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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for ATF5

Z-value: 1.61

Motif logo

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Transcription factors associated with ATF5

Gene Symbol Gene ID Gene Info
ATF5
ENSG00000169136.4 activating transcription factor 5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr19_50431904_50432210ATF5980.8058680.343.7e-01Click!
chr19_50427511_50427662ATF543730.077943-0.294.5e-01Click!
chr19_50426496_50426647ATF553880.073280-0.245.3e-01Click!
chr19_50427838_50427989ATF540460.080094-0.206.1e-01Click!
chr19_50433408_50433958ATF52070.703805-0.137.4e-01Click!

Activity of the ATF5 motif across conditions

Conditions sorted by the z-value of the ATF5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr3_194456835_194457137 0.82 FAM43A
 family with sequence similarity 43, member A
 50364
 0.11
chr22_37696225_37696376 0.70 CYTH4
 cytohesin 4
 9709
 0.17
chr12_62691099_62691281 0.59 USP15
 ubiquitin specific peptidase 15
 8186
 0.22
chr17_14215558_14215761 0.55 HS3ST3B1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
 11259
 0.27
chr5_36724502_36724744 0.53 CTD-2353F22.1
652
 0.82
chr11_9573412_9573568 0.52 WEE1
 WEE1 G2 checkpoint kinase
 21738
 0.13
chr12_106177631_106177796 0.51 NUAK1
 NUAK family, SNF1-like kinase, 1
 300098
 0.01
chr17_32706061_32706253 0.50 CCL1
 chemokine (C-C motif) ligand 1
 15907
 0.17
chr20_43996735_43996900 0.48 SYS1
 SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
 4723
 0.13
chr3_177142028_177142201 0.46 ENSG00000252028
 .
 79226
 0.12
chr16_8725990_8726202 0.46 METTL22
 methyltransferase like 22
 8899
 0.2
chr19_47226837_47226988 0.45 STRN4
 striatin, calmodulin binding protein 4
 444
 0.67
chr10_98416850_98417114 0.44 PIK3AP1
 phosphoinositide-3-kinase adaptor protein 1
 12386
 0.2
chr20_62492291_62492444 0.43 ABHD16B
 abhydrolase domain containing 16B
 199
 0.8
chr8_131217304_131217455 0.43 ASAP1
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
 24271
 0.21
chr1_66717796_66717947 0.41 PDE4B
 phosphodiesterase 4B, cAMP-specific
 5459
 0.33
chr13_41576792_41576957 0.41 ELF1
 E74-like factor 1 (ets domain transcription factor)
 16576
 0.19
chr18_21589322_21589666 0.40 TTC39C
 tetratricopeptide repeat domain 39C
 4890
 0.2
chr1_90222995_90223224 0.40 ENSG00000239176
 .
 10768
 0.21
chr1_36359399_36359646 0.40 AGO1
 argonaute RISC catalytic component 1
 10712
 0.2
chr9_7011676_7011831 0.39 KDM4C
 lysine (K)-specific demethylase 4C
 2035
 0.48
chr9_127455863_127456089 0.39 ENSG00000207737
 .
 13
 0.96
chr13_30950302_30950776 0.39 KATNAL1
 katanin p60 subunit A-like 1
 68918
 0.11
chr4_82413655_82413934 0.39 RASGEF1B
 RasGEF domain family, member 1B
 20725
 0.28
chr10_115082326_115082477 0.38 ENSG00000238380
 .
 30783
 0.24
chrX_65206607_65206882 0.38 RP6-159A1.3
12849
 0.22
chr17_66252375_66252526 0.37 ARSG
 arylsulfatase G
 2873
 0.21
chr9_92098673_92099046 0.37 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 4054
 0.27
chr2_145279915_145280210 0.37 ZEB2
 zinc finger E-box binding homeobox 2
 1441
 0.42
chr9_139947067_139947247 0.37 RP11-229P13.15
69
 0.89
chr1_162287658_162287874 0.37 RP11-565P22.2
182
 0.93
chr8_56837997_56838148 0.37 LYN
 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
 14721
 0.14
chr12_6753605_6754226 0.36 ACRBP
 acrosin binding protein
 2644
 0.12
chr17_55063294_55063526 0.36 RP5-1107A17.4
3300
 0.17
chr1_209931882_209932204 0.36 TRAF3IP3
 TRAF3 interacting protein 3
 200
 0.92
chr5_150599949_150600100 0.35 CCDC69
 coiled-coil domain containing 69
 3682
 0.22
chr3_119216680_119216943 0.35 TIMMDC1
 translocase of inner mitochondrial membrane domain containing 1
 568
 0.72
chr16_28505934_28506370 0.35 APOBR
 apolipoprotein B receptor
 159
 0.85
chr22_37333070_37333221 0.35 ENSG00000239056
 .
 11377
 0.12
chr3_135219068_135219244 0.34 ENSG00000253004
 .
 299466
 0.01
chr1_113589732_113590143 0.34 LRIG2
 leucine-rich repeats and immunoglobulin-like domains 2
 25894
 0.22
chr15_70628976_70629127 0.34 ENSG00000200216
 .
 143476
 0.05
chr9_140541223_140541390 0.34 EHMT1
 euchromatic histone-lysine N-methyltransferase 1
 27852
 0.12
chr3_101504132_101504283 0.33 NXPE3
 neurexophilin and PC-esterase domain family, member 3
 37
 0.97
chr20_4793040_4793193 0.33 RASSF2
 Ras association (RalGDS/AF-6) domain family member 2
 2653
 0.29
chrX_65222769_65222920 0.33 RP6-159A1.3
3251
 0.27
chr2_74175450_74175659 0.33 ENSG00000201876
 .
 19779
 0.14
chr14_35183268_35183419 0.33 CFL2
 cofilin 2 (muscle)
 99
 0.97
chr4_164529822_164529973 0.33 MARCH1
 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
 4789
 0.31
chr3_171779828_171780095 0.33 FNDC3B
 fibronectin type III domain containing 3B
 15258
 0.27
chr1_209930798_209930949 0.33 TRAF3IP3
 TRAF3 interacting protein 3
 970
 0.47
chr1_17449628_17449779 0.33 PADI2
 peptidyl arginine deiminase, type II
 3755
 0.22
chrX_17700747_17700898 0.33 NHS
 Nance-Horan syndrome (congenital cataracts and dental anomalies)
 47409
 0.15
chr12_4548368_4548657 0.33 FGF6
 fibroblast growth factor 6
 4873
 0.24
chr19_6958874_6959025 0.33 RP11-1137G4.3
5727
 0.16
chr12_63308633_63308784 0.33 PPM1H
 protein phosphatase, Mg2+/Mn2+ dependent, 1H
 20109
 0.2
chr7_81404438_81404589 0.32 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
 4759
 0.35
chr3_14693666_14694016 0.32 CCDC174
 coiled-coil domain containing 174
 570
 0.73
chr19_46005187_46005379 0.32 PPM1N
 protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
 2064
 0.19
chr8_8678347_8678544 0.32 MFHAS1
 malignant fibrous histiocytoma amplified sequence 1
 72710
 0.1
chr8_65776788_65776939 0.32 CYP7B1
 cytochrome P450, family 7, subfamily B, polypeptide 1
 65545
 0.14
chr9_115995100_115995251 0.32 SLC31A1
 solute carrier family 31 (copper transporter), member 1
 11333
 0.15
chr19_19271102_19271312 0.32 MEF2B
 myocyte enhancer factor 2B
 9847
 0.11
chr1_161180255_161180406 0.32 FCER1G
 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
 4739
 0.07
chr7_41379726_41379877 0.31 INHBA-AS1
 INHBA antisense RNA 1
 353713
 0.01
chr1_169597496_169597737 0.31 SELP
 selectin P (granule membrane protein 140kDa, antigen CD62)
 1698
 0.41
chr5_177959921_177960072 0.31 COL23A1
 collagen, type XXIII, alpha 1
 29243
 0.19
chr15_99499703_99499854 0.31 IGF1R
 insulin-like growth factor 1 receptor
 31949
 0.16
chr13_43744708_43744859 0.31 DNAJC15
 DnaJ (Hsp40) homolog, subfamily C, member 15
 147444
 0.05
chr19_52269762_52269913 0.31 FPR2
 formyl peptide receptor 2
 1794
 0.24
chr4_185819150_185819410 0.31 ENSG00000263458
 .
 40314
 0.14
chr22_17597863_17598182 0.31 CECR6
 cat eye syndrome chromosome region, candidate 6
 4121
 0.17
chr1_194039700_194039851 0.31 ENSG00000252241
 .
 338701
 0.01
chr6_135602284_135602577 0.31 RP3-388E23.2
20276
 0.17
chr6_138289503_138289940 0.31 RP11-356I2.4
100351
 0.07
chr2_7570361_7571021 0.31 ENSG00000221255
 .
 146281
 0.05
chr10_106010241_106010392 0.30 GSTO1
 glutathione S-transferase omega 1
 3636
 0.16
chr12_123284211_123284445 0.30 CCDC62
 coiled-coil domain containing 62
 18541
 0.13
chr21_43710315_43710466 0.30 ENSG00000216197
 .
 10065
 0.15
chr1_28320130_28320423 0.30 RP11-460I13.2
33572
 0.1
chr10_64519735_64519887 0.30 ADO
 2-aminoethanethiol (cysteamine) dioxygenase
 44705
 0.14
chr2_218884404_218884588 0.30 TNS1
 tensin 1
 16778
 0.16
chrX_147416060_147416261 0.30 AC002368.4
165975
 0.04
chr1_9303502_9303653 0.29 H6PD
 hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
 3674
 0.24
chr2_232334294_232334692 0.29 NCL
 nucleolin
 5188
 0.11
chr10_82355785_82355994 0.29 SH2D4B
 SH2 domain containing 4B
 55314
 0.14
chr10_7199881_7200167 0.29 SFMBT2
 Scm-like with four mbt domains 2
 250683
 0.02
chr1_17394434_17394729 0.29 SDHB
 succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
 13916
 0.17
chr10_134148263_134148414 0.29 LRRC27
 leucine rich repeat containing 27
 274
 0.91
chr5_156706986_156707255 0.29 CYFIP2
 cytoplasmic FMR1 interacting protein 2
 5252
 0.16
chr3_72679493_72679778 0.29 ENSG00000199469
 .
 53793
 0.13
chr11_127345243_127345408 0.29 ENSG00000223315
 .
 67579
 0.13
chr6_20068674_20068825 0.29 RP11-239H6.2
143569
 0.04
chr7_128709757_128710019 0.29 ENSG00000238733
 .
 8303
 0.17
chr1_169665494_169666108 0.29 SELL
 selectin L
 15038
 0.19
chr1_249101157_249101330 0.29 SH3BP5L
 SH3-binding domain protein 5-like
 10029
 0.16
chr19_52035107_52035430 0.29 SIGLEC6
 sialic acid binding Ig-like lectin 6
 158
 0.92
chr6_90793986_90794257 0.28 ENSG00000222078
 .
 82896
 0.09
chrX_70917357_70917654 0.28 ENSG00000221684
 .
 61800
 0.11
chrX_52950600_52950792 0.28 FAM156B
 family with sequence similarity 156, member B
 22287
 0.17
chr7_141360008_141360198 0.28 RP5-894A10.2
3493
 0.17
chr16_23870015_23870166 0.28 PRKCB
 protein kinase C, beta
 21546
 0.22
chr10_120488698_120489276 0.28 CACUL1
 CDK2-associated, cullin domain 1
 25771
 0.2
chr3_157161787_157162122 0.28 PTX3
 pentraxin 3, long
 7376
 0.26
chr7_5819044_5819195 0.28 RNF216
 ring finger protein 216
 2132
 0.31
chr3_17024083_17024265 0.28 PLCL2
 phospholipase C-like 2
 27812
 0.2
chr9_137826567_137827103 0.28 FCN1
 ficolin (collagen/fibrinogen domain containing) 1
 17026
 0.14
chr1_111433483_111434153 0.28 CD53
 CD53 molecule
 18042
 0.16
chr2_29223602_29224161 0.28 FAM179A
 family with sequence similarity 179, member A
 17246
 0.14
chr21_37884637_37884788 0.28 AP000695.1
26547
 0.16
chr1_160681902_160682094 0.28 CD48
 CD48 molecule
 357
 0.85
chr5_95674050_95674201 0.27 PCSK1
 proprotein convertase subtilisin/kexin type 1
 93739
 0.08
chr20_31096438_31096678 0.27 C20orf112
 chromosome 20 open reading frame 112
 2652
 0.27
chr1_206954843_206955128 0.27 IL10
 interleukin 10
 9146
 0.16
chr2_231526275_231526495 0.27 CAB39
 calcium binding protein 39
 51175
 0.12
chr2_8678901_8679157 0.27 AC011747.7
136867
 0.05
chrX_70279954_70280194 0.27 SNX12
 sorting nexin 12
 8179
 0.13
chr17_76907206_76907515 0.27 CTD-2373H9.5
8015
 0.14
chr1_146675568_146675782 0.27 FMO5
 flavin containing monooxygenase 5
 21226
 0.14
chr16_66264539_66264690 0.27 ENSG00000201999
 .
 71098
 0.11
chr20_47430189_47430589 0.27 PREX1
 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
 14031
 0.26
chr17_25857470_25857637 0.27 KSR1
 kinase suppressor of ras 1
 52394
 0.12
chr6_106896400_106896618 0.27 ENSG00000202386
 .
 747
 0.63
chr20_60487292_60487443 0.27 ENSG00000221417
 .
 41351
 0.17
chr8_21341059_21341347 0.27 ENSG00000266713
 .
 10336
 0.28
chr7_18184166_18184423 0.27 ENSG00000221393
 .
 17362
 0.24
chr1_198633904_198634162 0.27 RP11-553K8.5
2157
 0.39
chr5_39203706_39203857 0.27 FYB
 FYN binding protein
 652
 0.81
chr15_74285416_74285684 0.27 STOML1
 stomatin (EPB72)-like 1
 861
 0.47
chr5_114960864_114961097 0.27 TMED7-TICAM2
 TMED7-TICAM2 readthrough
 731
 0.35
chr1_108430883_108431034 0.27 VAV3-AS1
 VAV3 antisense RNA 1
 76107
 0.1
chr3_138501187_138501338 0.26 PIK3CB
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
 11865
 0.27
chr12_51155615_51155794 0.26 ATF1
 activating transcription factor 1
 1789
 0.35
chr16_88433_88739 0.26 SNRNP25
 small nuclear ribonucleoprotein 25kDa (U11/U12)
 14424
 0.09
chr9_90227526_90227781 0.26 DAPK1-IT1
 DAPK1 intronic transcript 1 (non-protein coding)
 59284
 0.13
chr8_96560843_96561107 0.26 ENSG00000202112
 .
 50367
 0.18
chrX_65220131_65220324 0.26 RP6-159A1.3
634
 0.76
chr21_36401379_36401530 0.26 RUNX1
 runt-related transcription factor 1
 20008
 0.29
chr6_109162800_109163213 0.26 ARMC2
 armadillo repeat containing 2
 6613
 0.28
chr7_79736267_79736525 0.26 GNAI1
 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
 26875
 0.25
chr10_6981008_6981159 0.26 PRKCQ
 protein kinase C, theta
 358820
 0.01
chr7_20510929_20511080 0.26 ENSG00000200753
 .
 94050
 0.08
chr7_37381820_37382186 0.26 ELMO1
 engulfment and cell motility 1
 364
 0.89
chr7_30200789_30200940 0.26 AC007036.5
3717
 0.21
chr2_90067763_90067914 0.26 IGKV6D-21
 immunoglobulin kappa variable 6D-21 (non-functional)
 7461
 0.07
chr7_105087983_105088187 0.25 SRPK2
 SRSF protein kinase 2
 58247
 0.11
chr10_6604152_6604623 0.25 PRKCQ
 protein kinase C, theta
 17814
 0.29
chr3_64823974_64824125 0.25 ADAMTS9
 ADAM metallopeptidase with thrombospondin type 1 motif, 9
 150373
 0.04
chr1_192667639_192667790 0.25 RGS13
 regulator of G-protein signaling 13
 62432
 0.13
chr12_15126426_15126577 0.25 PDE6H
 phosphodiesterase 6H, cGMP-specific, cone, gamma
 545
 0.75
chr13_46927202_46927353 0.25 ENSG00000223336
 .
 21448
 0.17
chr19_52598741_52598892 0.25 ZNF841
 zinc finger protein 841
 192
 0.91
chr2_143885609_143886070 0.25 ARHGAP15
 Rho GTPase activating protein 15
 1044
 0.64
chr20_8301190_8301355 0.25 PLCB1-IT1
 PLCB1 intronic transcript 1 (non-protein coding)
 71900
 0.13
chr21_39811436_39811587 0.25 ERG
 v-ets avian erythroblastosis virus E26 oncogene homolog
 58834
 0.15
chr7_5764998_5765171 0.25 RNF216-IT1
 RNF216 intronic transcript 1 (non-protein coding)
 44992
 0.12
chr2_44978729_44978880 0.25 ENSG00000252896
 .
 30465
 0.24
chr5_150480061_150480320 0.25 ANXA6
 annexin A6
 4643
 0.22
chr12_109213549_109213779 0.25 SSH1
 slingshot protein phosphatase 1
 6398
 0.16
chr10_7805763_7805973 0.25 KIN
 KIN, antigenic determinant of recA protein homolog (mouse)
 24076
 0.17
chr5_154350077_154350228 0.25 MRPL22
 mitochondrial ribosomal protein L22
 29490
 0.14
chr19_13319774_13320090 0.25 CACNA1A
 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
 48282
 0.08
chr21_45439617_45439889 0.25 TRAPPC10
 trafficking protein particle complex 10
 7553
 0.18
chr13_80452469_80452769 0.25 NDFIP2
 Nedd4 family interacting protein 2
 397031
 0.01
chr7_142429941_142430115 0.24 PRSS1
 protease, serine, 1 (trypsin 1)
 27291
 0.17
chr22_38438083_38438604 0.24 RP5-1039K5.16
8108
 0.11
chr11_75585074_75585225 0.24 UVRAG
 UV radiation resistance associated
 4299
 0.16
chr17_14096680_14097352 0.24 ENSG00000252305
 .
 16568
 0.19
chr2_113994292_113994443 0.24 ENSG00000189223
 .
 521
 0.65
chr9_86184099_86184307 0.24 ENSG00000199483
 .
 27296
 0.15
chr1_182182781_182183127 0.24 ENSG00000206764
 .
 113249
 0.06
chr5_176824252_176824525 0.24 PFN3
 profilin 3
 3249
 0.12
chr10_74612089_74612240 0.24 OIT3
 oncoprotein induced transcript 3
 41175
 0.15
chr14_75807156_75807307 0.24 FOS
 FBJ murine osteosarcoma viral oncogene homolog
 60335
 0.09
chr18_29636683_29636932 0.24 ENSG00000265063
 .
 4145
 0.17
chr1_207243907_207244203 0.24 PFKFB2
 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
 5706
 0.14
chr12_11874823_11874974 0.24 ETV6
 ets variant 6
 30537
 0.23
chr7_141565022_141565323 0.24 OR9A3P
 olfactory receptor, family 9, subfamily A, member 3 pseudogene
 2512
 0.17
chr11_10836352_10836503 0.24 RP11-685M7.3
5583
 0.14
chrX_65125867_65126018 0.24 RP6-159A1.3
93651
 0.08
chr14_91844279_91844530 0.24 CCDC88C
 coiled-coil domain containing 88C
 39286
 0.15
chr15_77707627_77707803 0.24 PEAK1
 pseudopodium-enriched atypical kinase 1
 4727
 0.25
chr18_24281825_24282055 0.24 ENSG00000265369
 .
 12447
 0.22
chr12_71401978_71402129 0.23 PTPRR
 protein tyrosine phosphatase, receptor type, R
 87430
 0.08
chr17_14233058_14233209 0.23 HS3ST3B1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
 28733
 0.23
chr13_72400590_72400741 0.23 DACH1
 dachshund homolog 1 (Drosophila)
 40242
 0.22
chr1_79111038_79111189 0.23 IFI44
 interferon-induced protein 44
 4403
 0.25
chr1_207095862_207096179 0.23 FAIM3
 Fas apoptotic inhibitory molecule 3
 521
 0.73
chr16_66619782_66620057 0.23 RP11-403P17.2
5300
 0.11
chr7_37706259_37706410 0.23 GPR141
 G protein-coupled receptor 141
 17066
 0.22
chr21_45774588_45774760 0.23 TRPM2
 transient receptor potential cation channel, subfamily M, member 2
 1103
 0.32
chr10_64394826_64394983 0.23 ZNF365
 zinc finger protein 365
 8629
 0.24
chr12_104894058_104894320 0.23 CHST11
 carbohydrate (chondroitin 4) sulfotransferase 11
 43410
 0.18
chrX_135064888_135065039 0.23 SLC9A6
 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
 2635
 0.27
chr3_196322790_196323004 0.23 FBXO45
 F-box protein 45
 27338
 0.1
chr18_54135220_54135371 0.23 TXNL1
 thioredoxin-like 1
 146427
 0.05
chr2_198099581_198099897 0.23 ANKRD44
 ankyrin repeat domain 44
 36977
 0.14
chr9_91927372_91927649 0.23 ENSG00000265112
 .
 370
 0.8
chr7_20510108_20510347 0.23 ENSG00000200753
 .
 93273
 0.08
chr6_139969651_139969888 0.23 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 274012
 0.02

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.3 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 0.2 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.1 0.2 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.1 GO:0045634 regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0 0.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.3 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 0.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.2 GO:0018101 protein citrullination(GO:0018101)
0.0 0.1 GO:2000143 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.0 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.1 GO:0048087 positive regulation of developmental pigmentation(GO:0048087)
0.0 0.3 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.6 GO:0045730 respiratory burst(GO:0045730)
0.0 0.1 GO:0030210 heparin biosynthetic process(GO:0030210)
0.0 0.2 GO:0048875 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.0 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 0.0 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.0 0.1 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:1903429 regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.2 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0031062 positive regulation of histone methylation(GO:0031062)
0.0 0.1 GO:1903020 positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0 0.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0061526 acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.2 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.1 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.1 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.4 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.0 GO:0061298 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.1 GO:0045341 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.0 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 0.4 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.1 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.2 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 0.1 GO:0032025 response to cobalt ion(GO:0032025)
0.0 0.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.4 GO:0032011 ARF protein signal transduction(GO:0032011)
0.0 0.2 GO:0050860 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.2 GO:0006911 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.1 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.0 GO:0014805 smooth muscle adaptation(GO:0014805)
0.0 0.1 GO:0033700 phospholipid efflux(GO:0033700)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.1 GO:0035067 negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0 0.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.1 GO:0034371 chylomicron remodeling(GO:0034371)
0.0 0.1 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.0 0.3 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.1 GO:0046618 drug export(GO:0046618)
0.0 0.1 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.0 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.0 0.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.0 GO:0002604 dendritic cell antigen processing and presentation(GO:0002468) regulation of dendritic cell antigen processing and presentation(GO:0002604) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.0 GO:0015809 arginine transport(GO:0015809)
0.0 0.1 GO:1901538 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 0.1 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:0060004 reflex(GO:0060004)
0.0 0.0 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.1 GO:0008653 lipopolysaccharide metabolic process(GO:0008653)
0.0 0.0 GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0 0.0 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.2 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.0 0.1 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:0016102 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0 0.1 GO:0036230 granulocyte activation(GO:0036230)
0.0 0.1 GO:0001302 replicative cell aging(GO:0001302)
0.0 0.1 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 0.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.0 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.0 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.1 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.0 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.1 GO:0006105 succinate metabolic process(GO:0006105)
0.0 0.0 GO:0003085 negative regulation of systemic arterial blood pressure(GO:0003085)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.0 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.0 0.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.1 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.1 GO:0000303 response to superoxide(GO:0000303)
0.0 0.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.0 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.0 0.0 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.0 0.1 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.1 GO:0009151 purine deoxyribonucleotide metabolic process(GO:0009151)
0.0 0.0 GO:1903224 endodermal cell fate commitment(GO:0001711) endodermal cell fate specification(GO:0001714) endodermal cell differentiation(GO:0035987) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.1 GO:0002437 inflammatory response to antigenic stimulus(GO:0002437)
0.0 0.1 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.3 GO:0045576 mast cell activation(GO:0045576)
0.0 0.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.1 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.0 0.1 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.1 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.2 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0 0.0 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.2 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.0 GO:0002438 acute inflammatory response to antigenic stimulus(GO:0002438)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0 0.1 GO:0008655 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0 0.0 GO:0042685 negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.0 0.0 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.0 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.0 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.1 GO:0046874 quinolinate metabolic process(GO:0046874)
0.0 0.1 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.1 GO:0032667 interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.0 0.0 GO:1901534 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.1 GO:0003341 cilium movement(GO:0003341)
0.0 0.0 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.1 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.0 GO:0051873 disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.0 0.0 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.1 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.1 GO:0032753 positive regulation of interleukin-4 production(GO:0032753)
0.0 0.1 GO:0031648 protein destabilization(GO:0031648)
0.0 0.0 GO:0044144 growth involved in symbiotic interaction(GO:0044110) growth of symbiont involved in interaction with host(GO:0044116) growth of symbiont in host(GO:0044117) regulation of growth of symbiont in host(GO:0044126) negative regulation of growth of symbiont in host(GO:0044130) modulation of growth of symbiont involved in interaction with host(GO:0044144) negative regulation of growth of symbiont involved in interaction with host(GO:0044146)
0.0 0.0 GO:0010613 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0 0.1 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.1 GO:0009595 detection of biotic stimulus(GO:0009595)
0.0 0.0 GO:1903115 regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0 0.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.1 GO:0032288 myelin assembly(GO:0032288)
0.0 0.1 GO:0051319 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.1 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.2 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.1 GO:0017085 response to insecticide(GO:0017085)
0.0 0.0 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.0 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.0 GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0 0.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0010829 negative regulation of glucose transport(GO:0010829) negative regulation of glucose import(GO:0046325)
0.0 0.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.0 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.0 GO:0060346 bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.0 0.1 GO:1901661 quinone metabolic process(GO:1901661)
0.0 0.0 GO:0015825 L-serine transport(GO:0015825)
0.0 0.0 GO:0010310 regulation of hydrogen peroxide metabolic process(GO:0010310)
0.0 0.0 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.0 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.0 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.0 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.3 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.1 GO:0010830 regulation of myotube differentiation(GO:0010830)
0.0 0.0 GO:0001821 histamine secretion(GO:0001821)
0.0 0.0 GO:0051657 maintenance of organelle location(GO:0051657)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0042827 platelet dense granule(GO:0042827)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.4 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.1 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)
0.0 0.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.3 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.0 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0030904 retromer complex(GO:0030904)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 0.1 GO:0031083 BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0 0.1 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.0 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.2 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0042627 chylomicron(GO:0042627)
0.0 0.0 GO:0001520 outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0 0.1 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.0 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.0 GO:0043159 acrosomal matrix(GO:0043159)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.0 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.0 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.0 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.2 GO:0043073 germ cell nucleus(GO:0043073)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 0.4 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1 0.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.2 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.1 0.2 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.1 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.2 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.1 GO:0032554 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.1 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0032357 single guanine insertion binding(GO:0032142) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357)
0.0 0.1 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.2 GO:0030553 cGMP binding(GO:0030553)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.6 GO:0003823 antigen binding(GO:0003823)
0.0 0.0 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.0 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.1 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.3 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.0 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.0 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.0 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0019864 IgG binding(GO:0019864)
0.0 0.0 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.2 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.0 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.1 GO:0003709 obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.1 GO:0004339 glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.0 0.1 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.0 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.1 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.6 GO:0008009 chemokine activity(GO:0008009)
0.0 0.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.0 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.0 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.0 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.0 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.0 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.0 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.0 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.0 GO:0004370 glycerol kinase activity(GO:0004370)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.0 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.0 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.0 0.1 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.0 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.6 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.1 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.0 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.0 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.0 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.0 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.1 GO:0015385 sodium:proton antiporter activity(GO:0015385)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.9 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.7 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.1 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.0 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.0 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.1 PID FOXO PATHWAY FoxO family signaling
0.0 0.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.0 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.1 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.0 PID GMCSF PATHWAY GMCSF-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.0 REACTOME CD28 CO STIMULATION Genes involved in CD28 co-stimulation
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.3 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.0 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.6 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.0 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
0.0 0.2 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.2 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.1 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.3 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.2 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network