CREMA results: E2F6

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Transcription factors associated with E2F6

Gene Symbol	Gene ID	Gene Info
E2F6 Ensembl NCBI GeneCards UniProt	ENSG00000169016.12	E2F transcription factor 6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr2_11605347_11605717	E2F6	473	0.729351	-0.48	1.9e-01	Click!
chr2_11622106_11622257	E2F6	15906	0.134813	-0.51	1.6e-01	Click!
chr2_11622351_11622584	E2F6	16192	0.134166	-0.40	2.9e-01	Click!
chr2_11622769_11622930	E2F6	16574	0.133300	-0.39	3.0e-01	Click!
chr2_11623681_11623832	E2F6	17481	0.131240	-0.52	1.5e-01	Click!

Showing 1 to 5 of 5 entries

Activity of the E2F6 motif across conditions

Conditions sorted by the z-value of the E2F6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr22_39179164_39179315	0.52	SUN2	Sad1 and UNC84 domain containing 2	10909	0.09
chr1_8931641_8932436	0.42	ENO1-IT1	ENO1 intronic transcript 1 (non-protein coding)	6028	0.14
chr17_75311699_75312099	0.39	SEPT9	septin 9	3698	0.27
chr1_1476104_1476623	0.39	TMEM240	transmembrane protein 240	530	0.63
chr2_112896432_112896734	0.36	FBLN7	fibulin 7	423	0.88
chr17_36862672_36863533	0.35	CTB-58E17.3		588	0.44
chr9_128507884_128508777	0.33	PBX3	pre-B-cell leukemia homeobox 3	1294	0.56
chr12_6657819_6658220	0.33	IFFO1	intermediate filament family orphan 1	3047	0.1
chr21_35184316_35184478	0.32	ITSN1	intersectin 1 (SH3 domain protein)	12170	0.23
chr1_228603985_228604375	0.31	TRIM17	tripartite motif containing 17	148	0.9

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0006892	post-Golgi vesicle-mediated transport(GO:0006892)
0.1	0.3	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.1	0.3	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.1	0.3	GO:0071462	cellular response to water stimulus(GO:0071462)
0.1	0.3	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	0.3	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.3	GO:0003085	negative regulation of systemic arterial blood pressure(GO:0003085)
0.0	0.3	GO:0014047	glutamate secretion(GO:0014047)
0.0	0.3	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.3	GO:0051925	obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)

Showing 1 to 10 of 226 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	GO:0005925	focal adhesion(GO:0005925)
0.1	0.3	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.3	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.3	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.3	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.3	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.2	GO:0016600	flotillin complex(GO:0016600)
0.0	0.2	GO:0042587	glycogen granule(GO:0042587)
0.0	0.2	GO:0000791	euchromatin(GO:0000791)
0.0	0.2	GO:0002102	podosome(GO:0002102)

Showing 1 to 10 of 62 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0017166	vinculin binding(GO:0017166)
0.1	0.3	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.1	0.3	GO:0004111	creatine kinase activity(GO:0004111)
0.1	0.3	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	0.3	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.3	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.3	GO:0008430	selenium binding(GO:0008430)
0.0	0.3	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.3	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.3	GO:0004601	peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)

Showing 1 to 10 of 135 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.7	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.4	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.2	PID S1P S1P1 PATHWAY	S1P1 pathway
0.1	PID REELIN PATHWAY	Reelin signaling pathway
0.1	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.5	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.4	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.4	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.3	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.3	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP

Showing 1 to 10 of 37 entries

Results for E2F6

Z-value: 1.11

Motif logo

Transcription factors associated with E2F6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the E2F6 motif across conditions

Conditions sorted by the z-value of the E2F6 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: