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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HIF1A

Z-value: 0.76

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Transcription factors associated with HIF1A

Gene Symbol	Gene ID	Gene Info
HIF1A Ensembl NCBI GeneCards UniProt	ENSG00000100644.12	HIF1A

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HIF1A	chr14_62183724_62184123	19583	0.216505	-0.86	2.6e-03	Click!
HIF1A	chr14_62176844_62177091	12627	0.234024	-0.85	3.3e-03	Click!
HIF1A	chr14_62169999_62170295	5807	0.260531	-0.82	7.1e-03	Click!
HIF1A	chr14_62182699_62182850	18434	0.219529	-0.80	1.0e-02	Click!
HIF1A	chr14_62173062_62173362	8872	0.244524	-0.76	1.7e-02	Click!

Activity of the HIF1A motif across conditions

Conditions sorted by the z-value of the HIF1A motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr18_10726488_10726639	0.47	PIEZO2	piezo-type mechanosensitive ion channel component 2	21935	0.2
chr2_74648839_74648990	0.43	WDR54	WD repeat domain 54	57	0.67
chr8_61973816_61973967	0.40	CLVS1	clavesin 1	4174	0.36
chr4_82136461_82136814	0.38	PRKG2	protein kinase, cGMP-dependent, type II	419	0.89
chr9_93956113_93956298	0.35	AUH	AU RNA binding protein/enoyl-CoA hydratase	167972	0.04
chr9_138999867_139000258	0.34	C9orf69	chromosome 9 open reading frame 69	10058	0.19
chr11_133920937_133921088	0.32	JAM3	junctional adhesion molecule 3	17808	0.22
chr19_42391298_42391529	0.31	ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	2898	0.16
chr18_43913575_43913778	0.30	RNF165	ring finger protein 165	255	0.95
chr5_11384831_11385016	0.28	CTNND2	catenin (cadherin-associated protein), delta 2	204000	0.03
chr1_65533556_65533707	0.27	ENSG00000199135	.	9440	0.19
chrX_77359735_77359886	0.27	PGK1	phosphoglycerate kinase 1	58	0.98
chr16_68022948_68023099	0.27	DUS2	dihydrouridine synthase 2	1348	0.22
chr10_81002057_81002208	0.26	ZMIZ1	zinc finger, MIZ-type containing 1	63843	0.13
chr15_90606260_90606411	0.26	ZNF710	zinc finger protein 710	4911	0.16
chr18_51795667_51795818	0.24	POLI	polymerase (DNA directed) iota	32	0.98
chr7_44303433_44303584	0.24	CAMK2B	calcium/calmodulin-dependent protein kinase II beta	21603	0.17
chr19_41328238_41328415	0.23	EGLN2	egl-9 family hypoxia-inducible factor 2	15178	0.12
chr8_72755880_72756041	0.23	RP11-383H13.1	Protein LOC100132891; cDNA FLJ53548	164	0.88
chr5_43397167_43397386	0.22	CCL28	chemokine (C-C motif) ligand 28	90	0.97
chr4_187112479_187112630	0.22	AC110771.1	Uncharacterized protein	72	0.56
chr3_100240423_100240574	0.22	TMEM45A	transmembrane protein 45A	28994	0.2
chr3_133576348_133576499	0.21	RAB6B	RAB6B, member RAS oncogene family	37140	0.15
chr13_27936429_27936610	0.21	ENSG00000252247	.	18636	0.15
chr9_140051094_140051245	0.21	ENSG00000263697	.	12553	0.06
chr16_85590036_85590187	0.20	GSE1	Gse1 coiled-coil protein	54904	0.13
chr21_39850220_39850518	0.20	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	19976	0.28
chr16_3766966_3767153	0.20	TRAP1	TNF receptor-associated protein 1	455	0.82
chr7_95100446_95100597	0.20	ASB4	ankyrin repeat and SOCS box containing 4	14692	0.17
chr2_232505608_232505920	0.20	ENSG00000239202	.	5220	0.2
chr6_139695018_139695224	0.20	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	229	0.96
chr8_126614315_126614538	0.20	ENSG00000266452	.	157619	0.04
chr14_34407515_34407805	0.20	EGLN3	egl-9 family hypoxia-inducible factor 3	12372	0.25
chr19_2288228_2288485	0.20	LINGO3	leucine rich repeat and Ig domain containing 3	3667	0.1
chr17_75317312_75317463	0.20	SEPT9	septin 9	992	0.6
chr5_10746814_10746997	0.20	CTD-2154B17.4		14272	0.22
chr1_36040729_36040916	0.20	RP4-728D4.2		1474	0.29
chr17_38511467_38511733	0.20	CTD-2267D19.3	Uncharacterized protein	5307	0.11
chr8_130722541_130722692	0.19	GSDMC	gasdermin C	76518	0.1
chr19_55670752_55670903	0.19	CTD-2587H24.5		520	0.5
chr14_64804805_64805119	0.19	ESR2	estrogen receptor 2 (ER beta)	132	0.76
chr9_134901891_134902042	0.18	MED27	mediator complex subunit 27	53287	0.16
chr4_2044269_2044420	0.18	C4orf48	chromosome 4 open reading frame 48	567	0.49
chr8_145698238_145698394	0.18	FOXH1	forkhead box H1	3402	0.07
chr20_25058615_25058863	0.18	VSX1	visual system homeobox 1	4028	0.24
chr20_30659418_30659569	0.18	HCK	hemopoietic cell kinase	19429	0.11
chr17_18893756_18893907	0.18	FAM83G	family with sequence similarity 83, member G	12630	0.12
chr16_30472246_30472632	0.18	ENSG00000202476	.	7021	0.06
chr3_127308866_127309017	0.18	TPRA1	transmembrane protein, adipocyte asscociated 1	601	0.74
chr6_160238565_160238716	0.17	PNLDC1	poly(A)-specific ribonuclease (PARN)-like domain containing 1	17334	0.12
chr15_50474903_50475054	0.17	ATP8B4	ATPase, class I, type 8B, member 4	36	0.91
chr17_8090528_8090815	0.17	ENSG00000266638	.	178	0.86
chr14_74079365_74079641	0.17	ACOT6	acyl-CoA thioesterase 6	1854	0.22
chr20_61050006_61050157	0.17	GATA5	GATA binding protein 5	945	0.53
chr18_78007225_78007376	0.17	PARD6G	par-6 family cell polarity regulator gamma	1871	0.44
chr17_7592540_7592816	0.17	WRAP53	WD repeat containing, antisense to TP53	883	0.32
chr1_236064109_236064608	0.17	ENSG00000206803	.	14357	0.16
chr1_28052713_28052864	0.17	FAM76A	family with sequence similarity 76, member A	220	0.9
chr2_28767791_28768074	0.17	PLB1	phospholipase B1	3435	0.31
chr17_79067593_79067744	0.17	BAIAP2	BAI1-associated protein 2	3711	0.14
chr9_136023976_136024127	0.17	RALGDS	ral guanine nucleotide dissociation stimulator	670	0.63
chr22_50721428_50721579	0.16	PLXNB2	plexin B2	194	0.87
chr6_603340_603491	0.16	HUS1B	HUS1 checkpoint homolog b (S. pombe)	53548	0.15
chr7_1513917_1514083	0.16	INTS1	integrator complex subunit 1	1214	0.4
chr3_182101523_182101674	0.16	RP11-225N10.1		409584	0.01
chr5_169172919_169173070	0.16	DOCK2	dedicator of cytokinesis 2	13727	0.24
chr6_26087576_26087727	0.16	HFE	hemochromatosis	16	0.94
chr2_240168955_240169228	0.16	HDAC4	histone deacetylase 4	56339	0.1
chr2_99954133_99954284	0.15	EIF5B	eukaryotic translation initiation factor 5B	392	0.77
chr15_63664697_63665270	0.15	CA12	carbonic anhydrase XII	9051	0.26
chr8_122558149_122558407	0.15	ENSG00000263525	.	3043	0.37
chr3_10057184_10057732	0.15	EMC3	ER membrane protein complex subunit 3	4658	0.11
chr8_131011679_131011830	0.15	ENSG00000253043	.	5093	0.19
chr10_134402672_134402855	0.15	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	18667	0.23
chr16_2391058_2391263	0.15	ABCA3	ATP-binding cassette, sub-family A (ABC1), member 3	413	0.73
chr19_19539011_19539215	0.15	GATAD2A	GATA zinc finger domain containing 2A	777	0.55
chr16_1584078_1584229	0.15	TMEM204	transmembrane protein 204	579	0.41
chr10_88975874_88976033	0.15	NUTM2A	NUT family member 2A	9252	0.21
chr3_30398539_30398690	0.15	ENSG00000199927	.	52587	0.18
chr7_2979039_2979190	0.15	AC004906.3		4555	0.23
chr22_47170259_47170421	0.14	TBC1D22A	TBC1 domain family, member 22A	516	0.79
chr2_208675165_208675316	0.14	FZD5	frizzled family receptor 5	40953	0.12
chr19_47951061_47951212	0.14	SLC8A2	solute carrier family 8 (sodium/calcium exchanger), member 2	23984	0.12
chr1_3514916_3515113	0.14	MEGF6	multiple EGF-like-domains 6	13045	0.13
chr11_2223807_2223958	0.14	ENSG00000265258	.	29589	0.1
chr1_247336437_247336716	0.14	ZNF124	zinc finger protein 124	1258	0.39
chr16_67424084_67424235	0.14	ENSG00000239194	.	594	0.54
chr9_132250210_132250368	0.14	ENSG00000264298	.	9454	0.22
chr1_234614717_234614988	0.14	TARBP1	TAR (HIV-1) RNA binding protein 1	3	0.98
chr6_85483668_85483897	0.14	TBX18	T-box 18	9545	0.3
chr17_39656063_39656224	0.14	AC019349.5		1092	0.28
chr5_178016736_178016887	0.14	COL23A1	collagen, type XXIII, alpha 1	745	0.68
chr18_22930035_22930188	0.14	ZNF521	zinc finger protein 521	1046	0.66
chr17_26878964_26879115	0.14	UNC119	unc-119 homolog (C. elegans)	219	0.84
chr17_80175257_80175581	0.14	RP13-516M14.2		3316	0.13
chr20_62339731_62339882	0.13	ZGPAT	zinc finger, CCCH-type with G patch domain	364	0.48
chr1_155164076_155164322	0.13	ENSG00000271748	.	769	0.29
chr14_62000458_62000638	0.13	RP11-47I22.4		4702	0.22
chr15_75931759_75932122	0.13	IMP3	IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)	612	0.55
chr17_78801730_78801881	0.13	RP11-28G8.1		22373	0.2
chr11_119455747_119455948	0.13	RP11-196E1.3		23288	0.19
chr1_41964550_41964701	0.13	EDN2	endothelin 2	14283	0.2
chr10_47668348_47668587	0.13	ANTXRL	anthrax toxin receptor-like	10218	0.2
chr17_39656944_39657095	0.13	AC019349.5		216	0.84
chr8_49427273_49427424	0.13	RP11-770E5.1		36779	0.23
chr9_124308087_124308238	0.13	ENSG00000252940	.	6007	0.19
chr10_73731046_73731197	0.13	CHST3	carbohydrate (chondroitin 6) sulfotransferase 3	6998	0.26
chr20_23064521_23064672	0.13	CD93	CD93 molecule	2381	0.27
chr17_8533868_8534019	0.13	MYH10	myosin, heavy chain 10, non-muscle	92	0.98
chrX_130925857_130926008	0.13	ENSG00000200587	.	147052	0.04
chr2_109745417_109745568	0.13	SH3RF3	SH3 domain containing ring finger 3	312	0.92
chr3_53184032_53184571	0.13	PRKCD	protein kinase C, delta	5724	0.19
chr11_45001370_45001623	0.13	TP53I11	tumor protein p53 inducible protein 11	28888	0.22
chr12_25055485_25055776	0.12	BCAT1	branched chain amino-acid transaminase 1, cytosolic	379	0.48
chr2_26990361_26990533	0.12	SLC35F6	solute carrier family 35, member F6	3290	0.23
chr3_57935477_57935765	0.12	SLMAP	sarcolemma associated protein	32929	0.19
chr1_6355119_6355270	0.12	GPR153	G protein-coupled receptor 153	34159	0.1
chr19_8553452_8553653	0.12	HNRNPM	heterogeneous nuclear ribonucleoprotein M	2510	0.18
chr11_2187663_2187887	0.12	TH	tyrosine hydroxylase	1561	0.23
chr2_60579152_60579304	0.12	ENSG00000200807	.	32512	0.19
chr13_114525150_114525301	0.12	GAS6-AS1	GAS6 antisense RNA 1	6622	0.22
chr1_150039467_150039618	0.12	VPS45	vacuolar protein sorting 45 homolog (S. cerevisiae)	103	0.96
chr19_41349423_41349599	0.12	CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	6841	0.14
chr4_103609194_103609711	0.12	MANBA	mannosidase, beta A, lysosomal	72638	0.1
chr16_48570088_48570239	0.12	RP11-44I10.3		23409	0.17
chr8_101322815_101323530	0.12	RNF19A	ring finger protein 19A, RBR E3 ubiquitin protein ligase	617	0.78
chr6_157977560_157977711	0.12	ENSG00000266617	.	27471	0.21
chrX_49030494_49030789	0.12	PLP2	proteolipid protein 2 (colonic epithelium-enriched)	2368	0.13
chr8_11565915_11566066	0.12	GATA4	GATA binding protein 4	248	0.92
chr19_5827352_5827630	0.12	NRTN	neurturin	3678	0.1
chr15_83875350_83875501	0.12	HDGFRP3	Hepatoma-derived growth factor-related protein 3	1345	0.43
chr16_1968651_1968802	0.12	HS3ST6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	285	0.74
chr19_56015578_56015806	0.12	SSC5D	scavenger receptor cysteine rich domain containing (5 domains)	10434	0.08
chr14_34529991_34530222	0.12	EGLN3-AS1	EGLN3 antisense RNA 1	20803	0.25
chr3_145879067_145879218	0.12	PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	188	0.96
chr2_105489675_105489826	0.12	LINC01159	long intergenic non-protein coding RNA 1159	697	0.61
chr16_57037843_57038089	0.12	NLRC5	NLR family, CARD domain containing 5	201	0.92
chr8_130709802_130710031	0.11	GSDMC	gasdermin C	89218	0.08
chr22_50122646_50122797	0.11	ENSG00000223142	.	9604	0.22
chr1_224032718_224032869	0.11	TP53BP2	tumor protein p53 binding protein, 2	839	0.72
chrX_107019456_107019640	0.11	TSC22D3	TSC22 domain family, member 3	60	0.96
chr3_197476743_197476894	0.11	FYTTD1	forty-two-three domain containing 1	197	0.56
chr3_124880542_124880693	0.11	ENSG00000264986	.	10221	0.19
chr9_135045081_135045232	0.11	NTNG2	netrin G2	7822	0.25
chr19_10859737_10859950	0.11	DNM2	dynamin 2	30606	0.09
chr22_26565763_26565931	0.11	SEZ6L	seizure related 6 homolog (mouse)-like	223	0.94
chr1_154474981_154475132	0.11	TDRD10	tudor domain containing 10	361	0.54
chr7_148762266_148762471	0.11	ZNF786	zinc finger protein 786	25429	0.11
chr2_20647190_20647341	0.11	RHOB	ras homolog family member B	430	0.84
chr8_29420044_29420195	0.11	RP4-676L2.1		209432	0.02
chr17_75369794_75369945	0.11	SEPT9	septin 9	450	0.8
chr16_2521832_2521983	0.11	NTN3	netrin 3	407	0.61
chr11_74952604_74952755	0.11	TPBGL	trophoblast glycoprotein-like	729	0.6
chr3_143321015_143321295	0.11	SLC9A9-AS2	SLC9A9 antisense RNA 2	220975	0.02
chr9_20621148_20621336	0.11	MLLT3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	630	0.75
chr20_39765712_39765863	0.11	PLCG1	phospholipase C, gamma 1	90	0.94
chr3_193689544_193689695	0.11	RP11-135A1.2		159371	0.04
chr11_33279873_33280030	0.11	HIPK3	homeodomain interacting protein kinase 3	74	0.98
chr14_75389794_75389999	0.11	RPS6KL1	ribosomal protein S6 kinase-like 1	58	0.97
chr3_14444833_14444984	0.11	SLC6A6	solute carrier family 6 (neurotransmitter transporter), member 6	788	0.69
chr17_38187925_38188076	0.11	ENSG00000238793	.	4102	0.13
chr3_169041201_169041352	0.11	MECOM	MDS1 and EVI1 complex locus	54250	0.16
chr7_2019784_2019935	0.11	MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	567	0.84
chr17_76137750_76137971	0.11	C17orf99	chromosome 17 open reading frame 99	4574	0.12
chr17_17631785_17632060	0.11	RAI1-AS1	RAI1 antisense RNA 1	42213	0.1
chr1_9942861_9943012	0.11	CTNNBIP1	catenin, beta interacting protein 1	4702	0.17
chr9_137276901_137277082	0.11	ENSG00000263897	.	5734	0.25
chr2_232478276_232478563	0.11	C2orf57	chromosome 2 open reading frame 57	20844	0.15
chr16_79046532_79046733	0.11	RP11-319G9.5		18390	0.19
chr7_105710732_105710883	0.11	SYPL1	synaptophysin-like 1	27501	0.22
chr12_124985454_124985605	0.11	NCOR2	nuclear receptor corepressor 2	5731	0.33
chr6_1703338_1703561	0.11	FOXC1	forkhead box C1	92768	0.09
chr7_28076620_28076771	0.11	JAZF1	JAZF zinc finger 1	16277	0.26
chr9_135116163_135116314	0.11	ENSG00000221105	.	25976	0.2
chr10_80831884_80832062	0.11	ZMIZ1	zinc finger, MIZ-type containing 1	3181	0.3
chr6_158401711_158402013	0.11	SYNJ2	synaptojanin 2	1026	0.54
chr11_1851555_1851968	0.11	SYT8	synaptotagmin VIII	922	0.39
chr15_99211968_99212377	0.11	IGF1R	insulin-like growth factor 1 receptor	19899	0.21
chr2_202098532_202098973	0.11	CASP8	caspase 8, apoptosis-related cysteine peptidase	523	0.78
chr13_28540704_28540855	0.10	CDX2	caudal type homeobox 2	4497	0.16
chr16_25704360_25704511	0.10	HS3ST4	heparan sulfate (glucosamine) 3-O-sulfotransferase 4	1088	0.69
chr16_11391591_11391742	0.10	ENSG00000238409	.	4599	0.09
chr16_81542300_81542584	0.10	CMIP	c-Maf inducing protein	13488	0.27
chr8_142216214_142216365	0.10	DENND3	DENN/MADD domain containing 3	13859	0.16
chr11_76381975_76382126	0.10	LRRC32	leucine rich repeat containing 32	259	0.91
chr21_38593352_38593525	0.10	ENSG00000263969	.	5532	0.17
chr14_77416963_77417114	0.10	ENSG00000266553	.	17070	0.2
chr15_50549728_50549936	0.10	HDC	histidine decarboxylase	5794	0.16
chr16_770731_770926	0.10	FAM173A	family with sequence similarity 173, member A	147	0.85
chr7_83690336_83690549	0.10	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	133775	0.05
chr16_66519004_66519282	0.10	AC132186.1	CDNA FLJ27243 fis, clone SYN08134; Uncharacterized protein	604	0.62
chr6_158993431_158993582	0.10	TMEM181	transmembrane protein 181	36038	0.15
chr18_77267409_77267811	0.10	AC018445.1	Uncharacterized protein	8447	0.28
chr21_40386580_40386797	0.10	ENSG00000272015	.	119979	0.05
chr22_37414309_37414730	0.10	TST	thiosulfate sulfurtransferase (rhodanese)	989	0.3
chr2_218354093_218354244	0.10	ENSG00000251982	.	237889	0.02
chr14_93526704_93527068	0.10	ITPK1	inositol-tetrakisphosphate 1-kinase	5817	0.21
chr1_44680378_44680549	0.10	DMAP1	DNA methyltransferase 1 associated protein 1	950	0.55
chr9_100396157_100396308	0.10	TSTD2	thiosulfate sulfurtransferase (rhodanese)-like domain containing 2	270	0.53
chr4_965118_965269	0.10	DGKQ	diacylglycerol kinase, theta 110kDa	1917	0.24

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.2	GO:0060575	intestinal epithelial cell differentiation(GO:0060575)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.1	GO:0046628	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.1	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.1	GO:0042416	dopamine biosynthetic process(GO:0042416)
0.0	0.0	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.0	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.1	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0	0.1	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.2	GO:0034405	response to fluid shear stress(GO:0034405)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0045905	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.1	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.0	GO:0072338	allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.1	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.2	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.0	GO:0032352	positive regulation of hormone metabolic process(GO:0032352) positive regulation of hormone biosynthetic process(GO:0046886)
0.0	0.0	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.0	GO:0032203	telomere formation via telomerase(GO:0032203)
0.0	0.1	GO:0014721	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.0	GO:0032823	regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.1	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.0	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.1	GO:0032354	response to follicle-stimulating hormone(GO:0032354)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.0	GO:0048752	semicircular canal morphogenesis(GO:0048752) semicircular canal development(GO:0060872)
0.0	0.0	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.0	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.0	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0070265	necrotic cell death(GO:0070265)
0.0	0.0	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.0	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.1	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.0	GO:0051594	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	GO:0042599	lamellar body(GO:0042599)
0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.4	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	GO:0032432	actin filament bundle(GO:0032432)
0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.1	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1	0.2	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.3	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.2	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.1	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0001012	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.1	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.1	GO:0031014	troponin T binding(GO:0031014)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.0	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.0	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.0	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.0	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.0	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0046870	cadmium ion binding(GO:0046870)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.0	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.0	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.0	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0033613	activating transcription factor binding(GO:0033613)
0.0	0.0	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.0	GO:0034617	tetrahydrobiopterin binding(GO:0034617)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.0	GO:0030151	molybdenum ion binding(GO:0030151)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.2	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.3	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.1	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide