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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for FOXO3_FOXD2

Z-value: 0.73

Motif logo

Transcription factors associated with FOXO3_FOXD2

Gene Symbol	Gene ID	Gene Info
FOXO3 Ensembl NCBI GeneCards UniProt	ENSG00000118689.10	FOXO3
FOXD2 Ensembl NCBI GeneCards UniProt	ENSG00000186564.5	FOXD2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
FOXD2	chr1_47905796_47905947	4182	0.177170	-0.78	1.3e-02	Click!
FOXD2	chr1_47903924_47904075	2310	0.232951	0.62	7.6e-02	Click!
FOXD2	chr1_47902342_47903033	998	0.452227	0.57	1.1e-01	Click!
FOXD2	chr1_47906249_47906400	4635	0.172242	-0.56	1.2e-01	Click!
FOXD2	chr1_47909973_47910124	8359	0.156738	-0.53	1.5e-01	Click!
FOXO3	chr6_108994454_108994605	16980	0.275450	0.89	1.5e-03	Click!
FOXO3	chr6_108885127_108885278	3133	0.374122	-0.88	1.7e-03	Click!
FOXO3	chr6_108949983_108950134	27491	0.245271	-0.83	5.3e-03	Click!
FOXO3	chr6_108948593_108948758	28874	0.240811	-0.81	7.6e-03	Click!
FOXO3	chr6_108917705_108917856	35711	0.217656	0.76	1.7e-02	Click!

Activity of the FOXO3_FOXD2 motif across conditions

Conditions sorted by the z-value of the FOXO3_FOXD2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chrX_9389371_9389522	0.59	TBL1X	transducin (beta)-like 1X-linked	41889	0.22
chr22_24879125_24879276	0.53	ADORA2A-AS1	ADORA2A antisense RNA 1	11563	0.14
chr3_191073989_191074140	0.51	UTS2B	urotensin 2B	25739	0.19
chr14_91488374_91488965	0.40	RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	37809	0.15
chr3_133967811_133967962	0.39	RYK	receptor-like tyrosine kinase	1551	0.52
chr11_10877596_10878299	0.38	ZBED5	zinc finger, BED-type containing 5	1237	0.37
chr19_23437287_23437525	0.37	ZNF724P	zinc finger protein 724, pseudogene	4214	0.29
chr13_33803306_33803457	0.36	STARD13	StAR-related lipid transfer (START) domain containing 13	23238	0.2
chr14_61244389_61244540	0.36	MNAT1	MNAT CDK-activating kinase assembly factor 1	30578	0.19
chr19_34724106_34724375	0.33	KIAA0355	KIAA0355	21202	0.21
chr1_152415265_152415416	0.32	CRNN	cornulin	28601	0.13
chr5_150153974_150154288	0.32	SMIM3	small integral membrane protein 3	3377	0.19
chr1_185066313_185066464	0.32	TRMT1L	tRNA methyltransferase 1 homolog (S. cerevisiae)-like	42304	0.13
chr2_70008722_70008880	0.31	ANXA4	annexin A4	39565	0.14
chr21_39860193_39860344	0.31	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	10077	0.31
chr4_5035629_5036207	0.31	CYTL1	cytokine-like 1	14719	0.22
chr5_52627609_52627883	0.31	FST	follistatin	148493	0.04
chr4_1759756_1760086	0.31	TACC3	transforming, acidic coiled-coil containing protein 3	29790	0.12
chr10_99599816_99599967	0.30	GOLGA7B	golgin A7 family, member B	10105	0.18
chr9_109203596_109203848	0.30	ENSG00000200131	.	238536	0.02
chr14_53821474_53821625	0.29	RP11-547D23.1		201477	0.03
chr6_154614018_154614169	0.29	IPCEF1	interaction protein for cytohesin exchange factors 1	37122	0.22
chr5_37739048_37739199	0.29	ENSG00000206743	.	38584	0.18
chr5_173958937_173959224	0.29	MSX2	msh homeobox 2	192456	0.03
chr6_64516560_64517136	0.29	RP11-59D5__B.2		119	0.98
chr7_100781001_100781597	0.29	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	10920	0.1
chr2_28210866_28211683	0.29	ENSG00000265321	.	7960	0.26
chr3_55525759_55525910	0.28	WNT5A	wingless-type MMTV integration site family, member 5A	1861	0.41
chr6_135989503_135989654	0.28	AHI1	Abelson helper integration site 1	170664	0.03
chr8_94342739_94342890	0.28	LINC00535	long intergenic non-protein coding RNA 535	37900	0.19
chr13_40260042_40260269	0.27	ENSG00000264171	.	21883	0.17
chr8_66629977_66630128	0.27	RP11-707M3.3		3039	0.28
chr4_40157960_40158111	0.27	RP11-395I6.3		10260	0.19
chr11_12147194_12147407	0.27	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	4278	0.32
chr11_116741651_116741802	0.27	SIK3-IT1	SIK3 intronic transcript 1 (non-protein coding)	19711	0.11
chr12_66271805_66272278	0.27	RP11-366L20.2	Uncharacterized protein	3317	0.24
chr12_10794215_10794366	0.27	STYK1	serine/threonine/tyrosine kinase 1	12053	0.16
chr1_8728345_8728654	0.27	RERE	arginine-glutamic acid dipeptide (RE) repeats	12069	0.26
chr3_182980866_182981048	0.27	B3GNT5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	2133	0.32
chr4_74702622_74702974	0.27	CXCL6	chemokine (C-X-C motif) ligand 6	441	0.79
chr6_47236614_47236765	0.27	TNFRSF21	tumor necrosis factor receptor superfamily, member 21	40952	0.2
chr3_45576267_45576542	0.27	LARS2-AS1	LARS2 antisense RNA 1	25367	0.18
chr20_22990587_22990738	0.27	RP4-753D10.5		20760	0.15
chr15_68376694_68376845	0.27	PIAS1	protein inhibitor of activated STAT, 1	29855	0.22
chr19_18575570_18575881	0.26	ELL	elongation factor RNA polymerase II	11018	0.1
chr19_39187756_39187907	0.26	CTB-186G2.4		3585	0.14
chr1_31870789_31870940	0.26	SERINC2	serine incorporator 2	11548	0.15
chr19_38423275_38423557	0.26	SIPA1L3	signal-induced proliferation-associated 1 like 3	25548	0.15
chr3_58320540_58320691	0.26	PXK	PX domain containing serine/threonine kinase	1582	0.4
chr1_33853388_33853681	0.26	PHC2	polyhomeotic homolog 2 (Drosophila)	12340	0.15
chr6_35568601_35569436	0.26	ENSG00000212579	.	50577	0.1
chr10_3134024_3134295	0.26	PFKP	phosphofructokinase, platelet	12757	0.24
chr16_17566923_17567074	0.26	XYLT1	xylosyltransferase I	2260	0.48
chr2_217051631_217052157	0.26	AC012513.6		72424	0.09
chr12_6198255_6198797	0.26	ENSG00000240533	.	6610	0.23
chr12_113684408_113684559	0.26	TPCN1	two pore segment channel 1	2310	0.23
chr13_80443621_80443990	0.26	NDFIP2	Nedd4 family interacting protein 2	388217	0.01
chr5_75969089_75969240	0.26	F2R	coagulation factor II (thrombin) receptor	42704	0.11
chr1_185703151_185703455	0.25	HMCN1	hemicentin 1	380	0.92
chr1_234755566_234755985	0.25	IRF2BP2	interferon regulatory factor 2 binding protein 2	10504	0.19
chr15_96898066_96898266	0.25	AC087477.1	Uncharacterized protein	6321	0.18
chr12_124992848_124993269	0.25	NCOR2	nuclear receptor corepressor 2	9782	0.31
chr5_171382567_171382718	0.25	FBXW11	F-box and WD repeat domain containing 11	22118	0.23
chr1_59034555_59034706	0.25	ENSG00000264128	.	3026	0.26
chr6_49293968_49294177	0.25	ENSG00000252457	.	18449	0.26
chr16_4103086_4103844	0.25	RP11-462G12.4		21452	0.2
chr12_78579294_78579445	0.25	NAV3	neuron navigator 3	13487	0.3
chr1_201463290_201463773	0.25	CSRP1	cysteine and glycine-rich protein 1	2170	0.26
chr19_18491035_18491248	0.25	GDF15	growth differentiation factor 15	1839	0.18
chr5_124895396_124895838	0.25	ENSG00000222107	.	208793	0.03
chr16_83859962_83860113	0.25	HSBP1	heat shock factor binding protein 1	18443	0.15
chr2_192530317_192530468	0.25	NABP1	nucleic acid binding protein 1	12470	0.29
chr9_118403979_118404130	0.25	DEC1	deleted in esophageal cancer 1	499957	0.0
chr2_159955686_159955837	0.25	ENSG00000202029	.	72107	0.11
chr9_108873656_108873902	0.25	TMEM38B	transmembrane protein 38B	389811	0.01
chr5_123646330_123646481	0.25	RP11-436H11.2		418119	0.01
chr12_89764903_89765288	0.25	DUSP6	dual specificity phosphatase 6	18047	0.24
chr20_1796404_1796650	0.24	SIRPA	signal-regulatory protein alpha	78627	0.09
chr11_10828028_10828469	0.24	EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	761	0.52
chr5_169577969_169578120	0.24	FOXI1	forkhead box I1	45127	0.16
chr16_56404978_56405129	0.24	RP11-441F2.5		17617	0.13
chr3_197043921_197044177	0.24	DLG1	discs, large homolog 1 (Drosophila)	17878	0.15
chr6_33930401_33930552	0.24	ENSG00000221697	.	37352	0.18
chr7_17246525_17246676	0.24	AC003075.4		74327	0.11
chr6_56514356_56514539	0.24	DST	dystonin	6653	0.32
chr18_43325991_43326142	0.24	RP11-116O18.3		1114	0.51
chr4_74863945_74864096	0.24	CXCL5	chemokine (C-X-C motif) ligand 5	476	0.73
chr1_65643796_65643947	0.24	AK4	adenylate kinase 4	29985	0.19
chr3_46607636_46607787	0.24	LRRC2	leucine rich repeat containing 2	329	0.83
chr4_157242892_157243172	0.24	ENSG00000221189	.	25234	0.27
chr7_41046808_41047238	0.24	AC005160.3		231866	0.02
chr22_45106414_45106589	0.24	ARHGAP8	Rho GTPase activating protein 8	8119	0.19
chr3_130693410_130693561	0.24	ATP2C1	ATPase, Ca++ transporting, type 2C, member 1	7253	0.18
chr8_128919633_128920053	0.24	TMEM75	transmembrane protein 75	40748	0.15
chr7_86783673_86784219	0.24	DMTF1	cyclin D binding myb-like transcription factor 1	1999	0.29
chr2_216658765_216659109	0.24	ENSG00000212055	.	84705	0.1
chr9_107687183_107687334	0.24	RP11-217B7.2		2576	0.3
chr3_87309504_87309716	0.24	POU1F1	POU class 1 homeobox 1	16002	0.21
chr4_157860965_157861230	0.24	PDGFC	platelet derived growth factor C	30958	0.19
chr1_77980530_77980774	0.24	AK5	adenylate kinase 5	17140	0.22
chr22_30023302_30023509	0.24	NF2	neurofibromin 2 (merlin)	23417	0.14
chr17_45005909_45006060	0.24	GOSR2	golgi SNAP receptor complex member 2	5421	0.17
chr17_60004372_60004770	0.24	INTS2	integrator complex subunit 2	216	0.94
chr1_9498520_9498686	0.24	ENSG00000252956	.	766	0.72
chr12_104274321_104274475	0.24	RP11-650K20.3	Uncharacterized protein	39169	0.1
chr8_134353152_134353303	0.24	NDRG1	N-myc downstream regulated 1	38962	0.2
chr2_45822706_45822857	0.23	SRBD1	S1 RNA binding domain 1	15639	0.21
chr1_168051282_168051433	0.23	GPR161	G protein-coupled receptor 161	22810	0.21
chr17_66449042_66449331	0.23	WIPI1	WD repeat domain, phosphoinositide interacting 1	4376	0.23
chr10_60347392_60347543	0.23	BICC1	bicaudal C homolog 1 (Drosophila)	74567	0.12
chr7_17081811_17082046	0.23	AGR3	anterior gradient 3	160317	0.04
chr6_170535437_170535588	0.23	RP5-1086L22.1		36145	0.15
chr17_26673764_26673915	0.23	TNFAIP1	tumor necrosis factor, alpha-induced protein 1 (endothelial)	6407	0.07
chrX_9755049_9755347	0.23	SHROOM2	shroom family member 2	702	0.51
chr2_174055819_174055970	0.23	MLK7-AS1	MLK7 antisense RNA 1	16446	0.26
chr2_216529775_216530114	0.23	ENSG00000212055	.	213698	0.02
chr3_100279906_100280202	0.23	GPR128	G protein-coupled receptor 128	48379	0.14
chr8_129179760_129180073	0.23	ENSG00000221261	.	17554	0.23
chr7_79783795_79783946	0.23	GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	18799	0.26
chr2_46534465_46534616	0.23	EPAS1	endothelial PAS domain protein 1	9999	0.27
chr5_95430378_95430529	0.23	ENSG00000207578	.	15611	0.25
chr5_10366297_10366564	0.23	MARCH6	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase	12551	0.14
chr6_71125955_71126106	0.23	RP11-462G2.2		2377	0.3
chr6_4126077_4126228	0.23	RP3-400B16.4		9505	0.16
chr12_8845562_8845807	0.23	RIMKLB	ribosomal modification protein rimK-like family member B	4089	0.19
chr2_217342754_217342905	0.23	AC098820.4		9090	0.16
chr21_27762100_27762398	0.23	AP001596.6		206	0.95
chr1_85710395_85710781	0.23	C1orf52	chromosome 1 open reading frame 52	14728	0.13
chr6_42192050_42192201	0.23	MRPS10	mitochondrial ribosomal protein S10	6522	0.19
chr12_47353443_47353741	0.23	PCED1B	PC-esterase domain containing 1B	119794	0.06
chr4_138965881_138966032	0.23	ENSG00000250033	.	12662	0.32
chr2_153361073_153361241	0.23	FMNL2	formin-like 2	114935	0.07
chr1_28653212_28653398	0.23	MED18	mediator complex subunit 18	2244	0.26
chr6_15391218_15391573	0.23	JARID2	jumonji, AT rich interactive domain 2	9694	0.25
chr14_103838670_103838952	0.23	MARK3	MAP/microtubule affinity-regulating kinase 3	12918	0.15
chr8_66629441_66629592	0.23	RP11-707M3.3		2503	0.31
chr7_157145222_157145792	0.23	DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	12992	0.24
chr1_214596757_214596908	0.23	PTPN14	protein tyrosine phosphatase, non-receptor type 14	41314	0.18
chr17_74525558_74526004	0.22	CYGB	cytoglobin	2366	0.14
chr7_41548569_41548720	0.22	INHBA-AS1	INHBA antisense RNA 1	184870	0.03
chr20_44443013_44443361	0.22	UBE2C	ubiquitin-conjugating enzyme E2C	1542	0.2
chr5_142096782_142096998	0.22	FGF1	fibroblast growth factor 1 (acidic)	19279	0.22
chr18_51550193_51550445	0.22	ENSG00000221058	.	62707	0.15
chr7_77495923_77496170	0.22	PHTF2	putative homeodomain transcription factor 2	26549	0.18
chr7_134133604_134133901	0.22	AKR1B1	aldo-keto reductase family 1, member B1 (aldose reductase)	10142	0.26
chr5_149189745_149189896	0.22	PPARGC1B	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	22758	0.18
chr5_53075823_53075974	0.22	ENSG00000263710	.	2630	0.4
chr6_43065272_43065495	0.22	PTK7	protein tyrosine kinase 7	20831	0.09
chr4_55147977_55148291	0.22	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	38392	0.21
chr2_36603652_36603803	0.22	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	20113	0.27
chr19_41768990_41769258	0.22	HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	548	0.66
chr2_48545707_48546468	0.22	FOXN2	forkhead box N2	4238	0.26
chr14_65173299_65173599	0.22	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	2134	0.36
chr1_200150874_200151025	0.22	ENSG00000221403	.	36987	0.2
chr15_86016825_86017700	0.22	AKAP13	A kinase (PRKA) anchor protein 13	70009	0.09
chr12_109151621_109151772	0.22	ENSG00000200060	.	19436	0.13
chr2_68464884_68465350	0.22	ENSG00000216115	.	8059	0.14
chr12_63180443_63180611	0.22	ENSG00000200296	.	64154	0.12
chr3_182990531_182990717	0.22	B3GNT5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	7492	0.21
chr1_210407365_210407516	0.22	SERTAD4-AS1	SERTAD4 antisense RNA 1	48	0.97
chr5_52023447_52023598	0.22	ITGA1	integrin, alpha 1	60208	0.12
chr2_40261108_40261259	0.22	SLC8A1-AS1	SLC8A1 antisense RNA 1	8307	0.32
chr6_157719107_157719258	0.22	ENSG00000252609	.	6751	0.25
chr1_44030361_44030512	0.22	PTPRF	protein tyrosine phosphatase, receptor type, F	19689	0.18
chr1_245249339_245249490	0.22	EFCAB2	EF-hand calcium binding domain 2	2656	0.26
chr16_69051284_69051469	0.22	ENSG00000202497	.	10318	0.2
chr18_32230366_32230628	0.21	DTNA	dystrobrevin, alpha	29004	0.24
chr3_119771367_119771672	0.21	GSK3B	glycogen synthase kinase 3 beta	40994	0.16
chr9_80539292_80539443	0.21	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	101452	0.08
chr17_28060383_28060541	0.21	RP11-82O19.1		27659	0.13
chr14_78060038_78060870	0.21	SPTLC2	serine palmitoyltransferase, long chain base subunit 2	3210	0.25
chr12_120763372_120763602	0.21	PLA2G1B	phospholipase A2, group IB (pancreas)	409	0.75
chr15_71118836_71119061	0.21	RP11-138H8.6		23161	0.14
chr12_101382135_101382286	0.21	RP11-350G24.1		50662	0.14
chr12_94171736_94171888	0.21	RP11-887P2.5		40213	0.14
chr6_139697731_139697996	0.21	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	2106	0.42
chr4_140719894_140720045	0.21	ENSG00000252233	.	4382	0.3
chr18_74197341_74197735	0.21	ZNF516	zinc finger protein 516	5197	0.19
chr9_95177326_95177477	0.21	OMD	osteomodulin	9342	0.18
chr3_54925868_54926132	0.21	CACNA2D3-AS1	CACNA2D3 antisense RNA 1	9282	0.27
chr7_106064567_106064855	0.21	CTB-111H14.1		80574	0.1
chr9_116357080_116357231	0.21	RGS3	regulator of G-protein signaling 3	1389	0.46
chr8_68256392_68257141	0.21	ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	854	0.75
chr9_110812607_110812758	0.21	ENSG00000222459	.	131423	0.05
chr2_18806956_18807107	0.21	NT5C1B	5'-nucleotidase, cytosolic IB	36193	0.15
chr8_24858429_24858620	0.21	CTD-2168K21.2		44389	0.16
chr3_113513746_113513897	0.21	GRAMD1C	GRAM domain containing 1C	43444	0.13
chr7_22214667_22214818	0.21	RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5	18785	0.27
chr2_27942684_27942835	0.21	AC074091.13	Uncharacterized protein	4160	0.18
chr11_129509524_129509675	0.21	TMEM45B	transmembrane protein 45B	176115	0.03
chr4_141019812_141020255	0.21	RP11-392B6.1		29136	0.21
chr19_45901981_45902244	0.21	PPP1R13L	protein phosphatase 1, regulatory subunit 13 like	6184	0.12
chr1_3112832_3112983	0.21	PRDM16	PR domain containing 16	47789	0.15
chr20_45949788_45949944	0.21	AL031666.2	HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852	2620	0.19
chr5_149422888_149423039	0.21	ENSG00000238369	.	13948	0.14
chr12_93178634_93178785	0.21	EEA1	early endosome antigen 1	36166	0.17
chr20_43970628_43970800	0.21	SDC4	syndecan 4	6350	0.12
chr15_67224295_67224446	0.21	SMAD3	SMAD family member 3	131731	0.05
chr14_69548197_69548348	0.21	ENSG00000206768	.	62398	0.11
chr2_206635568_206635719	0.21	AC007362.3		6913	0.29

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXO3_FOXD2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.1	0.2	GO:0022030	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.1	0.2	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.1	0.2	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.1	0.2	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.1	0.2	GO:0022038	corpus callosum development(GO:0022038)
0.1	0.1	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.2	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.2	GO:0008218	bioluminescence(GO:0008218)
0.0	0.2	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.2	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.2	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.2	GO:0006991	response to sterol depletion(GO:0006991)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.2	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.2	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.2	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.0	0.1	GO:0046881	positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.1	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.1	GO:0009158	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.2	GO:0045217	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.1	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.3	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0032641	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.1	GO:0042984	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.1	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.1	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.0	GO:0060433	bronchus development(GO:0060433)
0.0	0.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.1	GO:0033133	regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.0	GO:1903429	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0046021	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.1	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.0	GO:0046880	regulation of follicle-stimulating hormone secretion(GO:0046880)
0.0	0.1	GO:1903224	endodermal cell fate commitment(GO:0001711) endodermal cell fate specification(GO:0001714) endodermal cell differentiation(GO:0035987) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.1	GO:0046855	phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0	0.0	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.0	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.1	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.1	GO:0003171	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.1	GO:0032230	positive regulation of synaptic transmission, GABAergic(GO:0032230)
0.0	0.2	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.0	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.2	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.0	GO:0051877	pigment granule aggregation in cell center(GO:0051877)
0.0	0.1	GO:0042797	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.1	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.2	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.2	GO:0034453	microtubule anchoring(GO:0034453)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.0	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.0	GO:0048368	lateral mesoderm development(GO:0048368)
0.0	0.2	GO:0016180	snRNA processing(GO:0016180)
0.0	0.1	GO:0048853	forebrain morphogenesis(GO:0048853)
0.0	0.0	GO:0070977	organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0	0.0	GO:0014848	urinary tract smooth muscle contraction(GO:0014848)
0.0	0.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.1	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.1	GO:0032344	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347) regulation of steroid hormone biosynthetic process(GO:0090030)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0030952	establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0	0.1	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.0	GO:0032415	regulation of sodium:proton antiporter activity(GO:0032415) sodium ion transmembrane transport(GO:0035725) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414) response to water(GO:0009415)
0.0	0.1	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.1	GO:0042441	eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0	0.2	GO:0060996	dendritic spine development(GO:0060996)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.0	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664)
0.0	0.1	GO:0007619	courtship behavior(GO:0007619)
0.0	0.0	GO:0039692	single stranded viral RNA replication via double stranded DNA intermediate(GO:0039692) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0002551	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0010714	positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.0	0.0	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.0	GO:0048752	semicircular canal morphogenesis(GO:0048752) semicircular canal development(GO:0060872)
0.0	0.1	GO:0034405	response to fluid shear stress(GO:0034405)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.0	GO:0003157	endocardium development(GO:0003157) endocardium morphogenesis(GO:0003160) endocardium formation(GO:0060214)
0.0	0.1	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.0	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.0	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.1	GO:0051155	positive regulation of striated muscle cell differentiation(GO:0051155)
0.0	0.2	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.1	GO:0045916	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.1	GO:0006910	phagocytosis, recognition(GO:0006910)
0.0	0.3	GO:0048146	positive regulation of fibroblast proliferation(GO:0048146)
0.0	0.2	GO:0006004	fucose metabolic process(GO:0006004)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.0	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.0	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.1	GO:0060716	labyrinthine layer blood vessel development(GO:0060716)
0.0	0.0	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0060174	limb bud formation(GO:0060174)
0.0	0.1	GO:0030033	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.1	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.1	GO:0051900	regulation of mitochondrial depolarization(GO:0051900)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.0	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.0	0.0	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.2	GO:0045103	intermediate filament-based process(GO:0045103)
0.0	0.0	GO:0006452	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.0	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.0	GO:0016199	axon midline choice point recognition(GO:0016199)
0.0	0.1	GO:0006378	mRNA polyadenylation(GO:0006378)
0.0	0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.0	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0007143	female meiotic division(GO:0007143)
0.0	0.0	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.0	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.0	GO:0009136	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.1	GO:0015074	DNA integration(GO:0015074)
0.0	0.0	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.0	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:0042637	catagen(GO:0042637)
0.0	0.0	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.0	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.0	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.1	GO:0060055	angiogenesis involved in wound healing(GO:0060055)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.0	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0051096	positive regulation of helicase activity(GO:0051096)
0.0	0.0	GO:0009648	photoperiodism(GO:0009648)
0.0	0.0	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0031211	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.2	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.2	GO:0030673	axolemma(GO:0030673)
0.0	0.2	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.2	GO:0032039	integrator complex(GO:0032039)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0031332	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.2	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.1	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.2	GO:0043205	fibril(GO:0043205)
0.0	0.1	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.2	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.1	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.2	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.0	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0	0.1	GO:0031941	filamentous actin(GO:0031941)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0033162	melanosome membrane(GO:0033162) chitosome(GO:0045009)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1	0.2	GO:0031127	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.2	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.2	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.2	GO:0032052	bile acid binding(GO:0032052)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.2	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0034711	inhibin binding(GO:0034711)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.2	GO:0005112	Notch binding(GO:0005112)
0.0	0.2	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.2	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.2	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.1	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.0	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.1	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0	0.2	GO:0042301	phosphate ion binding(GO:0042301)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0001848	complement binding(GO:0001848)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.0	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.8	GO:0008009	chemokine activity(GO:0008009)
0.0	0.0	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.0	GO:0004052	arachidonate 12-lipoxygenase activity(GO:0004052)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.0	GO:0000987	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0	0.0	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.1	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.0	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.2	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.2	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.0	GO:0031544	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.2	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.0	GO:0030343	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.1	GO:0015923	mannosidase activity(GO:0015923)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0035240	dopamine binding(GO:0035240)
0.0	0.0	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.2	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.2	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.0	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.0	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.0	GO:0008187	poly-pyrimidine tract binding(GO:0008187)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.0	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.0	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.0	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.1	GO:0031369	translation initiation factor binding(GO:0031369)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0043295	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.1	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.3	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	0.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	0.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.1	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	0.2	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.0	0.0	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	0.2	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	0.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.0	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.4	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.0	0.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.6	PID NOTCH PATHWAY	Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1	0.1	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1	0.1	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.1	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.0	0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.0	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.0	0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.1	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	0.2	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	0.0	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.0	0.0	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.2	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.1	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.2	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.2	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.0	0.0	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.2	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.1	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.0	0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.2	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.1	REACTOME SIGNALLING BY NGF	Genes involved in Signalling by NGF