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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for E2F2_E2F5

Z-value: 1.74

Motif logo

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Transcription factors associated with E2F2_E2F5

Gene Symbol Gene ID Gene Info
E2F2
ENSG00000007968.6 E2F transcription factor 2
E2F5
ENSG00000133740.6 E2F transcription factor 5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr1_23866536_23866738E2F289250.1752450.881.9e-03Click!
chr1_23857278_23857429E2F23590.8648370.742.4e-02Click!
chr1_23857552_23857703E2F2850.9694410.723.0e-02Click!
chr1_23866295_23866462E2F286660.1760190.703.5e-02Click!
chr1_23856635_23856974E2F29080.5681910.693.8e-02Click!
chr8_86113087_86113275E2F552170.141711-0.571.1e-01Click!
chr8_86102063_86102214E2F522180.2188930.294.5e-01Click!
chr8_86101250_86101401E2F514050.3233200.186.4e-01Click!
chr8_86104958_86105109E2F551130.1451310.137.3e-01Click!

Activity of the E2F2_E2F5 motif across conditions

Conditions sorted by the z-value of the E2F2_E2F5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr19_16474453_16474697 0.78 EPS15L1
 epidermal growth factor receptor pathway substrate 15-like 1
 1811
 0.29
chr1_12201058_12201219 0.69 TNFRSF8
 tumor necrosis factor receptor superfamily, member 8
 15182
 0.15
chr1_205290600_205290751 0.66 NUAK2
 NUAK family, SNF1-like kinase, 2
 208
 0.93
chr4_40057808_40058129 0.66 N4BP2
 NEDD4 binding protein 2
 478
 0.8
chr17_58678203_58678354 0.63 PPM1D
 protein phosphatase, Mg2+/Mn2+ dependent, 1D
 734
 0.66
chr4_1685292_1685462 0.61 ENSG00000207009
 .
 121
 0.76
chr19_37287796_37287970 0.61 CTD-2162K18.5
537
 0.7
chr3_153839356_153839507 0.60 ARHGEF26
 Rho guanine nucleotide exchange factor (GEF) 26
 202
 0.64
chr21_34914620_34914771 0.60 GART
 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
 26
 0.74
chr2_175350906_175351070 0.57 GPR155
 G protein-coupled receptor 155
 777
 0.66
chr5_69321527_69321686 0.57 SERF1B
 small EDRK-rich factor 1B (centromeric)
 245
 0.94
chr15_74907592_74907743 0.55 CTD-3154N5.1
270
 0.55
chr4_108911771_108911922 0.55 HADH
 hydroxyacyl-CoA dehydrogenase
 788
 0.64
chr13_50070457_50070608 0.55 PHF11
 PHD finger protein 11
 1
 0.98
chrX_11683937_11684088 0.52 ARHGAP6
 Rho GTPase activating protein 6
 191
 0.97
chr5_107006410_107006592 0.52 EFNA5
 ephrin-A5
 95
 0.98
chr1_235247512_235247663 0.52 ENSG00000207181
 .
 43665
 0.13
chr7_100034344_100034495 0.51 PPP1R35
 protein phosphatase 1, regulatory subunit 35
 231
 0.69
chr15_66995452_66995652 0.51 SMAD6
 SMAD family member 6
 878
 0.68
chr10_25013084_25013502 0.50 ARHGAP21
 Rho GTPase activating protein 21
 696
 0.79
chr6_150039448_150039648 0.50 LATS1
 large tumor suppressor kinase 1
 156
 0.94
chr17_78966391_78966691 0.49 CHMP6
 charged multivesicular body protein 6
 900
 0.43
chr2_233180899_233181095 0.49 DIS3L2
 DIS3 mitotic control homolog (S. cerevisiae)-like 2
 17656
 0.17
chr7_76139277_76139433 0.49 UPK3B
 uroplakin 3B
 390
 0.81
chr11_57123702_57124132 0.48 ENSG00000266018
 .
 3279
 0.12
chr2_219575773_219575924 0.48 TTLL4
 tubulin tyrosine ligase-like family, member 4
 131
 0.94
chr14_24665331_24665657 0.48 TM9SF1
 transmembrane 9 superfamily member 1
 601
 0.42
chr9_137393142_137393331 0.48 RXRA
 retinoid X receptor, alpha
 94808
 0.07
chr11_106889622_106889773 0.47 GUCY1A2
 guanylate cyclase 1, soluble, alpha 2
 447
 0.91
chr15_47476999_47477319 0.47 SEMA6D
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
 701
 0.73
chr15_43415038_43415301 0.47 TMEM62
 transmembrane protein 62
 308
 0.89
chr15_71184789_71184970 0.46 LRRC49
 leucine rich repeat containing 49
 86
 0.56
chr2_242625596_242625805 0.46 DTYMK
 deoxythymidylate kinase (thymidylate kinase)
 408
 0.72
chr12_21810059_21810237 0.46 LDHB
 lactate dehydrogenase B
 148
 0.96
chr2_105473259_105473410 0.46 POU3F3
 POU class 3 homeobox 3
 1365
 0.32
chr18_37379955_37380106 0.45 ENSG00000212354
 .
 121444
 0.06
chr2_175351124_175351275 0.45 GPR155
 G protein-coupled receptor 155
 566
 0.77
chr12_122984418_122984836 0.45 ZCCHC8
 zinc finger, CCHC domain containing 8
 168
 0.94
chr11_67165283_67165521 0.44 ENSG00000253024
 .
 2620
 0.1
chr14_95234863_95235014 0.44 GSC
 goosecoid homeobox
 1624
 0.5
chr8_98289888_98290039 0.43 TSPYL5
 TSPY-like 5
 213
 0.96
chr7_143599335_143599486 0.43 FAM115A
 family with sequence similarity 115, member A
 119
 0.96
chr2_172380242_172380480 0.42 CYBRD1
 cytochrome b reductase 1
 772
 0.73
chr2_148394331_148394482 0.41 ENSG00000253083
 .
 76717
 0.11
chr5_41870001_41870238 0.41 ENSG00000248668
 .
 13
 0.91
chr19_18530764_18530945 0.41 SSBP4
 single stranded DNA binding protein 4
 59
 0.94
chr2_91997601_91997765 0.40 IGKV1OR-1
 immunoglobulin kappa variable 1/OR-1 (pseudogene)
 8114
 0.25
chr2_27631816_27631967 0.40 PPM1G
 protein phosphatase, Mg2+/Mn2+ dependent, 1G
 558
 0.58
chr4_151937156_151937307 0.40 LRBA
 LPS-responsive vesicle trafficking, beach and anchor containing
 352
 0.89
chr19_50353966_50354117 0.39 PTOV1
 prostate tumor overexpressed 1
 30
 0.75
chr19_30432531_30432893 0.39 URI1
 URI1, prefoldin-like chaperone
 446
 0.9
chr8_94752567_94752718 0.39 RBM12B-AS1
 RBM12B antisense RNA 1
 293
 0.43
chr7_90226220_90226410 0.38 AC002456.2
352
 0.61
chr3_50377830_50377981 0.38 RASSF1
 Ras association (RalGDS/AF-6) domain family member 1
 367
 0.53
chr5_150473994_150474160 0.38 TNIP1
 TNFAIP3 interacting protein 1
 939
 0.58
chr4_55096263_55096414 0.37 PDGFRA
 platelet-derived growth factor receptor, alpha polypeptide
 151
 0.97
chr2_221969094_221969245 0.37 EPHA4
 EPH receptor A4
 398111
 0.01
chr7_99716711_99716862 0.37 TAF6
 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
 141
 0.74
chr11_65687460_65687611 0.37 DRAP1
 DR1-associated protein 1 (negative cofactor 2 alpha)
 340
 0.67
chr3_72127692_72127843 0.37 ENSG00000212070
 .
 183812
 0.03
chr13_46755573_46755724 0.37 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
 811
 0.58
chr10_70320973_70321232 0.36 TET1
 tet methylcytosine dioxygenase 1
 689
 0.69
chr7_27204759_27204916 0.36 HOXA9
 homeobox A9
 308
 0.69
chr3_136824240_136824391 0.36 IL20RB-AS1
 IL20RB antisense RNA 1
 123277
 0.06
chr8_27695395_27695562 0.36 PBK
 PDZ binding kinase
 121
 0.96
chr12_49374639_49374845 0.35 WNT1
 wingless-type MMTV integration site family, member 1
 2344
 0.11
chr18_11850127_11850406 0.35 CHMP1B
 charged multivesicular body protein 1B
 1129
 0.36
chr5_271481_271632 0.35 CTD-2083E4.6
75
 0.65
chr8_22551640_22551890 0.35 EGR3
 early growth response 3
 950
 0.44
chr1_31769225_31769468 0.35 SNRNP40
 small nuclear ribonucleoprotein 40kDa (U5)
 271
 0.69
chr11_58874195_58874346 0.35 FAM111B
 family with sequence similarity 111, member B
 388
 0.85
chr12_4381658_4381881 0.35 CCND2
 cyclin D2
 1169
 0.41
chr19_52773021_52773172 0.34 ZNF766
 zinc finger protein 766
 250
 0.85
chr10_62703240_62703501 0.34 RHOBTB1
 Rho-related BTB domain containing 1
 635
 0.8
chr17_35292034_35292185 0.33 RP11-445F12.1
1812
 0.23
chr10_11059547_11059708 0.33 CELF2
 CUGBP, Elav-like family member 2
 266
 0.92
chr11_62541978_62542240 0.33 TAF6L
 TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
 2598
 0.08
chr3_55522055_55522206 0.33 WNT5A-AS1
 WNT5A antisense RNA 1
 403
 0.72
chr6_52929743_52930148 0.33 FBXO9
 F-box protein 9
 149
 0.93
chrX_132092122_132092387 0.33 HS6ST2
 heparan sulfate 6-O-sulfotransferase 2
 910
 0.71
chr6_106328518_106328778 0.33 ENSG00000200198
 .
 23600
 0.27
chrX_55515914_55516065 0.32 USP51
 ubiquitin specific peptidase 51
 354
 0.89
chrX_73164517_73164668 0.32 RP13-216E22.5
24728
 0.23
chr17_7900691_7900842 0.32 GUCY2D
 guanylate cyclase 2D, membrane (retina-specific)
 5146
 0.12
chr3_169720111_169720354 0.32 SEC62-AS1
 SEC62 antisense RNA 1
 16729
 0.13
chr19_14318195_14318346 0.32 LPHN1
 latrophilin 1
 1271
 0.38
chr11_44748743_44748894 0.32 TSPAN18
 tetraspanin 18
 94
 0.98
chr19_40315056_40315207 0.32 DYRK1B
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
 7376
 0.16
chr6_3229015_3229236 0.31 TUBB2B
 tubulin, beta 2B class IIb
 1156
 0.44
chr6_8102779_8102930 0.31 EEF1E1
 eukaryotic translation elongation factor 1 epsilon 1
 43
 0.98
chr19_16946806_16946957 0.31 SIN3B
 SIN3 transcription regulator family member B
 5882
 0.14
chr11_118272145_118272296 0.31 ATP5L
 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
 127
 0.77
chr22_39993919_39994070 0.31 CACNA1I
 calcium channel, voltage-dependent, T type, alpha 1I subunit
 27236
 0.17
chr11_58673004_58673248 0.31 AP001652.1
 Uncharacterized protein; cDNA FLJ60524
 229
 0.91
chr20_2082194_2082410 0.31 STK35
 serine/threonine kinase 35
 45
 0.98
chr2_232573942_232574135 0.31 PTMA
 prothymosin, alpha
 453
 0.78
chr1_243431690_243431841 0.31 SDCCAG8
 serologically defined colon cancer antigen 8
 12393
 0.18
chr12_57481350_57481630 0.30 NAB2
 NGFI-A binding protein 2 (EGR1 binding protein 2)
 1187
 0.3
chr10_11652685_11653021 0.30 RP11-138I18.1
451
 0.7
chr1_117664616_117664767 0.30 TRIM45
 tripartite motif containing 45
 277
 0.9
chr2_19558652_19558898 0.30 OSR1
 odd-skipped related transciption factor 1
 361
 0.91
chr9_23831341_23831632 0.30 ELAVL2
 ELAV like neuron-specific RNA binding protein 2
 5151
 0.37
chr3_183498240_183498391 0.30 YEATS2
 YEATS domain containing 2
 4536
 0.17
chr10_131935434_131935764 0.30 GLRX3
 glutaredoxin 3
 936
 0.73
chr5_43064735_43064935 0.30 CTD-2201E18.3
2686
 0.21
chr14_97879326_97879526 0.30 ENSG00000240730
 .
 117084
 0.07
chr17_25782767_25783007 0.29 KSR1
 kinase suppressor of ras 1
 783
 0.65
chr16_70834690_70834841 0.29 VAC14
 Vac14 homolog (S. cerevisiae)
 299
 0.89
chr7_54732618_54732769 0.29 ENSG00000200471
 .
 43975
 0.16
chr3_4509025_4509208 0.29 SUMF1
 sulfatase modifying factor 1
 151
 0.96
chr15_93180047_93180198 0.29 FAM174B
 family with sequence similarity 174, member B
 2352
 0.36
chr4_74486561_74486712 0.29 RASSF6
 Ras association (RalGDS/AF-6) domain family member 6
 288
 0.94
chr4_174256659_174256871 0.29 HMGB2
 high mobility group box 2
 489
 0.74
chr14_64400542_64400693 0.29 SYNE2
 spectrin repeat containing, nuclear envelope 2
 24801
 0.22
chr16_70729532_70729806 0.29 VAC14
 Vac14 homolog (S. cerevisiae)
 173
 0.93
chr2_105275814_105276048 0.29 ENSG00000207249
 .
 73761
 0.1
chr4_39045763_39045975 0.29 KLHL5
 kelch-like family member 5
 790
 0.66
chr21_28216861_28217012 0.28 ADAMTS1
 ADAM metallopeptidase with thrombospondin type 1 motif, 1
 792
 0.73
chr2_26681881_26682032 0.28 DRC1
 dynein regulatory complex subunit 1 homolog (Chlamydomonas)
 10789
 0.2
chr12_12877982_12878133 0.28 APOLD1
 apolipoprotein L domain containing 1
 808
 0.43
chr10_108758695_108758846 0.28 ENSG00000200626
 .
 28991
 0.26
chr2_113190370_113190521 0.28 RGPD8
 RANBP2-like and GRIP domain containing 8
 651
 0.76
chrX_39865999_39866213 0.28 BCOR
 BCL6 corepressor
 56084
 0.17
chr9_104500822_104500973 0.27 GRIN3A
 glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
 35
 0.99
chr15_45405087_45405238 0.27 DUOX2
 dual oxidase 2
 1197
 0.25
chr3_32822211_32822366 0.27 TRIM71
 tripartite motif containing 71, E3 ubiquitin protein ligase
 37222
 0.15
chr1_27682961_27683240 0.27 MAP3K6
 mitogen-activated protein kinase kinase kinase 6
 138
 0.93
chr14_99009042_99009193 0.27 C14orf177
 chromosome 14 open reading frame 177
 168833
 0.04
chr9_84305434_84305645 0.27 TLE1
 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
 1319
 0.53
chr12_31811913_31812064 0.27 METTL20
 methyltransferase like 20
 133
 0.96
chr11_17374066_17374428 0.27 NCR3LG1
 natural killer cell cytotoxicity receptor 3 ligand 1
 974
 0.52
chr3_14219692_14219843 0.27 LSM3
 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
 91
 0.77
chr10_99051887_99052112 0.26 ARHGAP19-SLIT1
 ARHGAP19-SLIT1 readthrough (NMD candidate)
 385
 0.46
chr2_47403393_47403544 0.26 CALM2
 calmodulin 2 (phosphorylase kinase, delta)
 182
 0.96
chr1_23884944_23885095 0.26 ID3
 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
 1266
 0.44
chr2_190648545_190648696 0.26 ORMDL1
 ORM1-like 1 (S. cerevisiae)
 321
 0.59
chr16_3550718_3550869 0.26 CLUAP1
 clusterin associated protein 1
 131
 0.94
chr6_142467659_142468075 0.26 VTA1
 vesicle (multivesicular body) trafficking 1
 500
 0.81
chr15_44719994_44720235 0.26 CTDSPL2
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
 102
 0.91
chr16_68563969_68564120 0.26 ZFP90
 ZFP90 zinc finger protein
 7
 0.97
chr8_25903900_25904102 0.26 EBF2
 early B-cell factor 2
 1088
 0.66
chrX_118753397_118753600 0.26 NKRF
 NFKB repressing factor
 13640
 0.15
chr5_136899668_136899823 0.26 ENSG00000221612
 .
 30602
 0.19
chr20_35724684_35724840 0.26 RBL1
 retinoblastoma-like 1 (p107)
 364
 0.9
chr4_90221268_90221504 0.26 GPRIN3
 GPRIN family member 3
 7775
 0.31
chr2_46526159_46526310 0.26 EPAS1
 endothelial PAS domain protein 1
 1693
 0.49
chr10_125846427_125846578 0.25 CHST15
 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
 5468
 0.31
chr12_94853936_94854087 0.25 CCDC41
 coiled-coil domain containing 41
 247
 0.94
chr12_58223196_58223436 0.25 CTDSP2
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
 17
 0.94
chr12_95868302_95868453 0.25 METAP2
 methionyl aminopeptidase 2
 439
 0.84
chr10_129861675_129861865 0.25 PTPRE
 protein tyrosine phosphatase, receptor type, E
 15936
 0.26
chr17_4607619_4607770 0.25 PELP1
 proline, glutamate and leucine rich protein 1
 62
 0.63
chr3_107352295_107352521 0.25 BBX
 bobby sox homolog (Drosophila)
 12275
 0.31
chr15_47476608_47476882 0.25 SEMA6D
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
 447
 0.85
chr1_35908347_35908498 0.24 KIAA0319L
 KIAA0319-like
 11886
 0.17
chr1_22432425_22432576 0.24 WNT4
 wingless-type MMTV integration site family, member 4
 23844
 0.15
chr14_52959290_52959441 0.24 TXNDC16
 thioredoxin domain containing 16
 59858
 0.12
chr2_225905663_225905934 0.24 DOCK10
 dedicator of cytokinesis 10
 1361
 0.55
chr18_61638270_61638435 0.24 SERPINB8
 serpin peptidase inhibitor, clade B (ovalbumin), member 8
 613
 0.73
chr1_198744986_198745208 0.24 ENSG00000207975
 .
 83014
 0.09
chr21_45077557_45077755 0.24 HSF2BP
 heat shock transcription factor 2 binding protein
 369
 0.84
chr20_822843_822995 0.24 FAM110A
 family with sequence similarity 110, member A
 2366
 0.35
chr11_10329277_10329428 0.24 ADM
 adrenomedullin
 2428
 0.23
chr19_57351053_57351204 0.24 PEG3
 paternally expressed 3
 936
 0.39
chr6_42858705_42858888 0.24 C6orf226
 chromosome 6 open reading frame 226
 242
 0.88
chr2_113590430_113590581 0.24 IL1B
 interleukin 1, beta
 3506
 0.21
chr13_50707168_50707390 0.24 DLEU1
 deleted in lymphocytic leukemia 1 (non-protein coding)
 50972
 0.13
chr3_141030206_141030479 0.24 ZBTB38
 zinc finger and BTB domain containing 38
 12713
 0.22
chr15_53080371_53080530 0.24 ONECUT1
 one cut homeobox 1
 1759
 0.48
chr1_54665245_54665442 0.23 CYB5RL
 cytochrome b5 reductase-like
 342
 0.59
chr16_84401523_84401674 0.23 ATP2C2
 ATPase, Ca++ transporting, type 2C, member 2
 535
 0.79
chr10_81850627_81850778 0.23 TMEM254
 transmembrane protein 254
 9223
 0.18
chr8_143859283_143859453 0.23 LYNX1
 Ly6/neurotoxin 1
 142
 0.91
chr1_26362139_26362300 0.23 SLC30A2
 solute carrier family 30 (zinc transporter), member 2
 10385
 0.1
chr22_50634186_50634337 0.23 TRABD
 TraB domain containing
 2818
 0.11
chr15_89949515_89949757 0.23 ENSG00000207819
 .
 38388
 0.14
chr21_45138541_45138692 0.23 PDXK
 pyridoxal (pyridoxine, vitamin B6) kinase
 359
 0.88
chr14_24610403_24610554 0.23 EMC9
 ER membrane protein complex subunit 9
 301
 0.7
chr2_177502756_177502963 0.23 ENSG00000252027
 .
 26545
 0.25
chr4_1161143_1161294 0.23 RP11-20I20.4
348
 0.81
chr15_56756676_56757156 0.23 MNS1
 meiosis-specific nuclear structural 1
 419
 0.9
chr1_101701824_101702062 0.23 RP4-575N6.4
141
 0.83
chr17_74380229_74380402 0.23 PRPSAP1
 phosphoribosyl pyrophosphate synthetase-associated protein 1
 250
 0.55
chr6_26088017_26088347 0.23 HFE
 hemochromatosis
 515
 0.56
chr8_81806183_81806334 0.23 ZNF704
 zinc finger protein 704
 19242
 0.26
chr19_50935443_50935594 0.22 MYBPC2
 myosin binding protein C, fast type
 642
 0.51
chr11_13300608_13301500 0.22 ARNTL
 aryl hydrocarbon receptor nuclear translocator-like
 1622
 0.51
chrX_129090519_129090731 0.22 RP4-537K23.4
879
 0.61
chr7_27162728_27162879 0.22 HOXA-AS2
 HOXA cluster antisense RNA 2
 16
 0.93
chr1_149982777_149982991 0.22 OTUD7B
 OTU domain containing 7B
 259
 0.9
chr13_31735240_31735730 0.22 HSPH1
 heat shock 105kDa/110kDa protein 1
 571
 0.83
chr9_77112695_77112868 0.22 RORB
 RAR-related orphan receptor B
 500
 0.75
chr19_4519048_4519199 0.22 PLIN4
 perilipin 4
 1407
 0.24
chr19_45490552_45490703 0.22 CLPTM1
 cleft lip and palate associated transmembrane protein 1
 4899
 0.1
chr1_33190488_33190689 0.22 RP11-114B7.6
250
 0.9
chr17_46048605_46048756 0.22 CDK5RAP3
 CDK5 regulatory subunit associated protein 3
 163
 0.9
chr6_82461023_82461181 0.22 FAM46A
 family with sequence similarity 46, member A
 368
 0.88
chr16_31712181_31712332 0.22 CLUHP3
 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
 2233
 0.26
chr7_48285350_48285616 0.22 ABCA13
 ATP-binding cassette, sub-family A (ABC1), member 13
 74426
 0.12
chr3_42623874_42624044 0.22 SEC22C
 SEC22 vesicle trafficking protein homolog C (S. cerevisiae)
 140
 0.86

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F2_E2F5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.1 0.4 GO:0009189 deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.1 0.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.5 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 0.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.4 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.3 GO:0072162 mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 0.4 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.1 0.1 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 0.2 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.1 0.2 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 0.2 GO:0003079 obsolete positive regulation of natriuresis(GO:0003079)
0.1 0.4 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.1 0.5 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 0.1 GO:0042118 endothelial cell activation(GO:0042118)
0.1 0.1 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
0.1 0.2 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 0.2 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 0.2 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.1 0.2 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.2 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.2 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.2 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0097709 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.2 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 0.6 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.0 0.5 GO:0035329 hippo signaling(GO:0035329)
0.0 0.2 GO:0061384 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.3 GO:0060134 prepulse inhibition(GO:0060134)
0.0 0.2 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.2 GO:0072070 loop of Henle development(GO:0072070)
0.0 0.1 GO:0034371 chylomicron remodeling(GO:0034371)
0.0 0.1 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.0 GO:0072033 renal vesicle formation(GO:0072033)
0.0 0.1 GO:0010193 response to ozone(GO:0010193)
0.0 0.1 GO:0021778 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0 0.3 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.2 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.0 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.1 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0 0.1 GO:0090047 obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0 0.1 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.1 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.1 GO:0000492 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.1 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0 0.1 GO:0001705 ectoderm formation(GO:0001705)
0.0 0.0 GO:0051940 regulation of neurotransmitter uptake(GO:0051580) regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940)
0.0 0.1 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.4 GO:0018200 peptidyl-glutamic acid modification(GO:0018200)
0.0 0.2 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.0 GO:0032928 regulation of superoxide anion generation(GO:0032928)
0.0 0.0 GO:0052305 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308) positive regulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052555) positive regulation by symbiont of host immune response(GO:0052556)
0.0 0.0 GO:0002679 respiratory burst involved in defense response(GO:0002679)
0.0 0.1 GO:0006565 L-serine catabolic process(GO:0006565)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.1 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0045003 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.1 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.0 GO:2000192 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0 0.1 GO:2000008 regulation of protein localization to cell surface(GO:2000008)
0.0 0.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.1 GO:0060992 response to fungicide(GO:0060992)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 0.2 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.3 GO:0010039 response to iron ion(GO:0010039)
0.0 0.1 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.2 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.0 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.4 GO:0014823 response to activity(GO:0014823)
0.0 0.0 GO:0009158 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.2 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.0 GO:1901320 negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.0 0.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.1 GO:0014832 urinary bladder smooth muscle contraction(GO:0014832)
0.0 0.4 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 0.1 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.1 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.2 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.0 GO:0006188 IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0 0.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.0 GO:0055089 fatty acid homeostasis(GO:0055089)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.0 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.0 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.1 GO:0046655 folic acid metabolic process(GO:0046655)
0.0 0.0 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0045416 positive regulation of interleukin-8 biosynthetic process(GO:0045416)
0.0 0.2 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.1 GO:0007097 nuclear migration(GO:0007097)
0.0 0.1 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.1 GO:0030903 notochord development(GO:0030903)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.0 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.0 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.0 0.1 GO:0046051 GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051)
0.0 0.1 GO:1901678 iron coordination entity transport(GO:1901678)
0.0 0.1 GO:0098657 neurotransmitter uptake(GO:0001504) import into cell(GO:0098657)
0.0 0.0 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.3 GO:0002286 T cell activation involved in immune response(GO:0002286)
0.0 0.2 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.0 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.1 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.0 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.1 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.2 GO:0006862 nucleotide transport(GO:0006862)
0.0 0.1 GO:0006385 transcription elongation from RNA polymerase III promoter(GO:0006385) termination of RNA polymerase III transcription(GO:0006386)
0.0 0.0 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.0 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.1 GO:0009109 coenzyme catabolic process(GO:0009109)
0.0 0.0 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.4 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.0 0.1 GO:0048536 spleen development(GO:0048536)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.0 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.1 GO:0042023 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.3 GO:0043928 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.1 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 0.3 GO:0051318 G1 phase(GO:0051318)
0.0 0.0 GO:0010613 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0030914 STAGA complex(GO:0030914)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.2 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.8 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.1 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.7 GO:0000922 spindle pole(GO:0000922)
0.0 0.1 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.1 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.0 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.4 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.3 GO:0031526 brush border membrane(GO:0031526)
0.0 0.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.1 GO:0000805 X chromosome(GO:0000805)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.1 GO:0042627 chylomicron(GO:0042627)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 0.5 GO:0051734 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.1 0.4 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.6 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.5 GO:0016004 phospholipase activator activity(GO:0016004)
0.1 0.3 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.3 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 0.2 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 0.2 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.1 0.3 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.4 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.1 0.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.1 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.3 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.1 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.2 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.2 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.4 GO:0004835 tubulin-tyrosine ligase activity(GO:0004835)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.1 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.2 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.3 GO:0016986 obsolete transcription initiation factor activity(GO:0016986)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.1 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.1 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.1 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.0 0.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.1 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.1 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.1 GO:0001077 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.4 GO:0019201 nucleotide kinase activity(GO:0019201)
0.0 0.5 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 0.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.1 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.0 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0008159 obsolete positive transcription elongation factor activity(GO:0008159)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.0 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.1 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.2 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.0 GO:0015605 organophosphate ester transmembrane transporter activity(GO:0015605)
0.0 0.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.0 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.0 GO:0035197 siRNA binding(GO:0035197)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.0 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.0 GO:0048156 tau protein binding(GO:0048156)
0.0 0.0 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.0 GO:0034187 obsolete apolipoprotein E binding(GO:0034187)
0.0 0.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.0 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.0 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.2 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.6 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.7 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.5 PID BMP PATHWAY BMP receptor signaling
0.0 0.2 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.1 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.1 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.4 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.0 REACTOME GABA B RECEPTOR ACTIVATION Genes involved in GABA B receptor activation
0.0 0.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.1 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.3 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.1 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.2 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.1 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants