CREMA results: E2F2

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Transcription factors associated with E2F2_E2F5

Gene Symbol	Gene ID	Gene Info
E2F2 Ensembl NCBI GeneCards UniProt	ENSG00000007968.6	E2F transcription factor 2
E2F5 Ensembl NCBI GeneCards UniProt	ENSG00000133740.6	E2F transcription factor 5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr1_23856635_23856974	E2F2	908	0.568191	0.69	3.8e-02	Click!
chr1_23857278_23857429	E2F2	359	0.864837	0.74	2.4e-02	Click!
chr1_23857552_23857703	E2F2	85	0.969441	0.72	3.0e-02	Click!
chr1_23866295_23866462	E2F2	8666	0.176019	0.70	3.5e-02	Click!
chr1_23866536_23866738	E2F2	8925	0.175245	0.88	1.9e-03	Click!
chr8_86101250_86101401	E2F5	1405	0.323320	0.18	6.4e-01	Click!
chr8_86102063_86102214	E2F5	2218	0.218893	0.29	4.5e-01	Click!
chr8_86104958_86105109	E2F5	5113	0.145131	0.13	7.3e-01	Click!
chr8_86113087_86113275	E2F5	5217	0.141711	-0.57	1.1e-01	Click!

Showing 1 to 9 of 9 entries

Activity of the E2F2_E2F5 motif across conditions

Conditions sorted by the z-value of the E2F2_E2F5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_16474453_16474697	0.78	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	1811	0.29
chr1_12201058_12201219	0.69	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	15182	0.15
chr1_205290600_205290751	0.66	NUAK2	NUAK family, SNF1-like kinase, 2	208	0.93
chr4_40057808_40058129	0.66	N4BP2	NEDD4 binding protein 2	478	0.8
chr17_58678203_58678354	0.63	PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	734	0.66
chr4_1685292_1685462	0.61	ENSG00000207009	.	121	0.76
chr19_37287796_37287970	0.61	CTD-2162K18.5		537	0.7
chr3_153839356_153839507	0.60	ARHGEF26	Rho guanine nucleotide exchange factor (GEF) 26	202	0.64
chr21_34914620_34914771	0.60	GART	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	26	0.74
chr2_175350906_175351070	0.57	GPR155	G protein-coupled receptor 155	777	0.66

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F2_E2F5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.6	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
0.1	0.5	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.1	0.5	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.5	GO:0035329	hippo signaling(GO:0035329)
0.1	0.4	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.1	0.4	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.1	0.4	GO:0006089	lactate metabolic process(GO:0006089)
0.1	0.4	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.1	0.4	GO:0071480	cellular response to gamma radiation(GO:0071480)

Showing 1 to 10 of 143 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0008287	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.7	GO:0000922	spindle pole(GO:0000922)
0.0	0.7	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.0	0.5	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.1	0.4	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.4	GO:0036064	ciliary basal body(GO:0036064)
0.0	0.3	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.3	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	0.3	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.3	GO:0005640	nuclear outer membrane(GO:0005640)

Showing 1 to 10 of 39 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.1	0.6	GO:0045499	chemorepellent activity(GO:0045499)
0.2	0.5	GO:0030215	semaphorin receptor binding(GO:0030215)
0.2	0.5	GO:0051734	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.1	0.5	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.5	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.5	GO:0015036	disulfide oxidoreductase activity(GO:0015036)
0.0	0.5	GO:0003697	single-stranded DNA binding(GO:0003697)
0.1	0.4	GO:0016882	cyclo-ligase activity(GO:0016882)
0.1	0.4	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)

Showing 1 to 10 of 99 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.7	PID EPHB FWD PATHWAY	EPHB forward signaling
0.7	PID P53 REGULATION PATHWAY	p53 pathway
0.6	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.5	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.5	PID BMP PATHWAY	BMP receptor signaling
0.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.4	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.4	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway

Showing 1 to 10 of 19 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.5	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.5	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.5	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.5	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.5	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.5	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.5	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.4	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.4	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation

Showing 1 to 10 of 32 entries

Results for E2F2_E2F5

Z-value: 1.74

Motif logo

Transcription factors associated with E2F2_E2F5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the E2F2_E2F5 motif across conditions

Conditions sorted by the z-value of the E2F2_E2F5 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F2_E2F5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: