CREMA results: AR

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Transcription factors associated with AR_NR3C2

Gene Symbol	Gene ID	Gene Info
AR Ensembl NCBI GeneCards UniProt	ENSG00000169083.11	androgen receptor
NR3C2 Ensembl NCBI GeneCards UniProt	ENSG00000151623.10	nuclear receptor subfamily 3 group C member 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr4_149229242_149229393	NR3C2	128695	0.056491	-0.79	1.2e-02	Click!
chr4_149276556_149276707	NR3C2	81381	0.112390	-0.82	6.3e-03	Click!
chr4_149298361_149298512	NR3C2	59576	0.160340	-0.71	3.1e-02	Click!
chr4_149350438_149350589	NR3C2	7499	0.323590	-0.77	1.5e-02	Click!
chr4_149353611_149353762	NR3C2	4326	0.357265	-0.73	2.7e-02	Click!
chrX_66915365_66915591	AR	126747	0.062179	0.86	2.7e-03	Click!
chrX_66946272_66946453	AR	157631	0.042980	-0.75	2.1e-02	Click!
chrX_66955172_66955323	AR	166516	0.039019	-0.66	5.5e-02	Click!
chrX_67000391_67000546	AR	211737	0.025171	0.62	7.5e-02	Click!
chrX_67004998_67005149	AR	216342	0.024177	-0.65	5.6e-02	Click!

Showing 1 to 10 of 10 entries

Activity of the AR_NR3C2 motif across conditions

Conditions sorted by the z-value of the AR_NR3C2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_100004430_100004581	1.32	CCDC85C	coiled-coil domain containing 85C	2080	0.29
chr2_19848269_19848420	1.10	TTC32	tetratricopeptide repeat domain 32	253058	0.02
chr1_66932158_66932309	1.07	SGIP1	SH3-domain GRB2-like (endophilin) interacting protein 1	66833	0.12
chr18_34021656_34021807	1.06	FHOD3	formin homology 2 domain containing 3	102783	0.08
chr15_63045655_63045939	1.05	TLN2	talin 2	4992	0.22
chr2_3474011_3474213	1.00	TRAPPC12	trafficking protein particle complex 12	4668	0.18
chr6_141179242_141179445	0.99	ENSG00000264390	.	174392	0.04
chr12_27900681_27900869	0.99	ENSG00000252585	.	5032	0.13
chr10_30236708_30236859	0.96	KIAA1462	KIAA1462	111670	0.07
chr1_22196645_22196796	0.95	HSPG2	heparan sulfate proteoglycan 2	4479	0.22

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	GO:0007218	neuropeptide signaling pathway(GO:0007218)
0.2	0.6	GO:0008215	spermine metabolic process(GO:0008215)
0.1	0.6	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.6	GO:0045214	sarcomere organization(GO:0045214)
0.1	0.5	GO:0071731	response to nitric oxide(GO:0071731)
0.1	0.5	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.5	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.5	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.4	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	0.3	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)

Showing 1 to 10 of 168 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0001750	photoreceptor outer segment(GO:0001750)
0.1	0.3	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.2	GO:0071437	invadopodium(GO:0071437)
0.0	0.2	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.2	GO:0005915	zonula adherens(GO:0005915)
0.0	0.2	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.2	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.2	GO:0030914	STAGA complex(GO:0030914)
0.0	0.2	GO:0032039	integrator complex(GO:0032039)
0.0	0.2	GO:0016514	SWI/SNF complex(GO:0016514)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2	0.6	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1	0.5	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1	0.5	GO:0003840	gamma-glutamyltransferase activity(GO:0003840)
0.0	0.5	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.5	GO:0017137	Rab GTPase binding(GO:0017137)
0.1	0.4	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1	0.4	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.4	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.4	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)

Showing 1 to 10 of 119 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.1	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.5	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.4	PID AURORA A PATHWAY	Aurora A signaling
0.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.3	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway

Showing 1 to 10 of 25 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.7	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.0	0.6	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.6	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.0	0.5	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.4	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.4	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis

Showing 1 to 10 of 25 entries

Results for AR_NR3C2

Z-value: 1.48

Motif logo

Transcription factors associated with AR_NR3C2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the AR_NR3C2 motif across conditions

Conditions sorted by the z-value of the AR_NR3C2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: