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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for CREB3L2

Z-value: 1.06

Motif logo

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Transcription factors associated with CREB3L2

Gene Symbol Gene ID Gene Info
CREB3L2
ENSG00000182158.10 cAMP responsive element binding protein 3 like 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr7_137668727_137668878CREB3L2179910.1833520.781.3e-02Click!
chr7_137663575_137663726CREB3L2231430.1720340.771.5e-02Click!
chr7_137573299_137573450CREB3L2396410.1534790.771.6e-02Click!
chr7_137605978_137606391CREB3L268310.230519-0.771.6e-02Click!
chr7_137621255_137621573CREB3L227780.2923250.742.2e-02Click!

Activity of the CREB3L2 motif across conditions

Conditions sorted by the z-value of the CREB3L2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr6_16681395_16681795 0.77 RP1-151F17.1
79774
 0.1
chr17_48718114_48718630 0.54 ABCC3
 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
 6154
 0.13
chr14_100906069_100906661 0.52 RP11-362L22.1
33123
 0.1
chr15_68683192_68683351 0.49 ITGA11
 integrin, alpha 11
 41221
 0.18
chr6_147235336_147235538 0.49 STXBP5-AS1
 STXBP5 antisense RNA 1
 1584
 0.55
chr16_29167036_29167187 0.49 CTB-134H23.3
48345
 0.11
chr8_126187977_126188128 0.49 NSMCE2
 non-SMC element 2, MMS21 homolog (S. cerevisiae)
 51666
 0.14
chr4_129308818_129308969 0.46 PGRMC2
 progesterone receptor membrane component 2
 98909
 0.09
chr9_137394449_137394849 0.44 RXRA
 retinoid X receptor, alpha
 96221
 0.07
chr18_53398894_53399045 0.44 TCF4
 transcription factor 4
 66951
 0.14
chr2_223574012_223574225 0.44 ENSG00000238852
 .
 11399
 0.21
chr14_91281521_91281794 0.44 TTC7B
 tetratricopeptide repeat domain 7B
 1104
 0.63
chr1_209831123_209831274 0.43 LAMB3
 laminin, beta 3
 5387
 0.15
chr5_118733387_118734036 0.42 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 41981
 0.13
chr10_1290240_1290555 0.42 ADARB2
 adenosine deaminase, RNA-specific, B2 (non-functional)
 44072
 0.17
chr5_71475626_71475777 0.42 MAP1B
 microtubule-associated protein 1B
 246
 0.94
chr21_35709927_35710173 0.41 KCNE2
 potassium voltage-gated channel, Isk-related family, member 2
 26273
 0.13
chr7_141615794_141616062 0.40 OR9A4
 olfactory receptor, family 9, subfamily A, member 4
 2689
 0.16
chr2_71682494_71682648 0.40 DYSF
 dysferlin
 1719
 0.44
chr4_120986498_120987561 0.39 RP11-679C8.2
1084
 0.42
chr22_42765026_42765177 0.38 TCF20
 transcription factor 20 (AR1)
 25479
 0.18
chr9_94660876_94661276 0.38 ROR2
 receptor tyrosine kinase-like orphan receptor 2
 50086
 0.18
chr21_30754344_30754495 0.38 ENSG00000239171
 .
 7391
 0.18
chr6_42283087_42283238 0.38 ENSG00000221252
 .
 96972
 0.06
chr10_79638365_79638516 0.38 AL391421.1
 Uncharacterized protein; cDNA FLJ43696 fis, clone TBAES2007964
 11807
 0.18
chr3_139020939_139021090 0.38 MRPS22
 mitochondrial ribosomal protein S22
 41847
 0.13
chr1_201237669_201237867 0.38 PKP1
 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
 14812
 0.18
chr1_145526041_145526192 0.37 ITGA10
 integrin, alpha 10
 1081
 0.31
chr1_8882630_8882823 0.37 RERE
 arginine-glutamic acid dipeptide (RE) repeats
 5024
 0.19
chr16_11295208_11295453 0.37 RMI2
 RecQ mediated genome instability 2
 48176
 0.08
chr15_77713627_77714545 0.37 HMG20A
 high mobility group 20A
 733
 0.64
chr5_134773694_134773956 0.36 C5orf20
 chromosome 5 open reading frame 20
 9213
 0.14
chr11_67896240_67896572 0.36 CTD-2655K5.1
859
 0.55
chr3_29376763_29376914 0.36 ENSG00000216169
 .
 34074
 0.18
chr18_22878825_22879093 0.36 CTD-2006O16.2
3131
 0.37
chr6_52379346_52379497 0.36 TRAM2
 translocation associated membrane protein 2
 62292
 0.12
chr15_35598915_35599148 0.36 ENSG00000265102
 .
 65534
 0.14
chr2_112763039_112763349 0.35 MERTK
 c-mer proto-oncogene tyrosine kinase
 13796
 0.22
chr20_25208276_25208481 0.35 AL035252.1
 HCG2018895; Uncharacterized protein
 1008
 0.49
chr1_33849901_33850220 0.35 PHC2
 polyhomeotic homolog 2 (Drosophila)
 8866
 0.16
chr1_59602387_59602647 0.35 FGGY
 FGGY carbohydrate kinase domain containing
 159793
 0.04
chr6_145569007_145569263 0.34 ENSG00000221796
 .
 100759
 0.09
chr10_134330476_134330668 0.34 LINC01165
 long intergenic non-protein coding RNA 1165
 5381
 0.22
chr1_41467777_41468071 0.34 CTPS1
 CTP synthase 1
 19091
 0.19
chr21_39660692_39660843 0.33 KCNJ15
 potassium inwardly-rectifying channel, subfamily J, member 15
 7712
 0.29
chr16_72405306_72405606 0.33 ENSG00000207514
 .
 5147
 0.31
chr12_48147567_48147718 0.33 SLC48A1
 solute carrier family 48 (heme transporter), member 1
 57
 0.96
chr16_55530572_55531230 0.33 MMP2
 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
 8327
 0.22
chr6_13397775_13398015 0.33 GFOD1
 glucose-fructose oxidoreductase domain containing 1
 10474
 0.21
chr14_61789232_61789447 0.33 PRKCH
 protein kinase C, eta
 43
 0.71
chr15_90325381_90325563 0.32 MESP2
 mesoderm posterior 2 homolog (mouse)
 5883
 0.14
chr6_82575347_82575498 0.32 ENSG00000206886
 .
 101681
 0.07
chr4_57945352_57945503 0.32 ENSG00000238541
 .
 27084
 0.14
chr18_56658261_56658433 0.32 ENSG00000251870
 .
 64819
 0.11
chr1_107480050_107480201 0.32 PRMT6
 protein arginine methyltransferase 6
 119142
 0.07
chr1_37920990_37921188 0.32 LINC01137
 long intergenic non-protein coding RNA 1137
 18923
 0.15
chr2_112375416_112375598 0.31 ENSG00000266063
 .
 153204
 0.04
chr12_124870235_124870636 0.31 NCOR2
 nuclear receptor corepressor 2
 2935
 0.37
chr10_115821373_115821605 0.31 ADRB1
 adrenoceptor beta 1
 17683
 0.2
chr1_33798502_33798653 0.31 ENSG00000266239
 .
 484
 0.7
chr10_79291591_79291742 0.31 ENSG00000199592
 .
 55141
 0.15
chr5_159698543_159698722 0.31 ENSG00000243654
 .
 20163
 0.16
chr16_85424724_85424875 0.31 RP11-680G10.1
 Uncharacterized protein
 33730
 0.18
chr3_122785668_122785819 0.31 PDIA5
 protein disulfide isomerase family A, member 5
 174
 0.96
chr9_124051158_124051423 0.31 GSN
 gelsolin
 2420
 0.21
chr10_102124571_102124984 0.31 SCD
 stearoyl-CoA desaturase (delta-9-desaturase)
 17896
 0.13
chr9_6973383_6973534 0.30 KDM4C
 lysine (K)-specific demethylase 4C
 40330
 0.2
chr11_69402239_69402390 0.30 CCND1
 cyclin D1
 53541
 0.14
chr7_47616572_47616723 0.30 TNS3
 tensin 3
 4582
 0.32
chr6_7921829_7921980 0.30 TXNDC5
 thioredoxin domain containing 5 (endoplasmic reticulum)
 10857
 0.3
chr1_234688974_234689202 0.30 ENSG00000212144
 .
 39933
 0.14
chr7_1595634_1595900 0.30 TMEM184A
 transmembrane protein 184A
 11
 0.97
chr20_5844973_5845124 0.30 ENSG00000202380
 .
 25653
 0.17
chr1_45793013_45793296 0.30 HPDL
 4-hydroxyphenylpyruvate dioxygenase-like
 609
 0.67
chr13_20764967_20765118 0.30 GJB2
 gap junction protein, beta 2, 26kDa
 1123
 0.49
chr17_75307827_75307996 0.29 SEPT9
 septin 9
 7686
 0.23
chr1_15105044_15105255 0.29 KAZN
 kazrin, periplakin interacting protein
 145477
 0.05
chr19_18959817_18960274 0.29 UPF1
 UPF1 regulator of nonsense transcripts homolog (yeast)
 17235
 0.11
chr2_151337576_151337727 0.29 RND3
 Rho family GTPase 3
 4245
 0.38
chr16_700261_700412 0.29 WDR90
 WD repeat domain 90
 919
 0.22
chr17_75346852_75347029 0.29 SEPT9
 septin 9
 22332
 0.16
chr1_27916174_27916325 0.29 AHDC1
 AT hook, DNA binding motif, containing 1
 13853
 0.15
chr9_127030805_127030956 0.29 RP11-121A14.3
5725
 0.18
chr4_69331756_69331907 0.29 TMPRSS11E
 transmembrane protease, serine 11E
 18664
 0.25
chr8_18696899_18697278 0.29 PSD3
 pleckstrin and Sec7 domain containing 3
 14796
 0.23
chr1_25040508_25040659 0.29 CLIC4
 chloride intracellular channel 4
 31265
 0.15
chr12_14413818_14414239 0.29 ENSG00000251908
 .
 10753
 0.22
chr21_40144936_40145370 0.29 ETS2
 v-ets avian erythroblastosis virus E26 oncogene homolog 2
 32078
 0.22
chr20_30195413_30195568 0.29 ENSG00000264395
 .
 501
 0.67
chr22_37958323_37958474 0.29 CDC42EP1
 CDC42 effector protein (Rho GTPase binding) 1
 1263
 0.33
chr11_57282126_57282281 0.28 SLC43A1
 solute carrier family 43 (amino acid system L transporter), member 1
 115
 0.93
chr5_114795818_114795969 0.28 FEM1C
 fem-1 homolog c (C. elegans)
 84698
 0.08
chr13_98953540_98953691 0.28 FARP1
 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
 30397
 0.16
chr16_3900112_3900331 0.28 CREBBP
 CREB binding protein
 29900
 0.18
chr9_91390340_91390723 0.28 ENSG00000265873
 .
 29711
 0.24
chr10_77471952_77472136 0.28 RP11-367B6.2
30454
 0.19
chr1_9127158_9127594 0.28 SLC2A5
 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
 2228
 0.26
chr8_23396820_23397037 0.28 SLC25A37
 solute carrier family 25 (mitochondrial iron transporter), member 37
 10355
 0.16
chr17_35534355_35534506 0.28 ACACA
 acetyl-CoA carboxylase alpha
 10804
 0.24
chr5_14153391_14153542 0.28 TRIO
 trio Rho guanine nucleotide exchange factor
 9637
 0.32
chr16_57411779_57412024 0.28 CX3CL1
 chemokine (C-X3-C motif) ligand 1
 1017
 0.45
chr7_101688884_101689543 0.28 CTA-357J21.1
12910
 0.24
chr9_138818669_138818820 0.28 RP11-432J22.2
19086
 0.17
chr19_35939108_35939372 0.28 FFAR2
 free fatty acid receptor 2
 37
 0.96
chr6_83075536_83075687 0.27 TPBG
 trophoblast glycoprotein
 1650
 0.53
chr1_62070273_62070424 0.27 ENSG00000264551
 .
 24355
 0.25
chrX_52964621_52965041 0.27 FAM156A
 family with sequence similarity 156, member A
 20698
 0.18
chr9_109622867_109623098 0.27 ZNF462
 zinc finger protein 462
 2396
 0.34
chr18_59658543_59658754 0.27 RNF152
 ring finger protein 152
 97184
 0.08
chr17_76127130_76127305 0.27 TMC8
 transmembrane channel-like 8
 348
 0.54
chr10_81160624_81160775 0.27 RP11-342M3.5
18615
 0.19
chr13_50772718_50772869 0.27 DLEU1
 deleted in lymphocytic leukemia 1 (non-protein coding)
 116486
 0.05
chr6_170501787_170501938 0.27 RP11-302L19.1
24121
 0.21
chr6_26296598_26296749 0.27 HIST1H4H
 histone cluster 1, H4h
 10911
 0.08
chr22_43411349_43411733 0.26 PACSIN2
 protein kinase C and casein kinase substrate in neurons 2
 390
 0.86
chr15_70147676_70147827 0.26 ENSG00000215958
 .
 69908
 0.12
chr17_73937351_73937691 0.26 FBF1
 Fas (TNFRSF6) binding factor 1
 402
 0.69
chr16_839632_839783 0.26 CHTF18
 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
 394
 0.62
chr9_137366473_137366866 0.26 RXRA
 retinoid X receptor, alpha
 68241
 0.11
chr14_56617754_56618009 0.26 PELI2
 pellino E3 ubiquitin protein ligase family member 2
 32054
 0.21
chr14_77773813_77773964 0.26 POMT2
 protein-O-mannosyltransferase 2
 12795
 0.12
chr8_122360906_122361134 0.26 ENSG00000221644
 .
 161888
 0.04
chr9_137250637_137250831 0.26 ENSG00000263897
 .
 20523
 0.22
chr15_82180102_82180253 0.26 ENSG00000222521
 .
 156458
 0.04
chr10_119303115_119303318 0.26 EMX2
 empty spiracles homeobox 2
 707
 0.63
chr6_151244201_151244352 0.25 ENSG00000202119
 .
 16082
 0.21
chr1_199403544_199403695 0.25 ENSG00000263805
 .
 180789
 0.03
chr19_50804315_50804466 0.25 CTB-191K22.5
9406
 0.12
chr5_74867541_74867832 0.25 POLK
 polymerase (DNA directed) kappa
 24838
 0.14
chr8_142143433_142143584 0.25 RP11-809O17.1
3448
 0.24
chr6_143388789_143389162 0.25 AIG1
 androgen-induced 1
 6937
 0.19
chr14_104018069_104018220 0.25 ENSG00000252469
 .
 1462
 0.17
chr19_5038576_5038872 0.25 KDM4B
 lysine (K)-specific demethylase 4B
 22388
 0.2
chr6_15090109_15090260 0.25 ENSG00000242989
 .
 23015
 0.23
chr11_126455523_126455674 0.25 KIRREL3-AS1
 KIRREL3 antisense RNA 1
 41756
 0.17
chr14_75687131_75687282 0.25 ENSG00000252013
 .
 18334
 0.14
chr3_142840553_142840704 0.25 CHST2
 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
 2455
 0.34
chr17_72837180_72837562 0.25 GRIN2C
 glutamate receptor, ionotropic, N-methyl D-aspartate 2C
 18627
 0.11
chr15_63526608_63526933 0.25 APH1B
 APH1B gamma secretase subunit
 41447
 0.14
chr8_56851680_56851967 0.24 LYN
 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
 970
 0.5
chr20_33301034_33301185 0.24 TP53INP2
 tumor protein p53 inducible nuclear protein 2
 8570
 0.21
chr15_43545776_43545927 0.24 ENSG00000202211
 .
 5973
 0.13
chr7_121170101_121170252 0.24 ENSG00000221690
 .
 44632
 0.19
chr1_86035839_86035990 0.24 DDAH1
 dimethylarginine dimethylaminohydrolase 1
 8019
 0.19
chr22_46501298_46501449 0.24 ENSG00000198986
 .
 7256
 0.1
chr17_1459503_1459654 0.24 PITPNA
 phosphatidylinositol transfer protein, alpha
 3212
 0.17
chr1_60598722_60598873 0.24 C1orf87
 chromosome 1 open reading frame 87
 59355
 0.16
chr3_58037044_58037226 0.24 FLNB
 filamin B, beta
 26921
 0.22
chr7_372645_372959 0.24 AC187652.1
 Protein LOC100996433
 69884
 0.12
chr1_156680056_156680253 0.24 RP11-66D17.5
2812
 0.13
chr5_1515989_1516747 0.24 LPCAT1
 lysophosphatidylcholine acyltransferase 1
 7724
 0.23
chr1_235104740_235105149 0.24 ENSG00000239690
 .
 65011
 0.12
chr19_7897788_7897939 0.24 EVI5L
 ecotropic viral integration site 5-like
 2744
 0.16
chr12_46782989_46783140 0.24 SLC38A2
 solute carrier family 38, member 2
 16414
 0.23
chr11_72295622_72295773 0.24 RP11-169D4.2
81
 0.64
chr13_110417364_110417521 0.24 IRS2
 insulin receptor substrate 2
 21473
 0.23
chr14_78266699_78267170 0.24 ADCK1
 aarF domain containing kinase 1
 452
 0.79
chr18_60118168_60118548 0.24 ZCCHC2
 zinc finger, CCHC domain containing 2
 71882
 0.1
chr19_632822_632973 0.23 POLRMT
 polymerase (RNA) mitochondrial (DNA directed)
 700
 0.47
chr17_29896770_29896921 0.23 AC003101.1
 Uncharacterized protein
 1316
 0.29
chr3_71591005_71591175 0.23 ENSG00000221264
 .
 150
 0.95
chr4_5748628_5748779 0.23 EVC
 Ellis van Creveld syndrome
 35761
 0.18
chr1_246599104_246599255 0.23 ENSG00000207326
 .
 9758
 0.22
chr3_178389375_178389526 0.23 KCNMB2
 potassium large conductance calcium-activated channel, subfamily M, beta member 2
 112832
 0.07
chr1_214668072_214668223 0.23 PTPN14
 protein tyrosine phosphatase, non-receptor type 14
 30001
 0.23
chr8_80681240_80681519 0.23 HEY1
 hes-related family bHLH transcription factor with YRPW motif 1
 1281
 0.55
chr19_19488516_19488930 0.23 GATAD2A
 GATA zinc finger domain containing 2A
 7912
 0.14
chr12_109080507_109080751 0.23 CORO1C
 coronin, actin binding protein, 1C
 9549
 0.15
chr13_32059321_32059637 0.23 RXFP2
 relaxin/insulin-like family peptide receptor 2
 254195
 0.02
chr9_90094686_90094877 0.23 DAPK1
 death-associated protein kinase 1
 17362
 0.26
chr6_6916729_6917061 0.23 ENSG00000240936
 .
 22235
 0.26
chr4_106227685_106227836 0.23 ENSG00000243383
 .
 12945
 0.26
chr2_43540601_43540961 0.23 AC010883.5
84069
 0.09
chr9_136923442_136923756 0.23 BRD3
 bromodomain containing 3
 2465
 0.24
chr7_14876053_14876204 0.23 DGKB
 diacylglycerol kinase, beta 90kDa
 4844
 0.27
chr17_71301605_71301911 0.23 CDC42EP4
 CDC42 effector protein (Rho GTPase binding) 4
 5789
 0.21
chr4_26220381_26220779 0.23 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 53649
 0.18
chr13_36849620_36849771 0.23 ENSG00000207203
 .
 8390
 0.15
chr17_68901911_68902062 0.23 ENSG00000238759
 .
 392373
 0.01
chr7_101705458_101705808 0.22 CTA-357J21.1
29330
 0.2
chr7_4832075_4832390 0.22 ENSG00000264474
 .
 3962
 0.18
chr2_48542892_48543532 0.22 FOXN2
 forkhead box N2
 1363
 0.5
chr3_187633047_187633241 0.22 BCL6
 B-cell CLL/lymphoma 6
 169629
 0.03
chr12_50362719_50362903 0.22 AQP6
 aquaporin 6, kidney specific
 1789
 0.21
chr10_31073518_31073669 0.22 RP11-330O11.3
48723
 0.15
chr10_17256968_17257119 0.22 VIM-AS1
 VIM antisense RNA 1
 11854
 0.15
chr10_90984522_90984806 0.22 CH25H
 cholesterol 25-hydroxylase
 17593
 0.15
chr1_25198988_25199139 0.22 RUNX3
 runt-related transcription factor 3
 56549
 0.12
chr10_104474502_104474843 0.22 SFXN2
 sideroflexin 2
 279
 0.68
chr17_79481237_79481485 0.22 RP13-766D20.2
288
 0.47
chr7_23250461_23250612 0.22 NUPL2
 nucleoporin like 2
 28853
 0.15
chr22_46299735_46299886 0.22 WNT7B
 wingless-type MMTV integration site family, member 7B
 68785
 0.09
chr4_48492543_48492694 0.22 ZAR1
 zygote arrest 1
 349
 0.89
chr5_14305370_14305521 0.22 TRIO
 trio Rho guanine nucleotide exchange factor
 14359
 0.31
chr2_27665478_27665738 0.22 KRTCAP3
 keratinocyte associated protein 3
 295
 0.81
chr12_18535849_18536000 0.22 PIK3C2G
 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
 100946
 0.09
chr11_67776489_67776640 0.22 ALDH3B1
 aldehyde dehydrogenase 3 family, member B1
 516
 0.66
chr8_54117831_54118132 0.22 RP11-162D9.3
27834
 0.21
chr17_19234995_19235146 0.22 RP11-135L13.4
4370
 0.13
chr8_130472580_130472731 0.22 ENSG00000263763
 .
 23733
 0.12

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB3L2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 0.2 GO:0046101 hypoxanthine biosynthetic process(GO:0046101)
0.1 0.2 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1 0.2 GO:0046185 aldehyde catabolic process(GO:0046185)
0.1 0.2 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.2 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
0.0 0.1 GO:1903504 positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:0071692 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.2 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.2 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618)
0.0 0.1 GO:0001821 histamine secretion(GO:0001821)
0.0 0.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.1 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.1 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.2 GO:0042416 dopamine biosynthetic process(GO:0042416)
0.0 0.2 GO:0031274 pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.2 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.2 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.1 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.2 GO:0016264 gap junction assembly(GO:0016264)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.5 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.0 GO:0000101 sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0 0.1 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0032906 transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909)
0.0 0.0 GO:0010193 response to ozone(GO:0010193)
0.0 0.1 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.0 0.1 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.0 0.2 GO:0007567 parturition(GO:0007567)
0.0 0.1 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 0.2 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.1 GO:0002604 dendritic cell antigen processing and presentation(GO:0002468) regulation of dendritic cell antigen processing and presentation(GO:0002604) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.1 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.0 0.1 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.1 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.1 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.1 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.1 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.1 GO:0021932 hindbrain radial glia guided cell migration(GO:0021932)
0.0 0.1 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.0 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.0 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.0 GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0 0.0 GO:0055089 fatty acid homeostasis(GO:0055089)
0.0 0.0 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0007090 obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0 0.0 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.0 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.0 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.0 GO:0010989 regulation of low-density lipoprotein particle clearance(GO:0010988) negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.0 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0 0.1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.0 GO:0070141 response to UV-A(GO:0070141)
0.0 0.2 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.0 GO:0060014 granulosa cell differentiation(GO:0060014)
0.0 0.0 GO:0014832 urinary bladder smooth muscle contraction(GO:0014832)
0.0 0.0 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.1 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.0 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.0 GO:0015824 proline transport(GO:0015824)
0.0 0.1 GO:0072501 cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.0 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.0 GO:0071800 podosome assembly(GO:0071800)
0.0 0.1 GO:2000144 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.0 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.0 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.0 GO:0090281 negative regulation of calcium ion import(GO:0090281)
0.0 0.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.1 GO:0048745 smooth muscle tissue development(GO:0048745)
0.0 0.0 GO:0043129 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.1 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.0 0.0 GO:0010984 regulation of lipoprotein particle clearance(GO:0010984)
0.0 0.0 GO:0009191 nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.1 GO:0050812 acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0 0.0 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:1903561 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0071546 pi-body(GO:0071546)
0.0 0.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.0 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.0 GO:0030904 retromer complex(GO:0030904)
0.0 0.1 GO:0030897 HOPS complex(GO:0030897)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.5 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.0 GO:0032059 bleb(GO:0032059)
0.0 0.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.3 GO:0043204 perikaryon(GO:0043204)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.1 GO:0016328 lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.2 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.1 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.1 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0052659 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0046980 tapasin binding(GO:0046980)
0.0 0.2 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.1 GO:0000987 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.3 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.0 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0031177 phosphopantetheine binding(GO:0031177)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.0 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.0 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.1 GO:0032052 bile acid binding(GO:0032052)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.0 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.0 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0051861 glycolipid binding(GO:0051861)
0.0 0.0 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0 0.0 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.0 GO:0033265 choline binding(GO:0033265)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 0.0 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.0 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.0 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.1 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.2 GO:0004675 transmembrane receptor protein serine/threonine kinase activity(GO:0004675)
0.0 0.0 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.0 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:0019894 kinesin binding(GO:0019894)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.0 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0051635 obsolete bacterial cell surface binding(GO:0051635)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 0.0 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.2 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.1 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.1 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts