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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for DLX3_EVX1_MEOX1

Z-value: 0.49

Motif logo

Transcription factors associated with DLX3_EVX1_MEOX1

Gene Symbol	Gene ID	Gene Info
DLX3 Ensembl NCBI GeneCards UniProt	ENSG00000064195.7	DLX3
EVX1 Ensembl NCBI GeneCards UniProt	ENSG00000106038.8	EVX1
MEOX1 Ensembl NCBI GeneCards UniProt	ENSG00000005102.8	MEOX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
DLX3	chr17_48072953_48073104	440	0.786378	-0.53	1.4e-01	Click!
DLX3	chr17_48098459_48098610	25946	0.117708	-0.51	1.6e-01	Click!
DLX3	chr17_48065557_48065736	5421	0.160487	-0.45	2.3e-01	Click!
DLX3	chr17_48066991_48067142	4001	0.176193	-0.44	2.3e-01	Click!
DLX3	chr17_48067814_48067965	3178	0.194847	-0.43	2.5e-01	Click!
EVX1	chr7_27277820_27277971	4269	0.117139	-0.87	2.4e-03	Click!
EVX1	chr7_27265056_27265207	17033	0.078925	-0.60	9.0e-02	Click!
EVX1	chr7_27264732_27264980	17308	0.078408	0.52	1.5e-01	Click!
EVX1	chr7_27281956_27282140	116	0.843438	0.30	4.4e-01	Click!
EVX1	chr7_27275467_27275717	6572	0.102937	0.28	4.6e-01	Click!
MEOX1	chr17_41758579_41758730	19332	0.152783	-0.91	7.5e-04	Click!
MEOX1	chr17_41773724_41773941	34510	0.114495	-0.85	3.4e-03	Click!
MEOX1	chr17_41774123_41774274	34876	0.113573	-0.81	8.1e-03	Click!
MEOX1	chr17_41773565_41773716	34318	0.114979	-0.79	1.1e-02	Click!
MEOX1	chr17_41778897_41779096	39674	0.101761	-0.77	1.5e-02	Click!

Activity of the DLX3_EVX1_MEOX1 motif across conditions

Conditions sorted by the z-value of the DLX3_EVX1_MEOX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_20015723_20015939	0.29	HTR6	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	24051	0.16
chr2_143918611_143918880	0.29	RP11-190J23.1		10996	0.25
chr13_46893880_46894070	0.29	ENSG00000223336	.	54750	0.1
chr1_200987046_200987749	0.25	KIF21B	kinesin family member 21B	5139	0.21
chr2_43402387_43402951	0.24	ZFP36L2	ZFP36 ring finger protein-like 2	51079	0.14
chr4_78721201_78721381	0.24	CNOT6L	CCR4-NOT transcription complex, subunit 6-like	18926	0.25
chr2_175207474_175207756	0.23	AC018470.1	Uncharacterized protein FLJ46347	5464	0.18
chr8_127567681_127568033	0.23	RP11-103H7.5		1284	0.38
chr13_50144464_50144942	0.21	RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	3244	0.28
chr8_118531704_118531855	0.21	MED30	mediator complex subunit 30	1173	0.66
chr1_25887348_25887770	0.20	LDLRAP1	low density lipoprotein receptor adaptor protein 1	17488	0.19
chr4_14996539_14996690	0.20	CPEB2	cytoplasmic polyadenylation element binding protein 2	7684	0.31
chr1_89338434_89338585	0.18	GTF2B	general transcription factor IIB	18670	0.19
chr14_99665484_99665650	0.18	AL162151.4		40814	0.17
chr3_152898855_152899006	0.18	ENSG00000265813	.	18876	0.19
chr9_71633765_71634208	0.18	PRKACG	protein kinase, cAMP-dependent, catalytic, gamma	4947	0.24
chr8_96174564_96174728	0.17	PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2	28342	0.18
chrX_154473029_154473180	0.17	RAB39B	RAB39B, member RAS oncogene family	20770	0.15
chr4_140724600_140724880	0.17	ENSG00000252233	.	9153	0.26
chr3_180322342_180322530	0.17	TTC14	tetratricopeptide repeat domain 14	2086	0.3
chr11_94960792_94960943	0.17	RP11-712B9.2		2483	0.31
chr1_168501039_168501303	0.17	XCL2	chemokine (C motif) ligand 2	12064	0.25
chr2_101977462_101977622	0.17	CREG2	cellular repressor of E1A-stimulated genes 2	26515	0.17
chr11_67170134_67170292	0.17	PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	811	0.3
chr16_384366_384517	0.16	AXIN1	axin 1	18008	0.1
chr9_130904274_130904425	0.16	LCN2	lipocalin 2	7001	0.09
chr6_4790828_4790979	0.16	CDYL	chromodomain protein, Y-like	14234	0.22
chr2_204726088_204726239	0.16	CTLA4	cytotoxic T-lymphocyte-associated protein 4	6346	0.27
chr12_111613238_111613505	0.16	CUX2	cut-like homeobox 2	76121	0.1
chr1_100821699_100821850	0.16	CDC14A	cell division cycle 14A	3269	0.24
chr15_91108604_91108755	0.16	CRTC3	CREB regulated transcription coactivator 3	28266	0.14
chr17_42574366_42574517	0.16	GPATCH8	G patch domain containing 8	6318	0.19
chr1_143741628_143741785	0.16	RP6-206I17.4		22002	0.16
chr8_126285678_126285829	0.16	ENSG00000242170	.	2907	0.35
chr1_85354747_85355038	0.15	LPAR3	lysophosphatidic acid receptor 3	4004	0.29
chr14_92973076_92973375	0.15	RIN3	Ras and Rab interactor 3	6893	0.29
chr1_147929159_147929310	0.15	PPIAL4A	peptidylprolyl isomerase A (cyclophilin A)-like 4A	26185	0.15
chr9_33976084_33976235	0.15	UBAP2	ubiquitin associated protein 2	12882	0.13
chr5_130706488_130706854	0.15	CDC42SE2	CDC42 small effector 2	14628	0.29
chr13_41574006_41574157	0.15	ELF1	E74-like factor 1 (ets domain transcription factor)	17663	0.19
chr5_34001933_34002084	0.15	AMACR	alpha-methylacyl-CoA racemase	6125	0.2
chr5_130849058_130849272	0.15	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	5315	0.33
chr1_151996398_151996549	0.15	S100A11	S100 calcium binding protein A11	13038	0.14
chr6_90989536_90989687	0.15	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	16850	0.23
chr2_171985361_171985646	0.15	ENSG00000238567	.	17337	0.23
chr20_50129553_50129706	0.15	NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	29629	0.21
chrX_11784442_11784722	0.15	MSL3	male-specific lethal 3 homolog (Drosophila)	6835	0.32
chr17_63024647_63024798	0.15	RP11-583F2.5		23305	0.15
chr19_39127082_39127242	0.15	ACTN4	actinin, alpha 4	11148	0.11
chr8_71111947_71112098	0.15	NCOA2	nuclear receptor coactivator 2	45588	0.17
chr17_75317102_75317253	0.15	SEPT9	septin 9	782	0.69
chr14_99707548_99707699	0.15	AL109767.1		21662	0.2
chr10_126630439_126630590	0.14	ZRANB1	zinc finger, RAN-binding domain containing 1	178	0.94
chr1_169663386_169663580	0.14	SELL	selectin L	17356	0.18
chr1_90290727_90290878	0.14	LRRC8D	leucine rich repeat containing 8 family, member D	3322	0.28
chr1_175124219_175124377	0.14	KIAA0040	KIAA0040	37592	0.18
chr6_16132777_16133009	0.14	MYLIP	myosin regulatory light chain interacting protein	3491	0.22
chr12_93778833_93779048	0.14	NUDT4	nudix (nucleoside diphosphate linked moiety X)-type motif 4	6510	0.16
chr8_129566610_129566901	0.14	ENSG00000221351	.	265285	0.02
chr8_96150775_96150926	0.14	PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2	4546	0.24
chr6_87872093_87872244	0.14	ZNF292	zinc finger protein 292	6829	0.2
chr14_76032303_76032574	0.14	FLVCR2	feline leukemia virus subgroup C cellular receptor family, member 2	12522	0.16
chr7_21405981_21406526	0.14	ENSG00000195024	.	14728	0.23
chr12_104940888_104941108	0.14	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	41628	0.17
chr20_44634089_44634268	0.14	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	3369	0.16
chr3_56844963_56845119	0.14	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	9046	0.29
chr5_156695529_156695722	0.14	CYFIP2	cytoplasmic FMR1 interacting protein 2	737	0.55
chr10_62954984_62955245	0.14	RHOBTB1	Rho-related BTB domain containing 1	193916	0.03
chr12_47600641_47601211	0.14	PCED1B	PC-esterase domain containing 1B	9126	0.22
chr5_175036653_175036804	0.14	ENSG00000222111	.	18463	0.21
chr15_60107360_60107511	0.14	BNIP2	BCL2/adenovirus E1B 19kDa interacting protein 2	125702	0.05
chr3_187971650_187971801	0.14	LPP	LIM domain containing preferred translocation partner in lipoma	14073	0.27
chr17_28067929_28068080	0.14	RP11-82O19.1		20117	0.14
chr1_152365758_152366013	0.14	RP1-91G5.3		19455	0.13
chr15_51568678_51568829	0.13	RP11-108K3.3		3459	0.23
chr2_102328256_102328453	0.13	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	13362	0.29
chr7_135655824_135656276	0.13	MTPN	myotrophin	6014	0.18
chr12_12856735_12856886	0.13	GPR19	G protein-coupled receptor 19	7669	0.15
chr18_74805340_74805625	0.13	MBP	myelin basic protein	11735	0.29
chr11_128496159_128496310	0.13	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	38781	0.15
chr7_97792627_97792778	0.13	BHLHA15	basic helix-loop-helix family, member a15	48037	0.13
chr1_115009857_115010035	0.13	TRIM33	tripartite motif containing 33	3898	0.27
chr10_8286078_8286310	0.13	GATA3	GATA binding protein 3	189425	0.03
chr5_39163760_39163964	0.13	FYB	FYN binding protein	39267	0.18
chr2_64342417_64342568	0.13	AC074289.1		27881	0.19
chrX_10126940_10127091	0.13	CLCN4	chloride channel, voltage-sensitive 4	443	0.87
chr12_95196521_95196672	0.13	ENSG00000208038	.	31578	0.23
chr19_39686992_39687200	0.13	NCCRP1	non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)	505	0.69
chr2_26096243_26096394	0.13	ASXL2	additional sex combs like 2 (Drosophila)	5017	0.29
chr14_99726122_99726406	0.13	AL109767.1		3021	0.29
chr14_96984501_96984733	0.13	PAPOLA	poly(A) polymerase alpha	9162	0.19
chr9_77743638_77743789	0.13	OSTF1	osteoclast stimulating factor 1	40254	0.13
chr14_81998709_81999052	0.13	SEL1L	sel-1 suppressor of lin-12-like (C. elegans)	1297	0.61
chr15_76933945_76934096	0.13	ENSG00000266449	.	55032	0.15
chr2_172008488_172008813	0.13	ENSG00000238567	.	5810	0.25
chr14_68974321_68974560	0.13	RAD51B	RAD51 paralog B	96213	0.08
chr5_173313190_173313341	0.13	CPEB4	cytoplasmic polyadenylation element binding protein 4	2018	0.44
chr11_10822167_10822423	0.13	EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	266	0.79
chr3_101440503_101440752	0.13	CEP97	centrosomal protein 97kDa	2142	0.24
chr17_5077650_5077801	0.13	ZNF594	zinc finger protein 594	9967	0.12
chr10_35301342_35301493	0.13	CUL2	cullin 2	58850	0.1
chr1_151024007_151024158	0.13	C1orf56	chromosome 1 open reading frame 56	3866	0.1
chr16_84769322_84769473	0.13	USP10	ubiquitin specific peptidase 10	32474	0.16
chr17_75869292_75869566	0.13	FLJ45079		9230	0.24
chrX_44757083_44757315	0.13	ENSG00000252113	.	12448	0.21
chr12_4394750_4395246	0.13	CCND2-AS1	CCND2 antisense RNA 1	9648	0.16
chr5_56024755_56025049	0.13	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	86499	0.08
chr13_32616590_32616779	0.13	FRY-AS1	FRY antisense RNA 1	10908	0.22
chrX_19823671_19823848	0.12	SH3KBP1	SH3-domain kinase binding protein 1	5890	0.31
chr7_150329628_150329863	0.12	GIMAP6	GTPase, IMAP family member 6	272	0.92
chr11_60250640_60250791	0.12	MS4A12	membrane-spanning 4-domains, subfamily A, member 12	9536	0.16
chr2_152510948_152511099	0.12	NEB	nebulin	70890	0.13
chr1_223314553_223314781	0.12	TLR5	toll-like receptor 5	1913	0.48
chr6_35700974_35701173	0.12	RP3-510O8.4		3651	0.14
chr7_42962275_42962426	0.12	PSMA2	proteasome (prosome, macropain) subunit, alpha type, 2	9423	0.19
chr14_99703175_99703515	0.12	AL109767.1		25940	0.19
chr2_96907290_96907448	0.12	TMEM127	transmembrane protein 127	18964	0.12
chr2_205942725_205942950	0.12	PARD3B	par-3 family cell polarity regulator beta	532114	0.0
chr16_53482763_53482914	0.12	RP11-44F14.5		178	0.9
chr14_38547030_38547196	0.12	CTD-2058B24.2		13250	0.26
chr11_128644263_128644414	0.12	FLI1	Fli-1 proto-oncogene, ETS transcription factor	9653	0.22
chr1_111439380_111439531	0.12	CD53	CD53 molecule	23679	0.15
chr5_75600048_75600202	0.12	RP11-466P24.6		7162	0.3
chr3_137935329_137935480	0.12	ARMC8	armadillo repeat containing 8	7074	0.23
chr3_171130059_171130210	0.12	ENSG00000222506	.	27181	0.21
chr5_159461944_159462095	0.12	TTC1	tetratricopeptide repeat domain 1	8121	0.21
chr22_41251648_41251915	0.12	ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	1179	0.3
chr11_118109489_118109640	0.12	MPZL3	myelin protein zero-like 3	13498	0.13
chr20_58625758_58625909	0.12	C20orf197	chromosome 20 open reading frame 197	5147	0.27
chr17_47407103_47407254	0.12	ENSG00000251964	.	3915	0.17
chr6_120063458_120063609	0.12	ENSG00000265725	.	272792	0.02
chr3_52235256_52235407	0.12	ALAS1	aminolevulinate, delta-, synthase 1	3171	0.15
chr18_43236719_43236870	0.12	SLC14A2	solute carrier family 14 (urea transporter), member 2	9313	0.2
chr2_99335771_99335922	0.12	MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	7313	0.25
chr14_36988822_36989041	0.12	NKX2-1	NK2 homeobox 1	33	0.88
chr1_87082986_87083335	0.12	ENSG00000221702	.	11120	0.18
chr10_8585757_8585908	0.12	ENSG00000212505	.	112962	0.07
chr6_154555947_154556098	0.12	IPCEF1	interaction protein for cytohesin exchange factors 1	11968	0.31
chr17_4297572_4297951	0.12	UBE2G1	ubiquitin-conjugating enzyme E2G 1	27838	0.13
chr14_65192092_65192622	0.12	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	1858	0.39
chr1_155190483_155190634	0.12	GBAP1	glucosidase, beta, acid pseudogene 1	1893	0.12
chr22_27066729_27066953	0.12	CRYBA4	crystallin, beta A4	48913	0.13
chr13_21048550_21048701	0.12	ENSG00000263978	.	40640	0.16
chr12_44224852_44225136	0.12	TMEM117	transmembrane protein 117	4892	0.24
chr14_98641364_98641616	0.12	ENSG00000222066	.	156597	0.04
chr2_85204305_85204589	0.12	KCMF1	potassium channel modulatory factor 1	5123	0.25
chr12_117959445_117959596	0.12	RP11-227B21.2		68703	0.13
chr7_37011204_37011355	0.12	ELMO1	engulfment and cell motility 1	13386	0.2
chr6_159223106_159223347	0.12	EZR-AS1	EZR antisense RNA 1	15817	0.16
chr5_140864104_140864255	0.12	PCDHGC4	protocadherin gamma subfamily C, 4	562	0.55
chr6_119226723_119226983	0.12	ASF1A	anti-silencing function 1A histone chaperone	11469	0.19
chr16_73092870_73093114	0.11	ZFHX3	zinc finger homeobox 3	605	0.79
chr2_174756889_174757040	0.11	SP3	Sp3 transcription factor	71983	0.13
chr7_105919723_105919874	0.11	NAMPT	nicotinamide phosphoribosyltransferase	5569	0.23
chr3_41245206_41245357	0.11	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	3679	0.39
chr11_48078680_48078903	0.11	ENSG00000263693	.	39543	0.14
chr1_121295339_121295490	0.11	FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)	359477	0.01
chr4_38518191_38518342	0.11	RP11-617D20.1		107930	0.07
chr12_46614859_46615010	0.11	SLC38A1	solute carrier family 38, member 1	46550	0.19
chr20_56969877_56970028	0.11	VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	5583	0.26
chr1_235439552_235439703	0.11	GGPS1	geranylgeranyl diphosphate synthase 1	51038	0.11
chr1_172597329_172597480	0.11	ENSG00000251943	.	14730	0.22
chr9_92078215_92078535	0.11	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	7507	0.25
chr13_49484698_49484849	0.11	ENSG00000265585	.	19575	0.22
chr19_6065223_6065413	0.11	CTC-232P5.3		2646	0.21
chr15_83733229_83733380	0.11	BTBD1	BTB (POZ) domain containing 1	2599	0.17
chr1_200121942_200122869	0.11	ENSG00000221403	.	8443	0.27
chr1_224026385_224026536	0.11	TP53BP2	tumor protein p53 binding protein, 2	7172	0.28
chr1_91481513_91481868	0.11	ZNF644	zinc finger protein 644	5324	0.35
chr1_113383632_113383813	0.11	SLC16A1	solute carrier family 16 (monocarboxylate transporter), member 1	94888	0.06
chr9_134504383_134504534	0.11	RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	3123	0.3
chr3_186518618_186518769	0.11	RFC4	replication factor C (activator 1) 4, 37kDa	3820	0.09
chr5_40674108_40674292	0.11	PTGER4	prostaglandin E receptor 4 (subtype EP4)	5400	0.23
chr3_187644954_187645105	0.11	BCL6	B-cell CLL/lymphoma 6	181514	0.03
chr7_32886085_32886236	0.11	KBTBD2	kelch repeat and BTB (POZ) domain containing 2	44605	0.14
chr6_56109453_56109604	0.11	COL21A1	collagen, type XXI, alpha 1	2707	0.4
chr5_68339437_68339588	0.11	SLC30A5	solute carrier family 30 (zinc transporter), member 5	49961	0.12
chr19_47948776_47948927	0.11	MEIS3	Meis homeobox 3	26071	0.11
chr9_15500835_15500986	0.11	PSIP1	PC4 and SFRS1 interacting protein 1	9377	0.17
chr1_32447200_32447431	0.11	KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	32115	0.13
chr19_2624596_2624817	0.11	CTC-265F19.3		7246	0.14
chr8_71132477_71132643	0.11	NCOA2	nuclear receptor coactivator 2	25050	0.23
chr20_21552286_21552437	0.11	NKX2-2	NK2 homeobox 2	57697	0.13
chr5_112215979_112216130	0.11	ZRSR1	zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1	11259	0.12
chr11_63332130_63332281	0.11	HRASLS2	HRAS-like suppressor 2	1350	0.37
chr9_92032244_92032395	0.11	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	1429	0.51
chr21_17123521_17123672	0.11	USP25	ubiquitin specific peptidase 25	21100	0.21
chr6_70525704_70525879	0.11	LMBRD1	LMBR1 domain containing 1	18788	0.25
chr11_73495057_73495208	0.11	MRPL48	mitochondrial ribosomal protein L48	3229	0.19
chr22_22081173_22081324	0.11	ENSG00000244671	.	3777	0.16
chr4_36256915_36257081	0.11	RP11-431M7.3		1142	0.53
chr4_1710080_1710231	0.11	SLBP	stem-loop binding protein	3590	0.17
chr1_32644341_32644638	0.11	TXLNA	taxilin alpha	798	0.41
chrX_1781946_1782112	0.11	ASMT	acetylserotonin O-methyltransferase	26738	0.22
chrY_1731945_1732112	0.11	ENSG00000251841	.	920762	0.0
chr12_120113093_120113244	0.11	PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	3119	0.22
chr1_192541505_192541656	0.11	RGS1	regulator of G-protein signaling 1	3277	0.26
chr1_109836886_109837045	0.11	PSRC1	proline/serine-rich coiled-coil 1	11157	0.15
chr1_25888465_25889044	0.11	LDLRAP1	low density lipoprotein receptor adaptor protein 1	18683	0.19
chr1_117352258_117352539	0.11	CD2	CD2 molecule	55309	0.12

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX3_EVX1_MEOX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.1	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.1	GO:0060510	lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	GO:0060605	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1	GO:0052167	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.1	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.3	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.1	GO:0032060	bleb assembly(GO:0032060)
0.1	GO:0071699	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.1	GO:0072577	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1	GO:0009414	response to water deprivation(GO:0009414)
0.1	GO:0051709	regulation of killing of cells of other organism(GO:0051709) positive regulation of killing of cells of other organism(GO:0051712)
0.2	GO:0007172	signal complex assembly(GO:0007172)
0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.1	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.2	GO:0006491	N-glycan processing(GO:0006491)
0.1	GO:0060539	diaphragm development(GO:0060539)
0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1	GO:0006925	inflammatory cell apoptotic process(GO:0006925)
0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.1	GO:0072600	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1	GO:0051294	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	GO:2000644	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.1	GO:0032933	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.1	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.1	GO:2000758	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.2	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.1	GO:0034086	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.1	GO:0032733	positive regulation of interleukin-10 production(GO:0032733)
0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	GO:0001705	ectoderm formation(GO:0001705)
0.1	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	GO:0002507	tolerance induction(GO:0002507)
0.0	GO:1903332	regulation of protein folding(GO:1903332)
0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.1	GO:0015781	pyrimidine nucleotide-sugar transport(GO:0015781)
0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.1	GO:0015671	oxygen transport(GO:0015671)
0.1	GO:1904376	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.1	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.1	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	GO:0032455	nerve growth factor processing(GO:0032455)
0.1	GO:0031648	protein destabilization(GO:0031648)
0.0	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0	GO:0071569	protein ufmylation(GO:0071569)
0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	GO:0017085	response to insecticide(GO:0017085)
0.1	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.5	GO:0030521	androgen receptor signaling pathway(GO:0030521)
0.0	GO:0032212	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	GO:0000103	sulfate assimilation(GO:0000103)
0.0	GO:2001234	negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0	GO:0006089	lactate metabolic process(GO:0006089)
0.1	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	GO:0072131	kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.2	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0043159	acrosomal matrix(GO:0043159)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.2	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.0	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.0	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.2	GO:0016235	aggresome(GO:0016235)
0.0	0.0	GO:0070820	tertiary granule(GO:0070820)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.0	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.2	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.0	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.4	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.0	0.0	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.0	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.0	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.3	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.0	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.0	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.0	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.1	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.1	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.0	GO:0004339	glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.0	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.0	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.0	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.3	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.3	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.3	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.2	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.1	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.1	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.1	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.1	REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	Genes involved in Signaling by TGF-beta Receptor Complex
0.0	0.1	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.0	0.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling