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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for AR_NR3C2

Z-value: 1.48

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Transcription factors associated with AR_NR3C2

Gene Symbol Gene ID Gene Info
AR
ENSG00000169083.11 androgen receptor
NR3C2
ENSG00000151623.10 nuclear receptor subfamily 3 group C member 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chrX_66915365_66915591AR1267470.0621790.862.7e-03Click!
chrX_66946272_66946453AR1576310.042980-0.752.1e-02Click!
chrX_66955172_66955323AR1665160.039019-0.665.5e-02Click!
chrX_67004998_67005149AR2163420.024177-0.655.6e-02Click!
chrX_67000391_67000546AR2117370.0251710.627.5e-02Click!
chr4_149276556_149276707NR3C2813810.112390-0.826.3e-03Click!
chr4_149229242_149229393NR3C21286950.056491-0.791.2e-02Click!
chr4_149350438_149350589NR3C274990.323590-0.771.5e-02Click!
chr4_149353611_149353762NR3C243260.357265-0.732.7e-02Click!
chr4_149298361_149298512NR3C2595760.160340-0.713.1e-02Click!

Activity of the AR_NR3C2 motif across conditions

Conditions sorted by the z-value of the AR_NR3C2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr14_100004430_100004581 1.32 CCDC85C
 coiled-coil domain containing 85C
 2080
 0.29
chr2_19848269_19848420 1.10 TTC32
 tetratricopeptide repeat domain 32
 253058
 0.02
chr1_66932158_66932309 1.07 SGIP1
 SH3-domain GRB2-like (endophilin) interacting protein 1
 66833
 0.12
chr18_34021656_34021807 1.06 FHOD3
 formin homology 2 domain containing 3
 102783
 0.08
chr15_63045655_63045939 1.05 TLN2
 talin 2
 4992
 0.22
chr2_3474011_3474213 1.00 TRAPPC12
 trafficking protein particle complex 12
 4668
 0.18
chr6_141179242_141179445 0.99 ENSG00000264390
 .
 174392
 0.04
chr12_27900681_27900869 0.99 ENSG00000252585
 .
 5032
 0.13
chr10_30236708_30236859 0.96 KIAA1462
 KIAA1462
 111670
 0.07
chr1_22196645_22196796 0.95 HSPG2
 heparan sulfate proteoglycan 2
 4479
 0.22
chr2_48710705_48710856 0.95 ENSG00000202227
 .
 18383
 0.18
chr20_34685745_34686271 0.95 EPB41L1
 erythrocyte membrane protein band 4.1-like 1
 5249
 0.2
chr10_30235923_30236074 0.94 KIAA1462
 KIAA1462
 112455
 0.07
chr11_12434149_12434300 0.94 PARVA
 parvin, alpha
 14436
 0.24
chr1_244512198_244512349 0.92 C1orf100
 chromosome 1 open reading frame 100
 3664
 0.3
chr4_184558613_184558764 0.90 ENSG00000252157
 .
 16141
 0.14
chr20_56592771_56592922 0.90 ENSG00000221451
 .
 41772
 0.15
chr3_48731676_48731827 0.89 IP6K2
 inositol hexakisphosphate kinase 2
 1264
 0.31
chr2_145769885_145770036 0.88 ENSG00000253036
 .
 322678
 0.01
chr19_3336838_3336989 0.85 NFIC
 nuclear factor I/C (CCAAT-binding transcription factor)
 22648
 0.15
chr8_102458007_102458158 0.85 GRHL2
 grainyhead-like 2 (Drosophila)
 46578
 0.13
chr16_57687826_57687988 0.85 GPR56
 G protein-coupled receptor 56
 764
 0.56
chr1_180827525_180827764 0.85 ENSG00000266825
 .
 30516
 0.17
chr4_57594846_57594997 0.85 HOPX
 HOP homeobox
 46856
 0.13
chr18_45856611_45856862 0.84 ZBTB7C
 zinc finger and BTB domain containing 7C
 8026
 0.26
chr2_47063884_47064035 0.83 AC016722.3
16676
 0.14
chr1_109371861_109372012 0.82 AKNAD1
 AKNA domain containing 1
 23403
 0.15
chr6_161724528_161724679 0.80 AGPAT4
 1-acylglycerol-3-phosphate O-acyltransferase 4
 29510
 0.26
chr3_53184032_53184571 0.80 PRKCD
 protein kinase C, delta
 5724
 0.19
chr1_167766173_167766370 0.80 RP1-313L4.3
23373
 0.19
chr20_4151764_4151915 0.79 SMOX
 spermine oxidase
 518
 0.81
chr17_46561232_46561443 0.79 ENSG00000206805
 .
 4878
 0.14
chr20_45543740_45543891 0.78 EYA2
 eyes absent homolog 2 (Drosophila)
 20552
 0.22
chr3_40158038_40158189 0.77 MYRIP
 myosin VIIA and Rab interacting protein
 16611
 0.25
chr17_43170864_43171027 0.76 PLCD3
 phospholipase C, delta 3
 19971
 0.1
chr2_241190811_241190962 0.76 ENSG00000221412
 .
 10391
 0.24
chr7_143209652_143209944 0.76 TAS2R41
 taste receptor, type 2, member 41
 34832
 0.12
chr14_93439391_93439542 0.76 CHGA
 chromogranin A (parathyroid secretory protein 1)
 49945
 0.14
chr1_223888318_223888469 0.76 CAPN2
 calpain 2, (m/II) large subunit
 902
 0.61
chr10_74877735_74877886 0.75 RP11-152N13.16
7353
 0.1
chr12_13331696_13332290 0.73 EMP1
 epithelial membrane protein 1
 17657
 0.23
chr3_99640879_99641030 0.72 ENSG00000264897
 .
 42288
 0.16
chr2_33383859_33384010 0.72 LTBP1
 latent transforming growth factor beta binding protein 1
 24210
 0.25
chr4_24913711_24913879 0.72 CCDC149
 coiled-coil domain containing 149
 713
 0.79
chr1_11219246_11219397 0.71 ENSG00000253086
 .
 6914
 0.12
chr6_86173389_86173540 0.71 NT5E
 5'-nucleotidase, ecto (CD73)
 7635
 0.28
chr2_28021942_28022093 0.70 AC110084.1
12831
 0.16
chr8_56861171_56861322 0.70 LYN
 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
 8453
 0.16
chr8_124562734_124562885 0.70 FBXO32
 F-box protein 32
 9363
 0.2
chr10_13881950_13882101 0.69 FRMD4A
 FERM domain containing 4A
 18887
 0.22
chr2_238787700_238787851 0.69 ENSG00000263723
 .
 9228
 0.2
chr17_15866796_15866947 0.69 ADORA2B
 adenosine A2b receptor
 18640
 0.15
chr5_150159787_150160102 0.69 AC010441.1
2077
 0.24
chr6_155593510_155593784 0.69 CLDN20
 claudin 20
 8500
 0.2
chr14_55925449_55925600 0.69 TBPL2
 TATA box binding protein like 2
 2080
 0.38
chr9_3863683_3863834 0.68 RP11-252M18.3
11826
 0.25
chr6_151357426_151357577 0.68 MTHFD1L
 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
 609
 0.72
chr12_26441077_26441474 0.68 RP11-283G6.5
16422
 0.18
chr21_39612976_39613250 0.68 KCNJ15
 potassium inwardly-rectifying channel, subfamily J, member 15
 15550
 0.24
chr13_110161938_110162089 0.67 LINC00676
 long intergenic non-protein coding RNA 676
 218616
 0.02
chr4_170129389_170129540 0.67 RP11-327O17.2
6519
 0.28
chr9_130447197_130447348 0.67 ENSG00000264329
 .
 5802
 0.13
chr4_169717957_169718108 0.67 PALLD
 palladin, cytoskeletal associated protein
 35124
 0.16
chr6_43636660_43636811 0.66 MRPS18A
 mitochondrial ribosomal protein S18A
 18793
 0.12
chr7_75678596_75678833 0.66 MDH2
 malate dehydrogenase 2, NAD (mitochondrial)
 1235
 0.32
chr5_149878333_149878560 0.65 NDST1
 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
 957
 0.56
chr4_41062724_41062875 0.65 ENSG00000199790
 .
 23825
 0.18
chr4_6993000_6993535 0.65 AC097382.5
3801
 0.14
chr1_201886871_201887022 0.65 RP11-307B6.3
19718
 0.1
chr11_95254135_95254332 0.64 ENSG00000201204
 .
 47695
 0.19
chr5_131604535_131604686 0.64 PDLIM4
 PDZ and LIM domain 4
 7468
 0.16
chr3_156534966_156535117 0.64 LEKR1
 leucine, glutamate and lysine rich 1
 9048
 0.29
chr16_50237563_50237763 0.64 ADCY7
 adenylate cyclase 7
 42385
 0.12
chr5_95674311_95674759 0.64 PCSK1
 proprotein convertase subtilisin/kexin type 1
 93329
 0.08
chr10_34873395_34873546 0.64 PARD3
 par-3 family cell polarity regulator
 157811
 0.04
chr13_109609770_109610065 0.64 MYO16
 myosin XVI
 71400
 0.13
chr5_95401493_95401712 0.63 ENSG00000207578
 .
 13240
 0.25
chr3_73085736_73086140 0.63 ENSG00000238959
 .
 8979
 0.16
chr16_9142329_9142480 0.63 C16orf72
 chromosome 16 open reading frame 72
 43101
 0.12
chr22_24980060_24980211 0.63 GGT1
 gamma-glutamyltransferase 1
 417
 0.78
chr12_3309876_3310419 0.63 TSPAN9
 tetraspanin 9
 194
 0.96
chr17_79039549_79039700 0.63 BAIAP2
 BAI1-associated protein 2
 8090
 0.13
chr5_157810174_157810325 0.63 ENSG00000222626
 .
 406285
 0.01
chr21_36696632_36696783 0.62 RUNX1
 runt-related transcription factor 1
 275066
 0.01
chr15_42694918_42695069 0.62 CAPN3
 calpain 3, (p94)
 4
 0.97
chr18_46260220_46260632 0.62 RP11-426J5.2
45636
 0.16
chr21_30518493_30518644 0.62 ENSG00000201984
 .
 6863
 0.14
chr2_102680238_102680787 0.61 IL1R1
 interleukin 1 receptor, type I
 492
 0.85
chr22_50969649_50969871 0.61 ODF3B
 outer dense fiber of sperm tails 3B
 746
 0.33
chr5_119789870_119790021 0.61 PRR16
 proline rich 16
 10028
 0.31
chr9_15735715_15735866 0.61 CCDC171
 coiled-coil domain containing 171
 8713
 0.26
chr2_15310055_15310206 0.60 NBAS
 neuroblastoma amplified sequence
 20391
 0.29
chr1_198202205_198202356 0.60 NEK7
 NIMA-related kinase 7
 12351
 0.31
chr6_15504791_15504942 0.60 DTNBP1
 dystrobrevin binding protein 1
 43727
 0.19
chr13_94962334_94962485 0.60 GPC6-AS1
 GPC6 antisense RNA 1
 122164
 0.06
chr4_145621362_145621513 0.59 HHIP-AS1
 HHIP antisense RNA 1
 38928
 0.19
chr2_46542548_46542756 0.59 EPAS1
 endothelial PAS domain protein 1
 18111
 0.25
chr2_36681200_36681351 0.59 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 59558
 0.12
chr12_46887776_46887927 0.58 SLC38A2
 solute carrier family 38, member 2
 121201
 0.06
chr13_30700064_30700215 0.58 ENSG00000266816
 .
 80697
 0.11
chr8_13282364_13282515 0.58 DLC1
 deleted in liver cancer 1
 74311
 0.1
chr8_96812845_96812996 0.58 ENSG00000223297
 .
 121777
 0.06
chr4_86954278_86954588 0.57 RP13-514E23.1
19406
 0.19
chr22_27501498_27501649 0.57 ENSG00000200443
 .
 69723
 0.14
chr8_67472226_67472377 0.57 MYBL1
 v-myb avian myeloblastosis viral oncogene homolog-like 1
 52841
 0.1
chr22_47426182_47426436 0.57 ENSG00000221672
 .
 182506
 0.03
chr8_120126669_120126820 0.57 RP11-278I4.2
45723
 0.15
chr1_205335200_205335351 0.57 LEMD1-AS1
 LEMD1 antisense RNA 1
 7105
 0.17
chr7_40261588_40261739 0.57 SUGCT
 succinylCoA:glutarate-CoA transferase
 87044
 0.09
chr6_155850479_155850743 0.57 NOX3
 NADPH oxidase 3
 73574
 0.12
chr1_183117616_183117767 0.56 RP11-181K3.4
7274
 0.22
chr12_53443486_53443637 0.56 TENC1
 tensin like C1 domain containing phosphatase (tensin 2)
 119
 0.93
chr2_232539358_232539509 0.56 ENSG00000239202
 .
 28449
 0.13
chr4_177704261_177704412 0.56 VEGFC
 vascular endothelial growth factor C
 9545
 0.31
chr11_12221922_12222073 0.56 MICAL2
 microtubule associated monooxygenase, calponin and LIM domain containing 2
 38294
 0.17
chr9_38682670_38682821 0.56 ENSG00000252725
 .
 2742
 0.34
chr15_31676742_31676893 0.55 KLF13
 Kruppel-like factor 13
 18460
 0.28
chr22_30175136_30175287 0.55 UQCR10
 ubiquinol-cytochrome c reductase, complex III subunit X
 11848
 0.12
chr10_80831884_80832062 0.55 ZMIZ1
 zinc finger, MIZ-type containing 1
 3181
 0.3
chr4_20268163_20268314 0.55 SLIT2
 slit homolog 2 (Drosophila)
 11695
 0.31
chr1_44249696_44249884 0.55 ST3GAL3
 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
 47856
 0.11
chr1_214741452_214741603 0.55 PTPN14
 protein tyrosine phosphatase, non-receptor type 14
 16961
 0.24
chr3_12960579_12960730 0.55 IQSEC1
 IQ motif and Sec7 domain 1
 48514
 0.12
chr8_62602534_62602708 0.55 ASPH
 aspartate beta-hydroxylase
 213
 0.95
chr20_34457569_34457720 0.55 ENSG00000199676
 .
 16358
 0.13
chr8_126496676_126496827 0.55 ENSG00000266452
 .
 39944
 0.18
chr14_56800333_56800607 0.55 TMEM260
 transmembrane protein 260
 154602
 0.04
chr5_54207045_54207196 0.54 RP11-45H22.3
 Uncharacterized protein
 46554
 0.13
chr6_5125637_5125928 0.54 ENSG00000265083
 .
 22774
 0.19
chr20_50248125_50248545 0.54 NFATC2
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
 68965
 0.12
chr5_148346010_148346161 0.54 RP11-44B19.1
3818
 0.26
chr2_74787629_74787875 0.54 LOXL3
 lysyl oxidase-like 3
 4935
 0.1
chr1_117690445_117690596 0.54 TRIM45
 tripartite motif containing 45
 25311
 0.15
chr9_97563146_97563297 0.54 C9orf3
 chromosome 9 open reading frame 3
 763
 0.65
chr19_2543854_2544412 0.54 ENSG00000252962
 .
 40994
 0.11
chr5_148515097_148515248 0.53 ABLIM3
 actin binding LIM protein family, member 3
 5874
 0.19
chr10_14519559_14519710 0.53 FRMD4A
 FERM domain containing 4A
 15493
 0.21
chr17_13447545_13447833 0.52 ENSG00000221698
 .
 726
 0.71
chr8_128403450_128403601 0.52 POU5F1B
 POU class 5 homeobox 1B
 23010
 0.23
chr17_62660365_62660516 0.52 SMURF2
 SMAD specific E3 ubiquitin protein ligase 2
 2254
 0.34
chr18_26734289_26734440 0.52 ENSG00000212085
 .
 42128
 0.18
chr22_36181419_36181847 0.52 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 7554
 0.27
chr20_33166516_33166667 0.51 MAP1LC3A
 microtubule-associated protein 1 light chain 3 alpha
 20069
 0.16
chr7_23470661_23470850 0.51 ENSG00000252590
 .
 19522
 0.16
chr20_33895079_33895258 0.51 FAM83C
 family with sequence similarity 83, member C
 14964
 0.1
chr22_44453249_44453400 0.51 PARVB
 parvin, beta
 11617
 0.25
chr5_67289012_67289163 0.51 ENSG00000223149
 .
 25814
 0.26
chr15_101717639_101717898 0.50 CHSY1
 chondroitin sulfate synthase 1
 74369
 0.09
chr1_222164593_222164744 0.50 ENSG00000212094
 .
 21764
 0.28
chr20_22775413_22775564 0.50 ENSG00000265151
 .
 61549
 0.14
chr16_67951318_67951477 0.50 CTRL
 chymotrypsin-like
 14368
 0.08
chr2_173290792_173290943 0.50 ITGA6
 integrin, alpha 6
 1215
 0.44
chr11_61463037_61463336 0.50 DAGLA
 diacylglycerol lipase, alpha
 15281
 0.16
chr3_69811903_69812159 0.50 MITF
 microphthalmia-associated transcription factor
 156
 0.97
chr8_117702787_117702938 0.50 EIF3H
 eukaryotic translation initiation factor 3, subunit H
 65161
 0.12
chr1_19271200_19271351 0.49 IFFO2
 intermediate filament family orphan 2
 10917
 0.19
chr8_124281675_124281846 0.49 ZHX1-C8ORF76
 ZHX1-C8ORF76 readthrough
 2133
 0.17
chr11_110668037_110668323 0.49 ARHGAP20
 Rho GTPase activating protein 20
 84268
 0.11
chr6_135174576_135174727 0.49 ALDH8A1
 aldehyde dehydrogenase 8 family, member A1
 75648
 0.11
chr15_49069969_49070120 0.48 RP11-485O10.2
5343
 0.21
chr1_192499348_192499877 0.48 RP5-1011O1.2
36735
 0.16
chr7_7593210_7593361 0.48 MIOS
 missing oocyte, meiosis regulator, homolog (Drosophila)
 13218
 0.22
chr8_127833738_127833889 0.48 ENSG00000212451
 .
 150046
 0.04
chr15_49073804_49073955 0.48 RP11-485O10.2
1508
 0.4
chr7_42717076_42717227 0.48 C7orf25
 chromosome 7 open reading frame 25
 234358
 0.02
chr1_115723224_115723375 0.47 TSPAN2
 tetraspanin 2
 91178
 0.08
chr19_43954759_43955038 0.47 LYPD3
 LY6/PLAUR domain containing 3
 14914
 0.13
chr4_148703798_148703949 0.47 ENSG00000264274
 .
 127
 0.96
chr1_21024911_21025062 0.47 KIF17
 kinesin family member 17
 18998
 0.13
chr20_11176893_11177136 0.47 C20orf187
 chromosome 20 open reading frame 187
 168203
 0.04
chr1_40423957_40424317 0.47 MFSD2A
 major facilitator superfamily domain containing 2A
 3315
 0.2
chr7_134604064_134604215 0.47 CALD1
 caldesmon 1
 1098
 0.63
chr7_29149222_29149373 0.47 CPVL
 carboxypeptidase, vitellogenic-like
 3240
 0.22
chr15_74373495_74373794 0.47 GOLGA6A
 golgin A6 family, member A
 1247
 0.38
chr20_23426178_23426329 0.47 CSTL1
 cystatin-like 1
 5368
 0.13
chr10_5594332_5594536 0.47 CALML3-AS1
 CALML3 antisense RNA 1
 26225
 0.13
chr19_612185_612336 0.46 AC005559.2
4899
 0.1
chr13_21607464_21607818 0.46 ENSG00000201821
 .
 5165
 0.17
chr12_54590925_54591203 0.46 SMUG1
 single-strand-selective monofunctional uracil-DNA glycosylase 1
 8286
 0.12
chr10_133110720_133110871 0.46 TCERG1L
 transcription elongation regulator 1-like
 811
 0.78
chr14_37466179_37466330 0.46 ENSG00000266327
 .
 44658
 0.17
chr1_152141043_152141216 0.46 FLG-AS1
 FLG antisense RNA 1
 528
 0.73
chr1_246020674_246020825 0.46 RP11-83A16.1
176104
 0.03
chr3_141866576_141866846 0.46 TFDP2
 transcription factor Dp-2 (E2F dimerization partner 2)
 1591
 0.36
chr6_82543726_82543877 0.46 ENSG00000206886
 .
 70060
 0.11
chr11_85453398_85453549 0.45 SYTL2
 synaptotagmin-like 2
 14402
 0.19
chr9_42854346_42854549 0.45 AC129778.2
1845
 0.47
chr14_68610729_68611179 0.45 ENSG00000244677
 .
 5671
 0.25
chr1_31575614_31575797 0.45 PUM1
 pumilio RNA-binding family member 1
 36867
 0.17
chr20_45947327_45947866 0.45 AL031666.2
 HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852
 350
 0.82
chr17_47527935_47528264 0.45 ENSG00000207127
 .
 33887
 0.1
chr2_47139549_47139700 0.45 MCFD2
 multiple coagulation factor deficiency 2
 1589
 0.3
chr4_114390008_114390159 0.45 CAMK2D
 calcium/calmodulin-dependent protein kinase II delta
 44915
 0.14
chr13_38069587_38069738 0.45 POSTN
 periostin, osteoblast specific factor
 103201
 0.08
chr8_95239241_95239392 0.45 CDH17
 cadherin 17, LI cadherin (liver-intestine)
 9785
 0.24
chr9_69654789_69655001 0.44 AL445665.1
 Protein LOC100996643
 4632
 0.3
chr19_41727336_41727487 0.44 CTD-2195B23.3
545
 0.64
chr10_61942717_61942868 0.44 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
 16138
 0.27
chr7_2146247_2146398 0.44 MAD1L1
 MAD1 mitotic arrest deficient-like 1 (yeast)
 1021
 0.66
chr9_67027339_67027528 0.44 ENSG00000265285
 .
 67500
 0.13

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0008215 spermine metabolic process(GO:0008215)
0.1 0.5 GO:0071731 response to nitric oxide(GO:0071731)
0.1 0.3 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.1 0.2 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1 0.1 GO:0002326 B cell lineage commitment(GO:0002326)
0.1 0.2 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.1 0.2 GO:0035583 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.5 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.1 0.2 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.2 GO:0021831 embryonic olfactory bulb interneuron precursor migration(GO:0021831)
0.1 0.2 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 0.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 0.2 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.1 0.6 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.2 GO:1903224 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.2 GO:0009169 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.2 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.2 GO:0002551 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.2 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.1 GO:0044557 relaxation of smooth muscle(GO:0044557) relaxation of vascular smooth muscle(GO:0060087)
0.0 0.2 GO:0030202 heparin metabolic process(GO:0030202)
0.0 0.1 GO:0097501 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.5 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0048840 otolith development(GO:0048840)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0051155 positive regulation of striated muscle cell differentiation(GO:0051155)
0.0 0.6 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.2 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.2 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.2 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.1 GO:0043276 anoikis(GO:0043276)
0.0 0.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.5 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.1 GO:0015820 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.1 GO:0001821 histamine secretion(GO:0001821)
0.0 0.1 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0 0.1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.3 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0 0.1 GO:0009120 deoxyribonucleoside metabolic process(GO:0009120)
0.0 0.0 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.0 GO:0032226 positive regulation of synaptic transmission, dopaminergic(GO:0032226)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.3 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 0.1 GO:0021570 rhombomere 4 development(GO:0021570)
0.0 0.1 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0 0.0 GO:0061043 vascular wound healing(GO:0061042) regulation of vascular wound healing(GO:0061043)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.0 GO:0031065 regulation of histone deacetylation(GO:0031063) positive regulation of histone deacetylation(GO:0031065)
0.0 0.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.1 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.1 GO:1904376 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.0 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.0 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.1 GO:0060055 angiogenesis involved in wound healing(GO:0060055)
0.0 0.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.0 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.1 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.0 GO:2000696 nephron tubule epithelial cell differentiation(GO:0072160) regulation of nephron tubule epithelial cell differentiation(GO:0072182) regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
0.0 0.1 GO:0009223 pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0 0.1 GO:0090224 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.0 0.0 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.0 0.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.1 GO:0051503 adenine nucleotide transport(GO:0051503)
0.0 0.0 GO:0048668 collateral sprouting(GO:0048668) regulation of collateral sprouting(GO:0048670)
0.0 0.1 GO:0000255 allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0 0.1 GO:0043097 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0 0.1 GO:0071636 positive regulation of transforming growth factor beta production(GO:0071636)
0.0 0.1 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367)
0.0 0.1 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.0 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.0 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.0 GO:1902305 regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.1 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.0 GO:0051712 positive regulation of killing of cells of other organism(GO:0051712)
0.0 0.0 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
0.0 0.1 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.1 GO:0090103 cochlea morphogenesis(GO:0090103)
0.0 0.2 GO:0035338 long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.1 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.3 GO:0051693 actin filament capping(GO:0051693)
0.0 0.0 GO:0045002 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.2 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:0034644 cellular response to UV(GO:0034644)
0.0 0.0 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.1 GO:0055064 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0 0.1 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.0 0.1 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.1 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0 0.0 GO:0046639 negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0 0.0 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.0 GO:0007412 axon target recognition(GO:0007412)
0.0 0.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0032431 activation of phospholipase A2 activity(GO:0032431)
0.0 0.1 GO:0090398 cellular senescence(GO:0090398)
0.0 0.0 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.0 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.0 GO:0034653 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.1 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.0 GO:0090047 obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0 0.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.1 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
0.0 0.1 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.2 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.0 GO:0034393 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.1 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.0 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.0 GO:0005997 xylulose metabolic process(GO:0005997)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.0 GO:0070254 mucus secretion(GO:0070254)
0.0 0.1 GO:0007435 salivary gland morphogenesis(GO:0007435)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.1 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.0 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.0 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.0 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.0 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.1 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.0 0.0 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.0 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.0 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.0 GO:0032060 bleb assembly(GO:0032060)
0.0 0.0 GO:0003148 outflow tract septum morphogenesis(GO:0003148)
0.0 0.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.0 GO:0050748 negative regulation of lipoprotein metabolic process(GO:0050748)
0.0 0.0 GO:0050955 thermoception(GO:0050955)
0.0 0.0 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.1 GO:0007494 midgut development(GO:0007494)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.1 GO:0001706 endoderm formation(GO:0001706)
0.0 0.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.1 GO:0046718 viral entry into host cell(GO:0046718)
0.0 0.0 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.0 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
0.0 0.0 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.0 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.0 GO:0021794 thalamus development(GO:0021794)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.0 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.1 GO:0031082 BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.1 GO:0043256 laminin complex(GO:0043256)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0030914 STAGA complex(GO:0030914)
0.0 0.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.0 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.2 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.0 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0 0.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.0 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.1 GO:0070822 Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 0.5 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 0.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 0.4 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.1 0.2 GO:0004948 calcitonin receptor activity(GO:0004948)
0.1 0.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.5 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.1 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.5 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0045118 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.2 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.2 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.1 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.1 GO:0070513 death domain binding(GO:0070513)
0.0 0.1 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.0 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.1 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.0 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.1 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.0 0.1 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.1 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.0 0.0 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.0 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.1 GO:0004645 phosphorylase activity(GO:0004645)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.1 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.3 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.0 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.0 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0 0.0 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)
0.0 0.0 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.0 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.0 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0042171 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.0 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.0 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.0 0.0 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.1 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.0 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.0 GO:0016531 metallochaperone activity(GO:0016530) copper chaperone activity(GO:0016531)
0.0 0.2 GO:0017147 Wnt-protein binding(GO:0017147)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.0 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.2 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.5 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 0.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.4 PID AURORA A PATHWAY Aurora A signaling
0.0 0.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.3 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.1 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.0 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.0 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.0 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.3 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES Genes involved in MAPK targets/ Nuclear events mediated by MAP kinases
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.1 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.7 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.1 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.2 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation