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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for FLI1

Z-value: 1.87

Motif logo

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Transcription factors associated with FLI1

Gene Symbol Gene ID Gene Info
ENSG00000151702.12 FLI1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
FLI1chr11_128666438_128666589318280.162451-0.801.0e-02Click!
FLI1chr11_128672561_128672729379600.1441420.722.9e-02Click!
FLI1chr11_128561762_1285621924120.8279080.665.1e-02Click!
FLI1chr11_128633066_12863332914880.4601250.656.0e-02Click!
FLI1chr11_128613865_128614016207450.1899440.646.1e-02Click!

Activity of the FLI1 motif across conditions

Conditions sorted by the z-value of the FLI1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr13_100071950_100072184 0.52 ENSG00000266207
.
33656
0.15
chr2_127292142_127292584 0.49 GYPC
glycophorin C (Gerbich blood group)
121146
0.06
chr6_156175894_156176045 0.47 ENSG00000221456
.
91962
0.1
chr14_22573447_22573919 0.45 ENSG00000238634
.
37204
0.21
chr19_55663404_55663555 0.44 TNNT1
troponin T type 1 (skeletal, slow)
2757
0.12
chr10_22331963_22332114 0.44 DNAJC1
DnaJ (Hsp40) homolog, subfamily C, member 1
39340
0.2
chr21_27019613_27019764 0.44 JAM2
junctional adhesion molecule 2
7778
0.21
chr20_9125598_9125908 0.42 PLCB4
phospholipase C, beta 4
21252
0.26
chr12_68382989_68383156 0.42 IFNG-AS1
IFNG antisense RNA 1
153
0.98
chr2_196337351_196337701 0.42 ENSG00000202206
.
41234
0.21
chr11_45057187_45057338 0.42 PRDM11
PR domain containing 11
58302
0.14
chr14_90081515_90082105 0.41 FOXN3
forkhead box N3
3664
0.17
chr7_28645131_28645282 0.41 CREB5
cAMP responsive element binding protein 5
3472
0.39
chr9_90104197_90104348 0.40 DAPK1
death-associated protein kinase 1
7871
0.28
chr2_89488681_89488919 0.40 IGKV3-25
immunoglobulin kappa variable 3-25 (pseudogene)
3440
0.08
chr10_104372676_104372839 0.39 ENSG00000207029
.
21476
0.14
chr2_31021459_31021724 0.39 CAPN13
calpain 13
8720
0.31
chr17_28002009_28002239 0.38 RP11-68I3.11

29259
0.09
chr22_45950705_45950893 0.38 FBLN1
fibulin 1
36136
0.15
chr17_29584046_29584263 0.38 OMG
oligodendrocyte myelin glycoprotein
40275
0.11
chr7_27439570_27439956 0.38 EVX1-AS
EVX1 antisense RNA
152915
0.03
chr5_137197415_137197826 0.38 MYOT
myotilin
5860
0.19
chr10_72523254_72523405 0.38 TBATA
thymus, brain and testes associated
19059
0.21
chr12_26481061_26481490 0.38 RP11-283G6.4

7514
0.17
chr16_11048545_11048707 0.37 CLEC16A
C-type lectin domain family 16, member A
10188
0.14
chr5_55218982_55219184 0.37 AC008914.1
Uncharacterized protein
5486
0.19
chr22_19986182_19986333 0.37 ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
7940
0.11
chr7_117479656_117479807 0.37 CTTNBP2
cortactin binding protein 2
31961
0.24
chr2_238357915_238358414 0.37 AC112721.1
Uncharacterized protein
24245
0.16
chr17_8316617_8316964 0.37 NDEL1
nudE neurodevelopment protein 1-like 1
341
0.8
chr7_5536857_5537380 0.37 ENSG00000207973
.
1570
0.27
chr2_68647914_68648065 0.37 FBXO48
F-box protein 48
46401
0.11
chr12_63804047_63804198 0.36 DPY19L2
dpy-19-like 2 (C. elegans)
173820
0.03
chr2_233637307_233637592 0.36 KCNJ13
potassium inwardly-rectifying channel, subfamily J, member 13
1334
0.35
chr19_51714203_51714354 0.36 SIGLEC22P
sialic acid binding Ig-like lectin 22, pseudogene
88
0.94
chr2_16105641_16106067 0.35 ENSG00000243541
.
14751
0.18
chr14_101013755_101014380 0.35 BEGAIN
brain-enriched guanylate kinase-associated
368
0.82
chr10_4929735_4930120 0.35 AKR1C1
aldo-keto reductase family 1, member C1
4869
0.24
chr3_48362598_48362756 0.35 ENSG00000252466
.
4728
0.13
chr1_210755656_210755807 0.35 HHAT
hedgehog acyltransferase
142804
0.05
chr19_35950298_35950449 0.35 FFAR2
free fatty acid receptor 2
9756
0.11
chrX_4171213_4171579 0.35 ENSG00000264861
.
330145
0.01
chr10_18707684_18707835 0.34 CACNB2
calcium channel, voltage-dependent, beta 2 subunit
18017
0.26
chr11_64976530_64976899 0.34 CAPN1
calpain 1, (mu/I) large subunit
25907
0.08
chr3_15501836_15502208 0.34 EAF1-AS1
EAF1 antisense RNA 1
8913
0.12
chr6_112809462_112809613 0.34 ENSG00000239095
.
11609
0.25
chr1_33383226_33383377 0.34 ENSG00000221423
.
8594
0.13
chr7_37450319_37450698 0.33 ENSG00000200113
.
8723
0.2
chr21_45587190_45587395 0.33 AP001055.1

6288
0.15
chr14_73127890_73128041 0.33 ENSG00000206751
.
192074
0.03
chr7_121012833_121012984 0.33 FAM3C
family with sequence similarity 3, member C
23454
0.22
chr20_50268856_50269051 0.33 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
89583
0.09
chr9_116187391_116187591 0.33 C9orf43
chromosome 9 open reading frame 43
14469
0.13
chr2_171218787_171218938 0.33 AC012594.1

11234
0.29
chr11_47276308_47276801 0.32 NR1H3
nuclear receptor subfamily 1, group H, member 3
2601
0.15
chr6_113269482_113269633 0.32 ENSG00000201386
.
23138
0.28
chr1_40241908_40242269 0.32 OXCT2
3-oxoacid CoA transferase 2
5068
0.14
chr20_47426342_47426648 0.32 PREX1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
17925
0.25
chr15_70150164_70150315 0.32 ENSG00000215958
.
72396
0.12
chr7_13948456_13948642 0.32 ETV1
ets variant 1
77517
0.12
chr6_21948358_21948509 0.32 ENSG00000222515
.
137340
0.05
chr19_33648919_33649221 0.32 ENSG00000264355
.
18908
0.12
chr16_85936515_85936777 0.32 IRF8
interferon regulatory factor 8
202
0.96
chr11_33931912_33932063 0.32 LMO2
LIM domain only 2 (rhombotin-like 1)
18151
0.2
chr1_42195372_42195655 0.32 HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
28841
0.2
chr11_128600956_128601302 0.32 FLI1
Fli-1 proto-oncogene, ETS transcription factor
33556
0.15
chr10_134200331_134200482 0.32 PWWP2B
PWWP domain containing 2B
10266
0.19
chr15_86231778_86232166 0.32 AKAP13
A kinase (PRKA) anchor protein 13
11704
0.11
chr15_82240061_82240448 0.32 ENSG00000222521
.
96381
0.08
chr18_46126568_46126846 0.32 CTIF
CBP80/20-dependent translation initiation factor
60241
0.12
chr3_152341188_152341339 0.32 RP11-362A9.3

126661
0.06
chr12_4544665_4544942 0.31 FGF6
fibroblast growth factor 6
8582
0.22
chr14_93053486_93054197 0.31 RIN3
Ras and Rab interactor 3
65005
0.13
chr18_54236748_54236947 0.31 TXNL1
thioredoxin-like 1
44875
0.19
chr22_39355641_39355969 0.31 APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
2278
0.22
chr10_1984923_1985074 0.31 ENSG00000252998
.
155363
0.04
chr5_78123610_78123862 0.31 ARSB
arylsulfatase B
157872
0.04
chr12_108707819_108708296 0.31 CMKLR1
chemokine-like receptor 1
3637
0.33
chr6_16092423_16092777 0.31 MYLIP
myosin regulatory light chain interacting protein
36756
0.16
chr17_79216045_79216279 0.31 C17orf89
chromosome 17 open reading frame 89
2751
0.14
chr15_93178645_93178796 0.31 FAM174B
family with sequence similarity 174, member B
3754
0.29
chr4_77465929_77466080 0.30 ENSG00000207307
.
12524
0.16
chr21_26672128_26672427 0.30 ENSG00000238660
.
39042
0.2
chr5_84165787_84165938 0.30 CTD-2269F5.1

484565
0.01
chr14_101129324_101129521 0.30 DLK1
delta-like 1 homolog (Drosophila)
62620
0.06
chr1_3233135_3233286 0.30 PRDM16
PR domain containing 16
72514
0.11
chr19_30113236_30113387 0.30 POP4
processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
16083
0.21
chr17_29863686_29863837 0.30 ENSG00000266459
.
1860
0.22
chr2_206645417_206645568 0.30 AC007362.3

16762
0.25
chr19_33966060_33966339 0.30 PEPD
peptidase D
2791
0.35
chr9_4596503_4596823 0.30 SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
24328
0.19
chr13_99892072_99892468 0.30 GPR18
G protein-coupled receptor 18
18358
0.17
chr10_63150600_63150931 0.30 TMEM26
transmembrane protein 26
40325
0.19
chrX_153401312_153401677 0.30 OPN1LW
opsin 1 (cone pigments), long-wave-sensitive
8204
0.13
chr3_132341084_132341235 0.30 ACKR4
atypical chemokine receptor 4
25078
0.16
chr9_31335901_31336264 0.30 ENSG00000211510
.
561856
0.0
chr11_6693256_6693542 0.29 MRPL17
mitochondrial ribosomal protein L17
11148
0.1
chr2_7028558_7028709 0.29 RSAD2
radical S-adenosyl methionine domain containing 2
9708
0.17
chr1_192543281_192543506 0.29 RGS1
regulator of G-protein signaling 1
1464
0.44
chr8_143125217_143125368 0.29 ENSG00000221123
.
98432
0.08
chr17_75202331_75202597 0.29 SEC14L1
SEC14-like 1 (S. cerevisiae)
433
0.86
chr18_43973888_43974039 0.29 RNF165
ring finger protein 165
59776
0.14
chr6_509732_509883 0.29 RP1-20B11.2

14364
0.28
chr10_114981438_114981803 0.29 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
70778
0.12
chr20_45993868_45994019 0.29 ZMYND8
zinc finger, MYND-type containing 8
8376
0.15
chr3_119069024_119069236 0.29 ENSG00000207310
.
8343
0.18
chr7_101363702_101363902 0.29 MYL10
myosin, light chain 10, regulatory
91226
0.08
chr15_32878891_32879042 0.29 GOLGA8N
golgin A8 family, member N
6691
0.14
chrX_65081346_65081497 0.29 RP6-159A1.3

138172
0.05
chr2_182715737_182716031 0.29 RP11-366L5.1

40506
0.16
chr1_232308482_232308858 0.29 ENSG00000242794
.
49942
0.19
chr16_85863066_85863326 0.29 COX4I1
cytochrome c oxidase subunit IV isoform 1
28388
0.11
chr1_110976057_110976208 0.29 LAMTOR5-AS1
LAMTOR5 antisense RNA 1
7539
0.13
chr8_120559165_120559316 0.29 ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
46008
0.16
chr18_63724785_63724936 0.29 RP11-389J22.1

192362
0.03
chr12_52752569_52752720 0.28 KRT85
keratin 85
5762
0.1
chr5_124038326_124038477 0.28 RP11-436H11.2

26123
0.13
chr4_48216156_48216409 0.28 TEC
tec protein tyrosine kinase
55599
0.11
chr6_41727802_41727953 0.28 PGC
progastricsin (pepsinogen C)
6030
0.11
chr2_97627578_97627763 0.28 ENSG00000252845
.
5118
0.16
chr6_130898230_130898569 0.28 ENSG00000202438
.
3142
0.38
chr16_75661748_75661899 0.28 ADAT1
adenosine deaminase, tRNA-specific 1
4625
0.16
chr12_10820287_10820438 0.28 STYK1
serine/threonine/tyrosine kinase 1
5895
0.19
chr8_66104008_66104159 0.28 CYP7B1
cytochrome P450, family 7, subfamily B, polypeptide 1
392765
0.01
chr4_165797912_165798063 0.28 FAM218A
family with sequence similarity 218, member A
80113
0.09
chr9_133992553_133992787 0.28 AIF1L
allograft inflammatory factor 1-like
5881
0.15
chr11_124750172_124750368 0.28 ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
2986
0.14
chr19_17516947_17517514 0.28 MVB12A
multivesicular body subunit 12A
276
0.71
chr11_36472811_36473244 0.28 RP11-219O3.2

25355
0.17
chr18_68285128_68285324 0.28 GTSCR1
Gilles de la Tourette syndrome chromosome region, candidate 1
32721
0.23
chr1_22273488_22273683 0.28 HSPG2
heparan sulfate proteoglycan 2
9795
0.12
chr2_217351726_217351877 0.28 AC098820.4

118
0.96
chr3_48438962_48439113 0.28 ENSG00000265053
.
17713
0.09
chr4_8263775_8264072 0.28 HTRA3
HtrA serine peptidase 3
7569
0.22
chr17_80842956_80843153 0.27 TBCD
tubulin folding cofactor D
377
0.87
chr20_19711383_19711534 0.27 ENSG00000239120
.
4095
0.25
chr12_111798877_111799028 0.27 FAM109A
family with sequence similarity 109, member A
2564
0.27
chrX_31154186_31154373 0.27 FTHL17
ferritin, heavy polypeptide-like 17
64109
0.13
chr15_32398994_32399230 0.27 ENSG00000201084
.
68440
0.11
chr12_96580506_96580772 0.27 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
7521
0.22
chr11_36112461_36112922 0.27 ENSG00000263389
.
81043
0.09
chr2_145340674_145340842 0.27 ZEB2
zinc finger E-box binding homeobox 2
62137
0.14
chr13_27293812_27293974 0.27 GPR12
G protein-coupled receptor 12
40534
0.19
chr16_50754093_50754244 0.27 RP11-327F22.6

7413
0.11
chr16_29713724_29714191 0.27 QPRT
quinolinate phosphoribosyltransferase
23454
0.09
chr10_72260699_72260857 0.27 PALD1
phosphatase domain containing, paladin 1
22201
0.18
chr6_139646746_139647075 0.27 TXLNB
taxilin beta
33634
0.16
chr7_50267806_50268026 0.27 IKZF1
IKAROS family zinc finger 1 (Ikaros)
76408
0.1
chr4_185334881_185335225 0.27 IRF2
interferon regulatory factor 2
4691
0.24
chr1_44533481_44533632 0.27 SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
36422
0.11
chr17_73098037_73098188 0.26 ARMC7
armadillo repeat containing 7
7935
0.08
chr1_232587915_232588066 0.26 SIPA1L2
signal-induced proliferation-associated 1 like 2
10173
0.32
chr7_80242837_80242988 0.26 CD36
CD36 molecule (thrombospondin receptor)
10487
0.3
chr8_95874685_95874854 0.26 RP11-347C18.5

22068
0.12
chr15_70792883_70793118 0.26 UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
201620
0.03
chr1_156494924_156495366 0.26 ENSG00000238843
.
3977
0.14
chr5_157019766_157020019 0.26 ENSG00000252068
.
13387
0.15
chr6_159477984_159478323 0.26 TAGAP
T-cell activation RhoGTPase activating protein
11969
0.2
chr10_102669234_102669601 0.26 ENSG00000222072
.
2380
0.18
chr5_74272731_74272882 0.26 GCNT4
glucosaminyl (N-acetyl) transferase 4, core 2
53918
0.14
chr11_78104017_78104246 0.26 RP11-452H21.2

5024
0.21
chr6_71962715_71962912 0.26 RP11-154D6.1

31822
0.17
chr2_25628947_25629098 0.26 AC104699.1

14964
0.23
chr5_157253662_157253813 0.26 ENSG00000206819
.
17631
0.18
chr19_42036756_42036962 0.26 CEACAM21
carcinoembryonic antigen-related cell adhesion molecule 21
19027
0.15
chr7_132118026_132118308 0.26 AC011625.1

81074
0.11
chr3_24079611_24079788 0.26 NKIRAS1
NFKB inhibitor interacting Ras-like 1
91617
0.08
chr12_118893068_118893219 0.26 SUDS3
suppressor of defective silencing 3 homolog (S. cerevisiae)
78785
0.1
chr3_177256800_177257020 0.26 ENSG00000252028
.
35570
0.22
chrX_12969294_12969579 0.26 TMSB4X
thymosin beta 4, X-linked
23791
0.18
chr19_35823671_35823968 0.26 CD22
CD22 molecule
900
0.35
chr5_175097575_175097980 0.26 HRH2
histamine receptor H2
10687
0.21
chr11_63900086_63900237 0.26 RP11-21A7A.3

13479
0.1
chr4_25785321_25785472 0.26 SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
4571
0.26
chr20_56056902_56057055 0.26 CTCFL
CCCTC-binding factor (zinc finger protein)-like
42335
0.14
chr8_71064792_71065043 0.26 NCOA2
nuclear receptor coactivator 2
4222
0.29
chr2_124676854_124677005 0.26 ENSG00000223118
.
49782
0.17
chr11_12311595_12311988 0.26 MICALCL
MICAL C-terminal like
3344
0.23
chr1_54442253_54442404 0.26 LRRC42
leucine rich repeat containing 42
30297
0.11
chr11_22802628_22802929 0.25 RP11-17A1.3

48148
0.13
chr2_188440142_188440373 0.25 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
9770
0.24
chr5_58945275_58945500 0.25 ENSG00000202601
.
54142
0.16
chr5_137417080_137417231 0.25 WNT8A
wingless-type MMTV integration site family, member 8A
2426
0.18
chr11_121415762_121415913 0.25 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
21597
0.27
chr9_138114288_138114439 0.25 AL390778.1
Uncharacterized protein
36912
0.18
chr4_26749010_26749349 0.25 ENSG00000200999
.
45248
0.17
chr12_71897694_71897890 0.25 TSPAN8
tetraspanin 8
62114
0.11
chr17_40216123_40216458 0.25 ZNF385C
zinc finger protein 385C
1215
0.31
chr3_160690829_160691249 0.25 B3GALNT1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
127916
0.05
chr18_29212837_29212988 0.25 ENSG00000252379
.
36429
0.12
chr1_231747913_231748254 0.25 LINC00582
long intergenic non-protein coding RNA 582
247
0.93
chr17_73494158_73494309 0.25 KIAA0195
KIAA0195
349
0.74
chr15_60223430_60223581 0.25 FOXB1
forkhead box B1
72916
0.12
chr6_2141396_2141691 0.25 GMDS
GDP-mannose 4,6-dehydratase
34682
0.24
chr3_18169887_18170081 0.25 RP11-158G18.1

281143
0.01
chr7_128709200_128709351 0.25 ENSG00000238733
.
7690
0.17
chr16_57842016_57842172 0.25 CTD-2600O9.1
uncharacterized protein LOC388282
2455
0.21
chr6_100057836_100058187 0.25 PRDM13
PR domain containing 13
3405
0.23
chr7_4169088_4169239 0.25 SDK1
sidekick cell adhesion molecule 1
178611
0.03
chr22_29563703_29563995 0.25 ENSG00000251952
.
23947
0.12

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of FLI1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.1 0.7 GO:0032753 positive regulation of interleukin-4 production(GO:0032753)
0.1 0.1 GO:2000050 regulation of non-canonical Wnt signaling pathway(GO:2000050)
0.1 0.4 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 0.4 GO:0045056 transcytosis(GO:0045056)
0.1 0.3 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 0.4 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.3 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.3 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.1 0.4 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.1 0.7 GO:0001562 response to protozoan(GO:0001562)
0.1 0.3 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.1 0.1 GO:0045630 positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.1 0.2 GO:0019372 lipoxygenase pathway(GO:0019372)
0.1 0.1 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.1 0.3 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1 0.2 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 0.1 GO:0048537 mucosal-associated lymphoid tissue development(GO:0048537)
0.1 0.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.1 GO:0090116 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.1 0.1 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.1 0.3 GO:0002857 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.1 0.2 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.1 0.2 GO:0002085 inhibition of neuroepithelial cell differentiation(GO:0002085)
0.1 0.1 GO:0033622 integrin activation(GO:0033622)
0.1 0.1 GO:0032632 interleukin-3 production(GO:0032632)
0.1 0.4 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 0.2 GO:1903224 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.1 0.2 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.1 0.3 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 0.2 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.2 GO:0008291 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.1 0.2 GO:0007028 cytoplasm organization(GO:0007028)
0.1 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.1 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.1 0.2 GO:0001845 phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.1 0.2 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 0.4 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.2 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 0.3 GO:0046874 quinolinate metabolic process(GO:0046874)
0.0 0.0 GO:0002885 positive regulation of hypersensitivity(GO:0002885)
0.0 0.1 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.2 GO:0090009 primitive streak formation(GO:0090009)
0.0 0.1 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.3 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.4 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0 0.2 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0 0.2 GO:0032100 positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0 0.1 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.1 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0002540 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.1 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.2 GO:0060437 lung growth(GO:0060437)
0.0 0.2 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.3 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.2 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 0.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.1 GO:0046931 pore complex assembly(GO:0046931)
0.0 0.0 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.2 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.1 GO:0010587 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0 0.2 GO:0003010 voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0 0.1 GO:0009189 deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0 0.1 GO:1903053 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.1 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.1 GO:0002418 immune response to tumor cell(GO:0002418)
0.0 0.1 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.1 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.0 0.1 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.4 GO:0019059 obsolete initiation of viral infection(GO:0019059)
0.0 0.1 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0051971 positive regulation of transmission of nerve impulse(GO:0051971)
0.0 0.1 GO:0051024 positive regulation of immunoglobulin secretion(GO:0051024)
0.0 0.1 GO:0045002 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.0 GO:0072179 nephric duct formation(GO:0072179)
0.0 0.1 GO:0002407 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0 0.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.1 GO:0090192 regulation of glomerulus development(GO:0090192)
0.0 0.2 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.1 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.1 GO:0003351 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.2 GO:0050860 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.3 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.2 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0 0.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:0006911 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.1 GO:0021801 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.1 GO:0060685 regulation of prostatic bud formation(GO:0060685)
0.0 0.1 GO:0042117 monocyte activation(GO:0042117)
0.0 0.1 GO:0046881 positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0 0.1 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.1 GO:0022601 menstrual cycle phase(GO:0022601)
0.0 0.1 GO:0032700 negative regulation of interleukin-17 production(GO:0032700)
0.0 0.0 GO:0002679 respiratory burst involved in defense response(GO:0002679)
0.0 0.2 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.1 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 0.1 GO:0014034 neural crest formation(GO:0014029) neural crest cell fate commitment(GO:0014034)
0.0 0.1 GO:0045992 negative regulation of embryonic development(GO:0045992)
0.0 0.1 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.1 GO:0048478 replication fork protection(GO:0048478)
0.0 0.1 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.1 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.1 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.1 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.0 GO:0003077 obsolete negative regulation of diuresis(GO:0003077)
0.0 0.1 GO:0055064 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0 0.1 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.0 0.1 GO:1901538 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 0.1 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.1 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.0 GO:0060510 lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0 0.1 GO:0006007 glucose catabolic process(GO:0006007)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0060242 contact inhibition(GO:0060242)
0.0 0.2 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.1 GO:0060123 regulation of growth hormone secretion(GO:0060123)
0.0 0.0 GO:1901021 positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of cation channel activity(GO:2001259)
0.0 0.1 GO:0060044 negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0 0.1 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.0 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.2 GO:0007141 male meiosis I(GO:0007141)
0.0 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.1 GO:0032328 alanine transport(GO:0032328)
0.0 0.1 GO:0016102 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.0 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.1 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.0 0.0 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.2 GO:0033003 regulation of mast cell activation(GO:0033003)
0.0 0.0 GO:0035066 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.0 GO:0060913 cardiac cell fate determination(GO:0060913)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.0 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0 0.2 GO:0045885 obsolete positive regulation of survival gene product expression(GO:0045885)
0.0 0.2 GO:0048854 brain morphogenesis(GO:0048854)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.0 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.1 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.0 GO:0033091 positive regulation of immature T cell proliferation(GO:0033091)
0.0 0.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.0 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.0 GO:0071503 response to heparin(GO:0071503)
0.0 0.1 GO:0016999 antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.0 0.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.0 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.1 GO:0009143 nucleoside triphosphate catabolic process(GO:0009143)
0.0 0.2 GO:0050798 activated T cell proliferation(GO:0050798)
0.0 0.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.0 GO:0070254 mucus secretion(GO:0070254)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0060004 reflex(GO:0060004)
0.0 0.0 GO:0014889 muscle atrophy(GO:0014889)
0.0 0.2 GO:0051319 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.0 GO:1903115 regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0 0.1 GO:0032212 positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0 0.1 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.2 GO:0002715 regulation of natural killer cell mediated immunity(GO:0002715) regulation of natural killer cell mediated cytotoxicity(GO:0042269)
0.0 0.1 GO:0008356 asymmetric cell division(GO:0008356)
0.0 0.0 GO:0010988 regulation of low-density lipoprotein particle clearance(GO:0010988)
0.0 0.1 GO:0040009 regulation of growth rate(GO:0040009)
0.0 0.0 GO:0019042 viral latency(GO:0019042)
0.0 0.0 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.0 GO:0032714 regulation of interleukin-13 production(GO:0032656) negative regulation of interleukin-5 production(GO:0032714)
0.0 0.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0048488 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.1 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0 0.0 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.1 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.0 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.1 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.0 GO:0071220 response to bacterial lipoprotein(GO:0032493) response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221)
0.0 0.0 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.2 GO:0051923 sulfation(GO:0051923)
0.0 0.2 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.0 0.1 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.1 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.0 GO:2000831 corticosteroid hormone secretion(GO:0035930) regulation of steroid hormone secretion(GO:2000831) regulation of corticosteroid hormone secretion(GO:2000846)
0.0 0.1 GO:0036230 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0 0.0 GO:0048539 bone marrow development(GO:0048539)
0.0 0.0 GO:1904251 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0 0.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.2 GO:0031649 heat generation(GO:0031649)
0.0 0.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.3 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.0 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.2 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.0 0.1 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.0 0.1 GO:0070071 proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0 0.1 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.0 GO:0060751 branch elongation involved in mammary gland duct branching(GO:0060751)
0.0 0.0 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.0 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.0 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.0 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.0 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.0 GO:0006531 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.0 GO:0003211 cardiac chamber formation(GO:0003207) cardiac ventricle formation(GO:0003211)
0.0 0.0 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.0 GO:0006922 obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0 0.0 GO:1900078 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.3 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 0.0 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.1 GO:0006896 Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.0 GO:0001973 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.0 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.0 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.0 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0061384 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.0 GO:0030202 heparin metabolic process(GO:0030202)
0.0 0.1 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.0 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.0 GO:0051709 regulation of killing of cells of other organism(GO:0051709) positive regulation of killing of cells of other organism(GO:0051712)
0.0 0.1 GO:0000154 rRNA modification(GO:0000154)
0.0 0.0 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.0 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.0 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.0 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.0 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.0 0.0 GO:0009221 pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
0.0 0.0 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.2 GO:0090278 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.0 0.0 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.0 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.1 GO:0043049 otic placode formation(GO:0043049)
0.0 0.0 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.0 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.1 GO:0043247 telomere capping(GO:0016233) protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0 0.1 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.2 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0006553 lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0 0.0 GO:0072070 loop of Henle development(GO:0072070)
0.0 0.0 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.1 GO:0042267 natural killer cell mediated immunity(GO:0002228) natural killer cell mediated cytotoxicity(GO:0042267)
0.0 0.0 GO:0032898 neurotrophin production(GO:0032898)
0.0 0.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.0 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.1 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 0.1 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.0 0.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0034227 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0 0.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.0 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.0 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0 0.0 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.0 0.0 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0050850 positive regulation of calcium-mediated signaling(GO:0050850)
0.0 0.1 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.0 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.0 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.1 GO:0007512 adult heart development(GO:0007512)
0.0 0.3 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 0.0 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
0.0 0.0 GO:0017085 response to insecticide(GO:0017085)
0.0 0.0 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0 0.0 GO:0051665 membrane raft localization(GO:0051665)
0.0 0.0 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.1 GO:0048661 positive regulation of smooth muscle cell proliferation(GO:0048661)
0.0 0.0 GO:0071698 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.0 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.0 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.0 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.0 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 0.1 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.0 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.0 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.0 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0 0.0 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.1 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.0 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.0 GO:0070295 renal water absorption(GO:0070295)
0.0 0.0 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.0 GO:0002544 chronic inflammatory response(GO:0002544)
0.0 0.0 GO:0035284 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.0 GO:0048261 negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0 0.0 GO:0022417 protein maturation by protein folding(GO:0022417)
0.0 0.1 GO:0002639 positive regulation of immunoglobulin production(GO:0002639)
0.0 0.1 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.0 GO:0002347 response to tumor cell(GO:0002347)
0.0 0.0 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0 0.0 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.0 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.0 0.0 GO:0048520 positive regulation of behavior(GO:0048520)
0.0 0.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.0 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.0 GO:0042416 dopamine biosynthetic process(GO:0042416)
0.0 0.1 GO:0018065 protein-cofactor linkage(GO:0018065)
0.0 0.1 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.0 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.2 GO:0031904 endosome lumen(GO:0031904)
0.1 0.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.1 0.3 GO:0031082 BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.1 0.2 GO:0032009 early phagosome(GO:0032009)
0.0 0.3 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.4 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.3 GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0002139 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.5 GO:0032420 stereocilium(GO:0032420)
0.0 0.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.1 GO:0045240 dihydrolipoyl dehydrogenase complex(GO:0045240)
0.0 0.1 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.0 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.2 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.1 GO:0000791 euchromatin(GO:0000791)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 2.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.2 GO:0031094 platelet dense tubular network(GO:0031094)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.2 GO:0030914 STAGA complex(GO:0030914)
0.0 0.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.0 GO:0000125 PCAF complex(GO:0000125)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.0 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.0 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.0 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.0 GO:0044462 external encapsulating structure(GO:0030312) external encapsulating structure part(GO:0044462)
0.0 0.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.1 GO:0042588 zymogen granule(GO:0042588)
0.0 0.1 GO:0071546 pi-body(GO:0071546)
0.0 0.0 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 GO:0019959 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.1 0.4 GO:0001159 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1 0.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.3 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.3 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.4 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 0.7 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 0.2 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.2 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.1 0.2 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.1 0.3 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.2 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.1 0.2 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.2 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.1 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 0.1 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.1 0.2 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.1 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.0 0.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.1 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.0 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.0 0.4 GO:0019864 IgG binding(GO:0019864)
0.0 0.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0035197 siRNA binding(GO:0035197)
0.0 0.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.1 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 1.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.7 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.3 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.0 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.4 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.6 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.2 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.2 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.4 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.0 0.1 GO:0004739 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.2 GO:0052743 inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0 0.2 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.3 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.1 GO:0004476 mannose-6-phosphate isomerase activity(GO:0004476)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.3 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.3 GO:0060590 ATPase regulator activity(GO:0060590)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.4 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.1 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.1 GO:0001846 opsonin binding(GO:0001846)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.2 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.0 0.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.0 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0016421 CoA carboxylase activity(GO:0016421)
0.0 0.2 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.1 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.3 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.1 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.2 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.1 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.2 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.2 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.0 GO:0071723 lipopeptide binding(GO:0071723)
0.0 0.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.1 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.5 GO:0003823 antigen binding(GO:0003823)
0.0 0.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.1 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.5 GO:0051087 chaperone binding(GO:0051087)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0051378 serotonin binding(GO:0051378)
0.0 0.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 1.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.0 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.0 GO:0034187 obsolete apolipoprotein E binding(GO:0034187)
0.0 0.0 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.1 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.0 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.0 0.4 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 0.0 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 0.0 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.0 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.0 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.1 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.0 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.0 GO:0015645 fatty acid ligase activity(GO:0015645)
0.0 0.0 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.0 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0016208 AMP binding(GO:0016208)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.0 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.0 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.0 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.1 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.0 GO:0005415 nucleoside:sodium symporter activity(GO:0005415)
0.0 0.0 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.0 0.0 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.0 GO:0004946 bombesin receptor activity(GO:0004946)
0.0 0.0 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.0 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:0016917 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.0 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.5 GO:0008009 chemokine activity(GO:0008009)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 0.1 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 0.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.7 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.2 PID EPO PATHWAY EPO signaling pathway
0.0 0.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 1.3 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.7 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.1 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.4 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.5 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.2 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.4 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 0.5 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.4 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.1 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.1 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.3 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.1 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.3 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.1 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 0.7 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 0.1 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.1 0.1 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 0.1 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.1 0.4 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.2 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.0 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.0 0.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.0 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.4 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.1 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.0 0.4 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.0 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 0.1 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.1 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.1 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.1 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.5 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.0 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.0 0.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 1.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.1 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.1 REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.1 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.2 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.1 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.0 0.2 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.0 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.2 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.1 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.0 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.0 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 0.0 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.1 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 0.2 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.1 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.2 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.0 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.1 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.0 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.1 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.2 REACTOME IL 3 5 AND GM CSF SIGNALING Genes involved in Interleukin-3, 5 and GM-CSF signaling