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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for ATF4

Z-value: 1.63

Motif logo

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.10 activating transcription factor 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr22_39920267_39920552ATF438400.169811-0.781.3e-02Click!
chr22_39914272_39914423ATF413530.3465810.732.5e-02Click!
chr22_39918738_39919296ATF424480.215052-0.703.5e-02Click!
chr22_39914606_39914905ATF49450.4780590.571.1e-01Click!
chr22_39918482_39918719ATF420310.246137-0.571.1e-01Click!

Activity of the ATF4 motif across conditions

Conditions sorted by the z-value of the ATF4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr3_30333675_30334003 1.37 ENSG00000199927
 .
 12188
 0.3
chr2_119495850_119496001 1.20 EN1
 engrailed homeobox 1
 109329
 0.07
chr9_124051991_124052278 1.12 GSN
 gelsolin
 3264
 0.18
chr2_55327280_55327923 1.12 ENSG00000266376
 .
 8245
 0.2
chr18_24326732_24327016 1.09 ENSG00000265369
 .
 57381
 0.13
chr20_43124043_43124194 1.08 SERINC3
 serine incorporator 3
 9414
 0.12
chr10_65462909_65463060 1.02 REEP3
 receptor accessory protein 3
 181861
 0.03
chr4_86953260_86953440 1.01 RP13-514E23.1
18323
 0.19
chr21_15734345_15734716 1.00 HSPA13
 heat shock protein 70kDa family, member 13
 20928
 0.24
chr15_71119079_71119471 0.97 RP11-138H8.6
22834
 0.14
chr10_99299975_99300262 0.97 ANKRD2
 ankyrin repeat domain 2 (stretch responsive muscle)
 32080
 0.09
chr9_93102862_93103013 0.96 DIRAS2
 DIRAS family, GTP-binding RAS-like 2
 302449
 0.01
chr4_26624592_26624880 0.91 ENSG00000265627
 .
 14376
 0.23
chr16_72909394_72909957 0.90 ENSG00000251868
 .
 53784
 0.12
chr15_36626292_36626443 0.87 C15orf41
 chromosome 15 open reading frame 41
 245445
 0.02
chr1_8272197_8272744 0.87 ENSG00000200975
 .
 5813
 0.24
chr3_105073937_105074088 0.86 ALCAM
 activated leukocyte cell adhesion molecule
 11741
 0.33
chr4_39152584_39152984 0.84 RP11-360F5.1
24346
 0.17
chr4_13920319_13920470 0.84 ENSG00000252092
 .
 260143
 0.02
chr1_204381057_204381208 0.83 PPP1R15B
 protein phosphatase 1, regulatory subunit 15B
 213
 0.94
chr20_23238843_23239098 0.81 NXT1
 NTF2-like export factor 1
 92403
 0.05
chr12_52077625_52077776 0.81 SCN8A
 sodium channel, voltage gated, type VIII, alpha subunit
 2507
 0.37
chr4_57887081_57887232 0.80 ENSG00000251703
 .
 18298
 0.15
chr1_221490047_221490325 0.79 DUSP10
 dual specificity phosphatase 10
 420616
 0.01
chr10_126734388_126734600 0.79 ENSG00000264572
 .
 13055
 0.21
chr8_94910083_94910336 0.79 ENSG00000264448
 .
 18138
 0.18
chr7_98000771_98000922 0.78 BAIAP2L1
 BAI1-associated protein 2-like 1
 29534
 0.17
chr11_76288782_76288933 0.78 C11orf30
 chromosome 11 open reading frame 30
 31865
 0.17
chr6_18216555_18216818 0.77 KDM1B
 lysine (K)-specific demethylase 1B
 30667
 0.15
chr20_12997924_12998210 0.76 SPTLC3
 serine palmitoyltransferase, long chain base subunit 3
 8070
 0.32
chr1_30995259_30995410 0.75 MATN1-AS1
 MATN1 antisense RNA 1
 196017
 0.03
chr2_118881899_118882337 0.75 INSIG2
 insulin induced gene 2
 36068
 0.19
chr7_111724278_111724664 0.75 DOCK4
 dedicator of cytokinesis 4
 80285
 0.1
chr16_8623102_8623253 0.74 TMEM114
 transmembrane protein 114
 951
 0.68
chr19_2524912_2525063 0.73 ENSG00000252962
 .
 21848
 0.14
chr13_80350766_80350917 0.72 NDFIP2
 Nedd4 family interacting protein 2
 295253
 0.01
chr9_84106067_84106472 0.72 TLE1
 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
 122168
 0.06
chr16_9166899_9167138 0.72 C16orf72
 chromosome 16 open reading frame 72
 18487
 0.16
chr15_60172096_60172247 0.72 FOXB1
 forkhead box B1
 124250
 0.05
chr17_76325332_76325654 0.71 SOCS3
 suppressor of cytokine signaling 3
 30662
 0.12
chr3_149812034_149812185 0.71 RP11-167H9.4
2121
 0.33
chr3_141202423_141202574 0.71 RASA2
 RAS p21 protein activator 2
 3393
 0.28
chr9_127154555_127154765 0.70 PSMB7
 proteasome (prosome, macropain) subunit, beta type, 7
 23058
 0.17
chr6_146680396_146680547 0.70 ENSG00000222971
 .
 18915
 0.29
chr8_8457538_8457689 0.68 ENSG00000263616
 .
 17448
 0.22
chr10_74226369_74226629 0.68 RP11-167P22.3
35005
 0.15
chr4_160195981_160196189 0.66 RAPGEF2
 Rap guanine nucleotide exchange factor (GEF) 2
 7196
 0.24
chr12_44241149_44241300 0.66 TMEM117
 transmembrane protein 117
 2557
 0.34
chr3_9464516_9464980 0.65 ENSG00000266001
 .
 3286
 0.2
chr6_36635004_36635155 0.64 ENSG00000251864
 .
 5536
 0.15
chr4_170192796_170193656 0.64 SH3RF1
 SH3 domain containing ring finger 1
 970
 0.68
chr10_79315415_79315652 0.64 ENSG00000199592
 .
 31274
 0.22
chr2_9679702_9679882 0.64 ENSG00000238462
 .
 7318
 0.17
chr10_59784388_59784539 0.64 ENSG00000238970
 .
 214058
 0.02
chr5_73834033_73834384 0.62 HEXB
 hexosaminidase B (beta polypeptide)
 101640
 0.07
chr11_63440539_63440690 0.62 ATL3
 atlastin GTPase 3
 1221
 0.4
chr15_71118369_71118520 0.62 RP11-138H8.6
23665
 0.14
chr2_29287035_29287186 0.62 C2orf71
 chromosome 2 open reading frame 71
 10017
 0.14
chr1_207489899_207490187 0.62 CD55
 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
 4810
 0.3
chr1_88319838_88319989 0.61 ENSG00000199318
 .
 400857
 0.01
chr1_61629231_61629382 0.61 RP4-802A10.1
38901
 0.19
chr6_130690312_130690483 0.61 TMEM200A
 transmembrane protein 200A
 3518
 0.26
chr3_149812224_149812522 0.61 RP11-167H9.4
1857
 0.36
chr11_33715982_33716133 0.61 RP4-541C22.5
2190
 0.27
chr5_96190924_96191075 0.60 CTD-2260A17.2
 Uncharacterized protein
 18316
 0.14
chr7_28102484_28102649 0.60 JAZF1
 JAZF zinc finger 1
 8737
 0.26
chr2_179279617_179280113 0.60 AC009948.5
1115
 0.47
chr21_34090483_34090634 0.59 SYNJ1
 synaptojanin 1
 8648
 0.16
chr3_73815335_73815486 0.59 PDZRN3
 PDZ domain containing ring finger 3
 141319
 0.05
chr2_64017553_64017895 0.58 UGP2
 UDP-glucose pyrophosphorylase 2
 50350
 0.15
chr15_67799757_67800110 0.58 C15orf61
 chromosome 15 open reading frame 61
 13473
 0.2
chr16_15698493_15698743 0.57 CTB-193M12.1
3713
 0.19
chr10_65227481_65227632 0.57 JMJD1C
 jumonji domain containing 1C
 1834
 0.34
chr6_56634837_56634988 0.57 DST
 dystonin
 15765
 0.26
chr4_13921909_13922060 0.56 ENSG00000252092
 .
 261733
 0.02
chr22_41776460_41776636 0.56 TEF
 thyrotrophic embryonic factor
 1385
 0.34
chr3_71582773_71583007 0.56 ENSG00000221264
 .
 8350
 0.21
chr17_70808576_70808727 0.56 ENSG00000252274
 .
 6460
 0.22
chr1_234639139_234639392 0.56 TARBP1
 TAR (HIV-1) RNA binding protein 1
 24416
 0.19
chr10_44338826_44338977 0.56 ENSG00000238957
 .
 191087
 0.03
chr12_89728661_89728921 0.56 DUSP6
 dual specificity phosphatase 6
 16157
 0.24
chr7_101498442_101498914 0.56 CTA-339C12.1
30669
 0.18
chr2_174016909_174017060 0.55 MLK7-AS1
 MLK7 antisense RNA 1
 55356
 0.13
chr5_73092459_73092753 0.55 CTC-575I10.1
10290
 0.2
chr5_81644909_81645060 0.55 ATP6AP1L
 ATPase, H+ transporting, lysosomal accessory protein 1-like
 43818
 0.19
chr10_22284671_22284822 0.55 DNAJC1
 DnaJ (Hsp40) homolog, subfamily C, member 1
 7582
 0.28
chr2_47140554_47140705 0.55 MCFD2
 multiple coagulation factor deficiency 2
 584
 0.67
chr10_91106448_91106732 0.55 LIPA
 lipase A, lysosomal acid, cholesterol esterase
 4129
 0.16
chr2_228681785_228681989 0.55 CCL20
 chemokine (C-C motif) ligand 20
 3317
 0.27
chr6_5206187_5206422 0.55 ENSG00000264541
 .
 18726
 0.19
chr6_13762651_13763628 0.54 MCUR1
 mitochondrial calcium uniporter regulator 1
 38438
 0.15
chr1_152001823_152002025 0.54 S100A11
 S100 calcium binding protein A11
 7587
 0.15
chr1_180092706_180092857 0.54 CEP350
 centrosomal protein 350kDa
 29932
 0.18
chr13_43407082_43407233 0.54 FAM216B
 family with sequence similarity 216, member B
 51406
 0.18
chr2_13058685_13058836 0.53 ENSG00000264370
 .
 181267
 0.03
chr20_61303299_61303450 0.53 SLCO4A1
 solute carrier organic anion transporter family, member 4A1
 4209
 0.14
chr13_96408525_96408676 0.52 ENSG00000251901
 .
 41568
 0.18
chr3_138582119_138582540 0.51 PIK3CB
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
 28549
 0.2
chr10_75652450_75652601 0.51 PLAU
 plasminogen activator, urokinase
 16410
 0.11
chr13_110033704_110033855 0.51 MYO16-AS1
 MYO16 antisense RNA 1
 179948
 0.03
chr6_23175706_23175857 0.50 ENSG00000207394
 .
 50466
 0.2
chr7_129338898_129339049 0.50 NRF1
 nuclear respiratory factor 1
 41782
 0.13
chr21_36168084_36168235 0.50 AP000330.8
50025
 0.16
chr3_172345080_172345231 0.50 AC007919.2
 HCG1787166; PRO1163; Uncharacterized protein
 16328
 0.19
chr5_16736411_16736625 0.50 MYO10
 myosin X
 1978
 0.43
chr4_54373291_54373442 0.49 LNX1-AS1
 LNX1 antisense RNA 1
 5308
 0.25
chr6_149333665_149333816 0.49 RP11-162J8.3
19969
 0.23
chr1_33453155_33453306 0.49 RP1-117O3.2
554
 0.7
chr2_121507260_121507411 0.49 GLI2
 GLI family zinc finger 2
 13512
 0.29
chr17_36571605_36571871 0.49 ENSG00000266103
 .
 5696
 0.17
chr10_33604953_33605104 0.49 NRP1
 neuropilin 1
 18282
 0.22
chr11_58394708_58394859 0.49 CNTF
 ciliary neurotrophic factor
 4637
 0.18
chr2_205441256_205441407 0.48 PARD3B
 par-3 family cell polarity regulator beta
 30608
 0.27
chr5_138517708_138518085 0.48 SIL1
 SIL1 nucleotide exchange factor
 14314
 0.18
chr7_44298814_44299210 0.48 CAMK2B
 calcium/calmodulin-dependent protein kinase II beta
 17107
 0.18
chr11_102097026_102097177 0.48 RP11-864G5.3
4552
 0.23
chr12_19395564_19395847 0.48 PLEKHA5
 pleckstrin homology domain containing, family A member 5
 5847
 0.26
chr4_102023208_102023359 0.48 ENSG00000221265
 .
 228288
 0.02
chr8_123651385_123651590 0.47 ENSG00000238901
 .
 32043
 0.23
chr8_38483788_38483951 0.47 C8orf86
 chromosome 8 open reading frame 86
 97689
 0.06
chr1_64211693_64212078 0.47 ROR1
 receptor tyrosine kinase-like orphan receptor 1
 27808
 0.21
chr11_20473321_20473556 0.47 PRMT3
 protein arginine methyltransferase 3
 64176
 0.13
chr5_136899404_136899555 0.47 ENSG00000221612
 .
 30336
 0.19
chr18_434239_434644 0.47 RP11-720L2.2
10025
 0.23
chr5_118733387_118734036 0.47 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 41981
 0.13
chr6_14728915_14729066 0.46 ENSG00000206960
 .
 82224
 0.11
chr1_222628880_222629091 0.46 ENSG00000222399
 .
 48092
 0.16
chr4_146764367_146764859 0.46 RP11-181K12.2
10343
 0.26
chr11_46016222_46016373 0.46 PHF21A
 PHD finger protein 21A
 48877
 0.11
chr3_171685115_171685266 0.45 FNDC3B
 fibronectin type III domain containing 3B
 72228
 0.1
chr1_184758212_184758610 0.45 FAM129A
 family with sequence similarity 129, member A
 16708
 0.19
chr9_37995152_37995751 0.45 ENSG00000251745
 .
 58686
 0.12
chr5_137854815_137854966 0.45 ETF1
 eukaryotic translation termination factor 1
 22510
 0.13
chr3_58045428_58045645 0.45 FLNB
 filamin B, beta
 18520
 0.24
chr12_28692903_28693202 0.44 CCDC91
 coiled-coil domain containing 91
 8944
 0.27
chr14_53320261_53320477 0.44 FERMT2
 fermitin family member 2
 10870
 0.21
chr22_38568821_38569004 0.43 PLA2G6
 phospholipase A2, group VI (cytosolic, calcium-independent)
 7499
 0.14
chr19_31807413_31807564 0.43 AC007796.1
32299
 0.2
chr6_138225502_138226170 0.43 RP11-356I2.4
36466
 0.18
chr18_42900853_42901004 0.43 SLC14A2
 solute carrier family 14 (urea transporter), member 2
 107968
 0.06
chr13_110572258_110572409 0.43 ENSG00000201161
 .
 4890
 0.33
chr7_81589929_81590080 0.43 CACNA2D1
 calcium channel, voltage-dependent, alpha 2/delta subunit 1
 10401
 0.24
chr18_46074818_46074969 0.43 CTIF
 CBP80/20-dependent translation initiation factor
 8427
 0.26
chr2_208176087_208176546 0.43 ENSG00000221628
 .
 42168
 0.17
chr14_51471507_51471658 0.42 PYGL
 phosphorylase, glycogen, liver
 60128
 0.1
chr10_79021361_79021706 0.42 RP11-328K22.1
52166
 0.15
chr20_19051967_19052205 0.42 ENSG00000264669
 .
 54343
 0.15
chr11_9818939_9819090 0.42 SBF2
 SET binding factor 2
 8263
 0.17
chr14_85983583_85983734 0.41 RP11-497E19.2
 Uncharacterized protein
 11285
 0.25
chr1_66277924_66278361 0.41 PDE4B
 phosphodiesterase 4B, cAMP-specific
 19278
 0.24
chr2_162969937_162970139 0.40 GCG
 glucagon
 38875
 0.13
chr11_9236582_9237086 0.40 RP11-5L12.1
30222
 0.16
chr6_41065364_41065515 0.40 OARD1
 O-acyl-ADP-ribose deacylase 1
 58
 0.96
chr3_99721724_99721891 0.40 ENSG00000264897
 .
 38565
 0.19
chr2_145203456_145203749 0.40 ZEB2
 zinc finger E-box binding homeobox 2
 15465
 0.27
chr1_63142438_63142826 0.40 DOCK7
 dedicator of cytokinesis 7
 11321
 0.2
chr12_67927970_67928121 0.39 DYRK2
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
 114073
 0.07
chr6_7058768_7059017 0.39 ENSG00000251762
 .
 18113
 0.22
chr4_151070613_151070764 0.39 ENSG00000238721
 .
 60170
 0.14
chr11_32421982_32422133 0.39 WT1
 Wilms tumor 1
 104
 0.98
chr8_28565507_28565705 0.39 EXTL3
 exostosin-like glycosyltransferase 3
 2269
 0.3
chr4_48915724_48915875 0.39 OCIAD2
 OCIA domain containing 2
 6954
 0.2
chr11_57045647_57045894 0.39 APLNR
 apelin receptor
 41095
 0.09
chr8_124179944_124180219 0.38 FAM83A
 family with sequence similarity 83, member A
 11206
 0.12
chr3_50704589_50704740 0.38 ENSG00000272543
 .
 7847
 0.16
chr5_14305370_14305521 0.38 TRIO
 trio Rho guanine nucleotide exchange factor
 14359
 0.31
chr2_190118686_190118837 0.38 ENSG00000266817
 .
 57726
 0.13
chr8_116461452_116461961 0.38 TRPS1
 trichorhinophalangeal syndrome I
 42742
 0.19
chr18_53400073_53400224 0.38 TCF4
 transcription factor 4
 68130
 0.14
chr4_8527517_8527668 0.37 GPR78
 G protein-coupled receptor 78
 54701
 0.11
chr11_74031798_74031949 0.37 P4HA3
 prolyl 4-hydroxylase, alpha polypeptide III
 9171
 0.18
chr8_26469143_26469294 0.37 DPYSL2
 dihydropyrimidinase-like 2
 33297
 0.21
chr1_198227986_198228137 0.37 NEK7
 NIMA-related kinase 7
 38132
 0.23
chr1_6230966_6231267 0.37 CHD5
 chromodomain helicase DNA binding protein 5
 9067
 0.14
chr22_43263821_43263972 0.37 ARFGAP3
 ADP-ribosylation factor GTPase activating protein 3
 9784
 0.23
chr15_42578664_42578815 0.36 GANC
 glucosidase, alpha; neutral C
 12299
 0.16
chr11_129093775_129094069 0.36 ENSG00000199260
 .
 21061
 0.22
chr9_128223375_128223526 0.36 MAPKAP1
 mitogen-activated protein kinase associated protein 1
 23330
 0.21
chr2_46066755_46066906 0.36 PRKCE
 protein kinase C, epsilon
 161211
 0.04
chr9_128005655_128005806 0.36 RP11-65N13.8
1788
 0.26
chr1_186782472_186782623 0.36 PLA2G4A
 phospholipase A2, group IVA (cytosolic, calcium-dependent)
 15538
 0.29
chr2_109565955_109566106 0.36 EDAR
 ectodysplasin A receptor
 39695
 0.19
chr3_42068290_42068573 0.35 TRAK1
 trafficking protein, kinesin binding 1
 64131
 0.11
chr11_72680748_72681422 0.35 FCHSD2
 FCH and double SH3 domains 2
 18972
 0.22
chr1_61586786_61586937 0.35 RP4-802A10.1
3544
 0.28
chr16_48400227_48400867 0.35 SIAH1
 siah E3 ubiquitin protein ligase 1
 735
 0.66
chr4_108921158_108921309 0.35 HADH
 hydroxyacyl-CoA dehydrogenase
 4558
 0.22
chr11_34393224_34393428 0.35 ABTB2
 ankyrin repeat and BTB (POZ) domain containing 2
 13771
 0.25
chr8_129189248_129189490 0.35 ENSG00000221261
 .
 27007
 0.21
chr8_93552671_93552822 0.35 ENSG00000221172
 .
 94817
 0.09
chr15_40200299_40200575 0.35 GPR176
 G protein-coupled receptor 176
 11989
 0.15
chr6_89744532_89744683 0.34 ENSG00000223001
 .
 28802
 0.13
chr3_131448487_131448638 0.34 CPNE4
 copine IV
 195863
 0.03
chr10_75346559_75346987 0.34 USP54
 ubiquitin specific peptidase 54
 4323
 0.16
chr14_63940302_63940453 0.34 ENSG00000252463
 .
 4115
 0.18
chr4_178362396_178362599 0.34 AGA
 aspartylglucosaminidase
 1160
 0.46
chr9_123495391_123495542 0.34 MEGF9
 multiple EGF-like-domains 9
 18718
 0.21
chr14_50469321_50469915 0.34 C14orf182
 chromosome 14 open reading frame 182
 4620
 0.21
chr8_37639065_37639216 0.34 GPR124
 G protein-coupled receptor 124
 2569
 0.21
chr8_141607678_141608368 0.34 AGO2
 argonaute RISC catalytic component 2
 7964
 0.25

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 0.8 GO:0006983 ER overload response(GO:0006983)
0.1 0.2 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 0.2 GO:0021508 floor plate formation(GO:0021508)
0.1 0.2 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.2 GO:0033345 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0 0.2 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.2 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.2 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.0 0.2 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.2 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.0 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0072191 ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0 0.1 GO:0003078 obsolete regulation of natriuresis(GO:0003078)
0.0 0.1 GO:0060068 vagina development(GO:0060068)
0.0 0.1 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.2 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.1 GO:0032347 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0033023 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0 0.1 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.4 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.2 GO:0071501 SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0001865 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0055064 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.2 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.1 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.1 GO:0048343 paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0 0.1 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.3 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.1 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.1 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.0 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.0 GO:0014848 urinary tract smooth muscle contraction(GO:0014848)
0.0 0.0 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.4 GO:0090659 adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.0 0.1 GO:0048488 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.3 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.2 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.0 GO:0070340 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0046471 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0 0.1 GO:0032060 bleb assembly(GO:0032060)
0.0 0.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.1 GO:0055057 neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057)
0.0 0.1 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.0 GO:0072216 positive regulation of metanephros development(GO:0072216)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0070295 renal water absorption(GO:0070295)
0.0 0.1 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.1 GO:0042447 hormone catabolic process(GO:0042447)
0.0 0.1 GO:0060039 pericardium development(GO:0060039)
0.0 0.1 GO:0051957 positive regulation of glutamate secretion(GO:0014049) positive regulation of amino acid transport(GO:0051957)
0.0 0.1 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.0 GO:0009730 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.0 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.0 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.0 GO:0043558 regulation of translational initiation in response to stress(GO:0043558)
0.0 0.0 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.0 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0 0.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.0 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.2 GO:0050812 acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0 0.0 GO:0031394 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.0 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.0 0.0 GO:0032097 positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0 0.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.0 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.2 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.1 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.0 0.0 GO:0001973 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.0 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.1 GO:0030878 thyroid gland development(GO:0030878)
0.0 0.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.0 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.1 GO:0035246 peptidyl-arginine N-methylation(GO:0035246)
0.0 0.0 GO:0060014 granulosa cell differentiation(GO:0060014)
0.0 0.0 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.0 GO:0009648 photoperiodism(GO:0009648)
0.0 0.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.0 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.0 GO:0001696 gastric acid secretion(GO:0001696)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.0 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.0 0.1 GO:0034695 response to prostaglandin E(GO:0034695)
0.0 0.1 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.0 GO:0060426 lung vasculature development(GO:0060426)
0.0 0.1 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.0 GO:0032692 negative regulation of interleukin-1 production(GO:0032692)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.3 GO:0033268 node of Ranvier(GO:0033268)
0.1 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.2 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.2 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.0 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0071817 MMXD complex(GO:0071817)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.1 GO:0032838 cell projection cytoplasm(GO:0032838)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.0 GO:0031933 telomeric heterochromatin(GO:0031933)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.2 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.1 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.1 0.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 0.2 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.1 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.3 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 1.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0043295 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696) BMP receptor binding(GO:0070700)
0.0 0.0 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.0 GO:0097493 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.0 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.0 GO:0002060 nucleobase binding(GO:0002054) purine nucleobase binding(GO:0002060)
0.0 0.1 GO:0031545 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.0 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.0 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0048038 quinone binding(GO:0048038)
0.0 0.0 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0019841 retinol binding(GO:0019841)
0.0 0.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.0 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID AVB3 OPN PATHWAY Osteopontin-mediated events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.0 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.0 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.0 REACTOME SIGNALING BY FGFR1 MUTANTS Genes involved in Signaling by FGFR1 mutants
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors