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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for HIF1A

Z-value: 0.76

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Transcription factors associated with HIF1A

Gene Symbol Gene ID Gene Info
HIF1A
ENSG00000100644.12 hypoxia inducible factor 1 subunit alpha

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr14_62183724_62184123HIF1A195830.216505-0.862.6e-03Click!
chr14_62176844_62177091HIF1A126270.234024-0.853.3e-03Click!
chr14_62169999_62170295HIF1A58070.260531-0.827.1e-03Click!
chr14_62182699_62182850HIF1A184340.219529-0.801.0e-02Click!
chr14_62173062_62173362HIF1A88720.244524-0.761.7e-02Click!

Activity of the HIF1A motif across conditions

Conditions sorted by the z-value of the HIF1A motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr18_10726488_10726639 0.47 PIEZO2
 piezo-type mechanosensitive ion channel component 2
 21935
 0.2
chr2_74648839_74648990 0.43 WDR54
 WD repeat domain 54
 57
 0.67
chr8_61973816_61973967 0.40 CLVS1
 clavesin 1
 4174
 0.36
chr4_82136461_82136814 0.38 PRKG2
 protein kinase, cGMP-dependent, type II
 419
 0.89
chr9_93956113_93956298 0.35 AUH
 AU RNA binding protein/enoyl-CoA hydratase
 167972
 0.04
chr9_138999867_139000258 0.34 C9orf69
 chromosome 9 open reading frame 69
 10058
 0.19
chr11_133920937_133921088 0.32 JAM3
 junctional adhesion molecule 3
 17808
 0.22
chr19_42391298_42391529 0.31 ARHGEF1
 Rho guanine nucleotide exchange factor (GEF) 1
 2898
 0.16
chr18_43913575_43913778 0.30 RNF165
 ring finger protein 165
 255
 0.95
chr5_11384831_11385016 0.28 CTNND2
 catenin (cadherin-associated protein), delta 2
 204000
 0.03
chr1_65533556_65533707 0.27 ENSG00000199135
 .
 9440
 0.19
chrX_77359735_77359886 0.27 PGK1
 phosphoglycerate kinase 1
 58
 0.98
chr16_68022948_68023099 0.27 DUS2
 dihydrouridine synthase 2
 1348
 0.22
chr10_81002057_81002208 0.26 ZMIZ1
 zinc finger, MIZ-type containing 1
 63843
 0.13
chr15_90606260_90606411 0.26 ZNF710
 zinc finger protein 710
 4911
 0.16
chr18_51795667_51795818 0.24 POLI
 polymerase (DNA directed) iota
 32
 0.98
chr7_44303433_44303584 0.24 CAMK2B
 calcium/calmodulin-dependent protein kinase II beta
 21603
 0.17
chr19_41328238_41328415 0.23 EGLN2
 egl-9 family hypoxia-inducible factor 2
 15178
 0.12
chr8_72755880_72756041 0.23 RP11-383H13.1
 Protein LOC100132891; cDNA FLJ53548
 164
 0.88
chr5_43397167_43397386 0.22 CCL28
 chemokine (C-C motif) ligand 28
 90
 0.97
chr4_187112479_187112630 0.22 AC110771.1
 Uncharacterized protein
 72
 0.56
chr3_100240423_100240574 0.22 TMEM45A
 transmembrane protein 45A
 28994
 0.2
chr3_133576348_133576499 0.21 RAB6B
 RAB6B, member RAS oncogene family
 37140
 0.15
chr13_27936429_27936610 0.21 ENSG00000252247
 .
 18636
 0.15
chr9_140051094_140051245 0.21 ENSG00000263697
 .
 12553
 0.06
chr16_85590036_85590187 0.20 GSE1
 Gse1 coiled-coil protein
 54904
 0.13
chr21_39850220_39850518 0.20 ERG
 v-ets avian erythroblastosis virus E26 oncogene homolog
 19976
 0.28
chr16_3766966_3767153 0.20 TRAP1
 TNF receptor-associated protein 1
 455
 0.82
chr7_95100446_95100597 0.20 ASB4
 ankyrin repeat and SOCS box containing 4
 14692
 0.17
chr2_232505608_232505920 0.20 ENSG00000239202
 .
 5220
 0.2
chr6_139695018_139695224 0.20 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 229
 0.96
chr8_126614315_126614538 0.20 ENSG00000266452
 .
 157619
 0.04
chr14_34407515_34407805 0.20 EGLN3
 egl-9 family hypoxia-inducible factor 3
 12372
 0.25
chr19_2288228_2288485 0.20 LINGO3
 leucine rich repeat and Ig domain containing 3
 3667
 0.1
chr17_75317312_75317463 0.20 SEPT9
 septin 9
 992
 0.6
chr5_10746814_10746997 0.20 CTD-2154B17.4
14272
 0.22
chr1_36040729_36040916 0.20 RP4-728D4.2
1474
 0.29
chr17_38511467_38511733 0.20 CTD-2267D19.3
 Uncharacterized protein
 5307
 0.11
chr8_130722541_130722692 0.19 GSDMC
 gasdermin C
 76518
 0.1
chr19_55670752_55670903 0.19 CTD-2587H24.5
520
 0.5
chr14_64804805_64805119 0.19 ESR2
 estrogen receptor 2 (ER beta)
 132
 0.76
chr9_134901891_134902042 0.18 MED27
 mediator complex subunit 27
 53287
 0.16
chr4_2044269_2044420 0.18 C4orf48
 chromosome 4 open reading frame 48
 567
 0.49
chr8_145698238_145698394 0.18 FOXH1
 forkhead box H1
 3402
 0.07
chr20_25058615_25058863 0.18 VSX1
 visual system homeobox 1
 4028
 0.24
chr20_30659418_30659569 0.18 HCK
 hemopoietic cell kinase
 19429
 0.11
chr17_18893756_18893907 0.18 FAM83G
 family with sequence similarity 83, member G
 12630
 0.12
chr16_30472246_30472632 0.18 ENSG00000202476
 .
 7021
 0.06
chr3_127308866_127309017 0.18 TPRA1
 transmembrane protein, adipocyte asscociated 1
 601
 0.74
chr6_160238565_160238716 0.17 PNLDC1
 poly(A)-specific ribonuclease (PARN)-like domain containing 1
 17334
 0.12
chr15_50474903_50475054 0.17 ATP8B4
 ATPase, class I, type 8B, member 4
 36
 0.91
chr17_8090528_8090815 0.17 ENSG00000266638
 .
 178
 0.86
chr14_74079365_74079641 0.17 ACOT6
 acyl-CoA thioesterase 6
 1854
 0.22
chr20_61050006_61050157 0.17 GATA5
 GATA binding protein 5
 945
 0.53
chr18_78007225_78007376 0.17 PARD6G
 par-6 family cell polarity regulator gamma
 1871
 0.44
chr17_7592540_7592816 0.17 WRAP53
 WD repeat containing, antisense to TP53
 883
 0.32
chr1_236064109_236064608 0.17 ENSG00000206803
 .
 14357
 0.16
chr1_28052713_28052864 0.17 FAM76A
 family with sequence similarity 76, member A
 220
 0.9
chr2_28767791_28768074 0.17 PLB1
 phospholipase B1
 3435
 0.31
chr17_79067593_79067744 0.17 BAIAP2
 BAI1-associated protein 2
 3711
 0.14
chr9_136023976_136024127 0.17 RALGDS
 ral guanine nucleotide dissociation stimulator
 670
 0.63
chr22_50721428_50721579 0.16 PLXNB2
 plexin B2
 194
 0.87
chr6_603340_603491 0.16 HUS1B
 HUS1 checkpoint homolog b (S. pombe)
 53548
 0.15
chr7_1513917_1514083 0.16 INTS1
 integrator complex subunit 1
 1214
 0.4
chr3_182101523_182101674 0.16 RP11-225N10.1
409584
 0.01
chr5_169172919_169173070 0.16 DOCK2
 dedicator of cytokinesis 2
 13727
 0.24
chr6_26087576_26087727 0.16 HFE
 hemochromatosis
 16
 0.94
chr2_240168955_240169228 0.16 HDAC4
 histone deacetylase 4
 56339
 0.1
chr2_99954133_99954284 0.15 EIF5B
 eukaryotic translation initiation factor 5B
 392
 0.77
chr15_63664697_63665270 0.15 CA12
 carbonic anhydrase XII
 9051
 0.26
chr8_122558149_122558407 0.15 ENSG00000263525
 .
 3043
 0.37
chr3_10057184_10057732 0.15 EMC3
 ER membrane protein complex subunit 3
 4658
 0.11
chr8_131011679_131011830 0.15 ENSG00000253043
 .
 5093
 0.19
chr10_134402672_134402855 0.15 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 18667
 0.23
chr16_2391058_2391263 0.15 ABCA3
 ATP-binding cassette, sub-family A (ABC1), member 3
 413
 0.73
chr19_19539011_19539215 0.15 GATAD2A
 GATA zinc finger domain containing 2A
 777
 0.55
chr16_1584078_1584229 0.15 TMEM204
 transmembrane protein 204
 579
 0.41
chr10_88975874_88976033 0.15 NUTM2A
 NUT family member 2A
 9252
 0.21
chr3_30398539_30398690 0.15 ENSG00000199927
 .
 52587
 0.18
chr7_2979039_2979190 0.15 AC004906.3
4555
 0.23
chr22_47170259_47170421 0.14 TBC1D22A
 TBC1 domain family, member 22A
 516
 0.79
chr2_208675165_208675316 0.14 FZD5
 frizzled family receptor 5
 40953
 0.12
chr19_47951061_47951212 0.14 SLC8A2
 solute carrier family 8 (sodium/calcium exchanger), member 2
 23984
 0.12
chr1_3514916_3515113 0.14 MEGF6
 multiple EGF-like-domains 6
 13045
 0.13
chr11_2223807_2223958 0.14 ENSG00000265258
 .
 29589
 0.1
chr1_247336437_247336716 0.14 ZNF124
 zinc finger protein 124
 1258
 0.39
chr16_67424084_67424235 0.14 ENSG00000239194
 .
 594
 0.54
chr9_132250210_132250368 0.14 ENSG00000264298
 .
 9454
 0.22
chr1_234614717_234614988 0.14 TARBP1
 TAR (HIV-1) RNA binding protein 1
 3
 0.98
chr6_85483668_85483897 0.14 TBX18
 T-box 18
 9545
 0.3
chr17_39656063_39656224 0.14 AC019349.5
1092
 0.28
chr5_178016736_178016887 0.14 COL23A1
 collagen, type XXIII, alpha 1
 745
 0.68
chr18_22930035_22930188 0.14 ZNF521
 zinc finger protein 521
 1046
 0.66
chr17_26878964_26879115 0.14 UNC119
 unc-119 homolog (C. elegans)
 219
 0.84
chr17_80175257_80175581 0.14 RP13-516M14.2
3316
 0.13
chr20_62339731_62339882 0.13 ZGPAT
 zinc finger, CCCH-type with G patch domain
 364
 0.48
chr1_155164076_155164322 0.13 ENSG00000271748
 .
 769
 0.29
chr14_62000458_62000638 0.13 RP11-47I22.4
4702
 0.22
chr15_75931759_75932122 0.13 IMP3
 IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
 612
 0.55
chr17_78801730_78801881 0.13 RP11-28G8.1
22373
 0.2
chr11_119455747_119455948 0.13 RP11-196E1.3
23288
 0.19
chr1_41964550_41964701 0.13 EDN2
 endothelin 2
 14283
 0.2
chr10_47668348_47668587 0.13 ANTXRL
 anthrax toxin receptor-like
 10218
 0.2
chr17_39656944_39657095 0.13 AC019349.5
216
 0.84
chr8_49427273_49427424 0.13 RP11-770E5.1
36779
 0.23
chr9_124308087_124308238 0.13 ENSG00000252940
 .
 6007
 0.19
chr10_73731046_73731197 0.13 CHST3
 carbohydrate (chondroitin 6) sulfotransferase 3
 6998
 0.26
chr20_23064521_23064672 0.13 CD93
 CD93 molecule
 2381
 0.27
chr17_8533868_8534019 0.13 MYH10
 myosin, heavy chain 10, non-muscle
 92
 0.98
chrX_130925857_130926008 0.13 ENSG00000200587
 .
 147052
 0.04
chr2_109745417_109745568 0.13 SH3RF3
 SH3 domain containing ring finger 3
 312
 0.92
chr3_53184032_53184571 0.13 PRKCD
 protein kinase C, delta
 5724
 0.19
chr11_45001370_45001623 0.13 TP53I11
 tumor protein p53 inducible protein 11
 28888
 0.22
chr12_25055485_25055776 0.12 BCAT1
 branched chain amino-acid transaminase 1, cytosolic
 379
 0.48
chr2_26990361_26990533 0.12 SLC35F6
 solute carrier family 35, member F6
 3290
 0.23
chr3_57935477_57935765 0.12 SLMAP
 sarcolemma associated protein
 32929
 0.19
chr1_6355119_6355270 0.12 GPR153
 G protein-coupled receptor 153
 34159
 0.1
chr19_8553452_8553653 0.12 HNRNPM
 heterogeneous nuclear ribonucleoprotein M
 2510
 0.18
chr11_2187663_2187887 0.12 TH
 tyrosine hydroxylase
 1561
 0.23
chr2_60579152_60579304 0.12 ENSG00000200807
 .
 32512
 0.19
chr13_114525150_114525301 0.12 GAS6-AS1
 GAS6 antisense RNA 1
 6622
 0.22
chr1_150039467_150039618 0.12 VPS45
 vacuolar protein sorting 45 homolog (S. cerevisiae)
 103
 0.96
chr19_41349423_41349599 0.12 CYP2A6
 cytochrome P450, family 2, subfamily A, polypeptide 6
 6841
 0.14
chr4_103609194_103609711 0.12 MANBA
 mannosidase, beta A, lysosomal
 72638
 0.1
chr16_48570088_48570239 0.12 RP11-44I10.3
23409
 0.17
chr8_101322815_101323530 0.12 RNF19A
 ring finger protein 19A, RBR E3 ubiquitin protein ligase
 617
 0.78
chr6_157977560_157977711 0.12 ENSG00000266617
 .
 27471
 0.21
chrX_49030494_49030789 0.12 PLP2
 proteolipid protein 2 (colonic epithelium-enriched)
 2368
 0.13
chr8_11565915_11566066 0.12 GATA4
 GATA binding protein 4
 248
 0.92
chr19_5827352_5827630 0.12 NRTN
 neurturin
 3678
 0.1
chr15_83875350_83875501 0.12 HDGFRP3
 Hepatoma-derived growth factor-related protein 3
 1345
 0.43
chr16_1968651_1968802 0.12 HS3ST6
 heparan sulfate (glucosamine) 3-O-sulfotransferase 6
 285
 0.74
chr19_56015578_56015806 0.12 SSC5D
 scavenger receptor cysteine rich domain containing (5 domains)
 10434
 0.08
chr14_34529991_34530222 0.12 EGLN3-AS1
 EGLN3 antisense RNA 1
 20803
 0.25
chr3_145879067_145879218 0.12 PLOD2
 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
 188
 0.96
chr2_105489675_105489826 0.12 LINC01159
 long intergenic non-protein coding RNA 1159
 697
 0.61
chr16_57037843_57038089 0.12 NLRC5
 NLR family, CARD domain containing 5
 201
 0.92
chr8_130709802_130710031 0.11 GSDMC
 gasdermin C
 89218
 0.08
chr22_50122646_50122797 0.11 ENSG00000223142
 .
 9604
 0.22
chr1_224032718_224032869 0.11 TP53BP2
 tumor protein p53 binding protein, 2
 839
 0.72
chrX_107019456_107019640 0.11 TSC22D3
 TSC22 domain family, member 3
 60
 0.96
chr3_197476743_197476894 0.11 FYTTD1
 forty-two-three domain containing 1
 197
 0.56
chr3_124880542_124880693 0.11 ENSG00000264986
 .
 10221
 0.19
chr9_135045081_135045232 0.11 NTNG2
 netrin G2
 7822
 0.25
chr19_10859737_10859950 0.11 DNM2
 dynamin 2
 30606
 0.09
chr22_26565763_26565931 0.11 SEZ6L
 seizure related 6 homolog (mouse)-like
 223
 0.94
chr1_154474981_154475132 0.11 TDRD10
 tudor domain containing 10
 361
 0.54
chr7_148762266_148762471 0.11 ZNF786
 zinc finger protein 786
 25429
 0.11
chr2_20647190_20647341 0.11 RHOB
 ras homolog family member B
 430
 0.84
chr8_29420044_29420195 0.11 RP4-676L2.1
209432
 0.02
chr17_75369794_75369945 0.11 SEPT9
 septin 9
 450
 0.8
chr16_2521832_2521983 0.11 NTN3
 netrin 3
 407
 0.61
chr11_74952604_74952755 0.11 TPBGL
 trophoblast glycoprotein-like
 729
 0.6
chr3_143321015_143321295 0.11 SLC9A9-AS2
 SLC9A9 antisense RNA 2
 220975
 0.02
chr9_20621148_20621336 0.11 MLLT3
 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
 630
 0.75
chr20_39765712_39765863 0.11 PLCG1
 phospholipase C, gamma 1
 90
 0.94
chr3_193689544_193689695 0.11 RP11-135A1.2
159371
 0.04
chr11_33279873_33280030 0.11 HIPK3
 homeodomain interacting protein kinase 3
 74
 0.98
chr14_75389794_75389999 0.11 RPS6KL1
 ribosomal protein S6 kinase-like 1
 58
 0.97
chr3_14444833_14444984 0.11 SLC6A6
 solute carrier family 6 (neurotransmitter transporter), member 6
 788
 0.69
chr17_38187925_38188076 0.11 ENSG00000238793
 .
 4102
 0.13
chr3_169041201_169041352 0.11 MECOM
 MDS1 and EVI1 complex locus
 54250
 0.16
chr7_2019784_2019935 0.11 MAD1L1
 MAD1 mitotic arrest deficient-like 1 (yeast)
 567
 0.84
chr17_76137750_76137971 0.11 C17orf99
 chromosome 17 open reading frame 99
 4574
 0.12
chr17_17631785_17632060 0.11 RAI1-AS1
 RAI1 antisense RNA 1
 42213
 0.1
chr1_9942861_9943012 0.11 CTNNBIP1
 catenin, beta interacting protein 1
 4702
 0.17
chr9_137276901_137277082 0.11 ENSG00000263897
 .
 5734
 0.25
chr2_232478276_232478563 0.11 C2orf57
 chromosome 2 open reading frame 57
 20844
 0.15
chr16_79046532_79046733 0.11 RP11-319G9.5
18390
 0.19
chr7_105710732_105710883 0.11 SYPL1
 synaptophysin-like 1
 27501
 0.22
chr12_124985454_124985605 0.11 NCOR2
 nuclear receptor corepressor 2
 5731
 0.33
chr6_1703338_1703561 0.11 FOXC1
 forkhead box C1
 92768
 0.09
chr7_28076620_28076771 0.11 JAZF1
 JAZF zinc finger 1
 16277
 0.26
chr9_135116163_135116314 0.11 ENSG00000221105
 .
 25976
 0.2
chr10_80831884_80832062 0.11 ZMIZ1
 zinc finger, MIZ-type containing 1
 3181
 0.3
chr6_158401711_158402013 0.11 SYNJ2
 synaptojanin 2
 1026
 0.54
chr11_1851555_1851968 0.11 SYT8
 synaptotagmin VIII
 922
 0.39
chr15_99211968_99212377 0.11 IGF1R
 insulin-like growth factor 1 receptor
 19899
 0.21
chr2_202098532_202098973 0.11 CASP8
 caspase 8, apoptosis-related cysteine peptidase
 523
 0.78
chr13_28540704_28540855 0.10 CDX2
 caudal type homeobox 2
 4497
 0.16
chr16_25704360_25704511 0.10 HS3ST4
 heparan sulfate (glucosamine) 3-O-sulfotransferase 4
 1088
 0.69
chr16_11391591_11391742 0.10 ENSG00000238409
 .
 4599
 0.09
chr16_81542300_81542584 0.10 CMIP
 c-Maf inducing protein
 13488
 0.27
chr8_142216214_142216365 0.10 DENND3
 DENN/MADD domain containing 3
 13859
 0.16
chr11_76381975_76382126 0.10 LRRC32
 leucine rich repeat containing 32
 259
 0.91
chr21_38593352_38593525 0.10 ENSG00000263969
 .
 5532
 0.17
chr14_77416963_77417114 0.10 ENSG00000266553
 .
 17070
 0.2
chr15_50549728_50549936 0.10 HDC
 histidine decarboxylase
 5794
 0.16
chr16_770731_770926 0.10 FAM173A
 family with sequence similarity 173, member A
 147
 0.85
chr7_83690336_83690549 0.10 SEMA3A
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
 133775
 0.05
chr16_66519004_66519282 0.10 AC132186.1
 CDNA FLJ27243 fis, clone SYN08134; Uncharacterized protein
 604
 0.62
chr6_158993431_158993582 0.10 TMEM181
 transmembrane protein 181
 36038
 0.15
chr18_77267409_77267811 0.10 AC018445.1
 Uncharacterized protein
 8447
 0.28
chr21_40386580_40386797 0.10 ENSG00000272015
 .
 119979
 0.05
chr22_37414309_37414730 0.10 TST
 thiosulfate sulfurtransferase (rhodanese)
 989
 0.3
chr2_218354093_218354244 0.10 ENSG00000251982
 .
 237889
 0.02
chr14_93526704_93527068 0.10 ITPK1
 inositol-tetrakisphosphate 1-kinase
 5817
 0.21
chr1_44680378_44680549 0.10 DMAP1
 DNA methyltransferase 1 associated protein 1
 950
 0.55
chr9_100396157_100396308 0.10 TSTD2
 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2
 270
 0.53
chr4_965118_965269 0.10 DGKQ
 diacylglycerol kinase, theta 110kDa
 1917
 0.24

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
0.0 0.2 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.1 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.1 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0036336 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:0006927 obsolete transformed cell apoptotic process(GO:0006927)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0016081 synaptic vesicle docking(GO:0016081)
0.0 0.1 GO:0042416 dopamine biosynthetic process(GO:0042416)
0.0 0.0 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.0 GO:0003078 obsolete regulation of natriuresis(GO:0003078)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.2 GO:0034405 response to fluid shear stress(GO:0034405)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.0 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.0 GO:0072338 allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0 0.1 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.2 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.0 GO:0051451 myoblast migration(GO:0051451)
0.0 0.0 GO:0032352 positive regulation of hormone metabolic process(GO:0032352) positive regulation of hormone biosynthetic process(GO:0046886)
0.0 0.0 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.0 GO:0032203 telomere formation via telomerase(GO:0032203)
0.0 0.1 GO:0014721 voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0 0.0 GO:0032823 regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0 0.1 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.0 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.1 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.0 GO:0048752 semicircular canal morphogenesis(GO:0048752) semicircular canal development(GO:0060872)
0.0 0.0 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.0 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.0 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0070265 necrotic cell death(GO:0070265)
0.0 0.0 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.0 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:0010452 histone H3-K36 methylation(GO:0010452)
0.0 0.0 GO:0051594 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.0 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.0 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.4 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.0 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.0 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.2 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.3 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0001846 opsonin binding(GO:0001846)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.1 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.1 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.0 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.0 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.0 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.0 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.1 GO:0046870 cadmium ion binding(GO:0046870)
0.0 0.0 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.0 GO:0034187 obsolete apolipoprotein E binding(GO:0034187)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.0 GO:0045118 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.0 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.0 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.0 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.0 0.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.0 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.0 GO:0030151 molybdenum ion binding(GO:0030151)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide