Project
ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for FOXC1

Z-value: 1.37

Motif logo

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Transcription factors associated with FOXC1

Gene Symbol Gene ID Gene Info
FOXC1
ENSG00000054598.5 FOXC1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
FOXC1chr6_1703338_1703561927680.0945340.872.5e-03Click!
FOXC1chr6_1575832_1575983347740.2093410.863.2e-03Click!
FOXC1chr6_1686574_1686725759680.1219590.853.8e-03Click!
FOXC1chr6_1772728_17728791621220.039404-0.817.7e-03Click!
FOXC1chr6_1698536_1698687879300.1015920.808.9e-03Click!

Activity of the FOXC1 motif across conditions

Conditions sorted by the z-value of the FOXC1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr4_157242892_157243172 0.73 ENSG00000221189
 .
 25234
 0.27
chr10_95507444_95507712 0.72 LGI1
 leucine-rich, glioma inactivated 1
 9988
 0.23
chr19_18575570_18575881 0.71 ELL
 elongation factor RNA polymerase II
 11018
 0.1
chr1_40358181_40358689 0.70 RP1-118J21.5
4982
 0.14
chr20_36904040_36904191 0.69 KIAA1755
 KIAA1755
 14941
 0.15
chr20_47448190_47448648 0.68 PREX1
 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
 3999
 0.32
chr2_12959099_12960371 0.67 ENSG00000264370
 .
 82242
 0.11
chr8_126536876_126537027 0.67 ENSG00000266452
 .
 80144
 0.1
chr18_61497949_61498456 0.66 SERPINB2
 serpin peptidase inhibitor, clade B (ovalbumin), member 2
 40724
 0.14
chr18_457195_458136 0.66 RP11-720L2.2
33249
 0.16
chr12_66050940_66051359 0.65 HMGA2
 high mobility group AT-hook 2
 166762
 0.03
chr3_119921549_119921940 0.62 ENSG00000206721
 .
 7423
 0.22
chr1_115876554_115876760 0.59 NGF
 nerve growth factor (beta polypeptide)
 4200
 0.3
chr1_205144955_205145106 0.59 DSTYK
 dual serine/threonine and tyrosine protein kinase
 35664
 0.13
chr10_115910998_115911149 0.58 C10orf118
 chromosome 10 open reading frame 118
 6712
 0.18
chr4_103583867_103584018 0.58 NFKB1
 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
 84921
 0.08
chr13_44811098_44811768 0.58 SMIM2
 small integral membrane protein 2
 76040
 0.1
chr12_65700883_65701407 0.57 MSRB3
 methionine sulfoxide reductase B3
 19510
 0.22
chr5_121462821_121463158 0.56 ZNF474
 zinc finger protein 474
 2219
 0.3
chr8_131377178_131377403 0.56 ASAP1
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
 21833
 0.28
chr4_157700822_157700973 0.55 RP11-154F14.2
61614
 0.13
chr5_77797186_77797364 0.55 LHFPL2
 lipoma HMGIC fusion partner-like 2
 47699
 0.18
chr19_6745452_6745603 0.55 TRIP10
 thyroid hormone receptor interactor 10
 4598
 0.13
chr1_159852066_159852217 0.55 RP11-190A12.8
15397
 0.08
chr11_36178088_36178239 0.55 COMMD9
 COMM domain containing 9
 132811
 0.05
chr1_225942912_225943116 0.54 ENSG00000223306
 .
 14037
 0.14
chr5_65169471_65169622 0.54 ERBB2IP
 erbb2 interacting protein
 52757
 0.14
chr20_52235971_52236462 0.54 ZNF217
 zinc finger protein 217
 10785
 0.21
chr2_29175143_29175407 0.54 FAM179A
 family with sequence similarity 179, member A
 4202
 0.14
chr11_57267439_57267663 0.53 SLC43A1
 solute carrier family 43 (amino acid system L transporter), member 1
 1241
 0.29
chr16_56944713_56945265 0.52 HERPUD1
 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
 20971
 0.1
chr7_79780258_79780623 0.52 GNAI1
 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
 15369
 0.27
chr19_41768990_41769258 0.51 HNRNPUL1
 heterogeneous nuclear ribonucleoprotein U-like 1
 548
 0.66
chr6_110868489_110868770 0.51 CTA-331P3.1
69519
 0.1
chr2_43242041_43242192 0.50 ENSG00000207087
 .
 76516
 0.11
chr7_80261706_80261971 0.50 CD36
 CD36 molecule (thrombospondin receptor)
 6122
 0.33
chr10_88891932_88892287 0.50 RP11-96C23.9
18398
 0.13
chr3_54925868_54926132 0.49 CACNA2D3-AS1
 CACNA2D3 antisense RNA 1
 9282
 0.27
chr11_110634298_110634449 0.49 ARHGAP20
 Rho GTPase activating protein 20
 50461
 0.19
chr13_45769539_45769983 0.48 KCTD4
 potassium channel tetramerization domain containing 4
 909
 0.6
chr1_98403274_98403477 0.48 DPYD
 dihydropyrimidine dehydrogenase
 16770
 0.28
chr11_15919049_15919200 0.48 CTD-3096P4.1
125612
 0.06
chr10_18073243_18073394 0.47 MRC1
 mannose receptor, C type 1
 25034
 0.17
chr15_67803044_67803195 0.47 C15orf61
 chromosome 15 open reading frame 61
 10287
 0.21
chr10_75646701_75646885 0.47 CAMK2G
 calcium/calmodulin-dependent protein kinase II gamma
 12450
 0.12
chr8_119756248_119756399 0.46 SAMD12
 sterile alpha motif domain containing 12
 122089
 0.06
chr1_43760092_43760243 0.46 TIE1
 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
 6497
 0.13
chr6_16676788_16676939 0.46 RP1-151F17.1
84506
 0.1
chr1_6930430_6930581 0.46 CAMTA1
 calmodulin binding transcription activator 1
 84914
 0.08
chr12_116814280_116814431 0.46 ENSG00000264037
 .
 51768
 0.15
chr3_58374430_58375078 0.46 PXK
 PX domain containing serine/threonine kinase
 6647
 0.2
chr18_20960634_20960918 0.45 TMEM241
 transmembrane protein 241
 57041
 0.11
chr10_17826265_17826416 0.45 MRC1L1
 cDNA FLJ56855, highly similar to Macrophage mannose receptor 1
 25022
 0.16
chr9_94908980_94909563 0.45 ENSG00000238996
 .
 1803
 0.38
chr8_96111972_96112794 0.45 RP11-320N21.2
12231
 0.16
chr18_22907594_22907986 0.45 ZNF521
 zinc finger protein 521
 23367
 0.23
chr1_243428429_243428713 0.45 SDCCAG8
 serologically defined colon cancer antigen 8
 9199
 0.19
chr13_41639007_41639306 0.44 WBP4
 WW domain binding protein 4
 3460
 0.19
chr11_5627634_5627785 0.44 TRIM6
 tripartite motif containing 6
 9673
 0.1
chr18_60905822_60905974 0.44 ENSG00000238988
 .
 44000
 0.14
chr5_88851937_88852088 0.44 MEF2C-AS1
 MEF2C antisense RNA 1
 137388
 0.05
chr9_117439245_117439536 0.44 ENSG00000272241
 .
 60563
 0.1
chr12_46796862_46797190 0.44 SLC38A2
 solute carrier family 38, member 2
 30376
 0.2
chr1_98315176_98315780 0.44 DPYD-AS2
 DPYD antisense RNA 2
 52957
 0.16
chr3_188390892_188391164 0.44 ENSG00000207651
 .
 15541
 0.22
chr22_30578717_30578868 0.43 RP3-438O4.4
24306
 0.13
chr11_34449252_34449782 0.43 CAT
 catalase
 10955
 0.23
chr20_5627905_5628088 0.43 GPCPD1
 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
 36324
 0.2
chr11_100720535_100720686 0.43 ENSG00000200047
 .
 10249
 0.23
chr9_86126228_86126614 0.43 FRMD3
 FERM domain containing 3
 26932
 0.16
chr16_11143336_11143487 0.43 RP11-66H6.3
21548
 0.18
chr5_93553629_93553780 0.42 FAM172A
 family with sequence similarity 172, member A
 106323
 0.08
chr5_133927870_133928021 0.42 SAR1B
 SAR1 homolog B (S. cerevisiae)
 20831
 0.15
chr2_72450802_72450953 0.42 CYP26B1
 cytochrome P450, family 26, subfamily B, polypeptide 1
 75710
 0.13
chr6_164530035_164530217 0.42 ENSG00000266128
 .
 268533
 0.02
chrX_136134760_136135069 0.42 GPR101
 G protein-coupled receptor 101
 21081
 0.24
chr5_115789878_115790274 0.42 CTB-118N6.3
4650
 0.26
chr7_23512466_23512617 0.42 IGF2BP3
 insulin-like growth factor 2 mRNA binding protein 3
 2455
 0.25
chr2_75052279_75052565 0.42 HK2
 hexokinase 2
 8686
 0.26
chr4_148694501_148694652 0.41 ENSG00000264274
 .
 9170
 0.18
chr15_77695649_77695800 0.41 PEAK1
 pseudopodium-enriched atypical kinase 1
 16718
 0.22
chr6_37028055_37028341 0.41 COX6A1P2
 cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
 15591
 0.19
chr21_46550357_46550680 0.41 ADARB1
 adenosine deaminase, RNA-specific, B1
 9703
 0.16
chr6_2631111_2631262 0.41 C6orf195
 chromosome 6 open reading frame 195
 3651
 0.34
chr2_144711401_144711552 0.40 AC016910.1
16836
 0.25
chr3_78694842_78694993 0.40 ROBO1
 roundabout, axon guidance receptor, homolog 1 (Drosophila)
 11187
 0.32
chr3_37156478_37156973 0.40 ENSG00000206645
 .
 22000
 0.14
chr14_78060038_78060870 0.40 SPTLC2
 serine palmitoyltransferase, long chain base subunit 2
 3210
 0.25
chr10_105595246_105595397 0.40 SH3PXD2A
 SH3 and PX domains 2A
 19843
 0.19
chr15_100584069_100584220 0.40 ENSG00000252957
 .
 30251
 0.17
chr11_86884640_86884791 0.40 TMEM135
 transmembrane protein 135
 135633
 0.05
chr2_226983007_226983256 0.39 ENSG00000263363
 .
 540378
 0.0
chr8_19045527_19045678 0.39 PSD3
 pleckstrin and Sec7 domain containing 3
 103362
 0.08
chr11_86355699_86355850 0.39 ME3
 malic enzyme 3, NADP(+)-dependent, mitochondrial
 27466
 0.25
chr6_72188929_72189086 0.39 ENSG00000212099
 .
 59672
 0.12
chr7_41909334_41909592 0.39 AC005027.3
164530
 0.04
chr4_40623166_40623743 0.39 RBM47
 RNA binding motif protein 47
 8427
 0.27
chr15_59461940_59462091 0.38 ENSG00000253030
 .
 1446
 0.28
chr8_119427422_119427697 0.38 AC023590.1
 Uncharacterized protein
 133078
 0.05
chr16_70779927_70780078 0.38 RP11-394B2.6
958
 0.42
chr14_68454710_68454913 0.38 CTD-2566J3.1
142102
 0.04
chr6_56406545_56407042 0.38 DST
 dystonin
 68005
 0.13
chr12_29895057_29895338 0.38 TMTC1
 transmembrane and tetratricopeptide repeat containing 1
 41534
 0.21
chr4_22515546_22516022 0.38 GPR125
 G protein-coupled receptor 125
 1836
 0.52
chr1_234630412_234630563 0.38 TARBP1
 TAR (HIV-1) RNA binding protein 1
 15638
 0.21
chr2_13118868_13119112 0.38 ENSG00000264370
 .
 241497
 0.02
chr1_64292995_64293146 0.38 ROR1
 receptor tyrosine kinase-like orphan receptor 1
 53356
 0.16
chr11_69084536_69085027 0.37 MYEOV
 myeloma overexpressed
 23156
 0.25
chr11_44257214_44257365 0.37 ALX4
 ALX homeobox 4
 74427
 0.11
chr12_52182216_52182367 0.37 AC068987.1
 HCG1997999; cDNA FLJ33996 fis, clone DFNES2008881
 21498
 0.2
chr11_126788047_126788198 0.37 KIRREL3-AS2
 KIRREL3 antisense RNA 2
 22520
 0.2
chr9_18638757_18638908 0.37 ENSG00000252960
 .
 12313
 0.27
chr6_112366386_112366743 0.37 WISP3
 WNT1 inducible signaling pathway protein 3
 8711
 0.21
chr19_56059176_56059327 0.37 SBK3
 SH3 domain binding kinase family, member 3
 2342
 0.14
chr3_11278939_11279235 0.37 HRH1
 histamine receptor H1
 11370
 0.25
chr16_17266652_17267123 0.37 CTD-2576D5.4
38526
 0.23
chr13_37018901_37019079 0.37 CCNA1
 cyclin A1
 12495
 0.23
chr3_11279617_11279863 0.37 HRH1
 histamine receptor H1
 12023
 0.25
chr1_172872813_172873091 0.37 TNFSF18
 tumor necrosis factor (ligand) superfamily, member 18
 147104
 0.04
chr20_32922542_32922693 0.36 AHCY
 adenosylhomocysteinase
 23009
 0.13
chr5_36367141_36367292 0.36 RANBP3L
 RAN binding protein 3-like
 65000
 0.12
chr8_120553418_120553569 0.36 ENPP2
 ectonucleotide pyrophosphatase/phosphodiesterase 2
 51755
 0.15
chr14_54360916_54361067 0.36 ENSG00000266431
 .
 54211
 0.16
chr7_1555587_1555854 0.36 AC102953.6
6657
 0.14
chr3_149274344_149274603 0.36 WWTR1
 WW domain containing transcription regulator 1
 19566
 0.18
chr1_39608036_39608283 0.36 ENSG00000222378
 .
 11809
 0.17
chr6_140053583_140053734 0.36 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 357901
 0.01
chr1_181047325_181047476 0.36 IER5
 immediate early response 5
 10238
 0.21
chr4_83992439_83992590 0.36 COPS4
 COP9 signalosome subunit 4
 36136
 0.14
chr13_32520415_32520566 0.36 EEF1DP3
 eukaryotic translation elongation factor 1 delta pseudogene 3
 6227
 0.29
chr13_111062611_111062762 0.36 ENSG00000238629
 .
 3866
 0.28
chr2_145252336_145252641 0.36 ZEB2
 zinc finger E-box binding homeobox 2
 22627
 0.22
chr2_174862628_174862955 0.36 SP3
 Sp3 transcription factor
 32361
 0.24
chr12_46949120_46949271 0.36 SLC38A2
 solute carrier family 38, member 2
 182545
 0.03
chr3_114225823_114225974 0.36 ZBTB20
 zinc finger and BTB domain containing 20
 52234
 0.16
chr2_216400648_216400799 0.36 AC012462.1
99747
 0.08
chr12_96866193_96866344 0.35 C12orf55
 chromosome 12 open reading frame 55
 17085
 0.19
chr12_57542255_57543089 0.35 RP11-545N8.3
1270
 0.29
chr1_161762804_161762955 0.35 ATF6
 activating transcription factor 6
 26795
 0.12
chr8_48523757_48523908 0.35 SPIDR
 scaffolding protein involved in DNA repair
 48394
 0.14
chr4_19750489_19750640 0.35 SLIT2
 slit homolog 2 (Drosophila)
 504319
 0.0
chr9_16626415_16626566 0.35 RP11-62F24.1
816
 0.74
chr10_131926285_131926436 0.35 GLRX3
 glutaredoxin 3
 8303
 0.32
chr10_51573717_51573868 0.35 NCOA4
 nuclear receptor coactivator 4
 492
 0.79
chr8_98963963_98964114 0.35 MATN2
 matrilin 2
 1071
 0.57
chr9_22683470_22683621 0.35 DMRTA1
 DMRT-like family A1
 236705
 0.02
chr5_71426364_71426515 0.35 MAP1B
 microtubule-associated protein 1B
 23126
 0.22
chr20_52353487_52354058 0.35 ENSG00000238468
 .
 68475
 0.12
chr20_18205406_18205557 0.35 ENSG00000266720
 .
 34014
 0.11
chr2_20503901_20504052 0.35 PUM2
 pumilio RNA-binding family member 2
 8041
 0.2
chr9_124716545_124716696 0.35 RP11-244O19.1
134889
 0.04
chr6_148852882_148853033 0.35 ENSG00000223322
 .
 7581
 0.32
chr13_37362298_37362449 0.35 RFXAP
 regulatory factor X-associated protein
 30988
 0.17
chr21_30620651_30620953 0.34 BACH1
 BTB and CNC homology 1, basic leucine zipper transcription factor 1
 50390
 0.1
chr3_149865923_149866214 0.34 RP11-167H9.4
50249
 0.14
chr7_114563503_114563973 0.34 MDFIC
 MyoD family inhibitor domain containing
 607
 0.85
chr16_71916526_71917374 0.34 ZNF821
 zinc finger protein 821
 462
 0.56
chr2_44347955_44348155 0.34 ENSG00000252599
 .
 33979
 0.16
chr19_11454879_11455424 0.34 CCDC159
 coiled-coil domain containing 159
 826
 0.33
chr8_62632405_62632737 0.34 ENSG00000264408
 .
 5224
 0.25
chr14_80050698_80050849 0.34 RP11-242P2.2
48881
 0.19
chr2_206411815_206412034 0.34 NRP2
 neuropilin 2
 135300
 0.05
chr15_42119496_42120104 0.34 RP11-23P13.4
253
 0.47
chr6_12608393_12608818 0.34 PHACTR1
 phosphatase and actin regulator 1
 109288
 0.07
chr11_122009054_122009205 0.34 ENSG00000198975
 .
 8172
 0.16
chr10_104573498_104574150 0.34 ENSG00000252994
 .
 10138
 0.12
chr6_139868425_139868726 0.34 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 172818
 0.03
chr7_95064533_95064791 0.34 PON2
 paraoxonase 2
 152
 0.95
chr2_144854247_144854398 0.34 GTDC1
 glycosyltransferase-like domain containing 1
 138982
 0.05
chr20_19795785_19795937 0.34 AL121761.2
 Uncharacterized protein
 57182
 0.12
chr16_29547755_29547906 0.34 ENSG00000239193
 .
 2856
 0.19
chr6_81348783_81348934 0.34 BCKDHB
 branched chain keto acid dehydrogenase E1, beta polypeptide
 532475
 0.0
chr14_68466602_68466753 0.34 CTD-2566J3.1
130236
 0.05
chr4_54408278_54408429 0.34 LNX1
 ligand of numb-protein X 1, E3 ubiquitin protein ligase
 16031
 0.2
chr6_157737936_157738117 0.34 TMEM242
 transmembrane protein 242
 6607
 0.24
chr22_24879293_24879554 0.34 ADORA2A-AS1
 ADORA2A antisense RNA 1
 11340
 0.14
chr12_77626070_77626221 0.34 ENSG00000238769
 .
 69340
 0.14
chr7_40713134_40713414 0.34 AC005160.3
101883
 0.08
chr12_91533860_91534011 0.34 DCN
 decorin
 6050
 0.26
chr16_14653487_14653730 0.34 ENSG00000242430
 .
 42343
 0.12
chr9_136423569_136424056 0.34 FAM163B
 family with sequence similarity 163, member B
 21556
 0.12
chr11_12699502_12699653 0.34 TEAD1
 TEA domain family member 1 (SV40 transcriptional enhancer factor)
 2527
 0.41
chr4_81158071_81158222 0.34 FGF5
 fibroblast growth factor 5
 29607
 0.18
chr9_4144869_4145020 0.33 GLIS3
 GLIS family zinc finger 3
 249
 0.95
chr10_129076543_129076694 0.33 FAM196A
 family with sequence similarity 196, member A
 82196
 0.11
chr3_135794639_135794790 0.33 RP11-305O4.3
12041
 0.25
chr4_56049873_56050024 0.33 ENSG00000239545
 .
 32131
 0.17
chr1_39678600_39678751 0.33 RP11-416A14.1
6491
 0.18
chr21_28944974_28945125 0.33 ADAMTS5
 ADAM metallopeptidase with thrombospondin type 1 motif, 5
 606217
 0.0
chr21_27777769_27777920 0.33 AP001597.1
418
 0.88
chr7_100782348_100782499 0.33 SERPINE1
 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
 12044
 0.1
chr6_116685228_116685657 0.33 DSE
 dermatan sulfate epimerase
 5568
 0.22
chr3_175149023_175149174 0.33 ENSG00000199792
 .
 33961
 0.21
chr3_99832344_99832495 0.33 FILIP1L
 filamin A interacting protein 1-like
 938
 0.47
chr17_28181951_28182102 0.33 RP11-338L22.2
8394
 0.15
chr20_10450434_10450690 0.33 SLX4IP
 SLX4 interacting protein
 34611
 0.17
chr3_188374207_188374358 0.33 ENSG00000264114
 .
 25792
 0.18
chr2_174016293_174016444 0.33 MLK7-AS1
 MLK7 antisense RNA 1
 55972
 0.13
chr7_133331165_133331316 0.33 EXOC4
 exocyst complex component 4
 70024
 0.14
chr13_21654358_21654593 0.33 LATS2
 large tumor suppressor kinase 2
 18789
 0.14

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of FOXC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1 0.3 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.1 0.1 GO:0048669 collateral sprouting in absence of injury(GO:0048669)
0.1 0.3 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.1 0.2 GO:0030091 protein repair(GO:0030091)
0.1 0.4 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 0.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 0.3 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.2 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.1 0.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.1 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.1 0.2 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.2 GO:0032455 nerve growth factor processing(GO:0032455)
0.1 0.2 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 0.3 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1 0.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.2 GO:0045056 transcytosis(GO:0045056)
0.0 0.3 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0001821 histamine secretion(GO:0001821)
0.0 0.1 GO:2000008 regulation of protein localization to cell surface(GO:2000008)
0.0 0.0 GO:0072191 positive regulation of smooth muscle cell differentiation(GO:0051152) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0 0.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:0034653 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.3 GO:0061001 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.0 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.0 0.1 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.0 0.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 0.2 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.1 GO:0060737 prostate gland morphogenetic growth(GO:0060737)
0.0 0.0 GO:2000043 negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.0 0.1 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.2 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.1 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0003010 voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0 0.1 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.0 0.0 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.4 GO:0050922 negative regulation of chemotaxis(GO:0050922)
0.0 0.1 GO:0016081 synaptic vesicle docking(GO:0016081)
0.0 0.1 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0 0.1 GO:1903170 negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0 0.1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0018243 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.1 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.0 0.1 GO:0090085 regulation of protein deubiquitination(GO:0090085)
0.0 0.1 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.1 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.3 GO:0009629 response to gravity(GO:0009629)
0.0 0.1 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.1 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.0 GO:0002885 positive regulation of hypersensitivity(GO:0002885)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:0009128 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.1 GO:0060594 mammary gland specification(GO:0060594)
0.0 0.2 GO:0042119 neutrophil activation(GO:0042119)
0.0 0.3 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0 0.1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0035608 protein deglutamylation(GO:0035608)
0.0 0.1 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.1 GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0 0.1 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.1 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.1 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.1 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.0 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.0 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101)
0.0 0.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.0 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0006448 regulation of translational elongation(GO:0006448)
0.0 0.1 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.3 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.3 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.0 GO:0060687 regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0 0.1 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:0034625 fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0 0.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.0 GO:0060174 limb bud formation(GO:0060174)
0.0 0.1 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.0 GO:0048263 determination of dorsal/ventral asymmetry(GO:0048262) determination of dorsal identity(GO:0048263)
0.0 0.1 GO:0097435 extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0 0.1 GO:0032717 negative regulation of interleukin-8 production(GO:0032717)
0.0 0.1 GO:0097094 cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0 0.1 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0 0.1 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.4 GO:0061641 DNA replication-independent nucleosome assembly(GO:0006336) CENP-A containing nucleosome assembly(GO:0034080) DNA replication-independent nucleosome organization(GO:0034724) CENP-A containing chromatin organization(GO:0061641)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.2 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.2 GO:0007567 parturition(GO:0007567)
0.0 0.2 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.0 0.1 GO:0006573 valine metabolic process(GO:0006573)
0.0 0.1 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.1 GO:2001280 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0016553 base conversion or substitution editing(GO:0016553)
0.0 0.1 GO:0043306 positive regulation of myeloid leukocyte mediated immunity(GO:0002888) positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.0 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.1 GO:0006983 ER overload response(GO:0006983)
0.0 0.0 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.0 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.1 GO:2000757 negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0 0.0 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.2 GO:0006693 prostaglandin metabolic process(GO:0006693)
0.0 0.1 GO:0001967 suckling behavior(GO:0001967)
0.0 0.1 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.0 GO:0051136 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.1 GO:1904478 regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.0 0.2 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.0 GO:0043486 histone exchange(GO:0043486)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.0 GO:0010875 positive regulation of cholesterol efflux(GO:0010875)
0.0 0.4 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 0.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.1 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.0 GO:0072124 glomerular mesangial cell proliferation(GO:0072110) regulation of glomerular mesangial cell proliferation(GO:0072124)
0.0 0.0 GO:0033133 regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.0 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.1 GO:0010611 regulation of cardiac muscle hypertrophy(GO:0010611)
0.0 0.0 GO:1902624 positive regulation of neutrophil chemotaxis(GO:0090023) positive regulation of neutrophil migration(GO:1902624)
0.0 0.0 GO:0045992 negative regulation of embryonic development(GO:0045992)
0.0 0.0 GO:0060192 negative regulation of lipase activity(GO:0060192)
0.0 0.1 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.1 GO:0001569 patterning of blood vessels(GO:0001569)
0.0 0.1 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.0 GO:0060433 bronchus development(GO:0060433)
0.0 0.2 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.0 0.0 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.0 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.0 GO:0060033 anatomical structure regression(GO:0060033)
0.0 0.4 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.0 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.0 GO:0033630 positive regulation of cell adhesion mediated by integrin(GO:0033630)
0.0 0.0 GO:0044415 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.2 GO:0001755 neural crest cell migration(GO:0001755)
0.0 0.1 GO:0090114 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.0 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.0 GO:0046469 platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0 0.0 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.0 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.2 GO:0042762 regulation of sulfur metabolic process(GO:0042762)
0.0 0.0 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.0 GO:0001757 somite specification(GO:0001757)
0.0 0.0 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0016246 RNA interference(GO:0016246)
0.0 0.0 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.2 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.0 0.0 GO:0002093 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.0 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
0.0 0.0 GO:0048293 isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0 0.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.0 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.1 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.1 GO:0015840 urea transport(GO:0015840)
0.0 0.0 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 0.0 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.0 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.0 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.0 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.0 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.1 GO:2000144 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.1 GO:0001542 ovulation from ovarian follicle(GO:0001542)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0016600 flotillin complex(GO:0016600)
0.1 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.2 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0002142 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.2 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.0 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.3 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.1 GO:0071546 pi-body(GO:0071546)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.0 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0031430 M band(GO:0031430)
0.0 0.0 GO:1903561 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.0 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.1 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.0 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.2 GO:0030530 obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0 0.1 GO:0099738 cell cortex region(GO:0099738)
0.0 0.1 GO:0005581 collagen trimer(GO:0005581)
0.0 0.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.6 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.0 GO:0000800 lateral element(GO:0000800)
0.0 0.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.0 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.1 GO:0043256 laminin complex(GO:0043256)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001159 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1 0.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.3 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 0.3 GO:0004064 arylesterase activity(GO:0004064)
0.1 0.3 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 0.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 0.5 GO:0051636 obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.1 0.2 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.2 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1 0.2 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0005534 galactose binding(GO:0005534)
0.0 0.2 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.2 GO:0032052 bile acid binding(GO:0032052)
0.0 0.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.2 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.1 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.1 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.2 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.2 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.2 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.2 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.3 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.1 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.0 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.0 0.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.1 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.0 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0005123 death receptor binding(GO:0005123)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.2 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.1 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0043734 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.1 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.0 0.1 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.0 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.0 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.0 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.0 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.1 GO:0045502 dynein binding(GO:0045502)
0.0 0.1 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.0 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.0 GO:0004739 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.0 GO:0050542 icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.0 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.0 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.0 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.4 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.1 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.0 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.0 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.1 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.0 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.0 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0009922 fatty acid elongase activity(GO:0009922)
0.0 0.1 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0 0.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.0 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.0 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.0 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.0 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.0 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.0 PID MYC PATHWAY C-MYC pathway
0.0 0.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.5 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.1 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.0 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.8 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 0.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.0 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.1 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.4 PID FOXO PATHWAY FoxO family signaling
0.0 0.1 PID IL3 PATHWAY IL3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.0 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.0 0.1 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.2 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.2 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.2 REACTOME GABA B RECEPTOR ACTIVATION Genes involved in GABA B receptor activation
0.0 0.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.1 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.1 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.2 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.0 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.2 REACTOME GRB2 EVENTS IN ERBB2 SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.0 0.1 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions