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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for E2F2_E2F5

Z-value: 1.74

Motif logo

Transcription factors associated with E2F2_E2F5

Gene Symbol	Gene ID	Gene Info
E2F2 Ensembl NCBI GeneCards UniProt	ENSG00000007968.6	E2F2
E2F5 Ensembl NCBI GeneCards UniProt	ENSG00000133740.6	E2F5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
E2F2	chr1_23866536_23866738	8925	0.175245	0.88	1.9e-03	Click!
E2F2	chr1_23857278_23857429	359	0.864837	0.74	2.4e-02	Click!
E2F2	chr1_23857552_23857703	85	0.969441	0.72	3.0e-02	Click!
E2F2	chr1_23866295_23866462	8666	0.176019	0.70	3.5e-02	Click!
E2F2	chr1_23856635_23856974	908	0.568191	0.69	3.8e-02	Click!
E2F5	chr8_86113087_86113275	5217	0.141711	-0.57	1.1e-01	Click!
E2F5	chr8_86102063_86102214	2218	0.218893	0.29	4.5e-01	Click!
E2F5	chr8_86101250_86101401	1405	0.323320	0.18	6.4e-01	Click!
E2F5	chr8_86104958_86105109	5113	0.145131	0.13	7.3e-01	Click!

Activity of the E2F2_E2F5 motif across conditions

Conditions sorted by the z-value of the E2F2_E2F5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_16474453_16474697	0.78	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	1811	0.29
chr1_12201058_12201219	0.69	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	15182	0.15
chr1_205290600_205290751	0.66	NUAK2	NUAK family, SNF1-like kinase, 2	208	0.93
chr4_40057808_40058129	0.66	N4BP2	NEDD4 binding protein 2	478	0.8
chr17_58678203_58678354	0.63	PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	734	0.66
chr4_1685292_1685462	0.61	ENSG00000207009	.	121	0.76
chr19_37287796_37287970	0.61	CTD-2162K18.5		537	0.7
chr3_153839356_153839507	0.60	ARHGEF26	Rho guanine nucleotide exchange factor (GEF) 26	202	0.64
chr21_34914620_34914771	0.60	GART	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	26	0.74
chr2_175350906_175351070	0.57	GPR155	G protein-coupled receptor 155	777	0.66
chr5_69321527_69321686	0.57	SERF1B	small EDRK-rich factor 1B (centromeric)	245	0.94
chr15_74907592_74907743	0.55	CTD-3154N5.1		270	0.55
chr4_108911771_108911922	0.55	HADH	hydroxyacyl-CoA dehydrogenase	788	0.64
chr13_50070457_50070608	0.55	PHF11	PHD finger protein 11	1	0.98
chrX_11683937_11684088	0.52	ARHGAP6	Rho GTPase activating protein 6	191	0.97
chr5_107006410_107006592	0.52	EFNA5	ephrin-A5	95	0.98
chr1_235247512_235247663	0.52	ENSG00000207181	.	43665	0.13
chr7_100034344_100034495	0.51	PPP1R35	protein phosphatase 1, regulatory subunit 35	231	0.69
chr15_66995452_66995652	0.51	SMAD6	SMAD family member 6	878	0.68
chr10_25013084_25013502	0.50	ARHGAP21	Rho GTPase activating protein 21	696	0.79
chr6_150039448_150039648	0.50	LATS1	large tumor suppressor kinase 1	156	0.94
chr17_78966391_78966691	0.49	CHMP6	charged multivesicular body protein 6	900	0.43
chr2_233180899_233181095	0.49	DIS3L2	DIS3 mitotic control homolog (S. cerevisiae)-like 2	17656	0.17
chr7_76139277_76139433	0.49	UPK3B	uroplakin 3B	390	0.81
chr11_57123702_57124132	0.48	ENSG00000266018	.	3279	0.12
chr2_219575773_219575924	0.48	TTLL4	tubulin tyrosine ligase-like family, member 4	131	0.94
chr14_24665331_24665657	0.48	TM9SF1	transmembrane 9 superfamily member 1	601	0.42
chr9_137393142_137393331	0.48	RXRA	retinoid X receptor, alpha	94808	0.07
chr11_106889622_106889773	0.47	GUCY1A2	guanylate cyclase 1, soluble, alpha 2	447	0.91
chr15_47476999_47477319	0.47	SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	701	0.73
chr15_43415038_43415301	0.47	TMEM62	transmembrane protein 62	308	0.89
chr15_71184789_71184970	0.46	LRRC49	leucine rich repeat containing 49	86	0.56
chr2_242625596_242625805	0.46	DTYMK	deoxythymidylate kinase (thymidylate kinase)	408	0.72
chr12_21810059_21810237	0.46	LDHB	lactate dehydrogenase B	148	0.96
chr2_105473259_105473410	0.46	POU3F3	POU class 3 homeobox 3	1365	0.32
chr18_37379955_37380106	0.45	ENSG00000212354	.	121444	0.06
chr2_175351124_175351275	0.45	GPR155	G protein-coupled receptor 155	566	0.77
chr12_122984418_122984836	0.45	ZCCHC8	zinc finger, CCHC domain containing 8	168	0.94
chr11_67165283_67165521	0.44	ENSG00000253024	.	2620	0.1
chr14_95234863_95235014	0.44	GSC	goosecoid homeobox	1624	0.5
chr8_98289888_98290039	0.43	TSPYL5	TSPY-like 5	213	0.96
chr7_143599335_143599486	0.43	FAM115A	family with sequence similarity 115, member A	119	0.96
chr2_172380242_172380480	0.42	CYBRD1	cytochrome b reductase 1	772	0.73
chr2_148394331_148394482	0.41	ENSG00000253083	.	76717	0.11
chr5_41870001_41870238	0.41	ENSG00000248668	.	13	0.91
chr19_18530764_18530945	0.41	SSBP4	single stranded DNA binding protein 4	59	0.94
chr2_91997601_91997765	0.40	IGKV1OR-1	immunoglobulin kappa variable 1/OR-1 (pseudogene)	8114	0.25
chr2_27631816_27631967	0.40	PPM1G	protein phosphatase, Mg2+/Mn2+ dependent, 1G	558	0.58
chr4_151937156_151937307	0.40	LRBA	LPS-responsive vesicle trafficking, beach and anchor containing	352	0.89
chr19_50353966_50354117	0.39	PTOV1	prostate tumor overexpressed 1	30	0.75
chr19_30432531_30432893	0.39	URI1	URI1, prefoldin-like chaperone	446	0.9
chr8_94752567_94752718	0.39	RBM12B-AS1	RBM12B antisense RNA 1	293	0.43
chr7_90226220_90226410	0.38	AC002456.2		352	0.61
chr3_50377830_50377981	0.38	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	367	0.53
chr5_150473994_150474160	0.38	TNIP1	TNFAIP3 interacting protein 1	939	0.58
chr4_55096263_55096414	0.37	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	151	0.97
chr2_221969094_221969245	0.37	EPHA4	EPH receptor A4	398111	0.01
chr7_99716711_99716862	0.37	TAF6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	141	0.74
chr11_65687460_65687611	0.37	DRAP1	DR1-associated protein 1 (negative cofactor 2 alpha)	340	0.67
chr3_72127692_72127843	0.37	ENSG00000212070	.	183812	0.03
chr13_46755573_46755724	0.37	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	811	0.58
chr10_70320973_70321232	0.36	TET1	tet methylcytosine dioxygenase 1	689	0.69
chr7_27204759_27204916	0.36	HOXA9	homeobox A9	308	0.69
chr3_136824240_136824391	0.36	IL20RB-AS1	IL20RB antisense RNA 1	123277	0.06
chr8_27695395_27695562	0.36	PBK	PDZ binding kinase	121	0.96
chr12_49374639_49374845	0.35	WNT1	wingless-type MMTV integration site family, member 1	2344	0.11
chr18_11850127_11850406	0.35	CHMP1B	charged multivesicular body protein 1B	1129	0.36
chr5_271481_271632	0.35	CTD-2083E4.6		75	0.65
chr8_22551640_22551890	0.35	EGR3	early growth response 3	950	0.44
chr1_31769225_31769468	0.35	SNRNP40	small nuclear ribonucleoprotein 40kDa (U5)	271	0.69
chr11_58874195_58874346	0.35	FAM111B	family with sequence similarity 111, member B	388	0.85
chr12_4381658_4381881	0.35	CCND2	cyclin D2	1169	0.41
chr19_52773021_52773172	0.34	ZNF766	zinc finger protein 766	250	0.85
chr10_62703240_62703501	0.34	RHOBTB1	Rho-related BTB domain containing 1	635	0.8
chr17_35292034_35292185	0.33	RP11-445F12.1		1812	0.23
chr10_11059547_11059708	0.33	CELF2	CUGBP, Elav-like family member 2	266	0.92
chr11_62541978_62542240	0.33	TAF6L	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	2598	0.08
chr3_55522055_55522206	0.33	WNT5A-AS1	WNT5A antisense RNA 1	403	0.72
chr6_52929743_52930148	0.33	FBXO9	F-box protein 9	149	0.93
chrX_132092122_132092387	0.33	HS6ST2	heparan sulfate 6-O-sulfotransferase 2	910	0.71
chr6_106328518_106328778	0.33	ENSG00000200198	.	23600	0.27
chrX_55515914_55516065	0.32	USP51	ubiquitin specific peptidase 51	354	0.89
chrX_73164517_73164668	0.32	RP13-216E22.5		24728	0.23
chr17_7900691_7900842	0.32	GUCY2D	guanylate cyclase 2D, membrane (retina-specific)	5146	0.12
chr3_169720111_169720354	0.32	SEC62-AS1	SEC62 antisense RNA 1	16729	0.13
chr19_14318195_14318346	0.32	LPHN1	latrophilin 1	1271	0.38
chr11_44748743_44748894	0.32	TSPAN18	tetraspanin 18	94	0.98
chr19_40315056_40315207	0.32	DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	7376	0.16
chr6_3229015_3229236	0.31	TUBB2B	tubulin, beta 2B class IIb	1156	0.44
chr6_8102779_8102930	0.31	EEF1E1	eukaryotic translation elongation factor 1 epsilon 1	43	0.98
chr19_16946806_16946957	0.31	SIN3B	SIN3 transcription regulator family member B	5882	0.14
chr11_118272145_118272296	0.31	ATP5L	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G	127	0.77
chr22_39993919_39994070	0.31	CACNA1I	calcium channel, voltage-dependent, T type, alpha 1I subunit	27236	0.17
chr11_58673004_58673248	0.31	AP001652.1	Uncharacterized protein; cDNA FLJ60524	229	0.91
chr20_2082194_2082410	0.31	STK35	serine/threonine kinase 35	45	0.98
chr2_232573942_232574135	0.31	PTMA	prothymosin, alpha	453	0.78
chr1_243431690_243431841	0.31	SDCCAG8	serologically defined colon cancer antigen 8	12393	0.18
chr12_57481350_57481630	0.30	NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)	1187	0.3
chr10_11652685_11653021	0.30	RP11-138I18.1		451	0.7
chr1_117664616_117664767	0.30	TRIM45	tripartite motif containing 45	277	0.9
chr2_19558652_19558898	0.30	OSR1	odd-skipped related transciption factor 1	361	0.91
chr9_23831341_23831632	0.30	ELAVL2	ELAV like neuron-specific RNA binding protein 2	5151	0.37
chr3_183498240_183498391	0.30	YEATS2	YEATS domain containing 2	4536	0.17
chr10_131935434_131935764	0.30	GLRX3	glutaredoxin 3	936	0.73
chr5_43064735_43064935	0.30	CTD-2201E18.3		2686	0.21
chr14_97879326_97879526	0.30	ENSG00000240730	.	117084	0.07
chr17_25782767_25783007	0.29	KSR1	kinase suppressor of ras 1	783	0.65
chr16_70834690_70834841	0.29	VAC14	Vac14 homolog (S. cerevisiae)	299	0.89
chr7_54732618_54732769	0.29	ENSG00000200471	.	43975	0.16
chr3_4509025_4509208	0.29	SUMF1	sulfatase modifying factor 1	151	0.96
chr15_93180047_93180198	0.29	FAM174B	family with sequence similarity 174, member B	2352	0.36
chr4_74486561_74486712	0.29	RASSF6	Ras association (RalGDS/AF-6) domain family member 6	288	0.94
chr4_174256659_174256871	0.29	HMGB2	high mobility group box 2	489	0.74
chr14_64400542_64400693	0.29	SYNE2	spectrin repeat containing, nuclear envelope 2	24801	0.22
chr16_70729532_70729806	0.29	VAC14	Vac14 homolog (S. cerevisiae)	173	0.93
chr2_105275814_105276048	0.29	ENSG00000207249	.	73761	0.1
chr4_39045763_39045975	0.29	KLHL5	kelch-like family member 5	790	0.66
chr21_28216861_28217012	0.28	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	792	0.73
chr2_26681881_26682032	0.28	DRC1	dynein regulatory complex subunit 1 homolog (Chlamydomonas)	10789	0.2
chr12_12877982_12878133	0.28	APOLD1	apolipoprotein L domain containing 1	808	0.43
chr10_108758695_108758846	0.28	ENSG00000200626	.	28991	0.26
chr2_113190370_113190521	0.28	RGPD8	RANBP2-like and GRIP domain containing 8	651	0.76
chrX_39865999_39866213	0.28	BCOR	BCL6 corepressor	56084	0.17
chr9_104500822_104500973	0.27	GRIN3A	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	35	0.99
chr15_45405087_45405238	0.27	DUOX2	dual oxidase 2	1197	0.25
chr3_32822211_32822366	0.27	TRIM71	tripartite motif containing 71, E3 ubiquitin protein ligase	37222	0.15
chr1_27682961_27683240	0.27	MAP3K6	mitogen-activated protein kinase kinase kinase 6	138	0.93
chr14_99009042_99009193	0.27	C14orf177	chromosome 14 open reading frame 177	168833	0.04
chr9_84305434_84305645	0.27	TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	1319	0.53
chr12_31811913_31812064	0.27	METTL20	methyltransferase like 20	133	0.96
chr11_17374066_17374428	0.27	NCR3LG1	natural killer cell cytotoxicity receptor 3 ligand 1	974	0.52
chr3_14219692_14219843	0.27	LSM3	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	91	0.77
chr10_99051887_99052112	0.26	ARHGAP19-SLIT1	ARHGAP19-SLIT1 readthrough (NMD candidate)	385	0.46
chr2_47403393_47403544	0.26	CALM2	calmodulin 2 (phosphorylase kinase, delta)	182	0.96
chr1_23884944_23885095	0.26	ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	1266	0.44
chr2_190648545_190648696	0.26	ORMDL1	ORM1-like 1 (S. cerevisiae)	321	0.59
chr16_3550718_3550869	0.26	CLUAP1	clusterin associated protein 1	131	0.94
chr6_142467659_142468075	0.26	VTA1	vesicle (multivesicular body) trafficking 1	500	0.81
chr15_44719994_44720235	0.26	CTDSPL2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2	102	0.91
chr16_68563969_68564120	0.26	ZFP90	ZFP90 zinc finger protein	7	0.97
chr8_25903900_25904102	0.26	EBF2	early B-cell factor 2	1088	0.66
chrX_118753397_118753600	0.26	NKRF	NFKB repressing factor	13640	0.15
chr5_136899668_136899823	0.26	ENSG00000221612	.	30602	0.19
chr20_35724684_35724840	0.26	RBL1	retinoblastoma-like 1 (p107)	364	0.9
chr4_90221268_90221504	0.26	GPRIN3	GPRIN family member 3	7775	0.31
chr2_46526159_46526310	0.26	EPAS1	endothelial PAS domain protein 1	1693	0.49
chr10_125846427_125846578	0.25	CHST15	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	5468	0.31
chr12_94853936_94854087	0.25	CCDC41	coiled-coil domain containing 41	247	0.94
chr12_58223196_58223436	0.25	CTDSP2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	17	0.94
chr12_95868302_95868453	0.25	METAP2	methionyl aminopeptidase 2	439	0.84
chr10_129861675_129861865	0.25	PTPRE	protein tyrosine phosphatase, receptor type, E	15936	0.26
chr17_4607619_4607770	0.25	PELP1	proline, glutamate and leucine rich protein 1	62	0.63
chr3_107352295_107352521	0.25	BBX	bobby sox homolog (Drosophila)	12275	0.31
chr15_47476608_47476882	0.25	SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	447	0.85
chr1_35908347_35908498	0.24	KIAA0319L	KIAA0319-like	11886	0.17
chr1_22432425_22432576	0.24	WNT4	wingless-type MMTV integration site family, member 4	23844	0.15
chr14_52959290_52959441	0.24	TXNDC16	thioredoxin domain containing 16	59858	0.12
chr2_225905663_225905934	0.24	DOCK10	dedicator of cytokinesis 10	1361	0.55
chr18_61638270_61638435	0.24	SERPINB8	serpin peptidase inhibitor, clade B (ovalbumin), member 8	613	0.73
chr1_198744986_198745208	0.24	ENSG00000207975	.	83014	0.09
chr21_45077557_45077755	0.24	HSF2BP	heat shock transcription factor 2 binding protein	369	0.84
chr20_822843_822995	0.24	FAM110A	family with sequence similarity 110, member A	2366	0.35
chr11_10329277_10329428	0.24	ADM	adrenomedullin	2428	0.23
chr19_57351053_57351204	0.24	PEG3	paternally expressed 3	936	0.39
chr6_42858705_42858888	0.24	C6orf226	chromosome 6 open reading frame 226	242	0.88
chr2_113590430_113590581	0.24	IL1B	interleukin 1, beta	3506	0.21
chr13_50707168_50707390	0.24	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	50972	0.13
chr3_141030206_141030479	0.24	ZBTB38	zinc finger and BTB domain containing 38	12713	0.22
chr15_53080371_53080530	0.24	ONECUT1	one cut homeobox 1	1759	0.48
chr1_54665245_54665442	0.23	CYB5RL	cytochrome b5 reductase-like	342	0.59
chr16_84401523_84401674	0.23	ATP2C2	ATPase, Ca++ transporting, type 2C, member 2	535	0.79
chr10_81850627_81850778	0.23	TMEM254	transmembrane protein 254	9223	0.18
chr8_143859283_143859453	0.23	LYNX1	Ly6/neurotoxin 1	142	0.91
chr1_26362139_26362300	0.23	SLC30A2	solute carrier family 30 (zinc transporter), member 2	10385	0.1
chr22_50634186_50634337	0.23	TRABD	TraB domain containing	2818	0.11
chr15_89949515_89949757	0.23	ENSG00000207819	.	38388	0.14
chr21_45138541_45138692	0.23	PDXK	pyridoxal (pyridoxine, vitamin B6) kinase	359	0.88
chr14_24610403_24610554	0.23	EMC9	ER membrane protein complex subunit 9	301	0.7
chr2_177502756_177502963	0.23	ENSG00000252027	.	26545	0.25
chr4_1161143_1161294	0.23	RP11-20I20.4		348	0.81
chr15_56756676_56757156	0.23	MNS1	meiosis-specific nuclear structural 1	419	0.9
chr1_101701824_101702062	0.23	RP4-575N6.4		141	0.83
chr17_74380229_74380402	0.23	PRPSAP1	phosphoribosyl pyrophosphate synthetase-associated protein 1	250	0.55
chr6_26088017_26088347	0.23	HFE	hemochromatosis	515	0.56
chr8_81806183_81806334	0.23	ZNF704	zinc finger protein 704	19242	0.26
chr19_50935443_50935594	0.22	MYBPC2	myosin binding protein C, fast type	642	0.51
chr11_13300608_13301500	0.22	ARNTL	aryl hydrocarbon receptor nuclear translocator-like	1622	0.51
chrX_129090519_129090731	0.22	RP4-537K23.4		879	0.61
chr7_27162728_27162879	0.22	HOXA-AS2	HOXA cluster antisense RNA 2	16	0.93
chr1_149982777_149982991	0.22	OTUD7B	OTU domain containing 7B	259	0.9
chr13_31735240_31735730	0.22	HSPH1	heat shock 105kDa/110kDa protein 1	571	0.83
chr9_77112695_77112868	0.22	RORB	RAR-related orphan receptor B	500	0.75
chr19_4519048_4519199	0.22	PLIN4	perilipin 4	1407	0.24
chr19_45490552_45490703	0.22	CLPTM1	cleft lip and palate associated transmembrane protein 1	4899	0.1
chr1_33190488_33190689	0.22	RP11-114B7.6		250	0.9
chr17_46048605_46048756	0.22	CDK5RAP3	CDK5 regulatory subunit associated protein 3	163	0.9
chr6_82461023_82461181	0.22	FAM46A	family with sequence similarity 46, member A	368	0.88
chr16_31712181_31712332	0.22	CLUHP3	clustered mitochondria (cluA/CLU1) homolog pseudogene 3	2233	0.26
chr7_48285350_48285616	0.22	ABCA13	ATP-binding cassette, sub-family A (ABC1), member 13	74426	0.12
chr3_42623874_42624044	0.22	SEC22C	SEC22 vesicle trafficking protein homolog C (S. cerevisiae)	140	0.86

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F2_E2F5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.3	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.1	0.4	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.1	0.4	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.1	0.4	GO:0006089	lactate metabolic process(GO:0006089)
0.1	0.5	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.1	0.6	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.1	0.4	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.1	0.3	GO:0072162	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1	0.4	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.1	0.1	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.1	0.2	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.1	0.2	GO:0042816	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1	0.2	GO:0003079	obsolete positive regulation of natriuresis(GO:0003079)
0.1	0.4	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.1	0.5	GO:0033327	Leydig cell differentiation(GO:0033327)
0.1	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.1	0.1	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.1	0.2	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1	0.2	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.1	0.2	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.1	0.2	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.2	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.2	GO:0080111	DNA demethylation(GO:0080111)
0.0	0.2	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.2	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.6	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
0.0	0.5	GO:0035329	hippo signaling(GO:0035329)
0.0	0.2	GO:0061384	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.3	GO:0060134	prepulse inhibition(GO:0060134)
0.0	0.2	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.0	0.2	GO:0072070	loop of Henle development(GO:0072070)
0.0	0.1	GO:0034371	chylomicron remodeling(GO:0034371)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.1	GO:0010193	response to ozone(GO:0010193)
0.0	0.1	GO:0021778	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.3	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.2	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.0	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.1	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.1	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.1	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.1	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0	0.1	GO:0001705	ectoderm formation(GO:0001705)
0.0	0.0	GO:0051940	regulation of neurotransmitter uptake(GO:0051580) regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940)
0.0	0.1	GO:0032364	oxygen homeostasis(GO:0032364)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.4	GO:0018200	peptidyl-glutamic acid modification(GO:0018200)
0.0	0.2	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.0	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.0	0.0	GO:0052305	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308) positive regulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052555) positive regulation by symbiont of host immune response(GO:0052556)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.1	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0009405	pathogenesis(GO:0009405)
0.0	0.0	GO:2000192	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.1	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.2	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.1	GO:0060992	response to fungicide(GO:0060992)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.2	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.3	GO:0010039	response to iron ion(GO:0010039)
0.0	0.1	GO:0046855	phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.0	0.1	GO:0018344	protein geranylgeranylation(GO:0018344)
0.0	0.2	GO:0042474	middle ear morphogenesis(GO:0042474)
0.0	0.0	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0	0.4	GO:0014823	response to activity(GO:0014823)
0.0	0.0	GO:0009158	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.2	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.0	GO:1901320	negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.0	0.2	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.1	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.1	GO:0014832	urinary bladder smooth muscle contraction(GO:0014832)
0.0	0.4	GO:0006182	cGMP biosynthetic process(GO:0006182)
0.0	0.1	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.1	GO:0060292	long term synaptic depression(GO:0060292)
0.0	0.2	GO:0045806	negative regulation of endocytosis(GO:0045806)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.0	GO:0006188	IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.0	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.1	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.3	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0045416	positive regulation of interleukin-8 biosynthetic process(GO:0045416)
0.0	0.2	GO:0001958	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0	0.1	GO:0007097	nuclear migration(GO:0007097)
0.0	0.1	GO:0072010	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0030903	notochord development(GO:0030903)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.0	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.0	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.1	GO:0046051	GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051)
0.0	0.1	GO:1901678	iron coordination entity transport(GO:1901678)
0.0	0.1	GO:0098657	neurotransmitter uptake(GO:0001504) import into cell(GO:0098657)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.3	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.2	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.0	0.0	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.1	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.0	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.1	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.0	0.2	GO:0006862	nucleotide transport(GO:0006862)
0.0	0.1	GO:0006385	transcription elongation from RNA polymerase III promoter(GO:0006385) termination of RNA polymerase III transcription(GO:0006386)
0.0	0.0	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.0	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.1	GO:0009109	coenzyme catabolic process(GO:0009109)
0.0	0.0	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.4	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.0	0.1	GO:0048536	spleen development(GO:0048536)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.0	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.3	GO:0043928	nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0	0.1	GO:0070301	cellular response to hydrogen peroxide(GO:0070301)
0.0	0.3	GO:0051318	G1 phase(GO:0051318)
0.0	0.0	GO:0010613	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.2	GO:0005682	U5 snRNP(GO:0005682)
0.0	0.2	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.2	GO:0030914	STAGA complex(GO:0030914)
0.0	0.5	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.1	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.2	GO:0030681	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0	0.1	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.2	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.3	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.3	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	0.8	GO:0008287	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.3	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.3	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	0.1	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.7	GO:0000922	spindle pole(GO:0000922)
0.0	0.1	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0008328	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.0	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.4	GO:0036064	ciliary basal body(GO:0036064)
0.0	0.3	GO:0031526	brush border membrane(GO:0031526)
0.0	0.7	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.0	0.1	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.0	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.1	GO:0000805	X chromosome(GO:0000805)
0.0	0.1	GO:0032389	MutLalpha complex(GO:0032389)
0.0	0.1	GO:0042627	chylomicron(GO:0042627)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0030215	semaphorin receptor binding(GO:0030215)
0.2	0.5	GO:0051734	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.1	0.4	GO:0016882	cyclo-ligase activity(GO:0016882)
0.1	0.6	GO:0045499	chemorepellent activity(GO:0045499)
0.1	0.5	GO:0016004	phospholipase activator activity(GO:0016004)
0.1	0.3	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1	0.4	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.1	0.3	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	0.3	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.1	0.2	GO:0030548	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1	0.2	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.1	0.3	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.1	0.2	GO:0008420	CTD phosphatase activity(GO:0008420)
0.1	0.4	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.1	0.3	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.2	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.3	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.1	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.3	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.1	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.2	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.2	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.4	GO:0004835	tubulin-tyrosine ligase activity(GO:0004835)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.5	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.4	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.2	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.0	0.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.3	GO:0016986	obsolete transcription initiation factor activity(GO:0016986)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.3	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.3	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.0	0.2	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.1	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.8	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.0	0.1	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.1	GO:0004663	Rab geranylgeranyltransferase activity(GO:0004663)
0.0	0.1	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.1	GO:0001077	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	0.4	GO:0019201	nucleotide kinase activity(GO:0019201)
0.0	0.5	GO:0015036	disulfide oxidoreductase activity(GO:0015036)
0.0	0.0	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.2	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.0	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0016742	hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.0	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.1	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.2	GO:0015215	nucleotide transmembrane transporter activity(GO:0015215)
0.0	0.1	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.0	GO:0015605	organophosphate ester transmembrane transporter activity(GO:0015605)
0.0	0.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.0	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.1	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.0	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.5	GO:0003697	single-stranded DNA binding(GO:0003697)
0.0	0.0	GO:0048156	tau protein binding(GO:0048156)
0.0	0.0	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.0	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.0	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.0	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.2	GO:0008320	protein transmembrane transporter activity(GO:0008320)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.4	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.7	PID EPHB FWD PATHWAY	EPHB forward signaling
0.6	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.2	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.7	PID P53 REGULATION PATHWAY	p53 pathway
0.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.5	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.5	PID BMP PATHWAY	BMP receptor signaling
0.2	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.1	PID S1P S1P1 PATHWAY	S1P1 pathway
0.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.4	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.5	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.5	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.5	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.0	REACTOME GABA B RECEPTOR ACTIVATION	Genes involved in GABA B receptor activation
0.0	0.5	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.4	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.4	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.3	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.5	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.4	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	0.5	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.2	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.2	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.2	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.2	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.4	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	0.5	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.3	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.1	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.1	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
0.0	0.2	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.1	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.2	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0	0.2	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.1	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants