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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ATF4

Z-value: 1.63

Motif logo

Transcription factors associated with ATF4

Gene Symbol	Gene ID	Gene Info
ATF4 Ensembl NCBI GeneCards UniProt	ENSG00000128272.10	ATF4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ATF4	chr22_39920267_39920552	3840	0.169811	-0.78	1.3e-02	Click!
ATF4	chr22_39914272_39914423	1353	0.346581	0.73	2.5e-02	Click!
ATF4	chr22_39918738_39919296	2448	0.215052	-0.70	3.5e-02	Click!
ATF4	chr22_39914606_39914905	945	0.478059	0.57	1.1e-01	Click!
ATF4	chr22_39918482_39918719	2031	0.246137	-0.57	1.1e-01	Click!

Activity of the ATF4 motif across conditions

Conditions sorted by the z-value of the ATF4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_30333675_30334003	1.37	ENSG00000199927	.	12188	0.3
chr2_119495850_119496001	1.20	EN1	engrailed homeobox 1	109329	0.07
chr9_124051991_124052278	1.12	GSN	gelsolin	3264	0.18
chr2_55327280_55327923	1.12	ENSG00000266376	.	8245	0.2
chr18_24326732_24327016	1.09	ENSG00000265369	.	57381	0.13
chr20_43124043_43124194	1.08	SERINC3	serine incorporator 3	9414	0.12
chr10_65462909_65463060	1.02	REEP3	receptor accessory protein 3	181861	0.03
chr4_86953260_86953440	1.01	RP13-514E23.1		18323	0.19
chr21_15734345_15734716	1.00	HSPA13	heat shock protein 70kDa family, member 13	20928	0.24
chr15_71119079_71119471	0.97	RP11-138H8.6		22834	0.14
chr10_99299975_99300262	0.97	ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)	32080	0.09
chr9_93102862_93103013	0.96	DIRAS2	DIRAS family, GTP-binding RAS-like 2	302449	0.01
chr4_26624592_26624880	0.91	ENSG00000265627	.	14376	0.23
chr16_72909394_72909957	0.90	ENSG00000251868	.	53784	0.12
chr15_36626292_36626443	0.87	C15orf41	chromosome 15 open reading frame 41	245445	0.02
chr1_8272197_8272744	0.87	ENSG00000200975	.	5813	0.24
chr3_105073937_105074088	0.86	ALCAM	activated leukocyte cell adhesion molecule	11741	0.33
chr4_39152584_39152984	0.84	RP11-360F5.1		24346	0.17
chr4_13920319_13920470	0.84	ENSG00000252092	.	260143	0.02
chr1_204381057_204381208	0.83	PPP1R15B	protein phosphatase 1, regulatory subunit 15B	213	0.94
chr20_23238843_23239098	0.81	NXT1	NTF2-like export factor 1	92403	0.05
chr12_52077625_52077776	0.81	SCN8A	sodium channel, voltage gated, type VIII, alpha subunit	2507	0.37
chr4_57887081_57887232	0.80	ENSG00000251703	.	18298	0.15
chr1_221490047_221490325	0.79	DUSP10	dual specificity phosphatase 10	420616	0.01
chr10_126734388_126734600	0.79	ENSG00000264572	.	13055	0.21
chr8_94910083_94910336	0.79	ENSG00000264448	.	18138	0.18
chr7_98000771_98000922	0.78	BAIAP2L1	BAI1-associated protein 2-like 1	29534	0.17
chr11_76288782_76288933	0.78	C11orf30	chromosome 11 open reading frame 30	31865	0.17
chr6_18216555_18216818	0.77	KDM1B	lysine (K)-specific demethylase 1B	30667	0.15
chr20_12997924_12998210	0.76	SPTLC3	serine palmitoyltransferase, long chain base subunit 3	8070	0.32
chr1_30995259_30995410	0.75	MATN1-AS1	MATN1 antisense RNA 1	196017	0.03
chr2_118881899_118882337	0.75	INSIG2	insulin induced gene 2	36068	0.19
chr7_111724278_111724664	0.75	DOCK4	dedicator of cytokinesis 4	80285	0.1
chr16_8623102_8623253	0.74	TMEM114	transmembrane protein 114	951	0.68
chr19_2524912_2525063	0.73	ENSG00000252962	.	21848	0.14
chr13_80350766_80350917	0.72	NDFIP2	Nedd4 family interacting protein 2	295253	0.01
chr9_84106067_84106472	0.72	TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	122168	0.06
chr16_9166899_9167138	0.72	C16orf72	chromosome 16 open reading frame 72	18487	0.16
chr15_60172096_60172247	0.72	FOXB1	forkhead box B1	124250	0.05
chr17_76325332_76325654	0.71	SOCS3	suppressor of cytokine signaling 3	30662	0.12
chr3_149812034_149812185	0.71	RP11-167H9.4		2121	0.33
chr3_141202423_141202574	0.71	RASA2	RAS p21 protein activator 2	3393	0.28
chr9_127154555_127154765	0.70	PSMB7	proteasome (prosome, macropain) subunit, beta type, 7	23058	0.17
chr6_146680396_146680547	0.70	ENSG00000222971	.	18915	0.29
chr8_8457538_8457689	0.68	ENSG00000263616	.	17448	0.22
chr10_74226369_74226629	0.68	RP11-167P22.3		35005	0.15
chr4_160195981_160196189	0.66	RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	7196	0.24
chr12_44241149_44241300	0.66	TMEM117	transmembrane protein 117	2557	0.34
chr3_9464516_9464980	0.65	ENSG00000266001	.	3286	0.2
chr6_36635004_36635155	0.64	ENSG00000251864	.	5536	0.15
chr4_170192796_170193656	0.64	SH3RF1	SH3 domain containing ring finger 1	970	0.68
chr10_79315415_79315652	0.64	ENSG00000199592	.	31274	0.22
chr2_9679702_9679882	0.64	ENSG00000238462	.	7318	0.17
chr10_59784388_59784539	0.64	ENSG00000238970	.	214058	0.02
chr5_73834033_73834384	0.62	HEXB	hexosaminidase B (beta polypeptide)	101640	0.07
chr11_63440539_63440690	0.62	ATL3	atlastin GTPase 3	1221	0.4
chr15_71118369_71118520	0.62	RP11-138H8.6		23665	0.14
chr2_29287035_29287186	0.62	C2orf71	chromosome 2 open reading frame 71	10017	0.14
chr1_207489899_207490187	0.62	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	4810	0.3
chr1_88319838_88319989	0.61	ENSG00000199318	.	400857	0.01
chr1_61629231_61629382	0.61	RP4-802A10.1		38901	0.19
chr6_130690312_130690483	0.61	TMEM200A	transmembrane protein 200A	3518	0.26
chr3_149812224_149812522	0.61	RP11-167H9.4		1857	0.36
chr11_33715982_33716133	0.61	RP4-541C22.5		2190	0.27
chr5_96190924_96191075	0.60	CTD-2260A17.2	Uncharacterized protein	18316	0.14
chr7_28102484_28102649	0.60	JAZF1	JAZF zinc finger 1	8737	0.26
chr2_179279617_179280113	0.60	AC009948.5		1115	0.47
chr21_34090483_34090634	0.59	SYNJ1	synaptojanin 1	8648	0.16
chr3_73815335_73815486	0.59	PDZRN3	PDZ domain containing ring finger 3	141319	0.05
chr2_64017553_64017895	0.58	UGP2	UDP-glucose pyrophosphorylase 2	50350	0.15
chr15_67799757_67800110	0.58	C15orf61	chromosome 15 open reading frame 61	13473	0.2
chr16_15698493_15698743	0.57	CTB-193M12.1		3713	0.19
chr10_65227481_65227632	0.57	JMJD1C	jumonji domain containing 1C	1834	0.34
chr6_56634837_56634988	0.57	DST	dystonin	15765	0.26
chr4_13921909_13922060	0.56	ENSG00000252092	.	261733	0.02
chr22_41776460_41776636	0.56	TEF	thyrotrophic embryonic factor	1385	0.34
chr3_71582773_71583007	0.56	ENSG00000221264	.	8350	0.21
chr17_70808576_70808727	0.56	ENSG00000252274	.	6460	0.22
chr1_234639139_234639392	0.56	TARBP1	TAR (HIV-1) RNA binding protein 1	24416	0.19
chr10_44338826_44338977	0.56	ENSG00000238957	.	191087	0.03
chr12_89728661_89728921	0.56	DUSP6	dual specificity phosphatase 6	16157	0.24
chr7_101498442_101498914	0.56	CTA-339C12.1		30669	0.18
chr2_174016909_174017060	0.55	MLK7-AS1	MLK7 antisense RNA 1	55356	0.13
chr5_73092459_73092753	0.55	CTC-575I10.1		10290	0.2
chr5_81644909_81645060	0.55	ATP6AP1L	ATPase, H+ transporting, lysosomal accessory protein 1-like	43818	0.19
chr10_22284671_22284822	0.55	DNAJC1	DnaJ (Hsp40) homolog, subfamily C, member 1	7582	0.28
chr2_47140554_47140705	0.55	MCFD2	multiple coagulation factor deficiency 2	584	0.67
chr10_91106448_91106732	0.55	LIPA	lipase A, lysosomal acid, cholesterol esterase	4129	0.16
chr2_228681785_228681989	0.55	CCL20	chemokine (C-C motif) ligand 20	3317	0.27
chr6_5206187_5206422	0.55	ENSG00000264541	.	18726	0.19
chr6_13762651_13763628	0.54	MCUR1	mitochondrial calcium uniporter regulator 1	38438	0.15
chr1_152001823_152002025	0.54	S100A11	S100 calcium binding protein A11	7587	0.15
chr1_180092706_180092857	0.54	CEP350	centrosomal protein 350kDa	29932	0.18
chr13_43407082_43407233	0.54	FAM216B	family with sequence similarity 216, member B	51406	0.18
chr2_13058685_13058836	0.53	ENSG00000264370	.	181267	0.03
chr20_61303299_61303450	0.53	SLCO4A1	solute carrier organic anion transporter family, member 4A1	4209	0.14
chr13_96408525_96408676	0.52	ENSG00000251901	.	41568	0.18
chr3_138582119_138582540	0.51	PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	28549	0.2
chr10_75652450_75652601	0.51	PLAU	plasminogen activator, urokinase	16410	0.11
chr13_110033704_110033855	0.51	MYO16-AS1	MYO16 antisense RNA 1	179948	0.03
chr6_23175706_23175857	0.50	ENSG00000207394	.	50466	0.2
chr7_129338898_129339049	0.50	NRF1	nuclear respiratory factor 1	41782	0.13
chr21_36168084_36168235	0.50	AP000330.8		50025	0.16
chr3_172345080_172345231	0.50	AC007919.2	HCG1787166; PRO1163; Uncharacterized protein	16328	0.19
chr5_16736411_16736625	0.50	MYO10	myosin X	1978	0.43
chr4_54373291_54373442	0.49	LNX1-AS1	LNX1 antisense RNA 1	5308	0.25
chr6_149333665_149333816	0.49	RP11-162J8.3		19969	0.23
chr1_33453155_33453306	0.49	RP1-117O3.2		554	0.7
chr2_121507260_121507411	0.49	GLI2	GLI family zinc finger 2	13512	0.29
chr17_36571605_36571871	0.49	ENSG00000266103	.	5696	0.17
chr10_33604953_33605104	0.49	NRP1	neuropilin 1	18282	0.22
chr11_58394708_58394859	0.49	CNTF	ciliary neurotrophic factor	4637	0.18
chr2_205441256_205441407	0.48	PARD3B	par-3 family cell polarity regulator beta	30608	0.27
chr5_138517708_138518085	0.48	SIL1	SIL1 nucleotide exchange factor	14314	0.18
chr7_44298814_44299210	0.48	CAMK2B	calcium/calmodulin-dependent protein kinase II beta	17107	0.18
chr11_102097026_102097177	0.48	RP11-864G5.3		4552	0.23
chr12_19395564_19395847	0.48	PLEKHA5	pleckstrin homology domain containing, family A member 5	5847	0.26
chr4_102023208_102023359	0.48	ENSG00000221265	.	228288	0.02
chr8_123651385_123651590	0.47	ENSG00000238901	.	32043	0.23
chr8_38483788_38483951	0.47	C8orf86	chromosome 8 open reading frame 86	97689	0.06
chr1_64211693_64212078	0.47	ROR1	receptor tyrosine kinase-like orphan receptor 1	27808	0.21
chr11_20473321_20473556	0.47	PRMT3	protein arginine methyltransferase 3	64176	0.13
chr5_136899404_136899555	0.47	ENSG00000221612	.	30336	0.19
chr18_434239_434644	0.47	RP11-720L2.2		10025	0.23
chr5_118733387_118734036	0.47	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	41981	0.13
chr6_14728915_14729066	0.46	ENSG00000206960	.	82224	0.11
chr1_222628880_222629091	0.46	ENSG00000222399	.	48092	0.16
chr4_146764367_146764859	0.46	RP11-181K12.2		10343	0.26
chr11_46016222_46016373	0.46	PHF21A	PHD finger protein 21A	48877	0.11
chr3_171685115_171685266	0.45	FNDC3B	fibronectin type III domain containing 3B	72228	0.1
chr1_184758212_184758610	0.45	FAM129A	family with sequence similarity 129, member A	16708	0.19
chr9_37995152_37995751	0.45	ENSG00000251745	.	58686	0.12
chr5_137854815_137854966	0.45	ETF1	eukaryotic translation termination factor 1	22510	0.13
chr3_58045428_58045645	0.45	FLNB	filamin B, beta	18520	0.24
chr12_28692903_28693202	0.44	CCDC91	coiled-coil domain containing 91	8944	0.27
chr14_53320261_53320477	0.44	FERMT2	fermitin family member 2	10870	0.21
chr22_38568821_38569004	0.43	PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)	7499	0.14
chr19_31807413_31807564	0.43	AC007796.1		32299	0.2
chr6_138225502_138226170	0.43	RP11-356I2.4		36466	0.18
chr18_42900853_42901004	0.43	SLC14A2	solute carrier family 14 (urea transporter), member 2	107968	0.06
chr13_110572258_110572409	0.43	ENSG00000201161	.	4890	0.33
chr7_81589929_81590080	0.43	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	10401	0.24
chr18_46074818_46074969	0.43	CTIF	CBP80/20-dependent translation initiation factor	8427	0.26
chr2_208176087_208176546	0.43	ENSG00000221628	.	42168	0.17
chr14_51471507_51471658	0.42	PYGL	phosphorylase, glycogen, liver	60128	0.1
chr10_79021361_79021706	0.42	RP11-328K22.1		52166	0.15
chr20_19051967_19052205	0.42	ENSG00000264669	.	54343	0.15
chr11_9818939_9819090	0.42	SBF2	SET binding factor 2	8263	0.17
chr14_85983583_85983734	0.41	RP11-497E19.2	Uncharacterized protein	11285	0.25
chr1_66277924_66278361	0.41	PDE4B	phosphodiesterase 4B, cAMP-specific	19278	0.24
chr2_162969937_162970139	0.40	GCG	glucagon	38875	0.13
chr11_9236582_9237086	0.40	RP11-5L12.1		30222	0.16
chr6_41065364_41065515	0.40	OARD1	O-acyl-ADP-ribose deacylase 1	58	0.96
chr3_99721724_99721891	0.40	ENSG00000264897	.	38565	0.19
chr2_145203456_145203749	0.40	ZEB2	zinc finger E-box binding homeobox 2	15465	0.27
chr1_63142438_63142826	0.40	DOCK7	dedicator of cytokinesis 7	11321	0.2
chr12_67927970_67928121	0.39	DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	114073	0.07
chr6_7058768_7059017	0.39	ENSG00000251762	.	18113	0.22
chr4_151070613_151070764	0.39	ENSG00000238721	.	60170	0.14
chr11_32421982_32422133	0.39	WT1	Wilms tumor 1	104	0.98
chr8_28565507_28565705	0.39	EXTL3	exostosin-like glycosyltransferase 3	2269	0.3
chr4_48915724_48915875	0.39	OCIAD2	OCIA domain containing 2	6954	0.2
chr11_57045647_57045894	0.39	APLNR	apelin receptor	41095	0.09
chr8_124179944_124180219	0.38	FAM83A	family with sequence similarity 83, member A	11206	0.12
chr3_50704589_50704740	0.38	ENSG00000272543	.	7847	0.16
chr5_14305370_14305521	0.38	TRIO	trio Rho guanine nucleotide exchange factor	14359	0.31
chr2_190118686_190118837	0.38	ENSG00000266817	.	57726	0.13
chr8_116461452_116461961	0.38	TRPS1	trichorhinophalangeal syndrome I	42742	0.19
chr18_53400073_53400224	0.38	TCF4	transcription factor 4	68130	0.14
chr4_8527517_8527668	0.37	GPR78	G protein-coupled receptor 78	54701	0.11
chr11_74031798_74031949	0.37	P4HA3	prolyl 4-hydroxylase, alpha polypeptide III	9171	0.18
chr8_26469143_26469294	0.37	DPYSL2	dihydropyrimidinase-like 2	33297	0.21
chr1_198227986_198228137	0.37	NEK7	NIMA-related kinase 7	38132	0.23
chr1_6230966_6231267	0.37	CHD5	chromodomain helicase DNA binding protein 5	9067	0.14
chr22_43263821_43263972	0.37	ARFGAP3	ADP-ribosylation factor GTPase activating protein 3	9784	0.23
chr15_42578664_42578815	0.36	GANC	glucosidase, alpha; neutral C	12299	0.16
chr11_129093775_129094069	0.36	ENSG00000199260	.	21061	0.22
chr9_128223375_128223526	0.36	MAPKAP1	mitogen-activated protein kinase associated protein 1	23330	0.21
chr2_46066755_46066906	0.36	PRKCE	protein kinase C, epsilon	161211	0.04
chr9_128005655_128005806	0.36	RP11-65N13.8		1788	0.26
chr1_186782472_186782623	0.36	PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)	15538	0.29
chr2_109565955_109566106	0.36	EDAR	ectodysplasin A receptor	39695	0.19
chr3_42068290_42068573	0.35	TRAK1	trafficking protein, kinesin binding 1	64131	0.11
chr11_72680748_72681422	0.35	FCHSD2	FCH and double SH3 domains 2	18972	0.22
chr1_61586786_61586937	0.35	RP4-802A10.1		3544	0.28
chr16_48400227_48400867	0.35	SIAH1	siah E3 ubiquitin protein ligase 1	735	0.66
chr4_108921158_108921309	0.35	HADH	hydroxyacyl-CoA dehydrogenase	4558	0.22
chr11_34393224_34393428	0.35	ABTB2	ankyrin repeat and BTB (POZ) domain containing 2	13771	0.25
chr8_129189248_129189490	0.35	ENSG00000221261	.	27007	0.21
chr8_93552671_93552822	0.35	ENSG00000221172	.	94817	0.09
chr15_40200299_40200575	0.35	GPR176	G protein-coupled receptor 176	11989	0.15
chr6_89744532_89744683	0.34	ENSG00000223001	.	28802	0.13
chr3_131448487_131448638	0.34	CPNE4	copine IV	195863	0.03
chr10_75346559_75346987	0.34	USP54	ubiquitin specific peptidase 54	4323	0.16
chr14_63940302_63940453	0.34	ENSG00000252463	.	4115	0.18
chr4_178362396_178362599	0.34	AGA	aspartylglucosaminidase	1160	0.46
chr9_123495391_123495542	0.34	MEGF9	multiple EGF-like-domains 9	18718	0.21
chr14_50469321_50469915	0.34	C14orf182	chromosome 14 open reading frame 182	4620	0.21
chr8_37639065_37639216	0.34	GPR124	G protein-coupled receptor 124	2569	0.21
chr8_141607678_141608368	0.34	AGO2	argonaute RISC catalytic component 2	7964	0.25

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1	0.8	GO:0006983	ER overload response(GO:0006983)
0.1	0.2	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.1	0.2	GO:0021508	floor plate formation(GO:0021508)
0.1	0.2	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.2	GO:0033345	asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.2	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.2	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.0	0.2	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.2	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0046532	regulation of photoreceptor cell differentiation(GO:0046532)
0.0	0.2	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0072191	ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0	0.1	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.1	GO:0060068	vagina development(GO:0060068)
0.0	0.1	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.2	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0032347	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0033023	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.1	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.4	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.2	GO:0071501	SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0001865	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.2	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.1	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.1	GO:0048343	paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.3	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.0	0.1	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.1	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.0	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.0	GO:0014848	urinary tract smooth muscle contraction(GO:0014848)
0.0	0.0	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.4	GO:0090659	adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.0	0.1	GO:0048488	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.3	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.2	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.2	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.0	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0046471	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0055057	neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.0	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.1	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.1	GO:0060039	pericardium development(GO:0060039)
0.0	0.1	GO:0051957	positive regulation of glutamate secretion(GO:0014049) positive regulation of amino acid transport(GO:0051957)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.0	GO:0009730	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.0	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.0	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.0	GO:0043558	regulation of translational initiation in response to stress(GO:0043558)
0.0	0.0	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.0	0.0	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.2	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.0	0.0	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.2	GO:0050812	acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.0	GO:0031394	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.0	GO:0006085	acetyl-CoA biosynthetic process(GO:0006085)
0.0	0.0	GO:0032097	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.2	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.0	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.2	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.1	GO:0046498	S-adenosylhomocysteine metabolic process(GO:0046498)
0.0	0.0	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.0	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:0030878	thyroid gland development(GO:0030878)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.0	GO:0051097	negative regulation of helicase activity(GO:0051097)
0.0	0.1	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	0.0	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.0	GO:0034204	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.0	GO:0009648	photoperiodism(GO:0009648)
0.0	0.0	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0001696	gastric acid secretion(GO:0001696)
0.0	0.1	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.0	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.0	0.1	GO:0034695	response to prostaglandin E(GO:0034695)
0.0	0.1	GO:0030917	midbrain-hindbrain boundary development(GO:0030917)
0.0	0.0	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0032781	positive regulation of ATPase activity(GO:0032781)
0.0	0.1	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.0	0.0	GO:0032692	negative regulation of interleukin-1 production(GO:0032692)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.8	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.1	0.3	GO:0033268	node of Ranvier(GO:0033268)
0.1	0.3	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.2	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.2	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.2	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.2	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.4	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	0.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.0	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.1	GO:0071817	MMXD complex(GO:0071817)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.1	GO:0032838	cell projection cytoplasm(GO:0032838)
0.0	0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.0	GO:0031933	telomeric heterochromatin(GO:0031933)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.1	0.2	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1	0.1	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.1	0.2	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1	0.2	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.2	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.2	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.4	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.3	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	1.1	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.3	GO:1905030	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.2	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.2	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0043295	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.1	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696) BMP receptor binding(GO:0070700)
0.0	0.0	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.0	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.0	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.0	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.0	GO:0002060	nucleobase binding(GO:0002054) purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.0	GO:0070643	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0048038	quinone binding(GO:0048038)
0.0	0.0	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.1	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0019841	retinol binding(GO:0019841)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.1	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.0	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.5	PID RAS PATHWAY	Regulation of Ras family activation
0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	PID AVB3 OPN PATHWAY	Osteopontin-mediated events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	REACTOME SIGNALING BY FGFR1 MUTANTS	Genes involved in Signaling by FGFR1 mutants
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.2	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors