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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HAND1

Z-value: 0.99

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Transcription factors associated with HAND1

Gene Symbol	Gene ID	Gene Info
HAND1 Ensembl NCBI GeneCards UniProt	ENSG00000113196.2	HAND1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HAND1	chr5_153900655_153900951	42979	0.133708	-0.73	2.6e-02	Click!
HAND1	chr5_153856378_153856529	1371	0.419329	0.72	2.8e-02	Click!
HAND1	chr5_153853814_153853984	3925	0.213488	0.55	1.2e-01	Click!
HAND1	chr5_153852765_153852916	4984	0.197080	0.53	1.5e-01	Click!
HAND1	chr5_153845026_153845177	12723	0.160774	-0.49	1.8e-01	Click!

Activity of the HAND1 motif across conditions

Conditions sorted by the z-value of the HAND1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_97009046_97009425	0.40	NCAPH	non-SMC condensin I complex, subunit H	7679	0.15
chr17_37252182_37252943	0.38	PLXDC1	plexin domain containing 1	11178	0.15
chr13_114892713_114893126	0.37	RASA3	RAS p21 protein activator 3	5108	0.24
chr11_4111133_4111394	0.36	RRM1	ribonucleotide reductase M1	4776	0.22
chr14_67948872_67949023	0.34	TMEM229B	transmembrane protein 229B	6502	0.18
chrX_47482564_47483099	0.34	SYN1	synapsin I	3579	0.15
chr4_15769645_15769984	0.34	CD38	CD38 molecule	10087	0.23
chr1_65342372_65342702	0.32	JAK1	Janus kinase 1	89650	0.08
chr1_28296104_28296455	0.31	RP11-460I13.2		9575	0.13
chr3_33472190_33472341	0.31	UBP1	upstream binding protein 1 (LBP-1a)	9237	0.21
chr8_93029450_93029601	0.31	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	66	0.98
chr12_104973749_104974059	0.31	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	8722	0.24
chr2_127418703_127419020	0.31	GYPC	glycophorin C (Gerbich blood group)	5101	0.3
chr5_14439836_14439987	0.31	TRIO	trio Rho guanine nucleotide exchange factor	48646	0.18
chr3_11677644_11677795	0.31	VGLL4	vestigial like 4 (Drosophila)	7679	0.22
chr6_126142988_126143327	0.31	NCOA7-AS1	NCOA7 antisense RNA 1	3153	0.24
chr1_198503645_198504115	0.30	ATP6V1G3	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	5924	0.32
chr3_113949300_113949543	0.29	ZNF80	zinc finger protein 80	7004	0.18
chr13_40762290_40762441	0.29	ENSG00000207458	.	38599	0.22
chr1_27076332_27076532	0.28	ENSG00000266138	.	13683	0.13
chr12_68176752_68176973	0.28	RP11-335O4.3		112163	0.07
chr16_67836589_67836775	0.28	RANBP10	RAN binding protein 10	3778	0.12
chr19_2775327_2775584	0.28	SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	4676	0.12
chr1_19768716_19768889	0.28	ENSG00000240490	.	17924	0.15
chr2_136578827_136578978	0.28	AC011893.3		1141	0.45
chr1_90064313_90064509	0.28	LRRC8B	leucine rich repeat containing 8 family, member B	30611	0.14
chr1_40137074_40137225	0.28	NT5C1A	5'-nucleotidase, cytosolic IA	561	0.66
chr1_221957617_221957791	0.27	DUSP10	dual specificity phosphatase 10	42186	0.19
chr1_221508301_221508621	0.27	DUSP10	dual specificity phosphatase 10	402341	0.01
chr6_112044961_112045268	0.27	FYN	FYN oncogene related to SRC, FGR, YES	3849	0.3
chr10_74923079_74923230	0.27	ECD	ecdysoneless homolog (Drosophila)	4663	0.12
chr6_109036108_109036376	0.27	FOXO3	forkhead box O3	58693	0.15
chr11_128396911_128397217	0.26	RP11-1007G5.2		1027	0.59
chr14_98675980_98676131	0.26	ENSG00000222066	.	122032	0.06
chr10_121044351_121044502	0.26	RP11-79M19.2		51268	0.11
chr17_34040072_34040441	0.26	RASL10B	RAS-like, family 10, member B	18412	0.11
chr7_8167446_8167940	0.26	AC006042.6		14038	0.21
chr3_16944411_16944593	0.26	PLCL2	phospholipase C-like 2	18050	0.23
chr2_47170482_47170698	0.25	MCFD2	multiple coagulation factor deficiency 2	1596	0.28
chr11_104670330_104670481	0.25	CASP12	caspase 12 (gene/pseudogene)	98736	0.08
chr13_110383641_110384047	0.25	LINC00676	long intergenic non-protein coding RNA 676	3215	0.35
chr2_98582630_98582781	0.25	TMEM131	transmembrane protein 131	29649	0.2
chr10_63840836_63841344	0.25	ARID5B	AT rich interactive domain 5B (MRF1-like)	32120	0.19
chr7_132116532_132116686	0.25	AC011625.1		79516	0.11
chr17_17084049_17084292	0.25	MPRIP	myosin phosphatase Rho interacting protein	1298	0.29
chr19_654179_654330	0.25	RNF126	ring finger protein 126	7148	0.09
chr1_229889719_229889932	0.24	URB2	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	103231	0.07
chr2_38925814_38925965	0.24	GALM	galactose mutarotase (aldose 1-epimerase)	17452	0.16
chr9_123679203_123679400	0.24	TRAF1	TNF receptor-associated factor 1	2451	0.31
chr11_60755747_60755977	0.24	ENSG00000207153	.	3223	0.16
chr1_54744952_54745103	0.24	RP5-997D24.3		6051	0.18
chr3_187897306_187897937	0.23	AC022498.1	Uncharacterized protein	1290	0.5
chrX_44125263_44125482	0.23	EFHC2	EF-hand domain (C-terminal) containing 2	77546	0.11
chr14_61984119_61984270	0.23	RP11-47I22.4		11652	0.2
chr7_2178117_2178407	0.23	MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	29026	0.21
chr3_134385868_134386019	0.23	KY	kyphoscoliosis peptidase	16079	0.23
chr14_92341016_92341177	0.23	FBLN5	fibulin 5	3290	0.26
chr7_640540_641424	0.23	PRKAR1B	protein kinase, cAMP-dependent, regulatory, type I, beta	1338	0.36
chrX_19778652_19778939	0.23	SH3KBP1	SH3-domain kinase binding protein 1	12974	0.29
chr4_73932257_73932427	0.23	COX18	COX18 cytochrome C oxidase assembly factor	3067	0.32
chr2_30488933_30489313	0.23	LBH	limb bud and heart development	34077	0.19
chr9_131832251_131832515	0.23	DOLPP1	dolichyldiphosphatase 1	10996	0.11
chr8_125649609_125649792	0.23	RP11-532M24.1		57828	0.12
chr2_99323973_99324148	0.23	MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	19099	0.21
chr2_175644427_175644584	0.23	CHRNA1	cholinergic receptor, nicotinic, alpha 1 (muscle)	15305	0.23
chr1_207098582_207098736	0.23	FAIM3	Fas apoptotic inhibitory molecule 3	2067	0.25
chr3_10284470_10284734	0.22	TATDN2	TatD DNase domain containing 2	5105	0.14
chr5_110590081_110590232	0.22	AC010468.2		15631	0.2
chr6_12163632_12164063	0.22	HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	37868	0.22
chr2_45029072_45029470	0.22	ENSG00000252896	.	20002	0.27
chr3_15359672_15359823	0.22	ENSG00000238891	.	1620	0.31
chr2_109790847_109791252	0.22	ENSG00000264934	.	33005	0.2
chr16_16135222_16135434	0.22	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	31615	0.19
chr1_206752443_206752919	0.22	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	22188	0.14
chr2_12644304_12644548	0.22	ENSG00000207183	.	92799	0.09
chr8_12860265_12860557	0.22	ENSG00000206996	.	41448	0.16
chr17_26134829_26135084	0.22	NOS2	nitric oxide synthase 2, inducible	7431	0.21
chr9_132033309_132033483	0.22	ENSG00000220992	.	40400	0.13
chr17_75452925_75453139	0.22	SEPT9	septin 9	584	0.7
chr11_128290296_128290447	0.21	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	84918	0.1
chr14_104383228_104383519	0.21	C14orf2	chromosome 14 open reading frame 2	4458	0.17
chr3_15578936_15579113	0.21	COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	15766	0.14
chr4_90600499_90600650	0.21	RP11-115D19.1		2089	0.47
chr17_14106066_14106394	0.21	AC005224.2		7575	0.21
chr11_68272006_68272464	0.21	ENSG00000222339	.	884	0.48
chr2_144302669_144302857	0.21	RP11-570L15.2		26911	0.19
chr10_15212970_15213280	0.21	NMT2	N-myristoyltransferase 2	2433	0.32
chr3_38539403_38539554	0.21	EXOG	endo/exonuclease (5'-3'), endonuclease G-like	1506	0.38
chrX_78420820_78421003	0.21	GPR174	G protein-coupled receptor 174	5558	0.35
chr18_2702393_2702544	0.21	SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1	46582	0.11
chrX_19766528_19766693	0.21	SH3KBP1	SH3-domain kinase binding protein 1	789	0.77
chr3_177661794_177662251	0.21	ENSG00000199858	.	63545	0.15
chr2_190149930_190150081	0.21	ENSG00000266817	.	26482	0.23
chr4_48344741_48344971	0.21	SLAIN2	SLAIN motif family, member 2	1517	0.49
chr11_65870833_65870984	0.20	PACS1	phosphofurin acidic cluster sorting protein 1	2674	0.17
chr3_119732053_119732204	0.20	GSK3B	glycogen synthase kinase 3 beta	80385	0.09
chr17_75960444_75960595	0.20	TNRC6C	trinucleotide repeat containing 6C	39730	0.14
chr12_52654824_52655351	0.20	KRT121P	keratin 121 pseudogene	2436	0.15
chr1_32667214_32667874	0.20	CCDC28B	coiled-coil domain containing 28B	1310	0.22
chr11_69519758_69519936	0.20	FGF19	fibroblast growth factor 19	437	0.84
chr8_71580114_71580327	0.20	LACTB2	lactamase, beta 2	1172	0.34
chr3_16865405_16865955	0.20	PLCL2	phospholipase C-like 2	60772	0.14
chr22_37226429_37226580	0.20	PVALB	parvalbumin	10981	0.13
chr2_144301655_144301806	0.20	RP11-570L15.2		27944	0.19
chr15_65574741_65574985	0.20	ENSG00000206903	.	3066	0.17
chr1_167604982_167605729	0.20	RP3-455J7.4		5444	0.21
chr9_139298829_139298980	0.20	SDCCAG3	serologically defined colon cancer antigen 3	2733	0.14
chr5_34570275_34570426	0.19	RAI14	retinoic acid induced 14	85992	0.09
chr10_35808142_35808293	0.19	GJD4	gap junction protein, delta 4, 40.1kDa	86121	0.08
chr10_127824965_127825297	0.19	ENSG00000222740	.	9020	0.29
chr14_98677293_98677464	0.19	ENSG00000222066	.	120709	0.06
chr7_47791048_47791199	0.19	LINC00525	long intergenic non-protein coding RNA 525	9951	0.23
chr10_111776497_111776648	0.19	ADD3	adducin 3 (gamma)	8850	0.21
chr10_11358280_11358431	0.19	CELF2-AS1	CELF2 antisense RNA 1	3492	0.36
chr4_6919752_6920098	0.19	TBC1D14	TBC1 domain family, member 14	7950	0.19
chr19_7581365_7581909	0.19	ZNF358	zinc finger protein 358	633	0.51
chr20_39775264_39775450	0.19	RP1-1J6.2		8714	0.2
chr12_104977859_104978010	0.19	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	4692	0.26
chr9_18385263_18385414	0.19	ADAMTSL1	ADAMTS-like 1	88554	0.1
chr12_111893200_111893523	0.19	ATXN2	ataxin 2	555	0.76
chr14_62543804_62543955	0.19	RP11-355I22.7		33714	0.23
chr15_101303814_101303965	0.19	ALDH1A3	aldehyde dehydrogenase 1 family, member A3	114030	0.05
chr16_29988360_29988511	0.19	TAOK2	TAO kinase 2	2833	0.11
chr6_37471487_37471725	0.19	CCDC167	coiled-coil domain containing 167	3908	0.25
chr2_42332803_42333174	0.18	PKDCC	protein kinase domain containing, cytoplasmic	57828	0.11
chr10_105208792_105209256	0.18	RP11-225H22.7		929	0.37
chr8_8704312_8704638	0.18	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	46680	0.14
chr14_98909850_98910089	0.18	ENSG00000241757	.	91968	0.09
chr12_12016346_12017014	0.18	ETV6	ets variant 6	22191	0.26
chr7_134512686_134512837	0.18	CALD1	caldesmon 1	15874	0.27
chr3_43359417_43359828	0.18	ENSG00000241939	.	3179	0.23
chr11_118567796_118568096	0.18	ENSG00000207462	.	5105	0.14
chr1_32730988_32731377	0.18	LCK	lymphocyte-specific protein tyrosine kinase	8532	0.09
chr9_137285314_137285572	0.18	RXRA	retinoid X receptor, alpha	12985	0.22
chr7_105537147_105537368	0.18	ATXN7L1	ataxin 7-like 1	20207	0.25
chr15_48931540_48931691	0.18	FBN1	fibrillin 1	6303	0.29
chr14_72908650_72908927	0.18	RGS6	regulator of G-protein signaling 6	12440	0.31
chr15_70196429_70196590	0.18	ENSG00000215958	.	118666	0.06
chr8_117744312_117744463	0.18	EIF3H	eukaryotic translation initiation factor 3, subunit H	23636	0.2
chr19_44436594_44436745	0.18	ZNF45	zinc finger protein 45	2742	0.17
chr10_112431690_112431897	0.18	RBM20	RNA binding motif protein 20	27638	0.14
chr20_55036334_55036485	0.18	ENSG00000212084	.	996	0.44
chr7_24600789_24600940	0.18	MPP6	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	12023	0.24
chr15_42068094_42068245	0.18	MAPKBP1	mitogen-activated protein kinase binding protein 1	1269	0.33
chr15_100782496_100782647	0.18	ADAMTS17	ADAM metallopeptidase with thrombospondin type 1 motif, 17	98770	0.07
chr2_143898363_143898928	0.18	ARHGAP15	Rho GTPase activating protein 15	11762	0.25
chr11_587585_588264	0.18	PHRF1	PHD and ring finger domains 1	11403	0.07
chr1_25800396_25800562	0.18	TMEM57	transmembrane protein 57	43068	0.11
chr2_225810689_225810885	0.18	DOCK10	dedicator of cytokinesis 10	995	0.69
chr12_76945362_76945546	0.18	OSBPL8	oxysterol binding protein-like 8	7830	0.32
chr6_45705684_45705835	0.18	ENSG00000252738	.	91918	0.09
chrY_22739941_22740092	0.18	EIF1AY	eukaryotic translation initiation factor 1A, Y-linked	2336	0.46
chrX_64901581_64901971	0.18	MSN	moesin	14239	0.29
chr1_90126896_90127047	0.18	LRRC8C	leucine rich repeat containing 8 family, member C	28340	0.15
chr5_171579294_171579519	0.18	STK10	serine/threonine kinase 10	35984	0.15
chr8_126946234_126946440	0.18	ENSG00000206695	.	33142	0.25
chr2_28624680_28624911	0.18	RP11-373D23.2		5113	0.18
chr14_22972883_22973034	0.18	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	16787	0.09
chr17_64371368_64371623	0.18	ENSG00000244044	.	11348	0.22
chr11_75040450_75040782	0.17	ENSG00000199090	.	5614	0.16
chr2_235388644_235388795	0.17	ARL4C	ADP-ribosylation factor-like 4C	16525	0.3
chr1_161167348_161167499	0.17	ADAMTS4	ADAM metallopeptidase with thrombospondin type 1 motif, 4	1420	0.16
chr1_198713615_198713766	0.17	RP11-553K8.5		77500	0.1
chr4_122087583_122087734	0.17	TNIP3	TNFAIP3 interacting protein 3	2163	0.36
chr22_24868016_24868188	0.17	UPB1	ureidopropionase, beta	4896	0.18
chr14_103249481_103249632	0.17	TRAF3	TNF receptor-associated factor 3	5601	0.2
chrX_100877410_100877579	0.17	ARMCX3	armadillo repeat containing, X-linked 3	293	0.8
chr14_99647460_99647611	0.17	AL162151.4		22782	0.23
chr18_9090620_9090967	0.17	NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	11835	0.18
chr12_15791050_15791201	0.17	EPS8	epidermal growth factor receptor pathway substrate 8	24083	0.2
chr10_104022395_104022570	0.17	ENSG00000251989	.	1495	0.33
chr20_44509042_44509193	0.17	ZSWIM1	zinc finger, SWIM-type containing 1	749	0.41
chr20_2722949_2723333	0.17	EBF4	early B-cell factor 4	36254	0.09
chr20_18523568_18523719	0.17	SEC23B	Sec23 homolog B (S. cerevisiae)	631	0.61
chr5_133478997_133479191	0.17	TCF7	transcription factor 7 (T-cell specific, HMG-box)	611	0.75
chr4_10621970_10622121	0.17	CLNK	cytokine-dependent hematopoietic cell linker	36140	0.23
chr1_233416939_233417108	0.17	PCNXL2	pecanex-like 2 (Drosophila)	14436	0.26
chrX_68051807_68052101	0.17	EFNB1	ephrin-B1	3114	0.39
chr4_108978798_108979031	0.17	HADH	hydroxyacyl-CoA dehydrogenase	53123	0.13
chr6_35278431_35279308	0.17	DEF6	differentially expressed in FDCP 6 homolog (mouse)	1354	0.42
chr9_92043695_92043846	0.17	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	7608	0.26
chr15_33321925_33322076	0.17	FMN1	formin 1	38085	0.18
chr6_24893842_24894069	0.17	FAM65B	family with sequence similarity 65, member B	16372	0.2
chr1_167472608_167472887	0.17	CD247	CD247 molecule	15028	0.19
chr2_113938283_113938445	0.17	AC016683.5		5427	0.15
chr5_130613594_130613745	0.17	CDC42SE2	CDC42 small effector 2	13876	0.28
chr17_42085806_42085957	0.17	NAGS	N-acetylglutamate synthase	3756	0.12
chr1_224570147_224570348	0.16	ENSG00000266618	.	15766	0.14
chr1_109048430_109048671	0.16	FAM102B	family with sequence similarity 102, member B	54161	0.13
chr19_8676942_8677296	0.16	ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif, 10	1534	0.33
chr6_139467698_139467849	0.16	HECA	headcase homolog (Drosophila)	11524	0.25
chr18_36157629_36157780	0.16	ENSG00000222704	.	438604	0.01
chr14_69950322_69950473	0.16	PLEKHD1	pleckstrin homology domain containing, family D (with coiled-coil domains) member 1	1074	0.6
chr15_66152500_66152651	0.16	RAB11A	RAB11A, member RAS oncogene family	9219	0.19
chr1_52258333_52258484	0.16	RP4-657D16.3		1229	0.38
chr9_123665604_123665920	0.16	TRAF1	TNF receptor-associated factor 1	11088	0.19
chr6_156342570_156342721	0.16	ENSG00000221456	.	74714	0.13
chr14_71276715_71276967	0.16	MAP3K9	mitogen-activated protein kinase kinase kinase 9	590	0.84
chr1_157083117_157083268	0.16	ETV3L	ets variant 3-like	13592	0.19
chr20_25022537_25022783	0.16	ACSS1	acyl-CoA synthetase short-chain family member 1	9321	0.2

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HAND1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0070670	response to interleukin-4(GO:0070670)
0.1	0.2	GO:1904251	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.1	0.2	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.2	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.3	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:0003283	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.2	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:0051892	negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.1	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0034776	response to histamine(GO:0034776)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.1	GO:2000351	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.0	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.0	GO:0070933	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.0	GO:0002251	organ or tissue specific immune response(GO:0002251)
0.0	0.1	GO:0015853	adenine transport(GO:0015853)
0.0	0.1	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.3	GO:0051806	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.5	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.0	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.0	GO:0002227	innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385)
0.0	0.1	GO:0046668	regulation of retinal cell programmed cell death(GO:0046668)
0.0	0.0	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.0	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.1	GO:0043383	negative T cell selection(GO:0043383)
0.0	0.0	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0031062	positive regulation of histone methylation(GO:0031062)
0.0	0.0	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.0	GO:0045915	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0	0.0	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.1	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.2	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.0	0.0	GO:0071428	rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0	0.0	GO:0002604	dendritic cell antigen processing and presentation(GO:0002468) regulation of dendritic cell antigen processing and presentation(GO:0002604) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.1	GO:0010901	regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
0.0	0.0	GO:1900120	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.0	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.0	GO:0042984	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.0	GO:0006222	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.1	GO:0006105	succinate metabolic process(GO:0006105)
0.0	0.1	GO:0051657	maintenance of organelle location(GO:0051657)
0.0	0.0	GO:0060677	ureteric bud elongation(GO:0060677)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0051194	positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of nucleoside metabolic process(GO:0045979) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197) positive regulation of ATP metabolic process(GO:1903580)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.0	GO:0033084	regulation of immature T cell proliferation in thymus(GO:0033084)
0.0	0.1	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
0.0	0.1	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.2	GO:0031648	protein destabilization(GO:0031648)
0.0	0.1	GO:0045885	obsolete positive regulation of survival gene product expression(GO:0045885)
0.0	0.0	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.0	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0034379	very-low-density lipoprotein particle assembly(GO:0034379)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.0	0.0	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.0	GO:2000758	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.0	0.3	GO:0043484	regulation of RNA splicing(GO:0043484)
0.0	0.0	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.1	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.0	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.3	GO:0051101	regulation of DNA binding(GO:0051101)
0.0	0.1	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.1	GO:0048679	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0051546	keratinocyte migration(GO:0051546)
0.0	0.0	GO:1902339	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.0	GO:0071803	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.1	GO:0042249	establishment of planar polarity of embryonic epithelium(GO:0042249)
0.0	0.0	GO:0032691	negative regulation of interleukin-1 beta production(GO:0032691) negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.0	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.1	GO:0051057	positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.0	0.0	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0042117	monocyte activation(GO:0042117)
0.0	0.0	GO:0071816	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0051001	negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0	0.0	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.0	GO:0061316	canonical Wnt signaling pathway involved in heart development(GO:0061316)
0.0	0.0	GO:0005984	disaccharide metabolic process(GO:0005984)
0.0	0.0	GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145)
0.0	0.1	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.0	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0050710	negative regulation of cytokine secretion(GO:0050710)
0.0	0.0	GO:0031167	rRNA methylation(GO:0031167)
0.0	0.0	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.0	GO:0002577	regulation of antigen processing and presentation(GO:0002577) positive regulation of antigen processing and presentation(GO:0002579)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.0	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.1	GO:0042533	tumor necrosis factor biosynthetic process(GO:0042533) regulation of tumor necrosis factor biosynthetic process(GO:0042534)
0.0	0.0	GO:0040009	regulation of growth rate(GO:0040009)
0.0	0.0	GO:1900619	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.2	GO:0030127	COPII vesicle coat(GO:0030127)
0.2	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	GO:0042584	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.2	GO:0001772	immunological synapse(GO:0001772)
0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1	GO:0005883	neurofilament(GO:0005883)
0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	GO:0042629	mast cell granule(GO:0042629)
0.1	GO:0030904	retromer complex(GO:0030904)
0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.1	GO:0000796	condensin complex(GO:0000796)
0.1	GO:0001527	microfibril(GO:0001527)
0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	GO:0031304	intrinsic component of mitochondrial inner membrane(GO:0031304)
0.1	GO:0071203	WASH complex(GO:0071203)
0.0	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	GO:0005899	insulin receptor complex(GO:0005899)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.1	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0019956	chemokine binding(GO:0019956)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.0	GO:1901474	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.2	GO:0015278	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.1	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.3	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.0	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.0	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.0	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.0	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.0	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.0	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.0	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.0	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.0	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.0	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.0	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.0	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.4	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.2	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.2	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.0	GO:0034618	arginine binding(GO:0034618)
0.0	0.0	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.0	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.0	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.4	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.6	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.8	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.2	PID CD40 PATHWAY	CD40/CD40L signaling
0.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	0.5	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.6	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.0	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.0	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.0	0.1	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.0	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.1	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.2	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.0	0.3	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.1	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.0	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0	0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.1	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.0	0.2	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins