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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for BACH2

Z-value: 0.74

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Transcription factors associated with BACH2

Gene Symbol	Gene ID	Gene Info
BACH2 Ensembl NCBI GeneCards UniProt	ENSG00000112182.10	BACH2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
BACH2	chr6_90981476_90981674	24886	0.218364	-0.90	1.0e-03	Click!
BACH2	chr6_90981736_90981993	24597	0.218974	-0.89	1.3e-03	Click!
BACH2	chr6_90982113_90982279	24265	0.219669	-0.86	2.6e-03	Click!
BACH2	chr6_90984432_90984583	21954	0.224353	-0.83	5.1e-03	Click!
BACH2	chr6_90951264_90951456	55101	0.146848	-0.82	6.5e-03	Click!

Activity of the BACH2 motif across conditions

Conditions sorted by the z-value of the BACH2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr22_18539696_18539847	0.49	XXbac-B476C20.9		20792	0.13
chr2_231481752_231482027	0.42	ENSG00000199791	.	30053	0.17
chr1_232845212_232845363	0.42	ENSG00000238382	.	9337	0.28
chr2_128155940_128156196	0.39	MAP3K2	mitogen-activated protein kinase kinase kinase 2	10027	0.16
chr2_110316196_110316465	0.38	AC011753.5		46945	0.13
chr4_8192745_8193409	0.38	SH3TC1	SH3 domain and tetratricopeptide repeats 1	8014	0.22
chr15_52393088_52393274	0.36	CTD-2184D3.5		461	0.77
chr2_43303091_43303242	0.35	ENSG00000207087	.	15466	0.28
chr19_39224351_39224502	0.35	CAPN12	calpain 12	1619	0.22
chr12_66089171_66089322	0.34	HMGA2	high mobility group AT-hook 2	128665	0.05
chr12_6388900_6389082	0.34	PLEKHG6	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	30611	0.12
chr8_145993953_145994104	0.34	ZNF34	zinc finger protein 34	11639	0.11
chr2_26235492_26235765	0.33	AC013449.1	Uncharacterized protein	15853	0.16
chr8_102038362_102038931	0.33	ENSG00000252736	.	63375	0.1
chr4_144276820_144277057	0.33	ENSG00000265623	.	12325	0.2
chr2_225544034_225544185	0.33	CUL3	cullin 3	93999	0.09
chr17_40561664_40561962	0.33	ENSG00000221020	.	10786	0.11
chr1_244437634_244437902	0.32	C1orf100	chromosome 1 open reading frame 100	78169	0.1
chr6_41680801_41681561	0.32	RP11-298J23.5		6953	0.13
chr12_56120404_56120555	0.32	CD63	CD63 molecule	364	0.7
chr4_10097090_10097875	0.31	ENSG00000264931	.	17166	0.14
chr11_58395317_58395468	0.30	CNTF	ciliary neurotrophic factor	5246	0.17
chr3_112500584_112500735	0.30	ENSG00000242770	.	20666	0.22
chr17_48128276_48128773	0.29	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	4815	0.16
chr19_16175455_16175640	0.29	TPM4	tropomyosin 4	2284	0.28
chr15_74688962_74689487	0.28	CYP11A1	cytochrome P450, family 11, subfamily A, polypeptide 1	29143	0.11
chr17_75118639_75118790	0.28	SEC14L1	SEC14-like 1 (S. cerevisiae)	5241	0.22
chr13_114524672_114524969	0.27	GAS6-AS1	GAS6 antisense RNA 1	6217	0.22
chr1_31229795_31230155	0.27	LAPTM5	lysosomal protein transmembrane 5	692	0.65
chr14_59827605_59828209	0.27	ENSG00000252869	.	38834	0.18
chr3_119854481_119854726	0.27	ENSG00000244139	.	13847	0.18
chr14_62052476_62052660	0.27	RP11-47I22.3	Uncharacterized protein	15254	0.21
chr15_74281262_74281725	0.27	STOML1	stomatin (EPB72)-like 1	2682	0.22
chr5_168521975_168522126	0.26	CTB-174D11.1		64607	0.13
chr13_33836245_33836396	0.26	ENSG00000236581	.	9196	0.23
chr1_1240872_1241150	0.26	ACAP3	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	2258	0.11
chr14_59895317_59895579	0.26	ENSG00000252869	.	28707	0.16
chr9_124044825_124044976	0.26	RP11-477J21.6		108	0.95
chr1_10519294_10519577	0.26	RP5-1113E3.3		823	0.46
chr16_70780334_70780534	0.26	RP11-394B2.6		526	0.69
chr5_148865258_148865409	0.25	CSNK1A1	casein kinase 1, alpha 1	27387	0.14
chr8_41655772_41655923	0.25	ANK1	ankyrin 1, erythrocytic	707	0.67
chr9_130326042_130326221	0.25	FAM129B	family with sequence similarity 129, member B	5236	0.19
chr17_29907812_29907963	0.25	ENSG00000199187	.	5457	0.13
chr5_14038564_14038715	0.25	DNAH5	dynein, axonemal, heavy chain 5	93987	0.09
chr1_10961180_10961385	0.25	C1orf127	chromosome 1 open reading frame 127	46645	0.12
chr5_65107256_65107407	0.25	NLN	neurolysin (metallopeptidase M3 family)	23141	0.22
chr1_10891158_10891309	0.25	CASZ1	castor zinc finger 1	34526	0.18
chr9_127457900_127458051	0.24	ENSG00000207737	.	1986	0.26
chr1_59491106_59491398	0.24	JUN	jun proto-oncogene	241467	0.02
chr6_10633412_10633876	0.24	GCNT6	glucosaminyl (N-acetyl) transferase 6	349	0.86
chr8_101774241_101774392	0.24	ENSG00000202001	.	6893	0.17
chr1_202557788_202557939	0.23	RP11-569A11.1		15533	0.2
chr15_79621555_79621707	0.23	ENSG00000266543	.	9441	0.2
chr21_43084452_43084603	0.23	LINC00112	long intergenic non-protein coding RNA 112	52069	0.12
chr22_37669382_37669767	0.23	CYTH4	cytohesin 4	8494	0.16
chr11_65259042_65259542	0.23	SCYL1	SCY1-like 1 (S. cerevisiae)	33256	0.08
chr7_137457647_137457798	0.23	DGKI	diacylglycerol kinase, iota	73560	0.12
chr6_100731277_100731428	0.23	RP1-121G13.2		143642	0.05
chr6_43090954_43091105	0.23	PTK7	protein tyrosine kinase 7	7300	0.13
chr22_27288381_27288532	0.23	ENSG00000200443	.	143394	0.05
chr5_149401334_149401630	0.23	ENSG00000238369	.	7533	0.14
chr13_109567579_109568598	0.23	MYO16	myosin XVI	29571	0.26
chr1_95163966_95164117	0.23	ENSG00000263526	.	47415	0.17
chr1_214731522_214731884	0.22	PTPN14	protein tyrosine phosphatase, non-receptor type 14	7137	0.28
chr8_143757384_143757535	0.22	PSCA	prostate stem cell antigen	4415	0.13
chr9_132007671_132007822	0.22	ENSG00000220992	.	14750	0.17
chr22_47330919_47331070	0.22	ENSG00000221672	.	87191	0.09
chr18_46463843_46464371	0.22	SMAD7	SMAD family member 7	10768	0.25
chr2_153271980_153272131	0.22	FMNL2	formin-like 2	80304	0.11
chr15_40577810_40578209	0.22	ANKRD63	ankyrin repeat domain 63	3222	0.12
chr1_154701622_154701930	0.22	ADAR	adenosine deaminase, RNA-specific	101302	0.05
chr4_148698718_148698869	0.22	ENSG00000264274	.	4953	0.21
chr3_48603652_48603803	0.22	UCN2	urocortin 2	2521	0.14
chr5_52105602_52106304	0.21	CTD-2288O8.1		22093	0.18
chr7_24826656_24826935	0.21	DFNA5	deafness, autosomal dominant 5	17551	0.26
chr17_2786695_2787071	0.21	CTD-3060P21.1		82306	0.07
chr2_238410967_238411392	0.21	MLPH	melanophilin	15260	0.18
chr11_9010825_9011174	0.21	NRIP3	nuclear receptor interacting protein 3	3696	0.14
chr2_60743198_60743767	0.21	AC009970.1		20661	0.21
chr1_27325551_27325702	0.21	TRNP1	TMF1-regulated nuclear protein 1	4816	0.17
chr17_28111866_28112121	0.21	ENSG00000252657	.	7356	0.17
chr5_153003729_153003880	0.21	ENSG00000242976	.	131138	0.05
chr19_49071957_49072108	0.21	SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	6765	0.11
chr21_33836630_33836895	0.21	EVA1C	eva-1 homolog C (C. elegans)	36120	0.13
chr21_38936455_38936763	0.21	AP001421.1	Uncharacterized protein	47869	0.16
chr21_38711029_38711180	0.21	AP001437.1		27130	0.16
chr6_107009204_107009507	0.21	AIM1	absent in melanoma 1	20326	0.18
chr16_57841238_57841389	0.21	CTD-2600O9.1	uncharacterized protein LOC388282	3236	0.18
chr20_3824293_3824586	0.21	MAVS	mitochondrial antiviral signaling protein	3048	0.18
chr2_169429731_169430128	0.21	ENSG00000265694	.	9524	0.23
chr5_176040795_176040946	0.21	GPRIN1	G protein regulated inducer of neurite outgrowth 1	3736	0.14
chr5_106767835_106767986	0.21	EFNA5	ephrin-A5	238418	0.02
chr5_159609192_159609343	0.21	FABP6	fatty acid binding protein 6, ileal	5107	0.2
chr6_158902774_158902925	0.20	ENSG00000243373	.	44020	0.14
chr11_130903385_130903536	0.20	ENSG00000242673	.	29136	0.23
chr14_75355002_75355210	0.20	DLST	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	6447	0.15
chr5_123932447_123932800	0.20	RP11-436H11.2		131901	0.05
chr20_52407741_52407914	0.20	ENSG00000238468	.	122530	0.05
chr16_10678700_10678851	0.20	EMP2	epithelial membrane protein 2	4220	0.21
chr5_14268148_14268359	0.20	TRIO	trio Rho guanine nucleotide exchange factor	22833	0.28
chr19_13163011_13163312	0.20	AC007787.2		19027	0.09
chr15_36720781_36720932	0.20	C15orf41	chromosome 15 open reading frame 41	150956	0.05
chr3_11642284_11642435	0.20	VGLL4	vestigial like 4 (Drosophila)	3696	0.24
chr12_132356722_132356873	0.20	ULK1	unc-51 like autophagy activating kinase 1	22399	0.14
chr15_71881190_71881341	0.20	THSD4	thrombospondin, type I, domain containing 4	41690	0.19
chr16_11295567_11296301	0.20	RMI2	RecQ mediated genome instability 2	47572	0.08
chr3_71651118_71651323	0.20	FOXP1	forkhead box P1	18080	0.2
chr5_135347184_135347335	0.20	TGFBI	transforming growth factor, beta-induced, 68kDa	17325	0.2
chr6_56526637_56526788	0.20	DST	dystonin	18918	0.28
chr12_24893513_24893767	0.19	ENSG00000240481	.	33918	0.21
chr12_124997368_124997619	0.19	NCOR2	nuclear receptor corepressor 2	5347	0.33
chr15_99664062_99664434	0.19	RP11-6O2.4		7763	0.14
chr10_29273394_29273655	0.19	ENSG00000199402	.	110088	0.07
chr14_103603313_103603536	0.19	TNFAIP2	tumor necrosis factor, alpha-induced protein 2	4339	0.2
chr11_104005552_104005703	0.19	PDGFD	platelet derived growth factor D	29208	0.23
chr7_55260410_55260561	0.19	EGFR-AS1	EGFR antisense RNA 1	3858	0.34
chr16_14404359_14404586	0.19	ENSG00000199130	.	1330	0.44
chr5_72969116_72969415	0.19	ARHGEF28	Rho guanine nucleotide exchange factor (GEF) 28	11392	0.24
chr10_70982539_70983066	0.19	HKDC1	hexokinase domain containing 1	2743	0.22
chr2_110859211_110859419	0.19	MALL	mal, T-cell differentiation protein-like	14284	0.15
chr9_84174156_84174449	0.19	TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	54135	0.17
chr5_148513977_148514128	0.19	ABLIM3	actin binding LIM protein family, member 3	6994	0.18
chr17_47533894_47534339	0.19	NGFR	nerve growth factor receptor	38539	0.1
chr18_21978734_21978885	0.19	OSBPL1A	oxysterol binding protein-like 1A	986	0.48
chr1_155223556_155224415	0.19	FAM189B	family with sequence similarity 189, member B	714	0.38
chr18_10035524_10035675	0.19	ENSG00000263630	.	30405	0.21
chr15_67467838_67468111	0.19	SMAD3	SMAD family member 3	9105	0.22
chr19_4794956_4795151	0.19	AC005523.2		514	0.66
chr16_88298714_88299235	0.19	ZNF469	zinc finger protein 469	194905	0.02
chr20_34673805_34674098	0.19	EPB41L1	erythrocyte membrane protein band 4.1-like 1	5475	0.21
chr9_127023759_127023910	0.19	NEK6	NIMA-related kinase 6	82	0.83
chr7_91476158_91476309	0.19	MTERF	mitochondrial transcription termination factor	33744	0.22
chr19_16174815_16174966	0.19	TPM4	tropomyosin 4	2941	0.24
chr18_59658543_59658754	0.18	RNF152	ring finger protein 152	97184	0.08
chr12_68958912_68959888	0.18	RAP1B	RAP1B, member of RAS oncogene family	45219	0.16
chr2_29850371_29850522	0.18	ENSG00000242699	.	53743	0.16
chr22_41961672_41961960	0.18	CSDC2	cold shock domain containing C2, RNA binding	5049	0.14
chr1_200746157_200746308	0.18	CAMSAP2	calmodulin regulated spectrin-associated protein family, member 2	37325	0.18
chr18_55758646_55758797	0.18	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	44263	0.17
chr9_113515310_113515461	0.18	MUSK	muscle, skeletal, receptor tyrosine kinase	22242	0.25
chr5_141742469_141742735	0.18	AC005592.2		9494	0.25
chr7_155088256_155088792	0.18	INSIG1	insulin induced gene 1	962	0.62
chr15_52369332_52369483	0.18	CTD-2184D3.5		23313	0.13
chr22_47226754_47226905	0.18	ENSG00000221672	.	16974	0.22
chr12_112741045_112741373	0.18	ENSG00000201428	.	36328	0.15
chr11_93470751_93471427	0.18	ENSG00000210825	.	2687	0.08
chr2_43152306_43152732	0.18	HAAO	3-hydroxyanthranilate 3,4-dioxygenase	132787	0.05
chr4_148752956_148753135	0.18	ENSG00000240014	.	22968	0.19
chr19_18681741_18681892	0.18	UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1	724	0.4
chr19_49071674_49071825	0.18	SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	7048	0.11
chr1_114665539_114665690	0.18	SYT6	synaptotagmin VI	29448	0.22
chr19_38794620_38794771	0.18	C19orf33	chromosome 19 open reading frame 33	106	0.92
chr17_42622509_42622660	0.18	FZD2	frizzled family receptor 2	12341	0.18
chr9_16204302_16204453	0.18	C9orf92	chromosome 9 open reading frame 92	11520	0.31
chr9_135506787_135506938	0.18	DDX31	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	32025	0.15
chr10_6261359_6261510	0.18	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	1933	0.3
chr1_26610395_26611734	0.18	SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	4451	0.13
chr6_130023402_130023553	0.18	ARHGAP18	Rho GTPase activating protein 18	7893	0.27
chr2_39869646_39869797	0.18	TMEM178A	transmembrane protein 178A	23338	0.24
chr9_97682173_97682324	0.18	RP11-54O15.3		14980	0.17
chr2_25570321_25570568	0.17	DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	4985	0.24
chr18_74452398_74452589	0.17	ENSG00000252097	.	60237	0.13
chr18_8122134_8122285	0.17	PTPRM	protein tyrosine phosphatase, receptor type, M	8640	0.24
chr19_576051_576313	0.17	BSG	basigin (Ok blood group)	961	0.34
chr2_235586595_235586746	0.17	ARL4C	ADP-ribosylation factor-like 4C	180973	0.03
chr16_9141478_9141964	0.17	C16orf72	chromosome 16 open reading frame 72	43784	0.12
chr22_46402793_46403252	0.17	WNT7B	wingless-type MMTV integration site family, member 7B	30013	0.1
chr20_25290765_25291165	0.17	ABHD12	abhydrolase domain containing 12	831	0.64
chr5_10555649_10555800	0.17	ANKRD33B	ankyrin repeat domain 33B	8856	0.2
chr8_37373070_37373278	0.17	RP11-150O12.6		1365	0.56
chr8_71125713_71126274	0.17	NCOA2	nuclear receptor coactivator 2	31617	0.21
chr15_59460757_59460908	0.17	ENSG00000253030	.	2629	0.17
chr5_109201537_109201688	0.17	AC011366.3	Uncharacterized protein	17271	0.29
chr18_9743354_9743731	0.17	RAB31	RAB31, member RAS oncogene family	35380	0.17
chr2_20696028_20696179	0.17	ENSG00000200829	.	15498	0.21
chr4_53791904_53792055	0.17	RP11-752D24.2		19837	0.23
chr4_48175111_48175594	0.17	ENSG00000202014	.	19901	0.18
chr11_69069206_69069429	0.17	MYEOV	myeloma overexpressed	7692	0.29
chr17_78801730_78801881	0.17	RP11-28G8.1		22373	0.2
chr1_17525565_17525716	0.17	PADI1	peptidyl arginine deiminase, type I	5981	0.19
chr2_206599303_206599570	0.17	AC007362.3		29241	0.21
chr16_4994791_4994942	0.17	ENSG00000200980	.	7026	0.15
chr1_41568152_41568303	0.17	SCMH1	sex comb on midleg homolog 1 (Drosophila)	57378	0.13
chr5_14165682_14165833	0.17	TRIO	trio Rho guanine nucleotide exchange factor	18150	0.3
chr2_20696298_20696449	0.17	ENSG00000200829	.	15768	0.21
chr22_44756801_44756952	0.17	RP1-32I10.10	Uncharacterized protein	4555	0.29
chr17_60780537_60780688	0.17	RP11-156L14.1		2955	0.22
chr12_52074390_52074541	0.17	SCN8A	sodium channel, voltage gated, type VIII, alpha subunit	5742	0.28
chr1_222060065_222060216	0.17	ENSG00000200033	.	49361	0.18
chr2_47420449_47420733	0.17	CALM2	calmodulin 2 (phosphorylase kinase, delta)	16851	0.2
chr8_22779071_22779222	0.17	PEBP4	phosphatidylethanolamine-binding protein 4	6275	0.16
chr12_117039449_117039758	0.17	MAP1LC3B2	microtubule-associated protein 1 light chain 3 beta 2	25947	0.23
chr20_19601854_19602005	0.16	ENSG00000216017	.	31098	0.2
chr16_4368044_4368195	0.16	GLIS2	GLIS family zinc finger 2	3357	0.17
chr7_35635806_35635957	0.16	HERPUD2	HERPUD family member 2	98295	0.08
chr4_102077826_102078189	0.16	ENSG00000221265	.	173564	0.03
chr5_14268406_14268609	0.16	TRIO	trio Rho guanine nucleotide exchange factor	22579	0.28
chr12_77425511_77425662	0.16	E2F7	E2F transcription factor 7	18940	0.27
chr3_196001577_196001860	0.16	PCYT1A	phosphate cytidylyltransferase 1, choline, alpha	4306	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of BACH2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0018101	protein citrullination(GO:0018101)
0.1	0.2	GO:0030011	maintenance of cell polarity(GO:0030011)
0.1	0.2	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.2	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.0	0.3	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0032933	SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0090190	positive regulation of mesonephros development(GO:0061213) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.1	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.1	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.1	GO:0051142	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.2	GO:0018214	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0032469	endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.0	0.1	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.0	GO:0048680	positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0	0.0	GO:0061072	iris morphogenesis(GO:0061072)
0.0	0.1	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.0	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.0	GO:1903672	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.0	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.0	GO:0090594	wound healing involved in inflammatory response(GO:0002246) inflammatory response to wounding(GO:0090594)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.0	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.0	GO:0090281	negative regulation of calcium ion import(GO:0090281)
0.0	0.1	GO:0031958	corticosteroid receptor signaling pathway(GO:0031958) glucocorticoid receptor signaling pathway(GO:0042921)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.1	GO:0000959	mitochondrial RNA metabolic process(GO:0000959) transcription from mitochondrial promoter(GO:0006390)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.0	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.1	GO:0021535	cell migration in hindbrain(GO:0021535)
0.0	0.0	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.0	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0002327	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.0	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0031125	rRNA 3'-end processing(GO:0031125)
0.0	0.0	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.0	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:0021819	layer formation in cerebral cortex(GO:0021819)
0.0	0.2	GO:0045103	intermediate filament-based process(GO:0045103)
0.0	0.0	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.0	GO:0060087	relaxation of smooth muscle(GO:0044557) relaxation of vascular smooth muscle(GO:0060087)
0.0	0.0	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0003099	positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0046689	response to mercury ion(GO:0046689)
0.0	0.1	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.0	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.2	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
0.0	0.0	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.0	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.0	GO:0005997	xylulose metabolic process(GO:0005997)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.2	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	GO:0030056	hemidesmosome(GO:0030056)
0.1	GO:0043260	laminin-11 complex(GO:0043260)
0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	GO:0032591	dendritic spine membrane(GO:0032591)
0.1	GO:0016342	catenin complex(GO:0016342)
0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	GO:0005593	FACIT collagen trimer(GO:0005593)
0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	GO:0033268	node of Ranvier(GO:0033268)
0.1	GO:0005587	collagen type IV trimer(GO:0005587)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.2	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:1901474	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.0	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.0	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.0	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.0	0.1	GO:0034739	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.0	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0045502	dynein binding(GO:0045502)
0.0	0.2	GO:0019894	kinesin binding(GO:0019894)
0.0	0.0	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.0	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.0	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.1	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.0	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.1	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	PID TRAIL PATHWAY	TRAIL signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.1	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.3	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.3	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism