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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for GZF1

Z-value: 0.99

Motif logo

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Transcription factors associated with GZF1

Gene Symbol Gene ID Gene Info
GZF1
ENSG00000125812.11 GZF1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
GZF1chr20_23346727_2334694618150.2123920.854.0e-03Click!
GZF1chr20_23346451_2334660215050.2532650.752.0e-02Click!
GZF1chr20_23348740_2334889137940.130752-0.636.7e-02Click!
GZF1chr20_23346043_2334619410970.3476830.609.0e-02Click!
GZF1chr20_23346955_2334710620090.1944710.541.3e-01Click!

Activity of the GZF1 motif across conditions

Conditions sorted by the z-value of the GZF1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr7_140058363_140058567 0.41 SLC37A3
 solute carrier family 37, member 3
 6565
 0.15
chr11_67049148_67049384 0.37 ANKRD13D
 ankyrin repeat domain 13 family, member D
 6752
 0.12
chr14_59950418_59950569 0.35 L3HYPDH
 L-3-hydroxyproline dehydratase (trans-)
 90
 0.91
chr12_129278613_129278971 0.35 SLC15A4
 solute carrier family 15 (oligopeptide transporter), member 4
 7454
 0.27
chr5_157286748_157286966 0.35 CLINT1
 clathrin interactor 1
 674
 0.75
chrX_153534844_153535009 0.34 TKTL1
 transketolase-like 1
 1517
 0.24
chr21_15855177_15855351 0.33 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 63398
 0.12
chr14_36789095_36789307 0.32 MBIP
 MAP3K12 binding inhibitory protein 1
 125
 0.97
chr6_35838535_35838686 0.32 SRPK1
 SRSF protein kinase 1
 50214
 0.11
chr2_198119149_198119485 0.32 ANKRD44-IT1
 ANKRD44 intronic transcript 1 (non-protein coding)
 47926
 0.12
chr1_168504102_168504301 0.30 XCL2
 chemokine (C motif) ligand 2
 9034
 0.25
chrX_65081944_65082241 0.30 RP6-159A1.3
137501
 0.05
chr19_54928713_54928864 0.30 TTYH1
 tweety family member 1
 2088
 0.17
chr20_34077500_34077678 0.30 RP3-477O4.14
1154
 0.34
chr20_48417718_48417888 0.30 ENSG00000252540
 .
 6455
 0.17
chr7_38256301_38256485 0.29 STARD3NL
 STARD3 N-terminal like
 38396
 0.22
chr2_187351499_187351878 0.29 ZC3H15
 zinc finger CCCH-type containing 15
 708
 0.69
chr8_126718847_126719004 0.29 ENSG00000206695
 .
 194270
 0.03
chr2_62427282_62427433 0.29 B3GNT2
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
 4109
 0.2
chr10_73499941_73500092 0.29 C10orf105
 chromosome 10 open reading frame 105
 2435
 0.3
chr16_50309553_50309704 0.29 ADCY7
 adenylate cyclase 7
 1564
 0.41
chr17_68285276_68285427 0.29 KCNJ2
 potassium inwardly-rectifying channel, subfamily J, member 2
 119675
 0.06
chr9_132651876_132652490 0.29 FNBP1
 formin binding protein 1
 29406
 0.13
chr2_113940950_113941232 0.29 AC016683.5
8154
 0.14
chr10_30863847_30863998 0.28 ENSG00000239744
 .
 19089
 0.22
chr16_22218333_22218484 0.28 EEF2K
 eukaryotic elongation factor-2 kinase
 805
 0.63
chr11_111957057_111957216 0.28 SDHD
 succinate dehydrogenase complex, subunit D, integral membrane protein
 361
 0.46
chr10_118652800_118653001 0.28 ENO4
 enolase family member 4
 34355
 0.17
chr11_118055454_118055605 0.28 SCN2B
 sodium channel, voltage-gated, type II, beta subunit
 8141
 0.15
chr22_40322306_40322457 0.27 GRAP2
 GRB2-related adaptor protein 2
 214
 0.93
chr4_109103898_109104112 0.27 ENSG00000232021
 .
 6561
 0.25
chr10_104005871_104006203 0.27 GBF1
 golgi brefeldin A resistant guanine nucleotide exchange factor 1
 748
 0.56
chr2_2000070_2000423 0.27 MYT1L
 myelin transcription factor 1-like
 153588
 0.04
chr1_77748105_77748256 0.26 AK5
 adenylate kinase 5
 107
 0.98
chr14_107130545_107130696 0.26 IGHV3-66
 immunoglobulin heavy variable 3-66
 940
 0.18
chr20_419998_420268 0.26 ENSG00000206797
 .
 11174
 0.15
chr14_50557550_50557701 0.25 C14orf183
 chromosome 14 open reading frame 183
 1736
 0.29
chr1_239550914_239551159 0.25 CHRM3
 cholinergic receptor, muscarinic 3
 241337
 0.02
chr6_15315532_15315775 0.25 ENSG00000201367
 .
 502
 0.81
chr1_230296504_230296655 0.24 GALNT2
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
 93561
 0.08
chr5_130405277_130405629 0.24 HINT1
 histidine triad nucleotide binding protein 1
 92867
 0.09
chr2_46665870_46666021 0.24 ENSG00000241791
 .
 9705
 0.2
chr3_87040067_87040263 0.24 VGLL3
 vestigial like 3 (Drosophila)
 92
 0.99
chr5_118668072_118668246 0.24 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 711
 0.71
chr7_102938360_102938511 0.24 PMPCB
 peptidase (mitochondrial processing) beta
 532
 0.76
chr1_38315162_38315404 0.24 MTF1
 metal-regulatory transcription factor 1
 10009
 0.1
chr11_749652_749928 0.24 TALDO1
 transaldolase 1
 2362
 0.12
chr6_11374826_11375046 0.24 NEDD9
 neural precursor cell expressed, developmentally down-regulated 9
 7596
 0.29
chr1_145928317_145928496 0.24 PDZK1P1
 PDZ domain containing 1 pseudogene 1
 11707
 0.16
chr1_160577265_160577416 0.24 CD84
 CD84 molecule
 28034
 0.12
chrX_142720411_142720668 0.24 SLITRK4
 SLIT and NTRK-like family, member 4
 1780
 0.48
chr20_25370250_25370403 0.24 ABHD12
 abhydrolase domain containing 12
 444
 0.85
chr17_3816161_3816362 0.23 P2RX1
 purinergic receptor P2X, ligand-gated ion channel, 1
 3533
 0.2
chr22_32560080_32560278 0.23 C22orf42
 chromosome 22 open reading frame 42
 4904
 0.17
chr17_2696074_2696428 0.23 RAP1GAP2
 RAP1 GTPase activating protein 2
 3481
 0.22
chr1_110047130_110047281 0.23 AMIGO1
 adhesion molecule with Ig-like domain 1
 5099
 0.11
chr11_95094119_95094342 0.23 ENSG00000201204
 .
 112308
 0.06
chr7_6422686_6422957 0.23 RAC1
 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
 8651
 0.18
chr15_64720549_64720703 0.23 TRIP4
 thyroid hormone receptor interactor 4
 4312
 0.13
chrX_75392533_75392684 0.23 PBDC1
 polysaccharide biosynthesis domain containing 1
 163
 0.97
chr14_101292334_101292485 0.23 AL117190.2
3128
 0.07
chr10_14615009_14615187 0.23 FAM107B
 family with sequence similarity 107, member B
 760
 0.73
chr1_54843922_54844304 0.22 SSBP3
 single stranded DNA binding protein 3
 27064
 0.19
chr8_99956309_99956579 0.22 OSR2
 odd-skipped related transciption factor 2
 226
 0.9
chrX_19868073_19868317 0.22 SH3KBP1
 SH3-domain kinase binding protein 1
 37382
 0.2
chr9_134879882_134880105 0.22 MED27
 mediator complex subunit 27
 75260
 0.11
chr3_112059886_112060037 0.22 CD200
 CD200 molecule
 7936
 0.25
chr6_1850485_1850731 0.22 FOXC1
 forkhead box C1
 239927
 0.02
chr9_7977771_7977988 0.22 TMEM261
 transmembrane protein 261
 177812
 0.04
chr12_32115294_32115445 0.21 KIAA1551
 KIAA1551
 54
 0.98
chr11_2812322_2812544 0.21 KCNQ1-AS1
 KCNQ1 antisense RNA 1
 70365
 0.08
chr9_131133838_131134081 0.21 URM1
 ubiquitin related modifier 1
 309
 0.81
chr1_205583719_205584005 0.21 ELK4
 ELK4, ETS-domain protein (SRF accessory protein 1)
 17228
 0.14
chr17_56407049_56407274 0.21 BZRAP1-AS1
 BZRAP1 antisense RNA 1
 195
 0.84
chr12_116986256_116986469 0.21 MAP1LC3B2
 microtubule-associated protein 1 light chain 3 beta 2
 10824
 0.28
chr21_15916640_15916923 0.21 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 1881
 0.42
chr3_32344273_32344503 0.21 ENSG00000207857
 .
 43168
 0.14
chr3_179675139_179675303 0.21 PEX5L
 peroxisomal biogenesis factor 5-like
 15819
 0.24
chr9_74390054_74390240 0.21 TMEM2
 transmembrane protein 2
 6347
 0.31
chr20_24271413_24271883 0.20 ENSG00000200231
 .
 53757
 0.17
chr1_110611840_110612052 0.20 ALX3
 ALX homeobox 3
 1376
 0.31
chr16_17478039_17478236 0.20 XYLT1
 xylosyltransferase I
 86601
 0.11
chr17_78247850_78248001 0.20 RNF213
 ring finger protein 213
 13256
 0.15
chr20_48439855_48440008 0.20 ENSG00000252123
 .
 4598
 0.18
chr1_147470017_147470168 0.20 ENSG00000206791
 .
 16723
 0.19
chr6_106545393_106545544 0.20 PRDM1
 PR domain containing 1, with ZNF domain
 1013
 0.56
chr14_50319739_50319890 0.20 NEMF
 nuclear export mediator factor
 107
 0.89
chr9_97090440_97090723 0.20 NUTM2F
 NUT family member 2F
 345
 0.89
chr11_110708426_110708577 0.20 ARHGAP20
 Rho GTPase activating protein 20
 124589
 0.06
chr8_6566732_6567036 0.20 AGPAT5
 1-acylglycerol-3-phosphate O-acyltransferase 5
 670
 0.58
chr9_138881295_138881528 0.20 UBAC1
 UBA domain containing 1
 28185
 0.17
chr11_36423240_36423525 0.20 PRR5L
 proline rich 5 like
 767
 0.66
chr9_95877175_95877370 0.20 C9orf89
 chromosome 9 open reading frame 89
 18772
 0.14
chr11_72322937_72323189 0.20 ENSG00000272036
 .
 3111
 0.17
chr22_46684505_46684828 0.20 GTSE1
 G-2 and S-phase expressed 1
 7972
 0.15
chr2_8517146_8517394 0.20 AC011747.7
298626
 0.01
chr2_2000524_2000698 0.20 MYT1L
 myelin transcription factor 1-like
 153953
 0.04
chr2_134913656_134913807 0.20 ENSG00000263813
 .
 29035
 0.2
chr9_99691569_99691774 0.20 NUTM2G
 NUT family member 2G
 385
 0.89
chr8_21916870_21917081 0.20 DMTN
 dematin actin binding protein
 241
 0.88
chr3_45018010_45018161 0.20 EXOSC7
 exosome component 7
 363
 0.51
chr2_203776193_203776517 0.19 CARF
 calcium responsive transcription factor
 582
 0.45
chr7_129714164_129714315 0.19 KLHDC10
 kelch domain containing 10
 3627
 0.19
chr3_5233671_5233989 0.19 EDEM1
 ER degradation enhancer, mannosidase alpha-like 1
 3796
 0.18
chrX_19758311_19758804 0.19 SH3KBP1
 SH3-domain kinase binding protein 1
 398
 0.92
chr3_171197799_171197950 0.19 TNIK
 TRAF2 and NCK interacting kinase
 19677
 0.19
chr20_1473982_1474133 0.19 SIRPB2
 signal-regulatory protein beta 2
 1930
 0.25
chr2_232165655_232165809 0.19 ARMC9
 armadillo repeat containing 9
 30487
 0.16
chr2_143908158_143909031 0.19 RP11-190J23.1
21147
 0.22
chr22_37319301_37319452 0.19 CSF2RB
 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
 423
 0.77
chr2_86080450_86080721 0.19 ST3GAL5
 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
 14192
 0.17
chr6_35558805_35559048 0.19 ENSG00000212579
 .
 60669
 0.09
chr2_143883334_143883719 0.19 ARHGAP15
 Rho GTPase activating protein 15
 3357
 0.33
chr7_99965278_99965466 0.18 PILRA
 paired immunoglobin-like type 2 receptor alpha
 219
 0.85
chr21_36411020_36411357 0.18 RUNX1
 runt-related transcription factor 1
 10274
 0.32
chr4_129835794_129835945 0.18 JADE1
 jade family PHD finger 1
 83281
 0.11
chr9_77728037_77728188 0.18 OSTF1
 osteoclast stimulating factor 1
 24653
 0.16
chr8_11558200_11558351 0.18 GATA4
 GATA binding protein 4
 3385
 0.25
chr15_41688710_41688871 0.18 NDUFAF1
 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1
 5850
 0.16
chr11_2502582_2502749 0.18 KCNQ1
 potassium voltage-gated channel, KQT-like subfamily, member 1
 19548
 0.16
chr6_159074020_159074298 0.18 SYTL3
 synaptotagmin-like 3
 3113
 0.24
chr1_212463226_212463384 0.18 PPP2R5A
 protein phosphatase 2, regulatory subunit B', alpha
 4426
 0.19
chr17_25808384_25808701 0.18 KSR1
 kinase suppressor of ras 1
 9506
 0.2
chr2_40712943_40713094 0.18 SLC8A1
 solute carrier family 8 (sodium/calcium exchanger), member 1
 26483
 0.27
chr17_4391049_4391200 0.18 RP13-580F15.2
1476
 0.3
chr2_201827346_201827560 0.18 ORC2
 origin recognition complex, subunit 2
 528
 0.42
chr15_29247145_29247302 0.18 APBA2
 amyloid beta (A4) precursor protein-binding, family A, member 2
 6284
 0.25
chr6_112311435_112311966 0.18 WISP3
 WNT1 inducible signaling pathway protein 3
 63575
 0.11
chr6_13434535_13434686 0.18 GFOD1
 glucose-fructose oxidoreductase domain containing 1
 26241
 0.16
chr14_65165014_65165274 0.18 PLEKHG3
 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
 5676
 0.24
chr19_10449056_10449486 0.18 ICAM3
 intercellular adhesion molecule 3
 1024
 0.31
chr2_2000849_2001005 0.17 MYT1L
 myelin transcription factor 1-like
 154269
 0.04
chr11_121366062_121366254 0.17 RP11-730K11.1
42436
 0.18
chr11_121205690_121205841 0.17 SC5D
 sterol-C5-desaturase
 42204
 0.19
chr14_25457947_25458098 0.17 STXBP6
 syntaxin binding protein 6 (amisyn)
 21824
 0.27
chr18_61642862_61643013 0.17 SERPINB8
 serpin peptidase inhibitor, clade B (ovalbumin), member 8
 4105
 0.22
chrX_48796553_48796937 0.17 OTUD5
 OTU domain containing 5
 17706
 0.08
chr9_87905756_87905907 0.17 AGTPBP1
 ATP/GTP binding protein 1
 390370
 0.01
chr2_43397843_43397994 0.17 ZFP36L2
 ZFP36 ring finger protein-like 2
 55830
 0.13
chr5_39204147_39204382 0.17 FYB
 FYN binding protein
 1135
 0.63
chr21_34672110_34672341 0.17 IFNAR1
 interferon (alpha, beta and omega) receptor 1
 24509
 0.13
chr2_103059024_103059175 0.16 AC007278.3
3926
 0.17
chr1_36835365_36835563 0.16 STK40
 serine/threonine kinase 40
 8523
 0.13
chr1_27951892_27952043 0.16 FGR
 feline Gardner-Rasheed sarcoma viral oncogene homolog
 679
 0.61
chr14_92413353_92413602 0.16 FBLN5
 fibulin 5
 59
 0.98
chr7_45019149_45019431 0.16 MYO1G
 myosin IG
 593
 0.65
chr12_125473857_125474087 0.16 DHX37
 DEAH (Asp-Glu-Ala-His) box polypeptide 37
 305
 0.9
chr15_64665673_64665824 0.16 CTD-2116N17.1
 Uncharacterized protein
 163
 0.92
chr20_44833333_44833580 0.16 CDH22
 cadherin 22, type 2
 46878
 0.14
chr20_10485213_10485441 0.16 SLX4IP
 SLX4 interacting protein
 69376
 0.11
chrX_135826724_135826994 0.16 ARHGEF6
 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
 22643
 0.16
chr5_77224775_77224926 0.16 TBCA
 tubulin folding cofactor A
 60246
 0.14
chr3_182990531_182990717 0.16 B3GNT5
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
 7492
 0.21
chr7_148406333_148406484 0.16 CUL1
 cullin 1
 10404
 0.18
chr10_26729391_26729542 0.16 APBB1IP
 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
 2112
 0.43
chr6_166582383_166582539 0.16 T
 T, brachyury homolog (mouse)
 273
 0.93
chr16_88751434_88751599 0.16 SNAI3-AS1
 SNAI3 antisense RNA 1
 25
 0.93
chr10_101288694_101289161 0.16 RP11-129J12.2
1727
 0.34
chr6_147091501_147091674 0.16 ADGB
 androglobin
 6
 0.99
chr6_128842055_128842211 0.16 PTPRK
 protein tyrosine phosphatase, receptor type, K
 263
 0.91
chr6_36818115_36818266 0.16 CPNE5
 copine V
 10412
 0.17
chr1_27683765_27684109 0.16 MAP3K6
 mitogen-activated protein kinase kinase kinase 6
 975
 0.41
chr15_99332143_99332351 0.16 ENSG00000264480
 .
 4592
 0.3
chr6_74230738_74230889 0.16 EEF1A1
 eukaryotic translation elongation factor 1 alpha 1
 72
 0.95
chr18_60988556_60988796 0.16 BCL2
 B-cell CLL/lymphoma 2
 1315
 0.41
chr6_53205632_53205819 0.16 ELOVL5
 ELOVL fatty acid elongase 5
 7862
 0.22
chr6_10656054_10656229 0.16 ENSG00000201048
 .
 18860
 0.13
chr17_43488233_43488428 0.16 ARHGAP27
 Rho GTPase activating protein 27
 538
 0.66
chr6_142987864_142988015 0.16 RP1-67K17.3
81641
 0.11
chr1_231893166_231893324 0.16 ENSG00000222986
 .
 86864
 0.09
chr11_48055026_48055177 0.16 AC103828.1
17694
 0.2
chr7_8218098_8218600 0.15 ENSG00000265212
 .
 23697
 0.19
chr6_108109017_108109337 0.15 SCML4
 sex comb on midleg-like 4 (Drosophila)
 15722
 0.26
chr21_43612105_43612375 0.15 ABCG1
 ATP-binding cassette, sub-family G (WHITE), member 1
 7559
 0.2
chr3_187675103_187675412 0.15 LPP
 LIM domain containing preferred translocation partner in lipoma
 195815
 0.03
chr20_5093353_5093504 0.15 TMEM230
 transmembrane protein 230
 29
 0.95
chr10_50380716_50380985 0.15 C10orf128
 chromosome 10 open reading frame 128
 15507
 0.17
chr5_67581048_67581199 0.15 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 3073
 0.38
chr15_41245906_41246096 0.15 CHAC1
 ChaC, cation transport regulator homolog 1 (E. coli)
 403
 0.79
chr16_57703759_57703957 0.15 GPR97
 G protein-coupled receptor 97
 1638
 0.28
chr16_30461637_30461788 0.15 ENSG00000202476
 .
 3706
 0.08
chr20_31139955_31140106 0.15 RP11-410N8.3
8865
 0.16
chr22_31619679_31619930 0.15 ENSG00000199695
 .
 965
 0.4
chr17_62067658_62067809 0.15 C17orf72
 chromosome 17 open reading frame 72
 7978
 0.14
chr1_167509501_167509771 0.15 CREG1
 cellular repressor of E1A-stimulated genes 1
 13368
 0.19
chr19_6668717_6669176 0.15 TNFSF14
 tumor necrosis factor (ligand) superfamily, member 14
 1182
 0.4
chr20_24026643_24026819 0.15 GGTLC1
 gamma-glutamyltransferase light chain 1
 57315
 0.15
chr7_92219738_92219889 0.15 FAM133B
 family with sequence similarity 133, member B
 105
 0.97
chr2_151344116_151344336 0.15 RND3
 Rho family GTPase 3
 17
 0.99
chr1_77513564_77513779 0.15 RP4-564M11.2
19934
 0.23
chr8_22929951_22930102 0.15 RP11-875O11.3
1975
 0.21
chr21_43319494_43319645 0.15 C2CD2
 C2 calcium-dependent domain containing 2
 2192
 0.23
chr18_60202275_60202426 0.15 ZCCHC2
 zinc finger, CCHC domain containing 2
 4397
 0.31
chr2_135008118_135008541 0.15 MGAT5
 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
 3501
 0.31
chr10_71108085_71108264 0.15 ENSG00000221774
 .
 15223
 0.17
chr7_38262255_38262771 0.15 STARD3NL
 STARD3 N-terminal like
 44516
 0.2
chr15_65567487_65567698 0.15 ENSG00000206903
 .
 10337
 0.12
chr12_9140443_9140771 0.15 KLRG1
 killer cell lectin-like receptor subfamily G, member 1
 1530
 0.35
chr13_73614878_73615077 0.15 KLF5
 Kruppel-like factor 5 (intestinal)
 14137
 0.24
chr12_9144662_9144957 0.15 KLRG1
 killer cell lectin-like receptor subfamily G, member 1
 143
 0.95

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of GZF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.1 0.3 GO:0009189 deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.1 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0 0.2 GO:0034227 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0 0.1 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.2 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.2 GO:0090322 regulation of superoxide metabolic process(GO:0090322)
0.0 0.2 GO:0090009 primitive streak formation(GO:0090009)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.0 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.1 GO:0046137 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.1 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0 0.1 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.0 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.0 0.1 GO:0030033 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.0 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.1 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.1 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.1 GO:0032632 interleukin-3 production(GO:0032632)
0.0 0.1 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0 0.1 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.0 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.1 GO:0048143 astrocyte activation(GO:0048143)
0.0 0.1 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0 0.1 GO:0017085 response to insecticide(GO:0017085)
0.0 0.0 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.0 0.1 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0 0.0 GO:0046476 glycosylceramide biosynthetic process(GO:0046476)
0.0 0.0 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:1904376 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.0 GO:0019322 pentose biosynthetic process(GO:0019322)
0.0 0.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.3 GO:0045730 respiratory burst(GO:0045730)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.0 0.0 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.0 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.0 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.0 GO:0035054 embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0 0.1 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.0 GO:0072311 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0051294 establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.0 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.0 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.0 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.0 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.1 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.0 GO:0061054 dermatome development(GO:0061054)
0.0 0.0 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.0 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.0 GO:0071436 sodium ion export(GO:0071436)
0.0 0.1 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.0 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.0 GO:0001865 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.1 GO:0014009 glial cell proliferation(GO:0014009)
0.0 0.1 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0 0.1 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 0.1 GO:0071333 cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.0 0.0 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.1 GO:0060347 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.0 GO:0097300 necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0 0.0 GO:0071801 regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0 0.1 GO:0071168 protein localization to chromatin(GO:0071168)
0.0 0.0 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.5 GO:0006968 cellular defense response(GO:0006968)
0.0 0.0 GO:0071637 heterotypic cell-cell adhesion(GO:0034113) regulation of heterotypic cell-cell adhesion(GO:0034114) monocyte chemotactic protein-1 production(GO:0071605) regulation of monocyte chemotactic protein-1 production(GO:0071637)
0.0 0.0 GO:0018101 protein citrullination(GO:0018101)
0.0 0.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.0 GO:0070295 renal water absorption(GO:0070295)
0.0 0.0 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.0 GO:0002674 negative regulation of acute inflammatory response(GO:0002674)
0.0 0.0 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.0 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.0 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.4 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0045118 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.2 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.1 GO:0031420 alkali metal ion binding(GO:0031420)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0070513 death domain binding(GO:0070513)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.0 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.0 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0016986 obsolete transcription initiation factor activity(GO:0016986)
0.0 0.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.0 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.0 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.0 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.0 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0022821 potassium ion antiporter activity(GO:0022821)
0.0 0.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.0 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.0 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.0 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.7 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.4 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.3 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.2 PID ARF 3PATHWAY Arf1 pathway
0.0 0.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.3 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.0 0.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.0 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.0 REACTOME AQUAPORIN MEDIATED TRANSPORT Genes involved in Aquaporin-mediated transport
0.0 0.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME CD28 CO STIMULATION Genes involved in CD28 co-stimulation
0.0 0.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.1 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.0 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.0 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.1 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane