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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for EN2_GBX2_LBX2

Z-value: 0.41

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Transcription factors associated with EN2_GBX2_LBX2

Gene Symbol	Gene ID	Gene Info
EN2 Ensembl NCBI GeneCards UniProt	ENSG00000164778.4	engrailed homeobox 2
GBX2 Ensembl NCBI GeneCards UniProt	ENSG00000168505.6	gastrulation brain homeobox 2
LBX2 Ensembl NCBI GeneCards UniProt	ENSG00000179528.11	ladybird homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr7_155258168_155258329	EN2	7424	0.202726	0.80	9.7e-03	Click!
chr7_155257936_155258087	EN2	7187	0.203781	0.64	6.1e-02	Click!
chr7_155252800_155252951	EN2	2051	0.330679	0.57	1.1e-01	Click!
chr7_155260657_155261013	EN2	10011	0.194120	0.51	1.6e-01	Click!
chr7_155264148_155264299	EN2	13399	0.185836	-0.45	2.3e-01	Click!
chr2_237088836_237088987	GBX2	11899	0.144788	-0.60	8.7e-02	Click!
chr2_237088666_237088817	GBX2	11729	0.145069	-0.60	9.0e-02	Click!
chr2_237081005_237081156	GBX2	4068	0.175730	0.45	2.2e-01	Click!
chr2_237077629_237077780	GBX2	692	0.570341	-0.38	3.2e-01	Click!
chr2_237087329_237087480	GBX2	10392	0.147383	0.33	3.8e-01	Click!
chr2_74726899_74727050	LBX2	131	0.757860	0.58	1.0e-01	Click!
chr2_74731286_74731437	LBX2	918	0.240961	-0.51	1.7e-01	Click!
chr2_74727069_74727321	LBX2	352	0.531282	-0.44	2.4e-01	Click!
chr2_74732516_74733402	LBX2	2516	0.086291	-0.40	2.8e-01	Click!
chr2_74732343_74732494	LBX2	1975	0.105454	-0.40	2.9e-01	Click!

Activity of the EN2_GBX2_LBX2 motif across conditions

Conditions sorted by the z-value of the EN2_GBX2_LBX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_101394347_101394839	0.23	SLC30A7	solute carrier family 30 (zinc transporter), member 7	32783	0.12
chr21_26937814_26938070	0.21	ENSG00000234883	.	8350	0.19
chr16_73092870_73093114	0.20	ZFHX3	zinc finger homeobox 3	605	0.79
chr8_49862673_49862887	0.20	SNAI2	snail family zinc finger 2	28481	0.25
chr9_117142014_117142165	0.19	AKNA	AT-hook transcription factor	2174	0.33
chr13_46893880_46894070	0.18	ENSG00000223336	.	54750	0.1
chr1_169672251_169672700	0.17	SELL	selectin L	8364	0.2
chr3_186237166_186237573	0.16	CRYGS	crystallin, gamma S	24871	0.16
chr6_74169990_74170157	0.16	MTO1	mitochondrial tRNA translation optimization 1	1228	0.27
chr5_100190438_100190674	0.16	ENSG00000221263	.	38287	0.19
chr1_172666866_172667065	0.15	FASLG	Fas ligand (TNF superfamily, member 6)	38807	0.19
chr21_36305039_36305387	0.15	RUNX1	runt-related transcription factor 1	43126	0.21
chr15_39915311_39915462	0.15	FSIP1	fibrous sheath interacting protein 1	22259	0.18
chr2_30557961_30558163	0.15	ENSG00000221377	.	97252	0.07
chr2_198100640_198101238	0.15	ANKRD44	ankyrin repeat domain 44	38177	0.14
chr12_68382310_68382485	0.15	IFNG-AS1	IFNG antisense RNA 1	828	0.76
chr18_77128932_77129101	0.15	RP11-800A18.4		25044	0.17
chr19_47948776_47948927	0.14	MEIS3	Meis homeobox 3	26071	0.11
chr22_39714814_39715056	0.14	RPL3	ribosomal protein L3	181	0.48
chr10_11201909_11202161	0.14	CELF2	CUGBP, Elav-like family member 2	4958	0.24
chr10_11248462_11248734	0.14	RP3-323N1.2		35259	0.18
chr16_74620197_74620348	0.13	GLG1	golgi glycoprotein 1	20720	0.2
chr5_76939960_76940111	0.13	OTP	orthopedia homeobox	4522	0.27
chr3_16883717_16883868	0.13	PLCL2	phospholipase C-like 2	42660	0.19
chr5_133425812_133426164	0.13	TCF7	transcription factor 7 (T-cell specific, HMG-box)	24414	0.2
chr4_109037661_109037882	0.13	LEF1	lymphoid enhancer-binding factor 1	49686	0.14
chr1_3806778_3806979	0.13	ENSG00000264428	.	6250	0.16
chr7_142024322_142024543	0.12	PRSS3P3	protease, serine, 3 pseudogene 3	34823	0.18
chr2_204726088_204726239	0.12	CTLA4	cytotoxic T-lymphocyte-associated protein 4	6346	0.27
chr17_38376031_38376425	0.12	WIPF2	WAS/WASL interacting protein family, member 2	124	0.95
chr11_6425333_6425495	0.12	APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	480	0.74
chr2_197039401_197039716	0.12	STK17B	serine/threonine kinase 17b	1493	0.42
chr3_71516692_71516843	0.12	ENSG00000221264	.	74473	0.1
chr3_16971345_16971496	0.12	PLCL2	phospholipase C-like 2	3162	0.28
chr3_32376993_32377254	0.12	CMTM7	CKLF-like MARVEL transmembrane domain containing 7	56040	0.12
chrX_118821503_118821974	0.12	SEPT6	septin 6	5054	0.2
chr9_95786987_95787346	0.12	FGD3	FYVE, RhoGEF and PH domain containing 3	9824	0.19
chr17_71199413_71199564	0.12	COG1	component of oligomeric golgi complex 1	2266	0.24
chrX_117644955_117645193	0.12	DOCK11	dedicator of cytokinesis 11	15202	0.24
chr7_100140293_100140446	0.12	AGFG2	ArfGAP with FG repeats 2	3487	0.11
chr15_70554588_70554739	0.11	ENSG00000200216	.	69088	0.13
chr3_43064995_43065183	0.11	FAM198A	family with sequence similarity 198, member A	44049	0.13
chr13_108979091_108979372	0.11	ENSG00000223177	.	25552	0.22
chr20_47334105_47334366	0.11	ENSG00000251876	.	21750	0.26
chr16_16193929_16194080	0.11	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	90291	0.07
chr2_18003162_18003313	0.11	MSGN1	mesogenin 1	5474	0.22
chr5_109032486_109032637	0.11	ENSG00000202512	.	2974	0.27
chr12_68530648_68530810	0.11	IFNG	interferon, gamma	22798	0.24
chr6_139616194_139616345	0.11	TXLNB	taxilin beta	2993	0.28
chr13_20985266_20985502	0.11	ENSG00000263978	.	22601	0.23
chr11_128589269_128589420	0.11	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	23426	0.17
chr1_41810525_41810676	0.11	FOXO6	forkhead box O6	16994	0.21
chr17_17084049_17084292	0.11	MPRIP	myosin phosphatase Rho interacting protein	1298	0.29
chr6_15078179_15078392	0.11	ENSG00000242989	.	34914	0.21
chr10_111845210_111845446	0.11	ADD3	adducin 3 (gamma)	77606	0.09
chr18_5158274_5158519	0.11	C18orf42	chromosome 18 open reading frame 42	38828	0.21
chr1_200987046_200987749	0.11	KIF21B	kinesin family member 21B	5139	0.21
chr11_64541210_64541478	0.11	SF1	splicing factor 1	3888	0.14
chr9_36218264_36218537	0.11	CLTA	clathrin, light chain A	27440	0.14
chr5_133881433_133881702	0.11	JADE2	jade family PHD finger 2	19240	0.15
chr8_52913099_52913333	0.11	RP11-110G21.1		100922	0.07
chr20_31116051_31116202	0.11	C20orf112	chromosome 20 open reading frame 112	7469	0.18
chr2_8615200_8615353	0.11	AC011747.7		200620	0.03
chr13_51487581_51487732	0.10	RNASEH2B-AS1	RNASEH2B antisense RNA 1	2808	0.26
chr13_32998493_32998691	0.10	N4BP2L1	NEDD4 binding protein 2-like 1	3559	0.24
chr3_81913343_81913495	0.10	GBE1	glucan (1,4-alpha-), branching enzyme 1	102107	0.09
chr2_111506043_111506194	0.10	ACOXL	acyl-CoA oxidase-like	15686	0.25
chr17_47872989_47873209	0.10	KAT7	K(lysine) acetyltransferase 7	6084	0.16
chr14_93315070_93315221	0.10	GOLGA5	golgin A5	15674	0.24
chr1_60036490_60036813	0.10	FGGY	FGGY carbohydrate kinase domain containing	17061	0.29
chr12_93827062_93827301	0.10	UBE2N	ubiquitin-conjugating enzyme E2N	7851	0.16
chr2_182171124_182171288	0.10	ENSG00000266705	.	827	0.77
chr17_42579880_42580174	0.10	GPATCH8	G patch domain containing 8	732	0.66
chr1_235439552_235439703	0.10	GGPS1	geranylgeranyl diphosphate synthase 1	51038	0.11
chr12_2472562_2472713	0.10	CACNA1C-IT3	CACNA1C intronic transcript 3 (non-protein coding)	93695	0.08
chr10_61631584_61631735	0.10	CCDC6	coiled-coil domain containing 6	34755	0.21
chr4_140971490_140971641	0.10	RP11-392B6.1		77604	0.1
chr14_66460757_66460908	0.10	CTD-2014B16.3	Uncharacterized protein	10409	0.25
chr3_135908620_135908771	0.10	MSL2	male-specific lethal 2 homolog (Drosophila)	4701	0.3
chr15_52338744_52338984	0.10	RP11-430B1.1		12960	0.15
chr13_113840073_113840224	0.10	RP11-98F14.11		20651	0.11
chr12_89632258_89632472	0.10	ENSG00000238302	.	43697	0.19
chr8_66873049_66873243	0.10	DNAJC5B	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	60649	0.14
chr18_11852927_11853152	0.10	RP11-78A19.3		289	0.82
chr2_144014874_144015136	0.10	RP11-190J23.1		85264	0.1
chr1_211913474_211913689	0.10	ENSG00000241395	.	52167	0.1
chr3_128836654_128836805	0.10	RAB43	RAB43, member RAS oncogene family	3895	0.15
chr17_40574094_40574415	0.10	PTRF	polymerase I and transcript release factor	1281	0.3
chr14_66304578_66304729	0.10	CTD-2014B16.3	Uncharacterized protein	166588	0.04
chr2_26018392_26018619	0.10	ASXL2	additional sex combs like 2 (Drosophila)	15327	0.23
chr20_44634089_44634268	0.10	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	3369	0.16
chr6_11276274_11276599	0.10	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	43521	0.17
chr1_100905257_100905795	0.10	RP5-837M10.4		46027	0.13
chr12_27107136_27107312	0.09	FGFR1OP2	FGFR1 oncogene partner 2	15791	0.13
chr1_235438349_235438790	0.09	GGPS1	geranylgeranyl diphosphate synthase 1	52096	0.11
chr19_8639084_8639286	0.09	MYO1F	myosin IF	3137	0.16
chr1_166133959_166134203	0.09	RP11-9L18.3		251	0.9
chr3_151932265_151932416	0.09	MBNL1	muscleblind-like splicing regulator 1	53489	0.14
chr16_79652126_79652340	0.09	MAF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog	17622	0.26
chr14_50530285_50530492	0.09	ENSG00000201358	.	4898	0.18
chr6_167550535_167550692	0.09	TCP10L2	t-complex 10-like 2	12355	0.17
chrX_70325744_70326037	0.09	CXorf65	chromosome X open reading frame 65	565	0.6
chr9_70851374_70851561	0.09	CBWD3	COBW domain containing 3	4930	0.19
chr11_118097693_118098499	0.09	AMICA1	adhesion molecule, interacts with CXADR antigen 1	2287	0.23
chr5_169708109_169708260	0.09	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	13853	0.22
chr10_121543359_121543582	0.09	INPP5F	inositol polyphosphate-5-phosphatase F	2331	0.32
chr9_92078215_92078535	0.09	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	7507	0.25
chr9_71633765_71634208	0.09	PRKACG	protein kinase, cAMP-dependent, catalytic, gamma	4947	0.24
chr6_42740405_42740590	0.09	GLTSCR1L	GLTSCR1-like	9268	0.17
chr1_193428730_193429035	0.09	ENSG00000252241	.	272192	0.01
chr5_61873952_61874158	0.09	LRRC70	leucine rich repeat containing 70	507	0.52
chr8_29945094_29945295	0.09	TMEM66	transmembrane protein 66	4471	0.16
chr1_173487659_173487906	0.09	RP3-436N22.3		36608	0.14
chr7_21469388_21469667	0.09	SP4	Sp4 transcription factor	1866	0.34
chr22_21922789_21923120	0.09	UBE2L3	ubiquitin-conjugating enzyme E2L 3	928	0.38
chr12_111613238_111613505	0.09	CUX2	cut-like homeobox 2	76121	0.1
chr20_57723034_57723340	0.09	ZNF831	zinc finger protein 831	42888	0.16
chr1_42123736_42123959	0.09	HIVEP3	human immunodeficiency virus type I enhancer binding protein 3	42825	0.18
chr2_198072900_198073187	0.09	ANKRD44	ankyrin repeat domain 44	10281	0.21
chr16_3058535_3058724	0.09	LA16c-380H5.2		3527	0.07
chr1_42273293_42273444	0.09	ENSG00000264896	.	48556	0.18
chr6_42740244_42740405	0.09	GLTSCR1L	GLTSCR1-like	9441	0.17
chr3_98273092_98273322	0.09	GPR15	G protein-coupled receptor 15	22464	0.13
chr6_42409736_42409944	0.09	TRERF1	transcriptional regulating factor 1	9159	0.21
chr1_235587141_235587347	0.09	TBCE-AS1	TBCE antisense RNA 1	3054	0.29
chr16_3125440_3125843	0.09	ENSG00000252561	.	6117	0.06
chr1_151869347_151869629	0.09	THEM4	thioesterase superfamily member 4	12625	0.12
chr2_198057877_198058189	0.09	AC013264.2		4682	0.23
chrX_149646217_149646416	0.09	MAMLD1	mastermind-like domain containing 1	7036	0.24
chr1_158788831_158789034	0.09	MNDA	myeloid cell nuclear differentiation antigen	12175	0.17
chr8_103117650_103117985	0.09	NCALD	neurocalcin delta	18361	0.2
chr9_135382524_135382903	0.09	BARHL1	BarH-like homeobox 1	74859	0.09
chr19_47438297_47438633	0.09	ENSG00000252071	.	13081	0.16
chr22_36550343_36550563	0.09	APOL3	apolipoprotein L, 3	6378	0.24
chr11_20179253_20179404	0.09	DBX1	developing brain homeobox 1	2542	0.34
chr7_25560467_25560618	0.09	ENSG00000222101	.	49746	0.19
chr5_75600048_75600202	0.09	RP11-466P24.6		7162	0.3
chr2_114189862_114190032	0.09	CBWD2	COBW domain containing 2	5321	0.16
chr1_110333910_110334183	0.09	EPS8L3	EPS8-like 3	27397	0.13
chr7_143007723_143007933	0.09	CLCN1	chloride channel, voltage-sensitive 1	5391	0.1
chr5_67552449_67552681	0.09	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	16839	0.26
chr18_56438172_56438323	0.08	RP11-126O1.4		18285	0.15
chr19_5906272_5906423	0.08	VMAC	vimentin-type intermediate filament associated coiled-coil protein	1478	0.18
chr5_179433301_179433452	0.08	ENSG00000198995	.	9021	0.19
chr1_42267028_42267179	0.08	ENSG00000264896	.	42291	0.19
chr4_140724600_140724880	0.08	ENSG00000252233	.	9153	0.26
chr19_19185104_19185255	0.08	SLC25A42	solute carrier family 25, member 42	10371	0.13
chr15_40342145_40342411	0.08	SRP14	signal recognition particle 14kDa (homologous Alu RNA binding protein)	10889	0.15
chr21_36367069_36367374	0.08	RUNX1	runt-related transcription factor 1	54241	0.18
chr20_50077608_50077759	0.08	ENSG00000266761	.	8169	0.27
chr19_41811849_41812000	0.08	CCDC97	coiled-coil domain containing 97	4170	0.13
chr18_43266469_43266620	0.08	SLC14A2	solute carrier family 14 (urea transporter), member 2	20437	0.17
chrX_42259008_42259366	0.08	ENSG00000206896	.	225549	0.02
chr22_26988789_26989025	0.08	TPST2	tyrosylprotein sulfotransferase 2	2780	0.23
chr8_56756381_56756653	0.08	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	35855	0.12
chr12_2349139_2349290	0.08	CACNA1C-AS4	CACNA1C antisense RNA 4	16569	0.22
chr12_104865091_104865422	0.08	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	14477	0.26
chr14_60761646_60761856	0.08	PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A	38271	0.17
chr1_117058467_117058618	0.08	CD58	CD58 molecule	28670	0.15
chr10_49719976_49720127	0.08	ARHGAP22-IT1	ARHGAP22 intronic transcript 1 (non-protein coding)	419	0.87
chr3_107820810_107821187	0.08	CD47	CD47 molecule	11126	0.3
chr5_118710365_118710516	0.08	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	18710	0.2
chr2_37192955_37193106	0.08	STRN	striatin, calmodulin binding protein	576	0.74
chr7_135623902_135624121	0.08	LUZP6	leucine zipper protein 6	11813	0.14
chr4_89526439_89526704	0.08	HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	374	0.86
chr1_26441433_26441584	0.08	PDIK1L	PDLIM1 interacting kinase 1 like	3168	0.15
chr11_72866229_72866512	0.08	FCHSD2	FCH and double SH3 domains 2	13064	0.2
chr7_21004042_21004193	0.08	SP8	Sp8 transcription factor	177612	0.03
chr5_96345721_96346249	0.08	ENSG00000200884	.	47524	0.12
chr10_90144841_90145001	0.08	RNLS	renalase, FAD-dependent amine oxidase	198026	0.02
chr7_102072492_102072712	0.08	ORAI2	ORAI calcium release-activated calcium modulator 2	951	0.34
chr10_6642170_6642420	0.08	PRKCQ	protein kinase C, theta	20032	0.28
chr6_108139065_108139216	0.08	SCML4	sex comb on midleg-like 4 (Drosophila)	6376	0.29
chr1_28526158_28526348	0.08	AL353354.2		817	0.34
chr6_13686993_13687323	0.08	RANBP9	RAN binding protein 9	22	0.98
chr6_122733810_122733961	0.08	HSF2	heat shock transcription factor 2	9416	0.25
chr4_42634615_42634846	0.08	ATP8A1	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	24380	0.21
chr9_92022718_92022899	0.08	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	1967	0.41
chr2_143885609_143886070	0.08	ARHGAP15	Rho GTPase activating protein 15	1044	0.64
chr2_143914477_143914920	0.08	RP11-190J23.1		15043	0.24
chr10_11155205_11156000	0.08	CELF2-AS2	CELF2 antisense RNA 2	15166	0.21
chr9_70495481_70495632	0.08	CBWD5	COBW domain containing 5	5310	0.29
chr1_108624991_108625142	0.08	ENSG00000264753	.	63673	0.12
chr8_19552777_19552928	0.08	CSGALNACT1	chondroitin sulfate N-acetylgalactosaminyltransferase 1	12580	0.3
chr11_128348480_128348737	0.08	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	26681	0.22
chr22_40322800_40322970	0.08	GRAP2	GRB2-related adaptor protein 2	244	0.92
chr12_55372614_55372982	0.08	TESPA1	thymocyte expressed, positive selection associated 1	2824	0.31
chr16_50802191_50802342	0.08	CYLD	cylindromatosis (turban tumor syndrome)	18806	0.11
chr12_47600641_47601211	0.08	PCED1B	PC-esterase domain containing 1B	9126	0.22
chr11_13944070_13944221	0.08	ENSG00000201856	.	15008	0.29
chr8_59478164_59478344	0.08	SDCBP	syndecan binding protein (syntenin)	679	0.77
chrX_102787503_102787654	0.08	RAB40A	RAB40A, member RAS oncogene family	13161	0.15
chr16_85971060_85971235	0.08	IRF8	interferon regulatory factor 8	23228	0.22
chr1_89992034_89992185	0.08	LRRC8B	leucine rich repeat containing 8 family, member B	1647	0.46
chr12_21766880_21767202	0.08	GYS2	glycogen synthase 2 (liver)	9260	0.2
chr3_33102387_33102538	0.08	GLB1	galactosidase, beta 1	35822	0.13
chrX_19766831_19767108	0.08	SH3KBP1	SH3-domain kinase binding protein 1	1148	0.65
chr2_182100905_182101073	0.08	ENSG00000266705	.	69390	0.13
chr11_64537353_64537738	0.08	SF1	splicing factor 1	1002	0.4
chr10_6096471_6096850	0.08	IL2RA	interleukin 2 receptor, alpha	7593	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.2	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.0	GO:0046136	positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0097300	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.0	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.0	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0030910	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.0	GO:1901985	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.0	GO:0071224	cellular response to peptidoglycan(GO:0071224)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.0	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.0	GO:0045586	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.0	0.0	GO:0051532	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.0	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.1	GO:0006911	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.0	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.0	GO:0001714	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.0	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.0	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.0	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.0	0.0	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.0	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.0	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0002666	T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.0	0.1	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.0	GO:0002691	regulation of cellular extravasation(GO:0002691)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.0	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.0	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.0	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.2	GO:0001891	phagocytic cup(GO:0001891)
0.1	GO:0072487	MSL complex(GO:0072487)
0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	GO:0042584	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	GO:0033691	sialic acid binding(GO:0033691)
0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.0	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2	GO:0004697	protein kinase C activity(GO:0004697)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.4	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.2	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.5	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.3	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.2	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.2	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse

Results for EN2_GBX2_LBX2

Z-value: 0.41

Motif logo

Transcription factors associated with EN2_GBX2_LBX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the EN2_GBX2_LBX2 motif across conditions

Conditions sorted by the z-value of the EN2_GBX2_LBX2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: