	N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.0	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.0	0.0	GO:0035515	oxidative RNA demethylase activity(GO:0035515)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.0	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	0.0	GO:0004470	malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471)
0.0	0.0	GO:0035851	Krueppel-associated box domain binding(GO:0035851)
0.0	0.0	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.0	GO:0008948	oxaloacetate decarboxylase activity(GO:0008948)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.0	0.0	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.1	GO:1990446	U1 snRNP binding(GO:1990446)
0.0	0.0	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0	0.2	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.1	GO:0001054	RNA polymerase I activity(GO:0001054)
0.0	0.0	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.0	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.0	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.0	0.1	GO:0033265	choline binding(GO:0033265)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.7	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.2	ST STAT3 PATHWAY	STAT3 Pathway
0.0	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.0	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.8	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.8	NABA COLLAGENS	Genes encoding collagen proteins
0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.1	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.5	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.5	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.3	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.5	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.3	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.3	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.3	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.3	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.3	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.2	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.2	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.8	REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.2	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.2	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.3	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.0	REACTOME G PROTEIN BETA GAMMA SIGNALLING	Genes involved in G-protein beta:gamma signalling
0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.2	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.2	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor

Results for Tfap2e

Z-value: 0.71

Motif logo

Transcription factors associated with Tfap2e

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Tfap2e motif across conditions

Conditions sorted by the z-value of the Tfap2e motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2e

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: