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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for FOXN1
Z-value: 4.65
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Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:
This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.
For each TF, only the top 5 correlated CREs are shown.
| CRE | Gene | Distance | Association probability | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|---|---|
| chr17_26832603_26832754 | FOXN1 | 583 | 0.592674 | 0.34 | 3.8e-01 | Click! |
| chr17_26832783_26832934 | FOXN1 | 403 | 0.733010 | 0.29 | 4.4e-01 | Click! |
| chr17_26837102_26837253 | FOXN1 | 3899 | 0.121284 | 0.38 | 3.1e-01 | Click! |
| chr17_26837711_26837862 | FOXN1 | 4508 | 0.114688 | 0.30 | 4.3e-01 | Click! |
| chr17_26846701_26846852 | FOXN1 | 4183 | 0.113017 | 0.36 | 3.4e-01 | Click! |
Showing 1 to 5 of 5 entries
Top target CREs of the motif:
| Cis Regulatory Element (CRE) | Target Score | Top associated gene | Gene Info | Distance of CRE to TSS | CRE/Gene association probability |
|---|---|---|---|---|---|
| chr9_102584698_102584849 | 1.76 |
NR4A3 |
nuclear receptor subfamily 4, group A, member 3 |
636 |
0.8 |
| chr15_91362346_91362739 | 1.74 |
CTD-3094K11.1 |
|
20412 |
0.12 |
| chr17_800175_800326 | 1.65 |
RP11-676J12.7 |
Uncharacterized protein |
12622 |
0.15 |
| chr17_43226129_43226446 | 1.64 |
HEXIM1 |
hexamethylene bis-acetamide inducible 1 |
1603 |
0.22 |
| chr21_34961114_34961265 | 1.63 |
DONSON |
downstream neighbor of SON |
175 |
0.93 |
| chr6_3157097_3157483 | 1.47 |
TUBB2A |
tubulin, beta 2A class IIa |
470 |
0.75 |
| chr1_160231794_160231945 | 1.40 |
DCAF8 |
DDB1 and CUL4 associated factor 8 |
277 |
0.53 |
| chr7_66205180_66205331 | 1.30 |
RP11-792A8.4 |
|
117 |
0.71 |
| chr6_4135230_4135381 | 1.19 |
RP3-400B16.4 |
|
352 |
0.51 |
| chr2_237993953_237994237 | 1.18 |
COPS8 |
COP9 signalosome subunit 8 |
140 |
0.76 |
Histogram of CRE-TSS distances for CREs targeted by :
Rank distribution of CRE target scores:
Distribution of target CREs across different genomic regions:
Network of associatons between targets according to the STRING database.
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 0.0 | 3.3 | GO:0007249 | I-kappaB kinase/NF-kappaB signaling(GO:0007249) |
| 0.0 | 2.1 | GO:0006417 | regulation of translation(GO:0006417) |
| 0.1 | 1.7 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 1.6 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.1 | 1.4 | GO:0031572 | G2 DNA damage checkpoint(GO:0031572) |
| 0.0 | 1.4 | GO:0051084 | 'de novo' posttranslational protein folding(GO:0051084) |
| 0.0 | 1.4 | GO:0006470 | protein dephosphorylation(GO:0006470) |
| 0.3 | 1.3 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 0.1 | 1.3 | GO:0046697 | decidualization(GO:0046697) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 42.8 | GO:0005634 | nucleus(GO:0005634) |
| 0.0 | 13.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 8.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 5.2 | GO:0005625 | obsolete soluble fraction(GO:0005625) |
| 0.0 | 5.0 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 3.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 2.3 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 2.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 2.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 2.1 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.2 | GO:0003677 | DNA binding(GO:0003677) |
| 0.0 | 10.7 | GO:0003700 | transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 4.3 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 3.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 3.0 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 2.5 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 2.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 2.2 | GO:0016566 | obsolete specific transcriptional repressor activity(GO:0016566) |
| 0.0 | 2.1 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 1.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 2.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 2.3 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 2.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 1.9 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 1.9 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 1.8 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 1.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.5 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 1.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 2.6 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 2.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.9 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 1.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 1.6 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.6 | REACTOME MITOTIC M M G1 PHASES | Genes involved in Mitotic M-M/G1 phases |
| 0.1 | 1.4 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 1.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |