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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for HDX

Z-value: 2.26

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Transcription factors associated with HDX

Gene Symbol	Gene ID	Gene Info
HDX Ensembl NCBI GeneCards UniProt	ENSG00000165259.9	highly divergent homeobox

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chrX_83757144_83757379	HDX	138	0.592747	0.49	1.8e-01	Click!
chrX_83757689_83757840	HDX	277	0.521815	-0.45	2.2e-01	Click!
chrX_83757427_83757578	HDX	15	0.512642	-0.22	5.7e-01	Click!
chrX_83756437_83756588	HDX	887	0.451157	0.11	7.8e-01	Click!

Activity of the HDX motif across conditions

Conditions sorted by the z-value of the HDX motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr21_34085576_34085727	1.43	SYNJ1	synaptojanin 1	13555	0.15
chr21_34085958_34086109	1.17	SYNJ1	synaptojanin 1	13173	0.15
chr11_36433312_36433542	1.00	PRR5L	proline rich 5 like	10812	0.18
chr1_198658673_198658824	1.00	RP11-553K8.5		22558	0.23
chr20_1602237_1602443	0.91	RP4-576H24.4	Uncharacterized protein	1685	0.24
chr2_162852542_162852808	0.88	AC008063.2		77091	0.09
chr16_11059004_11059432	0.88	CLEC16A	C-type lectin domain family 16, member A	20780	0.13
chrX_70318458_70318852	0.87	FOXO4	forkhead box O4	2276	0.17
chr3_13050762_13050913	0.87	IQSEC1	IQ motif and Sec7 domain 1	22301	0.24
chr5_67550264_67550491	0.87	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	14651	0.26
chr13_42968234_42968447	0.84	AKAP11	A kinase (PRKA) anchor protein 11	122051	0.06
chr11_47949983_47950362	0.79	PTPRJ	protein tyrosine phosphatase, receptor type, J	51941	0.12
chr5_49932475_49932649	0.78	PARP8	poly (ADP-ribose) polymerase family, member 8	29171	0.26
chr4_154730657_154731010	0.75	SFRP2	secreted frizzled-related protein 2	20561	0.19
chr2_182178443_182178616	0.75	ENSG00000266705	.	8150	0.32
chr2_169033675_169033826	0.73	STK39	serine threonine kinase 39	70901	0.13
chr4_149344107_149344258	0.73	NR3C2	nuclear receptor subfamily 3, group C, member 2	13830	0.3
chr13_41547224_41547475	0.73	ELF1	E74-like factor 1 (ets domain transcription factor)	9069	0.2
chr5_142789348_142789499	0.72	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	4535	0.34
chr3_43079553_43079704	0.72	FAM198A	family with sequence similarity 198, member A	58588	0.1
chr7_114660359_114660758	0.71	MDFIC	MyoD family inhibitor domain containing	86634	0.1
chr11_128162482_128162771	0.70	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	212663	0.02
chr10_11185263_11185615	0.70	CELF2	CUGBP, Elav-like family member 2	21554	0.19
chr15_63783171_63783387	0.70	USP3	ubiquitin specific peptidase 3	13514	0.23
chr8_125575470_125576116	0.69	MTSS1	metastasis suppressor 1	2175	0.26
chr17_15495175_15495615	0.69	CDRT1	CMT1A duplicated region transcript 1	1327	0.34
chr1_111689880_111690031	0.68	CEPT1	choline/ethanolamine phosphotransferase 1	7107	0.14
chr17_33585969_33586120	0.67	SLFN5	schlafen family member 5	15936	0.14
chrX_40030001_40030215	0.66	BCOR	BCL6 corepressor	6465	0.32
chr3_136639103_136639532	0.66	NCK1	NCK adaptor protein 1	7564	0.2
chr7_150443855_150444311	0.65	GIMAP5	GTPase, IMAP family member 5	9647	0.16
chr7_50320921_50321337	0.65	IKZF1	IKAROS family zinc finger 1 (Ikaros)	23195	0.25
chr7_3048587_3048738	0.64	ENSG00000201794	.	9934	0.23
chr19_19710111_19710297	0.64	AC002306.1		6955	0.12
chr7_129545877_129546028	0.64	UBE2H	ubiquitin-conjugating enzyme E2H	45215	0.1
chr14_20442882_20443033	0.64	OR4K15	olfactory receptor, family 4, subfamily K, member 15	646	0.64
chr1_207307763_207307914	0.64	C4BPA	complement component 4 binding protein, alpha	30187	0.15
chr14_75900699_75900850	0.63	JDP2	Jun dimerization protein 2	1937	0.33
chr4_36269076_36269227	0.63	RP11-431M7.3		11011	0.2
chr1_111731976_111732240	0.63	RP5-1180E21.5		4425	0.14
chr20_57695964_57696140	0.62	ZNF831	zinc finger protein 831	70023	0.09
chr9_116280263_116280484	0.62	RGS3	regulator of G-protein signaling 3	823	0.68
chr5_130405277_130405629	0.62	HINT1	histidine triad nucleotide binding protein 1	92867	0.09
chr1_100823290_100823730	0.62	CDC14A	cell division cycle 14A	5005	0.21
chr1_205575143_205575294	0.61	ENSG00000206762	.	11049	0.15
chr2_162807979_162808245	0.61	ENSG00000253046	.	32820	0.21
chr5_96139289_96139440	0.61	CTD-2260A17.3		692	0.61
chr12_14588679_14588830	0.61	ATF7IP	activating transcription factor 7 interacting protein	12059	0.23
chr11_47936391_47936542	0.60	PTPRJ	protein tyrosine phosphatase, receptor type, J	65647	0.09
chr14_68749508_68749848	0.60	ENSG00000243546	.	46422	0.17
chr5_158603640_158603791	0.60	RNF145	ring finger protein 145	30927	0.15
chr17_38768487_38768663	0.60	SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	19967	0.13
chr2_198131017_198131373	0.59	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	36048	0.14
chr4_15768202_15768353	0.59	CD38	CD38 molecule	11624	0.22
chr1_212399114_212399334	0.59	PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	59655	0.1
chr8_66715380_66715659	0.59	PDE7A	phosphodiesterase 7A	14200	0.26
chr14_68760088_68760299	0.59	ENSG00000243546	.	56937	0.15
chrX_19854268_19854593	0.59	SH3KBP1	SH3-domain kinase binding protein 1	36561	0.2
chr10_107599753_107599904	0.58	ENSG00000207068	.	305411	0.01
chr3_187678021_187678172	0.58	LPP	LIM domain containing preferred translocation partner in lipoma	192976	0.03
chrX_106230754_106231110	0.58	MORC4	MORC family CW-type zinc finger 4	5638	0.26
chr8_101231809_101232060	0.58	ENSG00000199667	.	34568	0.13
chr1_200709003_200709249	0.58	CAMSAP2	calmodulin regulated spectrin-associated protein family, member 2	219	0.96
chr1_100908166_100908711	0.58	RP5-837M10.4		43115	0.14
chr5_94959224_94959533	0.58	GPR150	G protein-coupled receptor 150	3596	0.22
chr8_126937549_126937701	0.58	ENSG00000206695	.	24430	0.28
chr17_47811103_47811254	0.58	FAM117A	family with sequence similarity 117, member A	9289	0.15
chr11_118177987_118178215	0.57	CD3E	CD3e molecule, epsilon (CD3-TCR complex)	2487	0.19
chr4_108971239_108971469	0.57	HADH	hydroxyacyl-CoA dehydrogenase	45563	0.15
chr1_100917512_100917831	0.57	RP5-837M10.4		33882	0.17
chr5_14598149_14598547	0.57	FAM105A	family with sequence similarity 105, member A	16464	0.23
chr6_139601830_139602039	0.56	RP11-445F6.2		2310	0.31
chr15_93434922_93435306	0.56	CHD2	chromodomain helicase DNA binding protein 2	7944	0.19
chr3_16981270_16981749	0.56	ENSG00000264818	.	6821	0.24
chr5_180609174_180609509	0.56	CTC-338M12.5		9583	0.09
chr12_46632171_46632463	0.56	SLC38A1	solute carrier family 38, member 1	29167	0.24
chr2_232327933_232328303	0.56	NCL	nucleolin	286	0.82
chr20_50116677_50116828	0.56	NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	42506	0.17
chr5_77015099_77015250	0.56	TBCA	tubulin folding cofactor A	4032	0.32
chr14_96592527_96592755	0.56	ENSG00000221236	.	10547	0.18
chr10_27634072_27634223	0.55	ENSG00000207135	.	9611	0.19
chr1_206956376_206956527	0.55	IL10	interleukin 10	10612	0.16
chr10_6641390_6641541	0.55	PRKCQ	protein kinase C, theta	19202	0.29
chr9_98742828_98743012	0.55	ERCC6L2	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	7801	0.27
chr1_211780615_211780961	0.55	RP11-359E8.5		23721	0.15
chr2_69866079_69866236	0.55	AAK1	AP2 associated kinase 1	4629	0.24
chr4_48203549_48203887	0.55	ENSG00000202014	.	48267	0.12
chr8_80966732_80966883	0.55	MRPS28	mitochondrial ribosomal protein S28	24283	0.18
chr20_1344193_1344436	0.55	RP11-314N13.3		2048	0.25
chr9_110053568_110053785	0.55	RAD23B	RAD23 homolog B (S. cerevisiae)	6700	0.31
chr1_41160471_41160622	0.55	NFYC	nuclear transcription factor Y, gamma	2584	0.21
chr11_36434278_36434429	0.55	PRR5L	proline rich 5 like	11738	0.18
chr3_15843084_15843262	0.55	ANKRD28	ankyrin repeat domain 28	5145	0.24
chr22_20819732_20820026	0.55	ENSG00000255156	.	9719	0.1
chr2_172959606_172960051	0.54	DLX2	distal-less homeobox 2	7800	0.21
chr12_68024949_68025235	0.54	DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	17026	0.25
chr12_116647785_116648171	0.54	RP11-115H15.2		28878	0.17
chr7_139554493_139554816	0.54	TBXAS1	thromboxane A synthase 1 (platelet)	25544	0.23
chr22_45570848_45571064	0.54	CTA-268H5.12		3915	0.19
chr6_71360263_71360634	0.53	SMAP1	small ArfGAP 1	17031	0.26
chr10_120855557_120855892	0.53	FAM45A	family with sequence similarity 45, member A	7876	0.14
chr10_8449222_8449415	0.53	ENSG00000212505	.	249476	0.02
chr2_68606734_68606885	0.53	AC015969.3		14093	0.17
chr14_91501757_91501911	0.53	RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	24644	0.17
chr19_19176974_19177125	0.53	SLC25A42	solute carrier family 25, member 42	2241	0.21
chr2_44901800_44902050	0.53	ENSG00000252896	.	107344	0.07
chr1_203291434_203291646	0.53	ENSG00000202300	.	3313	0.22
chrX_78406329_78406539	0.53	GPR174	G protein-coupled receptor 174	20035	0.29
chr11_3918269_3918516	0.53	STIM1	stromal interaction molecule 1	6301	0.14
chr11_118087590_118088000	0.53	AMICA1	adhesion molecule, interacts with CXADR antigen 1	2189	0.24
chr5_156641801_156641952	0.53	CTB-4E7.1		9514	0.13
chr8_142114570_142114965	0.53	DENND3	DENN/MADD domain containing 3	12610	0.2
chr4_38456816_38456967	0.52	RP11-617D20.1		169305	0.03
chr11_36438099_36438541	0.52	RP11-219O3.2		9352	0.19
chr13_41532996_41533147	0.52	ELF1	E74-like factor 1 (ets domain transcription factor)	23347	0.16
chr9_79345873_79346024	0.52	PRUNE2	prune homolog 2 (Drosophila)	20795	0.21
chr1_112014892_112015096	0.52	C1orf162	chromosome 1 open reading frame 162	1420	0.25
chr11_73723870_73724108	0.52	UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	3509	0.2
chr12_50796054_50796251	0.52	LARP4	La ribonucleoprotein domain family, member 4	1176	0.48
chr10_64451243_64451462	0.52	ENSG00000263920	.	33407	0.18
chr4_103448528_103448679	0.51	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	24071	0.18
chr6_26406613_26406840	0.51	BTN3A1	butyrophilin, subfamily 3, member A1	4203	0.12
chr3_43341661_43341812	0.51	SNRK	SNF related kinase	13658	0.17
chr9_107910216_107910462	0.51	ENSG00000201583	.	51302	0.16
chrX_40499635_40499786	0.51	CXorf38	chromosome X open reading frame 38	7063	0.22
chr7_155449708_155449859	0.51	RBM33	RNA binding motif protein 33	12387	0.21
chrX_8955459_8955610	0.51	FAM9B	family with sequence similarity 9, member B	45582	0.2
chr2_191929273_191929916	0.51	ENSG00000231858	.	43342	0.12
chr15_63825751_63825933	0.50	USP3	ubiquitin specific peptidase 3	1137	0.54
chr13_25200724_25201013	0.50	ENSG00000211508	.	17651	0.18
chr4_13617345_13617663	0.50	BOD1L1	biorientation of chromosomes in cell division 1-like 1	11843	0.2
chr1_81678243_81678394	0.50	ENSG00000223026	.	39156	0.21
chrX_153323115_153323266	0.50	ENSG00000211524	.	37750	0.09
chrX_123219671_123219822	0.50	ENSG00000239058	.	47388	0.17
chr1_1109574_1109820	0.50	TTLL10	tubulin tyrosine ligase-like family, member 10	411	0.66
chr2_175446825_175447268	0.50	WIPF1	WAS/WASL interacting protein family, member 1	3271	0.21
chr19_54879768_54880096	0.50	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	2126	0.19
chr9_37085723_37085874	0.49	RP11-220I1.2		29689	0.15
chr3_52298408_52298580	0.49	ENSG00000199150	.	3885	0.1
chr9_77767662_77767852	0.49	ENSG00000200041	.	28780	0.16
chr11_128175433_128175800	0.49	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	199673	0.03
chrX_154116005_154116287	0.49	ENSG00000221533	.	413	0.67
chr21_32506457_32506683	0.49	TIAM1	T-cell lymphoma invasion and metastasis 1	4031	0.33
chr11_95420301_95420529	0.49	FAM76B	family with sequence similarity 76, member B	99554	0.08
chrX_154686345_154686835	0.49	ENSG00000221603	.	588	0.57
chr13_74672570_74672721	0.49	KLF12	Kruppel-like factor 12	35749	0.24
chr6_6593122_6593282	0.48	LY86	lymphocyte antigen 86	4300	0.27
chr13_100012790_100013013	0.48	ENSG00000207719	.	4516	0.25
chr2_68385602_68386003	0.48	PNO1	partner of NOB1 homolog (S. cerevisiae)	826	0.45
chr9_92141364_92141857	0.48	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	28565	0.19
chr6_157421825_157422002	0.48	RP1-137K2.2		18927	0.25
chr1_169664801_169665268	0.48	SELL	selectin L	15805	0.19
chr12_68025335_68025706	0.48	DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	16598	0.25
chr17_1100600_1101315	0.47	ABR	active BCR-related	10341	0.19
chr17_262742_262893	0.47	AC108004.3		997	0.44
chr2_25516869_25517568	0.47	ENSG00000221445	.	34372	0.16
chr15_92470898_92471049	0.47	SLCO3A1	solute carrier organic anion transporter family, member 3A1	73622	0.12
chr1_169660668_169660923	0.47	SELL	selectin L	20044	0.18
chr7_138783506_138783787	0.47	ZC3HAV1	zinc finger CCCH-type, antiviral 1	10454	0.21
chr1_110094975_110095126	0.47	GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	3817	0.12
chr6_159530690_159531010	0.47	RP11-13P5.2		57535	0.11
chr11_118085464_118085638	0.47	AMICA1	adhesion molecule, interacts with CXADR antigen 1	55	0.97
chr6_20181272_20181565	0.47	RP11-239H6.2		30900	0.19
chr2_46577756_46578032	0.47	EPAS1	endothelial PAS domain protein 1	53353	0.14
chr4_36242269_36242420	0.46	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	3217	0.26
chr10_6101868_6102200	0.46	IL2RA	interleukin 2 receptor, alpha	2219	0.25
chr12_15106372_15106523	0.46	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	2362	0.25
chr9_88953538_88953925	0.46	ZCCHC6	zinc finger, CCHC domain containing 6	4307	0.27
chr15_60267965_60268474	0.46	FOXB1	forkhead box B1	28202	0.25
chr3_15562513_15562908	0.45	COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	533	0.72
chr11_6758586_6758829	0.45	GVINP1	GTPase, very large interferon inducible pseudogene 1	15596	0.12
chr14_60719501_60719652	0.45	PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A	2427	0.3
chr12_795549_795778	0.45	NINJ2	ninjurin 2	22718	0.17
chr1_160595319_160595764	0.45	SLAMF1	signaling lymphocytic activation molecule family member 1	21270	0.14
chr7_127427986_127428137	0.45	SND1	staphylococcal nuclease and tudor domain containing 1	99904	0.07
chr5_67534562_67534771	0.45	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	1060	0.63
chr5_112859873_112860055	0.45	YTHDC2	YTH domain containing 2	10121	0.2
chr20_50036283_50036434	0.45	ENSG00000266761	.	33156	0.19
chr1_20016120_20016277	0.45	HTR6	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	24418	0.16
chr15_60852222_60852373	0.45	CTD-2501E16.2		30125	0.16
chr3_107798287_107798438	0.45	CD47	CD47 molecule	11499	0.3
chr7_158616385_158616577	0.45	ESYT2	extended synaptotagmin-like protein 2	5682	0.26
chr7_36337294_36337445	0.45	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	616	0.72
chr16_27458426_27458577	0.45	IL21R-AS1	IL21R antisense RNA 1	6213	0.2
chr1_160535323_160535488	0.45	CD84	CD84 molecule	13858	0.13
chr5_101009129_101009280	0.45	ENSG00000264318	.	91670	0.1
chr20_47369313_47369511	0.44	ENSG00000251876	.	13427	0.27
chr2_48375694_48375845	0.44	ENSG00000201010	.	68945	0.13
chr5_52072365_52072556	0.44	ITGA1	integrin, alpha 1	11270	0.19
chrX_128916830_128917250	0.44	SASH3	SAM and SH3 domain containing 3	3080	0.26
chr5_169074930_169075085	0.44	DOCK2	dedicator of cytokinesis 2	10756	0.25
chr16_31881802_31882312	0.44	ZNF267	zinc finger protein 267	3022	0.3
chr11_114042469_114043098	0.44	ENSG00000221112	.	85132	0.08
chr2_101268394_101268545	0.44	ENSG00000265839	.	51141	0.13
chr17_4404014_4404514	0.44	AC118754.4		1295	0.31
chr10_74919029_74919180	0.44	ECD	ecdysoneless homolog (Drosophila)	8713	0.11
chr3_43340391_43340566	0.44	SNRK	SNF related kinase	12400	0.17
chr13_100511640_100511791	0.44	CLYBL	citrate lyase beta like	600	0.78
chr2_109227457_109227608	0.44	LIMS1	LIM and senescent cell antigen-like domains 1	3915	0.29
chr2_136964454_136964798	0.44	CXCR4	chemokine (C-X-C motif) receptor 4	88891	0.09

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0010459	negative regulation of heart rate(GO:0010459)
0.2	0.7	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.2	0.6	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.1	0.5	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.2	GO:0033622	integrin activation(GO:0033622)
0.1	0.9	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.3	GO:0018094	protein polyglycylation(GO:0018094)
0.1	0.3	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.2	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.1	0.5	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.1	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.1	0.2	GO:0045591	positive regulation of regulatory T cell differentiation(GO:0045591)
0.1	0.3	GO:0072600	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1	0.2	GO:1901419	regulation of response to alcohol(GO:1901419)
0.1	0.4	GO:0048488	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.1	0.2	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.3	GO:1900619	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.1	0.3	GO:0050932	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.1	1.0	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.1	0.2	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.2	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.1	0.4	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1	0.3	GO:0045059	positive thymic T cell selection(GO:0045059)
0.1	0.4	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.1	0.2	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.3	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.1	0.2	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.1	0.2	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.2	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1	0.2	GO:0097576	vacuole fusion(GO:0097576)
0.1	0.2	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.1	0.1	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.1	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.1	0.3	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1	0.3	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1	0.3	GO:0051569	regulation of histone H3-K4 methylation(GO:0051569)
0.1	0.3	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.1	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.1	0.5	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1	0.2	GO:0071481	cellular response to X-ray(GO:0071481)
0.1	0.2	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.1	0.2	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.1	0.2	GO:0071224	cellular response to peptidoglycan(GO:0071224)
0.1	0.2	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.2	GO:0060242	contact inhibition(GO:0060242)
0.1	0.3	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.1	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.1	0.3	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1	0.3	GO:0045354	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.1	0.1	GO:0033083	regulation of immature T cell proliferation(GO:0033083)
0.1	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	0.2	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1	0.3	GO:0002002	regulation of angiotensin levels in blood(GO:0002002)
0.1	0.2	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.1	0.2	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.1	0.2	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.0	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0033024	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.3	GO:0048715	negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0	0.2	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.2	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0003181	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.4	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.1	GO:0035609	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.5	GO:0014037	Schwann cell differentiation(GO:0014037)
0.0	0.1	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.2	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:1904063	negative regulation of calcium ion import(GO:0090281) negative regulation of cation transmembrane transport(GO:1904063)
0.0	0.3	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.2	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.3	GO:0060292	long term synaptic depression(GO:0060292)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.3	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.2	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.2	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.2	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.4	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.3	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.3	GO:0046348	amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.1	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0010823	negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0	0.2	GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.2	GO:0048070	regulation of developmental pigmentation(GO:0048070)
0.0	0.3	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.5	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.5	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.1	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.0	0.1	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.2	GO:0006590	thyroid hormone generation(GO:0006590)
0.0	0.2	GO:0034453	microtubule anchoring(GO:0034453)
0.0	0.1	GO:0002862	negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.2	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.1	GO:0072698	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.1	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.0	0.3	GO:0042130	negative regulation of T cell proliferation(GO:0042130)
0.0	0.1	GO:0046033	AMP metabolic process(GO:0046033)
0.0	0.1	GO:0061099	negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0	0.0	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0	0.3	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.1	GO:0016246	RNA interference(GO:0016246)
0.0	0.1	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:2000351	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.2	GO:0021683	cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.0	GO:0002839	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0	0.4	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.0	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934)
0.0	0.1	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.1	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0	0.0	GO:0010887	negative regulation of cholesterol storage(GO:0010887)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.1	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0042670	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0	0.3	GO:0043666	regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0	0.1	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.2	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.4	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.3	GO:0051806	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.3	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.2	GO:1903038	negative regulation of T cell activation(GO:0050868) negative regulation of leukocyte cell-cell adhesion(GO:1903038)
0.0	0.1	GO:0016999	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.0	GO:0002579	positive regulation of antigen processing and presentation(GO:0002579) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.2	GO:0016226	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.1	GO:0031442	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.2	GO:0032986	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:0017085	response to insecticide(GO:0017085)
0.0	0.1	GO:0031579	membrane raft organization(GO:0031579)
0.0	0.2	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.1	GO:0044803	multi-organism membrane organization(GO:0044803)
0.0	0.0	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0051459	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.1	GO:0051299	centrosome separation(GO:0051299)
0.0	0.0	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.0	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.0	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0045651	positive regulation of macrophage differentiation(GO:0045651)
0.0	0.4	GO:1905037	autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0	0.0	GO:0045423	regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.1	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.0	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.2	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.0	GO:0071637	monocyte chemotactic protein-1 production(GO:0071605) regulation of monocyte chemotactic protein-1 production(GO:0071637)
0.0	0.2	GO:0050718	positive regulation of interleukin-1 beta secretion(GO:0050718)
0.0	0.1	GO:0035066	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0090004	positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.0	0.0	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.0	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.4	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0002467	germinal center formation(GO:0002467)
0.0	0.2	GO:0000303	response to superoxide(GO:0000303)
0.0	0.0	GO:0072179	nephric duct formation(GO:0072179)
0.0	0.1	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.0	GO:0071372	cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0	0.1	GO:0034088	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.0	GO:0042362	fat-soluble vitamin biosynthetic process(GO:0042362)
0.0	0.8	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.1	GO:0031297	replication fork processing(GO:0031297)
0.0	0.1	GO:0006545	glycine biosynthetic process(GO:0006545)
0.0	0.1	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.0	0.0	GO:0090192	regulation of glomerulus development(GO:0090192)
0.0	0.2	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.0	GO:0060197	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.1	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.0	GO:0032203	telomere formation via telomerase(GO:0032203)
0.0	0.1	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0033261	obsolete regulation of S phase(GO:0033261)
0.0	0.1	GO:0030219	megakaryocyte differentiation(GO:0030219)
0.0	0.1	GO:1901538	DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.1	GO:0003077	obsolete negative regulation of diuresis(GO:0003077)
0.0	0.0	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0	0.0	GO:0002220	innate immune response activating cell surface receptor signaling pathway(GO:0002220)
0.0	0.0	GO:0034143	regulation of toll-like receptor 4 signaling pathway(GO:0034143)
0.0	0.0	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.0	GO:0043301	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0	0.1	GO:0032212	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0006210	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.0	GO:0045625	regulation of T-helper 1 cell differentiation(GO:0045625)
0.0	0.1	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.2	GO:0045725	positive regulation of glycogen biosynthetic process(GO:0045725)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.4	GO:0006829	zinc II ion transport(GO:0006829)
0.0	0.0	GO:0021781	glial cell fate commitment(GO:0021781)
0.0	0.0	GO:0045618	positive regulation of keratinocyte differentiation(GO:0045618)
0.0	0.0	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.2	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.0	GO:0048024	regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0	0.1	GO:1901998	tetracycline transport(GO:0015904) antibiotic transport(GO:0042891) toxin transport(GO:1901998)
0.0	0.3	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.0	0.0	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.1	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0	0.1	GO:0042772	DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.0	0.1	GO:0010225	response to UV-C(GO:0010225)
0.0	0.0	GO:0021778	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.0	GO:0002246	wound healing involved in inflammatory response(GO:0002246) inflammatory response to wounding(GO:0090594)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.0	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.1	GO:0038061	activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0	0.0	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.6	GO:0006635	fatty acid beta-oxidation(GO:0006635)
0.0	0.1	GO:0033363	secretory granule organization(GO:0033363)
0.0	0.0	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.0	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0	0.1	GO:0071168	protein localization to chromatin(GO:0071168)
0.0	0.2	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.2	GO:0045668	negative regulation of osteoblast differentiation(GO:0045668)
0.0	0.1	GO:0051205	protein insertion into membrane(GO:0051205)
0.0	0.2	GO:0006662	glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.0	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.1	GO:0048617	foregut morphogenesis(GO:0007440) embryonic foregut morphogenesis(GO:0048617)
0.0	0.2	GO:0032092	positive regulation of protein binding(GO:0032092)
0.0	0.1	GO:0036473	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.0	GO:0001832	blastocyst growth(GO:0001832)
0.0	0.1	GO:0019042	viral latency(GO:0019042)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.6	GO:0034339	obsolete regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor(GO:0034339)
0.0	0.0	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.1	GO:0015074	DNA integration(GO:0015074)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.1	GO:0090224	regulation of spindle organization(GO:0090224)
0.0	0.1	GO:0002717	positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0	0.0	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.5	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.0	0.0	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.0	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.2	GO:0045576	mast cell activation(GO:0045576)
0.0	0.2	GO:0006541	glutamine metabolic process(GO:0006541)
0.0	0.0	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.0	GO:0032747	interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.0	GO:0031054	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587) pre-miRNA processing(GO:0031054)
0.0	0.0	GO:0032354	response to follicle-stimulating hormone(GO:0032354)
0.0	0.0	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.1	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.0	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.4	GO:0070588	calcium ion transmembrane transport(GO:0070588)
0.0	0.0	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.1	GO:0034260	negative regulation of GTPase activity(GO:0034260)
0.0	0.2	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.0	GO:0032410	negative regulation of transporter activity(GO:0032410)
0.0	0.0	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.2	GO:0007030	Golgi organization(GO:0007030)
0.0	0.2	GO:0060330	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.0	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.0	GO:0045792	negative regulation of cell size(GO:0045792)
0.0	0.2	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.1	GO:0015851	nucleobase transport(GO:0015851)
0.0	0.1	GO:0031529	ruffle organization(GO:0031529)
0.0	0.0	GO:0032700	negative regulation of interleukin-17 production(GO:0032700)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0032876	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0098534	centriole replication(GO:0007099) centriole assembly(GO:0098534)
0.0	0.1	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.2	GO:0032480	negative regulation of type I interferon production(GO:0032480)
0.0	0.0	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.0	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.0	GO:0045351	type I interferon biosynthetic process(GO:0045351)
0.0	0.1	GO:0006621	protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0	0.0	GO:0090195	chemokine secretion(GO:0090195) regulation of chemokine secretion(GO:0090196) positive regulation of chemokine secretion(GO:0090197)
0.0	0.0	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.1	GO:0019720	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.1	GO:0033523	histone H2B ubiquitination(GO:0033523)
0.0	0.1	GO:0016056	rhodopsin mediated signaling pathway(GO:0016056)
0.0	0.1	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.0	GO:0051026	chiasma assembly(GO:0051026)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.3	GO:0046540	U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.1	0.3	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.8	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	0.3	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.1	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	0.8	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	0.7	GO:0001772	immunological synapse(GO:0001772)
0.1	0.3	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1	0.2	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.2	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.2	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.2	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.2	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0033150	cytoskeletal calyx(GO:0033150)
0.0	0.3	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.3	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.0	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.1	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.8	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.3	GO:0016235	aggresome(GO:0016235)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.3	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.1	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.1	GO:0001741	XY body(GO:0001741)
0.0	0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0034464	BBSome(GO:0034464)
0.0	0.1	GO:0070552	BRISC complex(GO:0070552)
0.0	0.5	GO:0048475	membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.2	GO:0035267	NuA4 histone acetyltransferase complex(GO:0035267)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.2	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.2	GO:0045120	pronucleus(GO:0045120)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.1	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.0	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0030914	STAGA complex(GO:0030914)
0.0	0.2	GO:0030897	HOPS complex(GO:0030897)
0.0	0.2	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0	0.2	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.1	GO:0043209	myelin sheath(GO:0043209)
0.0	0.3	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0042555	MCM complex(GO:0042555)
0.0	0.7	GO:0005905	clathrin-coated pit(GO:0005905)
0.0	0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	1.8	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	0.2	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.4	GO:0009295	nucleoid(GO:0009295)
0.0	0.1	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.0	0.2	GO:0043198	dendritic shaft(GO:0043198)
0.0	0.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.1	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.0	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.2	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.1	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.3	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	0.0	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.0	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.8	GO:0000790	nuclear chromatin(GO:0000790)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.0	GO:0001740	Barr body(GO:0001740)
0.0	0.0	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.2	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.3	GO:0005876	spindle microtubule(GO:0005876)
0.0	0.0	GO:0001652	granular component(GO:0001652)
0.0	0.0	GO:0072487	MSL complex(GO:0072487)
0.0	0.0	GO:0016589	NURF complex(GO:0016589)
0.0	0.1	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.0	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0000792	heterochromatin(GO:0000792)
0.0	0.0	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.4	GO:0042608	T cell receptor binding(GO:0042608)
0.1	0.4	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.1	0.3	GO:0070735	protein-glycine ligase activity(GO:0070735)
0.1	0.3	GO:0033691	sialic acid binding(GO:0033691)
0.1	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1	0.3	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.3	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	1.9	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.6	GO:0003785	actin monomer binding(GO:0003785)
0.1	0.2	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.1	0.7	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.1	0.2	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.1	0.2	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.1	0.2	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.4	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	0.2	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.1	0.9	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1	0.5	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.5	GO:0004950	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.2	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.1	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.7	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.6	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.2	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.2	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.3	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.3	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.3	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.3	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.3	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.5	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0035197	siRNA binding(GO:0035197)
0.0	0.2	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.2	GO:0004568	chitinase activity(GO:0004568)
0.0	0.2	GO:0010340	carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0	0.2	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.3	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.3	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.2	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.0	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.6	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.5	GO:0042162	telomeric DNA binding(GO:0042162)
0.0	0.3	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.2	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.3	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.2	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.3	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.2	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.8	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.5	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.1	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.6	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.5	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	0.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.4	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.2	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.0	GO:0046625	sphingolipid binding(GO:0046625)
0.0	0.1	GO:0000739	obsolete DNA strand annealing activity(GO:0000739)
0.0	0.1	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.2	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.0	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	1.0	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.5	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.8	GO:0101005	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.2	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.2	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.1	GO:0016530	metallochaperone activity(GO:0016530)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.0	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.1	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.2	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.2	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.2	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.1	GO:0003711	obsolete transcription elongation regulator activity(GO:0003711)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.4	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.0	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.3	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.7	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.5	GO:0030145	manganese ion binding(GO:0030145)
0.0	0.0	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.0	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.1	GO:0008493	tetracycline transporter activity(GO:0008493)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.0	GO:0004802	transketolase activity(GO:0004802)
0.0	0.0	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.4	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.7	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0016303	1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.2	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.0	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.1	GO:0099589	G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.0	0.5	GO:0042826	histone deacetylase binding(GO:0042826)
0.0	0.3	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.0	0.1	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0	0.8	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.1	GO:0031432	titin binding(GO:0031432)
0.0	0.1	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0004551	nucleotide diphosphatase activity(GO:0004551)
0.0	0.1	GO:0071617	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.3	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.1	GO:0046970	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.2	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.2	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.0	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.1	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.0	GO:0016160	alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.0	0.0	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.0	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
0.0	0.1	GO:0016502	purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.4	GO:0043021	ribonucleoprotein complex binding(GO:0043021)
0.0	0.0	GO:0035240	dopamine binding(GO:0035240)
0.0	0.1	GO:0090079	translation activator activity(GO:0008494) translation regulator activity, nucleic acid binding(GO:0090079)
0.0	0.0	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.1	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0	0.1	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.1	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.0	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.0	GO:0070008	serine-type exopeptidase activity(GO:0070008)
0.0	0.0	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.0	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0004952	dopamine neurotransmitter receptor activity(GO:0004952)
0.0	0.2	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.2	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.0	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.3	GO:0003823	antigen binding(GO:0003823)
0.0	0.0	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.2	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.0	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0001846	opsonin binding(GO:0001846)
0.0	0.0	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.0	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.0	GO:0001848	complement binding(GO:0001848)
0.0	0.0	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.1	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.2	GO:0002039	p53 binding(GO:0002039)
0.0	0.1	GO:0003840	gamma-glutamyltransferase activity(GO:0003840)
0.0	0.4	GO:0042393	histone binding(GO:0042393)
0.0	0.0	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.1	GO:0043560	insulin receptor substrate binding(GO:0043560)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	2.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	0.5	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	0.4	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.1	0.8	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	2.0	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	1.3	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	1.2	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.9	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	1.3	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	1.1	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.5	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.6	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.9	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.3	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.2	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.2	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.5	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.3	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.0	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.1	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.3	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.6	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.2	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.1	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.0	0.4	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.0	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.2	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	0.3	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.1	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	0.2	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.3	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	0.2	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.0	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.5	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.1	PID EPO PATHWAY	EPO signaling pathway
0.0	0.3	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.0	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.0	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.8	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	0.5	PID P53 REGULATION PATHWAY	p53 pathway
0.0	0.1	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	0.1	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	0.1	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.9	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	0.2	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	0.8	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	0.1	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	0.1	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.1	0.4	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.6	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.5	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.9	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	1.1	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.5	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.6	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.2	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0	0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.4	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.6	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.4	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.1	REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	Genes involved in Glucagon signaling in metabolic regulation
0.0	0.7	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.4	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.3	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.2	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.1	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	1.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.3	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.2	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling
0.0	0.4	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.3	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.0	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	1.0	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.3	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.3	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.6	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.2	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	0.2	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.7	REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.0	0.4	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.3	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.4	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0	0.1	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.3	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.0	0.3	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.5	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.1	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.0	0.2	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.0	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.0	0.1	REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	Genes involved in Processing of Capped Intronless Pre-mRNA
0.0	0.1	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.0	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.0	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.0	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.0	0.0	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.0	0.2	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	0.1	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0	0.2	REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0	0.3	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0	0.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.8	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.2	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.1	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.2	REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.2	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.1	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.1	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.3	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.2	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.0	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	0.1	REACTOME OPSINS	Genes involved in Opsins
0.0	0.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.1	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.0	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.0	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.1	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs

Results for HDX

Z-value: 2.26

Motif logo

Transcription factors associated with HDX

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the HDX motif across conditions

Conditions sorted by the z-value of the HDX motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: