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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for EN2_GBX2_LBX2

Z-value: 0.41

Motif logo

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Transcription factors associated with EN2_GBX2_LBX2

Gene Symbol Gene ID Gene Info
EN2
ENSG00000164778.4 EN2
GBX2
ENSG00000168505.6 GBX2
LBX2
ENSG00000179528.11 LBX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
EN2chr7_155258168_15525832974240.2027260.809.7e-03Click!
EN2chr7_155257936_15525808771870.2037810.646.1e-02Click!
EN2chr7_155252800_15525295120510.3306790.571.1e-01Click!
EN2chr7_155260657_155261013100110.1941200.511.6e-01Click!
EN2chr7_155264148_155264299133990.185836-0.452.3e-01Click!
GBX2chr2_237088836_237088987118990.144788-0.608.7e-02Click!
GBX2chr2_237088666_237088817117290.145069-0.609.0e-02Click!
GBX2chr2_237081005_23708115640680.1757300.452.2e-01Click!
GBX2chr2_237077629_2370777806920.570341-0.383.2e-01Click!
GBX2chr2_237087329_237087480103920.1473830.333.8e-01Click!
LBX2chr2_74726899_747270501310.7578600.581.0e-01Click!
LBX2chr2_74731286_747314379180.240961-0.511.7e-01Click!
LBX2chr2_74727069_747273213520.531282-0.442.4e-01Click!
LBX2chr2_74732516_7473340225160.086291-0.402.8e-01Click!
LBX2chr2_74732343_7473249419750.105454-0.402.9e-01Click!

Activity of the EN2_GBX2_LBX2 motif across conditions

Conditions sorted by the z-value of the EN2_GBX2_LBX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_101394347_101394839 0.23 SLC30A7
 solute carrier family 30 (zinc transporter), member 7
 32783
 0.12
chr21_26937814_26938070 0.21 ENSG00000234883
 .
 8350
 0.19
chr16_73092870_73093114 0.20 ZFHX3
 zinc finger homeobox 3
 605
 0.79
chr8_49862673_49862887 0.20 SNAI2
 snail family zinc finger 2
 28481
 0.25
chr9_117142014_117142165 0.19 AKNA
 AT-hook transcription factor
 2174
 0.33
chr13_46893880_46894070 0.18 ENSG00000223336
 .
 54750
 0.1
chr1_169672251_169672700 0.17 SELL
 selectin L
 8364
 0.2
chr3_186237166_186237573 0.16 CRYGS
 crystallin, gamma S
 24871
 0.16
chr6_74169990_74170157 0.16 MTO1
 mitochondrial tRNA translation optimization 1
 1228
 0.27
chr5_100190438_100190674 0.16 ENSG00000221263
 .
 38287
 0.19
chr1_172666866_172667065 0.15 FASLG
 Fas ligand (TNF superfamily, member 6)
 38807
 0.19
chr21_36305039_36305387 0.15 RUNX1
 runt-related transcription factor 1
 43126
 0.21
chr15_39915311_39915462 0.15 FSIP1
 fibrous sheath interacting protein 1
 22259
 0.18
chr2_30557961_30558163 0.15 ENSG00000221377
 .
 97252
 0.07
chr2_198100640_198101238 0.15 ANKRD44
 ankyrin repeat domain 44
 38177
 0.14
chr12_68382310_68382485 0.15 IFNG-AS1
 IFNG antisense RNA 1
 828
 0.76
chr18_77128932_77129101 0.15 RP11-800A18.4
25044
 0.17
chr19_47948776_47948927 0.14 MEIS3
 Meis homeobox 3
 26071
 0.11
chr22_39714814_39715056 0.14 RPL3
 ribosomal protein L3
 181
 0.48
chr10_11201909_11202161 0.14 CELF2
 CUGBP, Elav-like family member 2
 4958
 0.24
chr10_11248462_11248734 0.14 RP3-323N1.2
35259
 0.18
chr16_74620197_74620348 0.13 GLG1
 golgi glycoprotein 1
 20720
 0.2
chr5_76939960_76940111 0.13 OTP
 orthopedia homeobox
 4522
 0.27
chr3_16883717_16883868 0.13 PLCL2
 phospholipase C-like 2
 42660
 0.19
chr5_133425812_133426164 0.13 TCF7
 transcription factor 7 (T-cell specific, HMG-box)
 24414
 0.2
chr4_109037661_109037882 0.13 LEF1
 lymphoid enhancer-binding factor 1
 49686
 0.14
chr1_3806778_3806979 0.13 ENSG00000264428
 .
 6250
 0.16
chr7_142024322_142024543 0.12 PRSS3P3
 protease, serine, 3 pseudogene 3
 34823
 0.18
chr2_204726088_204726239 0.12 CTLA4
 cytotoxic T-lymphocyte-associated protein 4
 6346
 0.27
chr17_38376031_38376425 0.12 WIPF2
 WAS/WASL interacting protein family, member 2
 124
 0.95
chr11_6425333_6425495 0.12 APBB1
 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
 480
 0.74
chr2_197039401_197039716 0.12 STK17B
 serine/threonine kinase 17b
 1493
 0.42
chr3_71516692_71516843 0.12 ENSG00000221264
 .
 74473
 0.1
chr3_16971345_16971496 0.12 PLCL2
 phospholipase C-like 2
 3162
 0.28
chr3_32376993_32377254 0.12 CMTM7
 CKLF-like MARVEL transmembrane domain containing 7
 56040
 0.12
chrX_118821503_118821974 0.12 SEPT6
 septin 6
 5054
 0.2
chr9_95786987_95787346 0.12 FGD3
 FYVE, RhoGEF and PH domain containing 3
 9824
 0.19
chr17_71199413_71199564 0.12 COG1
 component of oligomeric golgi complex 1
 2266
 0.24
chrX_117644955_117645193 0.12 DOCK11
 dedicator of cytokinesis 11
 15202
 0.24
chr7_100140293_100140446 0.12 AGFG2
 ArfGAP with FG repeats 2
 3487
 0.11
chr15_70554588_70554739 0.11 ENSG00000200216
 .
 69088
 0.13
chr3_43064995_43065183 0.11 FAM198A
 family with sequence similarity 198, member A
 44049
 0.13
chr13_108979091_108979372 0.11 ENSG00000223177
 .
 25552
 0.22
chr20_47334105_47334366 0.11 ENSG00000251876
 .
 21750
 0.26
chr16_16193929_16194080 0.11 ABCC1
 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
 90291
 0.07
chr2_18003162_18003313 0.11 MSGN1
 mesogenin 1
 5474
 0.22
chr5_109032486_109032637 0.11 ENSG00000202512
 .
 2974
 0.27
chr12_68530648_68530810 0.11 IFNG
 interferon, gamma
 22798
 0.24
chr6_139616194_139616345 0.11 TXLNB
 taxilin beta
 2993
 0.28
chr13_20985266_20985502 0.11 ENSG00000263978
 .
 22601
 0.23
chr11_128589269_128589420 0.11 SENCR
 smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA
 23426
 0.17
chr1_41810525_41810676 0.11 FOXO6
 forkhead box O6
 16994
 0.21
chr17_17084049_17084292 0.11 MPRIP
 myosin phosphatase Rho interacting protein
 1298
 0.29
chr6_15078179_15078392 0.11 ENSG00000242989
 .
 34914
 0.21
chr10_111845210_111845446 0.11 ADD3
 adducin 3 (gamma)
 77606
 0.09
chr18_5158274_5158519 0.11 C18orf42
 chromosome 18 open reading frame 42
 38828
 0.21
chr1_200987046_200987749 0.11 KIF21B
 kinesin family member 21B
 5139
 0.21
chr11_64541210_64541478 0.11 SF1
 splicing factor 1
 3888
 0.14
chr9_36218264_36218537 0.11 CLTA
 clathrin, light chain A
 27440
 0.14
chr5_133881433_133881702 0.11 JADE2
 jade family PHD finger 2
 19240
 0.15
chr8_52913099_52913333 0.11 RP11-110G21.1
100922
 0.07
chr20_31116051_31116202 0.11 C20orf112
 chromosome 20 open reading frame 112
 7469
 0.18
chr2_8615200_8615353 0.11 AC011747.7
200620
 0.03
chr13_51487581_51487732 0.10 RNASEH2B-AS1
 RNASEH2B antisense RNA 1
 2808
 0.26
chr13_32998493_32998691 0.10 N4BP2L1
 NEDD4 binding protein 2-like 1
 3559
 0.24
chr3_81913343_81913495 0.10 GBE1
 glucan (1,4-alpha-), branching enzyme 1
 102107
 0.09
chr2_111506043_111506194 0.10 ACOXL
 acyl-CoA oxidase-like
 15686
 0.25
chr17_47872989_47873209 0.10 KAT7
 K(lysine) acetyltransferase 7
 6084
 0.16
chr14_93315070_93315221 0.10 GOLGA5
 golgin A5
 15674
 0.24
chr1_60036490_60036813 0.10 FGGY
 FGGY carbohydrate kinase domain containing
 17061
 0.29
chr12_93827062_93827301 0.10 UBE2N
 ubiquitin-conjugating enzyme E2N
 7851
 0.16
chr2_182171124_182171288 0.10 ENSG00000266705
 .
 827
 0.77
chr17_42579880_42580174 0.10 GPATCH8
 G patch domain containing 8
 732
 0.66
chr1_235439552_235439703 0.10 GGPS1
 geranylgeranyl diphosphate synthase 1
 51038
 0.11
chr12_2472562_2472713 0.10 CACNA1C-IT3
 CACNA1C intronic transcript 3 (non-protein coding)
 93695
 0.08
chr10_61631584_61631735 0.10 CCDC6
 coiled-coil domain containing 6
 34755
 0.21
chr4_140971490_140971641 0.10 RP11-392B6.1
77604
 0.1
chr14_66460757_66460908 0.10 CTD-2014B16.3
 Uncharacterized protein
 10409
 0.25
chr3_135908620_135908771 0.10 MSL2
 male-specific lethal 2 homolog (Drosophila)
 4701
 0.3
chr15_52338744_52338984 0.10 RP11-430B1.1
12960
 0.15
chr13_113840073_113840224 0.10 RP11-98F14.11
20651
 0.11
chr12_89632258_89632472 0.10 ENSG00000238302
 .
 43697
 0.19
chr8_66873049_66873243 0.10 DNAJC5B
 DnaJ (Hsp40) homolog, subfamily C, member 5 beta
 60649
 0.14
chr18_11852927_11853152 0.10 RP11-78A19.3
289
 0.82
chr2_144014874_144015136 0.10 RP11-190J23.1
85264
 0.1
chr1_211913474_211913689 0.10 ENSG00000241395
 .
 52167
 0.1
chr3_128836654_128836805 0.10 RAB43
 RAB43, member RAS oncogene family
 3895
 0.15
chr17_40574094_40574415 0.10 PTRF
 polymerase I and transcript release factor
 1281
 0.3
chr14_66304578_66304729 0.10 CTD-2014B16.3
 Uncharacterized protein
 166588
 0.04
chr2_26018392_26018619 0.10 ASXL2
 additional sex combs like 2 (Drosophila)
 15327
 0.23
chr20_44634089_44634268 0.10 MMP9
 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
 3369
 0.16
chr6_11276274_11276599 0.10 NEDD9
 neural precursor cell expressed, developmentally down-regulated 9
 43521
 0.17
chr1_100905257_100905795 0.10 RP5-837M10.4
46027
 0.13
chr12_27107136_27107312 0.09 FGFR1OP2
 FGFR1 oncogene partner 2
 15791
 0.13
chr1_235438349_235438790 0.09 GGPS1
 geranylgeranyl diphosphate synthase 1
 52096
 0.11
chr19_8639084_8639286 0.09 MYO1F
 myosin IF
 3137
 0.16
chr1_166133959_166134203 0.09 RP11-9L18.3
251
 0.9
chr3_151932265_151932416 0.09 MBNL1
 muscleblind-like splicing regulator 1
 53489
 0.14
chr16_79652126_79652340 0.09 MAF
 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
 17622
 0.26
chr14_50530285_50530492 0.09 ENSG00000201358
 .
 4898
 0.18
chr6_167550535_167550692 0.09 TCP10L2
 t-complex 10-like 2
 12355
 0.17
chrX_70325744_70326037 0.09 CXorf65
 chromosome X open reading frame 65
 565
 0.6
chr9_70851374_70851561 0.09 CBWD3
 COBW domain containing 3
 4930
 0.19
chr11_118097693_118098499 0.09 AMICA1
 adhesion molecule, interacts with CXADR antigen 1
 2287
 0.23
chr5_169708109_169708260 0.09 LCP2
 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
 13853
 0.22
chr10_121543359_121543582 0.09 INPP5F
 inositol polyphosphate-5-phosphatase F
 2331
 0.32
chr9_92078215_92078535 0.09 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 7507
 0.25
chr9_71633765_71634208 0.09 PRKACG
 protein kinase, cAMP-dependent, catalytic, gamma
 4947
 0.24
chr6_42740405_42740590 0.09 GLTSCR1L
 GLTSCR1-like
 9268
 0.17
chr1_193428730_193429035 0.09 ENSG00000252241
 .
 272192
 0.01
chr5_61873952_61874158 0.09 LRRC70
 leucine rich repeat containing 70
 507
 0.52
chr8_29945094_29945295 0.09 TMEM66
 transmembrane protein 66
 4471
 0.16
chr1_173487659_173487906 0.09 RP3-436N22.3
36608
 0.14
chr7_21469388_21469667 0.09 SP4
 Sp4 transcription factor
 1866
 0.34
chr22_21922789_21923120 0.09 UBE2L3
 ubiquitin-conjugating enzyme E2L 3
 928
 0.38
chr12_111613238_111613505 0.09 CUX2
 cut-like homeobox 2
 76121
 0.1
chr20_57723034_57723340 0.09 ZNF831
 zinc finger protein 831
 42888
 0.16
chr1_42123736_42123959 0.09 HIVEP3
 human immunodeficiency virus type I enhancer binding protein 3
 42825
 0.18
chr2_198072900_198073187 0.09 ANKRD44
 ankyrin repeat domain 44
 10281
 0.21
chr16_3058535_3058724 0.09 LA16c-380H5.2
3527
 0.07
chr1_42273293_42273444 0.09 ENSG00000264896
 .
 48556
 0.18
chr6_42740244_42740405 0.09 GLTSCR1L
 GLTSCR1-like
 9441
 0.17
chr3_98273092_98273322 0.09 GPR15
 G protein-coupled receptor 15
 22464
 0.13
chr6_42409736_42409944 0.09 TRERF1
 transcriptional regulating factor 1
 9159
 0.21
chr1_235587141_235587347 0.09 TBCE-AS1
 TBCE antisense RNA 1
 3054
 0.29
chr16_3125440_3125843 0.09 ENSG00000252561
 .
 6117
 0.06
chr1_151869347_151869629 0.09 THEM4
 thioesterase superfamily member 4
 12625
 0.12
chr2_198057877_198058189 0.09 AC013264.2
4682
 0.23
chrX_149646217_149646416 0.09 MAMLD1
 mastermind-like domain containing 1
 7036
 0.24
chr1_158788831_158789034 0.09 MNDA
 myeloid cell nuclear differentiation antigen
 12175
 0.17
chr8_103117650_103117985 0.09 NCALD
 neurocalcin delta
 18361
 0.2
chr9_135382524_135382903 0.09 BARHL1
 BarH-like homeobox 1
 74859
 0.09
chr19_47438297_47438633 0.09 ENSG00000252071
 .
 13081
 0.16
chr22_36550343_36550563 0.09 APOL3
 apolipoprotein L, 3
 6378
 0.24
chr11_20179253_20179404 0.09 DBX1
 developing brain homeobox 1
 2542
 0.34
chr7_25560467_25560618 0.09 ENSG00000222101
 .
 49746
 0.19
chr5_75600048_75600202 0.09 RP11-466P24.6
7162
 0.3
chr2_114189862_114190032 0.09 CBWD2
 COBW domain containing 2
 5321
 0.16
chr1_110333910_110334183 0.09 EPS8L3
 EPS8-like 3
 27397
 0.13
chr7_143007723_143007933 0.09 CLCN1
 chloride channel, voltage-sensitive 1
 5391
 0.1
chr5_67552449_67552681 0.09 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 16839
 0.26
chr18_56438172_56438323 0.08 RP11-126O1.4
18285
 0.15
chr19_5906272_5906423 0.08 VMAC
 vimentin-type intermediate filament associated coiled-coil protein
 1478
 0.18
chr5_179433301_179433452 0.08 ENSG00000198995
 .
 9021
 0.19
chr1_42267028_42267179 0.08 ENSG00000264896
 .
 42291
 0.19
chr4_140724600_140724880 0.08 ENSG00000252233
 .
 9153
 0.26
chr19_19185104_19185255 0.08 SLC25A42
 solute carrier family 25, member 42
 10371
 0.13
chr15_40342145_40342411 0.08 SRP14
 signal recognition particle 14kDa (homologous Alu RNA binding protein)
 10889
 0.15
chr21_36367069_36367374 0.08 RUNX1
 runt-related transcription factor 1
 54241
 0.18
chr20_50077608_50077759 0.08 ENSG00000266761
 .
 8169
 0.27
chr19_41811849_41812000 0.08 CCDC97
 coiled-coil domain containing 97
 4170
 0.13
chr18_43266469_43266620 0.08 SLC14A2
 solute carrier family 14 (urea transporter), member 2
 20437
 0.17
chrX_42259008_42259366 0.08 ENSG00000206896
 .
 225549
 0.02
chr22_26988789_26989025 0.08 TPST2
 tyrosylprotein sulfotransferase 2
 2780
 0.23
chr8_56756381_56756653 0.08 LYN
 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
 35855
 0.12
chr12_2349139_2349290 0.08 CACNA1C-AS4
 CACNA1C antisense RNA 4
 16569
 0.22
chr12_104865091_104865422 0.08 CHST11
 carbohydrate (chondroitin 4) sulfotransferase 11
 14477
 0.26
chr14_60761646_60761856 0.08 PPM1A
 protein phosphatase, Mg2+/Mn2+ dependent, 1A
 38271
 0.17
chr1_117058467_117058618 0.08 CD58
 CD58 molecule
 28670
 0.15
chr10_49719976_49720127 0.08 ARHGAP22-IT1
 ARHGAP22 intronic transcript 1 (non-protein coding)
 419
 0.87
chr3_107820810_107821187 0.08 CD47
 CD47 molecule
 11126
 0.3
chr5_118710365_118710516 0.08 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 18710
 0.2
chr2_37192955_37193106 0.08 STRN
 striatin, calmodulin binding protein
 576
 0.74
chr7_135623902_135624121 0.08 LUZP6
 leucine zipper protein 6
 11813
 0.14
chr4_89526439_89526704 0.08 HERC3
 HECT and RLD domain containing E3 ubiquitin protein ligase 3
 374
 0.86
chr1_26441433_26441584 0.08 PDIK1L
 PDLIM1 interacting kinase 1 like
 3168
 0.15
chr11_72866229_72866512 0.08 FCHSD2
 FCH and double SH3 domains 2
 13064
 0.2
chr7_21004042_21004193 0.08 SP8
 Sp8 transcription factor
 177612
 0.03
chr5_96345721_96346249 0.08 ENSG00000200884
 .
 47524
 0.12
chr10_90144841_90145001 0.08 RNLS
 renalase, FAD-dependent amine oxidase
 198026
 0.02
chr7_102072492_102072712 0.08 ORAI2
 ORAI calcium release-activated calcium modulator 2
 951
 0.34
chr10_6642170_6642420 0.08 PRKCQ
 protein kinase C, theta
 20032
 0.28
chr6_108139065_108139216 0.08 SCML4
 sex comb on midleg-like 4 (Drosophila)
 6376
 0.29
chr1_28526158_28526348 0.08 AL353354.2
817
 0.34
chr6_13686993_13687323 0.08 RANBP9
 RAN binding protein 9
 22
 0.98
chr6_122733810_122733961 0.08 HSF2
 heat shock transcription factor 2
 9416
 0.25
chr4_42634615_42634846 0.08 ATP8A1
 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
 24380
 0.21
chr9_92022718_92022899 0.08 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 1967
 0.41
chr2_143885609_143886070 0.08 ARHGAP15
 Rho GTPase activating protein 15
 1044
 0.64
chr2_143914477_143914920 0.08 RP11-190J23.1
15043
 0.24
chr10_11155205_11156000 0.08 CELF2-AS2
 CELF2 antisense RNA 2
 15166
 0.21
chr9_70495481_70495632 0.08 CBWD5
 COBW domain containing 5
 5310
 0.29
chr1_108624991_108625142 0.08 ENSG00000264753
 .
 63673
 0.12
chr8_19552777_19552928 0.08 CSGALNACT1
 chondroitin sulfate N-acetylgalactosaminyltransferase 1
 12580
 0.3
chr11_128348480_128348737 0.08 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 26681
 0.22
chr22_40322800_40322970 0.08 GRAP2
 GRB2-related adaptor protein 2
 244
 0.92
chr12_55372614_55372982 0.08 TESPA1
 thymocyte expressed, positive selection associated 1
 2824
 0.31
chr16_50802191_50802342 0.08 CYLD
 cylindromatosis (turban tumor syndrome)
 18806
 0.11
chr12_47600641_47601211 0.08 PCED1B
 PC-esterase domain containing 1B
 9126
 0.22
chr11_13944070_13944221 0.08 ENSG00000201856
 .
 15008
 0.29
chr8_59478164_59478344 0.08 SDCBP
 syndecan binding protein (syntenin)
 679
 0.77
chrX_102787503_102787654 0.08 RAB40A
 RAB40A, member RAS oncogene family
 13161
 0.15
chr16_85971060_85971235 0.08 IRF8
 interferon regulatory factor 8
 23228
 0.22
chr1_89992034_89992185 0.08 LRRC8B
 leucine rich repeat containing 8 family, member B
 1647
 0.46
chr12_21766880_21767202 0.08 GYS2
 glycogen synthase 2 (liver)
 9260
 0.2
chr3_33102387_33102538 0.08 GLB1
 galactosidase, beta 1
 35822
 0.13
chrX_19766831_19767108 0.08 SH3KBP1
 SH3-domain kinase binding protein 1
 1148
 0.65
chr2_182100905_182101073 0.08 ENSG00000266705
 .
 69390
 0.13
chr11_64537353_64537738 0.08 SF1
 splicing factor 1
 1002
 0.4
chr10_6096471_6096850 0.08 IL2RA
 interleukin 2 receptor, alpha
 7593
 0.15

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of EN2_GBX2_LBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.0 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.2 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.1 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.1 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.0 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0 0.1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.1 GO:0090047 obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0 0.1 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0097300 necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0 0.0 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.0 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.0 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0030910 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.0 GO:1901985 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.0 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.0 GO:0071224 cellular response to peptidoglycan(GO:0071224)
0.0 0.1 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.1 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.0 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.0 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.0 0.0 GO:0051532 NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0 0.0 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.1 GO:0006911 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.0 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.0 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.0 GO:0001714 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.0 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.0 0.0 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.0 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.0 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.0 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.0 0.0 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.0 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.0 GO:0002666 T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.0 0.1 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0 0.0 GO:0002691 regulation of cellular extravasation(GO:0002691)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.0 GO:0002890 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0 0.0 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.0 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.0 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.0 GO:0042584 chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.1 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.0 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 0.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.0 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.0 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.0 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.0 0.0 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.0 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.2 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.5 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse