CREMA results: HESX1

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Transcription factors associated with HESX1

Gene Symbol	Gene ID	Gene Info
HESX1 Ensembl NCBI GeneCards UniProt	ENSG00000163666.4	HESX homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr3_57230333_57230484	HESX1	3558	0.225511	0.62	7.2e-02	Click!
chr3_57233953_57234104	HESX1	45	0.975388	0.56	1.2e-01	Click!
chr3_57258671_57258822	HESX1	1803	0.314127	0.47	2.0e-01	Click!
chr3_57258884_57259035	HESX1	1590	0.344356	0.86	3.2e-03	Click!
chr3_57260204_57260355	HESX1	270	0.877603	0.35	3.6e-01	Click!

Showing 1 to 5 of 5 entries

Activity of the HESX1 motif across conditions

Conditions sorted by the z-value of the HESX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_2933384_2933685	0.65	SLC22A18AS	solute carrier family 22 (organic cation transporter), member 18 antisense	8564	0.12
chr2_232229722_232230070	0.44	ENSG00000263641	.	2477	0.26
chr18_9016875_9017135	0.41	NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	85623	0.08
chr2_87901691_87901863	0.39	ENSG00000265507	.	27497	0.24
chr5_145356260_145356548	0.39	SH3RF2	SH3 domain containing ring finger 2	38964	0.18
chr16_70780334_70780534	0.38	RP11-394B2.6		526	0.69
chr7_20447658_20447906	0.37	ENSG00000200753	.	30828	0.2
chrX_69697630_69697850	0.35	DLG3-AS1	DLG3 antisense RNA 1	21896	0.14
chr8_122360906_122361134	0.33	ENSG00000221644	.	161888	0.04
chr18_21464195_21464346	0.32	LAMA3	laminin, alpha 3	467	0.84

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HESX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	GO:0006446	regulation of translational initiation(GO:0006446)
0.1	0.4	GO:0010193	response to ozone(GO:0010193)
0.1	0.4	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1	0.4	GO:0009629	response to gravity(GO:0009629)
0.0	0.4	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.4	GO:0048008	platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0	0.4	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.1	0.3	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.3	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.1	0.3	GO:0048625	myoblast fate commitment(GO:0048625)

Showing 1 to 10 of 341 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	GO:0016459	myosin complex(GO:0016459)
0.0	0.6	GO:0030426	growth cone(GO:0030426)
0.0	0.5	GO:0005604	basement membrane(GO:0005604)
0.0	0.4	GO:0005811	lipid particle(GO:0005811)
0.0	0.4	GO:0016592	mediator complex(GO:0016592)
0.1	0.3	GO:0032059	bleb(GO:0032059)
0.0	0.3	GO:0005606	laminin-1 complex(GO:0005606)
0.1	0.2	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.2	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)

Showing 1 to 10 of 72 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.5	GO:0042809	vitamin D receptor binding(GO:0042809)
0.1	0.4	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.4	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.4	GO:0017166	vinculin binding(GO:0017166)
0.0	0.4	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.4	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.4	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.4	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.4	GO:0005518	collagen binding(GO:0005518)

Showing 1 to 10 of 212 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.8	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.7	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.6	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.5	ST GA12 PATHWAY	G alpha 12 Pathway
0.5	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.5	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.4	PID S1P S1P2 PATHWAY	S1P2 pathway

Showing 1 to 10 of 38 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
1.0	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.7	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.6	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.4	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.4	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions

Showing 1 to 10 of 55 entries

Results for HESX1

Z-value: 1.29

Motif logo

Transcription factors associated with HESX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the HESX1 motif across conditions

Conditions sorted by the z-value of the HESX1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HESX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: