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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for CPEB1

Z-value: 1.30

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Transcription factors associated with CPEB1

Gene Symbol	Gene ID	Gene Info
CPEB1 Ensembl NCBI GeneCards UniProt	ENSG00000214575.5	CPEB1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
CPEB1	chr15_83315771_83316117	70	0.898115	0.90	1.0e-03	Click!
CPEB1	chr15_83239391_83239542	1043	0.414979	-0.61	8.0e-02	Click!
CPEB1	chr15_83240171_83240322	263	0.876035	-0.53	1.4e-01	Click!
CPEB1	chr15_83235277_83235428	5157	0.136551	-0.50	1.7e-01	Click!
CPEB1	chr15_83241226_83241377	473	0.732689	-0.44	2.3e-01	Click!

Activity of the CPEB1 motif across conditions

Conditions sorted by the z-value of the CPEB1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_99721349_99721548	0.31	AL109767.1		7837	0.22
chr17_37948646_37948906	0.29	IKZF3	IKAROS family zinc finger 3 (Aiolos)	14298	0.14
chr17_47896409_47896901	0.28	RP11-304F15.3		26617	0.12
chr10_22962552_22962703	0.28	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	40410	0.2
chr10_43843752_43843981	0.27	ENSG00000221468	.	6632	0.19
chr2_143888983_143889411	0.25	ARHGAP15	Rho GTPase activating protein 15	2314	0.39
chr20_56195788_56195967	0.24	ZBP1	Z-DNA binding protein 1	245	0.94
chr8_2166897_2167149	0.24	MYOM2	myomesin 2	173839	0.03
chr18_43808452_43808604	0.23	C18orf25	chromosome 18 open reading frame 25	54528	0.13
chr9_115066997_115067151	0.23	PTBP3	polypyrimidine tract binding protein 3	28049	0.14
chr17_33859475_33859650	0.23	SLFN12L	schlafen family member 12-like	5318	0.12
chr14_92435696_92435980	0.23	FBLN5	fibulin 5	21507	0.18
chr17_37934637_37934793	0.23	IKZF3	IKAROS family zinc finger 3 (Aiolos)	237	0.9
chr3_114749732_114749883	0.23	ZBTB20	zinc finger and BTB domain containing 20	40415	0.23
chr3_18597997_18598194	0.23	ENSG00000228956	.	29431	0.24
chr3_197595834_197596031	0.23	LRCH3	leucine-rich repeats and calponin homology (CH) domain containing 3	2846	0.23
chr10_32749220_32749452	0.22	CCDC7	coiled-coil domain containing 7	8787	0.22
chr1_59144710_59144861	0.22	MYSM1	Myb-like, SWIRM and MPN domains 1	20979	0.2
chrX_78517963_78518114	0.22	GPR174	G protein-coupled receptor 174	91569	0.09
chr22_20919404_20919765	0.22	MED15	mediator complex subunit 15	14007	0.14
chr9_95733021_95733387	0.21	FGD3	FYVE, RhoGEF and PH domain containing 3	3560	0.27
chr14_35400951_35401102	0.21	ENSG00000199980	.	1723	0.34
chr11_108108099_108108300	0.21	ENSG00000206967	.	7868	0.16
chrX_53712364_53712515	0.21	HUWE1	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1234	0.59
chr3_151957728_151957952	0.21	MBNL1	muscleblind-like splicing regulator 1	27989	0.2
chr1_193428730_193429035	0.21	ENSG00000252241	.	272192	0.01
chr22_29195216_29195505	0.20	XBP1	X-box binding protein 1	761	0.48
chr6_89626872_89627052	0.20	RNGTT	RNA guanylyltransferase and 5'-phosphatase	46318	0.15
chr17_62140117_62140268	0.20	ICAM2	intercellular adhesion molecule 2	42198	0.11
chr14_99720519_99720759	0.20	AL109767.1		8646	0.22
chr2_12849849_12850137	0.20	TRIB2	tribbles pseudokinase 2	7022	0.27
chr2_238978929_238979080	0.20	SCLY	selenocysteine lyase	899	0.56
chr11_60767130_60767281	0.20	CD6	CD6 molecule	8801	0.13
chr2_202059112_202059539	0.19	CASP10	caspase 10, apoptosis-related cysteine peptidase	11407	0.15
chr6_36077167_36077664	0.19	MAPK13	mitogen-activated protein kinase 13	20683	0.16
chr11_5246485_5246763	0.19	ENSG00000221031	.	755	0.38
chr1_62188467_62188709	0.19	TM2D1	TM2 domain containing 1	2217	0.35
chr5_178978355_178978506	0.19	RUFY1	RUN and FYVE domain containing 1	591	0.74
chr16_9048805_9048966	0.19	USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	1352	0.47
chr4_40189463_40189614	0.18	RHOH	ras homolog family member H	3135	0.27
chr2_24272218_24272506	0.18	C2orf44	chromosome 2 open reading frame 44	83	0.67
chr14_99691163_99691558	0.18	AL109767.1		37925	0.16
chr2_106545238_106545692	0.18	AC009505.2		71832	0.11
chr14_99726600_99726784	0.18	AL109767.1		2593	0.31
chr2_177080_177288	0.17	AC079779.7		20385	0.21
chr1_203259066_203259291	0.17	BTG2	BTG family, member 2	15486	0.16
chr12_96755738_96755889	0.17	CDK17	cyclin-dependent kinase 17	26805	0.18
chr17_8147401_8147552	0.17	PFAS	phosphoribosylformylglycinamidine synthase	3460	0.11
chr1_101395582_101395733	0.17	SLC30A7	solute carrier family 30 (zinc transporter), member 7	31727	0.12
chr12_66684119_66684270	0.17	ENSG00000222744	.	2269	0.26
chr4_143635559_143635710	0.17	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	131809	0.06
chr14_61817217_61817623	0.17	PRKCH	protein kinase C, eta	2811	0.3
chr14_21697616_21697899	0.17	HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	1824	0.32
chr17_46670095_46670275	0.17	HOXB-AS3	HOXB cluster antisense RNA 3	503	0.48
chr12_42722388_42722539	0.16	PPHLN1	periphilin 1	2483	0.22
chr18_60970002_60970404	0.16	RP11-28F1.2		11112	0.18
chr3_60090466_60090753	0.16	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	133026	0.06
chr8_66769940_66770103	0.16	PDE7A	phosphodiesterase 7A	15834	0.27
chr7_8173692_8173968	0.16	AC006042.6		20175	0.19
chr18_67626079_67626351	0.16	CD226	CD226 molecule	1803	0.48
chr20_57734207_57734542	0.16	ZNF831	zinc finger protein 831	31701	0.19
chr3_133210635_133210930	0.16	BFSP2-AS1	BFSP2 antisense RNA 1	36162	0.16
chr5_56031061_56031244	0.16	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	80249	0.09
chr18_3259945_3260096	0.16	RP13-270P17.1		1800	0.26
chr17_37925720_37925871	0.16	IKZF3	IKAROS family zinc finger 3 (Aiolos)	8683	0.13
chr3_33843113_33843264	0.16	PDCD6IP	programmed cell death 6 interacting protein	3073	0.38
chr7_12252889_12253205	0.16	TMEM106B	transmembrane protein 106B	2098	0.48
chr15_26078408_26078559	0.16	ENSG00000199214	.	15353	0.17
chr17_48965132_48965283	0.16	TOB1	transducer of ERBB2, 1	19868	0.15
chr14_99665484_99665650	0.16	AL162151.4		40814	0.17
chr2_204596528_204596679	0.16	CD28	CD28 molecule	25187	0.19
chr7_135347931_135348131	0.16	C7orf73	chromosome 7 open reading frame 73	762	0.59
chr16_67097233_67097384	0.16	CBFB	core-binding factor, beta subunit	33453	0.09
chr1_101396601_101396752	0.16	SLC30A7	solute carrier family 30 (zinc transporter), member 7	30708	0.13
chr2_38056365_38056516	0.16	CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	90829	0.08
chr12_25536580_25536731	0.16	ENSG00000201439	.	20707	0.24
chr17_26206098_26206388	0.16	LYRM9	LYR motif containing 9	4080	0.19
chr5_54391771_54392054	0.16	GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	6564	0.16
chr3_33038134_33038326	0.16	CCR4	chemokine (C-C motif) receptor 4	45164	0.15
chr16_12006362_12006679	0.16	GSPT1	G1 to S phase transition 1	2540	0.15
chr14_98637494_98637668	0.16	ENSG00000222066	.	160506	0.04
chr6_112006099_112006376	0.16	FYN	FYN oncogene related to SRC, FGR, YES	35028	0.16
chr5_55391166_55391317	0.16	ANKRD55	ankyrin repeat domain 55	21537	0.16
chr5_148733548_148733699	0.16	GRPEL2-AS1	GRPEL2 atnisense RNA 1	3582	0.14
chr3_46411260_46411477	0.16	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	265	0.9
chr1_8212069_8212240	0.15	ENSG00000200975	.	54503	0.13
chr13_40763533_40763684	0.15	ENSG00000207458	.	37356	0.23
chr17_71208357_71208949	0.15	COG1	component of oligomeric golgi complex 1	6355	0.15
chr2_204812325_204812548	0.15	ICOS	inducible T-cell co-stimulator	10933	0.28
chr6_111495332_111495527	0.15	SLC16A10	solute carrier family 16 (aromatic amino acid transporter), member 10	1531	0.44
chr12_9807704_9808028	0.15	RP11-705C15.2		1587	0.25
chr10_120458675_120458868	0.15	CACUL1	CDK2-associated, cullin domain 1	55987	0.12
chr4_143621409_143621560	0.15	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	139662	0.05
chr13_100194616_100194885	0.15	ENSG00000212197	.	6100	0.2
chr2_152144415_152144634	0.15	NMI	N-myc (and STAT) interactor	1884	0.36
chr6_151735099_151735250	0.15	ZBTB2	zinc finger and BTB domain containing 2	22491	0.13
chr22_22117730_22117960	0.15	YPEL1	yippee-like 1 (Drosophila)	27722	0.11
chr2_44796225_44796376	0.15	CAMKMT	calmodulin-lysine N-methyltransferase	196419	0.03
chr12_22484745_22484973	0.15	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	2238	0.44
chr14_38546372_38546618	0.15	CTD-2058B24.2		13868	0.25
chr7_130596773_130597211	0.15	ENSG00000226380	.	34694	0.19
chr6_139485972_139486167	0.15	HECA	headcase homolog (Drosophila)	29820	0.2
chr2_10815541_10815692	0.15	NOL10	nucleolar protein 10	3800	0.22
chr6_502144_502346	0.15	RP1-20B11.2		21926	0.26
chr2_158746528_158746679	0.15	UPP2	uridine phosphorylase 2	13389	0.16
chr2_95741879_95742163	0.15	AC103563.9		23100	0.15
chr1_167458272_167458474	0.15	CD247	CD247 molecule	29402	0.16
chr22_40296066_40296492	0.15	GRAP2	GRB2-related adaptor protein 2	807	0.6
chrX_12972541_12972692	0.15	TMSB4X	thymosin beta 4, X-linked	20611	0.19
chr12_45269447_45269715	0.15	NELL2	NEL-like 2 (chicken)	14	0.98
chr4_82414160_82414311	0.15	RASGEF1B	RasGEF domain family, member 1B	21166	0.28
chr2_102186414_102186691	0.15	RFX8	RFX family member 8, lacking RFX DNA binding domain	95387	0.08
chr14_98665522_98665718	0.15	ENSG00000222066	.	132467	0.05
chr8_126940986_126941137	0.15	ENSG00000206695	.	27866	0.26
chrX_70763186_70763395	0.15	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase	6426	0.2
chr3_56912022_56912345	0.15	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	38316	0.18
chr11_133798697_133798899	0.15	IGSF9B	immunoglobulin superfamily, member 9B	17389	0.18
chr10_11252064_11252436	0.15	RP3-323N1.2		38911	0.17
chr6_143862532_143862683	0.15	PHACTR2	phosphatase and actin regulator 2	4625	0.18
chr17_33171161_33171312	0.15	CCT6B	chaperonin containing TCP1, subunit 6B (zeta 2)	117185	0.05
chr5_172425652_172425803	0.15	ATP6V0E1	ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1	14893	0.14
chr2_7052046_7052272	0.14	RNF144A	ring finger protein 144A	5364	0.19
chr1_77774898_77775049	0.14	AK5	adenylate kinase 5	26209	0.18
chr1_111326257_111326605	0.14	ENSG00000199710	.	19303	0.2
chr11_117916276_117916450	0.14	ENSG00000272075	.	21589	0.14
chr1_184813678_184813906	0.14	ENSG00000252222	.	23169	0.2
chr11_35351604_35352020	0.14	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	28737	0.17
chr5_156953479_156953635	0.14	ADAM19	ADAM metallopeptidase domain 19	23727	0.15
chr5_39190224_39190381	0.14	FYB	FYN binding protein	12827	0.27
chr11_108084515_108084666	0.14	ATM	ataxia telangiectasia mutated	8621	0.16
chr3_151929579_151929730	0.14	MBNL1	muscleblind-like splicing regulator 1	56175	0.14
chr21_16893074_16893225	0.14	ENSG00000212564	.	93453	0.09
chr14_22621058_22621209	0.14	ENSG00000238634	.	10246	0.28
chr3_101832900_101833053	0.14	ZPLD1	zona pellucida-like domain containing 1	14888	0.29
chr13_42041149_42041395	0.14	RGCC	regulator of cell cycle	9577	0.16
chr1_121311422_121311588	0.14	FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)	375568	0.01
chr6_110882269_110882528	0.14	CDK19	cyclin-dependent kinase 19	82123	0.08
chr14_64329252_64329512	0.14	SYNE2	spectrin repeat containing, nuclear envelope 2	9650	0.22
chr3_195250896_195251062	0.14	ENSG00000252620	.	960	0.52
chr4_40236655_40236806	0.14	RHOH	ras homolog family member H	34766	0.17
chr1_93420237_93420388	0.14	FAM69A	family with sequence similarity 69, member A	6745	0.13
chr16_53530038_53530189	0.14	AKTIP	AKT interacting protein	4128	0.23
chr1_43500743_43500945	0.14	ENSG00000252803	.	11536	0.19
chr4_148972762_148973133	0.14	RP11-76G10.1		94675	0.09
chr5_14704726_14704885	0.14	FAM105B	family with sequence similarity 105, member B	23146	0.19
chr6_35649971_35650157	0.14	FKBP5	FK506 binding protein 5	6628	0.14
chr3_16356399_16356550	0.14	RP11-415F23.2		528	0.76
chr2_205836626_205836826	0.14	PARD3B	par-3 family cell polarity regulator beta	426003	0.01
chr17_37946299_37946450	0.14	IKZF3	IKAROS family zinc finger 3 (Aiolos)	11896	0.14
chr14_21136496_21136717	0.14	ENSG00000199461	.	10964	0.09
chr22_40730411_40730669	0.14	ADSL	adenylosuccinate lyase	11967	0.19
chr10_124175104_124175255	0.14	ENSG00000265442	.	1302	0.43
chr6_130505643_130505870	0.14	SAMD3	sterile alpha motif domain containing 3	29758	0.2
chr15_57857934_57858132	0.14	GCOM1	GRINL1A complex locus 1	26073	0.17
chr19_1057848_1057999	0.14	ABCA7	ATP-binding cassette, sub-family A (ABC1), member 7	990	0.32
chr14_102294369_102294541	0.14	CTD-2017C7.1		11413	0.15
chr3_15578936_15579113	0.14	COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	15766	0.14
chr7_129545877_129546028	0.14	UBE2H	ubiquitin-conjugating enzyme E2H	45215	0.1
chr13_27296341_27296492	0.14	GPR12	G protein-coupled receptor 12	38011	0.2
chr7_142504543_142504845	0.14	PRSS3P2	protease, serine, 3 pseudogene 2	23563	0.15
chr18_13297039_13297305	0.14	LDLRAD4	low density lipoprotein receptor class A domain containing 4	19070	0.18
chr1_153234965_153235116	0.14	LOR	loricrin	2864	0.19
chr6_110515654_110515805	0.14	CDC40	cell division cycle 40	14105	0.22
chr6_36932436_36932655	0.14	PI16	peptidase inhibitor 16	10336	0.17
chr4_143621654_143621881	0.14	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	139945	0.05
chr14_90105259_90105410	0.14	RP11-944C7.1	Protein LOC100506792	7424	0.15
chr12_45608916_45609133	0.14	ANO6	anoctamin 6	779	0.77
chr6_26358903_26359054	0.14	ENSG00000252399	.	5714	0.1
chr6_139492633_139492784	0.14	HECA	headcase homolog (Drosophila)	36459	0.17
chr14_106630342_106630519	0.14	IGHV1-17	immunoglobulin heavy variable 1-17 (pseudogene)	1019	0.19
chr17_46508666_46508817	0.14	SKAP1	src kinase associated phosphoprotein 1	1160	0.41
chr16_28998091_28998242	0.14	LAT	linker for activation of T cells	633	0.49
chr1_24839011_24839397	0.14	RCAN3	RCAN family member 3	1606	0.35
chr6_108109631_108109782	0.14	SCML4	sex comb on midleg-like 4 (Drosophila)	16251	0.26
chr16_67538677_67538891	0.14	FAM65A	family with sequence similarity 65, member A	13537	0.09
chr10_63809503_63809654	0.14	ARID5B	AT rich interactive domain 5B (MRF1-like)	608	0.82
chr10_90590706_90591168	0.14	ANKRD22	ankyrin repeat domain 22	20638	0.15
chr15_40743963_40744180	0.14	RP11-64K12.9		2767	0.14
chr10_14605059_14605230	0.14	FAM107B	family with sequence similarity 107, member B	6965	0.26
chr1_90077786_90078098	0.14	RP11-413E1.4		17342	0.16
chr5_80849712_80849863	0.14	SSBP2	single-stranded DNA binding protein 2	40251	0.21
chr4_110496140_110496528	0.13	CCDC109B	coiled-coil domain containing 109B	14188	0.22
chr10_6635069_6635386	0.13	PRKCQ	protein kinase C, theta	12964	0.3
chr2_95690474_95690625	0.13	MAL	mal, T-cell differentiation protein	880	0.49
chr15_75725504_75725655	0.13	SIN3A	SIN3 transcription regulator family member A	18347	0.15
chr8_101728028_101728286	0.13	PABPC1	poly(A) binding protein, cytoplasmic 1	1961	0.25
chr8_29389067_29389218	0.13	RP4-676L2.1		178455	0.03
chr17_76710387_76710538	0.13	CYTH1	cytohesin 1	2645	0.28
chr10_52380207_52380358	0.13	SGMS1	sphingomyelin synthase 1	3461	0.21
chr19_11085110_11085263	0.13	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	9642	0.13
chr1_7811961_7812165	0.13	CAMTA1	calmodulin binding transcription activator 1	7042	0.17
chr21_43827327_43827478	0.13	UBASH3A	ubiquitin associated and SH3 domain containing A	3376	0.17
chr20_52216616_52216767	0.13	ZNF217	zinc finger protein 217	6313	0.21
chr2_12641093_12641393	0.13	ENSG00000207183	.	89616	0.1
chr14_98606379_98606534	0.13	C14orf64	chromosome 14 open reading frame 64	161995	0.04
chr9_74375544_74375695	0.13	TMEM2	transmembrane protein 2	7683	0.3
chr5_54399188_54399417	0.13	GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	826	0.55
chr5_118574777_118574928	0.13	ENSG00000266587	.	18280	0.18
chr5_49931517_49931668	0.13	PARP8	poly (ADP-ribose) polymerase family, member 8	30141	0.26
chr1_100856626_100856777	0.13	ENSG00000216067	.	12370	0.2

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of CPEB1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.3	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.2	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.1	0.2	GO:1900121	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.1	0.2	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.2	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.1	GO:1903312	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.1	0.4	GO:0006491	N-glycan processing(GO:0006491)
0.1	0.2	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.4	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.2	GO:0032875	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.1	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.2	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.1	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.3	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.2	GO:0009151	purine deoxyribonucleotide metabolic process(GO:0009151)
0.0	0.2	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0002363	alpha-beta T cell lineage commitment(GO:0002363)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.4	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.1	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0002329	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.1	GO:0048867	stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0	0.2	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.0	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0	0.1	GO:0071922	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.0	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.3	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0007097	nuclear migration(GO:0007097)
0.0	0.3	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0031442	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.2	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.0	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.1	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	1.6	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.2	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0002837	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0	0.1	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065) UDP-glucuronate metabolic process(GO:0046398)
0.0	0.0	GO:0070601	centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0	0.1	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.1	GO:0071168	protein localization to chromatin(GO:0071168)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0040001	establishment of mitotic spindle localization(GO:0040001)
0.0	0.1	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:0071801	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.1	GO:0007063	regulation of sister chromatid cohesion(GO:0007063)
0.0	0.1	GO:0019720	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.0	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.2	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.3	GO:0006513	protein monoubiquitination(GO:0006513)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0046606	negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0	0.1	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.1	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.0	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.0	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0032119	sequestering of zinc ion(GO:0032119)
0.0	0.0	GO:0033622	integrin activation(GO:0033622)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.0	GO:1904358	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.0	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.0	GO:0033083	regulation of immature T cell proliferation(GO:0033083) regulation of immature T cell proliferation in thymus(GO:0033084)
0.0	0.0	GO:0034382	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0	0.1	GO:0051322	anaphase(GO:0051322)
0.0	0.1	GO:0090004	positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.0	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.0	GO:0010626	regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.0	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.1	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.1	GO:0032784	regulation of DNA-templated transcription, elongation(GO:0032784)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.0	GO:0051708	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.0	0.0	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.0	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.0	0.0	GO:0051136	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.0	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.1	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.1	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.0	GO:0022009	establishment of endothelial blood-brain barrier(GO:0014045) central nervous system vasculogenesis(GO:0022009)
0.0	0.1	GO:0006337	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.1	GO:0008655	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.0	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.0	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.0	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.2	GO:0006085	acetyl-CoA biosynthetic process(GO:0006085)
0.0	0.2	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.0	0.1	GO:0031297	replication fork processing(GO:0031297)
0.0	0.0	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.0	GO:0002707	negative regulation of lymphocyte mediated immunity(GO:0002707)
0.0	0.1	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.0	GO:0002862	negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0	0.0	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.0	GO:0032203	telomere formation via telomerase(GO:0032203)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0019228	neuronal action potential(GO:0019228)
0.0	0.0	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.0	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.0	GO:0070266	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.0	GO:0002704	negative regulation of leukocyte mediated immunity(GO:0002704)
0.0	0.0	GO:0034287	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.1	GO:0035305	negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0	0.0	GO:0034776	response to histamine(GO:0034776)
0.0	0.1	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.0	0.1	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.0	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.0	0.0	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.1	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.0	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.0	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.0	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.2	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	0.0	GO:0070244	negative regulation of thymocyte apoptotic process(GO:0070244)
0.0	0.0	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0009713	catechol-containing compound biosynthetic process(GO:0009713) catecholamine biosynthetic process(GO:0042423)
0.0	0.1	GO:0006349	regulation of gene expression by genetic imprinting(GO:0006349)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.0	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0	0.1	GO:0032461	positive regulation of protein oligomerization(GO:0032461)
0.0	0.0	GO:0051299	centrosome separation(GO:0051299)
0.0	0.0	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.1	GO:0015904	tetracycline transport(GO:0015904)
0.0	0.0	GO:0007549	dosage compensation(GO:0007549)
0.0	0.0	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.0	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.0	GO:0017085	response to insecticide(GO:0017085)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.2	GO:0060334	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0032097	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.1	0.2	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.5	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.2	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.2	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.3	GO:0045120	pronucleus(GO:0045120)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0000124	SAGA complex(GO:0000124)
0.0	0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.2	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0	0.4	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.2	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	0.5	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.0	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.3	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.1	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.2	GO:0008023	transcription elongation factor complex(GO:0008023)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:1902555	endoribonuclease complex(GO:1902555)
0.0	0.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.1	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.2	GO:0005844	polysome(GO:0005844)
0.0	0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0016585	obsolete chromatin remodeling complex(GO:0016585)
0.0	0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0008278	cohesin complex(GO:0008278)
0.0	0.0	GO:0016589	NURF complex(GO:0016589)
0.0	0.2	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.0	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.0	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.2	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.1	GO:0045239	tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.3	GO:0000152	nuclear ubiquitin ligase complex(GO:0000152) anaphase-promoting complex(GO:0005680)
0.0	0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.1	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.0	0.0	GO:0046540	U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0	0.1	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.2	GO:0005892	acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1	0.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.2	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.2	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.3	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.3	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.0	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.2	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.1	GO:0008061	chitin binding(GO:0008061)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.2	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.1	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.7	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.2	GO:0019206	nucleoside kinase activity(GO:0019206)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.0	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.2	GO:0004576	oligosaccharyl transferase activity(GO:0004576)
0.0	0.1	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.2	GO:0030276	clathrin binding(GO:0030276)
0.0	0.4	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.2	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.1	GO:0004308	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	0.1	GO:0008079	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.1	GO:0004437	obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437)
0.0	0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.5	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.0	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.0	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.0	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.0	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0016944	obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.0	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.1	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0016840	carbon-nitrogen lyase activity(GO:0016840)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.0	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.6	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.0	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.0	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.0	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.0	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.3	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.0	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.0	GO:0032552	deoxyribonucleotide binding(GO:0032552)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.2	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.1	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.0	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.2	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.0	GO:0042166	acetylcholine binding(GO:0042166)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.4	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
1.1	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.2	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.2	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.7	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.2	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.3	PID REELIN PATHWAY	Reelin signaling pathway
0.2	PID ALK2 PATHWAY	ALK2 signaling events
0.4	PID TNF PATHWAY	TNF receptor signaling pathway
0.3	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.3	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.1	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.5	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	PID FAS PATHWAY	FAS (CD95) signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	1.6	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.3	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.4	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.0	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0	0.1	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.2	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.3	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.0	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.3	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.2	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.0	0.1	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.2	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.2	REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	Genes involved in Activation of Chaperones by ATF6-alpha
0.0	0.2	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.2	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.2	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.2	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.1	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.3	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.0	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	0.2	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.0	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.1	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.0	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.0	0.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.3	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.0	0.2	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle