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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for E2F6

Z-value: 1.11

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Transcription factors associated with E2F6

Gene Symbol	Gene ID	Gene Info
E2F6 Ensembl NCBI GeneCards UniProt	ENSG00000169016.12	E2F6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
E2F6	chr2_11623681_11623832	17481	0.131240	-0.52	1.5e-01	Click!
E2F6	chr2_11622106_11622257	15906	0.134813	-0.51	1.6e-01	Click!
E2F6	chr2_11605347_11605717	473	0.729351	-0.48	1.9e-01	Click!
E2F6	chr2_11622351_11622584	16192	0.134166	-0.40	2.9e-01	Click!
E2F6	chr2_11622769_11622930	16574	0.133300	-0.39	3.0e-01	Click!

Activity of the E2F6 motif across conditions

Conditions sorted by the z-value of the E2F6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr22_39179164_39179315	0.52	SUN2	Sad1 and UNC84 domain containing 2	10909	0.09
chr1_8931641_8932436	0.42	ENO1-IT1	ENO1 intronic transcript 1 (non-protein coding)	6028	0.14
chr17_75311699_75312099	0.39	SEPT9	septin 9	3698	0.27
chr1_1476104_1476623	0.39	TMEM240	transmembrane protein 240	530	0.63
chr2_112896432_112896734	0.36	FBLN7	fibulin 7	423	0.88
chr17_36862672_36863533	0.35	CTB-58E17.3		588	0.44
chr9_128507884_128508777	0.33	PBX3	pre-B-cell leukemia homeobox 3	1294	0.56
chr12_6657819_6658220	0.33	IFFO1	intermediate filament family orphan 1	3047	0.1
chr21_35184316_35184478	0.32	ITSN1	intersectin 1 (SH3 domain protein)	12170	0.23
chr1_228603985_228604375	0.31	TRIM17	tripartite motif containing 17	148	0.9
chr17_77788487_77789261	0.31	ENSG00000238331	.	4396	0.16
chr19_850886_851037	0.31	ELANE	elastase, neutrophil expressed	53	0.94
chr1_156675699_156676565	0.31	CRABP2	cellular retinoic acid binding protein 2	524	0.6
chr3_53272501_53272842	0.30	TKT	transketolase	17345	0.13
chr6_81164529_81164680	0.30	BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	348221	0.01
chr15_83378361_83379204	0.29	AP3B2	adaptor-related protein complex 3, beta 2 subunit	116	0.95
chr12_132315122_132315695	0.29	MMP17	matrix metallopeptidase 17 (membrane-inserted)	2323	0.26
chr17_55945832_55946020	0.29	CUEDC1	CUE domain containing 1	1150	0.47
chr1_54686195_54686878	0.29	MRPL37	mitochondrial ribosomal protein L37	10917	0.13
chr8_99170182_99170517	0.29	ENSG00000252558	.	34192	0.13
chr1_44031055_44031511	0.28	PTPRF	protein tyrosine phosphatase, receptor type, F	20536	0.18
chr10_88160229_88160748	0.28	GRID1	glutamate receptor, ionotropic, delta 1	34253	0.17
chr17_56356237_56356388	0.28	MPO	myeloperoxidase	1984	0.23
chr15_90563466_90563923	0.28	ENSG00000265871	.	13707	0.14
chr10_123702458_123702803	0.28	ATE1	arginyltransferase 1	14314	0.17
chr11_69066370_69066772	0.27	MYEOV	myeloma overexpressed	4946	0.32
chr17_38082798_38082949	0.27	ORMDL3	ORM1-like 3 (S. cerevisiae)	221	0.89
chr1_203122833_203123125	0.27	RP11-335O13.8		951	0.45
chr1_68237207_68237358	0.26	ENSG00000238778	.	1054	0.59
chr13_53313127_53313462	0.26	LECT1	leukocyte cell derived chemotaxin 1	193	0.96
chr19_7989733_7990535	0.26	CTD-3193O13.8		752	0.29
chr5_76925321_76925875	0.26	WDR41	WD repeat domain 41	9162	0.23
chr4_157594425_157594576	0.26	RP11-171N4.3		30768	0.2
chr22_41843929_41844303	0.26	TOB2	transducer of ERBB2, 2	1089	0.43
chr9_36165368_36165519	0.25	CCIN	calicin	3946	0.21
chr9_139519589_139519822	0.25	ENSG00000252440	.	22738	0.09
chr14_71276457_71276666	0.25	MAP3K9	mitogen-activated protein kinase kinase kinase 9	310	0.94
chr2_87016233_87016699	0.25	CD8A	CD8a molecule	1482	0.41
chr10_105452470_105452921	0.24	SH3PXD2A	SH3 and PX domains 2A	235	0.93
chr11_3175380_3175656	0.24	OSBPL5	oxysterol binding protein-like 5	7105	0.16
chr5_180480179_180480493	0.24	BTNL9	butyrophilin-like 9	13070	0.16
chr11_12836667_12836952	0.24	RP11-47J17.3		8405	0.22
chr22_45521390_45521628	0.24	NUP50	nucleoporin 50kDa	38213	0.14
chr5_73556832_73556983	0.24	ENSG00000222551	.	10683	0.28
chr22_50422080_50422460	0.24	IL17REL	interleukin 17 receptor E-like	24851	0.15
chr22_36828593_36829238	0.24	ENSG00000252575	.	6056	0.16
chr5_172327841_172328220	0.24	ERGIC1	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1	4190	0.22
chr10_81027570_81027806	0.23	ZMIZ1	zinc finger, MIZ-type containing 1	38287	0.19
chr4_77675626_77675892	0.23	RP11-359D14.2		3868	0.27
chr9_139510576_139510771	0.23	ENSG00000252440	.	13706	0.1
chr20_58520957_58521211	0.23	FAM217B	family with sequence similarity 217, member B	3905	0.19
chr19_1513130_1513873	0.23	ADAMTSL5	ADAMTS-like 5	313	0.73
chr6_11044071_11044432	0.23	ELOVL2-AS1	ELOVL2 antisense RNA 1	258	0.53
chr17_32574614_32574944	0.23	CCL2	chemokine (C-C motif) ligand 2	7525	0.13
chr11_925206_925651	0.23	AP2A2	adaptor-related protein complex 2, alpha 2 subunit	444	0.71
chr3_120180997_120181426	0.23	FSTL1	follistatin-like 1	11111	0.26
chr12_65700883_65701407	0.23	MSRB3	methionine sulfoxide reductase B3	19510	0.22
chr1_114525815_114526112	0.23	OLFML3	olfactomedin-like 3	3268	0.23
chr8_105478631_105479267	0.23	DPYS	dihydropyrimidinase	323	0.87
chr2_25475353_25475794	0.23	DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	393	0.88
chr19_728237_728510	0.22	PALM	paralemmin	19272	0.09
chr6_154640196_154640597	0.22	IPCEF1	interaction protein for cytohesin exchange factors 1	10819	0.3
chr2_174053187_174053569	0.22	MLK7-AS1	MLK7 antisense RNA 1	18962	0.26
chr2_20715345_20715496	0.22	ENSG00000200829	.	34815	0.16
chr22_45622655_45622806	0.22	KIAA0930	KIAA0930	54	0.97
chr17_48114815_48114966	0.22	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	18449	0.13
chr9_124581839_124582120	0.22	RP11-244O19.1		248	0.95
chr21_47485945_47486454	0.22	AP001471.1		31245	0.13
chr9_132096828_132097338	0.22	ENSG00000242281	.	35657	0.16
chr12_120662468_120662643	0.21	PXN	paxillin	2	0.96
chr16_24679897_24680048	0.21	TNRC6A	trinucleotide repeat containing 6A	61044	0.14
chr10_126791455_126791637	0.21	CTBP2	C-terminal binding protein 2	55739	0.14
chr17_80655614_80655903	0.21	RAB40B	RAB40B, member RAS oncogene family	780	0.49
chr12_63544901_63545298	0.21	AVPR1A	arginine vasopressin receptor 1A	377	0.93
chr1_8676963_8677114	0.21	RERE	arginine-glutamic acid dipeptide (RE) repeats	7401	0.28
chr9_14322498_14322883	0.21	NFIB	nuclear factor I/B	353	0.91
chr17_72039340_72039491	0.21	RPL38	ribosomal protein L38	160306	0.03
chr17_37353315_37353878	0.21	CACNB1	calcium channel, voltage-dependent, beta 1 subunit	359	0.79
chr3_23653779_23653992	0.21	ENSG00000252562	.	1365	0.51
chr9_140009377_140009643	0.21	DPP7	dipeptidyl-peptidase 7	119	0.88
chr3_120279483_120279766	0.21	NDUFB4	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa	35532	0.19
chr3_190580663_190581079	0.21	GMNC	geminin coiled-coil domain containing	467	0.9
chr3_42692749_42693153	0.21	ZBTB47	zinc finger and BTB domain containing 47	2225	0.17
chr4_157996843_157997211	0.21	GLRB	glycine receptor, beta	182	0.96
chr4_4388363_4388660	0.21	NSG1	Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.	246	0.94
chr10_6243827_6244661	0.21	RP11-414H17.5		412	0.58
chr2_86450156_86450475	0.21	MRPL35	mitochondrial ribosomal protein L35	23729	0.12
chr9_137118247_137118684	0.21	ENSG00000221676	.	88779	0.07
chr7_127306838_127306989	0.21	SND1	staphylococcal nuclease and tudor domain containing 1	14679	0.17
chr3_120278487_120278806	0.21	NDUFB4	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa	36510	0.19
chr4_20432301_20432452	0.20	SLIT2-IT1	SLIT2 intronic transcript 1 (non-protein coding)	38564	0.21
chr6_44044467_44044818	0.20	RP5-1120P11.1		2253	0.28
chr12_26428456_26429005	0.20	RP11-283G6.5		3877	0.25
chr2_129062963_129063193	0.20	HS6ST1	heparan sulfate 6-O-sulfotransferase 1	13073	0.24
chr17_41016311_41016609	0.20	AOC4P	amine oxidase, copper containing 4, pseudogene	2836	0.12
chr17_42872109_42872587	0.20	GJC1	gap junction protein, gamma 1, 45kDa	9986	0.14
chr1_15273356_15273566	0.20	KAZN	kazrin, periplakin interacting protein	1046	0.69
chr1_33800790_33801246	0.20	ENSG00000222112	.	1447	0.27
chr7_128531158_128531719	0.20	ENSG00000221401	.	15387	0.13
chr1_19977045_19977345	0.20	NBL1	neuroblastoma 1, DAN family BMP antagonist	3091	0.21
chr16_85932462_85932735	0.20	IRF8	interferon regulatory factor 8	171	0.96
chr10_81058240_81058391	0.20	ZMIZ1	zinc finger, MIZ-type containing 1	7660	0.25
chr4_38566945_38567096	0.20	RP11-617D20.1		59176	0.13
chr9_84305434_84305645	0.20	TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	1319	0.53
chr1_56942959_56943169	0.20	ENSG00000223307	.	99974	0.08
chr1_236105296_236105530	0.19	ENSG00000206803	.	26698	0.17
chr11_43942650_43942801	0.19	RP11-613D13.4		99	0.68
chr10_75685865_75686026	0.19	C10orf55	chromosome 10 open reading frame 55	3410	0.19
chr12_121890704_121890855	0.19	RNF34	ring finger protein 34, E3 ubiquitin protein ligase	43501	0.13
chr1_156120275_156120768	0.19	SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	711	0.53
chr10_102279085_102279348	0.19	SEC31B	SEC31 homolog B (S. cerevisiae)	375	0.84
chr16_86806513_86806664	0.19	FOXL1	forkhead box L1	194473	0.03
chr21_47714776_47715544	0.19	YBEY	ybeY metallopeptidase (putative)	8601	0.11
chr8_134388401_134388552	0.19	NDRG1	N-myc downstream regulated 1	74211	0.11
chr18_76740387_76741175	0.19	SALL3	spalt-like transcription factor 3	506	0.87
chr20_25604864_25605138	0.19	ZNF337-AS1	ZNF337 antisense RNA 1	132	0.58
chr16_73104328_73104761	0.19	ZFHX3	zinc finger homeobox 3	10947	0.24
chr3_171596267_171596418	0.19	TMEM212-IT1	TMEM212 intronic transcript 1 (non-protein coding)	15884	0.2
chr7_107254455_107254606	0.19	ENSG00000238832	.	10722	0.14
chr19_45248669_45248985	0.19	BCL3	B-cell CLL/lymphoma 3	2977	0.15
chr6_43097250_43097447	0.19	PTK7	protein tyrosine kinase 7	981	0.43
chr4_13549043_13549422	0.19	NKX3-2	NK3 homeobox 2	2558	0.32
chr12_125052866_125053278	0.19	NCOR2	nuclear receptor corepressor 2	1062	0.68
chr17_73521888_73522295	0.19	LLGL2	lethal giant larvae homolog 2 (Drosophila)	221	0.88
chr8_99468654_99468805	0.19	ENSG00000207378	.	6549	0.21
chr7_126893149_126893382	0.19	GRM8	glutamate receptor, metabotropic 8	83	0.98
chr15_72522895_72523387	0.19	PKM	pyruvate kinase, muscle	313	0.87
chr22_44704706_44704857	0.19	KIAA1644	KIAA1644	3950	0.31
chr11_66102916_66103067	0.19	RIN1	Ras and Rab interactor 1	886	0.25
chr1_22236518_22236840	0.19	HSPG2	heparan sulfate proteoglycan 2	13876	0.16
chr7_128431078_128431544	0.19	CCDC136	coiled-coil domain containing 136	153	0.93
chr19_33790905_33791151	0.19	CTD-2540B15.11		188	0.87
chr17_76370784_76371498	0.19	PGS1	phosphatidylglycerophosphate synthase 1	3580	0.16
chr12_104770624_104770775	0.19	TXNRD1	thioredoxin reductase 1	67070	0.1
chr6_43740851_43741100	0.19	VEGFA	vascular endothelial growth factor A	1115	0.46
chr19_1099011_1099283	0.18	POLR2E	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	3549	0.12
chr10_77718805_77719099	0.18	ENSG00000215921	.	135416	0.05
chr22_50344908_50345281	0.18	PIM3	pim-3 oncogene	9067	0.17
chr4_675635_675881	0.18	MYL5	myosin, light chain 5, regulatory	3780	0.12
chr19_35786776_35787077	0.18	MAG	myelin associated glycoprotein	3862	0.11
chr14_68864088_68864387	0.18	RAD51B	RAD51 paralog B	13990	0.28
chr6_125425186_125425448	0.18	TPD52L1	tumor protein D52-like 1	14878	0.26
chr5_172297414_172297971	0.18	ERGIC1	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1	34528	0.14
chr15_98509107_98509579	0.18	ARRDC4	arrestin domain containing 4	5415	0.27
chr1_32178967_32179267	0.18	COL16A1	collagen, type XVI, alpha 1	9197	0.14
chr3_48590196_48590347	0.18	PFKFB4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	3985	0.12
chr2_9293102_9293360	0.18	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	53663	0.16
chr11_2847111_2847315	0.18	KCNQ1-AS1	KCNQ1 antisense RNA 1	35585	0.12
chr11_75140643_75140996	0.18	KLHL35	kelch-like family member 35	417	0.77
chr12_48276558_48277156	0.18	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	139	0.8
chr12_56882110_56882566	0.18	GLS2	glutaminase 2 (liver, mitochondrial)	157	0.93
chr11_67781609_67782080	0.18	ALDH3B1	aldehyde dehydrogenase 3 family, member B1	4054	0.13
chr5_72672425_72672576	0.18	FOXD1	forkhead box D1	71852	0.1
chr10_129726535_129726686	0.18	RP11-4C20.4		6352	0.23
chr13_114563717_114564199	0.18	GAS6	growth arrest-specific 6	3082	0.32
chr1_110363596_110363760	0.18	EPS8L3	EPS8-like 3	57029	0.08
chr22_46505362_46505513	0.18	ENSG00000198986	.	3192	0.13
chr8_6519065_6519216	0.18	CTD-2541M15.1		12812	0.22
chr3_194921339_194921490	0.18	ENSG00000206600	.	14102	0.16
chr19_18548066_18548217	0.18	ISYNA1	inositol-3-phosphate synthase 1	22	0.95
chr14_77384650_77384809	0.18	ENSG00000223174	.	28123	0.17
chr14_23771801_23772188	0.18	PPP1R3E	protein phosphatase 1, regulatory subunit 3E	63	0.92
chr6_71958092_71958555	0.18	RP11-154D6.1		36312	0.16
chr3_184301748_184302108	0.18	EPHB3	EPH receptor B3	22356	0.17
chr4_79487146_79487361	0.17	ANXA3	annexin A3	12179	0.24
chr21_44809582_44809733	0.17	SIK1	salt-inducible kinase 1	37351	0.2
chr10_114881000_114881218	0.17	TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	22570	0.27
chr22_41405475_41405715	0.17	ENSG00000222698	.	35906	0.11
chr7_91788801_91788952	0.17	LRRD1	leucine-rich repeats and death domain containing 1	5714	0.15
chr13_52769511_52769985	0.17	MRPS31P5	mitochondrial ribosomal protein S31 pseudogene 5	1235	0.51
chr2_9400376_9400527	0.17	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	53557	0.16
chr11_27740496_27740764	0.17	BDNF	brain-derived neurotrophic factor	664	0.79
chr7_17730022_17730173	0.17	SNX13	sorting nexin 13	249994	0.02
chr20_62273575_62273807	0.17	STMN3	stathmin-like 3	10428	0.1
chr9_32431789_32431940	0.17	ACO1	aconitase 1, soluble	47246	0.14
chr6_158142657_158142808	0.17	SNX9	sorting nexin 9	101564	0.07
chr3_87841746_87841974	0.17	ENSG00000200703	.	50061	0.18
chr2_38084910_38085061	0.17	RMDN2	regulator of microtubule dynamics 2	65345	0.13
chr2_241506212_241507153	0.17	RNPEPL1	arginyl aminopeptidase (aminopeptidase B)-like 1	1422	0.26
chr6_6795563_6795740	0.17	ENSG00000240936	.	143479	0.04
chr9_95873753_95873904	0.17	C9orf89	chromosome 9 open reading frame 89	15328	0.15
chr1_155035496_155036067	0.17	EFNA4	ephrin-A4	426	0.41
chr2_118981232_118982329	0.17	INSIG2	insulin induced gene 2	135730	0.05
chr2_10184378_10184666	0.17	KLF11	Kruppel-like factor 11	150	0.93
chr19_12912283_12912701	0.17	PRDX2	peroxiredoxin 2	109	0.89
chr16_84956251_84956402	0.17	ZDHHC7	zinc finger, DHHC-type containing 7	59397	0.1
chr21_46963567_46964113	0.17	SLC19A1	solute carrier family 19 (folate transporter), member 1	474	0.84
chr15_40544709_40545241	0.17	PAK6	p21 protein (Cdc42/Rac)-activated kinase 6	114	0.52
chr7_5458267_5458922	0.17	AC093620.5		864	0.36
chr1_40423957_40424317	0.17	MFSD2A	major facilitator superfamily domain containing 2A	3315	0.2
chr6_155053378_155054103	0.17	SCAF8	SR-related CTD-associated factor 8	719	0.76
chr19_39919469_39919620	0.17	PLEKHG2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	4133	0.09
chr17_983655_983915	0.17	ABR	active BCR-related	1399	0.45
chr15_67316146_67316685	0.17	SMAD3	SMAD family member 3	39686	0.2
chr16_4323567_4324032	0.17	TFAP4	transcription factor AP-4 (activating enhancer binding protein 4)	723	0.63
chr16_521494_521645	0.17	RAB11FIP3	RAB11 family interacting protein 3 (class II)	3281	0.13
chr20_48920943_48921193	0.17	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	113692	0.05
chr14_25518403_25519489	0.17	STXBP6	syntaxin binding protein 6 (amisyn)	149	0.98
chr20_4230129_4230416	0.17	ADRA1D	adrenoceptor alpha 1D	551	0.82
chr5_392750_392913	0.17	AHRR	aryl-hydrocarbon receptor repressor	28204	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.1	0.3	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.1	0.3	GO:0071462	cellular response to water stimulus(GO:0071462)
0.1	0.2	GO:0048368	lateral mesoderm development(GO:0048368)
0.1	0.2	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.1	0.2	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.1	0.3	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	0.2	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.1	0.2	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1	0.3	GO:0007386	compartment pattern specification(GO:0007386)
0.1	0.1	GO:0014055	acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526)
0.1	0.1	GO:0032261	purine nucleotide salvage(GO:0032261)
0.1	0.2	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.2	GO:0060013	righting reflex(GO:0060013)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.2	GO:0032878	regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0	0.1	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.2	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.0	GO:0045721	negative regulation of gluconeogenesis(GO:0045721)
0.0	0.2	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.2	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.2	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:1903521	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.2	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.2	GO:0010700	negative regulation of norepinephrine secretion(GO:0010700)
0.0	0.2	GO:0021891	olfactory bulb interneuron development(GO:0021891)
0.0	0.2	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0022010	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0	0.3	GO:0003085	negative regulation of systemic arterial blood pressure(GO:0003085)
0.0	0.2	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.0	0.1	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.1	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.0	GO:0043173	nucleotide salvage(GO:0043173)
0.0	0.1	GO:0030497	fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
0.0	0.1	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0046881	positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.1	GO:0071681	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0	0.2	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.1	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.2	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.0	0.0	GO:0001992	regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0	0.1	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.1	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.1	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0045945	positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0	0.0	GO:0046084	adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.1	GO:0061117	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0021843	substrate-independent telencephalic tangential migration(GO:0021826) interneuron migration from the subpallium to the cortex(GO:0021830) substrate-independent telencephalic tangential interneuron migration(GO:0021843) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0	0.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.2	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.2	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0071294	cellular response to zinc ion(GO:0071294)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development(GO:0060768) negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0071549	cellular response to dexamethasone stimulus(GO:0071549)
0.0	0.1	GO:0072160	nephron tubule epithelial cell differentiation(GO:0072160) regulation of nephron tubule epithelial cell differentiation(GO:0072182) regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
0.0	0.1	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.0	0.1	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.1	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.2	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0005997	xylulose metabolic process(GO:0005997)
0.0	0.1	GO:0090598	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.1	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0	0.1	GO:0046958	nonassociative learning(GO:0046958)
0.0	0.2	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.0	GO:0071605	monocyte chemotactic protein-1 production(GO:0071605) regulation of monocyte chemotactic protein-1 production(GO:0071637)
0.0	0.1	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.1	GO:1903670	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.1	GO:0015732	prostaglandin transport(GO:0015732)
0.0	0.1	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.0	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.1	GO:0046838	phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0	0.1	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.0	GO:0060087	relaxation of smooth muscle(GO:0044557) negative regulation of smooth muscle contraction(GO:0045986) relaxation of vascular smooth muscle(GO:0060087)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.0	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.0	GO:0021859	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.0	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0033133	regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.0	0.2	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.1	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.0	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.0	GO:0021800	cerebral cortex tangential migration(GO:0021800)
0.0	0.2	GO:0071450	removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0	0.1	GO:0034204	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.2	GO:0046697	decidualization(GO:0046697)
0.0	0.0	GO:0090075	relaxation of muscle(GO:0090075)
0.0	0.0	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.0	GO:0060431	foregut regionalization(GO:0060423) lung field specification(GO:0060424) primary lung bud formation(GO:0060431) lung induction(GO:0060492) positive regulation of branching involved in lung morphogenesis(GO:0061047)
0.0	0.0	GO:0060004	reflex(GO:0060004)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.0	GO:0044803	multi-organism membrane organization(GO:0044803)
0.0	0.1	GO:0042940	D-amino acid transport(GO:0042940)
0.0	0.0	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.1	GO:0007130	synaptonemal complex assembly(GO:0007130)
0.0	0.1	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.1	GO:0060080	inhibitory postsynaptic potential(GO:0060080)
0.0	0.0	GO:0021884	forebrain neuron development(GO:0021884)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.3	GO:0014047	glutamate secretion(GO:0014047)
0.0	0.1	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.0	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.1	GO:0051459	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.0	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.1	GO:0002069	columnar/cuboidal epithelial cell maturation(GO:0002069)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.0	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.2	GO:0043277	apoptotic cell clearance(GO:0043277)
0.0	0.1	GO:0051898	negative regulation of protein kinase B signaling(GO:0051898)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.0	GO:1901534	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.0	GO:0002885	positive regulation of hypersensitivity(GO:0002885)
0.0	0.1	GO:0016246	RNA interference(GO:0016246)
0.0	0.3	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.1	GO:0002052	positive regulation of neuroblast proliferation(GO:0002052)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0032364	oxygen homeostasis(GO:0032364)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.1	GO:0031338	regulation of vesicle fusion(GO:0031338)
0.0	0.1	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.1	GO:0048240	sperm capacitation(GO:0048240)
0.0	0.1	GO:0071285	cellular response to lithium ion(GO:0071285)
0.0	0.0	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.0	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.1	GO:0045080	positive regulation of chemokine biosynthetic process(GO:0045080)
0.0	0.1	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.0	GO:0044320	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.0	GO:0072131	kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0	0.1	GO:0031065	positive regulation of histone deacetylation(GO:0031065)
0.0	0.1	GO:0001967	suckling behavior(GO:0001967)
0.0	0.1	GO:0021535	cell migration in hindbrain(GO:0021535)
0.0	0.1	GO:0070265	necrotic cell death(GO:0070265)
0.0	0.1	GO:0048016	inositol phosphate-mediated signaling(GO:0048016)
0.0	0.0	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0060122	inner ear receptor stereocilium organization(GO:0060122)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.1	GO:0051788	response to misfolded protein(GO:0051788)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.0	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.0	0.2	GO:0051350	negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350)
0.0	0.2	GO:0042573	retinoic acid metabolic process(GO:0042573)
0.0	0.1	GO:1901678	iron coordination entity transport(GO:1901678)
0.0	0.0	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.2	GO:0008333	endosome to lysosome transport(GO:0008333)
0.0	0.1	GO:0020027	hemoglobin metabolic process(GO:0020027)
0.0	0.3	GO:0051925	obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)
0.0	0.0	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.0	GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145)
0.0	0.1	GO:0016056	rhodopsin mediated signaling pathway(GO:0016056)
0.0	0.0	GO:0045007	depurination(GO:0045007)
0.0	0.0	GO:0031034	skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.0	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.0	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0	0.0	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.0	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.0	GO:1901374	acetylcholine transport(GO:0015870) acetate ester transport(GO:1901374)
0.0	0.1	GO:0021954	central nervous system neuron development(GO:0021954)
0.0	0.0	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.0	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.0	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.0	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.0	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.0	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.0	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.1	GO:1900087	traversing start control point of mitotic cell cycle(GO:0007089) positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.0	GO:0001553	luteinization(GO:0001553)
0.0	0.1	GO:0006837	serotonin transport(GO:0006837)
0.0	0.0	GO:0046618	drug export(GO:0046618)
0.0	0.0	GO:0033622	integrin activation(GO:0033622)
0.0	0.0	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.0	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.6	GO:0006892	post-Golgi vesicle-mediated transport(GO:0006892)
0.0	0.1	GO:0007635	chemosensory behavior(GO:0007635)
0.0	0.1	GO:0043922	negative regulation by host of viral transcription(GO:0043922)
0.0	0.1	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:1902221	L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0	0.1	GO:0042403	thyroid hormone metabolic process(GO:0042403)
0.0	0.1	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0	0.1	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:0010107	potassium ion import(GO:0010107)
0.0	0.0	GO:0019605	butyrate metabolic process(GO:0019605)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.0	GO:0032352	positive regulation of hormone metabolic process(GO:0032352) positive regulation of hormone biosynthetic process(GO:0046886)
0.0	0.1	GO:0046349	amino sugar biosynthetic process(GO:0046349)
0.0	0.0	GO:0002042	cell migration involved in sprouting angiogenesis(GO:0002042)
0.0	0.0	GO:0019532	oxalate transport(GO:0019532)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.3	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0016600	flotillin complex(GO:0016600)
0.0	0.2	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0060199	clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.2	GO:0000791	euchromatin(GO:0000791)
0.0	0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.0	GO:0031045	dense core granule(GO:0031045)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.0	GO:0070081	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0	0.2	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.0	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	0.1	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0033150	cytoskeletal calyx(GO:0033150)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.3	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.2	GO:0005720	nuclear heterochromatin(GO:0005720)
0.0	0.1	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.1	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.3	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.0	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.2	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	0.1	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.1	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0042641	actomyosin(GO:0042641)
0.0	0.0	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.0	0.2	GO:0030057	desmosome(GO:0030057)
0.0	0.0	GO:0032432	actin filament bundle(GO:0032432)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.0	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.2	GO:0031201	SNARE complex(GO:0031201)
0.0	0.0	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.3	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.1	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.0	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.0	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.0	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	1.1	GO:0005925	focal adhesion(GO:0005925)
0.0	0.0	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.1	0.2	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	0.3	GO:0004111	creatine kinase activity(GO:0004111)
0.1	0.3	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	0.2	GO:0008518	reduced folate carrier activity(GO:0008518)
0.1	0.2	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.1	0.2	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1	0.2	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.1	0.3	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.2	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0004052	arachidonate 12-lipoxygenase activity(GO:0004052)
0.0	0.4	GO:0017166	vinculin binding(GO:0017166)
0.0	0.2	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.2	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0004936	alpha-adrenergic receptor activity(GO:0004936) alpha2-adrenergic receptor activity(GO:0004938)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.2	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.3	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.2	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.2	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.2	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0051380	adrenergic receptor activity(GO:0004935) beta-adrenergic receptor activity(GO:0004939) epinephrine binding(GO:0051379) norepinephrine binding(GO:0051380)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.2	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.2	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.3	GO:0008430	selenium binding(GO:0008430)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.0	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0004415	hyalurononglucosaminidase activity(GO:0004415)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0017089	glycolipid transporter activity(GO:0017089)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.2	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.0	0.2	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.2	GO:0019841	retinol binding(GO:0019841)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.2	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.2	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.2	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.0	GO:0048039	ubiquinone binding(GO:0048039)
0.0	0.1	GO:0008967	phosphoglycolate phosphatase activity(GO:0008967)
0.0	0.1	GO:1901567	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0005112	Notch binding(GO:0005112)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.0	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.0	GO:0004802	transketolase activity(GO:0004802)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.0	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0098988	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0	0.0	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.0	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.0	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.0	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.3	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.0	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.0	GO:0016744	transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0	0.2	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.1	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.3	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.0	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.2	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.0	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.0	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.0	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.0	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.1	GO:0048185	activin binding(GO:0048185)
0.0	0.0	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.0	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.3	GO:0004601	peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.0	0.0	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.0	0.0	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.0	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.1	GO:0022821	potassium ion antiporter activity(GO:0022821)
0.0	0.1	GO:0019104	DNA N-glycosylase activity(GO:0019104)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.0	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.0	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.1	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.0	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	PID REELIN PATHWAY	Reelin signaling pathway
0.7	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.4	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.2	PID S1P S1P1 PATHWAY	S1P1 pathway
0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.5	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.1	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.3	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.3	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.3	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.4	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.2	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.2	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	REACTOME OPIOID SIGNALLING	Genes involved in Opioid Signalling
0.1	REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	Genes involved in Integrin alphaIIb beta3 signaling
0.4	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.1	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.0	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.2	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.1	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.2	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.1	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling