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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for E2F8

Z-value: 1.58

Motif logo

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Transcription factors associated with E2F8

Gene Symbol Gene ID Gene Info
ENSG00000129173.8 E2F8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
E2F8chr11_19261961_192622304030.8574300.608.5e-02Click!
E2F8chr11_19305428_19305803424480.1354420.581.0e-01Click!
E2F8chr11_19298540_19298691354480.152214-0.521.5e-01Click!
E2F8chr11_19254592_1925474378310.193574-0.491.8e-01Click!
E2F8chr11_19266201_1926635531110.262131-0.472.0e-01Click!

Activity of the E2F8 motif across conditions

Conditions sorted by the z-value of the E2F8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr9_92138368_92138605 0.48 SEMA4D
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
25441
0.19
chr6_24920336_24920683 0.46 FAM65B
family with sequence similarity 65, member B
9314
0.23
chr8_95941718_95941912 0.46 TP53INP1
tumor protein p53 inducible nuclear protein 1
11386
0.13
chr11_48041048_48041486 0.44 AC103828.1

3860
0.26
chr11_74987512_74987913 0.44 ARRB1
arrestin, beta 1
2031
0.24
chr13_52396732_52397247 0.42 RP11-327P2.5

18556
0.18
chr4_185150814_185151001 0.41 ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
8524
0.22
chr6_15246484_15246635 0.40 JARID2
jumonji, AT rich interactive domain 2
32
0.98
chr2_205831873_205832072 0.39 PARD3B
par-3 family cell polarity regulator beta
421249
0.01
chr15_75900898_75901062 0.39 SNUPN
snurportin 1
8885
0.11
chr17_25784455_25784823 0.39 KSR1
kinase suppressor of ras 1
899
0.6
chr9_140345198_140345349 0.39 NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor
3671
0.14
chr16_4316350_4316501 0.38 TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
2687
0.23
chr14_100560569_100560771 0.38 EVL
Enah/Vasp-like
2614
0.2
chr2_241342781_241342932 0.38 GPC1
glypican 1
32232
0.15
chr12_21766695_21766846 0.37 GYS2
glycogen synthase 2 (liver)
8989
0.2
chr17_61780107_61780446 0.37 STRADA
STE20-related kinase adaptor alpha
1539
0.28
chr22_37620705_37620902 0.37 SSTR3
somatostatin receptor 3
12441
0.13
chr1_200994706_200994917 0.37 KIF21B
kinesin family member 21B
1983
0.32
chr19_16960816_16960967 0.37 CTD-2538G9.5

6055
0.13
chr20_32446812_32447014 0.37 CHMP4B
charged multivesicular body protein 4B
47803
0.12
chr1_154438061_154438451 0.36 RP11-350G8.9

14232
0.12
chr5_169703034_169703822 0.36 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
9097
0.23
chr1_206940002_206940347 0.36 IL10
interleukin 10
5665
0.17
chr3_101774516_101774796 0.35 ZPLD1
zona pellucida-like domain containing 1
43432
0.18
chrX_38529055_38529246 0.35 ENSG00000238606
.
61682
0.13
chr7_56118702_56118950 0.35 PSPH
phosphoserine phosphatase
155
0.79
chr14_22973101_22973316 0.35 TRAJ51
T cell receptor alpha joining 51 (pseudogene)
17037
0.09
chr1_153848148_153848299 0.34 GATAD2B
GATA zinc finger domain containing 2B
47228
0.08
chr5_130710388_130710539 0.34 CDC42SE2
CDC42 small effector 2
10836
0.3
chr22_17700910_17701256 0.34 CECR1
cat eye syndrome chromosome region, candidate 1
758
0.68
chr9_271617_272065 0.34 RP11-59O6.3

1161
0.37
chr2_175315188_175315339 0.34 GPR155
G protein-coupled receptor 155
36502
0.14
chr1_212209141_212209453 0.33 DTL
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
205
0.71
chr17_66250172_66250736 0.33 AMZ2
archaelysin family metallopeptidase 2
4126
0.18
chr20_43657355_43657581 0.33 ENSG00000252021
.
24479
0.14
chr18_66381488_66381790 0.33 TMX3
thioredoxin-related transmembrane protein 3
655
0.52
chr10_6549756_6549940 0.33 PRKCQ
protein kinase C, theta
72353
0.12
chr8_134086760_134086925 0.33 SLA
Src-like-adaptor
14239
0.23
chr4_4857303_4857507 0.33 MSX1
msh homeobox 1
3988
0.32
chr10_6571808_6571959 0.33 PRKCQ
protein kinase C, theta
50318
0.18
chr14_93159341_93159532 0.33 LGMN
legumain
24368
0.21
chrX_70321837_70321988 0.33 CXorf65
chromosome X open reading frame 65
4543
0.12
chr3_43388752_43388982 0.33 RP11-188P20.3

268
0.91
chr10_121334352_121334503 0.33 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
13295
0.21
chr11_118177738_118177927 0.32 CD3E
CD3e molecule, epsilon (CD3-TCR complex)
2218
0.21
chr5_74354344_74354509 0.32 GCNT4
glucosaminyl (N-acetyl) transferase 4, core 2
27702
0.23
chr18_13379607_13379896 0.32 LDLRAD4
low density lipoprotein receptor class A domain containing 4
2802
0.23
chr2_239402597_239402871 0.32 AC016999.2

66364
0.1
chr3_37998819_37999085 0.32 CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
7118
0.16
chr16_71914316_71914975 0.32 ZNF821
zinc finger protein 821
677
0.52
chr10_48481902_48482094 0.32 GDF10
growth differentiation factor 10
43022
0.14
chr1_19990632_19990980 0.31 HTR6
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
974
0.53
chr1_40308777_40308928 0.31 ENSG00000202222
.
38498
0.09
chr4_39184616_39184822 0.31 WDR19
WD repeat domain 19
551
0.8
chr20_43996117_43996734 0.31 SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
4331
0.13
chr16_79321230_79321593 0.31 ENSG00000222244
.
23060
0.27
chr15_58776881_58777054 0.31 ALDH1A2
aldehyde dehydrogenase 1 family, member A2
10855
0.17
chr16_2732054_2732296 0.31 KCTD5
potassium channel tetramerization domain containing 5
301
0.81
chr6_112311435_112311966 0.30 WISP3
WNT1 inducible signaling pathway protein 3
63575
0.11
chr15_91143361_91143512 0.30 CTD-3065B20.2

3757
0.19
chr2_29236792_29237319 0.30 FAM179A
family with sequence similarity 179, member A
4072
0.19
chr9_15273609_15273760 0.30 TTC39B
tetratricopeptide repeat domain 39B
23570
0.22
chr1_114483670_114483821 0.30 HIPK1
homeodomain interacting protein kinase 1
10022
0.13
chr1_8489234_8489385 0.30 RP5-1115A15.1

3611
0.23
chr22_31635869_31636357 0.30 LIMK2
LIM domain kinase 2
8231
0.11
chr10_3823619_3823776 0.30 KLF6
Kruppel-like factor 6
3688
0.26
chrX_51546941_51547203 0.30 MAGED1
melanoma antigen family D, 1
969
0.65
chr1_154129901_154130138 0.29 NUP210L
nucleoporin 210kDa-like
2427
0.16
chr2_99075660_99075918 0.29 INPP4A
inositol polyphosphate-4-phosphatase, type I, 107kDa
14376
0.23
chr21_37442647_37442931 0.29 CBR1
carbonyl reductase 1
456
0.7
chr17_36125147_36125495 0.29 HNF1B
HNF1 homeobox B
20084
0.17
chr6_11232229_11232517 0.29 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
518
0.84
chr7_143007723_143007933 0.29 CLCN1
chloride channel, voltage-sensitive 1
5391
0.1
chr8_28917857_28918302 0.29 CTD-2647L4.4

4627
0.16
chr17_74994699_74995052 0.29 ENSG00000267568
.
29637
0.18
chr5_56029244_56029395 0.29 MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
82082
0.08
chr5_61595708_61595925 0.29 KIF2A
kinesin heavy chain member 2A
6173
0.29
chr1_117314006_117314157 0.29 CD2
CD2 molecule
16992
0.21
chr1_172674168_172674377 0.28 FASLG
Fas ligand (TNF superfamily, member 6)
46114
0.18
chr1_161101761_161102002 0.28 DEDD
death effector domain containing
375
0.66
chr6_149805531_149805682 0.28 ZC3H12D
zinc finger CCCH-type containing 12D
520
0.75
chr19_19144819_19144970 0.28 ARMC6
armadillo repeat containing 6
18
0.53
chr6_154549761_154549912 0.28 IPCEF1
interaction protein for cytohesin exchange factors 1
18154
0.29
chr1_226917633_226918259 0.28 ITPKB
inositol-trisphosphate 3-kinase B
7213
0.24
chr7_37397373_37397585 0.28 ELMO1
engulfment and cell motility 1
4207
0.24
chr8_8670148_8670299 0.28 MFHAS1
malignant fibrous histiocytoma amplified sequence 1
80932
0.08
chr2_98329502_98329955 0.28 ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
295
0.89
chr12_67910109_67910260 0.28 DYRK2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
131934
0.05
chr1_194195076_194195457 0.28 ENSG00000251813
.
262069
0.02
chr10_88853042_88853193 0.28 GLUD1
glutamate dehydrogenase 1
710
0.41
chr20_47355126_47355349 0.28 ENSG00000251876
.
748
0.78
chr3_30681139_30681293 0.28 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
33123
0.22
chr8_142114570_142114965 0.28 DENND3
DENN/MADD domain containing 3
12610
0.2
chr9_136542992_136543196 0.28 DBH-AS1
DBH antisense RNA 1
20659
0.14
chr5_72794880_72795057 0.28 BTF3
basic transcription factor 3
633
0.72
chrX_118809140_118809384 0.28 SEPT6
septin 6
17530
0.16
chr6_39193250_39193401 0.27 KCNK5
potassium channel, subfamily K, member 5
3901
0.31
chr1_212856444_212856782 0.27 ENSG00000207491
.
8993
0.16
chr14_104855656_104855812 0.27 ENSG00000222761
.
11651
0.26
chr14_91869680_91869962 0.27 CCDC88C
coiled-coil domain containing 88C
13869
0.23
chr16_89831901_89832100 0.27 FANCA
Fanconi anemia, complementation group A
20530
0.11
chr16_54317076_54317257 0.27 IRX3
iroquois homeobox 3
2601
0.34
chr11_46353424_46353814 0.27 DGKZ
diacylglycerol kinase, zeta
836
0.56
chrX_135226218_135226483 0.27 FHL1
four and a half LIM domains 1
3209
0.27
chr4_109057465_109057616 0.27 LEF1
lymphoid enhancer-binding factor 1
29917
0.19
chr1_28270612_28270863 0.27 SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
9116
0.12
chr6_166748574_166748725 0.27 SFT2D1
SFT2 domain containing 1
7430
0.19
chr12_111116625_111116776 0.27 HVCN1
hydrogen voltage-gated channel 1
9814
0.17
chr17_33755333_33755563 0.27 SLFN12
schlafen family member 12
4095
0.17
chr13_99864611_99864762 0.27 ENSG00000201793
.
6724
0.2
chr1_161158279_161158521 0.27 ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
10443
0.06
chr15_22541894_22542172 0.27 ENSG00000221641
.
28753
0.14
chr1_169667136_169667565 0.27 SELL
selectin L
13489
0.19
chr6_403561_403912 0.27 IRF4
interferon regulatory factor 4
11997
0.28
chr14_75714503_75714762 0.27 RP11-293M10.2

11482
0.15
chr7_157405170_157405445 0.27 AC005481.5
Uncharacterized protein
1408
0.48
chr2_198027116_198027292 0.27 ANKRD44
ankyrin repeat domain 44
14576
0.22
chr12_92499837_92499988 0.27 C12orf79
chromosome 12 open reading frame 79
30885
0.16
chr1_167452616_167452767 0.27 RP11-104L21.2

24793
0.17
chr1_12124513_12125028 0.27 TNFRSF8
tumor necrosis factor receptor superfamily, member 8
1243
0.37
chr15_61134389_61134543 0.27 RP11-554D20.1

77527
0.11
chr7_8188472_8188733 0.27 ENSG00000265212
.
6050
0.24
chr1_205780246_205780397 0.27 SLC41A1
solute carrier family 41 (magnesium transporter), member 1
1983
0.3
chr15_81616223_81616414 0.26 STARD5
StAR-related lipid transfer (START) domain containing 5
148
0.78
chr8_21917244_21917395 0.26 DMTN
dematin actin binding protein
585
0.63
chr7_150283340_150283491 0.26 GIMAP4
GTPase, IMAP family member 4
18891
0.17
chr1_37072853_37073004 0.26 CSF3R
colony stimulating factor 3 receptor (granulocyte)
124049
0.05
chr13_24848157_24848441 0.26 SPATA13
spermatogenesis associated 13
1472
0.37
chr4_103746866_103747017 0.26 UBE2D3
ubiquitin-conjugating enzyme E2D 3
1
0.97
chr5_89824965_89825116 0.26 GPR98
G protein-coupled receptor 98
121
0.77
chr10_134250626_134250777 0.26 RP11-432J24.3

4287
0.21
chr6_111417165_111417343 0.26 ENSG00000200926
.
4719
0.21
chr2_46771170_46771438 0.26 RHOQ
ras homolog family member Q
765
0.53
chr7_50465139_50465290 0.26 ENSG00000200815
.
37864
0.17
chr17_73284943_73285225 0.26 SLC25A19
solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
209
0.87
chr5_141339545_141339774 0.26 PCDH12
protocadherin 12
1032
0.38
chr13_41575756_41575909 0.26 ELF1
E74-like factor 1 (ets domain transcription factor)
17618
0.19
chr1_31451236_31451387 0.26 ENSG00000200181
.
10228
0.16
chr21_35009334_35009485 0.26 CRYZL1
crystallin, zeta (quinone reductase)-like 1
3401
0.21
chr18_68340939_68341090 0.26 GTSCR1
Gilles de la Tourette syndrome chromosome region, candidate 1
23034
0.28
chr7_27879709_27879984 0.26 TAX1BP1
Tax1 (human T-cell leukemia virus type I) binding protein 1
12426
0.23
chr18_55333585_55333751 0.26 ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
22232
0.15
chr4_147097308_147097459 0.26 LSM6
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
502
0.83
chr7_144517018_144517169 0.26 TPK1
thiamin pyrophosphokinase 1
16053
0.24
chr10_81009536_81009687 0.25 ZMIZ1
zinc finger, MIZ-type containing 1
56364
0.14
chr14_90081515_90082105 0.25 FOXN3
forkhead box N3
3664
0.17
chr10_28622609_28622843 0.25 MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
689
0.74
chr14_69862004_69862155 0.25 ERH
enhancer of rudimentary homolog (Drosophila)
2937
0.27
chr4_96212646_96212797 0.25 BMPR1B
bone morphogenetic protein receptor, type IB
187215
0.03
chr8_19526433_19526584 0.25 CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
13586
0.3
chr4_83292965_83293276 0.25 HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
1183
0.42
chrX_78213061_78213264 0.25 P2RY10
purinergic receptor P2Y, G-protein coupled, 10
12244
0.31
chr17_18805378_18805631 0.25 PRPSAP2
phosphoribosyl pyrophosphate synthetase-associated protein 2
8963
0.14
chr17_74268830_74269044 0.25 UBALD2
UBA-like domain containing 2
7153
0.13
chr19_7060314_7060465 0.25 MBD3L3
methyl-CpG binding domain protein 3-like 3
1738
0.24
chr20_45181136_45181287 0.25 OCSTAMP
osteoclast stimulatory transmembrane protein
1998
0.35
chr1_65420057_65420208 0.25 JAK1
Janus kinase 1
12055
0.24
chr3_182535868_182536019 0.25 ATP11B
ATPase, class VI, type 11B
18962
0.21
chr8_127514447_127514598 0.25 ENSG00000207138
.
2486
0.33
chr22_19492900_19493051 0.25 CLDN5
claudin 5
19931
0.11
chr1_32729687_32729990 0.25 LCK
lymphocyte-specific protein tyrosine kinase
9876
0.09
chr18_13415322_13415736 0.25 LDLRAD4-AS1
LDLRAD4 antisense RNA 1
11950
0.14
chr14_70092578_70092874 0.25 KIAA0247
KIAA0247
14413
0.23
chr19_52641838_52642032 0.25 ZNF616
zinc finger protein 616
143
0.93
chr1_28995908_28996059 0.25 GMEB1
glucocorticoid modulatory element binding protein 1
691
0.59
chr3_52739027_52739199 0.25 SPCS1
signal peptidase complex subunit 1 homolog (S. cerevisiae)
142
0.81
chr2_109580892_109581113 0.25 EDAR
ectodysplasin A receptor
24723
0.24
chr11_44799482_44799633 0.25 TSPAN18
tetraspanin 18
13581
0.28
chr9_119747863_119748014 0.25 ENSG00000265662
.
113348
0.07
chrX_118890897_118891053 0.25 SOWAHD
sosondowah ankyrin repeat domain family member D
1601
0.33
chrX_153577620_153577796 0.25 FLNA
filamin A, alpha
3829
0.12
chr13_100035601_100035752 0.25 ENSG00000207719
.
27291
0.18
chr14_100740094_100740249 0.25 RP11-638I2.2

10053
0.09
chr2_128051406_128051557 0.25 ERCC3
excision repair cross-complementing rodent repair deficiency, complementation group 3
189
0.95
chr17_17309326_17309550 0.25 ENSG00000201741
.
54320
0.1
chrX_75364693_75364987 0.25 PBDC1
polysaccharide biosynthesis domain containing 1
27931
0.25
chr5_154321291_154321511 0.25 MRPL22
mitochondrial ribosomal protein L22
739
0.64
chr1_46131645_46131796 0.24 GPBP1L1
GC-rich promoter binding protein 1-like 1
20488
0.13
chr1_66836150_66836429 0.24 PDE4B
phosphodiesterase 4B, cAMP-specific
16224
0.28
chrX_62973815_62974068 0.24 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
1047
0.62
chr17_72272476_72272627 0.24 DNAI2
dynein, axonemal, intermediate chain 2
2122
0.2
chr1_110449147_110449329 0.24 CSF1
colony stimulating factor 1 (macrophage)
3626
0.22
chr11_60793831_60793982 0.24 CD6
CD6 molecule
17900
0.14
chr17_76410012_76410244 0.24 PGS1
phosphatidylglycerophosphate synthase 1
10083
0.13
chr15_77295458_77295609 0.24 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
7618
0.2
chr6_131603664_131603895 0.24 AKAP7
A kinase (PRKA) anchor protein 7
32209
0.24
chr12_121902175_121902326 0.24 KDM2B
lysine (K)-specific demethylase 2B
45259
0.13
chr10_5749983_5750134 0.24 RP11-336A10.2

6328
0.18
chr9_99481734_99481900 0.24 ZNF510
zinc finger protein 510
58511
0.12
chr12_116538771_116538922 0.24 ENSG00000200665
.
18471
0.21
chr3_71447838_71447989 0.24 FOXP1
forkhead box P1
94002
0.08
chr11_12244895_12245157 0.24 RP11-265D17.2

39694
0.15
chr10_33622577_33623112 0.24 NRP1
neuropilin 1
466
0.87
chr6_5506877_5507119 0.24 RP1-232P20.1

48690
0.17
chr17_4248495_4248646 0.24 UBE2G1
ubiquitin-conjugating enzyme E2G 1
505
0.78
chrX_70317352_70317717 0.24 FOXO4
forkhead box O4
1155
0.33
chr2_122493823_122494052 0.24 NIFK
nucleolar protein interacting with the FHA domain of MKI67
550
0.55
chr2_102974093_102974405 0.24 IL18R1
interleukin 18 receptor 1
1860
0.33
chr21_36384069_36384311 0.24 RUNX1
runt-related transcription factor 1
37272
0.23

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of E2F8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.1 0.2 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.1 0.6 GO:0045059 positive thymic T cell selection(GO:0045059)
0.1 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.2 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.1 0.2 GO:0006154 adenosine catabolic process(GO:0006154)
0.1 0.2 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.1 0.3 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.3 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.1 0.2 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.1 0.3 GO:0019985 translesion synthesis(GO:0019985)
0.1 0.1 GO:1903224 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.1 0.2 GO:0032543 mitochondrial translation(GO:0032543)
0.1 0.4 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.1 0.1 GO:0002448 mast cell mediated immunity(GO:0002448)
0.1 0.3 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.1 0.2 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.1 0.1 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 0.2 GO:0015705 iodide transport(GO:0015705)
0.1 0.2 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.2 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.1 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) membrane raft localization(GO:0051665)
0.0 0.5 GO:0051319 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.1 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0 0.1 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.1 GO:0031223 auditory behavior(GO:0031223)
0.0 0.1 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.1 GO:0060677 ureteric bud elongation(GO:0060677)
0.0 0.2 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.2 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.3 GO:0032717 negative regulation of interleukin-8 production(GO:0032717)
0.0 0.1 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0046471 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.1 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 0.1 GO:0032776 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.3 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.0 0.1 GO:0043368 positive T cell selection(GO:0043368)
0.0 0.3 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.1 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.2 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.1 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.1 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.0 0.1 GO:0048840 otolith development(GO:0048840)
0.0 0.1 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.2 GO:0060023 soft palate development(GO:0060023)
0.0 0.1 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.1 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.3 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.3 GO:0033005 positive regulation of mast cell activation(GO:0033005)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.2 GO:0007097 nuclear migration(GO:0007097)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0002713 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0 0.1 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.3 GO:0006265 DNA topological change(GO:0006265)
0.0 0.1 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0 0.1 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.0 0.1 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.0 0.1 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.0 0.1 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.0 0.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.1 GO:0033084 regulation of immature T cell proliferation in thymus(GO:0033084) negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.0 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.3 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.1 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070)
0.0 0.1 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.2 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.0 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.0 0.1 GO:0015809 arginine transport(GO:0015809)
0.0 0.1 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.2 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.1 GO:0032025 response to cobalt ion(GO:0032025)
0.0 0.2 GO:0009070 serine family amino acid biosynthetic process(GO:0009070)
0.0 0.1 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.1 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.0 0.2 GO:0071548 response to dexamethasone(GO:0071548)
0.0 0.1 GO:0000042 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0 0.1 GO:0090322 regulation of superoxide metabolic process(GO:0090322)
0.0 0.3 GO:1901661 quinone metabolic process(GO:1901661)
0.0 0.6 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.0 GO:0071816 protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.0 GO:0052167 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0 0.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.0 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.2 GO:0006734 NADH metabolic process(GO:0006734)
0.0 0.1 GO:0031579 membrane raft organization(GO:0031579)
0.0 0.1 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.4 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.1 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.2 GO:0031648 protein destabilization(GO:0031648)
0.0 0.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0060263 regulation of respiratory burst(GO:0060263)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.0 GO:0048148 behavioral response to cocaine(GO:0048148)
0.0 0.1 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 0.1 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.0 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.1 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.0 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.1 GO:0060123 regulation of growth hormone secretion(GO:0060123)
0.0 0.2 GO:0043631 RNA polyadenylation(GO:0043631)
0.0 0.0 GO:0014805 smooth muscle adaptation(GO:0014805)
0.0 0.0 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.1 GO:0050860 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0002507 tolerance induction(GO:0002507)
0.0 0.2 GO:0097191 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) extrinsic apoptotic signaling pathway(GO:0097191)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.0 GO:0003161 cardiac conduction system development(GO:0003161)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.1 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.0 GO:0030202 heparin metabolic process(GO:0030202)
0.0 0.2 GO:0015669 gas transport(GO:0015669)
0.0 0.1 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.1 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.2 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.0 GO:1900120 regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0 0.1 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.0 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:0006000 fructose metabolic process(GO:0006000)
0.0 0.1 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 0.2 GO:0006862 nucleotide transport(GO:0006862)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.0 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0046874 quinolinate metabolic process(GO:0046874)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.0 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.0 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.0 GO:0042117 monocyte activation(GO:0042117)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.0 GO:0040023 establishment of nucleus localization(GO:0040023)
0.0 0.0 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.0 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.0 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.2 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0 0.0 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0 0.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.1 GO:0021707 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.3 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.0 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.0 GO:0000154 rRNA modification(GO:0000154)
0.0 0.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.0 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:0061515 erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0 0.1 GO:0042976 activation of Janus kinase activity(GO:0042976)
0.0 0.0 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.0 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
0.0 0.0 GO:0090286 nuclear matrix organization(GO:0043578) cytoskeletal anchoring at nuclear membrane(GO:0090286) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.2 GO:0045576 mast cell activation(GO:0045576)
0.0 0.3 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0 0.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.1 GO:0042508 tyrosine phosphorylation of Stat1 protein(GO:0042508)
0.0 0.1 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.0 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.0 GO:0018126 protein hydroxylation(GO:0018126)
0.0 0.0 GO:1901021 positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of cation channel activity(GO:2001259)
0.0 0.0 GO:0051294 establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0 0.0 GO:0045759 negative regulation of action potential(GO:0045759)
0.0 0.1 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.0 GO:0002478 antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546)
0.0 0.1 GO:0042130 negative regulation of T cell proliferation(GO:0042130)
0.0 0.0 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.0 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.0 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.0 GO:0071698 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.0 GO:0002691 regulation of cellular extravasation(GO:0002691)
0.0 0.0 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 0.1 GO:0018065 protein-cofactor linkage(GO:0018065)
0.0 0.1 GO:0032392 DNA geometric change(GO:0032392)
0.0 0.0 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.0 GO:0052251 induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0 0.2 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.0 GO:0003197 endocardial cushion development(GO:0003197)
0.0 0.0 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0 0.1 GO:0032727 positive regulation of interferon-alpha production(GO:0032727)
0.0 0.1 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.1 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.0 GO:0006678 glucosylceramide metabolic process(GO:0006678)
0.0 0.0 GO:0019530 taurine metabolic process(GO:0019530)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0001510 RNA methylation(GO:0001510)
0.0 0.0 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.1 GO:0051383 kinetochore organization(GO:0051383)
0.0 0.0 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.0 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0006573 valine metabolic process(GO:0006573)
0.0 0.0 GO:0090399 replicative senescence(GO:0090399)
0.0 0.1 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 0.0 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.0 GO:0002740 negative regulation of cytokine secretion involved in immune response(GO:0002740)
0.0 0.0 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.1 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.1 GO:0034375 high-density lipoprotein particle remodeling(GO:0034375)
0.0 0.0 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.1 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.0 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.0 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.0 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664)
0.0 0.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.0 GO:2000143 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.0 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0 0.0 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.2 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.0 0.1 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.1 GO:0034331 cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0 0.2 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.1 GO:0016556 mRNA modification(GO:0016556)
0.0 0.1 GO:0030838 positive regulation of actin filament polymerization(GO:0030838)
0.0 0.2 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.0 GO:0031058 positive regulation of histone modification(GO:0031058)
0.0 0.1 GO:0016180 snRNA processing(GO:0016180)
0.0 0.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.0 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.1 GO:0001776 leukocyte homeostasis(GO:0001776)
0.0 0.1 GO:0030858 positive regulation of epithelial cell differentiation(GO:0030858)
0.0 0.0 GO:1901419 regulation of response to alcohol(GO:1901419)
0.0 0.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.0 GO:0071504 cellular response to heparin(GO:0071504)
0.0 0.1 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.1 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.0 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.1 GO:0019059 obsolete initiation of viral infection(GO:0019059)
0.0 0.0 GO:0002138 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0 0.1 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.0 GO:0046618 drug export(GO:0046618)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0000090 mitotic anaphase(GO:0000090)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.2 GO:0019433 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 0.1 GO:0033687 osteoblast proliferation(GO:0033687)
0.0 0.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.1 GO:0032400 melanosome localization(GO:0032400)
0.0 0.0 GO:0048087 positive regulation of developmental pigmentation(GO:0048087)
0.0 0.0 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.0 GO:0035269 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0 0.0 GO:0007090 obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0 0.2 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.2 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 0.1 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.0 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.3 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.0 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.0 GO:0051095 regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.0 0.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.1 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.0 GO:0015825 L-serine transport(GO:0015825)
0.0 0.2 GO:0048255 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0 0.0 GO:0050932 regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0 0.3 GO:0050772 positive regulation of axonogenesis(GO:0050772)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.2 GO:0002139 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.1 0.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.1 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.3 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.0 GO:0070552 BRISC complex(GO:0070552)
0.0 0.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.1 GO:0000791 euchromatin(GO:0000791)
0.0 0.1 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.1 GO:1903561 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.5 GO:0005626 obsolete insoluble fraction(GO:0005626)
0.0 0.0 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.1 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.2 GO:0071565 nBAF complex(GO:0071565)
0.0 0.3 GO:0005844 polysome(GO:0005844)
0.0 0.3 GO:0030530 obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0 0.2 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.0 0.0 GO:0032009 early phagosome(GO:0032009)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:0071203 WASH complex(GO:0071203)
0.0 0.1 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.0 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.1 GO:0001741 XY body(GO:0001741)
0.0 0.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.1 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.0 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.0 GO:0072487 MSL complex(GO:0072487)
0.0 0.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.2 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.1 GO:0032156 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.0 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.3 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.1 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.0 GO:0042827 platelet dense granule(GO:0042827)
0.0 0.0 GO:0031501 mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0016592 mediator complex(GO:0016592)
0.0 0.0 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.1 0.2 GO:0032554 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.1 0.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 0.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.1 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.5 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.2 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.7 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.3 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.1 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.1 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.1 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.1 GO:0004083 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.1 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0019863 IgE binding(GO:0019863)
0.0 0.1 GO:0071723 lipopeptide binding(GO:0071723)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0004739 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.2 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.5 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0016208 AMP binding(GO:0016208)
0.0 0.0 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0 0.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.2 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 0.2 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.1 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.1 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0003701 obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0 0.1 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.1 GO:0004428 obsolete inositol or phosphatidylinositol kinase activity(GO:0004428)
0.0 0.3 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.3 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.2 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.1 GO:0048156 tau protein binding(GO:0048156)
0.0 0.3 GO:0043022 ribosome binding(GO:0043022)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.2 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.1 GO:0031177 phosphopantetheine binding(GO:0031177)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.0 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.0 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.0 0.1 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.1 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.5 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.2 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.1 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.1 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.0 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.0 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.0 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.0 GO:0034618 nitric-oxide synthase activity(GO:0004517) arginine binding(GO:0034618)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.0 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.0 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.1 GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.0 GO:0035197 siRNA binding(GO:0035197)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.0 GO:0052659 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.0 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.0 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.0 0.0 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.0 GO:0070061 fructose binding(GO:0070061)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.0 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.0 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.0 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.8 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.1 GO:0015520 tetracycline:proton antiporter activity(GO:0015520)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.0 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.3 GO:0017022 myosin binding(GO:0017022)
0.0 0.0 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.2 GO:0043621 protein self-association(GO:0043621)
0.0 0.0 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.0 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.0 0.0 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.3 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.1 GO:0051635 obsolete bacterial cell surface binding(GO:0051635)
0.0 0.2 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 0.2 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.0 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.0 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.1 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.0 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.0 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.0 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.0 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.7 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.0 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.7 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.1 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.1 PID AURORA A PATHWAY Aurora A signaling
0.0 0.3 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.1 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.1 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.6 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.2 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.0 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.3 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.2 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.2 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.2 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.1 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.1 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.0 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.2 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.1 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.2 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.2 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.1 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.1 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.2 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.1 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.1 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 0.1 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.6 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.5 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.4 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.1 REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.1 REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK
0.0 0.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.0 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.0 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.3 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.3 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.0 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.5 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.0 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.3 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.0 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.1 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.2 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.2 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.1 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.1 REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 0.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.0 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.0 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.2 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.1 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.2 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.1 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi