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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for FIGLA

Z-value: 0.75

Motif logo

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Transcription factors associated with FIGLA

Gene Symbol Gene ID Gene Info
ENSG00000183733.6 FIGLA

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
FIGLAchr2_71016692_710171388600.548680-0.491.8e-01Click!
FIGLAchr2_71020635_7102078629350.2091390.294.4e-01Click!
FIGLAchr2_71017167_710175844000.818461-0.196.2e-01Click!
FIGLAchr2_71020886_7102103731860.2002870.029.7e-01Click!

Activity of the FIGLA motif across conditions

Conditions sorted by the z-value of the FIGLA motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr16_68107852_68108775 0.16 NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
10934
0.1
chr8_129254431_129254830 0.16 ENSG00000201782
.
21880
0.26
chr2_43402387_43402951 0.16 ZFP36L2
ZFP36 ring finger protein-like 2
51079
0.14
chr9_95724443_95724972 0.16 FGD3
FYVE, RhoGEF and PH domain containing 3
1536
0.44
chr12_95045333_95045484 0.16 TMCC3
transmembrane and coiled-coil domain family 3
1070
0.64
chr2_219182043_219182360 0.15 PNKD
paroxysmal nonkinesigenic dyskinesia
5695
0.11
chr1_236040463_236040645 0.14 LYST
lysosomal trafficking regulator
6318
0.17
chr18_74794512_74794972 0.14 MBP
myelin basic protein
22475
0.26
chr14_106559690_106559937 0.14 IGHV2-10
immunoglobulin heavy variable 2-10 (pseudogene)
162
0.82
chr1_206737001_206737160 0.14 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
6587
0.17
chr1_169673193_169673400 0.13 SELL
selectin L
7543
0.2
chr11_119558435_119558586 0.13 ENSG00000199217
.
31489
0.15
chr16_3915887_3916137 0.13 CREBBP
CREB binding protein
14109
0.21
chr3_183296518_183296669 0.13 KLHL6
kelch-like family member 6
23116
0.15
chr10_102242827_102242978 0.13 WNT8B
wingless-type MMTV integration site family, member 8B
20104
0.15
chr11_44248571_44248722 0.13 ALX4
ALX homeobox 4
83070
0.09
chr1_27943747_27943898 0.13 FGR
feline Gardner-Rasheed sarcoma viral oncogene homolog
6751
0.15
chr2_182029213_182029364 0.12 ENSG00000266705
.
141091
0.05
chr14_64330060_64330276 0.12 SYNE2
spectrin repeat containing, nuclear envelope 2
10436
0.21
chr1_203257611_203257822 0.12 BTG2
BTG family, member 2
16948
0.16
chr19_40458657_40458927 0.12 PSMC4
proteasome (prosome, macropain) 26S subunit, ATPase, 4
18120
0.14
chr6_167532699_167533025 0.12 CCR6
chemokine (C-C motif) receptor 6
3395
0.24
chr3_114044761_114044912 0.12 ENSG00000207770
.
9420
0.18
chr8_130987860_130988109 0.12 FAM49B
family with sequence similarity 49, member B
4748
0.22
chr10_14601089_14601359 0.12 FAM107B
family with sequence similarity 107, member B
3045
0.33
chr22_47080529_47080680 0.12 GRAMD4
GRAM domain containing 4
10099
0.22
chr2_234177088_234177288 0.12 ENSG00000252010
.
7185
0.15
chr17_71737008_71737211 0.11 SDK2
sidekick cell adhesion molecule 2
96881
0.08
chr10_11269625_11270026 0.11 RP3-323N1.2

56486
0.13
chr18_5310391_5310755 0.11 ZBTB14
zinc finger and BTB domain containing 14
13521
0.26
chr1_111436407_111436686 0.11 CD53
CD53 molecule
20770
0.16
chr11_59923299_59923450 0.11 MS4A6A
membrane-spanning 4-domains, subfamily A, member 6A
25765
0.17
chr1_229762263_229762506 0.11 URB2
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
403
0.6
chr1_154302822_154303147 0.11 ATP8B2
ATPase, aminophospholipid transporter, class I, type 8B, member 2
1709
0.2
chr20_43520651_43520802 0.11 YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
6333
0.15
chr16_2204860_2205013 0.11 ENSG00000206630
.
170
0.78
chr1_24846109_24846267 0.11 RCAN3
RCAN family member 3
5325
0.18
chr14_61814853_61815190 0.11 PRKCH
protein kinase C, eta
412
0.87
chr2_231201045_231201221 0.11 SP140L
SP140 nuclear body protein-like
5652
0.26
chr10_75817936_75818151 0.11 VCL
vinculin
25191
0.17
chr7_78901447_78901598 0.11 ENSG00000212482
.
71166
0.13
chr3_43430365_43430807 0.11 SNRK-AS1
SNRK antisense RNA 1
37132
0.15
chr19_18429556_18429758 0.11 LSM4
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
2588
0.15
chr6_87897937_87898088 0.11 ZNF292
zinc finger protein 292
32673
0.16
chr14_65457605_65457898 0.11 FNTB
farnesyltransferase, CAAX box, beta
4313
0.14
chr20_39510632_39510883 0.10 ENSG00000238908
.
27888
0.24
chr20_46364251_46364402 0.10 SULF2
sulfatase 2
49907
0.14
chr3_15133293_15133444 0.10 ZFYVE20
zinc finger, FYVE domain containing 20
7275
0.18
chr2_231185832_231185996 0.10 SP140L
SP140 nuclear body protein-like
5985
0.26
chr11_35063654_35064206 0.10 PDHX
pyruvate dehydrogenase complex, component X
64599
0.1
chrX_128902828_128903127 0.10 SASH3
SAM and SH3 domain containing 3
10983
0.19
chr2_136809758_136810032 0.10 AC093391.2

39860
0.17
chrX_109522408_109522577 0.10 AMMECR1-IT1
AMMECR1 intronic transcript 1 (non-protein coding)
27957
0.16
chr20_419708_419969 0.10 ENSG00000206797
.
11469
0.15
chr4_6927384_6927590 0.10 TBC1D14
TBC1 domain family, member 14
15512
0.16
chr1_206734149_206734498 0.10 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
3830
0.2
chr6_91121876_91122034 0.10 ENSG00000252676
.
34536
0.21
chr2_42523029_42523463 0.10 EML4
echinoderm microtubule associated protein like 4
5147
0.28
chr8_126304861_126305012 0.10 ENSG00000242170
.
22090
0.22
chr10_3777659_3777810 0.10 RP11-184A2.3

15525
0.22
chr7_64461641_64461792 0.10 ERV3-1
endogenous retrovirus group 3, member 1
5315
0.17
chr6_11439781_11439932 0.10 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
57275
0.13
chr2_174833582_174833733 0.10 SP3
Sp3 transcription factor
3227
0.39
chr13_114915217_114915368 0.10 RASA3
RAS p21 protein activator 3
17206
0.2
chr11_116798054_116798243 0.10 SIK3
SIK family kinase 3
29612
0.13
chr9_6915201_6915352 0.10 KDM4C
lysine (K)-specific demethylase 4C
10225
0.24
chr2_42425183_42425334 0.10 AC083949.1

27817
0.19
chr4_86538528_86538679 0.10 ARHGAP24
Rho GTPase activating protein 24
13297
0.29
chr1_109185458_109185656 0.10 HENMT1
HEN1 methyltransferase homolog 1 (Arabidopsis)
18120
0.18
chr3_72457004_72457192 0.09 RYBP
RING1 and YY1 binding protein
38971
0.21
chr2_136894487_136894962 0.09 CXCR4
chemokine (C-X-C motif) receptor 4
18989
0.26
chr3_177142358_177142705 0.09 ENSG00000252028
.
78809
0.12
chr2_219181462_219181800 0.09 PNKD
paroxysmal nonkinesigenic dyskinesia
6265
0.1
chr4_139997269_139997476 0.09 ELF2
E74-like factor 2 (ets domain transcription factor)
7972
0.15
chr9_21159368_21159519 0.09 ENSG00000199635
.
892
0.45
chr1_158990779_158990930 0.09 IFI16
interferon, gamma-inducible protein 16
5391
0.21
chr1_226870909_226871060 0.09 ITPKB-IT1
ITPKB intronic transcript 1 (non-protein coding)
8216
0.21
chr6_167362176_167362468 0.09 RP11-514O12.4

7290
0.15
chr9_134110097_134110353 0.09 NUP214
nucleoporin 214kDa
6544
0.18
chr17_26876127_26876878 0.09 UNC119
unc-119 homolog (C. elegans)
85
0.93
chr20_58836437_58836588 0.09 ENSG00000207802
.
47020
0.19
chr15_101147896_101148047 0.09 ASB7
ankyrin repeat and SOCS box containing 7
5157
0.16
chr6_14241209_14241434 0.09 ENSG00000238987
.
84628
0.1
chr5_169731249_169731487 0.09 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
6137
0.23
chr7_100846741_100846892 0.09 MOGAT3
monoacylglycerol O-acyltransferase 3
2514
0.14
chr6_53143430_53143680 0.09 ENSG00000264056
.
1764
0.38
chr11_65553168_65553319 0.09 OVOL1
ovo-like zinc finger 1
1250
0.26
chr2_128214705_128214856 0.09 AC010976.2

6438
0.15
chr16_50728117_50728492 0.09 NOD2
nucleotide-binding oligomerization domain containing 2
767
0.52
chr3_151909899_151910427 0.09 MBNL1
muscleblind-like splicing regulator 1
75666
0.1
chr19_16478953_16479699 0.09 EPS15L1
epidermal growth factor receptor pathway substrate 15-like 1
6562
0.16
chr16_48655371_48655896 0.09 N4BP1
NEDD4 binding protein 1
11513
0.18
chr4_154391718_154392045 0.09 KIAA0922
KIAA0922
4380
0.29
chr1_226873293_226873602 0.09 ITPKB-IT1
ITPKB intronic transcript 1 (non-protein coding)
10679
0.2
chr16_74619935_74620086 0.09 GLG1
golgi glycoprotein 1
20982
0.2
chr6_30475738_30475914 0.09 XXbac-BPG249D20.9

8217
0.13
chr7_141617224_141617397 0.09 OR9A4
olfactory receptor, family 9, subfamily A, member 4
1307
0.3
chr20_39148848_39148999 0.09 ENSG00000252434
.
103408
0.08
chr1_8594076_8594346 0.09 RERE
arginine-glutamic acid dipeptide (RE) repeats
8125
0.23
chr12_92949909_92950139 0.09 ENSG00000238865
.
11261
0.26
chr1_203260343_203260644 0.09 BTG2
BTG family, member 2
14171
0.17
chr4_40204107_40204407 0.09 RHOH
ras homolog family member H
2293
0.33
chr22_31725192_31725343 0.09 RP3-400N23.6

6068
0.12
chr5_53902252_53902403 0.09 SNX18
sorting nexin 18
88734
0.09
chr13_24827210_24827496 0.09 SPATA13-AS1
SPATA13 antisense RNA 1
1224
0.37
chr19_36443325_36443510 0.09 LRFN3
leucine rich repeat and fibronectin type III domain containing 3
15395
0.09
chr5_39146620_39146886 0.08 AC008964.1

41395
0.17
chr6_35559184_35559464 0.08 ENSG00000212579
.
60271
0.09
chr2_113937367_113937585 0.08 AC016683.5

4539
0.16
chr15_66432505_66432656 0.08 ENSG00000263512
.
100009
0.06
chr1_153487121_153487272 0.08 ENSG00000263841
.
13956
0.08
chr18_2950342_2950493 0.08 RP11-737O24.2

2078
0.26
chr1_226871894_226872507 0.08 ITPKB-IT1
ITPKB intronic transcript 1 (non-protein coding)
9432
0.21
chr9_95811540_95811691 0.08 SUSD3
sushi domain containing 3
9374
0.18
chr3_32497870_32498021 0.08 CMTM6
CKLF-like MARVEL transmembrane domain containing 6
46955
0.14
chr6_41675311_41675569 0.08 TFEB
transcription factor EB
1762
0.25
chrX_41200911_41201062 0.08 ENSG00000264573
.
4143
0.2
chr5_64046210_64046361 0.08 SREK1IP1
SREK1-interacting protein 1
18227
0.2
chr7_75029353_75029504 0.08 TRIM73
tripartite motif containing 73
1229
0.29
chr11_64541680_64542034 0.08 SF1
splicing factor 1
3375
0.15
chr1_154757692_154757865 0.08 KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
74541
0.07
chr6_24857746_24858061 0.08 ENSG00000263391
.
17610
0.17
chr22_47463732_47463883 0.08 ENSG00000221672
.
220004
0.02
chr15_77779927_77780078 0.08 HMG20A
high mobility group 20A
9367
0.26
chr12_92776883_92777034 0.08 RP11-693J15.4

38349
0.15
chr13_20539466_20539748 0.08 ZMYM2
zinc finger, MYM-type 2
6684
0.22
chr16_17440812_17440963 0.08 XYLT1
xylosyltransferase I
123851
0.06
chr7_72435345_72435555 0.08 TRIM74
tripartite motif containing 74
2034
0.18
chr3_13054781_13055070 0.08 IQSEC1
IQ motif and Sec7 domain 1
26389
0.23
chr12_46611375_46611659 0.08 SLC38A1
solute carrier family 38, member 1
49967
0.18
chr22_42689321_42689472 0.08 TCF20
transcription factor 20 (AR1)
50226
0.13
chr3_71924513_71924711 0.08 ENSG00000239250
.
48284
0.16
chr22_42239598_42239749 0.08 RP5-821D11.7

9004
0.12
chr3_151926787_151927119 0.08 MBNL1
muscleblind-like splicing regulator 1
58876
0.13
chr6_139493708_139493877 0.08 HECA
headcase homolog (Drosophila)
37543
0.17
chr17_40424777_40425014 0.08 AC003104.1

194
0.9
chr4_109081069_109081352 0.08 LEF1
lymphoid enhancer-binding factor 1
6247
0.24
chr16_3118727_3118954 0.08 ENSG00000252561
.
684
0.37
chr12_746864_747239 0.08 RP11-218M22.1

4789
0.18
chr17_56070062_56070285 0.08 VEZF1
vascular endothelial zinc finger 1
4553
0.17
chr17_2696074_2696428 0.08 RAP1GAP2
RAP1 GTPase activating protein 2
3481
0.22
chr1_225656318_225656532 0.08 RP11-496N12.6

3380
0.27
chr14_22998856_22999007 0.08 TRAJ15
T cell receptor alpha joining 15
351
0.79
chr1_113170618_113170793 0.08 ENSG00000252750
.
6701
0.13
chr12_65061545_65061862 0.08 RP11-338E21.3

12904
0.13
chr7_104985093_104985329 0.08 ENSG00000201179
.
11974
0.21
chr5_1497877_1498028 0.08 LPCAT1
lysophosphatidylcholine acyltransferase 1
26140
0.19
chr1_154440668_154440819 0.08 RP11-350G8.9

11745
0.12
chr17_8844881_8845564 0.08 PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
23802
0.21
chr6_133073763_133073914 0.08 RP1-55C23.7

24
0.96
chr8_129670430_129670618 0.08 ENSG00000221351
.
161516
0.04
chr1_1542024_1542542 0.08 C1orf233
chromosome 1 open reading frame 233
6807
0.09
chr3_56705961_56706112 0.08 FAM208A
family with sequence similarity 208, member A
7677
0.29
chr15_83419735_83419886 0.08 RP11-752G15.6

474
0.7
chr15_77300295_77300505 0.08 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
7752
0.2
chr17_80517753_80517904 0.08 FOXK2
forkhead box K2
588
0.61
chr8_29683682_29683878 0.08 ENSG00000221003
.
102341
0.07
chr22_39369446_39369597 0.08 APOBEC3B
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
8831
0.12
chr13_52397484_52397635 0.08 RP11-327P2.5

19126
0.17
chr16_84409256_84409407 0.08 ATP2C2
ATPase, Ca++ transporting, type 2C, member 2
7198
0.21
chr16_67728613_67728764 0.08 GFOD2
glucose-fructose oxidoreductase domain containing 2
24636
0.08
chr13_41201246_41201477 0.08 FOXO1
forkhead box O1
39373
0.17
chr2_181911925_181912076 0.08 UBE2E3
ubiquitin-conjugating enzyme E2E 3
65250
0.13
chr1_117311065_117311639 0.08 CD2
CD2 molecule
14263
0.21
chr5_52096687_52096895 0.07 CTD-2288O8.1

12931
0.19
chr7_8169902_8170053 0.07 AC006042.6

16322
0.2
chr10_14594956_14595285 0.07 FAM107B
family with sequence similarity 107, member B
1108
0.6
chr6_497453_497604 0.07 RP1-20B11.2

26643
0.24
chr17_7154048_7154378 0.07 CTDNEP1
CTD nuclear envelope phosphatase 1
392
0.45
chr12_50156674_50156825 0.07 TMBIM6
transmembrane BAX inhibitor motif containing 6
10002
0.16
chrX_123345247_123345413 0.07 ENSG00000252693
.
13737
0.27
chr4_55620528_55620679 0.07 KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
96518
0.09
chr9_92113326_92114071 0.07 SEMA4D
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
653
0.53
chr20_2273870_2274021 0.07 TGM3
transglutaminase 3
2702
0.34
chr9_515997_516400 0.07 ENSG00000264949
.
8645
0.14
chr5_55909423_55909817 0.07 AC022431.2
Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.
7561
0.26
chr6_35703353_35703635 0.07 RP3-510O8.4

1230
0.28
chr10_74053915_74054066 0.07 RP11-442H21.2

18252
0.15
chr3_171862867_171863018 0.07 FNDC3B
fibronectin type III domain containing 3B
18178
0.25
chr1_200976988_200977172 0.07 KIF21B
kinesin family member 21B
15456
0.18
chr20_62535397_62535572 0.07 ENSG00000199805
.
4824
0.08
chr2_97010416_97010595 0.07 NCAPH
non-SMC condensin I complex, subunit H
8949
0.15
chr12_58176126_58176280 0.07 TSFM
Ts translation elongation factor, mitochondrial
169
0.85
chr7_37489254_37489473 0.07 ELMO1
engulfment and cell motility 1
511
0.8
chrX_15815885_15816036 0.07 ZRSR2
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
7365
0.21
chr11_77159328_77159479 0.07 DKFZP434E1119

25013
0.18
chr22_27071985_27072283 0.07 CRYBA4
crystallin, beta A4
54206
0.12
chr11_67046455_67046752 0.07 ANKRD13D
ankyrin repeat domain 13 family, member D
9415
0.11
chr3_182683857_182684049 0.07 DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1
13986
0.2
chr3_107789495_107789646 0.07 CD47
CD47 molecule
11191
0.3
chr7_155131318_155131469 0.07 BLACE
B-cell acute lymphoblastic leukemia expressed
29236
0.15
chr1_165819042_165819193 0.07 UCK2
uridine-cytidine kinase 2
22058
0.17
chrX_135669720_135670141 0.07 ENSG00000252320
.
4531
0.17
chr12_29318585_29318886 0.07 FAR2
fatty acyl CoA reductase 2
16602
0.24
chr1_43273074_43273425 0.07 CCDC23
coiled-coil domain containing 23
9226
0.12
chrX_19729925_19730220 0.07 SH3KBP1
SH3-domain kinase binding protein 1
28883
0.25
chr10_116299368_116299596 0.07 ABLIM1
actin binding LIM protein 1
12792
0.27
chr2_237878465_237879184 0.07 ENSG00000202341
.
45124
0.17
chr21_36318885_36319060 0.07 RUNX1
runt-related transcription factor 1
56885
0.17
chr9_110377144_110377295 0.07 ENSG00000202308
.
48308
0.17

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of FIGLA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.1 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.0 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.0 GO:0001821 histamine secretion(GO:0001821)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.0 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.0 GO:0003953 NAD+ nucleosidase activity(GO:0003953)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions