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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for CUX1

Z-value: 0.72

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Transcription factors associated with CUX1

Gene Symbol	Gene ID	Gene Info
CUX1 Ensembl NCBI GeneCards UniProt	ENSG00000257923.5	CUX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
CUX1	chr7_101388868_101389019	70016	0.105292	0.73	2.6e-02	Click!
CUX1	chr7_101378437_101378588	80447	0.089167	0.66	5.5e-02	Click!
CUX1	chr7_101438358_101438509	20526	0.207993	-0.60	8.5e-02	Click!
CUX1	chr7_101376791_101377001	82063	0.086907	0.57	1.1e-01	Click!
CUX1	chr7_101387918_101388069	70966	0.103709	0.56	1.2e-01	Click!

Activity of the CUX1 motif across conditions

Conditions sorted by the z-value of the CUX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr20_4356829_4357115	0.12	ADRA1D	adrenoceptor alpha 1D	127251	0.05
chr6_89504471_89504714	0.12	ENSG00000222145	.	80443	0.1
chr5_102780141_102780414	0.12	NUDT12	nudix (nucleoside diphosphate linked moiety X)-type motif 12	118213	0.06
chr5_77887462_77888069	0.11	LHFPL2	lipoma HMGIC fusion partner-like 2	42791	0.21
chr7_114628946_114629097	0.11	MDFIC	MyoD family inhibitor domain containing	55097	0.17
chr22_20777294_20777549	0.11	ENSG00000207343	.	6232	0.12
chr10_33529675_33530002	0.11	NRP1	neuropilin 1	22794	0.19
chr7_100411285_100411882	0.11	ENSG00000263672	.	7303	0.11
chr14_77511448_77512058	0.11	IRF2BPL	interferon regulatory factor 2 binding protein-like	16719	0.18
chr12_66322607_66323042	0.10	AC090673.2	Uncharacterized protein	4857	0.21
chr15_39696001_39696152	0.10	RP11-624L4.1		16834	0.27
chr2_113594705_113594960	0.10	IL1B	interleukin 1, beta	352	0.86
chr21_40378291_40378490	0.10	ENSG00000272015	.	111681	0.06
chr21_47485945_47486454	0.10	AP001471.1		31245	0.13
chr4_186651858_186652115	0.10	SORBS2	sorbin and SH3 domain containing 2	9498	0.21
chr5_159107_159571	0.09	ENSG00000199540	.	15027	0.14
chr7_54878481_54878866	0.09	SEC61G	Sec61 gamma subunit	51006	0.13
chr11_73174890_73175041	0.09	RP11-809N8.4		58623	0.1
chr6_136434664_136434859	0.09	PDE7B	phosphodiesterase 7B	35463	0.16
chr9_110037719_110038006	0.09	RAD23B	RAD23 homolog B (S. cerevisiae)	7556	0.31
chr1_245951430_245951581	0.09	RP11-522M21.3		111725	0.07
chr1_110476345_110476632	0.09	CSF1	colony stimulating factor 1 (macrophage)	22880	0.15
chr6_130644268_130644419	0.09	SAMD3	sterile alpha motif domain containing 3	42227	0.17
chr11_128442939_128443342	0.09	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	14313	0.23
chr9_16031542_16031875	0.09	C9orf92	chromosome 9 open reading frame 92	184189	0.03
chr20_11229977_11230245	0.09	C20orf187	chromosome 20 open reading frame 187	221300	0.02
chr17_26793910_26794378	0.09	SLC13A2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	6167	0.11
chr12_6198255_6198797	0.09	ENSG00000240533	.	6610	0.23
chr18_46354811_46355214	0.09	RP11-484L8.1		6129	0.29
chr7_2867050_2867285	0.08	GNA12	guanine nucleotide binding protein (G protein) alpha 12	12274	0.25
chr7_132004161_132004312	0.08	AC011625.1		32857	0.21
chr2_48795884_48796035	0.08	STON1-GTF2A1L	STON1-GTF2A1L readthrough	200	0.95
chr10_45476507_45476680	0.08	C10orf10	chromosome 10 open reading frame 10	2335	0.19
chr12_95597054_95597379	0.08	FGD6	FYVE, RhoGEF and PH domain containing 6	13939	0.18
chr2_121005547_121005698	0.08	RALB	v-ral simian leukemia viral oncogene homolog B	4712	0.21
chr4_140933484_140933746	0.08	RP11-392B6.1		115554	0.06
chr18_10479454_10479605	0.08	APCDD1	adenomatosis polyposis coli down-regulated 1	7696	0.26
chr1_66478233_66478531	0.08	PDE4B	phosphodiesterase 4B, cAMP-specific	20277	0.22
chr10_103295849_103296000	0.08	DPCD	deleted in primary ciliary dyskinesia homolog (mouse)	34482	0.14
chr10_88162815_88162966	0.08	GRID1	glutamate receptor, ionotropic, delta 1	36655	0.16
chr3_38871334_38871622	0.08	RP11-134J21.1		6085	0.2
chr10_112182641_112182792	0.08	ENSG00000221359	.	11283	0.22
chr5_94742657_94743120	0.08	FAM81B	family with sequence similarity 81, member B	15840	0.25
chr9_131905468_131905894	0.08	PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	1377	0.3
chr8_71060509_71060843	0.08	NCOA2	nuclear receptor coactivator 2	19	0.98
chr19_54023625_54024053	0.08	ZNF331	zinc finger protein 331	439	0.74
chr2_30834318_30834573	0.08	LCLAT1	lysocardiolipin acyltransferase 1	164176	0.04
chr2_216765021_216765281	0.08	ENSG00000212055	.	21509	0.25
chr22_22191485_22191760	0.08	MAPK1	mitogen-activated protein kinase 1	30108	0.12
chr9_16540961_16541659	0.08	RP11-183I6.2		68124	0.12
chr6_25168636_25168787	0.08	ENSG00000222373	.	23930	0.17
chr17_56582578_56582941	0.08	MTMR4	myotubularin related protein 4	8638	0.12
chr7_148410320_148410484	0.08	CUL1	cullin 1	14398	0.17
chr10_114719872_114720172	0.08	RP11-57H14.2		8388	0.22
chr9_117805131_117805394	0.08	TNC	tenascin C	21929	0.25
chr10_75924551_75924986	0.08	ADK	adenosine kinase	11676	0.2
chr18_43381728_43382214	0.07	SIGLEC15	sialic acid binding Ig-like lectin 15	23506	0.18
chr1_203020776_203021050	0.07	PPFIA4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	545	0.7
chr16_1521079_1521553	0.07	CLCN7	chloride channel, voltage-sensitive 7	641	0.43
chr2_177508527_177508764	0.07	ENSG00000252027	.	20759	0.27
chr5_94423327_94423550	0.07	MCTP1	multiple C2 domains, transmembrane 1	5850	0.32
chr3_10018102_10018700	0.07	EMC3	ER membrane protein complex subunit 3	9965	0.08
chr3_177549479_177549630	0.07	ENSG00000199858	.	176013	0.03
chr10_97047482_97047633	0.07	PDLIM1	PDZ and LIM domain 1	3224	0.31
chr20_44470840_44471081	0.07	SNX21	sorting nexin family member 21	8185	0.08
chr6_109663929_109664175	0.07	ENSG00000201023	.	37355	0.11
chr14_91305961_91306112	0.07	TTC7B	tetratricopeptide repeat domain 7B	23213	0.24
chr15_59588622_59588914	0.07	RP11-429D19.1		25407	0.13
chr2_8722437_8722588	0.07	AC011747.7		93384	0.09
chr9_94154220_94154371	0.07	AUH	AU RNA binding protein/enoyl-CoA hydratase	30100	0.21
chr7_101360762_101360997	0.07	MYL10	myosin, light chain 10, regulatory	88303	0.08
chr4_74844819_74845072	0.07	PF4	platelet factor 4	2896	0.19
chr6_7151631_7152228	0.07	RREB1	ras responsive element binding protein 1	12451	0.19
chr12_63253482_63253831	0.07	ENSG00000200296	.	8975	0.26
chr4_72271640_72271791	0.07	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	66945	0.14
chr7_26714510_26714661	0.07	C7orf71	chromosome 7 open reading frame 71	37095	0.2
chr13_27543257_27543411	0.07	USP12-AS1	USP12 antisense RNA 1	193658	0.02
chr10_14654331_14654637	0.07	FAM107B	family with sequence similarity 107, member B	67	0.98
chr1_235243157_235243394	0.07	ENSG00000207181	.	47977	0.13
chr9_110905251_110905592	0.07	ENSG00000222512	.	215788	0.02
chr7_47541782_47542068	0.07	TNS3	tensin 3	21042	0.28
chr1_81698308_81698583	0.07	ENSG00000223026	.	19029	0.27
chr10_3793162_3793446	0.07	RP11-184A2.3		45	0.98
chr2_62638288_62638545	0.07	ENSG00000241625	.	79897	0.09
chr2_171219129_171219280	0.07	AC012594.1		11576	0.29
chr7_149666181_149666332	0.07	ATP6V0E2-AS1	ATP6V0E2 antisense RNA 1	88557	0.08
chr1_9950424_9950885	0.07	CTNNBIP1	catenin, beta interacting protein 1	2641	0.21
chr2_224599920_224600071	0.07	AP1S3	adaptor-related protein complex 1, sigma 3 subunit	102206	0.08
chr2_192241823_192241993	0.07	ENSG00000252130	.	6244	0.26
chr8_101450194_101450600	0.07	KB-1615E4.2		37506	0.14
chr2_43188272_43188475	0.07	ENSG00000207087	.	130259	0.05
chr11_85658543_85658752	0.07	RP11-90K17.2		23922	0.18
chr4_140669620_140669850	0.07	ENSG00000252233	.	45852	0.14
chr6_42105086_42105410	0.07	C6orf132	chromosome 6 open reading frame 132	4934	0.17
chr1_85245912_85246495	0.07	ENSG00000251899	.	12679	0.24
chr5_39411390_39411705	0.07	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	13423	0.26
chr1_154703230_154703438	0.07	ADAR	adenosine deaminase, RNA-specific	102860	0.05
chr10_128111271_128111422	0.07	ADAM12	ADAM metallopeptidase domain 12	34322	0.19
chr3_128690038_128690295	0.07	RP11-723O4.6	Uncharacterized protein FLJ43738	7	0.97
chr10_72546347_72546498	0.07	TBATA	thymus, brain and testes associated	1265	0.51
chr3_138493910_138494448	0.07	PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	4782	0.31
chr12_13192614_13192765	0.07	KIAA1467	KIAA1467	4529	0.19
chr9_96902563_96902834	0.07	ENSG00000199165	.	35536	0.13
chr2_207387205_207387356	0.06	ADAM23	ADAM metallopeptidase domain 23	72279	0.1
chr3_141507253_141507404	0.06	ENSG00000265391	.	575	0.76
chr17_56454718_56454869	0.06	SUPT4H1	suppressor of Ty 4 homolog 1 (S. cerevisiae)	24339	0.1
chr2_106088158_106088309	0.06	FHL2	four and a half LIM domains 2	33263	0.2
chr18_10059619_10060204	0.06	ENSG00000263630	.	54717	0.15
chr9_7368414_7368565	0.06	KDM4C	lysine (K)-specific demethylase 4C	354701	0.01
chr2_47284996_47285404	0.06	AC073283.7		9761	0.19
chr22_32272417_32272584	0.06	DEPDC5	DEP domain containing 5	23598	0.15
chr10_43624518_43624697	0.06	CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	9327	0.24
chr3_72536153_72536343	0.06	RYBP	RING1 and YY1 binding protein	40179	0.18
chr1_90289087_90289450	0.06	LRRC8D	leucine rich repeat containing 8 family, member D	1788	0.4
chr1_161691025_161691176	0.06	FCRLB	Fc receptor-like B	253	0.86
chr4_157466044_157466305	0.06	RP11-171N4.2	Uncharacterized protein	97285	0.08
chr16_57798443_57798674	0.06	KIFC3	kinesin family member C3	257	0.89
chr12_11733293_11733560	0.06	ENSG00000251747	.	34013	0.16
chr7_148237394_148237545	0.06	C7orf33	chromosome 7 open reading frame 33	50188	0.15
chr3_11186255_11186406	0.06	HRH1	histamine receptor H1	7551	0.29
chr2_65025641_65026023	0.06	ENSG00000239891	.	18680	0.17
chr15_82420642_82420851	0.06	RP11-597K23.2	Uncharacterized protein	39714	0.14
chr10_115753299_115753721	0.06	ADRB1	adrenoceptor beta 1	50296	0.13
chr4_171593437_171593770	0.06	ENSG00000251961	.	219015	0.02
chr22_37845321_37845613	0.06	ELFN2	extracellular leucine-rich repeat and fibronectin type III domain containing 2	21962	0.12
chr8_104122247_104122563	0.06	KB-1639H6.4		10855	0.13
chr12_31515195_31515657	0.06	ENSG00000207477	.	3796	0.2
chr7_5676160_5676311	0.06	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	41918	0.12
chr5_14203788_14204073	0.06	TRIO	trio Rho guanine nucleotide exchange factor	20023	0.29
chr3_51655634_51655948	0.06	RAD54L2	RAD54-like 2 (S. cerevisiae)	7616	0.17
chr9_94579747_94580327	0.06	ROR2	receptor tyrosine kinase-like orphan receptor 2	131125	0.05
chr1_82172157_82172358	0.06	LPHN2	latrophilin 2	6802	0.31
chr5_95630062_95630271	0.06	ENSG00000206997	.	84235	0.09
chr22_46403312_46403647	0.06	WNT7B	wingless-type MMTV integration site family, member 7B	30470	0.1
chr8_98992108_98992483	0.06	MATN2	matrilin 2	18585	0.17
chr15_101656285_101656543	0.06	RP11-505E24.2		30143	0.19
chr4_116135456_116135745	0.06	NDST4	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	100568	0.09
chr1_153493498_153493653	0.06	BX470102.3		12504	0.08
chr2_44315981_44316132	0.06	ENSG00000252599	.	65978	0.1
chr2_218793055_218793347	0.06	TNS1	tensin 1	8269	0.24
chr1_152010963_152011114	0.06	S100A11	S100 calcium binding protein A11	1527	0.33
chr10_90188173_90188378	0.06	RNLS	renalase, FAD-dependent amine oxidase	154672	0.04
chr21_40144936_40145370	0.06	ETS2	v-ets avian erythroblastosis virus E26 oncogene homolog 2	32078	0.22
chr2_118981232_118982329	0.06	INSIG2	insulin induced gene 2	135730	0.05
chr10_80714020_80714184	0.06	ZMIZ1-AS1	ZMIZ1 antisense RNA 1	8049	0.31
chr3_5051196_5051347	0.06	BHLHE40-AS1	BHLHE40 antisense RNA 1	29625	0.16
chr2_33714938_33715089	0.06	RASGRP3	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	13297	0.26
chr2_65587328_65587537	0.06	SPRED2	sprouty-related, EVH1 domain containing 2	6352	0.24
chr7_105793652_105793945	0.06	SYPL1	synaptophysin-like 1	40776	0.17
chr12_13256087_13256238	0.06	GSG1	germ cell associated 1	414	0.86
chr14_72409694_72409937	0.06	RGS6	regulator of G-protein signaling 6	9866	0.26
chr3_119355128_119355463	0.06	POPDC2	popeye domain containing 2	24142	0.13
chr1_115969093_115969306	0.06	ENSG00000265534	.	59073	0.13
chr3_23780848_23781065	0.06	ENSG00000238672	.	28146	0.18
chr10_108696078_108696229	0.06	ENSG00000200626	.	33626	0.25
chr1_200201358_200201523	0.06	ENSG00000221403	.	87478	0.09
chr4_57157705_57157856	0.06	ENSG00000252489	.	3030	0.25
chr12_65700883_65701407	0.06	MSRB3	methionine sulfoxide reductase B3	19510	0.22
chr8_59507659_59507955	0.06	SDCBP	syndecan binding protein (syntenin)	30232	0.19
chr1_83615938_83616104	0.06	ENSG00000223231	.	643539	0.0
chr8_108395540_108395691	0.06	ANGPT1	angiopoietin 1	46865	0.2
chr12_94821583_94821926	0.06	CCDC41	coiled-coil domain containing 41	31968	0.18
chr11_33905413_33905728	0.06	AC132216.1	HCG1785179; PRO1787; Uncharacterized protein	3381	0.25
chr10_49679111_49679316	0.06	ARHGAP22	Rho GTPase activating protein 22	19543	0.21
chr4_86713761_86713912	0.06	ARHGAP24	Rho GTPase activating protein 24	13977	0.26
chr17_40244674_40244825	0.06	DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58	19732	0.09
chr8_25991226_25991377	0.06	ENSG00000199620	.	3095	0.37
chr1_184611707_184611858	0.06	ENSG00000252790	.	35286	0.21
chr10_114817495_114817718	0.06	TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	86073	0.09
chr12_89764903_89765288	0.06	DUSP6	dual specificity phosphatase 6	18047	0.24
chr16_15687209_15687510	0.06	CTB-193M12.1		14972	0.15
chr15_71341987_71342266	0.06	THSD4	thrombospondin, type I, domain containing 4	47165	0.15
chr1_33854701_33854997	0.06	PHC2	polyhomeotic homolog 2 (Drosophila)	13655	0.15
chr10_77468463_77468644	0.06	RP11-367B6.2		33945	0.18
chr16_57671396_57671547	0.06	GPR56	G protein-coupled receptor 56	1736	0.28
chr15_74721212_74721414	0.06	SEMA7A	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	4688	0.16
chr4_8228081_8228232	0.06	SH3TC1	SH3 domain and tetratricopeptide repeats 1	10226	0.22
chr3_123725960_123726111	0.06	ROPN1	rhophilin associated tail protein 1	15010	0.2
chr1_204407416_204407567	0.06	PPP1R15B	protein phosphatase 1, regulatory subunit 15B	26572	0.15
chr10_80176666_80176817	0.06	ENSG00000201393	.	49477	0.19
chr2_165748011_165748162	0.06	ENSG00000223318	.	4201	0.21
chr16_73097967_73098118	0.06	ZFHX3	zinc finger homeobox 3	4445	0.27
chr16_73221207_73221358	0.06	C16orf47	chromosome 16 open reading frame 47	42936	0.2
chr10_14782963_14783114	0.06	FAM107B	family with sequence similarity 107, member B	33858	0.17
chr21_39856205_39856389	0.06	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	14048	0.3
chr17_76140274_76140656	0.06	C17orf99	chromosome 17 open reading frame 99	1969	0.2
chr5_148799600_148799798	0.06	ENSG00000208035	.	8782	0.14
chr1_221334892_221335132	0.06	HLX	H2.0-like homeobox	280428	0.01
chr3_194944977_194945345	0.06	ENSG00000206600	.	9645	0.17
chr2_11837137_11837372	0.06	AC106875.1		15667	0.12
chr7_47497450_47497661	0.06	TNS3	tensin 3	4726	0.35
chr22_35863792_35863943	0.06	MCM5	minichromosome maintenance complex component 5	67443	0.1
chr15_101628578_101628729	0.06	RP11-505E24.2		2382	0.35
chr2_109779392_109779641	0.06	ENSG00000264934	.	21472	0.22
chr8_9018614_9018765	0.06	RP11-10A14.4	Uncharacterized protein	9376	0.17
chr2_152191078_152191290	0.06	TNFAIP6	tumor necrosis factor, alpha-induced protein 6	22922	0.15
chr12_89555329_89555814	0.06	ENSG00000238302	.	120491	0.06
chr17_13447545_13447833	0.06	ENSG00000221698	.	726	0.71
chr4_74975264_74975487	0.06	CXCL2	chemokine (C-X-C motif) ligand 2	10365	0.16
chr2_105271366_105271517	0.06	ENSG00000207249	.	78251	0.09

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of CUX1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0010193	response to ozone(GO:0010193)
0.0	0.1	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.1	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.0	GO:0042637	catagen(GO:0042637)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.0	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.2	GO:0043277	apoptotic cell clearance(GO:0043277)
0.0	0.0	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.2	GO:0002040	sprouting angiogenesis(GO:0002040)
0.0	0.0	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.0	GO:0071692	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.0	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.0	GO:0060174	limb bud formation(GO:0060174)
0.0	0.0	GO:0061001	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907) positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0	0.1	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.0	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.0	GO:0042109	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.0	GO:0051014	actin filament severing(GO:0051014)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.0	GO:0033091	positive regulation of immature T cell proliferation(GO:0033091)
0.0	0.0	GO:0046113	nucleobase catabolic process(GO:0046113)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0003321	positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.0	GO:0060737	prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.0	GO:0072311	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0035413	positive regulation of catenin import into nucleus(GO:0035413)
0.0	0.0	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.0	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.0	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.0	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.0	GO:0043457	regulation of cellular respiration(GO:0043457)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	GO:0005915	zonula adherens(GO:0005915)
0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	GO:0033268	node of Ranvier(GO:0033268)
0.1	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.0	GO:0001740	Barr body(GO:0001740)
0.1	GO:0001527	microfibril(GO:0001527)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.1	GO:0000987	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	GO:0003680	AT DNA binding(GO:0003680)
0.0	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	GO:0045545	syndecan binding(GO:0045545)
0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	GO:0004111	creatine kinase activity(GO:0004111)
0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	GO:0019763	immunoglobulin receptor activity(GO:0019763)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	Genes involved in Phospholipase C-mediated cascade
0.0	0.0	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0	0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction