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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for FOXO3_FOXD2

Z-value: 0.73

Motif logo

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Transcription factors associated with FOXO3_FOXD2

Gene Symbol Gene ID Gene Info
FOXO3
ENSG00000118689.10 forkhead box O3
FOXD2
ENSG00000186564.5 forkhead box D2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr1_47905796_47905947FOXD241820.177170-0.781.3e-02Click!
chr1_47903924_47904075FOXD223100.2329510.627.6e-02Click!
chr1_47902342_47903033FOXD29980.4522270.571.1e-01Click!
chr1_47906249_47906400FOXD246350.172242-0.561.2e-01Click!
chr1_47909973_47910124FOXD283590.156738-0.531.5e-01Click!
chr6_108994454_108994605FOXO3169800.2754500.891.5e-03Click!
chr6_108885127_108885278FOXO331330.374122-0.881.7e-03Click!
chr6_108949983_108950134FOXO3274910.245271-0.835.3e-03Click!
chr6_108948593_108948758FOXO3288740.240811-0.817.6e-03Click!
chr6_108917705_108917856FOXO3357110.2176560.761.7e-02Click!

Activity of the FOXO3_FOXD2 motif across conditions

Conditions sorted by the z-value of the FOXO3_FOXD2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chrX_9389371_9389522 0.59 TBL1X
 transducin (beta)-like 1X-linked
 41889
 0.22
chr22_24879125_24879276 0.53 ADORA2A-AS1
 ADORA2A antisense RNA 1
 11563
 0.14
chr3_191073989_191074140 0.51 UTS2B
 urotensin 2B
 25739
 0.19
chr14_91488374_91488965 0.40 RPS6KA5
 ribosomal protein S6 kinase, 90kDa, polypeptide 5
 37809
 0.15
chr3_133967811_133967962 0.39 RYK
 receptor-like tyrosine kinase
 1551
 0.52
chr11_10877596_10878299 0.38 ZBED5
 zinc finger, BED-type containing 5
 1237
 0.37
chr19_23437287_23437525 0.37 ZNF724P
 zinc finger protein 724, pseudogene
 4214
 0.29
chr13_33803306_33803457 0.36 STARD13
 StAR-related lipid transfer (START) domain containing 13
 23238
 0.2
chr14_61244389_61244540 0.36 MNAT1
 MNAT CDK-activating kinase assembly factor 1
 30578
 0.19
chr19_34724106_34724375 0.33 KIAA0355
 KIAA0355
 21202
 0.21
chr1_152415265_152415416 0.32 CRNN
 cornulin
 28601
 0.13
chr5_150153974_150154288 0.32 SMIM3
 small integral membrane protein 3
 3377
 0.19
chr1_185066313_185066464 0.32 TRMT1L
 tRNA methyltransferase 1 homolog (S. cerevisiae)-like
 42304
 0.13
chr2_70008722_70008880 0.31 ANXA4
 annexin A4
 39565
 0.14
chr21_39860193_39860344 0.31 ERG
 v-ets avian erythroblastosis virus E26 oncogene homolog
 10077
 0.31
chr4_5035629_5036207 0.31 CYTL1
 cytokine-like 1
 14719
 0.22
chr5_52627609_52627883 0.31 FST
 follistatin
 148493
 0.04
chr4_1759756_1760086 0.31 TACC3
 transforming, acidic coiled-coil containing protein 3
 29790
 0.12
chr10_99599816_99599967 0.30 GOLGA7B
 golgin A7 family, member B
 10105
 0.18
chr9_109203596_109203848 0.30 ENSG00000200131
 .
 238536
 0.02
chr14_53821474_53821625 0.29 RP11-547D23.1
201477
 0.03
chr6_154614018_154614169 0.29 IPCEF1
 interaction protein for cytohesin exchange factors 1
 37122
 0.22
chr5_37739048_37739199 0.29 ENSG00000206743
 .
 38584
 0.18
chr5_173958937_173959224 0.29 MSX2
 msh homeobox 2
 192456
 0.03
chr6_64516560_64517136 0.29 RP11-59D5__B.2
119
 0.98
chr7_100781001_100781597 0.29 SERPINE1
 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
 10920
 0.1
chr2_28210866_28211683 0.29 ENSG00000265321
 .
 7960
 0.26
chr3_55525759_55525910 0.28 WNT5A
 wingless-type MMTV integration site family, member 5A
 1861
 0.41
chr6_135989503_135989654 0.28 AHI1
 Abelson helper integration site 1
 170664
 0.03
chr8_94342739_94342890 0.28 LINC00535
 long intergenic non-protein coding RNA 535
 37900
 0.19
chr13_40260042_40260269 0.27 ENSG00000264171
 .
 21883
 0.17
chr8_66629977_66630128 0.27 RP11-707M3.3
3039
 0.28
chr4_40157960_40158111 0.27 RP11-395I6.3
10260
 0.19
chr11_12147194_12147407 0.27 MICAL2
 microtubule associated monooxygenase, calponin and LIM domain containing 2
 4278
 0.32
chr11_116741651_116741802 0.27 SIK3-IT1
 SIK3 intronic transcript 1 (non-protein coding)
 19711
 0.11
chr12_66271805_66272278 0.27 RP11-366L20.2
 Uncharacterized protein
 3317
 0.24
chr12_10794215_10794366 0.27 STYK1
 serine/threonine/tyrosine kinase 1
 12053
 0.16
chr1_8728345_8728654 0.27 RERE
 arginine-glutamic acid dipeptide (RE) repeats
 12069
 0.26
chr3_182980866_182981048 0.27 B3GNT5
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
 2133
 0.32
chr4_74702622_74702974 0.27 CXCL6
 chemokine (C-X-C motif) ligand 6
 441
 0.79
chr6_47236614_47236765 0.27 TNFRSF21
 tumor necrosis factor receptor superfamily, member 21
 40952
 0.2
chr3_45576267_45576542 0.27 LARS2-AS1
 LARS2 antisense RNA 1
 25367
 0.18
chr20_22990587_22990738 0.27 RP4-753D10.5
20760
 0.15
chr15_68376694_68376845 0.27 PIAS1
 protein inhibitor of activated STAT, 1
 29855
 0.22
chr19_18575570_18575881 0.26 ELL
 elongation factor RNA polymerase II
 11018
 0.1
chr19_39187756_39187907 0.26 CTB-186G2.4
3585
 0.14
chr1_31870789_31870940 0.26 SERINC2
 serine incorporator 2
 11548
 0.15
chr19_38423275_38423557 0.26 SIPA1L3
 signal-induced proliferation-associated 1 like 3
 25548
 0.15
chr3_58320540_58320691 0.26 PXK
 PX domain containing serine/threonine kinase
 1582
 0.4
chr1_33853388_33853681 0.26 PHC2
 polyhomeotic homolog 2 (Drosophila)
 12340
 0.15
chr6_35568601_35569436 0.26 ENSG00000212579
 .
 50577
 0.1
chr10_3134024_3134295 0.26 PFKP
 phosphofructokinase, platelet
 12757
 0.24
chr16_17566923_17567074 0.26 XYLT1
 xylosyltransferase I
 2260
 0.48
chr2_217051631_217052157 0.26 AC012513.6
72424
 0.09
chr12_6198255_6198797 0.26 ENSG00000240533
 .
 6610
 0.23
chr12_113684408_113684559 0.26 TPCN1
 two pore segment channel 1
 2310
 0.23
chr13_80443621_80443990 0.26 NDFIP2
 Nedd4 family interacting protein 2
 388217
 0.01
chr5_75969089_75969240 0.26 F2R
 coagulation factor II (thrombin) receptor
 42704
 0.11
chr1_185703151_185703455 0.25 HMCN1
 hemicentin 1
 380
 0.92
chr1_234755566_234755985 0.25 IRF2BP2
 interferon regulatory factor 2 binding protein 2
 10504
 0.19
chr15_96898066_96898266 0.25 AC087477.1
 Uncharacterized protein
 6321
 0.18
chr12_124992848_124993269 0.25 NCOR2
 nuclear receptor corepressor 2
 9782
 0.31
chr5_171382567_171382718 0.25 FBXW11
 F-box and WD repeat domain containing 11
 22118
 0.23
chr1_59034555_59034706 0.25 ENSG00000264128
 .
 3026
 0.26
chr6_49293968_49294177 0.25 ENSG00000252457
 .
 18449
 0.26
chr16_4103086_4103844 0.25 RP11-462G12.4
21452
 0.2
chr12_78579294_78579445 0.25 NAV3
 neuron navigator 3
 13487
 0.3
chr1_201463290_201463773 0.25 CSRP1
 cysteine and glycine-rich protein 1
 2170
 0.26
chr19_18491035_18491248 0.25 GDF15
 growth differentiation factor 15
 1839
 0.18
chr5_124895396_124895838 0.25 ENSG00000222107
 .
 208793
 0.03
chr16_83859962_83860113 0.25 HSBP1
 heat shock factor binding protein 1
 18443
 0.15
chr2_192530317_192530468 0.25 NABP1
 nucleic acid binding protein 1
 12470
 0.29
chr9_118403979_118404130 0.25 DEC1
 deleted in esophageal cancer 1
 499957
 0.0
chr2_159955686_159955837 0.25 ENSG00000202029
 .
 72107
 0.11
chr9_108873656_108873902 0.25 TMEM38B
 transmembrane protein 38B
 389811
 0.01
chr5_123646330_123646481 0.25 RP11-436H11.2
418119
 0.01
chr12_89764903_89765288 0.25 DUSP6
 dual specificity phosphatase 6
 18047
 0.24
chr20_1796404_1796650 0.24 SIRPA
 signal-regulatory protein alpha
 78627
 0.09
chr11_10828028_10828469 0.24 EIF4G2
 eukaryotic translation initiation factor 4 gamma, 2
 761
 0.52
chr5_169577969_169578120 0.24 FOXI1
 forkhead box I1
 45127
 0.16
chr16_56404978_56405129 0.24 RP11-441F2.5
17617
 0.13
chr3_197043921_197044177 0.24 DLG1
 discs, large homolog 1 (Drosophila)
 17878
 0.15
chr6_33930401_33930552 0.24 ENSG00000221697
 .
 37352
 0.18
chr7_17246525_17246676 0.24 AC003075.4
74327
 0.11
chr6_56514356_56514539 0.24 DST
 dystonin
 6653
 0.32
chr18_43325991_43326142 0.24 RP11-116O18.3
1114
 0.51
chr4_74863945_74864096 0.24 CXCL5
 chemokine (C-X-C motif) ligand 5
 476
 0.73
chr1_65643796_65643947 0.24 AK4
 adenylate kinase 4
 29985
 0.19
chr3_46607636_46607787 0.24 LRRC2
 leucine rich repeat containing 2
 329
 0.83
chr4_157242892_157243172 0.24 ENSG00000221189
 .
 25234
 0.27
chr7_41046808_41047238 0.24 AC005160.3
231866
 0.02
chr22_45106414_45106589 0.24 ARHGAP8
 Rho GTPase activating protein 8
 8119
 0.19
chr3_130693410_130693561 0.24 ATP2C1
 ATPase, Ca++ transporting, type 2C, member 1
 7253
 0.18
chr8_128919633_128920053 0.24 TMEM75
 transmembrane protein 75
 40748
 0.15
chr7_86783673_86784219 0.24 DMTF1
 cyclin D binding myb-like transcription factor 1
 1999
 0.29
chr2_216658765_216659109 0.24 ENSG00000212055
 .
 84705
 0.1
chr9_107687183_107687334 0.24 RP11-217B7.2
2576
 0.3
chr3_87309504_87309716 0.24 POU1F1
 POU class 1 homeobox 1
 16002
 0.21
chr4_157860965_157861230 0.24 PDGFC
 platelet derived growth factor C
 30958
 0.19
chr1_77980530_77980774 0.24 AK5
 adenylate kinase 5
 17140
 0.22
chr22_30023302_30023509 0.24 NF2
 neurofibromin 2 (merlin)
 23417
 0.14
chr17_45005909_45006060 0.24 GOSR2
 golgi SNAP receptor complex member 2
 5421
 0.17
chr17_60004372_60004770 0.24 INTS2
 integrator complex subunit 2
 216
 0.94
chr1_9498520_9498686 0.24 ENSG00000252956
 .
 766
 0.72
chr12_104274321_104274475 0.24 RP11-650K20.3
 Uncharacterized protein
 39169
 0.1
chr8_134353152_134353303 0.24 NDRG1
 N-myc downstream regulated 1
 38962
 0.2
chr2_45822706_45822857 0.23 SRBD1
 S1 RNA binding domain 1
 15639
 0.21
chr1_168051282_168051433 0.23 GPR161
 G protein-coupled receptor 161
 22810
 0.21
chr17_66449042_66449331 0.23 WIPI1
 WD repeat domain, phosphoinositide interacting 1
 4376
 0.23
chr10_60347392_60347543 0.23 BICC1
 bicaudal C homolog 1 (Drosophila)
 74567
 0.12
chr7_17081811_17082046 0.23 AGR3
 anterior gradient 3
 160317
 0.04
chr6_170535437_170535588 0.23 RP5-1086L22.1
36145
 0.15
chr17_26673764_26673915 0.23 TNFAIP1
 tumor necrosis factor, alpha-induced protein 1 (endothelial)
 6407
 0.07
chrX_9755049_9755347 0.23 SHROOM2
 shroom family member 2
 702
 0.51
chr2_174055819_174055970 0.23 MLK7-AS1
 MLK7 antisense RNA 1
 16446
 0.26
chr2_216529775_216530114 0.23 ENSG00000212055
 .
 213698
 0.02
chr3_100279906_100280202 0.23 GPR128
 G protein-coupled receptor 128
 48379
 0.14
chr8_129179760_129180073 0.23 ENSG00000221261
 .
 17554
 0.23
chr7_79783795_79783946 0.23 GNAI1
 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
 18799
 0.26
chr2_46534465_46534616 0.23 EPAS1
 endothelial PAS domain protein 1
 9999
 0.27
chr5_95430378_95430529 0.23 ENSG00000207578
 .
 15611
 0.25
chr5_10366297_10366564 0.23 MARCH6
 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
 12551
 0.14
chr6_71125955_71126106 0.23 RP11-462G2.2
2377
 0.3
chr6_4126077_4126228 0.23 RP3-400B16.4
9505
 0.16
chr12_8845562_8845807 0.23 RIMKLB
 ribosomal modification protein rimK-like family member B
 4089
 0.19
chr2_217342754_217342905 0.23 AC098820.4
9090
 0.16
chr21_27762100_27762398 0.23 AP001596.6
206
 0.95
chr1_85710395_85710781 0.23 C1orf52
 chromosome 1 open reading frame 52
 14728
 0.13
chr6_42192050_42192201 0.23 MRPS10
 mitochondrial ribosomal protein S10
 6522
 0.19
chr12_47353443_47353741 0.23 PCED1B
 PC-esterase domain containing 1B
 119794
 0.06
chr4_138965881_138966032 0.23 ENSG00000250033
 .
 12662
 0.32
chr2_153361073_153361241 0.23 FMNL2
 formin-like 2
 114935
 0.07
chr1_28653212_28653398 0.23 MED18
 mediator complex subunit 18
 2244
 0.26
chr6_15391218_15391573 0.23 JARID2
 jumonji, AT rich interactive domain 2
 9694
 0.25
chr14_103838670_103838952 0.23 MARK3
 MAP/microtubule affinity-regulating kinase 3
 12918
 0.15
chr8_66629441_66629592 0.23 RP11-707M3.3
2503
 0.31
chr7_157145222_157145792 0.23 DNAJB6
 DnaJ (Hsp40) homolog, subfamily B, member 6
 12992
 0.24
chr1_214596757_214596908 0.23 PTPN14
 protein tyrosine phosphatase, non-receptor type 14
 41314
 0.18
chr17_74525558_74526004 0.22 CYGB
 cytoglobin
 2366
 0.14
chr7_41548569_41548720 0.22 INHBA-AS1
 INHBA antisense RNA 1
 184870
 0.03
chr20_44443013_44443361 0.22 UBE2C
 ubiquitin-conjugating enzyme E2C
 1542
 0.2
chr5_142096782_142096998 0.22 FGF1
 fibroblast growth factor 1 (acidic)
 19279
 0.22
chr18_51550193_51550445 0.22 ENSG00000221058
 .
 62707
 0.15
chr7_77495923_77496170 0.22 PHTF2
 putative homeodomain transcription factor 2
 26549
 0.18
chr7_134133604_134133901 0.22 AKR1B1
 aldo-keto reductase family 1, member B1 (aldose reductase)
 10142
 0.26
chr5_149189745_149189896 0.22 PPARGC1B
 peroxisome proliferator-activated receptor gamma, coactivator 1 beta
 22758
 0.18
chr5_53075823_53075974 0.22 ENSG00000263710
 .
 2630
 0.4
chr6_43065272_43065495 0.22 PTK7
 protein tyrosine kinase 7
 20831
 0.09
chr4_55147977_55148291 0.22 PDGFRA
 platelet-derived growth factor receptor, alpha polypeptide
 38392
 0.21
chr2_36603652_36603803 0.22 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 20113
 0.27
chr19_41768990_41769258 0.22 HNRNPUL1
 heterogeneous nuclear ribonucleoprotein U-like 1
 548
 0.66
chr2_48545707_48546468 0.22 FOXN2
 forkhead box N2
 4238
 0.26
chr14_65173299_65173599 0.22 PLEKHG3
 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
 2134
 0.36
chr1_200150874_200151025 0.22 ENSG00000221403
 .
 36987
 0.2
chr15_86016825_86017700 0.22 AKAP13
 A kinase (PRKA) anchor protein 13
 70009
 0.09
chr12_109151621_109151772 0.22 ENSG00000200060
 .
 19436
 0.13
chr2_68464884_68465350 0.22 ENSG00000216115
 .
 8059
 0.14
chr12_63180443_63180611 0.22 ENSG00000200296
 .
 64154
 0.12
chr3_182990531_182990717 0.22 B3GNT5
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
 7492
 0.21
chr1_210407365_210407516 0.22 SERTAD4-AS1
 SERTAD4 antisense RNA 1
 48
 0.97
chr5_52023447_52023598 0.22 ITGA1
 integrin, alpha 1
 60208
 0.12
chr2_40261108_40261259 0.22 SLC8A1-AS1
 SLC8A1 antisense RNA 1
 8307
 0.32
chr6_157719107_157719258 0.22 ENSG00000252609
 .
 6751
 0.25
chr1_44030361_44030512 0.22 PTPRF
 protein tyrosine phosphatase, receptor type, F
 19689
 0.18
chr1_245249339_245249490 0.22 EFCAB2
 EF-hand calcium binding domain 2
 2656
 0.26
chr16_69051284_69051469 0.22 ENSG00000202497
 .
 10318
 0.2
chr18_32230366_32230628 0.21 DTNA
 dystrobrevin, alpha
 29004
 0.24
chr3_119771367_119771672 0.21 GSK3B
 glycogen synthase kinase 3 beta
 40994
 0.16
chr9_80539292_80539443 0.21 GNAQ
 guanine nucleotide binding protein (G protein), q polypeptide
 101452
 0.08
chr17_28060383_28060541 0.21 RP11-82O19.1
27659
 0.13
chr14_78060038_78060870 0.21 SPTLC2
 serine palmitoyltransferase, long chain base subunit 2
 3210
 0.25
chr12_120763372_120763602 0.21 PLA2G1B
 phospholipase A2, group IB (pancreas)
 409
 0.75
chr15_71118836_71119061 0.21 RP11-138H8.6
23161
 0.14
chr12_101382135_101382286 0.21 RP11-350G24.1
50662
 0.14
chr12_94171736_94171888 0.21 RP11-887P2.5
40213
 0.14
chr6_139697731_139697996 0.21 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 2106
 0.42
chr4_140719894_140720045 0.21 ENSG00000252233
 .
 4382
 0.3
chr18_74197341_74197735 0.21 ZNF516
 zinc finger protein 516
 5197
 0.19
chr9_95177326_95177477 0.21 OMD
 osteomodulin
 9342
 0.18
chr3_54925868_54926132 0.21 CACNA2D3-AS1
 CACNA2D3 antisense RNA 1
 9282
 0.27
chr7_106064567_106064855 0.21 CTB-111H14.1
80574
 0.1
chr9_116357080_116357231 0.21 RGS3
 regulator of G-protein signaling 3
 1389
 0.46
chr8_68256392_68257141 0.21 ARFGEF1
 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
 854
 0.75
chr9_110812607_110812758 0.21 ENSG00000222459
 .
 131423
 0.05
chr2_18806956_18807107 0.21 NT5C1B
 5'-nucleotidase, cytosolic IB
 36193
 0.15
chr8_24858429_24858620 0.21 CTD-2168K21.2
44389
 0.16
chr3_113513746_113513897 0.21 GRAMD1C
 GRAM domain containing 1C
 43444
 0.13
chr7_22214667_22214818 0.21 RAPGEF5
 Rap guanine nucleotide exchange factor (GEF) 5
 18785
 0.27
chr2_27942684_27942835 0.21 AC074091.13
 Uncharacterized protein
 4160
 0.18
chr11_129509524_129509675 0.21 TMEM45B
 transmembrane protein 45B
 176115
 0.03
chr4_141019812_141020255 0.21 RP11-392B6.1
29136
 0.21
chr19_45901981_45902244 0.21 PPP1R13L
 protein phosphatase 1, regulatory subunit 13 like
 6184
 0.12
chr1_3112832_3112983 0.21 PRDM16
 PR domain containing 16
 47789
 0.15
chr20_45949788_45949944 0.21 AL031666.2
 HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852
 2620
 0.19
chr5_149422888_149423039 0.21 ENSG00000238369
 .
 13948
 0.14
chr12_93178634_93178785 0.21 EEA1
 early endosome antigen 1
 36166
 0.17
chr20_43970628_43970800 0.21 SDC4
 syndecan 4
 6350
 0.12
chr15_67224295_67224446 0.21 SMAD3
 SMAD family member 3
 131731
 0.05
chr14_69548197_69548348 0.21 ENSG00000206768
 .
 62398
 0.11
chr2_206635568_206635719 0.21 AC007362.3
6913
 0.29

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXO3_FOXD2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 0.2 GO:0022030 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.1 0.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.2 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.1 0.2 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.1 0.2 GO:0022038 corpus callosum development(GO:0022038)
0.1 0.1 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.2 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.2 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.2 GO:0032776 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.2 GO:0006991 response to sterol depletion(GO:0006991)
0.0 0.1 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.2 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.0 0.1 GO:0046881 positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0 0.1 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.1 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.1 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.1 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.1 GO:0009158 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.0 0.2 GO:0045217 cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.3 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0032641 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0 0.1 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0 0.1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0 0.1 GO:0002085 inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0 0.1 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.0 0.0 GO:0060433 bronchus development(GO:0060433)
0.0 0.1 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0033133 regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.0 0.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.0 GO:1903429 regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0 0.1 GO:0001821 histamine secretion(GO:0001821)
0.0 0.1 GO:0046021 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0060676 ureteric bud formation(GO:0060676)
0.0 0.1 GO:0045048 protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.0 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880)
0.0 0.1 GO:1903224 endodermal cell fate commitment(GO:0001711) endodermal cell fate specification(GO:0001714) endodermal cell differentiation(GO:0035987) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.1 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0 0.0 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.0 0.0 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.1 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.1 GO:0003171 atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0 0.1 GO:0032230 positive regulation of synaptic transmission, GABAergic(GO:0032230)
0.0 0.2 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.0 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0 0.2 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.0 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 0.1 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.2 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.2 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.0 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.0 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.2 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.0 GO:0070977 organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0 0.0 GO:0014848 urinary tract smooth muscle contraction(GO:0014848)
0.0 0.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.1 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.1 GO:0032344 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347) regulation of steroid hormone biosynthetic process(GO:0090030)
0.0 0.0 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.1 GO:0030952 establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0 0.1 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.0 GO:0032415 regulation of sodium:proton antiporter activity(GO:0032415) sodium ion transmembrane transport(GO:0035725) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.1 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0009414 response to water deprivation(GO:0009414) response to water(GO:0009415)
0.0 0.1 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.0 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.1 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:0042441 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0 0.2 GO:0060996 dendritic spine development(GO:0060996)
0.0 0.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.0 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664)
0.0 0.1 GO:0007619 courtship behavior(GO:0007619)
0.0 0.0 GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate(GO:0039692) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.0 GO:0071436 sodium ion export(GO:0071436)
0.0 0.1 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0002551 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0010714 positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.0 0.0 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.0 GO:0048752 semicircular canal morphogenesis(GO:0048752) semicircular canal development(GO:0060872)
0.0 0.1 GO:0034405 response to fluid shear stress(GO:0034405)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.0 GO:0003157 endocardium development(GO:0003157) endocardium morphogenesis(GO:0003160) endocardium formation(GO:0060214)
0.0 0.1 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.0 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.0 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.0 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.0 0.1 GO:0051155 positive regulation of striated muscle cell differentiation(GO:0051155)
0.0 0.2 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 0.1 GO:0045916 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.0 GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0 0.1 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.3 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.0 0.2 GO:0006004 fucose metabolic process(GO:0006004)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.0 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.0 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.1 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 0.0 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:0060174 limb bud formation(GO:0060174)
0.0 0.1 GO:0030033 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.1 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.1 GO:0051900 regulation of mitochondrial depolarization(GO:0051900)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.0 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.0 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.0 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.1 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.1 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.2 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 0.0 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.0 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.0 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.0 0.0 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.1 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.0 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.0 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.1 GO:0007143 female meiotic division(GO:0007143)
0.0 0.0 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.0 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.0 GO:0009136 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)
0.0 0.0 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.0 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.0 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.0 GO:0042637 catagen(GO:0042637)
0.0 0.0 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.0 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.0 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 0.1 GO:0060055 angiogenesis involved in wound healing(GO:0060055)
0.0 0.1 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.0 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.1 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 0.0 GO:0009648 photoperiodism(GO:0009648)
0.0 0.0 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.0 GO:0001778 plasma membrane repair(GO:0001778)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0031211 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.2 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0001940 male pronucleus(GO:0001940)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.2 GO:0043205 fibril(GO:0043205)
0.0 0.1 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.0 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.1 GO:0000791 euchromatin(GO:0000791)
0.0 0.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.2 GO:0030530 obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0 0.0 GO:0001739 sex chromatin(GO:0001739)
0.0 0.1 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.2 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.2 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.1 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.2 GO:0032052 bile acid binding(GO:0032052)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.2 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.2 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922)
0.0 0.2 GO:0042171 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.0 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0052834 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.1 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.0 0.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.0 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.2 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0001848 complement binding(GO:0001848)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.0 GO:0004992 platelet activating factor receptor activity(GO:0004992)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.8 GO:0008009 chemokine activity(GO:0008009)
0.0 0.0 GO:0004645 phosphorylase activity(GO:0004645)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.0 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.0 GO:0000987 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.0 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.1 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.0 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.0 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.0 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.2 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.0 GO:0031544 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.0 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.0 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.1 GO:0015923 mannosidase activity(GO:0015923)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.1 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0035240 dopamine binding(GO:0035240)
0.0 0.0 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0 0.2 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.0 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.0 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.0 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.0 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0003709 obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0 0.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.0 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.0 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0043295 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.3 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.1 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.2 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.0 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.2 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.0 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.4 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.6 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 0.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 0.1 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.1 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.0 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.0 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.0 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 0.0 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.0 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.0 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.2 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.1 REACTOME SIGNALLING BY NGF Genes involved in Signalling by NGF