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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HLF_TEF

Z-value: 1.57

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Transcription factors associated with HLF_TEF

Gene Symbol	Gene ID	Gene Info
HLF Ensembl NCBI GeneCards UniProt	ENSG00000108924.9	HLF
TEF Ensembl NCBI GeneCards UniProt	ENSG00000167074.10	TEF

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HLF	chr17_53340851_53341002	1447	0.489344	-0.66	5.1e-02	Click!
HLF	chr17_53346103_53346254	1001	0.610099	0.65	5.9e-02	Click!
HLF	chr17_53341084_53341235	1214	0.550873	-0.64	6.2e-02	Click!
HLF	chr17_53245033_53245184	97265	0.078470	0.63	6.9e-02	Click!
HLF	chr17_53315545_53315826	26688	0.212619	0.49	1.8e-01	Click!
TEF	chr22_41763864_41764015	602	0.672897	0.67	5.1e-02	Click!
TEF	chr22_41763473_41763758	278	0.881960	0.61	8.0e-02	Click!
TEF	chr22_41776460_41776636	1385	0.339077	0.55	1.2e-01	Click!
TEF	chr22_41762881_41763188	303	0.867458	0.54	1.4e-01	Click!
TEF	chr22_41809018_41809169	30154	0.108285	0.53	1.4e-01	Click!

Activity of the HLF_TEF motif across conditions

Conditions sorted by the z-value of the HLF_TEF motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr15_71006405_71006665	0.94	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	10921	0.26
chr3_65930585_65930845	0.88	ENSG00000264716	.	3793	0.23
chr12_48163883_48164256	0.75	RAPGEF3	Rap guanine nucleotide exchange factor (GEF) 3	748	0.49
chr11_112027840_112028079	0.73	IL18	interleukin 18 (interferon-gamma-inducing factor)	6838	0.11
chr21_40386888_40387293	0.73	ENSG00000272015	.	120381	0.05
chr8_61896258_61896409	0.72	CLVS1	clavesin 1	73384	0.12
chr6_132513964_132514185	0.70	ENSG00000265669	.	77671	0.11
chr10_22723256_22723780	0.67	RP11-301N24.3		73417	0.1
chr6_5206187_5206422	0.67	ENSG00000264541	.	18726	0.19
chr10_64380892_64381169	0.66	ZNF365	zinc finger protein 365	22503	0.22
chr20_20840342_20840493	0.65	ENSG00000264361	.	121043	0.06
chr4_38822000_38822151	0.63	TLR6	toll-like receptor 6	9085	0.16
chr4_48226743_48226894	0.60	TEC	tec protein tyrosine kinase	45063	0.14
chr10_22284671_22284822	0.60	DNAJC1	DnaJ (Hsp40) homolog, subfamily C, member 1	7582	0.28
chr12_48340702_48340853	0.60	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	3946	0.19
chr4_77303492_77303643	0.60	ENSG00000199857	.	19662	0.14
chr5_145375816_145375967	0.60	SH3RF2	SH3 domain containing ring finger 2	58451	0.13
chr6_14766197_14766507	0.58	ENSG00000206960	.	119586	0.07
chr13_40025518_40025722	0.58	ENSG00000238408	.	4267	0.34
chr3_64034181_64034364	0.58	RP11-129B22.1		19368	0.1
chr12_8043408_8043946	0.57	SLC2A14	solute carrier family 2 (facilitated glucose transporter), member 14	67	0.95
chr8_741942_742093	0.57	ERICH1-AS1	ERICH1 antisense RNA 1	54275	0.14
chr4_140967735_140967886	0.57	RP11-392B6.1		81359	0.1
chr12_65599568_65599732	0.56	LEMD3	LEM domain containing 3	36299	0.17
chr21_43352747_43353275	0.56	C2CD2	C2 calcium-dependent domain containing 2	6212	0.19
chr6_18427728_18428016	0.54	ENSG00000238458	.	25589	0.2
chr12_102250942_102251233	0.53	ENSG00000252863	.	14492	0.12
chr7_133224861_133225123	0.53	EXOC4	exocyst complex component 4	36224	0.24
chr1_214598693_214598940	0.53	PTPN14	protein tyrosine phosphatase, non-receptor type 14	39330	0.19
chr2_219020666_219020817	0.52	CXCR1	chemokine (C-X-C motif) receptor 1	10977	0.14
chr6_41680623_41680774	0.52	TFEB	transcription factor EB	7020	0.13
chr3_124500151_124500305	0.51	ITGB5-AS1	ITGB5 antisense RNA 1	226	0.93
chr3_185466059_185466210	0.51	ENSG00000265470	.	19558	0.2
chr6_11536168_11536406	0.51	TMEM170B	transmembrane protein 170B	1651	0.46
chr13_51939096_51939247	0.50	RP11-24B19.3		1592	0.28
chr5_148365723_148365874	0.50	RP11-44B19.1		15895	0.18
chr10_101288694_101289161	0.50	RP11-129J12.2		1727	0.34
chr14_97292729_97292880	0.49	VRK1	vaccinia related kinase 1	26421	0.26
chr6_135061273_135061513	0.49	ALDH8A1	aldehyde dehydrogenase 8 family, member A1	188906	0.03
chr19_6103075_6103226	0.49	CTB-66B24.1		6183	0.15
chr8_104293348_104293656	0.49	RP11-318M2.2		4628	0.2
chr1_246271383_246271534	0.49	RP11-36N20.1		470	0.86
chr9_70615947_70616098	0.49	AL591479.1	Uncharacterized protein	30567	0.22
chr9_42221074_42221225	0.48	RP11-216M21.7		145943	0.04
chr4_15081864_15082159	0.48	ENSG00000199420	.	13707	0.24
chr5_14544889_14545095	0.48	FAM105A	family with sequence similarity 105, member A	36892	0.19
chr20_10286775_10287859	0.48	ENSG00000211588	.	55561	0.13
chr6_34255201_34255352	0.48	C6orf1	chromosome 6 open reading frame 1	38029	0.15
chr7_92456741_92457310	0.46	CDK6	cyclin-dependent kinase 6	6206	0.23
chr21_45005885_45006040	0.46	HSF2BP	heat shock transcription factor 2 binding protein	72063	0.1
chr18_24326449_24326698	0.45	ENSG00000265369	.	57080	0.13
chr2_216838775_216839059	0.45	MREG	melanoregulin	39429	0.18
chr12_89700664_89700866	0.45	ENSG00000238302	.	24703	0.22
chr16_69775420_69775717	0.45	NOB1	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)	13275	0.1
chr2_26622798_26622949	0.45	DRC1	dynein regulatory complex subunit 1 homolog (Chlamydomonas)	1911	0.36
chr9_45472222_45472373	0.45	AL354718.1	Uncharacterized protein	30755	0.25
chr16_81642292_81642617	0.45	CMIP	c-Maf inducing protein	36509	0.21
chr2_169542981_169543171	0.44	ENSG00000199348	.	80070	0.09
chr19_42947007_42947215	0.43	CXCL17	chemokine (C-X-C motif) ligand 17	89	0.95
chr18_54524017_54524317	0.43	RP11-383D22.1		17034	0.22
chr9_80359497_80359648	0.43	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	78343	0.1
chr3_106466004_106466155	0.43	ENSG00000200361	.	58554	0.17
chr12_121158667_121159015	0.43	ENSG00000265455	.	2155	0.16
chr2_145130083_145130281	0.43	GTDC1	glycosyltransferase-like domain containing 1	40099	0.19
chr11_110349991_110350329	0.43	FDX1	ferredoxin 1	49553	0.18
chr14_75122953_75123104	0.43	AREL1	apoptosis resistant E3 ubiquitin protein ligase 1	19890	0.15
chr1_61719110_61719389	0.42	NFIA	nuclear factor I/A	98873	0.08
chr2_210337378_210337560	0.42	MAP2	microtubule-associated protein 2	48687	0.19
chr7_41516088_41516239	0.42	INHBA-AS1	INHBA antisense RNA 1	217351	0.02
chr12_116436351_116436502	0.42	MED13L	mediator complex subunit 13-like	15186	0.22
chr14_91163076_91163339	0.42	RP11-661G16.2		470	0.81
chr9_3299512_3299760	0.42	RFX3	regulatory factor X, 3 (influences HLA class II expression)	28898	0.26
chr12_71842305_71842456	0.42	TSPAN8	tetraspanin 8	6702	0.24
chr5_88120771_88120961	0.42	MEF2C	myocyte enhancer factor 2C	709	0.77
chr7_149450583_149450734	0.41	ZNF467	zinc finger protein 467	19650	0.19
chr6_116690381_116690532	0.41	DSE	dermatan sulfate epimerase	554	0.78
chr7_92437724_92438202	0.41	CDK6	cyclin-dependent kinase 6	25268	0.19
chr20_49026246_49026397	0.41	ENSG00000244376	.	19699	0.22
chr11_12088585_12089097	0.41	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	26702	0.22
chr6_37008004_37008155	0.41	COX6A1P2	cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2	4528	0.22
chr2_172380569_172381265	0.41	CYBRD1	cytochrome b reductase 1	1328	0.53
chr2_178283039_178283431	0.41	AGPS	alkylglycerone phosphate synthase	25739	0.14
chr3_141248480_141249204	0.41	RASA2-IT1	RASA2 intronic transcript 1 (non-protein coding)	4867	0.27
chr16_71760597_71760829	0.40	PHLPP2	PH domain and leucine rich repeat protein phosphatase 2	2109	0.19
chr4_118955423_118955622	0.40	NDST3	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	22	0.99
chr17_19172351_19172531	0.40	EPN2	epsin 2	11208	0.12
chr10_21311864_21312015	0.40	NEBL	nebulette	47007	0.18
chr6_15463967_15464118	0.40	JARID2	jumonji, AT rich interactive domain 2	62953	0.13
chr15_67094989_67095410	0.39	SMAD6	SMAD family member 6	91164	0.08
chr1_241705552_241705751	0.39	KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	9946	0.22
chr5_148181532_148181683	0.39	ADRB2	adrenoceptor beta 2, surface	24549	0.23
chr3_87849755_87849906	0.39	ENSG00000200703	.	58031	0.15
chr1_207203760_207203911	0.39	C1orf116	chromosome 1 open reading frame 116	2257	0.21
chr1_85154249_85154907	0.39	SSX2IP	synovial sarcoma, X breakpoint 2 interacting protein	1394	0.5
chr5_90677472_90677623	0.39	ARRDC3	arrestin domain containing 3	1629	0.47
chr17_47393434_47393962	0.38	ENSG00000251964	.	9565	0.15
chr5_134702384_134702535	0.38	C5orf66	chromosome 5 open reading frame 66	28830	0.14
chr7_131156247_131156398	0.38	RP11-180C16.1		26131	0.24
chr19_32837185_32838232	0.38	ZNF507	zinc finger protein 507	1083	0.51
chr14_97886866_97887017	0.38	ENSG00000240730	.	109569	0.08
chr12_94997883_94998034	0.38	TMCC3	transmembrane and coiled-coil domain family 3	11879	0.23
chr3_128964455_128964687	0.38	COPG1	coatomer protein complex, subunit gamma 1	3878	0.19
chrX_92616111_92616262	0.38	NAP1L3	nucleosome assembly protein 1-like 3	312381	0.01
chrX_15874840_15875069	0.38	AP1S2	adaptor-related protein complex 1, sigma 2 subunit	1900	0.39
chr12_106673629_106673780	0.37	ENSG00000238609	.	3063	0.23
chr12_70079938_70080089	0.37	BEST3	bestrophin 3	3043	0.26
chr12_66289441_66289878	0.37	RP11-366L20.2	Uncharacterized protein	13712	0.17
chr7_141611302_141611453	0.37	OR9N1P	olfactory receptor, family 9, subfamily N, member 1 pseudogene	114	0.94
chr4_46007135_46007286	0.37	ENSG00000222257	.	10074	0.31
chr8_107978697_107978848	0.37	ABRA	actin-binding Rho activating protein	196299	0.03
chr19_46586098_46586249	0.37	IGFL4	IGF-like family member 4	5821	0.17
chr14_73643539_73643710	0.37	PSEN1	presenilin 1	9087	0.19
chr2_122405151_122406002	0.37	CLASP1	cytoplasmic linker associated protein 1	1476	0.32
chr9_127420744_127420996	0.36	MIR181A2HG	MIR181A2 host gene (non-protein coding)	124	0.96
chr8_128003052_128003209	0.36	ENSG00000212451	.	319363	0.01
chr3_153850737_153851019	0.36	ARHGEF26	Rho guanine nucleotide exchange factor (GEF) 26	11649	0.22
chr11_95786586_95786916	0.36	MTMR2	myotubularin related protein 2	129292	0.05
chr7_38969302_38969595	0.36	VPS41	vacuolar protein sorting 41 homolog (S. cerevisiae)	288	0.94
chr11_92931221_92931372	0.36	SLC36A4	solute carrier family 36 (proton/amino acid symporter), member 4	167	0.97
chr8_130594633_130594805	0.36	ENSG00000266387	.	84806	0.07
chr14_75323168_75323351	0.36	PROX2	prospero homeobox 2	7278	0.14
chr4_91278223_91278374	0.36	ENSG00000252087	.	12976	0.31
chr11_75367473_75367624	0.36	MAP6	microtubule-associated protein 6	11931	0.14
chr13_88727217_88727368	0.36	ENSG00000223059	.	112883	0.08
chr1_21277303_21277509	0.36	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	9295	0.23
chr8_67042092_67042243	0.36	TRIM55	tripartite motif containing 55	2889	0.34
chr3_37860112_37860344	0.36	ENSG00000235257	.	2673	0.3
chr13_72142845_72142996	0.36	DACH1	dachshund homolog 1 (Drosophila)	297987	0.01
chr2_160374836_160375140	0.36	ENSG00000207117	.	17869	0.24
chr4_68312692_68312843	0.35	ENSG00000206629	.	17295	0.26
chr15_52436562_52436713	0.35	CTD-2184D3.7		6012	0.16
chr6_27570448_27570599	0.35	ENSG00000206671	.	6332	0.22
chr12_1427689_1428011	0.35	RP5-951N9.2		67149	0.11
chr2_232106617_232106773	0.35	ARMC9	armadillo repeat containing 9	6630	0.24
chr13_91067405_91067695	0.35	ENSG00000207858	.	184114	0.03
chr5_175893259_175893617	0.35	ENSG00000221373	.	14675	0.12
chr1_90408609_90408825	0.35	ENSG00000252797	.	44786	0.15
chr17_29553936_29554129	0.35	NF1	neurofibromin 1	26478	0.15
chr6_149727250_149727401	0.35	SUMO4	small ubiquitin-like modifier 4	5830	0.2
chr11_114034929_114035103	0.35	ENSG00000221112	.	77365	0.09
chr9_22165561_22165745	0.34	CDKN2B-AS1	CDKN2B antisense RNA 1	51976	0.16
chr1_27425346_27425645	0.34	SLC9A1	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	55478	0.1
chr8_99248451_99248632	0.34	ENSG00000252558	.	44000	0.14
chr11_116747490_116747649	0.34	SIK3-IT1	SIK3 intronic transcript 1 (non-protein coding)	13868	0.12
chr11_35954304_35954455	0.34	LDLRAD3	low density lipoprotein receptor class A domain containing 3	11152	0.18
chr16_48364740_48364935	0.34	LONP2	lon peptidase 2, peroxisomal	3386	0.26
chr5_36948326_36948572	0.34	NIPBL	Nipped-B homolog (Drosophila)	71557	0.13
chr5_143241658_143241809	0.34	HMHB1	histocompatibility (minor) HB-1	50007	0.18
chr9_35526012_35526444	0.33	RUSC2	RUN and SH3 domain containing 2	12401	0.15
chr17_15869540_15869896	0.33	ADORA2B	adenosine A2b receptor	21487	0.15
chr2_175018489_175018640	0.33	OLA1	Obg-like ATPase 1	64110	0.12
chr11_19265860_19266011	0.33	E2F8	E2F transcription factor 8	2768	0.28
chr2_174026267_174026418	0.33	MLK7-AS1	MLK7 antisense RNA 1	45998	0.16
chr5_115374031_115374427	0.33	ENSG00000220996	.	4729	0.15
chr3_51654767_51654946	0.33	RAD54L2	RAD54-like 2 (S. cerevisiae)	8551	0.17
chr5_160121113_160121264	0.33	CTC-529G1.1		8830	0.21
chr1_183430720_183430871	0.33	SMG7	SMG7 nonsense mediated mRNA decay factor	10711	0.21
chr1_212433899_212434288	0.33	PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	24786	0.16
chr21_23887924_23888075	0.33	ENSG00000263796	.	164993	0.04
chr6_106994075_106994866	0.33	AIM1	absent in melanoma 1	5441	0.23
chr10_77190817_77191121	0.33	RP11-399K21.10		377	0.87
chr7_105807957_105808108	0.33	ENSG00000201796	.	40581	0.17
chr11_103935040_103935191	0.32	PDGFD	platelet derived growth factor D	27361	0.2
chr2_54191777_54192195	0.32	ACYP2	acylphosphatase 2, muscle type	5989	0.21
chr9_74363230_74363515	0.32	TMEM2	transmembrane protein 2	19930	0.27
chr8_59084985_59085323	0.32	FAM110B	family with sequence similarity 110, member B	178041	0.03
chr2_101728983_101729400	0.32	ENSG00000265860	.	19160	0.19
chr5_139532409_139532571	0.32	CYSTM1	cysteine-rich transmembrane module containing 1	21737	0.12
chr8_131278471_131278622	0.32	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	19258	0.26
chr1_25458423_25458574	0.32	RP4-706G24.1		76132	0.08
chr3_18787817_18787968	0.32	ENSG00000228956	.	656	0.84
chr11_78101755_78101906	0.32	RP11-452H21.2		2723	0.27
chr17_58516951_58517102	0.32	C17orf64	chromosome 17 open reading frame 64	17156	0.18
chr2_135843202_135843353	0.32	ENSG00000238337	.	19973	0.17
chr5_151063563_151063813	0.32	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	1103	0.43
chr9_31590126_31590277	0.32	ENSG00000252313	.	703355	0.0
chr18_29260479_29260630	0.32	B4GALT6	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6	3913	0.17
chr7_102452212_102452699	0.31	ENSG00000252643	.	22597	0.16
chr11_8719978_8720129	0.31	ST5	suppression of tumorigenicity 5	3851	0.13
chr9_297842_297993	0.31	DOCK8	dedicator of cytokinesis 8	24847	0.18
chrX_135967912_135968067	0.31	RBMX	RNA binding motif protein, X-linked	5066	0.21
chr20_47448722_47448873	0.31	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	4377	0.31
chr1_174758122_174758399	0.31	RABGAP1L	RAB GTPase activating protein 1-like	10810	0.28
chr5_148645320_148645471	0.31	AFAP1L1	actin filament associated protein 1-like 1	6039	0.14
chr1_234639139_234639392	0.31	TARBP1	TAR (HIV-1) RNA binding protein 1	24416	0.19
chr1_9962207_9962358	0.31	CTNNBIP1	catenin, beta interacting protein 1	8039	0.14
chr12_89777034_89777222	0.31	DUSP6	dual specificity phosphatase 6	30080	0.2
chr10_73104848_73104999	0.31	ENSG00000238918	.	19838	0.18
chr8_96875884_96876062	0.31	ENSG00000223297	.	184830	0.03
chr4_38077270_38077549	0.31	TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	29917	0.24
chr3_171528829_171529427	0.31	PLD1	phospholipase D1, phosphatidylcholine-specific	844	0.52
chr12_77777777_77777928	0.31	AC073528.1		172716	0.04
chr1_234755566_234755985	0.31	IRF2BP2	interferon regulatory factor 2 binding protein 2	10504	0.19
chr20_5837496_5837647	0.30	ENSG00000202380	.	33130	0.16
chr2_208734859_208735279	0.30	AC083900.1		430	0.86
chr2_160470412_160470682	0.30	AC009506.1		1260	0.4
chr5_127059262_127059522	0.30	CTC-548H10.2		59671	0.14
chr12_113251939_113252090	0.30	RPH3A	rabphilin 3A homolog (mouse)	14110	0.24
chr2_192241823_192241993	0.30	ENSG00000252130	.	6244	0.26
chr12_6292503_6292996	0.30	CD9	CD9 molecule	16132	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HLF_TEF

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.1	0.3	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812)
0.1	0.1	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.1	0.2	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.1	0.4	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.1	0.2	GO:0001714	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.1	0.2	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.1	0.2	GO:0060058	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.1	0.2	GO:0071436	sodium ion export(GO:0071436)
0.1	0.2	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.2	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.2	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.2	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.2	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.1	GO:0051142	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0	0.4	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.0	GO:0048087	positive regulation of developmental pigmentation(GO:0048087)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.2	GO:2000831	corticosteroid hormone secretion(GO:0035930) regulation of steroid hormone secretion(GO:2000831) regulation of corticosteroid hormone secretion(GO:2000846)
0.0	0.2	GO:0045634	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0070339	response to bacterial lipoprotein(GO:0032493) response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221)
0.0	0.1	GO:0042640	anagen(GO:0042640)
0.0	0.1	GO:0045410	positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0	0.1	GO:0010566	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.1	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0051877	pigment granule aggregation in cell center(GO:0051877)
0.0	0.1	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.0	GO:0033591	response to L-ascorbic acid(GO:0033591)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.2	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0046049	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.2	GO:0031274	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0044557	relaxation of smooth muscle(GO:0044557) relaxation of vascular smooth muscle(GO:0060087)
0.0	0.1	GO:0033131	regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.0	0.0	GO:0071224	cellular response to peptidoglycan(GO:0071224)
0.0	0.1	GO:0009415	response to water deprivation(GO:0009414) response to water(GO:0009415)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.2	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.1	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.0	0.1	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0034086	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.1	GO:0030219	megakaryocyte differentiation(GO:0030219)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.2	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
0.0	0.1	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.1	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.1	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.2	GO:0007567	parturition(GO:0007567)
0.0	0.1	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.4	GO:0006662	glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.1	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.1	GO:0045631	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0048853	forebrain morphogenesis(GO:0048853)
0.0	0.1	GO:1903670	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.0	0.1	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.1	GO:0035609	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.1	GO:0008615	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.1	GO:0043461	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.1	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.0	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0032700	negative regulation of interleukin-17 production(GO:0032700)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.2	GO:0007128	meiotic prophase I(GO:0007128)
0.0	0.0	GO:0048245	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.0	GO:0002227	innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385)
0.0	0.2	GO:0045668	negative regulation of osteoblast differentiation(GO:0045668)
0.0	0.1	GO:1903054	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0043302	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.1	GO:0006734	NADH metabolic process(GO:0006734)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.0	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.1	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.0	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.2	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.1	GO:0032782	canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0	0.0	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.0	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.2	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0	0.0	GO:0048266	behavioral response to pain(GO:0048266)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.0	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.1	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.0	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.0	GO:0001865	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.0	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.1	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.0	GO:1901970	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0	0.0	GO:0060693	regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.0	0.2	GO:0046464	triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0	0.1	GO:0007635	chemosensory behavior(GO:0007635)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.0	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.0	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.1	GO:0045351	type I interferon biosynthetic process(GO:0045351)
0.0	0.0	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.1	GO:0042095	interferon-gamma biosynthetic process(GO:0042095) regulation of interferon-gamma biosynthetic process(GO:0045072) positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.0	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.0	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.0	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.0	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.0	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.0	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0060612	adipose tissue development(GO:0060612)
0.0	0.1	GO:0047497	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0	0.1	GO:0097435	extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0	0.1	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.0	GO:0052555	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308) positive regulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052555) positive regulation by symbiont of host immune response(GO:0052556)
0.0	0.1	GO:0034405	response to fluid shear stress(GO:0034405)
0.0	0.0	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.0	GO:0021903	rostrocaudal neural tube patterning(GO:0021903)
0.0	0.0	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.0	GO:0030300	regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.0	0.0	GO:0046618	drug export(GO:0046618)
0.0	0.0	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.0	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.0	GO:0016999	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.0	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0044091	membrane biogenesis(GO:0044091)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	0.2	GO:0005638	lamin filament(GO:0005638)
0.0	0.4	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.2	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.3	GO:0000145	exocyst(GO:0000145)
0.0	0.3	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.2	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.2	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.3	GO:0030897	HOPS complex(GO:0030897)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.1	GO:0070083	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.2	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.2	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.4	GO:0001533	cornified envelope(GO:0001533)
0.0	0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.7	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0045283	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.1	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.0	GO:0010369	chromocenter(GO:0010369)
0.0	0.0	GO:0000805	X chromosome(GO:0000805)
0.0	0.1	GO:0005861	troponin complex(GO:0005861)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	0.0	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.2	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	0.2	GO:0030057	desmosome(GO:0030057)
0.0	0.0	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.0	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.0	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.0	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.0	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.2	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.1	GO:0031082	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1	0.3	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.1	0.3	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	0.2	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1	0.2	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1	0.3	GO:0030955	potassium ion binding(GO:0030955)
0.1	0.3	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1	0.2	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.1	0.2	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.1	0.3	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.2	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.3	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.2	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.3	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.2	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.2	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.6	GO:0005355	glucose transmembrane transporter activity(GO:0005355)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.4	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.1	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.2	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.4	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.2	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.2	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.2	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.2	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.5	GO:0030552	cAMP binding(GO:0030552)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.1	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.0	GO:0008061	chitin binding(GO:0008061)
0.0	0.1	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.0	GO:0000104	succinate dehydrogenase activity(GO:0000104)
0.0	0.0	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.2	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.2	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.1	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.1	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.0	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0030343	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.0	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.3	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.2	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.1	GO:0004445	inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.0	0.1	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.0	0.1	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.1	GO:0030250	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0	0.0	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0005112	Notch binding(GO:0005112)
0.0	0.0	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.0	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.0	GO:0034648	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.1	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.1	GO:0034739	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.1	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.1	GO:0044390	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.0	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0031210	phosphatidylcholine binding(GO:0031210)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.0	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.1	GO:0022821	potassium ion antiporter activity(GO:0022821)
0.0	0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.0	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.0	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.0	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.0	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.2	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.0	0.0	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.3	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.0	GO:0034584	piRNA binding(GO:0034584)
0.0	0.0	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.0	GO:0004802	transketolase activity(GO:0004802)
0.0	0.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.0	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0005451	monovalent cation:proton antiporter activity(GO:0005451)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.0	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.1	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.0	0.1	GO:0008198	ferrous iron binding(GO:0008198)
0.0	0.0	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.1	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.5	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.8	PID ARF6 PATHWAY	Arf6 signaling events
0.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.3	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	PID S1P S1P4 PATHWAY	S1P4 pathway
0.2	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.1	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	PID IL27 PATHWAY	IL27-mediated signaling events
0.1	PID AP1 PATHWAY	AP-1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.0	0.0	REACTOME BILE ACID AND BILE SALT METABOLISM	Genes involved in Bile acid and bile salt metabolism
0.0	0.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.3	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.3	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.3	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.0	REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0	0.3	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.2	REACTOME ACYL CHAIN REMODELLING OF PC	Genes involved in Acyl chain remodelling of PC
0.0	0.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.2	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.0	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	0.3	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.5	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.5	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.2	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.2	REACTOME BOTULINUM NEUROTOXICITY	Genes involved in Botulinum neurotoxicity
0.0	0.1	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0	0.2	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	0.1	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.0	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.4	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.0	0.1	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.0	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	0.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)