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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for HOXA2_HOXB1

Z-value: 2.07

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Transcription factors associated with HOXA2_HOXB1

Gene Symbol	Gene ID	Gene Info
HOXA2 Ensembl NCBI GeneCards UniProt	ENSG00000105996.5	homeobox A2
HOXB1 Ensembl NCBI GeneCards UniProt	ENSG00000120094.6	homeobox B1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr7_27143279_27143430	HOXA2	924	0.314509	0.82	7.1e-03	Click!
chr7_27143578_27143729	HOXA2	1223	0.228182	0.72	2.9e-02	Click!
chr7_27144778_27144929	HOXA2	2423	0.113224	0.55	1.2e-01	Click!
chr7_27142627_27142778	HOXA2	272	0.781009	0.44	2.4e-01	Click!
chr7_27144416_27144567	HOXA2	2061	0.130943	0.10	7.9e-01	Click!
chr17_46599467_46599618	HOXB1	8730	0.091520	0.77	1.5e-02	Click!
chr17_46599711_46599862	HOXB1	8486	0.091736	0.71	3.1e-02	Click!
chr17_46583596_46583747	HOXB1	24601	0.083338	0.55	1.3e-01	Click!
chr17_46590516_46590795	HOXB1	17617	0.087363	-0.51	1.6e-01	Click!
chr17_46590286_46590437	HOXB1	17911	0.087227	-0.42	2.6e-01	Click!

Activity of the HOXA2_HOXB1 motif across conditions

Conditions sorted by the z-value of the HOXA2_HOXB1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_120009918_120010346	1.42	STEAP3-AS1	STEAP3 antisense RNA 1	3485	0.25
chr3_156480192_156480343	1.32	LEKR1	leucine, glutamate and lysine rich 1	63822	0.12
chr1_87243934_87244085	1.28	SH3GLB1	SH3-domain GRB2-like endophilin B1	73431	0.09
chr2_43269199_43269510	1.28	ENSG00000207087	.	49278	0.18
chr17_36623721_36623872	1.17	ARHGAP23	Rho GTPase activating protein 23	4384	0.19
chr2_105941635_105941786	1.17	TGFBRAP1	transforming growth factor, beta receptor associated protein 1	4781	0.19
chr1_40358181_40358689	1.08	RP1-118J21.5		4982	0.14
chr8_104154978_104155229	1.08	C8orf56	chromosome 8 open reading frame 56	1400	0.28
chr13_53698828_53698979	1.05	OLFM4	olfactomedin 4	96009	0.09
chr1_59629351_59629568	1.04	FGGY	FGGY carbohydrate kinase domain containing	132851	0.06
chr7_107612016_107612167	1.04	ENSG00000238297	.	28336	0.14
chr12_95510407_95510956	1.03	FGD6	FYVE, RhoGEF and PH domain containing 6	68	0.98
chr7_79780099_79780250	1.03	GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	15103	0.27
chr11_130667785_130667936	1.02	SNX19	sorting nexin 19	95909	0.08
chr8_103140534_103140777	1.01	ENSG00000266756	.	2995	0.26
chr21_43050861_43051153	1.01	ENSG00000252771	.	26164	0.2
chr1_234998930_234999119	0.98	ENSG00000201638	.	25304	0.21
chr2_145853430_145853638	0.98	ENSG00000253036	.	239104	0.02
chr12_63087483_63087634	0.94	ENSG00000238475	.	42603	0.15
chr1_118370111_118370262	0.94	GDAP2	ganglioside induced differentiation associated protein 2	102020	0.07
chr20_19739352_19739650	0.93	AL121761.2	Uncharacterized protein	822	0.67
chr14_81893807_81893958	0.92	STON2	stonin 2	134	0.98
chr2_9391901_9392219	0.92	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	45166	0.18
chr11_43529872_43530198	0.92	ENSG00000211568	.	51171	0.12
chr16_82104059_82104210	0.91	HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	2252	0.28
chr8_119452951_119453252	0.90	SAMD12	sterile alpha motif domain containing 12	140020	0.05
chr15_52138768_52139605	0.89	TMOD3	tropomodulin 3 (ubiquitous)	15849	0.15
chr3_133289948_133290170	0.88	CDV3	CDV3 homolog (mouse)	2515	0.29
chr15_74880720_74881033	0.87	CLK3	CDC-like kinase 3	19837	0.14
chr7_46330925_46331076	0.86	ENSG00000239004	.	315963	0.01
chr15_56115500_56115651	0.85	ENSG00000221218	.	62275	0.12
chr4_143738912_143739452	0.84	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	28261	0.27
chr11_19221880_19222197	0.82	CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	1551	0.37
chr5_52630256_52630554	0.81	FST	follistatin	145834	0.04
chr6_111984071_111984222	0.81	ENSG00000239015	.	16516	0.19
chr1_172077899_172078050	0.81	ENSG00000207949	.	30073	0.16
chr2_20795415_20795848	0.80	HS1BP3-IT1	HS1BP3 intronic transcript 1 (non-protein coding)	3323	0.28
chr5_141683908_141684059	0.79	SPRY4	sprouty homolog 4 (Drosophila)	19764	0.21
chr1_68036465_68036756	0.79	ENSG00000207504	.	29800	0.2
chr5_133928395_133928546	0.79	SAR1B	SAR1 homolog B (S. cerevisiae)	20306	0.15
chr2_39858801_39859100	0.78	TMEM178A	transmembrane protein 178A	34109	0.21
chr11_102867617_102867768	0.78	MMP13	matrix metallopeptidase 13 (collagenase 3)	41229	0.15
chr3_8979557_8979708	0.75	ENSG00000199815	.	6453	0.22
chr16_54482153_54482558	0.75	ENSG00000264079	.	100953	0.08
chr10_126841952_126842103	0.74	CTBP2	C-terminal binding protein 2	5258	0.31
chr20_56282141_56282292	0.74	PMEPA1	prostate transmembrane protein, androgen induced 1	2600	0.37
chr3_29737473_29737684	0.74	RBMS3-AS2	RBMS3 antisense RNA 2	53278	0.18
chr2_30889081_30889292	0.74	CAPN13	calpain 13	141125	0.05
chr20_22817162_22817313	0.74	ENSG00000265151	.	103298	0.07
chr4_160220032_160220325	0.73	ENSG00000216089	.	3312	0.3
chr9_125810997_125811288	0.73	GPR21	G protein-coupled receptor 21	14336	0.17
chr12_2445876_2446299	0.73	CACNA1C-IT3	CACNA1C intronic transcript 3 (non-protein coding)	67145	0.12
chr5_14266017_14266168	0.72	TRIO	trio Rho guanine nucleotide exchange factor	24994	0.28
chr10_75653009_75653160	0.72	PLAU	plasminogen activator, urokinase	15851	0.12
chr9_14275341_14275492	0.71	NFIB	nuclear factor I/B	32596	0.21
chr20_1450275_1450457	0.71	NSFL1C	NSFL1 (p97) cofactor (p47)	1949	0.26
chr3_5114211_5114362	0.71	ENSG00000207283	.	13678	0.2
chrX_45482348_45482499	0.71	ENSG00000207870	.	123271	0.06
chr16_18970727_18970878	0.70	TMC7	transmembrane channel-like 7	24454	0.12
chr17_17317270_17317683	0.70	ENSG00000201741	.	46282	0.12
chr16_66300326_66300572	0.69	ENSG00000201999	.	35263	0.19
chr6_143645528_143645685	0.69	AL031320.1		113969	0.05
chr2_33239208_33239359	0.69	ENSG00000252502	.	22892	0.22
chr8_23656747_23656898	0.68	ENSG00000207027	.	7068	0.2
chr10_108579917_108580068	0.68	SORCS1	sortilin-related VPS10 domain containing receptor 1	120876	0.06
chr9_3287483_3287783	0.67	RFX3	regulatory factor X, 3 (influences HLA class II expression)	16895	0.29
chr7_116073401_116073552	0.67	ENSG00000252672	.	208	0.94
chr9_127520364_127520515	0.67	RP11-175D17.3		11963	0.14
chr10_63734512_63734894	0.67	ENSG00000221272	.	47926	0.17
chr3_24544579_24544882	0.66	THRB	thyroid hormone receptor, beta	7957	0.19
chr6_124162652_124162803	0.66	RP11-374A22.1		18342	0.23
chr10_133761353_133761504	0.66	PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	7895	0.25
chr10_131681520_131681924	0.66	ENSG00000266676	.	40084	0.18
chr3_46028167_46028318	0.66	FYCO1	FYVE and coiled-coil domain containing 1	1755	0.35
chr1_208137980_208138131	0.65	CD34	CD34 molecule	53308	0.17
chr18_74193049_74193269	0.64	ZNF516	zinc finger protein 516	9576	0.17
chr17_79366105_79366434	0.64	RP11-1055B8.6	Uncharacterized protein	3006	0.16
chr9_113796923_113797156	0.64	LPAR1	lysophosphatidic acid receptor 1	3284	0.32
chr1_85064659_85064810	0.63	CTBS	chitobiase, di-N-acetyl-	24587	0.17
chr1_206846136_206846472	0.63	ENSG00000252853	.	9004	0.14
chr15_63270452_63270603	0.63	TPM1	tropomyosin 1 (alpha)	64304	0.1
chr2_217051631_217052157	0.62	AC012513.6		72424	0.09
chr11_43530345_43530496	0.61	ENSG00000211568	.	50786	0.12
chr15_67054534_67054685	0.61	SMAD6	SMAD family member 6	50574	0.15
chr20_4323404_4323681	0.61	ADRA1D	adrenoceptor alpha 1D	93821	0.08
chr21_40734712_40734961	0.61	HMGN1	high mobility group nucleosome binding domain 1	13263	0.12
chr12_77359039_77359190	0.61	E2F7	E2F transcription factor 7	85412	0.09
chr12_67753116_67753506	0.61	CAND1	cullin-associated and neddylation-dissociated 1	60559	0.16
chr3_189810552_189810703	0.61	ENSG00000265045	.	21096	0.16
chr15_74501500_74501755	0.60	STRA6	stimulated by retinoic acid 6	256	0.87
chr1_153669913_153670064	0.60	ENSG00000242565	.	6576	0.09
chr2_9027176_9027327	0.60	KIDINS220	kinase D-interacting substrate, 220kDa	49491	0.16
chr1_85797221_85797372	0.60	ENSG00000264380	.	47003	0.1
chr9_90169444_90169595	0.60	DAPK1-IT1	DAPK1 intronic transcript 1 (non-protein coding)	1150	0.6
chr1_163735603_163735754	0.59	ENSG00000212538	.	157229	0.04
chr16_78280255_78280779	0.59	RP11-190D6.2		5402	0.33
chr14_90950654_90950805	0.58	RP11-471B22.2		79150	0.08
chr8_125642230_125642584	0.58	RP11-532M24.1		50535	0.13
chr19_55106095_55106516	0.57	LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	1180	0.33
chrX_123342303_123342580	0.57	ENSG00000252693	.	10848	0.28
chr2_43300997_43301240	0.57	ENSG00000207087	.	17514	0.27
chr16_86785491_86785642	0.57	FOXL1	forkhead box L1	173451	0.03
chr22_24720862_24721013	0.56	SPECC1L	sperm antigen with calponin homology and coiled-coil domains 1-like	20573	0.18
chr11_73024899_73025487	0.56	ARHGEF17	Rho guanine nucleotide exchange factor (GEF) 17	2583	0.2
chr13_29064325_29064677	0.56	FLT1	fms-related tyrosine kinase 1	4731	0.33
chr4_169329476_169329627	0.56	DDX60L	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	7422	0.25
chrX_152064919_152065070	0.56	ZNF185	zinc finger protein 185 (LIM domain)	17992	0.16
chr3_194041385_194041965	0.56	CPN2	carboxypeptidase N, polypeptide 2	30372	0.17
chr16_66257397_66257680	0.56	ENSG00000201999	.	78174	0.1
chr6_37940843_37941265	0.55	ZFAND3	zinc finger, AN1-type domain 3	43319	0.17
chr6_145274519_145274670	0.55	UTRN	utrophin	154077	0.04
chr18_51766674_51767013	0.55	MBD2	methyl-CpG binding domain protein 2	15685	0.18
chr1_52630193_52630454	0.55	ENSG00000241745	.	14546	0.17
chr7_47523350_47523501	0.55	TNS3	tensin 3	2542	0.43
chr10_13815820_13815971	0.55	RP11-353M9.1		44512	0.11
chr14_33081374_33081525	0.55	AKAP6	A kinase (PRKA) anchor protein 6	117171	0.06
chr1_240263079_240263230	0.55	FMN2	formin 2	7974	0.26
chr15_32976727_32976921	0.54	RP11-1000B6.2		11558	0.16
chr3_159451540_159451691	0.54	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	29887	0.17
chr10_13022451_13022602	0.54	CCDC3	coiled-coil domain containing 3	21171	0.22
chr2_9425625_9425776	0.54	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	78806	0.1
chr12_15490373_15490524	0.54	RERG	RAS-like, estrogen-regulated, growth inhibitor	11084	0.24
chr14_73243285_73243436	0.54	ENSG00000206751	.	76679	0.1
chr2_43186157_43186340	0.54	ENSG00000207087	.	132384	0.05
chrX_109275317_109275479	0.54	ENSG00000208013	.	23159	0.19
chr10_5670699_5670850	0.53	ENSG00000240577	.	2652	0.26
chr3_171528829_171529427	0.53	PLD1	phospholipase D1, phosphatidylcholine-specific	844	0.52
chr3_129204995_129205146	0.53	IFT122	intraflagellar transport 122 homolog (Chlamydomonas)	1964	0.27
chr9_124154968_124155119	0.53	RP11-162D16.2		17524	0.16
chr16_51465265_51465416	0.52	ENSG00000223168	.	240134	0.02
chr16_85261165_85261449	0.52	CTC-786C10.1		56425	0.13
chr21_40683413_40684326	0.52	BRWD1	bromodomain and WD repeat domain containing 1	1627	0.24
chr9_119865830_119865981	0.52	ENSG00000265662	.	4619	0.3
chr7_81679057_81679208	0.52	MIR1255B1	microRNA 1255b-1	40624	0.18
chr1_61890145_61890308	0.52	NFIA	nuclear factor I/A	17882	0.29
chr1_64558521_64558672	0.52	RP11-24J23.2		19292	0.17
chr4_182889161_182889312	0.52	AC108142.1		117001	0.06
chr5_92868382_92868533	0.52	ENSG00000237187	.	38042	0.18
chr5_14397419_14397602	0.52	TRIO	trio Rho guanine nucleotide exchange factor	91047	0.1
chr5_33585033_33585326	0.51	TARS	threonyl-tRNA synthetase	143692	0.05
chr17_42185404_42185693	0.51	HDAC5	histone deacetylase 5	3161	0.13
chr18_47211525_47211994	0.51	LIPG	lipase, endothelial	123044	0.04
chr2_113597075_113597265	0.51	IL1B	interleukin 1, beta	2690	0.24
chr4_23882584_23882816	0.51	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	8958	0.3
chr6_139692314_139693115	0.51	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	2636	0.37
chr10_62722925_62723076	0.51	RHOBTB1	Rho-related BTB domain containing 1	18995	0.25
chr20_33166706_33166857	0.51	MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	20259	0.16
chr6_160562674_160562825	0.51	SLC22A1	solute carrier family 22 (organic cation transporter), member 1	11956	0.24
chr14_54466932_54467083	0.50	BMP4	bone morphogenetic protein 4	41528	0.19
chr8_59507297_59507555	0.50	SDCBP	syndecan binding protein (syntenin)	29851	0.19
chrX_102195495_102195646	0.50	LL0XNC01-237H1.3		81	0.97
chr22_36862902_36863319	0.50	TXN2	thioredoxin 2	14277	0.14
chr7_151396712_151396968	0.50	PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	36509	0.18
chr1_218671039_218671190	0.50	C1orf143	chromosome 1 open reading frame 143	12324	0.25
chr1_246317345_246317496	0.50	ENSG00000202184	.	35000	0.16
chr18_45968056_45968207	0.50	ZBTB7C	zinc finger and BTB domain containing 7C	31008	0.17
chr1_17938345_17938496	0.50	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like	6391	0.29
chr2_37614586_37614737	0.50	QPCT	glutaminyl-peptide cyclotransferase	19237	0.18
chr17_48104312_48105191	0.50	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	28588	0.11
chr1_195877737_195877888	0.49	ENSG00000265986	.	673799	0.0
chr22_50735808_50736190	0.49	PLXNB2	plexin B2	3892	0.11
chr9_118789474_118789768	0.49	PAPPA	pregnancy-associated plasma protein A, pappalysin 1	126462	0.06
chr8_28564957_28565108	0.49	EXTL3	exostosin-like glycosyltransferase 3	2843	0.26
chr15_35346199_35346350	0.48	ZNF770	zinc finger protein 770	65786	0.12
chr6_106251962_106252192	0.48	ENSG00000200198	.	100171	0.08
chr10_29977031_29977695	0.48	ENSG00000222092	.	23481	0.21
chr15_39416646_39416797	0.48	RP11-624L4.1		5807	0.33
chr3_65930585_65930845	0.48	ENSG00000264716	.	3793	0.23
chr20_43881669_43881820	0.48	SLPI	secretory leukocyte peptidase inhibitor	1461	0.32
chr1_44503070_44503221	0.48	SLC6A9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	6011	0.16
chr6_138095492_138095643	0.48	ENSG00000207300	.	9944	0.23
chr8_20152921_20153072	0.48	ENSG00000253733	.	5311	0.23
chr6_159158703_159158854	0.48	ENSG00000265558	.	27007	0.17
chr1_32172423_32172595	0.48	COL16A1	collagen, type XVI, alpha 1	2589	0.22
chr14_23549622_23550020	0.47	ACIN1	apoptotic chromatin condensation inducer 1	8995	0.09
chr1_54163188_54163339	0.47	ENSG00000239007	.	8778	0.21
chr7_27150973_27151370	0.47	HOXA3	homeobox A3	2293	0.11
chr15_35598050_35598318	0.47	ENSG00000265102	.	66381	0.14
chr3_171792488_171792655	0.47	FNDC3B	fibronectin type III domain containing 3B	27868	0.24
chr9_16501412_16501563	0.47	RP11-183I6.2		28301	0.22
chr8_98941895_98942046	0.47	MATN2	matrilin 2	1599	0.45
chr2_114170315_114170581	0.47	IGKV1OR2-108	immunoglobulin kappa variable 1/OR2-108 (non-functional)	6285	0.16
chr2_102730194_102730345	0.46	IL1R1	interleukin 1 receptor, type I	9240	0.24
chr7_24962654_24962846	0.46	OSBPL3	oxysterol binding protein-like 3	5038	0.27
chr9_110804150_110804301	0.46	ENSG00000222459	.	122966	0.06
chr6_11213119_11213404	0.46	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	19630	0.2
chr9_113637188_113637339	0.46	ENSG00000206923	.	28354	0.2
chr2_27301986_27302370	0.46	EMILIN1	elastin microfibril interfacer 1	743	0.39
chr9_89810062_89810213	0.46	C9orf170	chromosome 9 open reading frame 170	46578	0.18
chr11_57057514_57057665	0.46	TNKS1BP1	tankyrase 1 binding protein 1, 182kDa	32082	0.09
chr5_171272261_171272412	0.46	SMIM23	small integral membrane protein 23	59446	0.12
chr14_55137351_55137502	0.46	SAMD4A	sterile alpha motif domain containing 4A	84125	0.09
chr15_77707876_77708432	0.46	PEAK1	pseudopodium-enriched atypical kinase 1	4288	0.26
chr1_59780923_59781074	0.46	FGGY	FGGY carbohydrate kinase domain containing	5239	0.35
chr6_73359022_73359317	0.46	KCNQ5-IT1	KCNQ5 intronic transcript 1 (non-protein coding)	18946	0.23
chr6_170713316_170713467	0.46	RP1-140C12.2		9836	0.24
chr1_226285928_226286144	0.45	H3F3A	H3 histone, family 3A	34358	0.13
chr9_36789617_36789768	0.45	ENSG00000266255	.	33904	0.18
chr18_74209147_74209298	0.45	RP11-17M16.1	uncharacterized protein LOC400658	1745	0.29
chr8_37404346_37404744	0.45	RP11-150O12.6		30006	0.2

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA2_HOXB1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.4	GO:0033591	response to L-ascorbic acid(GO:0033591)
0.1	0.3	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.1	0.3	GO:0035609	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.1	0.6	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1	0.3	GO:0071731	response to nitric oxide(GO:0071731)
0.1	0.2	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.1	0.3	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.1	0.2	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.1	0.2	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.1	0.2	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.1	0.2	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.2	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0032347	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.2	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0072179	nephric duct formation(GO:0072179)
0.0	0.1	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.1	GO:0060462	lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.0	0.1	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0	0.1	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.3	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.2	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.0	GO:0031392	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.2	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.2	GO:0060174	limb bud formation(GO:0060174)
0.0	0.2	GO:0045634	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.7	GO:0002040	sprouting angiogenesis(GO:0002040)
0.0	0.1	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.2	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	1.1	GO:0046847	filopodium assembly(GO:0046847)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0048752	semicircular canal morphogenesis(GO:0048752)
0.0	0.1	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.1	GO:0021569	rhombomere 3 development(GO:0021569)
0.0	0.1	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.4	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0019532	oxalate transport(GO:0019532)
0.0	0.0	GO:0045628	regulation of T-helper 2 cell differentiation(GO:0045628)
0.0	0.1	GO:0042109	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.1	GO:0060754	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.0	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.3	GO:0007567	parturition(GO:0007567)
0.0	0.1	GO:0002002	regulation of angiotensin levels in blood(GO:0002002)
0.0	0.1	GO:0003321	positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.2	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.2	GO:0090114	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.0	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.5	GO:0050873	brown fat cell differentiation(GO:0050873)
0.0	0.1	GO:0046902	regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559)
0.0	0.4	GO:0048286	lung alveolus development(GO:0048286)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.0	GO:0019859	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:0014832	urinary bladder smooth muscle contraction(GO:0014832)
0.0	0.2	GO:0060438	trachea development(GO:0060438)
0.0	0.3	GO:0010171	body morphogenesis(GO:0010171)
0.0	0.2	GO:0060487	lung cell differentiation(GO:0060479) lung epithelial cell differentiation(GO:0060487)
0.0	0.1	GO:0001553	luteinization(GO:0001553)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.0	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.1	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.1	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.1	GO:0002832	negative regulation of response to biotic stimulus(GO:0002832) negative regulation of defense response to virus(GO:0050687)
0.0	0.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0016199	axon midline choice point recognition(GO:0016199)
0.0	0.1	GO:0060017	parathyroid gland development(GO:0060017)
0.0	0.1	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.0	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0035058	nonmotile primary cilium assembly(GO:0035058)
0.0	0.1	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.0	GO:1901976	regulation of cell cycle checkpoint(GO:1901976)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0007289	spermatid nucleus differentiation(GO:0007289)
0.0	0.1	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.1	GO:0015904	tetracycline transport(GO:0015904) antibiotic transport(GO:0042891) toxin transport(GO:1901998)
0.0	0.1	GO:0034405	response to fluid shear stress(GO:0034405)
0.0	0.0	GO:0090382	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.0	GO:0060492	foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:2000644	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.0	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.0	0.1	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0042448	progesterone metabolic process(GO:0042448)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.1	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.1	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.0	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.0	GO:1903115	regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0	0.0	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.0	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.2	GO:0001502	cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0	0.1	GO:0030825	positive regulation of cGMP metabolic process(GO:0030825)
0.0	0.2	GO:0015695	organic cation transport(GO:0015695)
0.0	0.2	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0006896	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.1	GO:0060027	convergent extension involved in gastrulation(GO:0060027)
0.0	0.0	GO:0036315	cellular response to sterol(GO:0036315) cellular response to cholesterol(GO:0071397)
0.0	0.1	GO:0032515	negative regulation of phosphatase activity(GO:0010923) negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0090085	regulation of protein deubiquitination(GO:0090085)
0.0	0.0	GO:0050965	detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0	0.0	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0	0.1	GO:1901532	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.2	GO:0006893	Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0	0.0	GO:0060406	regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406)
0.0	0.0	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.0	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.1	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.0	GO:0097300	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.0	GO:0045332	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.1	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.0	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.1	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.0	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.0	0.4	GO:0001843	neural tube closure(GO:0001843) tube closure(GO:0060606)
0.0	0.1	GO:0032981	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	0.1	GO:0045075	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0	0.0	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.1	GO:0035092	sperm chromatin condensation(GO:0035092)
0.0	0.1	GO:0006734	NADH metabolic process(GO:0006734)
0.0	0.0	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0071479	cellular response to ionizing radiation(GO:0071479)
0.0	0.1	GO:0090026	regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0	0.0	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.0	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.1	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089) positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.0	0.0	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0071320	cellular response to cAMP(GO:0071320)
0.0	0.6	GO:0007229	integrin-mediated signaling pathway(GO:0007229)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0006385	transcription elongation from RNA polymerase III promoter(GO:0006385) termination of RNA polymerase III transcription(GO:0006386)
0.0	0.0	GO:0097094	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.0	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.0	GO:0010658	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.0	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.0	GO:0035283	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.0	GO:0002320	lymphoid progenitor cell differentiation(GO:0002320)
0.0	0.1	GO:0001974	blood vessel remodeling(GO:0001974)
0.0	0.0	GO:1902745	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.3	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.1	GO:0007263	nitric oxide mediated signal transduction(GO:0007263)
0.0	0.0	GO:0046639	negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0	0.0	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin(GO:0001991)
0.0	0.0	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:0003151	outflow tract morphogenesis(GO:0003151)
0.0	0.2	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.0	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.0	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.1	GO:0007076	mitotic chromosome condensation(GO:0007076)
0.0	0.1	GO:0006266	DNA ligation(GO:0006266)
0.0	0.0	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.3	GO:0022405	hair follicle development(GO:0001942) molting cycle process(GO:0022404) hair cycle process(GO:0022405) skin epidermis development(GO:0098773)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.1	GO:0046037	GMP metabolic process(GO:0046037)
0.0	0.1	GO:0006700	C21-steroid hormone biosynthetic process(GO:0006700)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.0	GO:0042693	muscle cell fate commitment(GO:0042693)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:0010713	negative regulation of collagen metabolic process(GO:0010713) negative regulation of multicellular organismal metabolic process(GO:0044252)
0.0	0.0	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0043259	laminin-10 complex(GO:0043259)
0.1	0.2	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	0.2	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.2	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.2	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.2	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.3	GO:0043205	fibril(GO:0043205)
0.0	0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.2	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.7	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	0.1	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.3	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0042599	lamellar body(GO:0042599)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.0	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.1	GO:0001520	outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0	0.2	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.2	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0098651	basement membrane collagen trimer(GO:0098651)
0.0	1.5	GO:0030027	lamellipodium(GO:0030027)
0.0	0.2	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.3	GO:0005771	multivesicular body(GO:0005771)
0.0	0.1	GO:0031083	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.0	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.3	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	0.2	GO:0000421	autophagosome membrane(GO:0000421)
0.0	1.3	GO:0005925	focal adhesion(GO:0005925)
0.0	0.3	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.1	GO:0034704	calcium channel complex(GO:0034704)
0.0	0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.5	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.1	GO:0005593	FACIT collagen trimer(GO:0005593)
0.0	0.0	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.3	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0	0.0	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.4	GO:0030018	Z disc(GO:0030018)
0.0	0.1	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0002102	podosome(GO:0002102)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.1	0.3	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.1	0.3	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.1	0.2	GO:0050693	LBD domain binding(GO:0050693)
0.1	0.2	GO:0000987	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.2	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.1	0.2	GO:1901474	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.1	0.3	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1	0.3	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.1	0.3	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.3	GO:0070513	death domain binding(GO:0070513)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.2	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.2	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.3	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.2	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.5	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.2	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0031544	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.2	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.2	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.1	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.2	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.2	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.0	GO:0033612	receptor serine/threonine kinase binding(GO:0033612)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.2	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.1	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0	0.1	GO:0034416	bisphosphoglycerate phosphatase activity(GO:0034416)
0.0	0.1	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.4	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.2	GO:0048185	activin binding(GO:0048185)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0	0.3	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.2	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.1	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.2	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.4	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.0	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0	0.1	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.2	GO:0015101	organic cation transmembrane transporter activity(GO:0015101)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.0	GO:0048039	ubiquinone binding(GO:0048039)
0.0	0.1	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.0	GO:0015421	oligopeptide-transporting ATPase activity(GO:0015421)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.2	GO:0004522	ribonuclease A activity(GO:0004522)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.1	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.4	GO:0003823	antigen binding(GO:0003823)
0.0	0.0	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.0	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.3	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.0	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0042301	phosphate ion binding(GO:0042301)
0.0	0.0	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	1.0	GO:0005088	Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0	0.0	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.0	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.0	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.0	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.0	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.0	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.0	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.5	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0	0.3	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.0	0.1	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.0	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.0	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0	0.0	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.0	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.0	GO:0031014	troponin T binding(GO:0031014)
0.0	0.1	GO:0016500	protein-hormone receptor activity(GO:0016500)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	PID ALK2 PATHWAY	ALK2 signaling events
0.1	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.3	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.6	PID S1P S1P2 PATHWAY	S1P2 pathway
0.3	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
1.0	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.7	PID BMP PATHWAY	BMP receptor signaling
0.5	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.5	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.1	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.5	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.3	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.3	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.4	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.4	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	REACTOME HEMOSTASIS	Genes involved in Hemostasis
0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.3	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.2	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	Genes involved in Insulin receptor signalling cascade
0.0	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.0	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.3	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.4	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.2	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.3	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.0	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	REACTOME INTEGRATION OF ENERGY METABOLISM	Genes involved in Integration of energy metabolism
0.1	REACTOME GABA B RECEPTOR ACTIVATION	Genes involved in GABA B receptor activation
0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.1	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.3	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.1	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors

Results for HOXA2_HOXB1

Z-value: 2.07

Motif logo

Transcription factors associated with HOXA2_HOXB1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the HOXA2_HOXB1 motif across conditions

Conditions sorted by the z-value of the HOXA2_HOXB1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA2_HOXB1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: