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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Trp63

Z-value: 0.29

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Transcription factors associated with Trp63

Gene Symbol	Gene ID	Gene Info
Trp63 Ensembl NCBI MGI UniProt	ENSMUSG00000022510.8	Trp63

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Trp63	chr16_25684291_25684442	601	0.776410	0.38	2.6e-03	Click!
Trp63	chr16_25683728_25684269	233	0.942184	0.26	4.8e-02	Click!
Trp63	chr16_25804319_25804643	2565	0.377228	0.09	5.1e-01	Click!
Trp63	chr16_25806162_25806335	4332	0.308764	-0.08	5.3e-01	Click!
Trp63	chr16_25804012_25804163	2171	0.412444	0.07	6.1e-01	Click!

Activity of the Trp63 motif across conditions

Conditions sorted by the z-value of the Trp63 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr16_90738322_90739000	0.26	Mrap	melanocortin 2 receptor accessory protein	337	0.85
chr2_32081622_32082932	0.26	Fam78a	family with sequence similarity 78, member A	1506	0.26
chr15_98601965_98602724	0.24	Adcy6	adenylate cyclase 6	2387	0.14
chr12_74013636_74013876	0.24	Syt16	synaptotagmin XVI	15957	0.17
chr15_77754933_77755315	0.21	Apol8	apolipoprotein L 8	115	0.93
chr6_117918083_117918316	0.19	Gm43863	predicted gene, 43863	477	0.57
chr15_83169184_83169335	0.19	Cyb5r3	cytochrome b5 reductase 3	918	0.4
chr11_98910013_98910427	0.19	Cdc6	cell division cycle 6	2069	0.19
chr16_19982574_19983084	0.18	Klhl6	kelch-like 6	101	0.97
chr2_91120847_91121416	0.18	Mybpc3	myosin binding protein C, cardiac	2987	0.16
chr14_31576784_31577279	0.18	Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	352	0.85
chr8_122282435_122282616	0.17	Zfpm1	zinc finger protein, multitype 1	384	0.83
chr8_80497324_80498362	0.17	Gypa	glycophorin A	4062	0.27
chr8_70476235_70476894	0.17	Klhl26	kelch-like 26	341	0.75
chr1_135839302_135839453	0.17	Tnnt2	troponin T2, cardiac	1322	0.34
chr11_32288387_32289175	0.16	Hbq1b	hemoglobin, theta 1B	1780	0.2
chr10_128494842_128495139	0.16	Myl6b	myosin, light polypeptide 6B	566	0.4
chr17_47595220_47595679	0.16	Ccnd3	cyclin D3	619	0.57
chr3_152477886_152478987	0.16	Ak5	adenylate kinase 5	79	0.97
chr8_57513444_57513905	0.15	Hmgb2	high mobility group box 2	1126	0.33
chr7_44468072_44469106	0.15	Josd2	Josephin domain containing 2	237	0.75
chr4_141421681_141422558	0.15	Hspb7	heat shock protein family, member 7 (cardiovascular)	1340	0.25
chr15_36606762_36607275	0.15	Pabpc1	poly(A) binding protein, cytoplasmic 1	1552	0.29
chr11_55184284_55185056	0.15	Slc36a2	solute carrier family 36 (proton/amino acid symporter), member 2	407	0.78
chr6_47191483_47191919	0.14	Cntnap2	contactin associated protein-like 2	52686	0.16
chr1_51288641_51290950	0.14	Cavin2	caveolae associated 2	669	0.72
chr2_59829432_59829769	0.14	Tanc1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	12140	0.22
chr11_114198650_114199013	0.14	1700092K14Rik	RIKEN cDNA 1700092K14 gene	573	0.74
chr9_103305951_103306102	0.14	Topbp1	topoisomerase (DNA) II binding protein 1	523	0.61
chr1_135837715_135838209	0.14	Tnnt2	troponin T2, cardiac	1549	0.29
chr11_117784224_117784441	0.14	Gm11723	predicted gene 11723	723	0.4
chr12_28804949_28805160	0.14	Gm48905	predicted gene, 48905	5084	0.18
chr17_24250421_24251368	0.14	Ccnf	cyclin F	424	0.68
chr9_75441517_75442270	0.13	Leo1	Leo1, Paf1/RNA polymerase II complex component	357	0.81
chr6_146220976_146221548	0.13	Itpr2	inositol 1,4,5-triphosphate receptor 2	6281	0.26
chr3_153689877_153690164	0.13	Gm22206	predicted gene, 22206	18891	0.16
chr7_17027108_17027849	0.13	Ppp5c	protein phosphatase 5, catalytic subunit	137	0.93
chr19_55926597_55927105	0.12	Tcf7l2	transcription factor 7 like 2, T cell specific, HMG box	28542	0.21
chr1_82288297_82288775	0.12	Irs1	insulin receptor substrate 1	2880	0.26
chr19_43520527_43520933	0.12	Got1	glutamic-oxaloacetic transaminase 1, soluble	3755	0.15
chr9_21526198_21526743	0.12	AB124611	cDNA sequence AB124611	242	0.85
chr2_26012349_26012671	0.12	Ubac1	ubiquitin associated domain containing 1	1557	0.29
chr11_90726819_90728183	0.12	Tom1l1	target of myb1-like 1 (chicken)	39135	0.15
chr7_24373502_24374343	0.12	Kcnn4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	3584	0.11
chr3_138067510_138069146	0.12	Gm5105	predicted gene 5105	940	0.46
chrX_11664777_11665621	0.12	Gm14513	predicted gene 14513	18925	0.24
chr3_101551232_101552184	0.12	Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	25852	0.16
chr12_24963377_24963763	0.12	Kidins220	kinase D-interacting substrate 220	11355	0.18
chr11_69947014_69948171	0.12	Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	382	0.6
chr19_40376409_40376771	0.12	Sorbs1	sorbin and SH3 domain containing 1	284	0.93
chr6_31612888_31614126	0.11	Gm43154	predicted gene 43154	8218	0.19
chr6_125349094_125349245	0.11	Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	193	0.91
chr13_75711286_75711461	0.11	Ell2	elongation factor RNA polymerase II 2	3662	0.15
chr19_10578600_10578808	0.11	Cyb561a3	cytochrome b561 family, member A3	692	0.43
chr9_21015148_21016366	0.11	Icam1	intercellular adhesion molecule 1	228	0.81
chr12_112942194_112942430	0.11	Nudt14	nudix (nucleoside diphosphate linked moiety X)-type motif 14	188	0.88
chr11_32250575_32250853	0.11	Nprl3	nitrogen permease regulator-like 3	436	0.71
chr4_88550254_88550926	0.11	Ifna15	interferon alpha 15	7655	0.1
chr15_77815874_77816114	0.11	Myh9	myosin, heavy polypeptide 9, non-muscle	2763	0.21
chr16_37539321_37539726	0.11	Gtf2e1	general transcription factor II E, polypeptide 1 (alpha subunit)	253	0.6
chr13_28770503_28770945	0.11	Gm17528	predicted gene, 17528	56399	0.12
chr18_35847749_35850271	0.11	Cxxc5	CXXC finger 5	5677	0.11
chr6_137410715_137411297	0.11	Ptpro	protein tyrosine phosphatase, receptor type, O	247	0.94
chr1_135840170_135841177	0.11	Tnnt2	troponin T2, cardiac	26	0.97
chr7_136894579_136895285	0.11	Mgmt	O-6-methylguanine-DNA methyltransferase	318	0.92
chr9_113930385_113930581	0.11	Ubp1	upstream binding protein 1	451	0.84
chr7_4866688_4866875	0.11	Isoc2b	isochorismatase domain containing 2b	588	0.52
chr11_55411877_55412028	0.11	Sparc	secreted acidic cysteine rich glycoprotein	7946	0.16
chr1_193382120_193382498	0.11	Camk1g	calcium/calmodulin-dependent protein kinase I gamma	12011	0.15
chr13_29854543_29854861	0.10	Cdkal1	CDK5 regulatory subunit associated protein 1-like 1	729	0.77
chr8_45658542_45659771	0.10	Sorbs2	sorbin and SH3 domain containing 2	352	0.89
chr11_58918885_58919318	0.10	Btnl10	butyrophilin-like 10	1044	0.25
chr15_83147790_83147941	0.10	Poldip3	polymerase (DNA-directed), delta interacting protein 3	1436	0.23
chr3_69005043_69005730	0.10	Smc4	structural maintenance of chromosomes 4	371	0.66
chr6_141273994_141274145	0.10	Gm28523	predicted gene 28523	24060	0.19
chr3_100921543_100921984	0.10	Trim45	tripartite motif-containing 45	439	0.82
chr9_56505872_56506042	0.10	Gm47175	predicted gene, 47175	704	0.65
chr8_122719956_122721464	0.10	C230057M02Rik	RIKEN cDNA C230057M02 gene	17801	0.09
chr13_111894572_111895253	0.10	Gm9025	predicted gene 9025	10735	0.15
chr8_85432612_85432832	0.10	1700051O22Rik	RIKEN cDNA 1700051O22 Gene	36	0.56
chr1_78568355_78568575	0.10	Mogat1	monoacylglycerol O-acyltransferase 1	30837	0.13
chr17_12764355_12764670	0.10	Igf2r	insulin-like growth factor 2 receptor	5152	0.13
chr6_38900943_38901392	0.10	Tbxas1	thromboxane A synthase 1, platelet	17813	0.19
chr8_75089284_75089957	0.10	Hmox1	heme oxygenase 1	4001	0.16
chr6_120467285_120467457	0.10	Il17ra	interleukin 17 receptor A	4124	0.17
chr11_32671444_32671658	0.10	Fbxw11	F-box and WD-40 domain protein 11	28647	0.18
chr15_85634869_85635356	0.10	Gm49539	predicted gene, 49539	10971	0.15
chr7_110777775_110778052	0.10	Ampd3	adenosine monophosphate deaminase 3	223	0.91
chr7_19226915_19227555	0.10	Opa3	optic atrophy 3	1099	0.27
chr2_119972478_119973221	0.10	Mapkbp1	mitogen-activated protein kinase binding protein 1	54	0.96
chr14_63946096_63946930	0.10	Sox7	SRY (sex determining region Y)-box 7	2840	0.24
chr1_138912105_138912653	0.10	Gm3933	predicted gene 3933	3664	0.15
chrX_132102482_132102633	0.10	Gm7058	predicted gene 7058	67550	0.13
chr5_33272179_33273173	0.10	Ctbp1	C-terminal binding protein 1	1903	0.28
chr11_119392783_119393622	0.09	Rnf213	ring finger protein 213	102	0.95
chr14_65832957_65833923	0.09	Esco2	establishment of sister chromatid cohesion N-acetyltransferase 2	468	0.79
chr10_127289828_127290445	0.09	Gm4189	predicted gene 4189	588	0.31
chr3_139308377_139308557	0.09	Stpg2	sperm tail PG rich repeat containing 2	102574	0.07
chr12_84709717_84709962	0.09	Syndig1l	synapse differentiation inducing 1 like	11008	0.15
chr7_92873732_92874248	0.09	Ddias	DNA damage-induced apoptosis suppressor	186	0.77
chr16_18428270_18428753	0.09	Txnrd2	thioredoxin reductase 2	186	0.88
chr16_3846654_3847068	0.09	Zfp174	zinc finger protein 174	407	0.71
chr4_107253592_107253822	0.09	Hspb11	heat shock protein family B (small), member 11	114	0.58
chr3_131334397_131335246	0.09	Sgms2	sphingomyelin synthase 2	10112	0.15
chr12_109454496_109454673	0.09	Dlk1	delta like non-canonical Notch ligand 1	389	0.74
chr3_84189087_84189700	0.09	Trim2	tripartite motif-containing 2	1130	0.52
chr3_159847798_159848044	0.09	Wls	wntless WNT ligand secretion mediator	530	0.83
chr11_8501968_8502413	0.09	Tns3	tensin 3	33515	0.23
chr11_45926491_45926959	0.09	Lsm11	U7 snRNP-specific Sm-like protein LSM11	18210	0.14
chr6_119196453_119196655	0.09	Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	136	0.96
chr5_116420481_116421179	0.09	Hspb8	heat shock protein 8	2034	0.22
chr5_135777784_135778296	0.09	Styxl1	serine/threonine/tyrosine interacting-like 1	198	0.71
chr6_55203433_55204260	0.09	Mindy4	MINDY lysine 48 deubiquitinase 4	463	0.81
chr8_94986231_94987228	0.09	Adgrg1	adhesion G protein-coupled receptor G1	1161	0.36
chr4_135353535_135353968	0.09	Srrm1	serine/arginine repetitive matrix 1	430	0.73
chr7_102246806_102247734	0.09	Rhog	ras homolog family member G	2818	0.17
chr1_166124763_166124914	0.09	Dusp27	dual specificity phosphatase 27 (putative)	3058	0.21
chr16_91169710_91170388	0.09	Gm49613	predicted gene, 49613	5285	0.13
chr1_74049307_74049652	0.09	Tns1	tensin 1	12322	0.21
chr10_127290769_127291873	0.09	Ddit3	DNA-damage inducible transcript 3	492	0.37
chr1_135768530_135768972	0.09	Phlda3	pleckstrin homology like domain, family A, member 3	1617	0.31
chr4_115092064_115093406	0.09	Pdzk1ip1	PDZK1 interacting protein 1	1803	0.28
chr12_51058382_51058886	0.09	Gm22088	predicted gene, 22088	27053	0.18
chr11_101094859_101095385	0.09	Psmc3ip	proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein	254	0.81
chr19_43921380_43921848	0.09	Gm50217	predicted gene, 50217	1141	0.4
chr11_101627997_101628632	0.08	Rdm1	RAD52 motif 1	75	0.9
chr1_58029648_58030887	0.08	Aox1	aldehyde oxidase 1	303	0.89
chr5_117133717_117134877	0.08	Taok3	TAO kinase 3	656	0.62
chr14_54252799_54253017	0.08	Dad1	defender against cell death 1	1006	0.28
chr5_75607943_75608525	0.08	Kit	KIT proto-oncogene receptor tyrosine kinase	2340	0.34
chr4_132973841_132975368	0.08	Fgr	FGR proto-oncogene, Src family tyrosine kinase	502	0.76
chr10_80899333_80899562	0.08	Timm13	translocase of inner mitochondrial membrane 13	1335	0.24
chr3_41081759_41082908	0.08	Pgrmc2	progesterone receptor membrane component 2	713	0.68
chr17_33555776_33556414	0.08	Myo1f	myosin IF	330	0.85
chr7_48991870_48992129	0.08	Nav2	neuron navigator 2	32902	0.14
chr16_75906235_75906386	0.08	Samsn1	SAM domain, SH3 domain and nuclear localization signals, 1	2969	0.33
chr9_44110354_44111126	0.08	Gm47327	predicted gene, 47327	169	0.8
chr3_137342527_137342893	0.08	Emcn	endomucin	1536	0.49
chr7_141442950_141444299	0.08	Pidd1	p53 induced death domain protein 1	268	0.74
chr2_9877985_9878236	0.08	Gata3	GATA binding protein 3	490	0.56
chr17_79348163_79348612	0.08	Cdc42ep3	CDC42 effector protein (Rho GTPase binding) 3	4620	0.24
chr5_115509295_115510185	0.08	Pxn	paxillin	2884	0.12
chr1_59579877_59580151	0.08	Gm973	predicted gene 973	2382	0.23
chr9_123366984_123367730	0.08	Lars2	leucyl-tRNA synthetase, mitochondrial	354	0.88
chr7_141010753_141011069	0.08	Ifitm3	interferon induced transmembrane protein 3	141	0.89
chr8_120535808_120536639	0.08	Gse1	genetic suppressor element 1, coiled-coil protein	366	0.73
chr13_25562934_25563111	0.08	Gm11349	predicted gene 11349	20364	0.25
chr11_69095229_69096278	0.08	Per1	period circadian clock 1	536	0.52
chr19_24527047_24527577	0.08	Pip5k1b	phosphatidylinositol-4-phosphate 5-kinase, type 1 beta	28477	0.16
chr2_163354062_163354414	0.08	Tox2	TOX high mobility group box family member 2	33860	0.12
chr1_82288792_82289141	0.08	Irs1	insulin receptor substrate 1	2450	0.28
chr5_149184724_149185776	0.08	Uspl1	ubiquitin specific peptidase like 1	469	0.47
chrX_164074168_164074319	0.08	Siah1b	siah E3 ubiquitin protein ligase 1B	1878	0.31
chr8_18738571_18739759	0.08	Angpt2	angiopoietin 2	2397	0.3
chr17_45573465_45573903	0.08	Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	413	0.69
chr11_100967422_100967790	0.08	Cavin1	caveolae associated 1	2945	0.18
chr7_144489028_144489179	0.08	Ppfia1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	234	0.92
chr13_37482944_37483624	0.08	Gm47732	predicted gene, 47732	899	0.41
chr6_125491631_125492511	0.07	Gm26728	predicted gene, 26728	2353	0.22
chr7_46554047_46554198	0.07	Gm15700	predicted gene 15700	7179	0.15
chr2_120154741_120155150	0.07	Ehd4	EH-domain containing 4	339	0.87
chr11_11828454_11829202	0.07	Ddc	dopa decarboxylase	5907	0.2
chr12_110022984_110023602	0.07	Gm34667	predicted gene, 34667	580	0.67
chr11_103158442_103159191	0.07	Fmnl1	formin-like 1	12291	0.11
chr16_91466275_91466861	0.07	Gm49626	predicted gene, 49626	1443	0.19
chr1_125678382_125678847	0.07	Gpr39	G protein-coupled receptor 39	1619	0.44
chr10_8427639_8427823	0.07	Ust	uronyl-2-sulfotransferase	91094	0.09
chr10_60752050_60752803	0.07	Slc29a3	solute carrier family 29 (nucleoside transporters), member 3	356	0.89
chr13_43158853_43159330	0.07	Tbc1d7	TBC1 domain family, member 7	217	0.94
chr10_91083048_91083580	0.07	Ikbip	IKBKB interacting protein	194	0.79
chr9_104063750_104064058	0.07	Acad11	acyl-Coenzyme A dehydrogenase family, member 11	171	0.84
chr2_52619696_52619936	0.07	Bloc1s2-ps	biogenesis of lysosomal organelles complex-1, subunit 2, pseudogene	62	0.98
chr13_3866217_3866406	0.07	Calm5	calmodulin 5	12043	0.11
chr14_70521525_70521739	0.07	Sftpc	surfactant associated protein C	544	0.57
chr13_20900415_20900566	0.07	Gm25605	predicted gene, 25605	55736	0.12
chr16_93885679_93885894	0.07	Chaf1b	chromatin assembly factor 1, subunit B (p60)	1584	0.28
chr2_103895883_103896333	0.07	Gm13876	predicted gene 13876	7784	0.12
chr15_73791907_73792230	0.07	Ndufb4c	NADH:ubiquinone oxidoreductase subunit B4C	17828	0.15
chr10_71347309_71347708	0.07	Ipmk	inositol polyphosphate multikinase	255	0.88
chr3_98267489_98267783	0.07	Hmgcs2	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	12799	0.13
chr3_96404203_96405307	0.07	Gm26654	predicted gene, 26654	2374	0.09
chr11_89056720_89056879	0.07	Dgke	diacylglycerol kinase, epsilon	3949	0.15
chr2_91964507_91965860	0.07	Dgkz	diacylglycerol kinase zeta	404	0.78
chr19_24378594_24378946	0.07	Pip5k1bos	phosphatidylinositol-4-phosphate 5-kinase, type 1 beta, opposite strand	37239	0.15
chr11_68850735_68851370	0.07	Ndel1	nudE neurodevelopment protein 1 like 1	1989	0.24
chr14_7774273_7774663	0.07	Gm10044	predicted gene 10044	329	0.85
chr17_81064219_81065026	0.07	Thumpd2	THUMP domain containing 2	445	0.89
chr9_51009335_51009739	0.07	Sik2	salt inducible kinase 2	464	0.81
chr2_167833410_167833763	0.07	1200007C13Rik	RIKEN cDNA 1200007C13 gene	60	0.97
chr3_99965564_99965715	0.07	Rpl36-ps7	ribosomal protein L36, pseudogene 7	42721	0.16
chr2_30981192_30981821	0.07	BC005624	cDNA sequence BC005624	435	0.61
chr17_33018251_33018434	0.07	Zfp763	zinc finger protein 763	14826	0.12
chr6_54329484_54329647	0.07	9130019P16Rik	RIKEN cDNA 9130019P16 gene	2224	0.26
chr12_73908042_73908546	0.07	Hif1a	hypoxia inducible factor 1, alpha subunit	390	0.84
chr1_179581898_179582278	0.07	Cnst	consortin, connexin sorting protein	11302	0.17
chr11_69408850_69409533	0.07	Kdm6b	KDM1 lysine (K)-specific demethylase 6B	4484	0.09
chr2_145933841_145934674	0.07	Crnkl1	crooked neck pre-mRNA splicing factor 1	457	0.5
chr7_118853827_118853990	0.07	Knop1	lysine rich nucleolar protein 1	1705	0.25
chr19_57358602_57359019	0.06	Fam160b1	family with sequence similarity 160, member B1	1870	0.25
chr2_163658129_163658339	0.06	Pkig	protein kinase inhibitor, gamma	152	0.94

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp63

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.0	0.2	GO:0003228	atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0	0.1	GO:0035524	proline transmembrane transport(GO:0035524)
0.0	0.1	GO:0060374	mast cell differentiation(GO:0060374)
0.0	0.2	GO:0008582	regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.0	0.1	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.1	GO:0044650	virion attachment to host cell(GO:0019062) adhesion of symbiont to host cell(GO:0044650)
0.0	0.1	GO:0061356	Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356)
0.0	0.1	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061419)
0.0	0.1	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0021943	formation of radial glial scaffolds(GO:0021943)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0000320	re-entry into mitotic cell cycle(GO:0000320)
0.0	0.1	GO:0035625	receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.0	0.1	GO:0032264	IMP salvage(GO:0032264)
0.0	0.1	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0	0.1	GO:0070094	positive regulation of glucagon secretion(GO:0070094)
0.0	0.1	GO:0003105	negative regulation of glomerular filtration(GO:0003105)
0.0	0.1	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.0	GO:0045914	negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.0	0.1	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.1	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.0	GO:0021524	visceral motor neuron differentiation(GO:0021524)
0.0	0.0	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.0	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.0	GO:0097167	circadian regulation of translation(GO:0097167)
0.0	0.1	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.0	0.1	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.0	GO:0002554	serotonin secretion by platelet(GO:0002554)
0.0	0.0	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.2	GO:0002467	germinal center formation(GO:0002467)
0.0	0.0	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.0	0.0	GO:0019478	D-amino acid catabolic process(GO:0019478)
0.0	0.0	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.0	GO:0030576	Cajal body organization(GO:0030576)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.0	GO:2000474	regulation of opioid receptor signaling pathway(GO:2000474)
0.0	0.1	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0	0.1	GO:0043312	neutrophil degranulation(GO:0043312)
0.0	0.1	GO:0033523	histone H2B ubiquitination(GO:0033523)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.0	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.0	0.0	GO:0045196	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0	0.0	GO:0039689	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:1990635	proximal dendrite(GO:1990635)
0.0	0.2	GO:0005861	troponin complex(GO:0005861)
0.0	0.1	GO:1990130	Iml1 complex(GO:1990130)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.1	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.1	GO:0030313	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.1	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.0	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.1	0.2	GO:0030172	troponin C binding(GO:0030172)
0.0	0.1	GO:0043120	tumor necrosis factor binding(GO:0043120)
0.0	0.1	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.0	0.1	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.1	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.1	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	0.1	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.0	0.1	GO:0015563	uptake transmembrane transporter activity(GO:0015563)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.2	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.0	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0052758	4-methyloctanoyl-CoA dehydrogenase activity(GO:0034580) naphthyl-2-methyl-succinyl-CoA dehydrogenase activity(GO:0034845) 2-methylhexanoyl-CoA dehydrogenase activity(GO:0034916) propionyl-CoA dehydrogenase activity(GO:0043820) thiol-driven fumarate reductase activity(GO:0043830) coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity(GO:0052758) coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity(GO:0052759) coenzyme F420-dependent 2,4-dinitrophenol reductase activity(GO:0052760)
0.0	0.1	GO:0051765	inositol tetrakisphosphate kinase activity(GO:0051765)
0.0	0.0	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.0	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.0	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction