Project

ENCODE: H3K4me1 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HNF1A_HNF1B

Z-value: 0.80

Motif logo

Transcription factors associated with HNF1A_HNF1B

Gene Symbol	Gene ID	Gene Info
HNF1A Ensembl NCBI GeneCards UniProt	ENSG00000135100.13	HNF1A
HNF1B Ensembl NCBI GeneCards UniProt	ENSG00000108753.8	HNF1B

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HNF1B	chr17_36135419_36135570	30257	0.150237	-0.89	1.1e-03	Click!
HNF1B	chr17_36112352_36112607	7242	0.192190	0.80	1.0e-02	Click!
HNF1B	chr17_36122844_36122995	17682	0.173448	-0.78	1.4e-02	Click!
HNF1B	chr17_36121536_36121745	16403	0.175492	-0.70	3.5e-02	Click!
HNF1B	chr17_36124947_36125098	19785	0.169880	-0.63	7.1e-02	Click!

Activity of the HNF1A_HNF1B motif across conditions

Conditions sorted by the z-value of the HNF1A_HNF1B motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_69405435_69405631	0.59	ACTN1	actinin, alpha 1	8732	0.24
chr1_68214159_68214518	0.46	ENSG00000238778	.	23998	0.19
chr10_97849004_97849155	0.45	ENTPD1-AS1	ENTPD1 antisense RNA 1	833	0.59
chr9_20320271_20320422	0.43	ENSG00000221744	.	25344	0.21
chr1_181121299_181121450	0.39	IER5	immediate early response 5	63736	0.13
chr7_37071372_37071523	0.39	ELMO1-AS1	ELMO1 antisense RNA 1	34046	0.17
chr10_29924859_29925052	0.39	SVIL	supervillin	1054	0.57
chr18_68086526_68086677	0.38	ENSG00000264059	.	57142	0.13
chr14_50691962_50692201	0.36	SOS2	son of sevenless homolog 2 (Drosophila)	5946	0.22
chr3_42066075_42066314	0.36	ULK4	unc-51 like kinase 4	62272	0.12
chr11_16945886_16946397	0.33	PLEKHA7	pleckstrin homology domain containing, family A member 7	43236	0.13
chr4_114394825_114395109	0.33	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	40031	0.16
chr6_40925892_40926043	0.32	UNC5CL	unc-5 homolog C (C. elegans)-like	76907	0.08
chr3_58057429_58057580	0.32	FLNB	filamin B, beta	6552	0.27
chr2_24269080_24269320	0.31	ENSG00000222940	.	495	0.58
chr3_183016185_183016744	0.31	B3GNT5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	33332	0.16
chr7_38254764_38254915	0.31	STARD3NL	STARD3 N-terminal like	36842	0.23
chr4_124571341_124571610	0.31	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	250352	0.02
chr18_805710_806203	0.30	YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	6283	0.16
chr8_70745558_70745875	0.30	SLCO5A1	solute carrier organic anion transporter family, member 5A1	91	0.91
chr3_188599582_188599733	0.29	TPRG1	tumor protein p63 regulated 1	65346	0.14
chr5_121498494_121498645	0.29	CTC-441N14.1		6859	0.2
chr11_117695326_117695570	0.29	FXYD2	FXYD domain containing ion transport regulator 2	11	0.97
chr17_47440332_47440604	0.29	ZNF652	zinc finger protein 652	633	0.61
chr12_27487334_27487485	0.29	ARNTL2	aryl hydrocarbon receptor nuclear translocator-like 2	1421	0.49
chr18_10169648_10169799	0.29	ENSG00000263630	.	164529	0.03
chr3_81777225_81777376	0.29	GBE1	glucan (1,4-alpha-), branching enzyme 1	15480	0.31
chr4_24606533_24606684	0.28	DHX15	DEAH (Asp-Glu-Ala-His) box helicase 15	20435	0.22
chrX_119689036_119689385	0.28	CUL4B	cullin 4B	4588	0.21
chr8_49322257_49322678	0.28	ENSG00000252710	.	101877	0.08
chr6_74512837_74512988	0.28	RP11-553A21.3		107058	0.06
chr4_169408783_169408934	0.27	DDX60L	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	7193	0.2
chr11_124595039_124595293	0.27	NRGN	neurogranin (protein kinase C substrate, RC3)	14576	0.1
chr17_67498171_67498584	0.27	MAP2K6	mitogen-activated protein kinase kinase 6	30	0.99
chr7_45927984_45928135	0.26	IGFBP1	insulin-like growth factor binding protein 1	37	0.98
chr4_38387684_38387835	0.26	ENSG00000221495	.	147525	0.04
chr15_73927173_73927324	0.26	NPTN	neuroplastin	773	0.72
chr15_64636500_64636651	0.26	ENSG00000252774	.	1837	0.25
chr15_64927439_64927681	0.26	ENSG00000207223	.	17527	0.14
chr6_154640196_154640597	0.25	IPCEF1	interaction protein for cytohesin exchange factors 1	10819	0.3
chr3_192534775_192534926	0.25	FGF12	fibroblast growth factor 12	49297	0.16
chr16_12707264_12707435	0.25	CTD-3037G24.3		2448	0.33
chr2_208337340_208337637	0.25	CREB1	cAMP responsive element binding protein 1	56973	0.13
chr3_183563309_183563581	0.25	PARL	presenilin associated, rhomboid-like	1383	0.34
chr10_98623724_98623875	0.24	LCOR	ligand dependent nuclear receptor corepressor	31062	0.15
chr3_172312196_172312406	0.24	AC007919.2	HCG1787166; PRO1163; Uncharacterized protein	49182	0.13
chr20_1921396_1921547	0.24	RP4-684O24.5		6421	0.23
chr4_79489691_79489842	0.24	ANXA3	annexin A3	14692	0.23
chr2_230793147_230793445	0.23	TRIP12	thyroid hormone receptor interactor 12	5341	0.14
chr15_67419351_67419566	0.23	SMAD3	SMAD family member 3	983	0.62
chrX_17581294_17581554	0.23	NHS-AS1	NHS antisense RNA 1	5916	0.25
chr10_63718660_63718935	0.23	ENSG00000221272	.	32020	0.21
chr7_32538317_32538480	0.23	AVL9	AVL9 homolog (S. cerevisiase)	3076	0.29
chr18_13491175_13491326	0.22	RP11-53B2.2		4789	0.11
chr10_111816096_111816353	0.22	ADD3	adducin 3 (gamma)	48502	0.14
chr2_44518783_44519008	0.22	SLC3A1	solute carrier family 3 (amino acid transporter heavy chain), member 1	6261	0.21
chr5_142554814_142554965	0.22	ARHGAP26-IT1	ARHGAP26 intronic transcript 1 (non-protein coding)	17176	0.24
chr13_114881324_114881475	0.22	RASA3-IT1	RASA3 intronic transcript 1 (non-protein coding)	7104	0.23
chr15_85937202_85937353	0.22	ENSG00000251891	.	4162	0.24
chr6_108971832_108971983	0.22	FOXO3	forkhead box O3	5642	0.32
chr1_120174414_120175022	0.21	ZNF697	zinc finger protein 697	15678	0.18
chr5_64500241_64500433	0.21	ENSG00000207439	.	81141	0.11
chr5_133387222_133387373	0.21	VDAC1	voltage-dependent anion channel 1	46473	0.14
chr16_81030908_81031149	0.21	CMC2	C-x(9)-C motif containing 2	1236	0.36
chr2_43986548_43986990	0.21	ENSG00000252490	.	12720	0.19
chr12_25648509_25648660	0.21	IFLTD1	intermediate filament tail domain containing 1	24311	0.23
chr12_46867328_46867682	0.21	SLC38A2	solute carrier family 38, member 2	100855	0.08
chr7_22627428_22627634	0.21	AC002480.4		1793	0.36
chr9_14251173_14251324	0.21	NFIB	nuclear factor I/B	56764	0.15
chrX_129243328_129243479	0.21	ELF4	E74-like factor 4 (ets domain transcription factor)	933	0.6
chr6_132654884_132655035	0.20	MOXD1	monooxygenase, DBH-like 1	41245	0.19
chr18_66372478_66372744	0.20	TMX3	thioredoxin-related transmembrane protein 3	9683	0.22
chr17_71040137_71040288	0.20	SLC39A11	solute carrier family 39, member 11	45691	0.17
chr21_34905841_34905992	0.20	GART	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	8504	0.13
chr1_200865216_200865405	0.20	C1orf106	chromosome 1 open reading frame 106	1361	0.42
chr1_68643879_68644030	0.20	ENSG00000221203	.	5339	0.24
chr9_74377924_74378411	0.20	TMEM2	transmembrane protein 2	5135	0.32
chr11_86431921_86432072	0.20	ME3	malic enzyme 3, NADP(+)-dependent, mitochondrial	48318	0.17
chr2_169387098_169387498	0.20	ENSG00000265694	.	52155	0.13
chr9_3359879_3360030	0.19	RFX3	regulatory factor X, 3 (influences HLA class II expression)	13190	0.3
chr6_117818099_117818250	0.19	DCBLD1	discoidin, CUB and LCCL domain containing 1	14349	0.17
chr4_76584048_76584199	0.19	ENSG00000201644	.	3274	0.22
chr15_69850121_69850272	0.19	ENSG00000207119	.	99708	0.06
chr3_18177094_18177245	0.19	RP11-158G18.1		273958	0.02
chr9_22104098_22104249	0.19	CDKN2B-AS1	CDKN2B antisense RNA 1	9504	0.26
chr7_47613250_47613541	0.19	TNS3	tensin 3	7834	0.3
chr2_109203925_109204163	0.19	LIMS1	LIM and senescent cell antigen-like domains 1	723	0.74
chr2_30336938_30337089	0.19	AC016907.3		22186	0.18
chr10_89142685_89142836	0.18	NUTM2D	NUT family member 2D	18014	0.21
chr15_38549505_38549656	0.18	SPRED1	sprouty-related, EVH1 domain containing 1	4198	0.36
chr2_202270772_202271289	0.18	ENSG00000202008	.	17206	0.15
chr6_16367315_16367466	0.18	ENSG00000265642	.	61364	0.14
chr10_30388154_30388305	0.18	KIAA1462	KIAA1462	39776	0.21
chr1_183812842_183812993	0.18	RGL1	ral guanine nucleotide dissociation stimulator-like 1	38627	0.18
chr3_183266299_183266524	0.18	KLHL6-AS1	KLHL6 antisense RNA 1	112	0.96
chr5_130601387_130601538	0.18	CDC42SE2	CDC42 small effector 2	1669	0.51
chr21_36265275_36265757	0.18	RUNX1	runt-related transcription factor 1	3429	0.38
chr1_20916896_20917047	0.17	CDA	cytidine deaminase	1530	0.37
chr7_135015211_135015362	0.17	STRA8	stimulated by retinoic acid 8	98555	0.06
chr6_130645263_130645558	0.17	SAMD3	sterile alpha motif domain containing 3	41160	0.17
chr10_104103101_104103252	0.17	NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	50691	0.08
chr3_71634599_71634767	0.17	FOXP1	forkhead box P1	1543	0.42
chr8_121080549_121080727	0.17	COL14A1	collagen, type XIV, alpha 1	37178	0.21
chr7_155601790_155601976	0.17	SHH	sonic hedgehog	117	0.97
chr6_2103859_2104525	0.17	GMDS	GDP-mannose 4,6-dehydratase	72033	0.13
chr4_100007595_100007746	0.17	ADH5	alcohol dehydrogenase 5 (class III), chi polypeptide	1303	0.38
chr3_156252924_156253075	0.17	RP11-305K5.1		10963	0.22
chr13_27132620_27132950	0.17	WASF3	WAS protein family, member 3	898	0.72
chr9_27094212_27094497	0.17	TEK	TEK tyrosine kinase, endothelial	14785	0.23
chr9_21543413_21543564	0.17	MIR31HG	MIR31 host gene (non-protein coding)	16180	0.15
chr2_233432775_233432926	0.17	EIF4E2	eukaryotic translation initiation factor 4E family member 2	5934	0.11
chrX_39967563_39967714	0.17	BCOR	BCL6 corepressor	10982	0.31
chr6_43730965_43731135	0.17	VEGFA	vascular endothelial growth factor A	6900	0.18
chr7_116228829_116229027	0.17	AC006159.4		17640	0.18
chr12_65700883_65701407	0.16	MSRB3	methionine sulfoxide reductase B3	19510	0.22
chr9_123960312_123961002	0.16	RAB14	RAB14, member RAS oncogene family	3490	0.19
chr13_20769719_20769870	0.16	GJB2	gap junction protein, beta 2, 26kDa	2757	0.25
chr11_27417260_27417411	0.16	CCDC34	coiled-coil domain containing 34	31920	0.18
chr1_234953186_234953405	0.16	ENSG00000201638	.	20425	0.25
chr15_71346441_71346592	0.16	THSD4	thrombospondin, type I, domain containing 4	42775	0.16
chr5_133939031_133939182	0.16	SAR1B	SAR1 homolog B (S. cerevisiae)	9670	0.17
chr18_452761_452993	0.16	RP11-720L2.2		28461	0.17
chr6_12343879_12344030	0.16	EDN1	endothelin 1	53358	0.16
chr3_183947384_183948074	0.16	VWA5B2	von Willebrand factor A domain containing 5B2	488	0.65
chr3_152153870_152154021	0.16	ENSG00000201217	.	13116	0.21
chr5_95683555_95683706	0.16	PCSK1	proprotein convertase subtilisin/kexin type 1	84234	0.09
chr6_25311839_25311990	0.16	ENSG00000207286	.	24153	0.15
chr11_111999683_111999892	0.16	IL18	interleukin 18 (interferon-gamma-inducing factor)	35010	0.08
chr2_29339694_29340047	0.16	CLIP4	CAP-GLY domain containing linker protein family, member 4	1191	0.44
chr7_42302451_42302602	0.16	GLI3	GLI family zinc finger 3	25868	0.28
chr14_58748062_58749029	0.16	RP11-349A22.5		5196	0.12
chr3_185431049_185431200	0.16	C3orf65	chromosome 3 open reading frame 65	44	0.98
chr20_34380481_34380768	0.16	PHF20	PHD finger protein 20	20676	0.13
chr1_33414688_33414839	0.16	RNF19B	ring finger protein 19B	15523	0.12
chr12_54383579_54383730	0.16	HOXC6	homeobox C6	754	0.31
chr7_30836266_30836417	0.16	AC004691.5		6685	0.2
chr7_110872801_110872972	0.16	ENSG00000238922	.	123473	0.06
chr7_139473808_139474066	0.16	HIPK2	homeodomain interacting protein kinase 2	3580	0.27
chr4_41179011_41179162	0.16	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	37389	0.15
chr8_17220869_17221020	0.16	MTMR7	myotubularin related protein 7	49892	0.15
chr15_85455088_85455239	0.15	ENSG00000207037	.	26590	0.13
chr8_38029592_38029743	0.15	BAG4	BCL2-associated athanogene 4	4439	0.11
chr6_136760823_136760974	0.15	MAP7	microtubule-associated protein 7	27115	0.21
chr3_48733781_48734150	0.15	IP6K2	inositol hexakisphosphate kinase 2	950	0.42
chr6_46458096_46458346	0.15	RCAN2	regulator of calcineurin 2	878	0.55
chr4_38084935_38085086	0.15	TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	37518	0.21
chr6_169615833_169615984	0.15	XXyac-YX65C7_A.2		2559	0.38
chr1_8156252_8156403	0.15	ERRFI1	ERBB receptor feedback inhibitor 1	69959	0.1
chr10_71529428_71529579	0.15	COL13A1	collagen, type XIII, alpha 1	32141	0.17
chr5_88717098_88717249	0.15	MEF2C-AS1	MEF2C antisense RNA 1	2549	0.45
chr6_144586213_144586364	0.15	UTRN	utrophin	20549	0.24
chr6_52415213_52415364	0.14	TRAM2	translocation associated membrane protein 2	26425	0.21
chr6_2020825_2021145	0.14	GMDS	GDP-mannose 4,6-dehydratase	155240	0.04
chr3_189743016_189743167	0.14	ENSG00000265045	.	88632	0.08
chr8_129031222_129031516	0.14	ENSG00000222501	.	8512	0.18
chr1_183483781_183483932	0.14	ENSG00000265042	.	3957	0.25
chr19_12722676_12723040	0.14	ZNF791	zinc finger protein 791	1090	0.26
chr10_91092779_91093035	0.14	IFIT3	interferon-induced protein with tetratricopeptide repeats 3	666	0.62
chr5_61564187_61564338	0.14	KIF2A	kinesin heavy chain member 2A	37727	0.2
chr8_125266983_125267210	0.14	ENSG00000206724	.	5791	0.28
chr12_79098466_79098617	0.14	SYT1	synaptotagmin I	159232	0.04
chr12_56609980_56610131	0.14	RNF41	ring finger protein 41	5430	0.07
chr10_11602345_11602496	0.14	USP6NL	USP6 N-terminal like	13316	0.25
chr5_134707593_134707838	0.14	H2AFY	H2A histone family, member Y	27186	0.14
chr3_135710315_135710559	0.14	PPP2R3A	protein phosphatase 2, regulatory subunit B'', alpha	25851	0.25
chr17_57746657_57747029	0.14	CLTC	clathrin, heavy chain (Hc)	14424	0.17
chr17_29889114_29889342	0.14	ENSG00000221038	.	1685	0.21
chr4_169361836_169361987	0.14	DDX60L	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	15299	0.2
chr10_33995531_33995682	0.14	NRP1	neuropilin 1	370416	0.01
chr17_50225184_50225335	0.14	CA10	carbonic anhydrase X	10164	0.3
chr7_17411629_17411780	0.14	ENSG00000199473	.	1246	0.58
chr8_87496135_87496286	0.14	CPNE3	copine III	849	0.58
chrX_149881301_149881600	0.14	MTMR1	myotubularin related protein 1	5699	0.3
chr12_13054850_13055147	0.14	GPRC5A	G protein-coupled receptor, family C, group 5, member A	7005	0.15
chr10_31255665_31255816	0.14	ZNF438	zinc finger protein 438	17615	0.26
chr7_89974617_89974768	0.14	GTPBP10	GTP-binding protein 10 (putative)	1287	0.45
chr11_14375636_14375787	0.14	RRAS2	related RAS viral (r-ras) oncogene homolog 2	335	0.93
chr4_123795832_123795983	0.14	RP11-170N16.3		9960	0.18
chr6_143193207_143193806	0.14	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	35322	0.21
chr11_113186702_113186853	0.14	TTC12	tetratricopeptide repeat domain 12	186	0.92
chr1_27039284_27039619	0.14	ARID1A	AT rich interactive domain 1A (SWI-like)	14748	0.14
chr20_19795494_19795742	0.13	AL121761.2	Uncharacterized protein	56939	0.12
chr15_71006405_71006665	0.13	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	10921	0.26
chr3_100112860_100113011	0.13	LNP1	leukemia NUP98 fusion partner 1	7102	0.2
chr3_150936070_150936221	0.13	GPR171	G protein-coupled receptor 171	15157	0.14
chr13_98908338_98908489	0.13	RP11-573N10.1		22509	0.17
chr18_42313110_42313658	0.13	SETBP1	SET binding protein 1	36255	0.24
chr10_11060742_11061158	0.13	CELF2	CUGBP, Elav-like family member 2	844	0.61
chr9_127428096_127428247	0.13	MIR181A2HG	MIR181A2 host gene (non-protein coding)	7425	0.17
chr4_185709233_185709384	0.13	ACSL1	acyl-CoA synthetase long-chain family member 1	14281	0.18
chr12_889095_889427	0.13	ENSG00000221439	.	1038	0.58
chr2_173952072_173952223	0.13	MLTK	Mitogen-activated protein kinase kinase kinase MLT	3200	0.29
chr18_55480395_55480546	0.13	ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1	10143	0.24
chr15_52627311_52627462	0.13	MYO5A	myosin VA (heavy chain 12, myoxin)	16193	0.2
chr3_161027813_161027964	0.13	SPTSSB	serine palmitoyltransferase, small subunit B	61401	0.14
chr14_89019667_89019818	0.13	PTPN21	protein tyrosine phosphatase, non-receptor type 21	1335	0.33
chr6_144171782_144171933	0.13	LTV1	LTV1 homolog (S. cerevisiae)	7376	0.24
chr2_98566489_98566757	0.13	ENSG00000238719	.	37043	0.17
chr10_3848729_3848956	0.13	KLF6	Kruppel-like factor 6	21369	0.22
chr10_131555762_131556161	0.13	RP11-109A6.2		56140	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.1	0.3	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.2	GO:0060291	long-term synaptic potentiation(GO:0060291)
0.0	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.2	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.2	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.2	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0022030	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0071692	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.1	GO:0006655	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0	0.1	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.1	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.0	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.1	GO:0010988	regulation of low-density lipoprotein particle clearance(GO:0010988)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0006188	IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0016540	protein autoprocessing(GO:0016540)
0.0	0.0	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.0	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.0	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.0	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.0	GO:0071803	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.1	GO:0046149	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.0	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.0	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.0	GO:0010842	retina layer formation(GO:0010842)
0.0	0.0	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.0	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.0	GO:0000101	sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0	0.0	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0008347	glial cell migration(GO:0008347)
0.0	0.0	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.0	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.0	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.0	GO:0060457	negative regulation of digestive system process(GO:0060457)
0.0	0.0	GO:0007386	compartment pattern specification(GO:0007386)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0071437	invadopodium(GO:0071437)
0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.2	GO:0005915	zonula adherens(GO:0005915)
0.2	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1	GO:0031143	pseudopodium(GO:0031143)
0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.1	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	GO:0032059	bleb(GO:0032059)
0.0	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.1	GO:0031528	microvillus membrane(GO:0031528)
0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1	0.2	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.2	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.0	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.3	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.2	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.0	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.0	GO:0015184	L-cystine transmembrane transporter activity(GO:0015184)
0.0	0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.0	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.0	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.0	GO:0005534	galactose binding(GO:0005534)
0.0	0.0	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.0	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.2	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism