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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Zfp410

Z-value: 0.66

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Transcription factors associated with Zfp410

Gene Symbol	Gene ID	Gene Info
Zfp410 Ensembl NCBI MGI UniProt	ENSMUSG00000042472.10	Zfp410

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Zfp410	chr12_84316195_84316346	582	0.477805	-0.38	2.4e-03	Click!
Zfp410	chr12_84318817_84318968	1747	0.208145	0.29	2.3e-02	Click!
Zfp410	chr12_84319037_84319188	1967	0.191599	0.29	2.3e-02	Click!
Zfp410	chr12_84319266_84319417	2196	0.178225	0.28	3.1e-02	Click!
Zfp410	chr12_84318564_84318715	1494	0.233369	0.22	8.7e-02	Click!

Activity of the Zfp410 motif across conditions

Conditions sorted by the z-value of the Zfp410 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_125088526_125090642	23.56	2010008C14Rik	RIKEN cDNA 2010008C14 gene	6147	0.07
chr1_174173964_174174767	2.92	Spta1	spectrin alpha, erythrocytic 1	1589	0.22
chr16_22893216_22893797	2.90	Gm30505	predicted gene, 30505	880	0.37
chr4_32986761_32986927	2.72	Rragd	Ras-related GTP binding D	3390	0.16
chr15_78261783_78262576	2.59	Ncf4	neutrophil cytosolic factor 4	1301	0.34
chr2_31006029_31006516	2.57	Usp20	ubiquitin specific peptidase 20	3711	0.18
chr10_60077941_60078202	2.47	Spock2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2	28148	0.16
chr10_56106927_56107500	2.41	Msl3l2	MSL3 like 2	296	0.92
chr9_111146491_111146642	2.24	Lrrfip2	leucine rich repeat (in FLII) interacting protein 2	14737	0.16
chr1_184729496_184731200	2.16	Hlx	H2.0-like homeobox	1250	0.37
chr4_123284834_123285406	2.13	Pabpc4	poly(A) binding protein, cytoplasmic 4	2025	0.17
chr2_32386034_32386242	1.98	Lcn2	lipocalin 2	31	0.94
chr4_154924143_154924717	1.82	Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	3647	0.15
chr1_131525650_131527377	1.73	Srgap2	SLIT-ROBO Rho GTPase activating protein 2	834	0.47
chr6_41700699_41701150	1.72	Kel	Kell blood group	1756	0.24
chr2_131454053_131454421	1.70	Gm14304	predicted gene 14304	403	0.82
chr5_103763438_103763619	1.69	Aff1	AF4/FMR2 family, member 1	8955	0.21
chr16_26368806_26369157	1.63	Cldn1	claudin 1	2860	0.38
chr13_37581137_37581365	1.58	Gm47754	predicted gene, 47754	174	0.87
chr14_52196647_52197712	1.54	Supt16	SPT16, facilitates chromatin remodeling subunit	237	0.56
chr2_30658719_30659142	1.50	Gm14486	predicted gene 14486	10978	0.15
chr6_52178790_52180823	1.39	5730596B20Rik	RIKEN cDNA 5730596B20 gene	2308	0.09
chr1_174171570_174172092	1.30	Spta1	spectrin alpha, erythrocytic 1	945	0.37
chr7_4747526_4747677	1.24	Kmt5c	lysine methyltransferase 5C	1793	0.15
chr6_67013848_67014074	1.20	Gm15644	predicted gene 15644	1476	0.27
chr5_31887658_31887897	1.11	Gm43811	predicted gene 43811	38920	0.16
chr15_102102931_102104191	1.10	Tns2	tensin 2	573	0.62
chr14_21178664_21178815	1.04	Adk	adenosine kinase	102587	0.07
chr5_28457868_28460972	1.03	9530036O11Rik	RIKEN cDNA 9530036O11Rik	1146	0.51
chr5_100499385_100500654	1.02	Gm23222	predicted gene, 23222	199	0.78
chr15_83169748_83171160	1.01	Cyb5r3	cytochrome b5 reductase 3	52	0.95
chr4_108849566_108849717	0.91	Kti12	KTI12 homolog, chromatin associated	1856	0.25
chr15_100668768_100669476	0.91	Bin2	bridging integrator 2	383	0.73
chr5_43515484_43516406	0.88	C1qtnf7	C1q and tumor necrosis factor related protein 7	183	0.94
chr18_35555130_35555680	0.86	Snhg4	small nucleolar RNA host gene 4	734	0.29
chr14_26441045_26441600	0.86	Slmap	sarcolemma associated protein	1333	0.39
chr11_70639659_70639949	0.84	Gp1ba	glycoprotein 1b, alpha polypeptide	660	0.39
chr11_102368401_102368706	0.79	Slc4a1	solute carrier family 4 (anion exchanger), member 1	2350	0.16
chr18_74740823_74741114	0.77	Myo5b	myosin VB	7203	0.18
chr2_130576014_130578077	0.75	Oxt	oxytocin	872	0.39
chr13_5714127_5714791	0.74	Gm35330	predicted gene, 35330	9983	0.27
chr19_10023046_10023689	0.67	Rab3il1	RAB3A interacting protein (rabin3)-like 1	5102	0.13
chr7_74722253_74722404	0.66	Gm7726	predicted gene 7726	22472	0.21
chr2_6128217_6128792	0.64	Proser2	proline and serine rich 2	1635	0.31
chr18_56920684_56921182	0.63	Marchf3	membrane associated ring-CH-type finger 3	4582	0.22
chr11_58961317_58962255	0.63	H3f4	H3.4 histone	26	0.92
chr3_96244511_96244662	0.60	H2ac18	H2A clustered histone 18	911	0.15
chr8_108886846_108887288	0.57	Gm38318	predicted gene, 38318	19505	0.2
chr12_71877272_71877457	0.54	Daam1	dishevelled associated activator of morphogenesis 1	12366	0.21
chr19_23687455_23688235	0.54	Ptar1	protein prenyltransferase alpha subunit repeat containing 1	101	0.95
chr8_36639144_36639295	0.53	Dlc1	deleted in liver cancer 1	25276	0.24
chr5_16553245_16554447	0.50	Hgf	hepatocyte growth factor	60	0.98
chr1_56099318_56099469	0.50	1700003I22Rik	RIKEN cDNA 1700003I22 gene	80370	0.11
chr9_13827814_13828725	0.48	Fam76b	family with sequence similarity 76, member B	534	0.64
chr3_31957151_31957302	0.47	Gm37834	predicted gene, 37834	2462	0.39
chrX_150549256_150549407	0.47	Alas2	aminolevulinic acid synthase 2, erythroid	1872	0.24
chr3_146599870_146600091	0.47	Uox	urate oxidase	2814	0.18
chr5_136810567_136811453	0.46	Col26a1	collagen, type XXVI, alpha 1	27299	0.15
chr3_84005656_84006186	0.45	Tmem131l	transmembrane 131 like	34207	0.18
chr5_137424316_137424467	0.45	Rpl36-ps9	ribosomal protein L36, pseudogene 9	8596	0.11
chr17_29115479_29115785	0.42	Rab44	RAB44, member RAS oncogene family	1451	0.24
chr4_152041050_152041419	0.42	Nol9	nucleolar protein 9	1871	0.19
chr17_24471773_24471948	0.41	Pgp	phosphoglycolate phosphatase	1425	0.15
chr14_55194266_55194459	0.41	Gm46455	predicted gene, 46455	24653	0.1
chr14_61257948_61258209	0.41	Sgcg	sarcoglycan, gamma (dystrophin-associated glycoprotein)	346	0.85
chr10_42268858_42269374	0.40	Foxo3	forkhead box O3	7580	0.26
chr7_64040303_64040644	0.39	Gm45054	predicted gene 45054	353	0.85
chr19_8929328_8930627	0.37	Eml3	echinoderm microtubule associated protein like 3	84	0.84
chr4_109253812_109254165	0.35	Calr4	calreticulin 4	9406	0.19
chr15_40674755_40675016	0.34	Zfpm2	zinc finger protein, multitype 2	9895	0.29
chr4_87801519_87801738	0.33	Mllt3	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3	4666	0.34
chr2_153495481_153495632	0.33	4930404H24Rik	RIKEN cDNA 4930404H24 gene	2766	0.24
chr3_59129690_59130148	0.33	P2ry14	purinergic receptor P2Y, G-protein coupled, 14	703	0.66
chr7_104507498_104507806	0.33	Trim30d	tripartite motif-containing 30D	173	0.89
chr1_91538647_91539044	0.32	Asb1	ankyrin repeat and SOCS box-containing 1	1699	0.3
chrX_164421189_164421355	0.32	Piga	phosphatidylinositol glycan anchor biosynthesis, class A	1312	0.41
chr9_99708109_99709014	0.31	Gm16004	predicted gene 16004	162	0.93
chrX_52151061_52151857	0.31	Gpc4	glypican 4	13793	0.28
chr1_36088938_36089276	0.30	Hs6st1	heparan sulfate 6-O-sulfotransferase 1	12583	0.13
chr18_38962190_38962341	0.30	Gm5820	predicted gene 5820	6556	0.19
chr16_90916648_90916799	0.29	Gm7831	predicted gene 7831	1543	0.24
chr1_156222209_156222829	0.29	Gm38113	predicted gene, 38113	4774	0.18
chr18_77870000_77870716	0.29	Epg5	ectopic P-granules autophagy protein 5 homolog (C. elegans)	68107	0.09
chr9_73044202_73045612	0.29	Rab27a	RAB27A, member RAS oncogene family	50	0.94
chr16_13545571_13545722	0.28	Gm25276	predicted gene, 25276	14095	0.15
chr5_145115755_145116764	0.28	Arpc1b	actin related protein 2/3 complex, subunit 1B	1943	0.18
chr10_81351824_81352381	0.27	Hmg20b	high mobility group 20B	1622	0.13
chr7_19159561_19160813	0.25	Gipr	gastric inhibitory polypeptide receptor	4907	0.08
chr5_121233582_121234161	0.24	Hectd4	HECT domain E3 ubiquitin protein ligase 4	13652	0.13
chr2_116768611_116768926	0.24	Gm13990	predicted gene 13990	108400	0.06
chr14_54958124_54958655	0.24	Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	482	0.52
chr17_35231958_35233195	0.24	Atp6v1g2	ATPase, H+ transporting, lysosomal V1 subunit G2	1084	0.18
chr5_82246250_82246401	0.24	Rpl7-ps7	ribosomal protein L7, pseudogene 7	90526	0.09
chr6_137630324_137630475	0.23	Eps8	epidermal growth factor receptor pathway substrate 8	17884	0.22
chr14_59439369_59439520	0.23	Setdb2	SET domain, bifurcated 2	1429	0.3
chr4_142166102_142166510	0.23	Kazn	kazrin, periplakin interacting protein	7252	0.19
chr13_38635539_38635690	0.23	Bloc1s5	biogenesis of lysosomal organelles complex-1, subunit 5, muted	505	0.5
chr5_114173960_114175108	0.22	Acacb	acetyl-Coenzyme A carboxylase beta	1372	0.35
chr2_180273759_180274154	0.22	Cables2	CDK5 and Abl enzyme substrate 2	460	0.72
chr17_65604240_65604425	0.22	Vapa	vesicle-associated membrane protein, associated protein A	9223	0.16
chr2_26298030_26300214	0.21	Ccdc187	coiled-coil domain containing 187	4565	0.13
chr6_29784657_29784847	0.21	Ahcyl2	S-adenosylhomocysteine hydrolase-like 2	14799	0.16
chr16_5205031_5205182	0.21	Nagpa	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	1094	0.33
chr15_83166752_83167017	0.21	Cyb5r3	cytochrome b5 reductase 3	3293	0.13
chr1_160906608_160907521	0.21	Rc3h1	RING CCCH (C3H) domains 1	646	0.5
chr7_115860217_115860368	0.21	Sox6	SRY (sex determining region Y)-box 6	440	0.9
chr17_47335038_47335189	0.20	Mrps10	mitochondrial ribosomal protein S10	33774	0.11
chr16_21787099_21788407	0.20	Ehhadh	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase	54	0.96
chr4_135405096_135405380	0.19	Gm12990	predicted gene 12990	1582	0.22
chr6_117610478_117610687	0.19	Gm45083	predicted gene 45083	1988	0.36
chr9_22155677_22155979	0.19	Pigyl	phosphatidylinositol glycan anchor biosynthesis, class Y-like	1018	0.29
chr11_72458192_72459273	0.18	Spns2	spinster homolog 2	2111	0.22
chr11_120169034_120170072	0.18	Slc38a10	solute carrier family 38, member 10	18207	0.09
chr9_29288118_29288329	0.18	Ntm	neurotrimin	102558	0.08
chr11_100964042_100964193	0.18	Cavin1	caveolae associated 1	6434	0.14
chr3_19635362_19635513	0.18	1700064H15Rik	RIKEN cDNA 1700064H15 gene	6760	0.16
chr5_123142167_123142508	0.18	Setd1b	SET domain containing 1B	144	0.83
chr5_64715305_64715496	0.18	Gm20033	predicted gene, 20033	951	0.51
chr8_75095618_75095913	0.18	Hmox1	heme oxygenase 1	1079	0.41
chr2_9918739_9918949	0.17	Taf3	TATA-box binding protein associated factor 3	10	0.96
chr15_36500071_36500348	0.17	Gm49246	predicted gene, 49246	3222	0.18
chr5_147303089_147303425	0.17	Cdx2	caudal type homeobox 2	4013	0.12
chr2_76655635_76655786	0.16	Pjvk	pejvakin	5437	0.16
chr1_43162619_43162984	0.16	Fhl2	four and a half LIM domains 2	1160	0.46
chr7_111691798_111691949	0.16	Galnt18	polypeptide N-acetylgalactosaminyltransferase 18	88104	0.09
chr12_16731274_16731620	0.16	Greb1	gene regulated by estrogen in breast cancer protein	8681	0.18
chr11_118034790_118034941	0.15	Pgs1	phosphatidylglycerophosphate synthase 1	22522	0.14
chr9_42097699_42097850	0.15	Sorl1	sortilin-related receptor, LDLR class A repeats-containing	26523	0.17
chr8_110933315_110933853	0.14	St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	1663	0.24
chr8_35410929_35411173	0.14	Gm45301	predicted gene 45301	1545	0.35
chr9_56572818_56573408	0.13	Gm47178	predicted gene, 47178	29357	0.13
chr1_180847897_180848799	0.13	Sde2	SDE2 telomere maintenance homolog (S. pombe)	2779	0.14
chr4_138219311_138219462	0.13	Hp1bp3	heterochromatin protein 1, binding protein 3	2092	0.2
chr5_140735262_140736522	0.13	Amz1	archaelysin family metallopeptidase 1	325	0.88
chr3_58162274_58162814	0.13	1700007F19Rik	RIKEN cDNA 1700007F19 gene	1263	0.35
chr9_84090334_84090732	0.13	Bckdhb	branched chain ketoacid dehydrogenase E1, beta polypeptide	16974	0.22
chr15_76207208_76209116	0.13	Plec	plectin	91	0.92
chr17_64469558_64469919	0.12	Mir6420	microRNA 6420	28932	0.22
chr16_87681170_87681353	0.12	Bach1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	17684	0.2
chr10_44476893_44477182	0.12	Prdm1	PR domain containing 1, with ZNF domain	18289	0.18
chr18_3279746_3279934	0.11	Crem	cAMP responsive element modulator	1238	0.52
chr14_48133184_48133904	0.11	Gm49310	predicted gene, 49310	680	0.61
chr7_128612386_128612537	0.11	Inpp5f	inositol polyphosphate-5-phosphatase F	1101	0.39
chr17_29321890_29323144	0.10	Gm46603	predicted gene, 46603	32	0.95
chr2_133556756_133557496	0.09	Bmp2	bone morphogenetic protein 2	4967	0.21
chr10_12996822_12997284	0.09	Sf3b5	splicing factor 3b, subunit 5	8290	0.19
chr6_36819200_36819780	0.09	Ptn	pleiotrophin	9270	0.28
chr16_38714001_38714161	0.08	Arhgap31	Rho GTPase activating protein 31	807	0.56
chr4_47437269_47438175	0.08	Gm12430	predicted gene 12430	15910	0.18
chr11_95580318_95580469	0.08	Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	7342	0.17
chr9_64734273_64734844	0.08	Rab11a	RAB11A, member RAS oncogene family	1953	0.32
chr2_166081092_166081487	0.08	Sulf2	sulfatase 2	3170	0.24
chr4_129331767_129331965	0.08	Rbbp4	retinoblastoma binding protein 4, chromatin remodeling factor	2778	0.16
chr5_77406870_77407021	0.07	Igfbp7	insulin-like growth factor binding protein 7	1095	0.43
chr12_112588763_112589606	0.07	Inf2	inverted formin, FH2 and WH2 domain containing	82	0.96
chr11_87737570_87738432	0.07	Supt4a	SPT4A, DSIF elongation factor subunit	448	0.66
chr6_126532364_126532878	0.07	Kcna5	potassium voltage-gated channel, shaker-related subfamily, member 5	2791	0.26
chr4_41724852_41725139	0.07	Dctn3	dynactin 3	1825	0.18
chr11_98202836_98204568	0.07	Cdk12	cyclin-dependent kinase 12	367	0.78
chr9_106885777_106887024	0.07	Rbm15b	RNA binding motif protein 15B	781	0.48
chr5_25705265_25705879	0.07	Xrcc2	X-ray repair complementing defective repair in Chinese hamster cells 2	192	0.92
chr3_60529662_60530216	0.07	Mbnl1	muscleblind like splicing factor 1	308	0.91
chr3_66985349_66986398	0.07	Rsrc1	arginine/serine-rich coiled-coil 1	94	0.97
chr11_108145810_108146207	0.06	Gm11655	predicted gene 11655	35842	0.19
chr1_66944417_66944813	0.06	Myl1	myosin, light polypeptide 1	528	0.7
chr10_80085003_80085473	0.06	Sbno2	strawberry notch 2	9799	0.09
chrX_134717661_134719186	0.06	Armcx1	armadillo repeat containing, X-linked 1	403	0.72
chr7_49778971_49779409	0.06	Prmt3	protein arginine N-methyltransferase 3	646	0.74
chr5_131697484_131697635	0.06	Gm42442	predicted gene 42442	794	0.53
chr8_106054482_106054922	0.06	Nfatc3	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3	4138	0.12
chr19_28677931_28680368	0.06	Glis3	GLIS family zinc finger 3	459	0.68
chr13_13953757_13954320	0.06	B3galnt2	UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2	431	0.62
chr2_68466086_68466372	0.05	Stk39	serine/threonine kinase 39	5711	0.21
chr17_5831890_5832283	0.05	Gm26622	predicted gene, 26622	5882	0.15
chr9_77939183_77940182	0.05	Elovl5	ELOVL family member 5, elongation of long chain fatty acids (yeast)	1609	0.32
chr11_110881943_110882098	0.05	Kcnj16	potassium inwardly-rectifying channel, subfamily J, member 16	86013	0.1
chr5_124262016_124262210	0.05	Mphosph9	M-phase phosphoprotein 9	899	0.42
chr4_116558201_116558717	0.05	Gpbp1l1	GC-rich promoter binding protein 1-like 1	380	0.75
chr18_77766808_77767753	0.05	Haus1	HAUS augmin-like complex, subunit 1	500	0.72
chr13_27325128_27325279	0.04	Gm11358	predicted gene 11358	6225	0.11
chr2_157423895_157425112	0.04	Src	Rous sarcoma oncogene	111	0.97
chr11_106329400_106329556	0.04	Cd79b	CD79B antigen	14716	0.1
chr13_104226999_104227150	0.03	Cenpk	centromere protein K	1537	0.29
chr7_25755347_25756122	0.03	Hnrnpul1	heterogeneous nuclear ribonucleoprotein U-like 1	977	0.37
chr7_99590707_99590917	0.03	Arrb1	arrestin, beta 1	3781	0.14
chr16_13545827_13545978	0.03	Gm25276	predicted gene, 25276	14351	0.15
chr1_180726093_180726901	0.03	Acbd3	acyl-Coenzyme A binding domain containing 3	454	0.72
chr13_83603651_83603866	0.03	Mef2c	myocyte enhancer factor 2C	21845	0.22
chrX_73483606_73484999	0.03	Bgn	biglycan	663	0.59
chr10_116871781_116872422	0.02	Myrfl	myelin regulatory factor-like	24818	0.15
chr4_131829238_131829510	0.02	Ptpru	protein tyrosine phosphatase, receptor type, U	7858	0.15
chr11_65421515_65421666	0.02	Gm12295	predicted gene 12295	55792	0.15
chr7_90447549_90447852	0.02	Crebzf	CREB/ATF bZIP transcription factor	2997	0.17
chrX_100782647_100782805	0.02	Dlg3	discs large MAGUK scaffold protein 3	5441	0.19
chr4_134453606_134454237	0.01	1700021N21Rik	RIKEN cDNA 1700021N21 gene	3750	0.13
chr10_61898411_61898967	0.01	Col13a1	collagen, type XIII, alpha 1	20297	0.19
chr6_57531398_57531878	0.01	Ppm1k	protein phosphatase 1K (PP2C domain containing)	3788	0.19
chr4_106827556_106828820	0.01	Gm12746	predicted gene 12746	19732	0.15
chr8_95804942_95805303	0.01	4930513N10Rik	RIKEN cDNA 4930513N10 gene	1622	0.19
chr16_13546060_13546211	0.01	Gm25276	predicted gene, 25276	14584	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp410

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.7	GO:0072553	terminal button organization(GO:0072553)
0.3	1.9	GO:1901678	iron coordination entity transport(GO:1901678)
0.1	2.2	GO:0043968	histone H2A acetylation(GO:0043968)
0.1	0.8	GO:0045629	negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1	0.9	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.1	0.5	GO:1902947	regulation of tau-protein kinase activity(GO:1902947)
0.1	1.4	GO:0032793	positive regulation of CREB transcription factor activity(GO:0032793)
0.1	0.3	GO:0043133	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.1	0.2	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1	0.4	GO:1904469	positive regulation of tumor necrosis factor secretion(GO:1904469)
0.1	0.4	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.1	0.3	GO:0045054	constitutive secretory pathway(GO:0045054)
0.1	0.4	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
0.1	0.2	GO:1903423	positive regulation of synaptic vesicle recycling(GO:1903423)
0.1	0.8	GO:2001223	negative regulation of neuron migration(GO:2001223)
0.1	0.6	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1	0.1	GO:1904339	negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.1	0.4	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.1	0.2	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1	0.3	GO:0002741	positive regulation of cytokine secretion involved in immune response(GO:0002741)
0.1	1.3	GO:0033014	porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.1	0.4	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.7	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.3	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	1.2	GO:0048240	sperm capacitation(GO:0048240)
0.0	0.5	GO:0018342	protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0	0.5	GO:0018119	peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.1	GO:2000974	negative regulation of pro-B cell differentiation(GO:2000974)
0.0	0.6	GO:0097320	membrane tubulation(GO:0097320)
0.0	0.2	GO:0002584	negative regulation of antigen processing and presentation of peptide antigen(GO:0002584)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.1	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.7	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.1	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	0.1	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0	0.1	GO:1905206	positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0	0.2	GO:0071763	nuclear membrane organization(GO:0071763)
0.0	0.1	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.1	GO:0003221	right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.0	0.1	GO:2000823	regulation of androgen receptor activity(GO:2000823)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.2	GO:0000338	protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0	0.1	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0	0.5	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	1.0	GO:1902653	cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.3	GO:0016926	protein desumoylation(GO:0016926)
0.0	0.1	GO:0003228	atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0	0.1	GO:0007060	male meiosis chromosome segregation(GO:0007060)
0.0	0.2	GO:0070862	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0	0.1	GO:0021569	rhombomere 3 development(GO:0021569)
0.0	0.1	GO:0006114	glycerol biosynthetic process(GO:0006114)
0.0	0.2	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0010159	specification of organ position(GO:0010159)
0.0	0.1	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902)
0.0	0.4	GO:0042730	fibrinolysis(GO:0042730)
0.0	0.2	GO:0035493	SNARE complex assembly(GO:0035493)
0.0	0.1	GO:0075509	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.5	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.1	GO:2000525	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0	0.0	GO:0002125	maternal aggressive behavior(GO:0002125)
0.0	0.1	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.0	GO:2000359	regulation of binding of sperm to zona pellucida(GO:2000359)
0.0	0.0	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.0	0.1	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128)
0.0	0.1	GO:0045448	regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.0	0.0	GO:0032439	endosome localization(GO:0032439)
0.0	0.2	GO:0045072	regulation of interferon-gamma biosynthetic process(GO:0045072) positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.2	GO:0051457	maintenance of protein location in nucleus(GO:0051457)
0.0	0.1	GO:0035898	parathyroid hormone secretion(GO:0035898)
0.0	0.0	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.0	GO:0046208	spermine catabolic process(GO:0046208)
0.0	0.1	GO:2000467	positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0	0.1	GO:0019054	modulation by virus of host process(GO:0019054)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.0	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.1	GO:0032437	cuticular plate(GO:0032437)
0.1	0.5	GO:0097452	GAIT complex(GO:0097452)
0.1	2.2	GO:0035267	NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1	0.4	GO:1990131	EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1	0.9	GO:0043020	NADPH oxidase complex(GO:0043020)
0.1	0.8	GO:0044327	dendritic spine head(GO:0044327)
0.1	1.7	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1	0.4	GO:0000796	condensin complex(GO:0000796)
0.1	0.3	GO:0032585	multivesicular body membrane(GO:0032585)
0.1	0.3	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.2	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.6	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.2	GO:0070820	tertiary granule(GO:0070820)
0.0	0.1	GO:0032010	phagolysosome(GO:0032010)
0.0	0.1	GO:0005712	chiasma(GO:0005712)
0.0	0.2	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.3	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.5	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0005859	muscle myosin complex(GO:0005859)
0.0	0.9	GO:0000123	histone acetyltransferase complex(GO:0000123)
0.0	0.2	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	0.5	GO:0008023	transcription elongation factor complex(GO:0008023)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0002079	inner acrosomal membrane(GO:0002079)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	1.2	GO:0001669	acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2	1.0	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1	0.7	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.1	0.9	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1	1.7	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.1	0.5	GO:0008318	protein prenyltransferase activity(GO:0008318)
0.1	0.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.1	0.2	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0	0.1	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.1	GO:0008260	3-oxoacid CoA-transferase activity(GO:0008260)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	1.2	GO:0016504	peptidase activator activity(GO:0016504)
0.0	0.1	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.1	GO:0035939	microsatellite binding(GO:0035939)
0.0	0.6	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.6	GO:1990003	phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.0	0.1	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0	0.3	GO:0016929	SUMO-specific protease activity(GO:0016929)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.4	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.3	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0	0.1	GO:0032407	MutSalpha complex binding(GO:0032407)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.4	GO:0031489	myosin V binding(GO:0031489)
0.0	0.9	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.5	GO:0042056	chemoattractant activity(GO:0042056)
0.0	0.0	GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0	0.2	GO:0051787	misfolded protein binding(GO:0051787)
0.0	1.8	GO:0002020	protease binding(GO:0002020)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0031893	vasopressin receptor binding(GO:0031893)
0.0	0.1	GO:0033592	RNA strand annealing activity(GO:0033592)
0.0	0.1	GO:0010853	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0	0.0	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.1	GO:0035613	RNA stem-loop binding(GO:0035613)
0.0	0.0	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.1	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	1.0	GO:0052735	rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.0	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.0	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.2	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.3	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.0	0.4	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.0	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0	0.4	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.2	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.0	0.0	GO:0019198	transmembrane receptor protein phosphatase activity(GO:0019198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.8	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.7	PID NECTIN PATHWAY	Nectin adhesion pathway
0.8	PID BMP PATHWAY	BMP receptor signaling
0.5	PID ARF6 PATHWAY	Arf6 signaling events
0.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.7	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.2	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.4	PID AURORA B PATHWAY	Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.5	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	1.0	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.3	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.8	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.6	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.7	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	1.1	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.3	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins