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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for CDX2

Z-value: 0.69

Motif logo

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Transcription factors associated with CDX2

Gene Symbol Gene ID Gene Info
CDX2
ENSG00000165556.9 CDX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
CDX2chr13_28553030_2855318178290.1440250.722.8e-02Click!
CDX2chr13_28542993_2854320721760.2361050.684.4e-02Click!
CDX2chr13_28542609_2854284625490.2115480.665.5e-02Click!
CDX2chr13_28534615_28535489102240.1365550.655.6e-02Click!
CDX2chr13_28535904_2853605592970.1385590.655.8e-02Click!

Activity of the CDX2 motif across conditions

Conditions sorted by the z-value of the CDX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr2_109582380_109582745 0.38 EDAR
 ectodysplasin A receptor
 23163
 0.25
chr1_81780447_81780600 0.27 LPHN2
 latrophilin 2
 8672
 0.29
chr1_101437966_101438267 0.26 SLC30A7
 solute carrier family 30 (zinc transporter), member 7
 10732
 0.14
chr8_66861197_66861965 0.26 DNAJC5B
 DnaJ (Hsp40) homolog, subfamily C, member 5 beta
 72214
 0.11
chr5_122865285_122865436 0.26 CSNK1G3
 casein kinase 1, gamma 3
 15749
 0.23
chr6_12037649_12037832 0.23 HIVEP1
 human immunodeficiency virus type I enhancer binding protein 1
 21920
 0.24
chr1_160230794_160231302 0.22 RP11-574F21.2
486
 0.45
chr5_175974700_175974851 0.22 ENSG00000243959
 .
 48
 0.95
chr2_48543908_48544266 0.22 FOXN2
 forkhead box N2
 2238
 0.35
chr12_111613238_111613505 0.22 CUX2
 cut-like homeobox 2
 76121
 0.1
chr3_69508196_69508347 0.21 FRMD4B
 FERM domain containing 4B
 72841
 0.13
chr4_143621409_143621560 0.21 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 139662
 0.05
chr10_82251750_82251998 0.20 TSPAN14
 tetraspanin 14
 32816
 0.15
chr1_6652266_6652423 0.20 KLHL21
 kelch-like family member 21
 7532
 0.11
chr6_11258753_11259646 0.20 NEDD9
 neural precursor cell expressed, developmentally down-regulated 9
 26284
 0.22
chrX_64946026_64946177 0.20 MSN
 moesin
 58564
 0.16
chr8_66864395_66864582 0.20 DNAJC5B
 DnaJ (Hsp40) homolog, subfamily C, member 5 beta
 69307
 0.12
chr8_96157942_96158334 0.19 PLEKHF2
 pleckstrin homology domain containing, family F (with FYVE domain) member 2
 11834
 0.21
chr4_175618125_175618276 0.19 GLRA3
 glycine receptor, alpha 3
 132178
 0.05
chr1_116673236_116673387 0.19 MAB21L3
 mab-21-like 3 (C. elegans)
 18935
 0.25
chr18_3010170_3010321 0.19 LPIN2
 lipin 2
 1700
 0.33
chr2_9683437_9683847 0.19 ENSG00000238462
 .
 11168
 0.16
chr4_141164391_141164692 0.18 SCOC
 short coiled-coil protein
 13899
 0.21
chr14_44060665_44060966 0.18 FSCB
 fibrous sheath CABYR binding protein
 915667
 0.0
chr12_93638767_93638982 0.18 ENSG00000238361
 .
 20634
 0.16
chr12_11821489_11821646 0.18 ETV6
 ets variant 6
 18779
 0.25
chr10_89850893_89851084 0.18 ENSG00000200891
 .
 96536
 0.08
chr14_38546372_38546618 0.18 CTD-2058B24.2
13868
 0.25
chr4_36243199_36243543 0.18 ARAP2
 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
 2190
 0.3
chr2_68404077_68404429 0.17 RP11-474G23.2
2712
 0.22
chr15_92455349_92455602 0.17 SLCO3A1
 solute carrier organic anion transporter family, member 3A1
 58124
 0.15
chr21_16056596_16056882 0.17 AF165138.7
 Protein LOC388813
 25597
 0.23
chr5_158526590_158526785 0.17 EBF1
 early B-cell factor 1
 14
 0.99
chr9_126664569_126664720 0.17 DENND1A
 DENN/MADD domain containing 1A
 27742
 0.2
chr1_14035183_14035334 0.17 PRDM2
 PR domain containing 2, with ZNF domain
 3908
 0.25
chr2_120685704_120685855 0.17 PTPN4
 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
 1573
 0.44
chr1_100911531_100911742 0.17 RP5-837M10.4
39917
 0.15
chr2_145128325_145128476 0.17 GTDC1
 glycosyltransferase-like domain containing 1
 38317
 0.2
chr2_48545707_48546468 0.17 FOXN2
 forkhead box N2
 4238
 0.26
chr10_126409005_126409284 0.17 FAM53B-AS1
 FAM53B antisense RNA 1
 16391
 0.17
chr1_108440044_108440852 0.17 VAV3-AS1
 VAV3 antisense RNA 1
 66617
 0.11
chr13_77318791_77318984 0.17 KCTD12
 potassium channel tetramerization domain containing 12
 141638
 0.05
chr10_101942748_101942988 0.17 ERLIN1
 ER lipid raft associated 1
 2918
 0.19
chr2_12849849_12850137 0.17 TRIB2
 tribbles pseudokinase 2
 7022
 0.27
chr1_81673664_81673948 0.16 ENSG00000223026
 .
 43668
 0.2
chr17_28658400_28658590 0.16 TMIGD1
 transmembrane and immunoglobulin domain containing 1
 2570
 0.19
chr7_127749161_127749327 0.16 ENSG00000207588
 .
 27331
 0.2
chr15_31643081_31643271 0.16 KLF13
 Kruppel-like factor 13
 11040
 0.3
chr4_2487124_2487508 0.16 RNF4
 ring finger protein 4
 4222
 0.21
chr14_91479889_91480344 0.16 RPS6KA5
 ribosomal protein S6 kinase, 90kDa, polypeptide 5
 46362
 0.13
chr16_81530462_81530613 0.16 CMIP
 c-Maf inducing protein
 1583
 0.51
chr14_75735225_75735582 0.16 RP11-293M10.1
 Uncharacterized protein
 583
 0.61
chr1_89751943_89752616 0.16 GBP5
 guanylate binding protein 5
 13735
 0.19
chr11_46366304_46366455 0.16 DGKZ
 diacylglycerol kinase, zeta
 438
 0.79
chr2_174763218_174763492 0.16 SP3
 Sp3 transcription factor
 65592
 0.15
chr9_20256564_20257102 0.16 ENSG00000221744
 .
 38169
 0.2
chr2_152144415_152144634 0.16 NMI
 N-myc (and STAT) interactor
 1884
 0.36
chr11_128532326_128532477 0.16 RP11-744N12.3
23922
 0.16
chr2_65286677_65286830 0.16 CEP68
 centrosomal protein 68kDa
 3154
 0.23
chr5_86377835_86378358 0.16 ENSG00000251951
 .
 20567
 0.22
chr2_172950128_172950279 0.16 DLX1
 distal-less homeobox 1
 61
 0.98
chr16_67398247_67398398 0.16 LRRC36
 leucine rich repeat containing 36
 17016
 0.09
chr1_204429917_204430068 0.16 PIK3C2B
 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
 6482
 0.2
chr14_23631200_23631351 0.16 ENSG00000202229
 .
 5652
 0.12
chr16_55608208_55608359 0.16 CAPNS2
 calpain, small subunit 2
 7699
 0.24
chr19_36420808_36421170 0.15 LRFN3
 leucine rich repeat and fibronectin type III domain containing 3
 5463
 0.1
chr6_13724081_13724232 0.15 RANBP9
 RAN binding protein 9
 12360
 0.2
chr22_40877098_40877463 0.15 MKL1
 megakaryoblastic leukemia (translocation) 1
 17842
 0.16
chr14_50547578_50547939 0.15 ENSG00000251792
 .
 5942
 0.16
chr6_25432681_25432832 0.15 ENSG00000238322
 .
 2752
 0.28
chr14_91837471_91837667 0.15 ENSG00000265856
 .
 37512
 0.16
chr3_156534966_156535117 0.15 LEKR1
 leucine, glutamate and lysine rich 1
 9048
 0.29
chr3_16984029_16984180 0.15 ENSG00000264818
 .
 9416
 0.23
chr14_64226726_64226897 0.15 ENSG00000252749
 .
 23649
 0.17
chr5_49735595_49735840 0.15 EMB
 embigin
 1467
 0.6
chr2_99312607_99313038 0.15 MGAT4A
 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
 30337
 0.18
chr20_49132969_49133129 0.15 PTPN1
 protein tyrosine phosphatase, non-receptor type 1
 6129
 0.18
chr11_95940500_95940805 0.15 ENSG00000266192
 .
 133950
 0.05
chr3_183893854_183894036 0.15 AP2M1
 adaptor-related protein complex 2, mu 1 subunit
 621
 0.57
chr10_129856180_129856415 0.15 PTPRE
 protein tyrosine phosphatase, receptor type, E
 10463
 0.28
chr11_60047431_60047582 0.15 MS4A4A
 membrane-spanning 4-domains, subfamily A, member 4A
 508
 0.79
chr13_74576794_74576945 0.15 KLF12
 Kruppel-like factor 12
 7683
 0.34
chr12_833209_833360 0.15 WNK1
 WNK lysine deficient protein kinase 1
 28475
 0.16
chr3_46973999_46974150 0.15 PTH1R
 parathyroid hormone 1 receptor
 29985
 0.12
chr3_171457874_171458025 0.15 PLD1
 phospholipase D1, phosphatidylcholine-specific
 31200
 0.18
chr20_58714259_58714410 0.15 C20orf197
 chromosome 20 open reading frame 197
 83354
 0.1
chr12_96426880_96427227 0.15 LTA4H
 leukotriene A4 hydrolase
 2386
 0.24
chr6_4905786_4905958 0.15 CDYL
 chromodomain protein, Y-like
 15646
 0.26
chr17_76168269_76168420 0.15 SYNGR2
 synaptogyrin 2
 3105
 0.14
chr2_44408551_44408985 0.15 PPM1B
 protein phosphatase, Mg2+/Mn2+ dependent, 1B
 12719
 0.17
chr1_92057392_92057549 0.15 CDC7
 cell division cycle 7
 90775
 0.09
chr13_107145729_107145927 0.15 EFNB2
 ephrin-B2
 41634
 0.2
chr15_67535265_67535775 0.15 AAGAB
 alpha- and gamma-adaptin binding protein
 311
 0.91
chr1_198581769_198581966 0.15 PTPRC
 protein tyrosine phosphatase, receptor type, C
 25934
 0.21
chr1_117359843_117360063 0.15 CD2
 CD2 molecule
 62864
 0.1
chr19_35702667_35702989 0.15 FAM187B
 family with sequence similarity 187, member B
 16804
 0.09
chr19_42278293_42278624 0.14 AC011513.4
12343
 0.12
chr2_86413845_86413996 0.14 ENSG00000265420
 .
 6311
 0.13
chr11_46535797_46536138 0.14 ENSG00000265014
 .
 62528
 0.09
chr9_8622087_8622238 0.14 RP11-134K1.3
79390
 0.11
chr3_151974069_151974416 0.14 MBNL1
 muscleblind-like splicing regulator 1
 11587
 0.22
chr7_105713662_105713813 0.14 SYPL1
 synaptophysin-like 1
 24571
 0.22
chr12_54422690_54422841 0.14 HOXC6
 homeobox C6
 623
 0.45
chr7_7689968_7690119 0.14 RPA3
 replication protein A3, 14kDa
 9440
 0.26
chr11_13482552_13482719 0.14 BTBD10
 BTB (POZ) domain containing 10
 2093
 0.38
chr7_75057844_75058027 0.14 POM121C
 POM121 transmembrane nucleoporin C
 12044
 0.11
chr15_60085307_60085458 0.14 BNIP2
 BCL2/adenovirus E1B 19kDa interacting protein 2
 103649
 0.06
chr13_48758888_48759039 0.14 ITM2B
 integral membrane protein 2B
 48331
 0.15
chr22_47176191_47176342 0.14 TBC1D22A
 TBC1 domain family, member 22A
 6442
 0.21
chr12_31903224_31903375 0.14 AMN1
 antagonist of mitotic exit network 1 homolog (S. cerevisiae)
 21191
 0.15
chr4_16124268_16124434 0.14 PROM1
 prominin 1
 38350
 0.16
chr3_3149713_3149864 0.14 IL5RA
 interleukin 5 receptor, alpha
 1876
 0.29
chr3_121715323_121715474 0.14 ILDR1
 immunoglobulin-like domain containing receptor 1
 10750
 0.19
chr9_71459553_71459704 0.14 RP11-203L2.4
1437
 0.5
chr4_101351551_101351881 0.14 EMCN
 endomucin
 44518
 0.2
chr16_53495579_53495893 0.14 RBL2
 retinoblastoma-like 2 (p130)
 11748
 0.16
chr1_167198816_167199102 0.14 POU2F1
 POU class 2 homeobox 1
 8816
 0.19
chr18_72344613_72344764 0.14 ZNF407
 zinc finger protein 407
 1712
 0.5
chr7_72705268_72705440 0.14 GTF2IRD2P1
 GTF2I repeat domain containing 2 pseudogene 1
 11211
 0.14
chr14_71466068_71466359 0.14 PCNX
 pecanex homolog (Drosophila)
 13535
 0.29
chr10_6644457_6644608 0.14 PRKCQ
 protein kinase C, theta
 22269
 0.28
chr1_38657052_38657335 0.14 ENSG00000265596
 .
 102290
 0.06
chr1_202760210_202760361 0.14 KDM5B
 lysine (K)-specific demethylase 5B
 16142
 0.13
chr13_52390546_52391185 0.14 RP11-327P2.5
12432
 0.19
chr12_104865091_104865422 0.14 CHST11
 carbohydrate (chondroitin 4) sulfotransferase 11
 14477
 0.26
chr3_186763060_186763211 0.14 ST6GAL1
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
 1604
 0.46
chr6_152269471_152269669 0.14 ESR1
 estrogen receptor 1
 67778
 0.13
chr11_116870995_116871424 0.14 ENSG00000264344
 .
 15036
 0.16
chr2_161946247_161946703 0.14 TANK
 TRAF family member-associated NFKB activator
 46944
 0.17
chr7_20826220_20826440 0.14 SP8
 Sp8 transcription factor
 175
 0.97
chr16_27650621_27650772 0.14 AC002551.1
3824
 0.23
chr2_213832657_213832808 0.14 ENSG00000266354
 .
 41751
 0.18
chr7_37431624_37431775 0.13 ENSG00000200113
 .
 27532
 0.16
chr20_1475362_1475513 0.13 SIRPB2
 signal-regulatory protein beta 2
 3310
 0.17
chr18_56355165_56355674 0.13 RP11-126O1.4
10573
 0.15
chr1_212111630_212111803 0.13 ENSG00000212187
 .
 87187
 0.07
chr14_103908821_103908972 0.13 MARK3
 MAP/microtubule affinity-regulating kinase 3
 23155
 0.14
chr21_19153681_19154154 0.13 AL109761.5
11888
 0.23
chr6_106969864_106970230 0.13 AIM1
 absent in melanoma 1
 10317
 0.2
chr5_39185830_39185981 0.13 FYB
 FYN binding protein
 17224
 0.25
chr2_70779527_70779756 0.13 TGFA
 transforming growth factor, alpha
 981
 0.62
chr2_219031375_219031607 0.13 CXCR1
 chemokine (C-X-C motif) receptor 1
 227
 0.91
chr5_75565842_75566100 0.13 RP11-466P24.6
41316
 0.2
chr6_7439816_7439967 0.13 CAGE1
 cancer antigen 1
 49915
 0.13
chr11_77182415_77182566 0.13 DKFZP434E1119
1926
 0.31
chr5_179513527_179513811 0.13 RNF130
 ring finger protein 130
 14551
 0.2
chr15_52060726_52060931 0.13 CTD-2308G16.1
16146
 0.13
chr2_197022675_197023058 0.13 STK17B
 serine/threonine kinase 17b
 1495
 0.42
chr3_20093122_20093273 0.13 KAT2B
 K(lysine) acetyltransferase 2B
 11682
 0.19
chr13_99872623_99872781 0.13 ENSG00000201793
 .
 14740
 0.17
chr8_38226618_38226769 0.13 WHSC1L1
 Wolf-Hirschhorn syndrome candidate 1-like 1
 11646
 0.12
chr13_27975238_27975401 0.13 ENSG00000201242
 .
 1405
 0.39
chr14_99730566_99730874 0.13 AL109767.1
1435
 0.45
chr11_36402058_36402209 0.13 PRR5L
 proline rich 5 like
 3061
 0.26
chr5_98261626_98261777 0.13 CHD1
 chromodomain helicase DNA binding protein 1
 539
 0.8
chr11_36429123_36429289 0.13 PRR5L
 proline rich 5 like
 6591
 0.2
chr5_94891308_94891836 0.13 ARSK
 arylsulfatase family, member K
 701
 0.47
chr5_108991988_108992139 0.13 ENSG00000266090
 .
 29218
 0.18
chr5_167570316_167570766 0.13 CTB-178M22.1
44183
 0.16
chr9_134532062_134532585 0.13 RAPGEF1
 Rap guanine nucleotide exchange factor (GEF) 1
 30988
 0.18
chr6_97497693_97497949 0.13 KLHL32
 kelch-like family member 32
 14683
 0.28
chr6_126154204_126154432 0.13 NCOA7-AS1
 NCOA7 antisense RNA 1
 14314
 0.18
chr17_48530281_48530435 0.13 CHAD
 chondroadherin
 12428
 0.1
chr8_41853450_41853601 0.13 KAT6A
 K(lysine) acetyltransferase 6A
 37644
 0.15
chr7_17973312_17973463 0.13 SNX13
 sorting nexin 13
 6704
 0.28
chr22_40783696_40783896 0.13 RP5-1042K10.10
425
 0.81
chr1_88364293_88364444 0.13 ENSG00000199318
 .
 445312
 0.01
chr13_99566346_99566616 0.13 DOCK9
 dedicator of cytokinesis 9
 58243
 0.13
chr13_99723069_99723220 0.13 DOCK9
 dedicator of cytokinesis 9
 15516
 0.19
chr3_112692893_112693044 0.13 CD200R1
 CD200 receptor 1
 791
 0.59
chr17_58472537_58472688 0.13 C17orf64
 chromosome 17 open reading frame 64
 2822
 0.26
chr12_82336263_82336414 0.13 PPFIA2
 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
 183006
 0.03
chr3_186729650_186729921 0.13 ST6GAL1
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
 9858
 0.24
chr15_85934213_85934364 0.13 ENSG00000251891
 .
 1173
 0.52
chr2_198007042_198007193 0.13 ANKRD44
 ankyrin repeat domain 44
 5511
 0.27
chr9_93570502_93570735 0.13 SYK
 spleen tyrosine kinase
 6409
 0.34
chr13_111225360_111225511 0.13 RAB20
 RAB20, member RAS oncogene family
 11355
 0.21
chr6_42006686_42006952 0.13 CCND3
 cyclin D3
 9605
 0.15
chr9_123956488_123956761 0.13 RAB14
 RAB14, member RAS oncogene family
 7523
 0.16
chr4_109453536_109453687 0.13 ENSG00000266046
 .
 44685
 0.17
chr2_43373091_43373242 0.13 ENSG00000207087
 .
 54534
 0.14
chr8_30501926_30502077 0.13 ENSG00000254172
 .
 795
 0.6
chr12_71117144_71117295 0.12 PTPRR
 protein tyrosine phosphatase, receptor type, R
 31154
 0.22
chr8_41899359_41899510 0.12 ENSG00000238966
 .
 1659
 0.39
chr10_35661911_35662062 0.12 CCNY
 cyclin Y
 36184
 0.16
chr14_68749923_68750260 0.12 ENSG00000243546
 .
 46835
 0.17
chr1_175166360_175166539 0.12 KIAA0040
 KIAA0040
 4370
 0.31
chr18_25757142_25757385 0.12 CDH2
 cadherin 2, type 1, N-cadherin (neuronal)
 147
 0.98
chr2_207854350_207854673 0.12 CPO
 carboxypeptidase O
 50233
 0.15
chr18_73122194_73122345 0.12 RP11-321M21.3
 HCG1996301; Uncharacterized protein
 3302
 0.31
chr7_27252518_27252718 0.12 HOTTIP
 HOXA distal transcript antisense RNA
 12562
 0.07
chr22_42232265_42232534 0.12 RP5-821D11.7
1730
 0.24
chr4_166178779_166178930 0.12 ENSG00000200974
 .
 5122
 0.22
chr10_8225843_8226238 0.12 GATA3
 GATA binding protein 3
 129271
 0.06
chr15_40410256_40410479 0.12 BMF
 Bcl2 modifying factor
 9274
 0.16
chr18_8787123_8787274 0.12 SOGA2
 SOGA family member 2
 2474
 0.3
chr1_111328214_111328365 0.12 ENSG00000199710
 .
 21161
 0.2
chr3_56729846_56730094 0.12 FAM208A
 family with sequence similarity 208, member A
 12705
 0.27
chr2_241503394_241503545 0.12 RNPEPL1
 arginyl aminopeptidase (aminopeptidase B)-like 1
 1752
 0.22
chr2_201752130_201752281 0.12 PPIL3
 peptidylprolyl isomerase (cyclophilin)-like 3
 1097
 0.27

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of CDX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1 0.2 GO:0001865 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.1 0.4 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.3 GO:0031062 positive regulation of histone methylation(GO:0031062)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.2 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.1 GO:0046137 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.2 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.2 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0 0.1 GO:0032060 bleb assembly(GO:0032060)
0.0 0.1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.1 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.1 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.1 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:0021780 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.1 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.1 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.1 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:0032641 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0 0.0 GO:1903429 regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0 0.0 GO:0002085 inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0 0.0 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0002335 mature B cell differentiation(GO:0002335)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 0.1 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.1 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.1 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.0 GO:0033622 integrin activation(GO:0033622)
0.0 0.1 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.3 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:0043276 anoikis(GO:0043276)
0.0 0.1 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.0 GO:0070254 mucus secretion(GO:0070254)
0.0 0.1 GO:0048548 regulation of pinocytosis(GO:0048548)
0.0 0.0 GO:0010587 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0 0.0 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.0 GO:0060789 hair follicle placode formation(GO:0060789)
0.0 0.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 0.0 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0051294 establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0 0.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.0 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.0 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.1 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0044380 protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.3 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.1 GO:0001773 myeloid dendritic cell activation(GO:0001773)
0.0 0.2 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.0 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.0 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.1 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.1 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.1 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.2 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 0.0 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.0 0.1 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.0 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.1 GO:0048488 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.0 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.0 0.0 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.0 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.0 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.1 GO:1901663 quinone biosynthetic process(GO:1901663)
0.0 0.0 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.0 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0046348 amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0 0.0 GO:0015825 L-serine transport(GO:0015825)
0.0 0.0 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.0 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.1 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.1 GO:0008653 lipopolysaccharide metabolic process(GO:0008653)
0.0 0.0 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.0 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.2 GO:0007032 endosome organization(GO:0007032)
0.0 0.1 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.0 GO:1901661 quinone metabolic process(GO:1901661)
0.0 0.0 GO:0003351 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.2 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.2 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.1 GO:0060487 lung cell differentiation(GO:0060479) lung epithelial cell differentiation(GO:0060487)
0.0 0.0 GO:2001280 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.0 GO:0032069 regulation of nuclease activity(GO:0032069)
0.0 0.2 GO:0048536 spleen development(GO:0048536)
0.0 0.0 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.1 GO:0070076 histone lysine demethylation(GO:0070076)
0.0 0.1 GO:0085020 protein K6-linked ubiquitination(GO:0085020)
0.0 0.0 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.0 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0050854 regulation of antigen receptor-mediated signaling pathway(GO:0050854)
0.0 0.0 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320)
0.0 0.0 GO:0070669 response to interleukin-2(GO:0070669)
0.0 0.1 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.0 GO:0046643 regulation of gamma-delta T cell activation(GO:0046643) positive regulation of gamma-delta T cell activation(GO:0046645)
0.0 0.1 GO:0006067 ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.2 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.1 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.0 GO:0032009 early phagosome(GO:0032009)
0.0 0.1 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.0 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.1 GO:0042598 obsolete vesicular fraction(GO:0042598)
0.0 0.0 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.0 GO:0042583 chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0 0.1 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.0 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.0 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.0 GO:0016589 NURF complex(GO:0016589)
0.0 0.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.0 GO:0030312 external encapsulating structure(GO:0030312)
0.0 0.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.1 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.2 GO:0019959 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.2 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.2 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.3 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.1 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.0 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.0 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.2 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.3 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.0 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.0 0.0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.1 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.0 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0016421 CoA carboxylase activity(GO:0016421)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.0 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.0 GO:0035197 siRNA binding(GO:0035197)
0.0 0.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.0 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.0 GO:0004516 nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0 0.0 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.1 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.0 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.0 GO:0043495 protein anchor(GO:0043495)
0.0 0.0 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.0 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.0 GO:0034190 apolipoprotein receptor binding(GO:0034190)
0.0 0.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.0 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.1 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.0 GO:0032558 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.1 GO:0016595 glutamate binding(GO:0016595)
0.0 0.0 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.0 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.1 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.0 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.1 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.2 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.3 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.0 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.1 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.0 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.3 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.4 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.0 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.3 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.1 PID EPO PATHWAY EPO signaling pathway
0.0 0.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.6 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.0 REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.0 0.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.3 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.1 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.0 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.0 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.1 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.2 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.0 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.1 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.0 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.0 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 0.1 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.0 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.0 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.3 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development