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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for DDIT3

Z-value: 1.77

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Transcription factors associated with DDIT3

Gene Symbol Gene ID Gene Info
DDIT3
ENSG00000175197.6 DNA damage inducible transcript 3

Activity of the DDIT3 motif across conditions

Conditions sorted by the z-value of the DDIT3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr12_66289441_66289878 1.17 RP11-366L20.2
 Uncharacterized protein
 13712
 0.17
chr9_84106067_84106472 1.01 TLE1
 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
 122168
 0.06
chr20_23238843_23239098 0.99 NXT1
 NTF2-like export factor 1
 92403
 0.05
chr11_43529872_43530198 0.94 ENSG00000211568
 .
 51171
 0.12
chr2_145402982_145403264 0.88 ZEB2
 zinc finger E-box binding homeobox 2
 124502
 0.06
chr8_62630791_62631038 0.87 ENSG00000264408
 .
 3567
 0.27
chr6_18216555_18216818 0.82 KDM1B
 lysine (K)-specific demethylase 1B
 30667
 0.15
chr7_17408913_17409156 0.81 ENSG00000199473
 .
 3916
 0.32
chr2_113998730_113999135 0.80 PAX8
 paired box 8
 328
 0.68
chr2_127934430_127934663 0.77 CYP27C1
 cytochrome P450, family 27, subfamily C, polypeptide 1
 28797
 0.2
chr10_93884742_93884893 0.76 ENSG00000264076
 .
 34512
 0.16
chr2_12959099_12960371 0.76 ENSG00000264370
 .
 82242
 0.11
chr5_77889982_77890133 0.74 LHFPL2
 lipoma HMGIC fusion partner-like 2
 45083
 0.2
chr13_42270469_42270620 0.74 ENSG00000241406
 .
 111269
 0.06
chr1_232840317_232840703 0.73 ENSG00000238382
 .
 4560
 0.32
chr3_30333675_30334003 0.72 ENSG00000199927
 .
 12188
 0.3
chr7_77082891_77083367 0.72 ENSG00000238453
 .
 30024
 0.19
chr20_30198397_30198778 0.70 ENSG00000264395
 .
 3598
 0.15
chr11_34586202_34586499 0.69 ELF5
 E74-like factor 5 (ets domain transcription factor)
 50998
 0.14
chr4_170187898_170188049 0.68 SH3RF1
 SH3 domain containing ring finger 1
 3135
 0.35
chr21_44141550_44141701 0.67 AP001627.1
20243
 0.2
chr10_95193664_95193870 0.67 MYOF
 myoferlin
 48184
 0.14
chr4_13921909_13922060 0.67 ENSG00000252092
 .
 261733
 0.02
chr2_26981199_26981390 0.65 SLC35F6
 solute carrier family 35, member F6
 5862
 0.19
chr15_73979466_73979617 0.65 CD276
 CD276 molecule
 2194
 0.36
chr3_128914988_128915202 0.64 CNBP
 CCHC-type zinc finger, nucleic acid binding protein
 12330
 0.14
chr16_88058565_88058905 0.64 BANP
 BTG3 associated nuclear protein
 55111
 0.14
chr1_42083758_42083983 0.63 RP11-486B10.3
82756
 0.09
chr14_51404344_51404736 0.62 PYGL
 phosphorylase, glycogen, liver
 6634
 0.19
chr2_26232303_26232586 0.62 AC013449.1
 Uncharacterized protein
 19037
 0.15
chr2_162969937_162970139 0.62 GCG
 glucagon
 38875
 0.13
chr3_134050665_134050816 0.62 AMOTL2
 angiomotin like 2
 40014
 0.16
chr2_146996340_146996491 0.62 ENSG00000251905
 .
 93691
 0.1
chr10_74084780_74085101 0.62 DNAJB12
 DnaJ (Hsp40) homolog, subfamily B, member 12
 19779
 0.16
chr13_106770061_106770212 0.62 ENSG00000222643
 .
 10584
 0.27
chr8_116461452_116461961 0.61 TRPS1
 trichorhinophalangeal syndrome I
 42742
 0.19
chr11_58733011_58733162 0.61 RP11-142C4.6
13672
 0.16
chr3_133289241_133289476 0.61 CDV3
 CDV3 homolog (mouse)
 3216
 0.26
chr4_86953575_86953726 0.60 RP13-514E23.1
18623
 0.19
chr13_45389687_45389838 0.60 NUFIP1
 nuclear fragile X mental retardation protein interacting protein 1
 173856
 0.03
chr5_34487322_34487473 0.60 RAI14
 retinoic acid induced 14
 168945
 0.03
chr3_14246546_14246821 0.60 XPC
 xeroderma pigmentosum, complementation group C
 26400
 0.16
chr7_16697056_16697503 0.59 BZW2
 basic leucine zipper and W2 domains 2
 3569
 0.24
chr1_56981658_56981809 0.59 PPAP2B
 phosphatidic acid phosphatase type 2B
 63508
 0.14
chr1_201681170_201681321 0.59 ENSG00000264802
 .
 7391
 0.14
chr2_216765021_216765281 0.58 ENSG00000212055
 .
 21509
 0.25
chr20_10286775_10287859 0.58 ENSG00000211588
 .
 55561
 0.13
chr7_38784313_38784750 0.58 VPS41
 vacuolar protein sorting 41 homolog (S. cerevisiae)
 631
 0.81
chr6_155815833_155816170 0.58 NOX3
 NADPH oxidase 3
 38964
 0.21
chr1_86038271_86038452 0.58 DDAH1
 dimethylarginine dimethylaminohydrolase 1
 5572
 0.2
chr5_151043511_151043918 0.58 CTB-113P19.4
11878
 0.14
chr2_40544107_40544258 0.57 AC007377.1
56035
 0.15
chr11_57045647_57045894 0.56 APLNR
 apelin receptor
 41095
 0.09
chr1_56278160_56278311 0.56 PIGQP1
 phosphatidylinositol glycan anchor biosynthesis, class Q pseudogene 1
 126718
 0.06
chr1_204381057_204381208 0.56 PPP1R15B
 protein phosphatase 1, regulatory subunit 15B
 213
 0.94
chr9_72619163_72619314 0.56 MAMDC2
 MAM domain containing 2
 39259
 0.18
chr2_9374494_9374810 0.55 ASAP2
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
 27758
 0.24
chr4_157672395_157672563 0.55 RP11-154F14.2
90032
 0.08
chr15_63232625_63232776 0.55 RP11-1069G10.1
56467
 0.12
chr6_138231300_138231872 0.55 RP11-356I2.4
42216
 0.16
chr17_43407056_43407601 0.55 ENSG00000199953
 .
 2465
 0.22
chr12_52077625_52077776 0.55 SCN8A
 sodium channel, voltage gated, type VIII, alpha subunit
 2507
 0.37
chr7_137627516_137627793 0.55 CREB3L2
 cAMP responsive element binding protein 3-like 2
 9018
 0.21
chr6_7975682_7975960 0.54 TXNDC5
 thioredoxin domain containing 5 (endoplasmic reticulum)
 50825
 0.16
chr14_85983042_85983193 0.54 RP11-497E19.2
 Uncharacterized protein
 11826
 0.25
chr5_169002894_169003181 0.53 SPDL1
 spindle apparatus coiled-coil protein 1
 7601
 0.23
chr5_37771599_37771776 0.53 ENSG00000238335
 .
 30480
 0.2
chr8_129071045_129071196 0.53 ENSG00000221176
 .
 9722
 0.21
chr11_58394708_58394859 0.53 CNTF
 ciliary neurotrophic factor
 4637
 0.18
chr3_154736890_154737041 0.52 MME
 membrane metallo-endopeptidase
 4948
 0.35
chrX_68357539_68357690 0.52 PJA1
 praja ring finger 1, E3 ubiquitin protein ligase
 24923
 0.27
chr5_65543145_65543296 0.52 ENSG00000238400
 .
 16160
 0.26
chr3_171528829_171529427 0.51 PLD1
 phospholipase D1, phosphatidylcholine-specific
 844
 0.52
chr21_43518310_43518552 0.51 C21orf128
 chromosome 21 open reading frame 128
 10213
 0.19
chr5_90421803_90421954 0.51 ENSG00000199643
 .
 144666
 0.05
chr10_128947522_128947673 0.51 FAM196A
 family with sequence similarity 196, member A
 27676
 0.24
chr6_13762651_13763628 0.51 MCUR1
 mitochondrial calcium uniporter regulator 1
 38438
 0.15
chr4_39152584_39152984 0.50 RP11-360F5.1
24346
 0.17
chr10_116755757_116755908 0.50 ENSG00000252611
 .
 26505
 0.22
chr1_64211693_64212078 0.50 ROR1
 receptor tyrosine kinase-like orphan receptor 1
 27808
 0.21
chr5_64496427_64496578 0.50 ENSG00000207439
 .
 77306
 0.12
chr8_22811234_22811445 0.50 ENSG00000240116
 .
 24051
 0.12
chr12_72104450_72104601 0.50 TMEM19
 transmembrane protein 19
 13293
 0.18
chr3_114326741_114326892 0.50 ZBTB20
 zinc finger and BTB domain containing 20
 16237
 0.28
chr1_201595609_201595975 0.50 NAV1
 neuron navigator 1
 3191
 0.21
chr13_76290473_76290624 0.50 LMO7
 LIM domain 7
 43955
 0.16
chr1_155618391_155618704 0.49 YY1AP1
 YY1 associated protein 1
 27915
 0.11
chr15_42222648_42223001 0.49 CTD-2382E5.4
9209
 0.12
chr14_95130458_95130609 0.49 SERPINA13P
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 13, pseudogene
 22878
 0.19
chr1_11218024_11218175 0.49 ENSG00000253086
 .
 5692
 0.12
chr9_108004052_108004203 0.49 SLC44A1
 solute carrier family 44 (choline transporter), member 1
 2776
 0.4
chr10_81161241_81161392 0.49 RP11-342M3.5
19232
 0.18
chr3_188014840_188014991 0.48 LPP
 LIM domain containing preferred translocation partner in lipoma
 57263
 0.15
chr11_122577004_122577557 0.48 ENSG00000239079
 .
 19739
 0.22
chr4_143345126_143345417 0.48 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 7141
 0.35
chr10_17041586_17041737 0.48 CUBN
 cubilin (intrinsic factor-cobalamin receptor)
 15467
 0.27
chr11_86658361_86658657 0.48 FZD4
 frizzled family receptor 4
 7924
 0.24
chr13_34527970_34528121 0.47 ENSG00000263663
 .
 41916
 0.2
chr11_112031799_112032015 0.47 IL18
 interleukin 18 (interferon-gamma-inducing factor)
 2890
 0.14
chr14_52847171_52847322 0.47 PTGER2
 prostaglandin E receptor 2 (subtype EP2), 53kDa
 66133
 0.12
chr9_111274185_111274336 0.47 ENSG00000222512
 .
 153051
 0.04
chr13_110746918_110747075 0.47 ENSG00000265885
 .
 3502
 0.37
chr6_155384408_155384559 0.47 TIAM2
 T-cell lymphoma invasion and metastasis 2
 26940
 0.24
chr5_67192624_67192790 0.47 ENSG00000223149
 .
 70566
 0.14
chr17_62843312_62843537 0.47 PLEKHM1P
 pleckstrin homology domain containing, family M (with RUN domain) member 1 pseudogene
 10181
 0.12
chr1_201728441_201728592 0.47 NAV1
 neuron navigator 1
 19520
 0.11
chr6_11207055_11207535 0.47 NEDD9
 neural precursor cell expressed, developmentally down-regulated 9
 25596
 0.18
chr7_130934065_130934342 0.47 MKLN1
 muskelin 1, intracellular mediator containing kelch motifs
 35618
 0.2
chr1_181472407_181472558 0.47 CACNA1E
 calcium channel, voltage-dependent, R type, alpha 1E subunit
 19601
 0.29
chr10_54207743_54207894 0.46 RP11-556E13.1
113047
 0.07
chr1_101616339_101616490 0.46 ENSG00000252765
 .
 17705
 0.19
chr11_128778051_128778202 0.46 C11orf45
 chromosome 11 open reading frame 45
 2196
 0.25
chr17_8762469_8762816 0.46 PIK3R6
 phosphoinositide-3-kinase, regulatory subunit 6
 8352
 0.2
chr11_125491960_125492111 0.46 CHEK1
 checkpoint kinase 1
 3001
 0.18
chr17_42852393_42852858 0.46 ADAM11
 ADAM metallopeptidase domain 11
 15932
 0.13
chr14_74529404_74529555 0.45 ALDH6A1
 aldehyde dehydrogenase 6 family, member A1
 6482
 0.15
chr6_155545820_155546032 0.45 TIAM2
 T-cell lymphoma invasion and metastasis 2
 7826
 0.22
chr3_9464516_9464980 0.45 ENSG00000266001
 .
 3286
 0.2
chr18_46074818_46074969 0.45 CTIF
 CBP80/20-dependent translation initiation factor
 8427
 0.26
chr2_242318795_242318946 0.45 FARP2
 FERM, RhoGEF and pleckstrin domain protein 2
 6606
 0.17
chr8_89293881_89294032 0.45 RP11-586K2.1
45109
 0.17
chr2_174889480_174890119 0.45 SP3
 Sp3 transcription factor
 59369
 0.15
chr2_38403806_38403957 0.45 ENSG00000199603
 .
 29324
 0.19
chr9_124051991_124052278 0.45 GSN
 gelsolin
 3264
 0.18
chr9_124991658_124991809 0.45 LHX6
 LIM homeobox 6
 513
 0.73
chr5_14217746_14217971 0.44 TRIO
 trio Rho guanine nucleotide exchange factor
 33951
 0.25
chr8_37382286_37382454 0.44 RP11-150O12.6
7831
 0.28
chr10_80886709_80887280 0.44 ZMIZ1
 zinc finger, MIZ-type containing 1
 58202
 0.14
chr7_13937610_13937761 0.44 ETV1
 ets variant 1
 88381
 0.1
chr1_61629231_61629382 0.44 RP4-802A10.1
38901
 0.19
chr10_4125908_4126059 0.44 KLF6
 Kruppel-like factor 6
 298510
 0.01
chr12_89728661_89728921 0.44 DUSP6
 dual specificity phosphatase 6
 16157
 0.24
chr2_197848755_197848906 0.44 ANKRD44
 ankyrin repeat domain 44
 16396
 0.24
chr17_40111299_40111636 0.44 CNP
 2',3'-cyclic nucleotide 3' phosphodiesterase
 7292
 0.12
chr14_59366227_59366378 0.43 ENSG00000221427
 .
 128338
 0.06
chr6_56508196_56508347 0.43 DST
 dystonin
 477
 0.89
chr3_98575105_98575256 0.43 DCBLD2
 discoidin, CUB and LCCL domain containing 2
 44835
 0.12
chr10_28976434_28976585 0.43 BAMBI
 BMP and activin membrane-bound inhibitor
 10238
 0.19
chr6_14355332_14355483 0.43 ENSG00000238987
 .
 198714
 0.03
chr12_27265988_27266204 0.43 C12orf71
 chromosome 12 open reading frame 71
 30649
 0.19
chr20_56292850_56293001 0.43 PMEPA1
 prostate transmembrane protein, androgen induced 1
 6384
 0.28
chr5_136899404_136899555 0.43 ENSG00000221612
 .
 30336
 0.19
chr2_55327280_55327923 0.43 ENSG00000266376
 .
 8245
 0.2
chr9_112857746_112857955 0.42 AKAP2
 A kinase (PRKA) anchor protein 2
 5373
 0.31
chr19_47487906_47488096 0.42 NPAS1
 neuronal PAS domain protein 1
 35076
 0.12
chr5_71448848_71449179 0.42 ENSG00000264099
 .
 16281
 0.23
chr3_171704686_171704902 0.42 FNDC3B
 fibronectin type III domain containing 3B
 52624
 0.15
chr16_54495686_54495837 0.42 ENSG00000264079
 .
 87547
 0.1
chr4_22476411_22476562 0.42 GPR125
 G protein-coupled receptor 125
 1045
 0.7
chr12_46824110_46824422 0.42 SLC38A2
 solute carrier family 38, member 2
 57616
 0.14
chr10_90411662_90411938 0.42 LIPF
 lipase, gastric
 12398
 0.19
chr2_137948320_137948471 0.41 THSD7B
 thrombospondin, type I, domain containing 7B
 134121
 0.06
chr8_19963280_19963431 0.41 AC100802.3
26539
 0.21
chr1_214688078_214688229 0.41 PTPN14
 protein tyrosine phosphatase, non-receptor type 14
 36413
 0.21
chr13_52422853_52423004 0.41 CCDC70
 coiled-coil domain containing 70
 13189
 0.2
chr7_51097140_51097291 0.41 RP4-724E13.2
12055
 0.29
chr8_80260993_80261144 0.41 ENSG00000264969
 .
 251470
 0.02
chr2_213707871_213708022 0.41 ENSG00000221388
 .
 79547
 0.1
chr1_64434982_64435133 0.41 ENSG00000207190
 .
 59615
 0.14
chr2_121946677_121947036 0.41 TFCP2L1
 transcription factor CP2-like 1
 95927
 0.08
chr1_32255908_32256059 0.41 RP11-84A19.3
1252
 0.38
chr6_134085744_134085895 0.41 RP3-323P13.2
2927
 0.39
chr3_197193061_197193212 0.40 BDH1
 3-hydroxybutyrate dehydrogenase, type 1
 48130
 0.15
chr6_169692535_169692779 0.40 THBS2
 thrombospondin 2
 38518
 0.21
chr20_21413887_21414038 0.40 ENSG00000223128
 .
 8283
 0.2
chr15_80843805_80843956 0.40 RP11-379K22.2
11405
 0.18
chr2_19141790_19141941 0.40 NT5C1B
 5'-nucleotidase, cytosolic IB
 371027
 0.01
chr17_62258202_62258353 0.40 TEX2
 testis expressed 2
 31802
 0.13
chr1_214838419_214838570 0.40 CENPF
 centromere protein F, 350/400kDa
 61956
 0.15
chr2_38417733_38417884 0.40 ENSG00000199603
 .
 43251
 0.16
chr13_81043785_81043936 0.40 ENSG00000202398
 .
 100191
 0.09
chr6_147233902_147234394 0.40 STXBP5-AS1
 STXBP5 antisense RNA 1
 1406
 0.59
chr10_79346896_79347047 0.39 ENSG00000199592
 .
 164
 0.97
chr13_31293057_31293208 0.39 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 16513
 0.26
chr19_13162140_13162330 0.39 AC007787.2
19953
 0.09
chr14_75163942_75164093 0.39 ENSG00000222604
 .
 14637
 0.13
chr4_84482718_84482982 0.39 AGPAT9
 1-acylglycerol-3-phosphate O-acyltransferase 9
 25286
 0.2
chr1_87804199_87804350 0.39 LMO4
 LIM domain only 4
 6923
 0.31
chr5_124392361_124392578 0.39 ENSG00000222107
 .
 294355
 0.01
chr6_135820174_135820347 0.39 AHI1
 Abelson helper integration site 1
 1346
 0.52
chr18_56247923_56248074 0.39 ENSG00000252284
 .
 19865
 0.14
chr2_182239852_182240051 0.39 ENSG00000266705
 .
 69572
 0.12
chr14_32346804_32346955 0.39 RP11-187E13.1
 Uncharacterized protein
 67180
 0.12
chr19_2524912_2525063 0.39 ENSG00000252962
 .
 21848
 0.14
chr3_149096434_149096694 0.39 TM4SF1-AS1
 TM4SF1 antisense RNA 1
 558
 0.59
chr14_59338271_59338558 0.39 ENSG00000221427
 .
 100450
 0.08
chr8_38896239_38896390 0.39 ENSG00000207199
 .
 20112
 0.16
chr5_142051517_142051668 0.39 FGF1
 fibroblast growth factor 1 (acidic)
 13645
 0.21
chr2_144711038_144711196 0.38 AC016910.1
16477
 0.25
chr11_121986232_121986383 0.38 BLID
 BH3-like motif containing, cell death inducer
 616
 0.47
chr11_27483936_27484329 0.38 RP11-159H22.2
9144
 0.17
chr6_4320523_4320712 0.38 ENSG00000201185
 .
 107580
 0.07
chr11_123381605_123382192 0.38 GRAMD1B
 GRAM domain containing 1B
 14446
 0.23
chr5_122451826_122451977 0.38 AC106786.1
25907
 0.15
chr6_138174614_138174765 0.38 RP11-356I2.4
4496
 0.25
chr12_12377622_12377773 0.38 ENSG00000199551
 .
 1911
 0.38
chr4_139184776_139184927 0.38 SLC7A11
 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
 21348
 0.27
chr1_215130772_215131126 0.38 KCNK2
 potassium channel, subfamily K, member 2
 48249
 0.2
chr5_169372946_169373097 0.38 FAM196B
 family with sequence similarity 196, member B
 34723
 0.2
chr2_202270772_202271289 0.38 ENSG00000202008
 .
 17206
 0.15

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.1 0.3 GO:0021853 interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.1 0.3 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
0.1 0.2 GO:2000143 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.1 0.2 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 0.2 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.1 0.3 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.1 0.2 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 0.2 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.1 0.2 GO:0010715 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1 0.2 GO:0010842 retina layer formation(GO:0010842)
0.1 0.2 GO:0035581 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.6 GO:0006983 ER overload response(GO:0006983)
0.1 0.2 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 0.2 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.1 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.1 0.2 GO:0001714 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.3 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0032344 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.6 GO:0030878 thyroid gland development(GO:0030878)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0032898 neurotrophin production(GO:0032898)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.2 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.1 GO:0002540 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.3 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.0 GO:0031392 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.1 GO:0048840 otolith development(GO:0048840)
0.0 0.1 GO:0090116 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0060841 venous blood vessel development(GO:0060841)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.2 GO:0042253 granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253)
0.0 0.1 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.1 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.2 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.1 GO:0021843 substrate-independent telencephalic tangential migration(GO:0021826) substrate-independent telencephalic tangential interneuron migration(GO:0021843)
0.0 0.1 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.0 GO:0033091 positive regulation of immature T cell proliferation(GO:0033091)
0.0 0.1 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.1 GO:0019859 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.0 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0 0.1 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618) regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.1 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.2 GO:0006734 NADH metabolic process(GO:0006734)
0.0 0.1 GO:0009189 deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0 0.1 GO:0071221 response to bacterial lipoprotein(GO:0032493) response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.0 0.2 GO:0010225 response to UV-C(GO:0010225)
0.0 0.1 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.0 0.4 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.2 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.1 GO:0017085 response to insecticide(GO:0017085)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0051584 regulation of neurotransmitter uptake(GO:0051580) regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940)
0.0 0.2 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.0 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
0.0 0.1 GO:0006530 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0 0.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.5 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 0.1 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.2 GO:0030146 obsolete diuresis(GO:0030146)
0.0 0.1 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.1 GO:0014832 urinary bladder smooth muscle contraction(GO:0014832)
0.0 0.1 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.2 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.1 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.0 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.0 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.0 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0 0.2 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 0.1 GO:0003356 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) cilium movement involved in cell motility(GO:0060294) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0 0.1 GO:0002551 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0016246 RNA interference(GO:0016246)
0.0 0.0 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.0 0.2 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.2 GO:0090659 adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.1 GO:0031062 positive regulation of histone methylation(GO:0031062)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.0 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.0 GO:0060900 embryonic camera-type eye formation(GO:0060900)
0.0 0.2 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:0032099 negative regulation of appetite(GO:0032099)
0.0 0.0 GO:0044320 cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0 0.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.1 GO:0060539 diaphragm development(GO:0060539)
0.0 0.1 GO:0010658 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.1 GO:0043206 extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0 0.0 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.1 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.0 GO:0051532 NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0 0.1 GO:0021670 lateral ventricle development(GO:0021670)
0.0 0.0 GO:1903960 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0 0.1 GO:0001967 suckling behavior(GO:0001967)
0.0 0.0 GO:0045759 negative regulation of action potential(GO:0045759)
0.0 0.1 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.2 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.0 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.0 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.0 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.0 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.1 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.0 GO:0045986 negative regulation of smooth muscle contraction(GO:0045986)
0.0 0.1 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.0 GO:0090232 positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.0 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.1 GO:0071320 cellular response to cAMP(GO:0071320)
0.0 0.1 GO:0032801 receptor catabolic process(GO:0032801)
0.0 0.1 GO:0042693 muscle cell fate commitment(GO:0042693)
0.0 0.1 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 0.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.2 GO:0035329 hippo signaling(GO:0035329)
0.0 0.0 GO:0009191 nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.1 GO:0006927 obsolete transformed cell apoptotic process(GO:0006927)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.2 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0 0.1 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.1 GO:0007567 parturition(GO:0007567)
0.0 0.0 GO:0021591 ventricular system development(GO:0021591)
0.0 0.1 GO:0014037 Schwann cell differentiation(GO:0014037)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.0 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.0 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.0 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.1 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.0 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0033005 positive regulation of mast cell activation(GO:0033005)
0.0 0.1 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.0 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.0 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.0 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.0 GO:0072311 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.0 GO:0032060 bleb assembly(GO:0032060)
0.0 0.1 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.0 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.0 0.0 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.0 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.0 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0 0.0 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.0 0.0 GO:0042109 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.0 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.0 GO:0030573 bile acid catabolic process(GO:0030573)
0.0 0.0 GO:0070141 response to UV-A(GO:0070141)
0.0 0.0 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.0 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.0 0.0 GO:0060039 pericardium development(GO:0060039)
0.0 0.1 GO:0007603 phototransduction, visible light(GO:0007603)
0.0 0.1 GO:0002070 epithelial cell maturation(GO:0002070)
0.0 0.0 GO:0009130 pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130)
0.0 0.1 GO:0000768 syncytium formation by plasma membrane fusion(GO:0000768)
0.0 0.0 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
0.0 0.0 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.0 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.0 GO:0051934 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0 0.0 GO:0061072 iris morphogenesis(GO:0061072)
0.0 0.1 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.0 0.0 GO:0010873 positive regulation of cholesterol esterification(GO:0010873)
0.0 0.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0008634 obsolete negative regulation of survival gene product expression(GO:0008634)
0.0 0.0 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.1 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0 0.1 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.0 0.0 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.0 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.0 GO:0070254 mucus secretion(GO:0070254)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.2 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.2 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0016600 flotillin complex(GO:0016600)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.2 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.1 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.1 GO:0042584 chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.5 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.1 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0 0.2 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 1.3 GO:0030027 lamellipodium(GO:0030027)
0.0 0.0 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.1 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.0 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.0 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.0 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0002080 acrosomal membrane(GO:0002080)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.3 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 0.2 GO:0034648 histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.1 0.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.2 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.1 0.2 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.2 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.2 GO:0032190 acrosin binding(GO:0032190)
0.1 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.3 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.1 GO:0002060 purine nucleobase binding(GO:0002060)
0.0 0.3 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.3 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.0 GO:0050542 icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.2 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.2 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.0 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.2 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0043734 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.4 GO:0045296 cadherin binding(GO:0045296)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0022821 potassium ion antiporter activity(GO:0022821)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.0 GO:0050543 icosatetraenoic acid binding(GO:0050543)
0.0 0.1 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.0 0.1 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.1 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.2 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 0.2 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.0 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.0 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.0 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.1 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.0 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.0 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 0.0 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.0 GO:0034584 piRNA binding(GO:0034584)
0.0 0.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.0 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.1 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.0 GO:0052659 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.1 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.0 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.0 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.0 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.1 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.1 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.1 GO:0070888 E-box binding(GO:0070888)
0.0 0.0 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.0 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.0 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.0 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.0 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.0 GO:0070324 thyroid hormone binding(GO:0070324)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.1 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.7 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.0 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.1 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.0 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.4 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.1 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.1 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.3 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.0 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.1 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.0 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.0 0.0 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.0 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0 0.1 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.3 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.1 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.1 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.0 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.0 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.0 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions