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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Thrb

Z-value: 0.62

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Transcription factors associated with Thrb

Gene Symbol	Gene ID	Gene Info
Thrb Ensembl NCBI MGI UniProt	ENSMUSG00000021779.10	Thrb

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Thrb	chr14_17659232_17659747	772	0.780111	0.32	1.3e-02	Click!
Thrb	chr14_17632749_17633318	27228	0.255791	0.24	6.9e-02	Click!
Thrb	chr14_17660912_17661470	295	0.947354	0.21	1.1e-01	Click!
Thrb	chr14_17660241_17660826	1	0.988506	0.20	1.2e-01	Click!
Thrb	chr14_17479068_17479220	181117	0.031897	0.09	4.9e-01	Click!

Activity of the Thrb motif across conditions

Conditions sorted by the z-value of the Thrb motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_98245804_98245958	1.25	Gm42821	predicted gene 42821	2718	0.21
chr13_49610100_49610769	1.25	Ogn	osteoglycin	2388	0.21
chr1_155146107_155146796	1.18	Mr1	major histocompatibility complex, class I-related	332	0.85
chr10_56468695_56469687	1.14	Gm9118	predicted gene 9118	28150	0.16
chr19_47319497_47320713	1.06	Sh3pxd2a	SH3 and PX domains 2A	5354	0.2
chr9_110380536_110381006	1.04	Scap	SREBF chaperone	2478	0.17
chr15_27786588_27788615	1.02	Trio	triple functional domain (PTPRF interacting)	1037	0.6
chr11_3809703_3809854	0.99	Gm24013	predicted gene, 24013	20886	0.13
chr9_64017614_64019400	0.93	Smad6	SMAD family member 6	1520	0.33
chr11_90030594_90032253	0.93	Tmem100	transmembrane protein 100	1075	0.58
chr16_34923616_34923830	0.90	Mylk	myosin, light polypeptide kinase	6619	0.2
chr16_4439334_4439485	0.85	Adcy9	adenylate cyclase 9	18911	0.19
chr3_122104159_122104612	0.83	Abca4	ATP-binding cassette, sub-family A (ABC1), member 4	15655	0.16
chr15_101128362_101129824	0.83	Acvrl1	activin A receptor, type II-like 1	169	0.91
chr1_166126774_166128045	0.82	Dusp27	dual specificity phosphatase 27 (putative)	487	0.76
chr7_100288260_100289308	0.81	P4ha3	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III	3242	0.18
chr12_86000637_86000811	0.80	Gm26531	predicted gene, 26531	21703	0.16
chr6_71261026_71261496	0.77	Smyd1	SET and MYND domain containing 1	971	0.38
chr19_38042662_38044080	0.74	Myof	myoferlin	13	0.97
chr9_118608620_118608968	0.74	Itga9	integrin alpha 9	2104	0.28
chr10_56379554_56379705	0.72	Gja1	gap junction protein, alpha 1	541	0.79
chr2_163396823_163398215	0.72	Jph2	junctophilin 2	430	0.77
chr11_94498570_94500249	0.72	Epn3	epsin 3	289	0.85
chr15_76194294_76195998	0.71	Plec	plectin	564	0.56
chr15_100401682_100401947	0.71	Slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	1429	0.28
chr6_99095299_99096526	0.71	Foxp1	forkhead box P1	293	0.93
chr3_107985653_107986442	0.70	Gstm2	glutathione S-transferase, mu 2	313	0.73
chr12_76071969_76072878	0.70	Syne2	spectrin repeat containing, nuclear envelope 2	407	0.88
chr1_71421789_71421940	0.68	Abca12	ATP-binding cassette, sub-family A (ABC1), member 12	6954	0.28
chr16_4521657_4521808	0.68	Srl	sarcalumenin	1331	0.38
chr17_49562101_49562252	0.68	Daam2	dishevelled associated activator of morphogenesis 2	2130	0.39
chr19_43387895_43388797	0.68	Hpse2	heparanase 2	9	0.98
chr2_118112796_118113528	0.67	Thbs1	thrombospondin 1	1286	0.33
chr5_124951228_124951428	0.66	Rflna	refilin A	51893	0.11
chr3_51378444_51378901	0.66	Gm5103	predicted gene 5103	596	0.57
chr1_185092269_185092420	0.66	Gm37662	predicted gene, 37662	353	0.85
chr1_45501357_45501527	0.65	Col5a2	collagen, type V, alpha 2	1840	0.29
chr19_57417994_57418728	0.64	Gm50271	predicted gene, 50271	5133	0.19
chr2_164442047_164443132	0.64	Sdc4	syndecan 4	597	0.53
chr2_60672831_60673749	0.61	Itgb6	integrin beta 6	403	0.88
chr2_127990589_127990740	0.60	Acoxl	acyl-Coenzyme A oxidase-like	81606	0.08
chr7_112155826_112156308	0.59	Dkk3	dickkopf WNT signaling pathway inhibitor 3	2990	0.34
chr15_79516155_79517393	0.58	Kdelr3	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3	363	0.76
chr10_107930315_107930872	0.58	Gm29685	predicted gene, 29685	16052	0.22
chr17_79287021_79288072	0.57	Gm5230	predicted gene 5230	29497	0.19
chr19_34551724_34552072	0.57	Ifit2	interferon-induced protein with tetratricopeptide repeats 2	1188	0.33
chr16_43701967_43702307	0.56	Gm49735	predicted gene, 49735	8695	0.16
chrX_142826741_142826976	0.55	Tmem164	transmembrane protein 164	1117	0.58
chr3_95673620_95674691	0.55	Adamtsl4	ADAMTS-like 4	2996	0.14
chr1_28856567_28856718	0.55	Gm5697	predicted gene 5697	53921	0.15
chr5_135486772_135486923	0.55	Hip1	huntingtin interacting protein 1	2411	0.23
chr6_17305946_17307996	0.54	Cav1	caveolin 1, caveolae protein	77	0.97
chr15_102102931_102104191	0.53	Tns2	tensin 2	573	0.62
chr10_34485029_34485207	0.53	Frk	fyn-related kinase	1586	0.46
chr7_130258773_130259779	0.53	Fgfr2	fibroblast growth factor receptor 2	2581	0.38
chr15_76205535_76206787	0.53	Plec	plectin	160	0.89
chr3_104565801_104565952	0.52	Gm26091	predicted gene, 26091	35363	0.09
chr16_29560429_29560777	0.52	Atp13a4	ATPase type 13A4	15739	0.2
chr11_86586191_86587628	0.52	Vmp1	vacuole membrane protein 1	28	0.97
chr14_101532225_101532447	0.52	Tbc1d4	TBC1 domain family, member 4	25010	0.19
chr3_27904926_27905081	0.52	Tmem212	transmembrane protein 212	8635	0.22
chr2_33975957_33976172	0.51	Gm13404	predicted gene 13404	2182	0.35
chr13_12098517_12098668	0.50	Ryr2	ryanodine receptor 2, cardiac	7867	0.2
chr4_139460214_139460365	0.50	Ubr4	ubiquitin protein ligase E3 component n-recognin 4	2970	0.25
chr2_33219879_33220609	0.50	Angptl2	angiopoietin-like 2	4127	0.19
chr9_110875577_110875744	0.50	Tmie	transmembrane inner ear	361	0.73
chr15_77343031_77343868	0.50	Gm49436	predicted gene, 49436	23250	0.11
chr11_102989753_102990660	0.50	Dcakd	dephospho-CoA kinase domain containing	7342	0.12
chr18_11058575_11059292	0.50	Gata6	GATA binding protein 6	114	0.97
chr18_12270079_12270307	0.50	Ankrd29	ankyrin repeat domain 29	1504	0.35
chr9_44485094_44485975	0.50	Bcl9l	B cell CLL/lymphoma 9-like	1713	0.13
chr18_80360572_80360723	0.49	D330025C20Rik	RIKEN cDNA D330025C20 gene	2134	0.23
chr4_147969208_147969498	0.49	Nppb	natriuretic peptide type B	16435	0.09
chr5_119836883_119837654	0.48	Tbx5	T-box 5	1113	0.47
chr6_115990945_115992684	0.48	Plxnd1	plexin D1	3191	0.2
chr13_31627499_31628464	0.48	Gm27516	predicted gene, 27516	1438	0.26
chr7_49528137_49528903	0.48	Nav2	neuron navigator 2	19672	0.23
chr17_56162523_56163227	0.47	Tnfaip8l1	tumor necrosis factor, alpha-induced protein 8-like 1	398	0.71
chrX_99459091_99459649	0.47	Gm14808	predicted gene 14808	345	0.87
chr14_26041922_26042457	0.47	Gm9780	predicted gene 9780	485	0.69
chr17_47178960_47179764	0.47	Trerf1	transcriptional regulating factor 1	33025	0.17
chr3_87951379_87952516	0.46	Crabp2	cellular retinoic acid binding protein II	197	0.87
chr15_91971921_91972104	0.46	Gm18979	predicted gene, 18979	11272	0.22
chr17_28345051_28346589	0.46	Tead3	TEA domain family member 3	4526	0.11
chr9_123480120_123480887	0.46	Limd1	LIM domains containing 1	107	0.97
chr10_77685958_77687018	0.46	Tspear	thrombospondin type laminin G domain and EAR repeats	81	0.9
chr10_81195163_81195734	0.46	Atcayos	ataxia, cerebellar, Cayman type, opposite strand	757	0.35
chr14_25902144_25902650	0.45	Plac9a	placenta specific 9a	77	0.96
chr4_140580764_140581885	0.45	Arhgef10l	Rho guanine nucleotide exchange factor (GEF) 10-like	478	0.83
chr8_124775682_124775942	0.45	Gm45856	predicted gene 45856	5921	0.12
chr14_54975812_54976152	0.44	Mir208b	microRNA 208b	206	0.75
chr16_38361999_38362192	0.44	Popdc2	popeye domain containing 2	114	0.94
chr5_92901808_92902019	0.44	Shroom3	shroom family member 3	3920	0.27
chr19_56356629_56356975	0.44	Gm17197	predicted gene 17197	7460	0.18
chr15_38197898_38198049	0.44	Gm35167	predicted gene, 35167	4244	0.16
chr10_18197014_18197461	0.44	Ect2l	epithelial cell transforming sequence 2 oncogene-like	4116	0.21
chr14_118506460_118506954	0.44	Abcc4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	23258	0.17
chr5_66497840_66498108	0.43	Apbb2	amyloid beta (A4) precursor protein-binding, family B, member 2	5802	0.17
chr4_130014339_130014490	0.43	Adgrb2	adhesion G protein-coupled receptor B2	778	0.56
chr7_45102549_45104045	0.43	Fcgrt	Fc receptor, IgG, alpha chain transporter	211	0.75
chr8_26384770_26384921	0.43	Gm31898	predicted gene, 31898	50868	0.1
chr16_31878792_31879568	0.43	Meltf	melanotransferrin	370	0.79
chr7_25802106_25803222	0.42	Gm45226	predicted gene 45226	7511	0.08
chr7_130060387_130060669	0.41	Gm23847	predicted gene, 23847	25434	0.23
chr14_26181467_26182596	0.41	Plac9b	placenta specific 9b	175	0.92
chr11_95259399_95259633	0.41	Tac4	tachykinin 4	2013	0.24
chr4_109550484_109550898	0.40	Gm22497	predicted gene, 22497	13652	0.15
chr12_86075117_86075268	0.40	Gm48008	predicted gene, 48008	3452	0.17
chrX_160502969_160503207	0.40	Phka2	phosphorylase kinase alpha 2	623	0.7
chr2_33714996_33715766	0.40	9430024E24Rik	RIKEN cDNA 9430024E24 gene	3518	0.24
chr18_66344941_66345611	0.39	Ccbe1	collagen and calcium binding EGF domains 1	42535	0.1
chr6_86792679_86793848	0.39	Anxa4	annexin A4	301	0.87
chr10_26774495_26774696	0.39	Arhgap18	Rho GTPase activating protein 18	2048	0.32
chr12_56533030_56535358	0.39	Nkx2-1	NK2 homeobox 1	912	0.36
chr11_33145103_33146186	0.39	Fgf18	fibroblast growth factor 18	1151	0.43
chr9_62420746_62421699	0.39	Coro2b	coronin, actin binding protein, 2B	6779	0.24
chr19_44719535_44720602	0.39	Gm35610	predicted gene, 35610	19811	0.13
chr4_31823845_31825033	0.38	Map3k7	mitogen-activated protein kinase kinase kinase 7	139658	0.05
chr13_55830047_55831334	0.38	Pitx1	paired-like homeodomain transcription factor 1	735	0.57
chr14_26449969_26450211	0.38	Slmap	sarcolemma associated protein	7200	0.16
chr12_84875703_84876939	0.38	Ltbp2	latent transforming growth factor beta binding protein 2	158	0.82
chr5_66069344_66070452	0.38	Gm43775	predicted gene 43775	2997	0.17
chr16_85150827_85151226	0.38	Gm49226	predicted gene, 49226	2197	0.3
chr9_108228044_108228195	0.38	Dag1	dystroglycan 1	35590	0.07
chr3_67373789_67374948	0.38	Mlf1	myeloid leukemia factor 1	220	0.85
chr17_68165450_68165981	0.38	Gm49944	predicted gene, 49944	7841	0.22
chr9_95693924_95694752	0.37	Pcolce2	procollagen C-endopeptidase enhancer 2	14032	0.13
chr10_103027884_103029519	0.37	Alx1	ALX homeobox 1	74	0.97
chr17_44137199_44137398	0.37	Clic5	chloride intracellular channel 5	2530	0.33
chr1_152304992_152305188	0.37	Gm38238	predicted gene, 38238	12562	0.24
chr8_84200619_84201949	0.37	Gm37352	predicted gene, 37352	415	0.58
chr11_68390483_68390938	0.37	Ntn1	netrin 1	3698	0.27
chr12_111920312_111920463	0.37	Gm3565	predicted gene 3565	10650	0.11
chr4_138756785_138756962	0.37	Pla2g2f	phospholipase A2, group IIF	753	0.56
chr15_74733696_74733847	0.37	Lypd2	Ly6/Plaur domain containing 2	546	0.52
chr9_106371285_106372888	0.37	Dusp7	dual specificity phosphatase 7	1342	0.31
chr5_67669613_67669824	0.37	Atp8a1	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	9684	0.14
chr15_41830961_41831808	0.36	Oxr1	oxidation resistance 1	391	0.87
chr10_66919897_66921448	0.36	Gm26576	predicted gene, 26576	370	0.51
chr2_38196447_38197128	0.36	Gm44455	predicted gene, 44455	28335	0.16
chr4_32936919_32937425	0.36	Ankrd6	ankyrin repeat domain 6	13654	0.15
chr13_31810556_31811961	0.36	Foxc1	forkhead box C1	4625	0.19
chr12_73052052_73054521	0.36	Six1	sine oculis-related homeobox 1	601	0.76
chr13_95719581_95720106	0.36	Gm50469	predicted gene, 50469	12349	0.14
chr3_101835437_101836744	0.36	Mab21l3	mab-21-like 3	133	0.97
chr6_136660962_136662291	0.36	Plbd1	phospholipase B domain containing 1	247	0.91
chr3_138069501_138070764	0.36	1110002E22Rik	RIKEN cDNA 1110002E22 gene	1465	0.3
chr8_123186072_123187147	0.36	Dpep1	dipeptidase 1	367	0.69
chr5_36701464_36701615	0.35	D5Ertd579e	DNA segment, Chr 5, ERATO Doi 579, expressed	5515	0.15
chr1_186703655_186704733	0.35	Tgfb2	transforming growth factor, beta 2	139	0.93
chr11_5971864_5972423	0.35	Camk2b	calcium/calmodulin-dependent protein kinase II, beta	11995	0.13
chr8_87233933_87234270	0.35	Gm27169	predicted gene 27169	31075	0.16
chr2_170879045_170879196	0.35	Gm14263	predicted gene 14263	75704	0.11
chr4_137489689_137489944	0.35	Hspg2	perlecan (heparan sulfate proteoglycan 2)	21013	0.13
chr11_85667588_85668438	0.34	Bcas3	breast carcinoma amplified sequence 3	27309	0.17
chr3_152943448_152943599	0.34	Gm16231	predicted gene 16231	210	0.93
chr5_14028529_14028806	0.34	Gm43519	predicted gene 43519	773	0.63
chr2_30604757_30605755	0.34	Cstad	CSA-conditional, T cell activation-dependent protein	39	0.97
chr10_122963294_122964406	0.34	Mirlet7i	microRNA let7i	21874	0.16
chr18_75382116_75382565	0.33	Smad7	SMAD family member 7	7426	0.22
chr7_69740270_69740768	0.33	Gm7627	predicted gene 7627	133679	0.05
chrX_73929866_73931201	0.33	Renbp	renin binding protein	208	0.88
chr10_84530624_84531496	0.33	Ckap4	cytoskeleton-associated protein 4	2976	0.16
chr11_59223016_59223179	0.33	Arf1	ADP-ribosylation factor 1	5065	0.11
chr11_87443002_87443199	0.33	Rnu3b1	U3B small nuclear RNA 1	137	0.89
chr17_26848242_26848532	0.33	Nkx2-5	NK2 homeobox 5	3378	0.14
chr8_31120852_31121424	0.33	Rnf122	ring finger protein 122	9274	0.15
chr4_5327298_5327481	0.33	Gm11782	predicted gene 11782	223834	0.02
chr6_72597498_72597649	0.33	Elmod3	ELMO/CED-12 domain containing 3	769	0.34
chr17_85691735_85693137	0.32	CJ186046Rik	Riken cDNA CJ186046 gene	1193	0.46
chr7_16823026_16823360	0.32	Strn4	striatin, calmodulin binding protein 4	122	0.93
chr1_15791844_15792059	0.32	Terf1	telomeric repeat binding factor 1	13695	0.16
chr5_145115072_145115244	0.32	Arpc1b	actin related protein 2/3 complex, subunit 1B	842	0.42
chrX_161997301_161997452	0.32	Gm26317	predicted gene, 26317	72081	0.11
chr10_111801109_111801260	0.32	Gm47865	predicted gene, 47865	1331	0.33
chr5_67427677_67428127	0.32	Gm42632	predicted gene 42632	91	0.42
chr1_82586379_82587667	0.32	Col4a3	collagen, type IV, alpha 3	47	0.67
chr8_57799694_57800553	0.32	Galntl6	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	3533	0.27
chr2_71626794_71626945	0.32	Dlx2	distal-less homeobox 2	80115	0.06
chrX_12886648_12887120	0.31	Gm25063	predicted gene, 25063	16522	0.17
chr13_55018577_55018728	0.31	Hk3	hexokinase 3	2252	0.24
chr9_84503048_84503199	0.31	Gm39388	predicted gene, 39388	74837	0.1
chr5_24366542_24366693	0.31	Nos3	nitric oxide synthase 3, endothelial cell	1807	0.18
chr15_74997196_74997485	0.31	Ly6a	lymphocyte antigen 6 complex, locus A	294	0.78
chr1_162076839_162077220	0.31	Gm37767	predicted gene, 37767	11439	0.19
chr7_101377838_101379825	0.31	Arap1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	462	0.71
chr9_53342768_53342919	0.30	Exph5	exophilin 5	1654	0.36
chr12_103336858_103338251	0.30	Gm15523	predicted gene 15523	648	0.43
chr2_38514387_38514655	0.30	Nek6	NIMA (never in mitosis gene a)-related expressed kinase 6	60	0.96
chr14_21903607_21905272	0.30	4931407E12Rik	RIKEN cDNA 4931407E12 gene	14673	0.14
chr17_33778675_33780469	0.30	Angptl4	angiopoietin-like 4	429	0.65
chr17_13683677_13683962	0.30	Gm16046	predicted gene 16046	303	0.87
chr10_12547923_12549201	0.30	Utrn	utrophin	317	0.94
chr1_97802358_97802693	0.30	Pam	peptidylglycine alpha-amidating monooxygenase	23460	0.16
chr9_50751156_50752468	0.30	Cryab	crystallin, alpha B	65	0.86
chr5_143000025_143001100	0.30	Rnf216	ring finger protein 216	16212	0.14
chr2_174288589_174289023	0.30	Gnasas1	GNAS antisense RNA 1	3371	0.16
chr4_76369301_76369461	0.30	Gm11252	predicted gene 11252	23773	0.21
chr10_81195811_81196102	0.30	Atcayos	ataxia, cerebellar, Cayman type, opposite strand	1265	0.19
chr19_5842574_5845856	0.30	Neat1	nuclear paraspeckle assembly transcript 1 (non-protein coding)	1044	0.25

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Thrb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.2	0.7	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.2	0.6	GO:0010643	cell communication by chemical coupling(GO:0010643)
0.2	0.8	GO:0031581	hemidesmosome assembly(GO:0031581)
0.2	0.6	GO:0051891	positive regulation of cardioblast differentiation(GO:0051891)
0.2	0.5	GO:0070458	detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.2	0.5	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1	0.4	GO:0060931	sinoatrial node cell development(GO:0060931)
0.1	0.6	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.1	0.8	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.1	0.2	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.1	0.3	GO:0014873	response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.1	0.3	GO:0060948	cardiac vascular smooth muscle cell development(GO:0060948)
0.1	0.3	GO:0007525	somatic muscle development(GO:0007525)
0.1	0.7	GO:0099515	actin filament-based transport(GO:0099515)
0.1	0.2	GO:2001027	negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1	0.3	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1	0.3	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.1	0.3	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.1	0.7	GO:0001778	plasma membrane repair(GO:0001778)
0.1	0.2	GO:0060486	Clara cell differentiation(GO:0060486)
0.1	0.3	GO:0048625	myoblast fate commitment(GO:0048625)
0.1	0.5	GO:0060842	arterial endothelial cell differentiation(GO:0060842)
0.1	0.3	GO:0035983	response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
0.1	0.4	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.1	0.3	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1	0.2	GO:0072602	interleukin-4 secretion(GO:0072602)
0.1	0.3	GO:0006621	protein retention in ER lumen(GO:0006621)
0.1	0.1	GO:1905005	regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.1	0.1	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.1	0.2	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.1	0.2	GO:0000727	double-strand break repair via break-induced replication(GO:0000727)
0.1	0.3	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.1	0.2	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.1	0.2	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.2	GO:0009838	abscission(GO:0009838)
0.0	0.2	GO:2000065	negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0	0.2	GO:0035627	ceramide transport(GO:0035627)
0.0	0.2	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.3	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.0	0.2	GO:1903225	negative regulation of endodermal cell differentiation(GO:1903225)
0.0	0.1	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0	0.1	GO:0048550	negative regulation of pinocytosis(GO:0048550)
0.0	0.2	GO:1904849	positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0	0.4	GO:0002318	myeloid progenitor cell differentiation(GO:0002318)
0.0	0.4	GO:0043206	extracellular fibril organization(GO:0043206)
0.0	0.1	GO:0060591	chondroblast differentiation(GO:0060591)
0.0	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.3	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0	0.1	GO:0032907	transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910)
0.0	0.2	GO:1903423	positive regulation of synaptic vesicle recycling(GO:1903423)
0.0	0.1	GO:0048548	regulation of pinocytosis(GO:0048548)
0.0	0.3	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	1.0	GO:0032620	interleukin-17 production(GO:0032620)
0.0	0.2	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.5	GO:0048385	regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.0	0.1	GO:0031627	telomeric loop formation(GO:0031627)
0.0	0.1	GO:0042668	auditory receptor cell fate determination(GO:0042668)
0.0	0.1	GO:0086068	Purkinje myocyte to ventricular cardiac muscle cell signaling(GO:0086029) Purkinje myocyte to ventricular cardiac muscle cell communication(GO:0086068)
0.0	0.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.2	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.2	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.0	0.2	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0	0.1	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.2	GO:0043313	regulation of neutrophil degranulation(GO:0043313)
0.0	0.2	GO:0031999	negative regulation of fatty acid beta-oxidation(GO:0031999)
0.0	0.1	GO:0021593	rhombomere morphogenesis(GO:0021593)
0.0	0.0	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.1	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.2	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.0	0.1	GO:0035483	gastric emptying(GO:0035483)
0.0	0.2	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.1	GO:0060447	bud outgrowth involved in lung branching(GO:0060447)
0.0	0.3	GO:0021877	forebrain neuron fate commitment(GO:0021877)
0.0	0.1	GO:0035964	COPI-coated vesicle budding(GO:0035964)
0.0	0.1	GO:0014816	skeletal muscle satellite cell differentiation(GO:0014816)
0.0	0.1	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.1	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0000101	sulfur amino acid transport(GO:0000101)
0.0	0.1	GO:0051890	regulation of cardioblast differentiation(GO:0051890)
0.0	0.1	GO:2000275	regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.0	0.1	GO:0060509	Type I pneumocyte differentiation(GO:0060509)
0.0	0.1	GO:0090187	positive regulation of pancreatic juice secretion(GO:0090187)
0.0	0.1	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.0	0.2	GO:0019720	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:0035822	meiotic gene conversion(GO:0006311) gene conversion(GO:0035822)
0.0	0.2	GO:0071501	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.0	GO:0030421	defecation(GO:0030421)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.2	GO:0060087	relaxation of vascular smooth muscle(GO:0060087)
0.0	0.1	GO:0090209	negative regulation of triglyceride metabolic process(GO:0090209)
0.0	0.0	GO:0007529	establishment of synaptic specificity at neuromuscular junction(GO:0007529)
0.0	0.3	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.1	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0	0.1	GO:0009233	menaquinone metabolic process(GO:0009233)
0.0	0.1	GO:0061144	alveolar secondary septum development(GO:0061144)
0.0	0.2	GO:2000643	positive regulation of early endosome to late endosome transport(GO:2000643)
0.0	0.1	GO:2000686	regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0	0.1	GO:0000087	mitotic M phase(GO:0000087)
0.0	0.1	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	0.3	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0	0.0	GO:2000211	regulation of glutamate metabolic process(GO:2000211)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:1902302	regulation of potassium ion export(GO:1902302)
0.0	0.3	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.1	GO:0014042	positive regulation of neuron maturation(GO:0014042)
0.0	0.1	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.0	GO:0003213	cardiac right atrium morphogenesis(GO:0003213)
0.0	0.4	GO:0010718	positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0	0.1	GO:0002870	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0	0.1	GO:0046878	positive regulation of saliva secretion(GO:0046878)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.1	GO:0002322	B cell proliferation involved in immune response(GO:0002322)
0.0	0.1	GO:0033326	cerebrospinal fluid secretion(GO:0033326)
0.0	0.0	GO:1901490	regulation of lymphangiogenesis(GO:1901490) positive regulation of lymphangiogenesis(GO:1901492)
0.0	0.1	GO:0006624	vacuolar protein processing(GO:0006624)
0.0	0.1	GO:0097212	lysosomal membrane organization(GO:0097212)
0.0	0.1	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.0	0.0	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.0	GO:0002752	cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.0	0.2	GO:0007288	sperm axoneme assembly(GO:0007288)
0.0	0.1	GO:0014738	regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.0	0.2	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.2	GO:0033574	response to testosterone(GO:0033574)
0.0	0.1	GO:0061092	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0	0.0	GO:0060331	negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.0	0.1	GO:1903689	regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.0	0.0	GO:0090091	positive regulation of extracellular matrix disassembly(GO:0090091)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.0	GO:0010649	regulation of cell communication by electrical coupling(GO:0010649)
0.0	0.1	GO:0010626	negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.3	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.0	0.0	GO:0071873	response to norepinephrine(GO:0071873)
0.0	0.0	GO:1990036	calcium ion import into sarcoplasmic reticulum(GO:1990036)
0.0	0.0	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.0	GO:1904995	negative regulation of leukocyte tethering or rolling(GO:1903237) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
0.0	0.0	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.0	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.2	GO:0035873	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0	0.0	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0060700	regulation of ribonuclease activity(GO:0060700)
0.0	0.2	GO:0044458	motile cilium assembly(GO:0044458)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.1	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0	0.1	GO:0016139	glycoside catabolic process(GO:0016139)
0.0	0.0	GO:0032466	negative regulation of cytokinesis(GO:0032466)
0.0	0.0	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.2	GO:0060707	trophoblast giant cell differentiation(GO:0060707)
0.0	0.1	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0	0.1	GO:0071404	cellular response to low-density lipoprotein particle stimulus(GO:0071404)
0.0	0.0	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.0	0.0	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.0	0.1	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.0	0.0	GO:0007223	Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.2	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.0	GO:1902075	cellular response to salt(GO:1902075)
0.0	0.0	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.1	GO:0032811	negative regulation of epinephrine secretion(GO:0032811)
0.0	0.3	GO:0036075	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0	0.1	GO:2001166	regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0	0.0	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0	0.1	GO:0031274	positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.0	GO:0033030	negative regulation of neutrophil apoptotic process(GO:0033030)
0.0	0.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.1	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.2	GO:0044247	glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0	0.0	GO:1903288	regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.0	0.0	GO:2000645	negative regulation of receptor catabolic process(GO:2000645)
0.0	0.0	GO:0010624	regulation of Schwann cell proliferation(GO:0010624)
0.0	0.1	GO:0070314	G1 to G0 transition(GO:0070314)
0.0	0.0	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.0	0.0	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.1	GO:0045618	positive regulation of keratinocyte differentiation(GO:0045618)
0.0	0.1	GO:1990845	diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.0	0.1	GO:1903392	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of adherens junction organization(GO:1903392)
0.0	0.0	GO:0032439	endosome localization(GO:0032439)
0.0	0.1	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.3	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.1	GO:0035721	intraciliary retrograde transport(GO:0035721)
0.0	0.0	GO:0060399	positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0	0.0	GO:0035582	sequestering of BMP in extracellular matrix(GO:0035582)
0.0	0.1	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0	0.0	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.7	GO:0007229	integrin-mediated signaling pathway(GO:0007229)
0.0	0.0	GO:0010728	regulation of hydrogen peroxide biosynthetic process(GO:0010728)
0.0	0.1	GO:0015074	DNA integration(GO:0015074)
0.0	0.0	GO:1904261	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0	0.1	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.0	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.2	GO:0042249	establishment of planar polarity of embryonic epithelium(GO:0042249)
0.0	0.1	GO:0000042	protein targeting to Golgi(GO:0000042)
0.0	0.2	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.0	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.0	GO:0014053	negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.0	0.1	GO:1901660	calcium ion export(GO:1901660)
0.0	0.2	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0006995	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0	0.1	GO:0014733	regulation of skeletal muscle adaptation(GO:0014733)
0.0	0.0	GO:0060689	cell differentiation involved in salivary gland development(GO:0060689)
0.0	0.1	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.1	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.2	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.1	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.9	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.6	GO:0031258	lamellipodium membrane(GO:0031258)
0.1	1.1	GO:0042612	MHC class I protein complex(GO:0042612)
0.1	0.2	GO:0097512	cardiac myofibril(GO:0097512)
0.1	0.5	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1	0.2	GO:0000811	GINS complex(GO:0000811)
0.1	0.4	GO:0098651	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1	0.2	GO:0005588	collagen type V trimer(GO:0005588)
0.1	0.2	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.1	0.7	GO:0005916	fascia adherens(GO:0005916)
0.1	0.3	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.1	0.4	GO:0030314	junctional membrane complex(GO:0030314)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.0	0.2	GO:0097209	epidermal lamellar body(GO:0097209)
0.0	0.1	GO:1990393	3M complex(GO:1990393)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.4	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.6	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.3	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.2	GO:0031314	extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0	0.2	GO:0090543	Flemming body(GO:0090543)
0.0	0.1	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.3	GO:0070938	contractile ring(GO:0070938)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.1	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	0.1	GO:0044393	microspike(GO:0044393)
0.0	0.1	GO:0017133	mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0	0.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.2	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.1	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.5	GO:0008305	integrin complex(GO:0008305)
0.0	0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.3	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0	0.2	GO:0098827	endoplasmic reticulum subcompartment(GO:0098827)
0.0	0.3	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0005944	phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0	0.1	GO:0005785	signal recognition particle receptor complex(GO:0005785)
0.0	0.1	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.1	GO:0097452	GAIT complex(GO:0097452)
0.0	0.1	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.0	0.1	GO:0097470	ribbon synapse(GO:0097470)
0.0	0.1	GO:0000439	core TFIIH complex(GO:0000439)
0.0	0.3	GO:0002102	podosome(GO:0002102)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0030991	intraciliary transport particle A(GO:0030991)
0.0	0.1	GO:0019815	B cell receptor complex(GO:0019815)
0.0	0.1	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.0	0.1	GO:0070187	telosome(GO:0070187)
0.0	0.1	GO:0043657	host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.0	0.1	GO:0042583	chromaffin granule(GO:0042583)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.0	GO:0005927	muscle tendon junction(GO:0005927)
0.0	0.1	GO:0033503	HULC complex(GO:0033503)
0.0	0.2	GO:0043196	varicosity(GO:0043196)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.3	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	0.1	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.0	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.3	GO:0031902	late endosome membrane(GO:0031902)
0.0	0.1	GO:0089701	U2AF(GO:0089701)
0.0	0.1	GO:0097431	mitotic spindle pole(GO:0097431)
0.0	0.0	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.8	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.2	0.2	GO:0003896	DNA primase activity(GO:0003896)
0.1	0.6	GO:0071253	connexin binding(GO:0071253)
0.1	0.4	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.1	0.4	GO:0046923	ER retention sequence binding(GO:0046923)
0.1	0.3	GO:0019770	IgG receptor activity(GO:0019770)
0.1	0.3	GO:0070698	type I activin receptor binding(GO:0070698)
0.1	0.3	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.1	0.2	GO:0070573	metallodipeptidase activity(GO:0070573)
0.1	0.2	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.1	0.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.5	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.1	0.2	GO:0015087	cobalt ion transmembrane transporter activity(GO:0015087)
0.1	0.2	GO:0034191	apolipoprotein A-I receptor binding(GO:0034191)
0.1	0.2	GO:0070052	collagen V binding(GO:0070052)
0.1	0.3	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.1	0.3	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.1	0.2	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.0	0.5	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.6	GO:0001972	retinoic acid binding(GO:0001972)
0.0	0.8	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.1	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.0	0.1	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.2	GO:0052724	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0	0.2	GO:0009374	biotin binding(GO:0009374)
0.0	0.2	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.1	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)
0.0	0.2	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	1.2	GO:0042605	peptide antigen binding(GO:0042605)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.2	GO:0008193	tRNA guanylyltransferase activity(GO:0008193)
0.0	0.1	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0	0.1	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.2	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.5	GO:0043295	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.2	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.2	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.0	0.7	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.2	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:2001069	glycogen binding(GO:2001069)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0	0.0	GO:0030351	inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity(GO:0030351) inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity(GO:0030352) inositol pentakisphosphate phosphatase activity(GO:0052827)
0.0	0.1	GO:0052622	4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.0	0.2	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0071209	U7 snRNA binding(GO:0071209)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.4	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	1.1	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.3	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	0.1	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.1	GO:0036122	BMP binding(GO:0036122)
0.0	0.1	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.2	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.2	GO:0043138	3'-5' DNA helicase activity(GO:0043138)
0.0	0.0	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.2	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0031545	peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.4	GO:0051059	NF-kappaB binding(GO:0051059)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.3	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.0	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	1.0	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.1	GO:0016783	sulfurtransferase activity(GO:0016783)
0.0	0.2	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.2	GO:0046965	retinoid X receptor binding(GO:0046965)
0.0	0.1	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.0	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.0	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.2	GO:0043236	laminin binding(GO:0043236)
0.0	0.0	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.0	GO:0038064	collagen receptor activity(GO:0038064)
0.0	0.1	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.0	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.4	GO:0051723	protein methylesterase activity(GO:0051723)
0.0	1.0	GO:0005178	integrin binding(GO:0005178)
0.0	0.0	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.3	GO:0030552	cAMP binding(GO:0030552)
0.0	0.1	GO:0098505	G-rich strand telomeric DNA binding(GO:0098505)
0.0	0.0	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0	0.0	GO:0019198	transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.2	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0042974	retinoic acid receptor binding(GO:0042974)
0.0	0.1	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.1	GO:0103116	alpha-D-galactofuranose transporter activity(GO:0103116)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.6	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	1.1	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	0.7	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.7	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	0.1	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.7	PID FGF PATHWAY	FGF signaling pathway
0.0	0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.3	ST GAQ PATHWAY	G alpha q Pathway
0.0	0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.5	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	0.2	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.4	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	0.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.1	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.3	NABA COLLAGENS	Genes encoding collagen proteins
0.0	0.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	1.5	NABA CORE MATRISOME	Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0	0.3	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	0.3	PID BMP PATHWAY	BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.1	0.8	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	0.8	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	1.0	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.5	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.6	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.0	0.0	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	0.4	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.4	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.0	0.4	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.8	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	1.5	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	0.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.3	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.4	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	0.0	REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0	0.4	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.0	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.1	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.0	0.6	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	0.2	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.2	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.0	0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.1	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.0	0.2	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.0	REACTOME METABOLISM OF RNA	Genes involved in Metabolism of RNA
0.0	0.1	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions