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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for AR_NR3C2

Z-value: 1.48

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Transcription factors associated with AR_NR3C2

Gene Symbol	Gene ID	Gene Info
AR Ensembl NCBI GeneCards UniProt	ENSG00000169083.11	AR
NR3C2 Ensembl NCBI GeneCards UniProt	ENSG00000151623.10	NR3C2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
AR	chrX_66915365_66915591	126747	0.062179	0.86	2.7e-03	Click!
AR	chrX_66946272_66946453	157631	0.042980	-0.75	2.1e-02	Click!
AR	chrX_66955172_66955323	166516	0.039019	-0.66	5.5e-02	Click!
AR	chrX_67004998_67005149	216342	0.024177	-0.65	5.6e-02	Click!
AR	chrX_67000391_67000546	211737	0.025171	0.62	7.5e-02	Click!
NR3C2	chr4_149276556_149276707	81381	0.112390	-0.82	6.3e-03	Click!
NR3C2	chr4_149229242_149229393	128695	0.056491	-0.79	1.2e-02	Click!
NR3C2	chr4_149350438_149350589	7499	0.323590	-0.77	1.5e-02	Click!
NR3C2	chr4_149353611_149353762	4326	0.357265	-0.73	2.7e-02	Click!
NR3C2	chr4_149298361_149298512	59576	0.160340	-0.71	3.1e-02	Click!

Activity of the AR_NR3C2 motif across conditions

Conditions sorted by the z-value of the AR_NR3C2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_100004430_100004581	1.32	CCDC85C	coiled-coil domain containing 85C	2080	0.29
chr2_19848269_19848420	1.10	TTC32	tetratricopeptide repeat domain 32	253058	0.02
chr1_66932158_66932309	1.07	SGIP1	SH3-domain GRB2-like (endophilin) interacting protein 1	66833	0.12
chr18_34021656_34021807	1.06	FHOD3	formin homology 2 domain containing 3	102783	0.08
chr15_63045655_63045939	1.05	TLN2	talin 2	4992	0.22
chr2_3474011_3474213	1.00	TRAPPC12	trafficking protein particle complex 12	4668	0.18
chr6_141179242_141179445	0.99	ENSG00000264390	.	174392	0.04
chr12_27900681_27900869	0.99	ENSG00000252585	.	5032	0.13
chr10_30236708_30236859	0.96	KIAA1462	KIAA1462	111670	0.07
chr1_22196645_22196796	0.95	HSPG2	heparan sulfate proteoglycan 2	4479	0.22
chr2_48710705_48710856	0.95	ENSG00000202227	.	18383	0.18
chr20_34685745_34686271	0.95	EPB41L1	erythrocyte membrane protein band 4.1-like 1	5249	0.2
chr10_30235923_30236074	0.94	KIAA1462	KIAA1462	112455	0.07
chr11_12434149_12434300	0.94	PARVA	parvin, alpha	14436	0.24
chr1_244512198_244512349	0.92	C1orf100	chromosome 1 open reading frame 100	3664	0.3
chr4_184558613_184558764	0.90	ENSG00000252157	.	16141	0.14
chr20_56592771_56592922	0.90	ENSG00000221451	.	41772	0.15
chr3_48731676_48731827	0.89	IP6K2	inositol hexakisphosphate kinase 2	1264	0.31
chr2_145769885_145770036	0.88	ENSG00000253036	.	322678	0.01
chr19_3336838_3336989	0.85	NFIC	nuclear factor I/C (CCAAT-binding transcription factor)	22648	0.15
chr8_102458007_102458158	0.85	GRHL2	grainyhead-like 2 (Drosophila)	46578	0.13
chr16_57687826_57687988	0.85	GPR56	G protein-coupled receptor 56	764	0.56
chr1_180827525_180827764	0.85	ENSG00000266825	.	30516	0.17
chr4_57594846_57594997	0.85	HOPX	HOP homeobox	46856	0.13
chr18_45856611_45856862	0.84	ZBTB7C	zinc finger and BTB domain containing 7C	8026	0.26
chr2_47063884_47064035	0.83	AC016722.3		16676	0.14
chr1_109371861_109372012	0.82	AKNAD1	AKNA domain containing 1	23403	0.15
chr6_161724528_161724679	0.80	AGPAT4	1-acylglycerol-3-phosphate O-acyltransferase 4	29510	0.26
chr3_53184032_53184571	0.80	PRKCD	protein kinase C, delta	5724	0.19
chr1_167766173_167766370	0.80	RP1-313L4.3		23373	0.19
chr20_4151764_4151915	0.79	SMOX	spermine oxidase	518	0.81
chr17_46561232_46561443	0.79	ENSG00000206805	.	4878	0.14
chr20_45543740_45543891	0.78	EYA2	eyes absent homolog 2 (Drosophila)	20552	0.22
chr3_40158038_40158189	0.77	MYRIP	myosin VIIA and Rab interacting protein	16611	0.25
chr17_43170864_43171027	0.76	PLCD3	phospholipase C, delta 3	19971	0.1
chr2_241190811_241190962	0.76	ENSG00000221412	.	10391	0.24
chr7_143209652_143209944	0.76	TAS2R41	taste receptor, type 2, member 41	34832	0.12
chr14_93439391_93439542	0.76	CHGA	chromogranin A (parathyroid secretory protein 1)	49945	0.14
chr1_223888318_223888469	0.76	CAPN2	calpain 2, (m/II) large subunit	902	0.61
chr10_74877735_74877886	0.75	RP11-152N13.16		7353	0.1
chr12_13331696_13332290	0.73	EMP1	epithelial membrane protein 1	17657	0.23
chr3_99640879_99641030	0.72	ENSG00000264897	.	42288	0.16
chr2_33383859_33384010	0.72	LTBP1	latent transforming growth factor beta binding protein 1	24210	0.25
chr4_24913711_24913879	0.72	CCDC149	coiled-coil domain containing 149	713	0.79
chr1_11219246_11219397	0.71	ENSG00000253086	.	6914	0.12
chr6_86173389_86173540	0.71	NT5E	5'-nucleotidase, ecto (CD73)	7635	0.28
chr2_28021942_28022093	0.70	AC110084.1		12831	0.16
chr8_56861171_56861322	0.70	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	8453	0.16
chr8_124562734_124562885	0.70	FBXO32	F-box protein 32	9363	0.2
chr10_13881950_13882101	0.69	FRMD4A	FERM domain containing 4A	18887	0.22
chr2_238787700_238787851	0.69	ENSG00000263723	.	9228	0.2
chr17_15866796_15866947	0.69	ADORA2B	adenosine A2b receptor	18640	0.15
chr5_150159787_150160102	0.69	AC010441.1		2077	0.24
chr6_155593510_155593784	0.69	CLDN20	claudin 20	8500	0.2
chr14_55925449_55925600	0.69	TBPL2	TATA box binding protein like 2	2080	0.38
chr9_3863683_3863834	0.68	RP11-252M18.3		11826	0.25
chr6_151357426_151357577	0.68	MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	609	0.72
chr12_26441077_26441474	0.68	RP11-283G6.5		16422	0.18
chr21_39612976_39613250	0.68	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	15550	0.24
chr13_110161938_110162089	0.67	LINC00676	long intergenic non-protein coding RNA 676	218616	0.02
chr4_170129389_170129540	0.67	RP11-327O17.2		6519	0.28
chr9_130447197_130447348	0.67	ENSG00000264329	.	5802	0.13
chr4_169717957_169718108	0.67	PALLD	palladin, cytoskeletal associated protein	35124	0.16
chr6_43636660_43636811	0.66	MRPS18A	mitochondrial ribosomal protein S18A	18793	0.12
chr7_75678596_75678833	0.66	MDH2	malate dehydrogenase 2, NAD (mitochondrial)	1235	0.32
chr5_149878333_149878560	0.65	NDST1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	957	0.56
chr4_41062724_41062875	0.65	ENSG00000199790	.	23825	0.18
chr4_6993000_6993535	0.65	AC097382.5		3801	0.14
chr1_201886871_201887022	0.65	RP11-307B6.3		19718	0.1
chr11_95254135_95254332	0.64	ENSG00000201204	.	47695	0.19
chr5_131604535_131604686	0.64	PDLIM4	PDZ and LIM domain 4	7468	0.16
chr3_156534966_156535117	0.64	LEKR1	leucine, glutamate and lysine rich 1	9048	0.29
chr16_50237563_50237763	0.64	ADCY7	adenylate cyclase 7	42385	0.12
chr5_95674311_95674759	0.64	PCSK1	proprotein convertase subtilisin/kexin type 1	93329	0.08
chr10_34873395_34873546	0.64	PARD3	par-3 family cell polarity regulator	157811	0.04
chr13_109609770_109610065	0.64	MYO16	myosin XVI	71400	0.13
chr5_95401493_95401712	0.63	ENSG00000207578	.	13240	0.25
chr3_73085736_73086140	0.63	ENSG00000238959	.	8979	0.16
chr16_9142329_9142480	0.63	C16orf72	chromosome 16 open reading frame 72	43101	0.12
chr22_24980060_24980211	0.63	GGT1	gamma-glutamyltransferase 1	417	0.78
chr12_3309876_3310419	0.63	TSPAN9	tetraspanin 9	194	0.96
chr17_79039549_79039700	0.63	BAIAP2	BAI1-associated protein 2	8090	0.13
chr5_157810174_157810325	0.63	ENSG00000222626	.	406285	0.01
chr21_36696632_36696783	0.62	RUNX1	runt-related transcription factor 1	275066	0.01
chr15_42694918_42695069	0.62	CAPN3	calpain 3, (p94)	4	0.97
chr18_46260220_46260632	0.62	RP11-426J5.2		45636	0.16
chr21_30518493_30518644	0.62	ENSG00000201984	.	6863	0.14
chr2_102680238_102680787	0.61	IL1R1	interleukin 1 receptor, type I	492	0.85
chr22_50969649_50969871	0.61	ODF3B	outer dense fiber of sperm tails 3B	746	0.33
chr5_119789870_119790021	0.61	PRR16	proline rich 16	10028	0.31
chr9_15735715_15735866	0.61	CCDC171	coiled-coil domain containing 171	8713	0.26
chr2_15310055_15310206	0.60	NBAS	neuroblastoma amplified sequence	20391	0.29
chr1_198202205_198202356	0.60	NEK7	NIMA-related kinase 7	12351	0.31
chr6_15504791_15504942	0.60	DTNBP1	dystrobrevin binding protein 1	43727	0.19
chr13_94962334_94962485	0.60	GPC6-AS1	GPC6 antisense RNA 1	122164	0.06
chr4_145621362_145621513	0.59	HHIP-AS1	HHIP antisense RNA 1	38928	0.19
chr2_46542548_46542756	0.59	EPAS1	endothelial PAS domain protein 1	18111	0.25
chr2_36681200_36681351	0.59	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	59558	0.12
chr12_46887776_46887927	0.58	SLC38A2	solute carrier family 38, member 2	121201	0.06
chr13_30700064_30700215	0.58	ENSG00000266816	.	80697	0.11
chr8_13282364_13282515	0.58	DLC1	deleted in liver cancer 1	74311	0.1
chr8_96812845_96812996	0.58	ENSG00000223297	.	121777	0.06
chr4_86954278_86954588	0.57	RP13-514E23.1		19406	0.19
chr22_27501498_27501649	0.57	ENSG00000200443	.	69723	0.14
chr8_67472226_67472377	0.57	MYBL1	v-myb avian myeloblastosis viral oncogene homolog-like 1	52841	0.1
chr22_47426182_47426436	0.57	ENSG00000221672	.	182506	0.03
chr8_120126669_120126820	0.57	RP11-278I4.2		45723	0.15
chr1_205335200_205335351	0.57	LEMD1-AS1	LEMD1 antisense RNA 1	7105	0.17
chr7_40261588_40261739	0.57	SUGCT	succinylCoA:glutarate-CoA transferase	87044	0.09
chr6_155850479_155850743	0.57	NOX3	NADPH oxidase 3	73574	0.12
chr1_183117616_183117767	0.56	RP11-181K3.4		7274	0.22
chr12_53443486_53443637	0.56	TENC1	tensin like C1 domain containing phosphatase (tensin 2)	119	0.93
chr2_232539358_232539509	0.56	ENSG00000239202	.	28449	0.13
chr4_177704261_177704412	0.56	VEGFC	vascular endothelial growth factor C	9545	0.31
chr11_12221922_12222073	0.56	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	38294	0.17
chr9_38682670_38682821	0.56	ENSG00000252725	.	2742	0.34
chr15_31676742_31676893	0.55	KLF13	Kruppel-like factor 13	18460	0.28
chr22_30175136_30175287	0.55	UQCR10	ubiquinol-cytochrome c reductase, complex III subunit X	11848	0.12
chr10_80831884_80832062	0.55	ZMIZ1	zinc finger, MIZ-type containing 1	3181	0.3
chr4_20268163_20268314	0.55	SLIT2	slit homolog 2 (Drosophila)	11695	0.31
chr1_44249696_44249884	0.55	ST3GAL3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	47856	0.11
chr1_214741452_214741603	0.55	PTPN14	protein tyrosine phosphatase, non-receptor type 14	16961	0.24
chr3_12960579_12960730	0.55	IQSEC1	IQ motif and Sec7 domain 1	48514	0.12
chr8_62602534_62602708	0.55	ASPH	aspartate beta-hydroxylase	213	0.95
chr20_34457569_34457720	0.55	ENSG00000199676	.	16358	0.13
chr8_126496676_126496827	0.55	ENSG00000266452	.	39944	0.18
chr14_56800333_56800607	0.55	TMEM260	transmembrane protein 260	154602	0.04
chr5_54207045_54207196	0.54	RP11-45H22.3	Uncharacterized protein	46554	0.13
chr6_5125637_5125928	0.54	ENSG00000265083	.	22774	0.19
chr20_50248125_50248545	0.54	NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	68965	0.12
chr5_148346010_148346161	0.54	RP11-44B19.1		3818	0.26
chr2_74787629_74787875	0.54	LOXL3	lysyl oxidase-like 3	4935	0.1
chr1_117690445_117690596	0.54	TRIM45	tripartite motif containing 45	25311	0.15
chr9_97563146_97563297	0.54	C9orf3	chromosome 9 open reading frame 3	763	0.65
chr19_2543854_2544412	0.54	ENSG00000252962	.	40994	0.11
chr5_148515097_148515248	0.53	ABLIM3	actin binding LIM protein family, member 3	5874	0.19
chr10_14519559_14519710	0.53	FRMD4A	FERM domain containing 4A	15493	0.21
chr17_13447545_13447833	0.52	ENSG00000221698	.	726	0.71
chr8_128403450_128403601	0.52	POU5F1B	POU class 5 homeobox 1B	23010	0.23
chr17_62660365_62660516	0.52	SMURF2	SMAD specific E3 ubiquitin protein ligase 2	2254	0.34
chr18_26734289_26734440	0.52	ENSG00000212085	.	42128	0.18
chr22_36181419_36181847	0.52	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	7554	0.27
chr20_33166516_33166667	0.51	MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	20069	0.16
chr7_23470661_23470850	0.51	ENSG00000252590	.	19522	0.16
chr20_33895079_33895258	0.51	FAM83C	family with sequence similarity 83, member C	14964	0.1
chr22_44453249_44453400	0.51	PARVB	parvin, beta	11617	0.25
chr5_67289012_67289163	0.51	ENSG00000223149	.	25814	0.26
chr15_101717639_101717898	0.50	CHSY1	chondroitin sulfate synthase 1	74369	0.09
chr1_222164593_222164744	0.50	ENSG00000212094	.	21764	0.28
chr20_22775413_22775564	0.50	ENSG00000265151	.	61549	0.14
chr16_67951318_67951477	0.50	CTRL	chymotrypsin-like	14368	0.08
chr2_173290792_173290943	0.50	ITGA6	integrin, alpha 6	1215	0.44
chr11_61463037_61463336	0.50	DAGLA	diacylglycerol lipase, alpha	15281	0.16
chr3_69811903_69812159	0.50	MITF	microphthalmia-associated transcription factor	156	0.97
chr8_117702787_117702938	0.50	EIF3H	eukaryotic translation initiation factor 3, subunit H	65161	0.12
chr1_19271200_19271351	0.49	IFFO2	intermediate filament family orphan 2	10917	0.19
chr8_124281675_124281846	0.49	ZHX1-C8ORF76	ZHX1-C8ORF76 readthrough	2133	0.17
chr11_110668037_110668323	0.49	ARHGAP20	Rho GTPase activating protein 20	84268	0.11
chr6_135174576_135174727	0.49	ALDH8A1	aldehyde dehydrogenase 8 family, member A1	75648	0.11
chr15_49069969_49070120	0.48	RP11-485O10.2		5343	0.21
chr1_192499348_192499877	0.48	RP5-1011O1.2		36735	0.16
chr7_7593210_7593361	0.48	MIOS	missing oocyte, meiosis regulator, homolog (Drosophila)	13218	0.22
chr8_127833738_127833889	0.48	ENSG00000212451	.	150046	0.04
chr15_49073804_49073955	0.48	RP11-485O10.2		1508	0.4
chr7_42717076_42717227	0.48	C7orf25	chromosome 7 open reading frame 25	234358	0.02
chr1_115723224_115723375	0.47	TSPAN2	tetraspanin 2	91178	0.08
chr19_43954759_43955038	0.47	LYPD3	LY6/PLAUR domain containing 3	14914	0.13
chr4_148703798_148703949	0.47	ENSG00000264274	.	127	0.96
chr1_21024911_21025062	0.47	KIF17	kinesin family member 17	18998	0.13
chr20_11176893_11177136	0.47	C20orf187	chromosome 20 open reading frame 187	168203	0.04
chr1_40423957_40424317	0.47	MFSD2A	major facilitator superfamily domain containing 2A	3315	0.2
chr7_134604064_134604215	0.47	CALD1	caldesmon 1	1098	0.63
chr7_29149222_29149373	0.47	CPVL	carboxypeptidase, vitellogenic-like	3240	0.22
chr15_74373495_74373794	0.47	GOLGA6A	golgin A6 family, member A	1247	0.38
chr20_23426178_23426329	0.47	CSTL1	cystatin-like 1	5368	0.13
chr10_5594332_5594536	0.47	CALML3-AS1	CALML3 antisense RNA 1	26225	0.13
chr19_612185_612336	0.46	AC005559.2		4899	0.1
chr13_21607464_21607818	0.46	ENSG00000201821	.	5165	0.17
chr12_54590925_54591203	0.46	SMUG1	single-strand-selective monofunctional uracil-DNA glycosylase 1	8286	0.12
chr10_133110720_133110871	0.46	TCERG1L	transcription elongation regulator 1-like	811	0.78
chr14_37466179_37466330	0.46	ENSG00000266327	.	44658	0.17
chr1_152141043_152141216	0.46	FLG-AS1	FLG antisense RNA 1	528	0.73
chr1_246020674_246020825	0.46	RP11-83A16.1		176104	0.03
chr3_141866576_141866846	0.46	TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)	1591	0.36
chr6_82543726_82543877	0.46	ENSG00000206886	.	70060	0.11
chr11_85453398_85453549	0.45	SYTL2	synaptotagmin-like 2	14402	0.19
chr9_42854346_42854549	0.45	AC129778.2		1845	0.47
chr14_68610729_68611179	0.45	ENSG00000244677	.	5671	0.25
chr1_31575614_31575797	0.45	PUM1	pumilio RNA-binding family member 1	36867	0.17
chr20_45947327_45947866	0.45	AL031666.2	HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852	350	0.82
chr17_47527935_47528264	0.45	ENSG00000207127	.	33887	0.1
chr2_47139549_47139700	0.45	MCFD2	multiple coagulation factor deficiency 2	1589	0.3
chr4_114390008_114390159	0.45	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	44915	0.14
chr13_38069587_38069738	0.45	POSTN	periostin, osteoblast specific factor	103201	0.08
chr8_95239241_95239392	0.45	CDH17	cadherin 17, LI cadherin (liver-intestine)	9785	0.24
chr9_69654789_69655001	0.44	AL445665.1	Protein LOC100996643	4632	0.3
chr19_41727336_41727487	0.44	CTD-2195B23.3		545	0.64
chr10_61942717_61942868	0.44	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	16138	0.27
chr7_2146247_2146398	0.44	MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	1021	0.66
chr9_67027339_67027528	0.44	ENSG00000265285	.	67500	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0008215	spermine metabolic process(GO:0008215)
0.1	0.5	GO:0071731	response to nitric oxide(GO:0071731)
0.1	0.3	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.1	0.2	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.1	0.2	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1	0.2	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.1	0.2	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.5	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.1	0.2	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.1	0.2	GO:0021831	embryonic olfactory bulb interneuron precursor migration(GO:0021831)
0.1	0.2	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.3	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.1	0.2	GO:0007501	mesodermal cell fate specification(GO:0007501)
0.1	0.6	GO:0007520	myoblast fusion(GO:0007520)
0.1	0.2	GO:1903224	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.2	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.2	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.2	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.2	GO:0002551	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.2	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0044557	relaxation of smooth muscle(GO:0044557) relaxation of vascular smooth muscle(GO:0060087)
0.0	0.2	GO:0030202	heparin metabolic process(GO:0030202)
0.0	0.1	GO:0097501	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.5	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0048840	otolith development(GO:0048840)
0.0	0.4	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.2	GO:0051155	positive regulation of striated muscle cell differentiation(GO:0051155)
0.0	0.6	GO:0045214	sarcomere organization(GO:0045214)
0.0	0.2	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.2	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.2	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.2	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.5	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.1	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.3	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.1	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.0	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.0	GO:0032226	positive regulation of synaptic transmission, dopaminergic(GO:0032226)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.3	GO:0007263	nitric oxide mediated signal transduction(GO:0007263)
0.0	0.1	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.1	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.0	GO:0061043	vascular wound healing(GO:0061042) regulation of vascular wound healing(GO:0061043)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.0	GO:0031065	regulation of histone deacetylation(GO:0031063) positive regulation of histone deacetylation(GO:0031065)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.1	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.2	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.1	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.1	GO:1904376	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.0	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.0	GO:0060744	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0	0.1	GO:0060055	angiogenesis involved in wound healing(GO:0060055)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	0.0	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.0	0.1	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.0	GO:2000696	nephron tubule epithelial cell differentiation(GO:0072160) regulation of nephron tubule epithelial cell differentiation(GO:0072182) regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
0.0	0.1	GO:0009223	pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0	0.1	GO:0090224	regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.0	0.0	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.1	GO:0051503	adenine nucleotide transport(GO:0051503)
0.0	0.0	GO:0048668	collateral sprouting(GO:0048668) regulation of collateral sprouting(GO:0048670)
0.0	0.1	GO:0000255	allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.1	GO:0043097	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.1	GO:0071636	positive regulation of transforming growth factor beta production(GO:0071636)
0.0	0.1	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.1	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.0	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.0	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.0	GO:1902305	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.1	GO:0060155	platelet dense granule organization(GO:0060155)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.0	GO:0051712	positive regulation of killing of cells of other organism(GO:0051712)
0.0	0.0	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.1	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.0	0.1	GO:0090103	cochlea morphogenesis(GO:0090103)
0.0	0.2	GO:0035338	long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0	0.1	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0006878	cellular copper ion homeostasis(GO:0006878)
0.0	0.3	GO:0051693	actin filament capping(GO:0051693)
0.0	0.0	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.2	GO:0016180	snRNA processing(GO:0016180)
0.0	0.1	GO:0034644	cellular response to UV(GO:0034644)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0045161	neuronal ion channel clustering(GO:0045161)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.0	GO:0046639	negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0	0.0	GO:0070527	platelet aggregation(GO:0070527)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.1	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.0	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.1	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.0	0.1	GO:0090398	cellular senescence(GO:0090398)
0.0	0.0	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.0	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.0	GO:0034653	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0045040	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.0	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0042921	glucocorticoid receptor signaling pathway(GO:0042921)
0.0	0.1	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.2	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.0	GO:0034393	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.1	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0016540	protein autoprocessing(GO:0016540)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.0	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.0	GO:0005997	xylulose metabolic process(GO:0005997)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.0	GO:0070254	mucus secretion(GO:0070254)
0.0	0.1	GO:0007435	salivary gland morphogenesis(GO:0007435)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.1	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.0	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.0	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.0	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0009437	amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.0	0.0	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.0	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.0	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.0	GO:0032060	bleb assembly(GO:0032060)
0.0	0.0	GO:0003148	outflow tract septum morphogenesis(GO:0003148)
0.0	0.0	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.0	GO:0050748	negative regulation of lipoprotein metabolic process(GO:0050748)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.0	GO:0016048	detection of temperature stimulus(GO:0016048)
0.0	0.1	GO:0007494	midgut development(GO:0007494)
0.0	0.1	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.1	GO:0001706	endoderm formation(GO:0001706)
0.0	0.9	GO:0007218	neuropeptide signaling pathway(GO:0007218)
0.0	0.1	GO:0046718	viral entry into host cell(GO:0046718)
0.0	0.0	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.0	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
0.0	0.0	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.0	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.0	GO:0021794	thalamus development(GO:0021794)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.2	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.2	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.2	GO:0005915	zonula adherens(GO:0005915)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.2	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.0	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0031082	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0	0.2	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.1	GO:0043256	laminin complex(GO:0043256)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.2	GO:0030914	STAGA complex(GO:0030914)
0.0	0.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.4	GO:0001750	photoreceptor outer segment(GO:0001750)
0.0	0.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.0	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.1	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.2	GO:0032039	integrator complex(GO:0032039)
0.0	0.2	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.2	GO:0034706	sodium channel complex(GO:0034706)
0.0	0.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.0	GO:0045277	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0	0.0	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.0	GO:0005638	lamin filament(GO:0005638)
0.0	0.2	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.0	0.2	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0070822	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1	0.5	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1	0.4	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1	0.4	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.1	0.2	GO:0004948	calcitonin receptor activity(GO:0004948)
0.1	0.9	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.5	GO:0003840	gamma-glutamyltransferase activity(GO:0003840)
0.1	0.2	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.5	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.3	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.2	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.2	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0015226	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.2	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.4	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.1	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.2	GO:0004312	fatty acid synthase activity(GO:0004312)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.1	GO:0004308	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.2	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.1	GO:0070513	death domain binding(GO:0070513)
0.0	0.1	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.0	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.0	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.4	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0	0.1	GO:0016615	malate dehydrogenase activity(GO:0016615)
0.0	0.1	GO:0070063	RNA polymerase binding(GO:0070063)
0.0	0.5	GO:0017137	Rab GTPase binding(GO:0017137)
0.0	0.1	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.0	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.0	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.2	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.1	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.0	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.1	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.0	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.3	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.0	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.0	GO:0000295	adenine nucleotide transmembrane transporter activity(GO:0000295) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0	0.0	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0047617	acyl-CoA hydrolase activity(GO:0047617)
0.0	0.2	GO:0005537	mannose binding(GO:0005537)
0.0	0.0	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.0	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.0	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.2	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.0	GO:0097506	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0	0.0	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.0	0.0	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0016411	acylglycerol O-acyltransferase activity(GO:0016411)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.0	GO:0016531	metallochaperone activity(GO:0016530) copper chaperone activity(GO:0016531)
0.0	0.2	GO:0017147	Wnt-protein binding(GO:0017147)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	0.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.0	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	0.2	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	0.5	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.0	0.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.4	PID AURORA A PATHWAY	Aurora A signaling
0.0	0.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.2	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.3	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.0	0.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	1.1	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.0	0.2	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.0	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	0.1	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	0.0	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.0	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.5	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.6	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.4	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.4	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.2	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.3	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.2	REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	Genes involved in MAPK targets/ Nuclear events mediated by MAP kinases
0.0	0.3	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.6	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.7	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.0	0.1	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.2	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation