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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for CREB3L2

Z-value: 1.06

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Transcription factors associated with CREB3L2

Gene Symbol	Gene ID	Gene Info
CREB3L2 Ensembl NCBI GeneCards UniProt	ENSG00000182158.10	CREB3L2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
CREB3L2	chr7_137668727_137668878	17991	0.183352	0.78	1.3e-02	Click!
CREB3L2	chr7_137663575_137663726	23143	0.172034	0.77	1.5e-02	Click!
CREB3L2	chr7_137573299_137573450	39641	0.153479	0.77	1.6e-02	Click!
CREB3L2	chr7_137605978_137606391	6831	0.230519	-0.77	1.6e-02	Click!
CREB3L2	chr7_137621255_137621573	2778	0.292325	0.74	2.2e-02	Click!

Activity of the CREB3L2 motif across conditions

Conditions sorted by the z-value of the CREB3L2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_16681395_16681795	0.77	RP1-151F17.1		79774	0.1
chr17_48718114_48718630	0.54	ABCC3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	6154	0.13
chr14_100906069_100906661	0.52	RP11-362L22.1		33123	0.1
chr15_68683192_68683351	0.49	ITGA11	integrin, alpha 11	41221	0.18
chr6_147235336_147235538	0.49	STXBP5-AS1	STXBP5 antisense RNA 1	1584	0.55
chr16_29167036_29167187	0.49	CTB-134H23.3		48345	0.11
chr8_126187977_126188128	0.49	NSMCE2	non-SMC element 2, MMS21 homolog (S. cerevisiae)	51666	0.14
chr4_129308818_129308969	0.46	PGRMC2	progesterone receptor membrane component 2	98909	0.09
chr9_137394449_137394849	0.44	RXRA	retinoid X receptor, alpha	96221	0.07
chr18_53398894_53399045	0.44	TCF4	transcription factor 4	66951	0.14
chr2_223574012_223574225	0.44	ENSG00000238852	.	11399	0.21
chr14_91281521_91281794	0.44	TTC7B	tetratricopeptide repeat domain 7B	1104	0.63
chr1_209831123_209831274	0.43	LAMB3	laminin, beta 3	5387	0.15
chr5_118733387_118734036	0.42	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	41981	0.13
chr10_1290240_1290555	0.42	ADARB2	adenosine deaminase, RNA-specific, B2 (non-functional)	44072	0.17
chr5_71475626_71475777	0.42	MAP1B	microtubule-associated protein 1B	246	0.94
chr21_35709927_35710173	0.41	KCNE2	potassium voltage-gated channel, Isk-related family, member 2	26273	0.13
chr7_141615794_141616062	0.40	OR9A4	olfactory receptor, family 9, subfamily A, member 4	2689	0.16
chr2_71682494_71682648	0.40	DYSF	dysferlin	1719	0.44
chr4_120986498_120987561	0.39	RP11-679C8.2		1084	0.42
chr22_42765026_42765177	0.38	TCF20	transcription factor 20 (AR1)	25479	0.18
chr9_94660876_94661276	0.38	ROR2	receptor tyrosine kinase-like orphan receptor 2	50086	0.18
chr21_30754344_30754495	0.38	ENSG00000239171	.	7391	0.18
chr6_42283087_42283238	0.38	ENSG00000221252	.	96972	0.06
chr10_79638365_79638516	0.38	AL391421.1	Uncharacterized protein; cDNA FLJ43696 fis, clone TBAES2007964	11807	0.18
chr3_139020939_139021090	0.38	MRPS22	mitochondrial ribosomal protein S22	41847	0.13
chr1_201237669_201237867	0.38	PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	14812	0.18
chr1_145526041_145526192	0.37	ITGA10	integrin, alpha 10	1081	0.31
chr1_8882630_8882823	0.37	RERE	arginine-glutamic acid dipeptide (RE) repeats	5024	0.19
chr16_11295208_11295453	0.37	RMI2	RecQ mediated genome instability 2	48176	0.08
chr15_77713627_77714545	0.37	HMG20A	high mobility group 20A	733	0.64
chr5_134773694_134773956	0.36	C5orf20	chromosome 5 open reading frame 20	9213	0.14
chr11_67896240_67896572	0.36	CTD-2655K5.1		859	0.55
chr3_29376763_29376914	0.36	ENSG00000216169	.	34074	0.18
chr18_22878825_22879093	0.36	CTD-2006O16.2		3131	0.37
chr6_52379346_52379497	0.36	TRAM2	translocation associated membrane protein 2	62292	0.12
chr15_35598915_35599148	0.36	ENSG00000265102	.	65534	0.14
chr2_112763039_112763349	0.35	MERTK	c-mer proto-oncogene tyrosine kinase	13796	0.22
chr20_25208276_25208481	0.35	AL035252.1	HCG2018895; Uncharacterized protein	1008	0.49
chr1_33849901_33850220	0.35	PHC2	polyhomeotic homolog 2 (Drosophila)	8866	0.16
chr1_59602387_59602647	0.35	FGGY	FGGY carbohydrate kinase domain containing	159793	0.04
chr6_145569007_145569263	0.34	ENSG00000221796	.	100759	0.09
chr10_134330476_134330668	0.34	LINC01165	long intergenic non-protein coding RNA 1165	5381	0.22
chr1_41467777_41468071	0.34	CTPS1	CTP synthase 1	19091	0.19
chr21_39660692_39660843	0.33	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	7712	0.29
chr16_72405306_72405606	0.33	ENSG00000207514	.	5147	0.31
chr12_48147567_48147718	0.33	SLC48A1	solute carrier family 48 (heme transporter), member 1	57	0.96
chr16_55530572_55531230	0.33	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	8327	0.22
chr6_13397775_13398015	0.33	GFOD1	glucose-fructose oxidoreductase domain containing 1	10474	0.21
chr14_61789232_61789447	0.33	PRKCH	protein kinase C, eta	43	0.71
chr15_90325381_90325563	0.32	MESP2	mesoderm posterior 2 homolog (mouse)	5883	0.14
chr6_82575347_82575498	0.32	ENSG00000206886	.	101681	0.07
chr4_57945352_57945503	0.32	ENSG00000238541	.	27084	0.14
chr18_56658261_56658433	0.32	ENSG00000251870	.	64819	0.11
chr1_107480050_107480201	0.32	PRMT6	protein arginine methyltransferase 6	119142	0.07
chr1_37920990_37921188	0.32	LINC01137	long intergenic non-protein coding RNA 1137	18923	0.15
chr2_112375416_112375598	0.31	ENSG00000266063	.	153204	0.04
chr12_124870235_124870636	0.31	NCOR2	nuclear receptor corepressor 2	2935	0.37
chr10_115821373_115821605	0.31	ADRB1	adrenoceptor beta 1	17683	0.2
chr1_33798502_33798653	0.31	ENSG00000266239	.	484	0.7
chr10_79291591_79291742	0.31	ENSG00000199592	.	55141	0.15
chr5_159698543_159698722	0.31	ENSG00000243654	.	20163	0.16
chr16_85424724_85424875	0.31	RP11-680G10.1	Uncharacterized protein	33730	0.18
chr3_122785668_122785819	0.31	PDIA5	protein disulfide isomerase family A, member 5	174	0.96
chr9_124051158_124051423	0.31	GSN	gelsolin	2420	0.21
chr10_102124571_102124984	0.31	SCD	stearoyl-CoA desaturase (delta-9-desaturase)	17896	0.13
chr9_6973383_6973534	0.30	KDM4C	lysine (K)-specific demethylase 4C	40330	0.2
chr11_69402239_69402390	0.30	CCND1	cyclin D1	53541	0.14
chr7_47616572_47616723	0.30	TNS3	tensin 3	4582	0.32
chr6_7921829_7921980	0.30	TXNDC5	thioredoxin domain containing 5 (endoplasmic reticulum)	10857	0.3
chr1_234688974_234689202	0.30	ENSG00000212144	.	39933	0.14
chr7_1595634_1595900	0.30	TMEM184A	transmembrane protein 184A	11	0.97
chr20_5844973_5845124	0.30	ENSG00000202380	.	25653	0.17
chr1_45793013_45793296	0.30	HPDL	4-hydroxyphenylpyruvate dioxygenase-like	609	0.67
chr13_20764967_20765118	0.30	GJB2	gap junction protein, beta 2, 26kDa	1123	0.49
chr17_75307827_75307996	0.29	SEPT9	septin 9	7686	0.23
chr1_15105044_15105255	0.29	KAZN	kazrin, periplakin interacting protein	145477	0.05
chr19_18959817_18960274	0.29	UPF1	UPF1 regulator of nonsense transcripts homolog (yeast)	17235	0.11
chr2_151337576_151337727	0.29	RND3	Rho family GTPase 3	4245	0.38
chr16_700261_700412	0.29	WDR90	WD repeat domain 90	919	0.22
chr17_75346852_75347029	0.29	SEPT9	septin 9	22332	0.16
chr1_27916174_27916325	0.29	AHDC1	AT hook, DNA binding motif, containing 1	13853	0.15
chr9_127030805_127030956	0.29	RP11-121A14.3		5725	0.18
chr4_69331756_69331907	0.29	TMPRSS11E	transmembrane protease, serine 11E	18664	0.25
chr8_18696899_18697278	0.29	PSD3	pleckstrin and Sec7 domain containing 3	14796	0.23
chr1_25040508_25040659	0.29	CLIC4	chloride intracellular channel 4	31265	0.15
chr12_14413818_14414239	0.29	ENSG00000251908	.	10753	0.22
chr21_40144936_40145370	0.29	ETS2	v-ets avian erythroblastosis virus E26 oncogene homolog 2	32078	0.22
chr20_30195413_30195568	0.29	ENSG00000264395	.	501	0.67
chr22_37958323_37958474	0.29	CDC42EP1	CDC42 effector protein (Rho GTPase binding) 1	1263	0.33
chr11_57282126_57282281	0.28	SLC43A1	solute carrier family 43 (amino acid system L transporter), member 1	115	0.93
chr5_114795818_114795969	0.28	FEM1C	fem-1 homolog c (C. elegans)	84698	0.08
chr13_98953540_98953691	0.28	FARP1	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	30397	0.16
chr16_3900112_3900331	0.28	CREBBP	CREB binding protein	29900	0.18
chr9_91390340_91390723	0.28	ENSG00000265873	.	29711	0.24
chr10_77471952_77472136	0.28	RP11-367B6.2		30454	0.19
chr1_9127158_9127594	0.28	SLC2A5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	2228	0.26
chr8_23396820_23397037	0.28	SLC25A37	solute carrier family 25 (mitochondrial iron transporter), member 37	10355	0.16
chr17_35534355_35534506	0.28	ACACA	acetyl-CoA carboxylase alpha	10804	0.24
chr5_14153391_14153542	0.28	TRIO	trio Rho guanine nucleotide exchange factor	9637	0.32
chr16_57411779_57412024	0.28	CX3CL1	chemokine (C-X3-C motif) ligand 1	1017	0.45
chr7_101688884_101689543	0.28	CTA-357J21.1		12910	0.24
chr9_138818669_138818820	0.28	RP11-432J22.2		19086	0.17
chr19_35939108_35939372	0.28	FFAR2	free fatty acid receptor 2	37	0.96
chr6_83075536_83075687	0.27	TPBG	trophoblast glycoprotein	1650	0.53
chr1_62070273_62070424	0.27	ENSG00000264551	.	24355	0.25
chrX_52964621_52965041	0.27	FAM156A	family with sequence similarity 156, member A	20698	0.18
chr9_109622867_109623098	0.27	ZNF462	zinc finger protein 462	2396	0.34
chr18_59658543_59658754	0.27	RNF152	ring finger protein 152	97184	0.08
chr17_76127130_76127305	0.27	TMC8	transmembrane channel-like 8	348	0.54
chr10_81160624_81160775	0.27	RP11-342M3.5		18615	0.19
chr13_50772718_50772869	0.27	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	116486	0.05
chr6_170501787_170501938	0.27	RP11-302L19.1		24121	0.21
chr6_26296598_26296749	0.27	HIST1H4H	histone cluster 1, H4h	10911	0.08
chr22_43411349_43411733	0.26	PACSIN2	protein kinase C and casein kinase substrate in neurons 2	390	0.86
chr15_70147676_70147827	0.26	ENSG00000215958	.	69908	0.12
chr17_73937351_73937691	0.26	FBF1	Fas (TNFRSF6) binding factor 1	402	0.69
chr16_839632_839783	0.26	CHTF18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	394	0.62
chr9_137366473_137366866	0.26	RXRA	retinoid X receptor, alpha	68241	0.11
chr14_56617754_56618009	0.26	PELI2	pellino E3 ubiquitin protein ligase family member 2	32054	0.21
chr14_77773813_77773964	0.26	POMT2	protein-O-mannosyltransferase 2	12795	0.12
chr8_122360906_122361134	0.26	ENSG00000221644	.	161888	0.04
chr9_137250637_137250831	0.26	ENSG00000263897	.	20523	0.22
chr15_82180102_82180253	0.26	ENSG00000222521	.	156458	0.04
chr10_119303115_119303318	0.26	EMX2	empty spiracles homeobox 2	707	0.63
chr6_151244201_151244352	0.25	ENSG00000202119	.	16082	0.21
chr1_199403544_199403695	0.25	ENSG00000263805	.	180789	0.03
chr19_50804315_50804466	0.25	CTB-191K22.5		9406	0.12
chr5_74867541_74867832	0.25	POLK	polymerase (DNA directed) kappa	24838	0.14
chr8_142143433_142143584	0.25	RP11-809O17.1		3448	0.24
chr6_143388789_143389162	0.25	AIG1	androgen-induced 1	6937	0.19
chr14_104018069_104018220	0.25	ENSG00000252469	.	1462	0.17
chr19_5038576_5038872	0.25	KDM4B	lysine (K)-specific demethylase 4B	22388	0.2
chr6_15090109_15090260	0.25	ENSG00000242989	.	23015	0.23
chr11_126455523_126455674	0.25	KIRREL3-AS1	KIRREL3 antisense RNA 1	41756	0.17
chr14_75687131_75687282	0.25	ENSG00000252013	.	18334	0.14
chr3_142840553_142840704	0.25	CHST2	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	2455	0.34
chr17_72837180_72837562	0.25	GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	18627	0.11
chr15_63526608_63526933	0.25	APH1B	APH1B gamma secretase subunit	41447	0.14
chr8_56851680_56851967	0.24	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	970	0.5
chr20_33301034_33301185	0.24	TP53INP2	tumor protein p53 inducible nuclear protein 2	8570	0.21
chr15_43545776_43545927	0.24	ENSG00000202211	.	5973	0.13
chr7_121170101_121170252	0.24	ENSG00000221690	.	44632	0.19
chr1_86035839_86035990	0.24	DDAH1	dimethylarginine dimethylaminohydrolase 1	8019	0.19
chr22_46501298_46501449	0.24	ENSG00000198986	.	7256	0.1
chr17_1459503_1459654	0.24	PITPNA	phosphatidylinositol transfer protein, alpha	3212	0.17
chr1_60598722_60598873	0.24	C1orf87	chromosome 1 open reading frame 87	59355	0.16
chr3_58037044_58037226	0.24	FLNB	filamin B, beta	26921	0.22
chr7_372645_372959	0.24	AC187652.1	Protein LOC100996433	69884	0.12
chr1_156680056_156680253	0.24	RP11-66D17.5		2812	0.13
chr5_1515989_1516747	0.24	LPCAT1	lysophosphatidylcholine acyltransferase 1	7724	0.23
chr1_235104740_235105149	0.24	ENSG00000239690	.	65011	0.12
chr19_7897788_7897939	0.24	EVI5L	ecotropic viral integration site 5-like	2744	0.16
chr12_46782989_46783140	0.24	SLC38A2	solute carrier family 38, member 2	16414	0.23
chr11_72295622_72295773	0.24	RP11-169D4.2		81	0.64
chr13_110417364_110417521	0.24	IRS2	insulin receptor substrate 2	21473	0.23
chr14_78266699_78267170	0.24	ADCK1	aarF domain containing kinase 1	452	0.79
chr18_60118168_60118548	0.24	ZCCHC2	zinc finger, CCHC domain containing 2	71882	0.1
chr19_632822_632973	0.23	POLRMT	polymerase (RNA) mitochondrial (DNA directed)	700	0.47
chr17_29896770_29896921	0.23	AC003101.1	Uncharacterized protein	1316	0.29
chr3_71591005_71591175	0.23	ENSG00000221264	.	150	0.95
chr4_5748628_5748779	0.23	EVC	Ellis van Creveld syndrome	35761	0.18
chr1_246599104_246599255	0.23	ENSG00000207326	.	9758	0.22
chr3_178389375_178389526	0.23	KCNMB2	potassium large conductance calcium-activated channel, subfamily M, beta member 2	112832	0.07
chr1_214668072_214668223	0.23	PTPN14	protein tyrosine phosphatase, non-receptor type 14	30001	0.23
chr8_80681240_80681519	0.23	HEY1	hes-related family bHLH transcription factor with YRPW motif 1	1281	0.55
chr19_19488516_19488930	0.23	GATAD2A	GATA zinc finger domain containing 2A	7912	0.14
chr12_109080507_109080751	0.23	CORO1C	coronin, actin binding protein, 1C	9549	0.15
chr13_32059321_32059637	0.23	RXFP2	relaxin/insulin-like family peptide receptor 2	254195	0.02
chr9_90094686_90094877	0.23	DAPK1	death-associated protein kinase 1	17362	0.26
chr6_6916729_6917061	0.23	ENSG00000240936	.	22235	0.26
chr4_106227685_106227836	0.23	ENSG00000243383	.	12945	0.26
chr2_43540601_43540961	0.23	AC010883.5		84069	0.09
chr9_136923442_136923756	0.23	BRD3	bromodomain containing 3	2465	0.24
chr7_14876053_14876204	0.23	DGKB	diacylglycerol kinase, beta 90kDa	4844	0.27
chr17_71301605_71301911	0.23	CDC42EP4	CDC42 effector protein (Rho GTPase binding) 4	5789	0.21
chr4_26220381_26220779	0.23	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	53649	0.18
chr13_36849620_36849771	0.23	ENSG00000207203	.	8390	0.15
chr17_68901911_68902062	0.23	ENSG00000238759	.	392373	0.01
chr7_101705458_101705808	0.22	CTA-357J21.1		29330	0.2
chr7_4832075_4832390	0.22	ENSG00000264474	.	3962	0.18
chr2_48542892_48543532	0.22	FOXN2	forkhead box N2	1363	0.5
chr3_187633047_187633241	0.22	BCL6	B-cell CLL/lymphoma 6	169629	0.03
chr12_50362719_50362903	0.22	AQP6	aquaporin 6, kidney specific	1789	0.21
chr10_31073518_31073669	0.22	RP11-330O11.3		48723	0.15
chr10_17256968_17257119	0.22	VIM-AS1	VIM antisense RNA 1	11854	0.15
chr10_90984522_90984806	0.22	CH25H	cholesterol 25-hydroxylase	17593	0.15
chr1_25198988_25199139	0.22	RUNX3	runt-related transcription factor 3	56549	0.12
chr10_104474502_104474843	0.22	SFXN2	sideroflexin 2	279	0.68
chr17_79481237_79481485	0.22	RP13-766D20.2		288	0.47
chr7_23250461_23250612	0.22	NUPL2	nucleoporin like 2	28853	0.15
chr22_46299735_46299886	0.22	WNT7B	wingless-type MMTV integration site family, member 7B	68785	0.09
chr4_48492543_48492694	0.22	ZAR1	zygote arrest 1	349	0.89
chr5_14305370_14305521	0.22	TRIO	trio Rho guanine nucleotide exchange factor	14359	0.31
chr2_27665478_27665738	0.22	KRTCAP3	keratinocyte associated protein 3	295	0.81
chr12_18535849_18536000	0.22	PIK3C2G	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	100946	0.09
chr11_67776489_67776640	0.22	ALDH3B1	aldehyde dehydrogenase 3 family, member B1	516	0.66
chr8_54117831_54118132	0.22	RP11-162D9.3		27834	0.21
chr17_19234995_19235146	0.22	RP11-135L13.4		4370	0.13
chr8_130472580_130472731	0.22	ENSG00000263763	.	23733	0.12

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB3L2

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.1	0.2	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.1	0.2	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1	0.2	GO:0046185	aldehyde catabolic process(GO:0046185)
0.1	0.2	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.2	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
0.0	0.1	GO:1903504	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.1	GO:0071692	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.2	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.2	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.2	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.1	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.2	GO:0042416	dopamine biosynthetic process(GO:0042416)
0.0	0.2	GO:0031274	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.2	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.2	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.1	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.2	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.5	GO:0018904	glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.0	GO:0000101	sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0	0.1	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0032906	transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909)
0.0	0.0	GO:0010193	response to ozone(GO:0010193)
0.0	0.1	GO:0033567	DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.2	GO:0007567	parturition(GO:0007567)
0.0	0.1	GO:0048311	mitochondrion distribution(GO:0048311)
0.0	0.2	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.1	GO:0002604	dendritic cell antigen processing and presentation(GO:0002468) regulation of dendritic cell antigen processing and presentation(GO:0002604) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:0070366	regulation of hepatocyte differentiation(GO:0070366)
0.0	0.1	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.1	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.1	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.1	GO:0021932	hindbrain radial glia guided cell migration(GO:0021932)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.0	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.0	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.0	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.0	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.0	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.0	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.0	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.0	GO:0010989	regulation of low-density lipoprotein particle clearance(GO:0010988) negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.1	GO:0051496	positive regulation of stress fiber assembly(GO:0051496)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.0	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.1	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0	0.0	GO:0070141	response to UV-A(GO:0070141)
0.0	0.2	GO:0045806	negative regulation of endocytosis(GO:0045806)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.0	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.0	GO:0014832	urinary bladder smooth muscle contraction(GO:0014832)
0.0	0.0	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.0	GO:0070365	hepatocyte differentiation(GO:0070365)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.0	GO:0015824	proline transport(GO:0015824)
0.0	0.1	GO:0072501	cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0	0.0	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.0	GO:0071800	podosome assembly(GO:0071800)
0.0	0.1	GO:2000144	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.0	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.0	GO:0090281	negative regulation of calcium ion import(GO:0090281)
0.0	0.3	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.0	0.1	GO:0048745	smooth muscle tissue development(GO:0048745)
0.0	0.0	GO:0043129	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.1	GO:2000272	negative regulation of receptor activity(GO:2000272)
0.0	0.0	GO:0010984	regulation of lipoprotein particle clearance(GO:0010984)
0.0	0.0	GO:0009191	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.1	GO:0050812	acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.0	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.1	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.1	GO:0070695	FHF complex(GO:0070695)
0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.1	GO:0042825	TAP complex(GO:0042825)
0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	GO:0071546	pi-body(GO:0071546)
0.2	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	GO:0030904	retromer complex(GO:0030904)
0.1	GO:0030897	HOPS complex(GO:0030897)
0.1	GO:0002102	podosome(GO:0002102)
0.2	GO:0000421	autophagosome membrane(GO:0000421)
0.5	GO:0008287	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.1	GO:0031941	filamentous actin(GO:0031941)
0.0	GO:0032059	bleb(GO:0032059)
0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.3	GO:0043204	perikaryon(GO:0043204)
0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.1	GO:0016328	lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1	0.2	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.2	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.1	GO:0016215	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.2	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.2	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.1	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0046980	tapasin binding(GO:0046980)
0.0	0.2	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0000987	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.2	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.3	GO:0003756	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	0.1	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.2	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0019238	cyclohydrolase activity(GO:0019238)
0.0	0.0	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.1	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.1	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.0	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0003747	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.1	GO:0032052	bile acid binding(GO:0032052)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.1	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.0	GO:0031127	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0051861	glycolipid binding(GO:0051861)
0.0	0.0	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.0	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.1	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.0	GO:0033265	choline binding(GO:0033265)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.0	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.0	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.0	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.1	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.0	0.2	GO:0004675	transmembrane receptor protein serine/threonine kinase activity(GO:0004675)
0.0	0.0	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.0	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0019894	kinesin binding(GO:0019894)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.0	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	0.3	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.5	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	0.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.0	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.0	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.2	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.0	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.2	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.2	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.3	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.1	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.1	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts