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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HOXB3

Z-value: 1.50

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Transcription factors associated with HOXB3

Gene Symbol	Gene ID	Gene Info
HOXB3 Ensembl NCBI GeneCards UniProt	ENSG00000120093.7	HOXB3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HOXB3	chr17_46654451_46654696	2135	0.116487	-0.84	4.5e-03	Click!
HOXB3	chr17_46632798_46632949	1010	0.266210	-0.84	4.9e-03	Click!
HOXB3	chr17_46655643_46655794	1001	0.238854	-0.83	5.8e-03	Click!
HOXB3	chr17_46662373_46662833	2619	0.098821	-0.82	7.1e-03	Click!
HOXB3	chr17_46654100_46654251	1737	0.143918	-0.80	9.0e-03	Click!

Activity of the HOXB3 motif across conditions

Conditions sorted by the z-value of the HOXB3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_51051372_51051556	0.51	ENSG00000221198	.	114091	0.07
chr17_66379311_66379462	0.47	ENSG00000207561	.	41303	0.14
chr15_39652479_39652630	0.47	RP11-624L4.1		60356	0.14
chr10_89436229_89436444	0.45	PAPSS2	3'-phosphoadenosine 5'-phosphosulfate synthase 2	15628	0.19
chr7_150784838_150785537	0.42	AGAP3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	1033	0.32
chr9_3360340_3360491	0.40	RFX3	regulatory factor X, 3 (influences HLA class II expression)	13651	0.3
chr15_50194108_50194259	0.40	ATP8B4	ATPase, class I, type 8B, member 4	6107	0.24
chr10_30347671_30348341	0.38	KIAA1462	KIAA1462	447	0.9
chr7_133267178_133267329	0.37	EXOC4	exocyst complex component 4	6037	0.35
chr4_89647157_89647308	0.37	FAM13A-AS1	FAM13A antisense RNA 1	4366	0.21
chrX_39832066_39832217	0.37	BCOR	BCL6 corepressor	90049	0.09
chr8_29057628_29057779	0.36	ENSG00000264328	.	57493	0.09
chr12_62931646_62931797	0.36	ENSG00000202034	.	7738	0.19
chr12_12016346_12017014	0.35	ETV6	ets variant 6	22191	0.26
chr1_64549059_64549210	0.34	ENSG00000200508	.	16721	0.18
chr6_97629282_97629433	0.33	MMS22L	MMS22-like, DNA repair protein	81871	0.11
chr9_88955484_88955635	0.33	ZCCHC6	zinc finger, CCHC domain containing 6	2479	0.34
chr12_81338456_81338607	0.32	LIN7A	lin-7 homolog A (C. elegans)	6827	0.19
chr2_33662966_33663243	0.32	RASGRP3	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	1713	0.48
chr20_43124845_43125142	0.32	SERINC3	serine incorporator 3	8539	0.13
chrX_37702580_37702731	0.32	DYNLT3	dynein, light chain, Tctex-type 3	4006	0.26
chr1_97899901_97900052	0.32	DPYD-IT1	DPYD intronic transcript 1 (non-protein coding)	14279	0.31
chr11_71524282_71524863	0.32	ZNF705E	zinc finger protein 705E	6261	0.1
chr17_66380501_66380857	0.31	ENSG00000207561	.	40010	0.14
chr2_28344167_28344318	0.31	ENSG00000265321	.	125008	0.05
chr6_134871939_134872090	0.31	SGK1	serum/glucocorticoid regulated kinase 1	232764	0.02
chr16_87840292_87840843	0.31	RP4-536B24.2		29571	0.14
chr6_39787204_39787470	0.30	DAAM2	dishevelled associated activator of morphogenesis 2	26543	0.21
chr8_80226395_80226546	0.30	ENSG00000264969	.	216872	0.02
chr2_118804547_118804712	0.30	ENSG00000243510	.	30671	0.13
chr2_223875941_223876092	0.30	KCNE4	potassium voltage-gated channel, Isk-related family, member 4	40516	0.17
chr11_6376113_6376264	0.30	PRKCDBP	protein kinase C, delta binding protein	34311	0.11
chr8_101294374_101294525	0.29	RNF19A	ring finger protein 19A, RBR E3 ubiquitin protein ligase	21009	0.2
chr1_36908138_36908289	0.29	OSCP1	organic solute carrier partner 1	1637	0.28
chr5_5374817_5374968	0.29	KIAA0947	KIAA0947	47915	0.19
chr7_39480916_39481067	0.29	POU6F2-AS1	POU6F2 antisense RNA 1	35046	0.19
chr2_153267355_153267720	0.29	FMNL2	formin-like 2	75786	0.12
chr2_145225492_145225643	0.29	ZEB2	zinc finger E-box binding homeobox 2	37430	0.19
chr2_33501178_33501329	0.29	LTBP1	latent transforming growth factor beta binding protein 1	277	0.93
chr2_189847314_189847465	0.28	ENSG00000221502	.	4571	0.25
chr16_17931428_17931579	0.28	XYLT1	xylosyltransferase I	366765	0.01
chr1_92207941_92208092	0.28	ENSG00000239794	.	87615	0.09
chr7_15498785_15499062	0.28	AGMO	alkylglycerol monooxygenase	93076	0.1
chr1_44412862_44413792	0.28	IPO13	importin 13	716	0.44
chr15_79204771_79204922	0.28	ENSG00000252061	.	13568	0.17
chr10_94452668_94452819	0.28	HHEX	hematopoietically expressed homeobox	1131	0.51
chr6_107645107_107645353	0.27	PDSS2	prenyl (decaprenyl) diphosphate synthase, subunit 2	111867	0.06
chr15_71824033_71824261	0.27	THSD4	thrombospondin, type I, domain containing 4	15428	0.25
chr4_25407599_25407888	0.27	ANAPC4	anaphase promoting complex subunit 4	28801	0.19
chr15_93579557_93579854	0.27	CHD2	chromodomain helicase DNA binding protein 2	27609	0.2
chr3_156975213_156975364	0.27	ENSG00000243176	.	27220	0.2
chr3_197784203_197784354	0.27	ENSG00000212297	.	14010	0.14
chr3_14418133_14418284	0.27	ENSG00000199609	.	17940	0.21
chr5_36300489_36300640	0.27	RANBP3L	RAN binding protein 3-like	1438	0.48
chr9_3768105_3768256	0.27	RP11-252M18.3		107404	0.07
chr5_57006064_57006215	0.27	ENSG00000221195	.	67326	0.13
chr1_185390714_185391145	0.26	ENSG00000252407	.	12447	0.26
chr9_128640336_128640592	0.26	PBX3	pre-B-cell leukemia homeobox 3	12914	0.3
chr2_119427478_119427629	0.26	EN1	engrailed homeobox 1	177701	0.03
chr7_116218439_116218590	0.26	AC006159.4		7226	0.19
chr2_190018216_190018510	0.26	ENSG00000264725	.	20526	0.19
chr18_56240273_56240424	0.26	RP11-126O1.2		16046	0.15
chr13_115076948_115077099	0.26	CHAMP1	chromosome alignment maintaining phosphoprotein 1	2965	0.23
chr5_38924606_38924757	0.26	OSMR	oncostatin M receptor	20181	0.26
chr8_69903972_69904123	0.26	ENSG00000238808	.	118762	0.07
chr8_19516504_19516655	0.26	CSGALNACT1	chondroitin sulfate N-acetylgalactosaminyltransferase 1	23515	0.27
chr1_90290727_90290878	0.25	LRRC8D	leucine rich repeat containing 8 family, member D	3322	0.28
chr3_29228707_29228858	0.25	RBMS3	RNA binding motif, single stranded interacting protein 3	93691	0.09
chr14_82456075_82456226	0.25	SEL1L	sel-1 suppressor of lin-12-like (C. elegans)	455945	0.01
chr22_46426709_46426860	0.25	RP6-109B7.5		22189	0.1
chr4_119732850_119733001	0.25	SEC24D	SEC24 family member D	24368	0.24
chr9_80524258_80524409	0.25	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	86418	0.1
chr12_110388287_110388838	0.25	GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	45467	0.11
chr10_74248398_74248549	0.25	RP11-167P22.3		13031	0.19
chr12_7596689_7596840	0.25	CD163L1	CD163 molecule-like 1	15	0.98
chr4_40375661_40375812	0.25	ENSG00000239010	.	3794	0.24
chr14_101308246_101309004	0.25	ENSG00000214548	.	7020	0.04
chr17_66379496_66379718	0.25	ENSG00000207561	.	41082	0.14
chr5_36928360_36928511	0.24	NIPBL	Nipped-B homolog (Drosophila)	51543	0.18
chr1_52043843_52044143	0.24	OSBPL9	oxysterol binding protein-like 9	1142	0.5
chr14_100240950_100241315	0.24	EML1	echinoderm microtubule associated protein like 1	1091	0.59
chr5_169308984_169309135	0.24	FAM196B	family with sequence similarity 196, member B	98685	0.07
chr12_1727335_1727720	0.24	WNT5B	wingless-type MMTV integration site family, member 5B	1305	0.46
chr5_138288736_138289663	0.24	CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	22872	0.17
chr10_75798433_75798584	0.24	RP11-417O11.5		33613	0.15
chr11_19619185_19619336	0.24	ENSG00000207407	.	6422	0.22
chr3_173610727_173610878	0.24	NLGN1-AS1	NLGN1 antisense RNA 1	27646	0.27
chr5_90592330_90592999	0.24	ENSG00000199643	.	26120	0.23
chr9_113926997_113927193	0.24	ENSG00000212409	.	67402	0.12
chr1_56098686_56098837	0.24	ENSG00000272051	.	148116	0.04
chr2_118817741_118818188	0.24	INSIG2	insulin induced gene 2	28086	0.15
chr11_63278500_63278680	0.24	LGALS12	lectin, galactoside-binding, soluble, 12	3131	0.21
chr12_105617824_105617982	0.24	APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	5735	0.25
chr11_34338329_34338672	0.24	ABTB2	ankyrin repeat and BTB (POZ) domain containing 2	40302	0.19
chr14_74724538_74725207	0.24	VSX2	visual system homeobox 2	18697	0.14
chr7_101457741_101458764	0.24	CUX1	cut-like homeobox 1	707	0.73
chr2_8012045_8012196	0.24	ENSG00000221255	.	295148	0.01
chr15_70023529_70023680	0.24	ENSG00000238870	.	443	0.88
chr2_158326449_158327167	0.24	CYTIP	cytohesin 1 interacting protein	18533	0.22
chr8_13078515_13078765	0.23	DLC1	deleted in liver cancer 1	55415	0.14
chr12_43709526_43709677	0.23	ENSG00000215993	.	24218	0.27
chr11_109453346_109453497	0.23	RP11-708B6.2		948	0.73
chr15_57527692_57527843	0.23	TCF12	transcription factor 12	12447	0.25
chr1_109740426_109740857	0.23	ENSG00000238310	.	9829	0.15
chr5_52192649_52192800	0.23	ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	92432	0.07
chr11_12436390_12436541	0.23	PARVA	parvin, alpha	16677	0.24
chr11_121979710_121979861	0.23	RP11-166D19.1		3135	0.2
chr11_103924198_103924349	0.23	PDGFD	platelet derived growth factor D	16519	0.22
chr2_238221351_238221502	0.23	AC112715.2	Uncharacterized protein	55692	0.13
chr4_86718935_86719260	0.23	ARHGAP24	Rho GTPase activating protein 24	19238	0.25
chr4_26346811_26346962	0.23	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	2124	0.47
chr4_169768965_169769116	0.23	RP11-635L1.3		14952	0.19
chr15_65851048_65851199	0.23	ENSG00000207449	.	5598	0.14
chr4_77680501_77680652	0.23	RP11-359D14.2		949	0.62
chr17_3705503_3705718	0.23	ITGAE	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	1073	0.45
chr9_90131509_90131738	0.23	DAPK1	death-associated protein kinase 1	17703	0.23
chr2_36720605_36720756	0.23	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	20153	0.19
chr2_147081299_147081450	0.23	ENSG00000251905	.	178650	0.04
chr12_52585492_52585885	0.23	KRT80	keratin 80	96	0.95
chr7_37011204_37011355	0.23	ELMO1	engulfment and cell motility 1	13386	0.2
chr9_112955106_112955494	0.23	C9orf152	chromosome 9 open reading frame 152	15169	0.23
chr1_161691025_161691176	0.23	FCRLB	Fc receptor-like B	253	0.86
chr13_24862558_24862709	0.23	SPATA13	spermatogenesis associated 13	15806	0.14
chr2_62987338_62987489	0.23	ENSG00000252436	.	33538	0.18
chr11_71778137_71778288	0.23	NUMA1	nuclear mitotic apparatus protein 1	2921	0.12
chr2_145785636_145785787	0.23	ENSG00000253036	.	306927	0.01
chr7_28104329_28104480	0.23	JAZF1	JAZF zinc finger 1	6899	0.27
chr2_841280_841431	0.23	AC113607.3		75455	0.1
chr1_184026988_184027139	0.23	TSEN15	TSEN15 tRNA splicing endonuclease subunit	6183	0.25
chr2_145135123_145135336	0.23	GTDC1	glycosyltransferase-like domain containing 1	45146	0.17
chr12_10194519_10194670	0.23	CLEC9A	C-type lectin domain family 9, member A	11318	0.12
chr13_114871936_114872087	0.23	RASA3-IT1	RASA3 intronic transcript 1 (non-protein coding)	2284	0.35
chr15_50148578_50148980	0.22	ATP8B4	ATPase, class I, type 8B, member 4	20113	0.21
chrX_121759874_121760025	0.22	ENSG00000221317	.	154278	0.04
chr2_52146184_52146335	0.22	ENSG00000202195	.	378874	0.01
chr13_21289490_21289641	0.22	ENSG00000265710	.	11723	0.19
chr4_122569979_122570130	0.22	ANXA5	annexin A5	48063	0.16
chr13_77971472_77971623	0.22	MYCBP2	MYC binding protein 2, E3 ubiquitin protein ligase	70368	0.12
chr6_11590032_11590183	0.22	TMEM170B	transmembrane protein 170B	51596	0.15
chr11_101316311_101316462	0.22	ENSG00000263885	.	74250	0.12
chr12_89453867_89454269	0.22	ENSG00000238302	.	221994	0.02
chr21_40856650_40856801	0.22	SH3BGR	SH3 domain binding glutamic acid-rich protein	15024	0.18
chr8_57425756_57425907	0.22	RP11-17A4.2		24174	0.24
chr15_29022183_29022334	0.22	RP11-578F21.10		11490	0.15
chr3_151082583_151082734	0.22	P2RY12	purinergic receptor P2Y, G-protein coupled, 12	19942	0.17
chr20_48295346_48295512	0.22	B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	34986	0.15
chr3_159740833_159741097	0.22	LINC01100	long intergenic non-protein coding RNA 1100	7154	0.2
chr2_238442752_238442903	0.22	MLPH	melanophilin	6681	0.17
chr4_148710085_148710236	0.22	ENSG00000264274	.	6414	0.2
chr8_134591977_134592128	0.22	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	7869	0.3
chr5_31990290_31990441	0.22	ENSG00000266243	.	54100	0.13
chr2_36731284_36731435	0.22	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	9474	0.2
chr9_138952025_138952443	0.22	NACC2	NACC family member 2, BEN and BTB (POZ) domain containing	9808	0.22
chr2_200180531_200180682	0.22	RP11-486F17.1		9427	0.3
chr5_90603533_90603789	0.22	ENSG00000199643	.	37117	0.18
chr3_148722415_148722820	0.22	GYG1	glycogenin 1	12459	0.19
chr11_92117975_92118126	0.22	RP11-675M1.2		23292	0.23
chr8_16535817_16535968	0.22	MSR1	macrophage scavenger receptor 1	111021	0.07
chr16_68100077_68100483	0.22	ENSG00000221789	.	10493	0.1
chr14_32977387_32977538	0.22	AKAP6	A kinase (PRKA) anchor protein 6	13184	0.26
chr15_56269998_56270149	0.22	NEDD4	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	15871	0.2
chr1_10303434_10303585	0.22	KIF1B	kinesin family member 1B	11201	0.16
chr10_4426416_4426567	0.22	ENSG00000207124	.	130653	0.06
chr10_31272970_31273270	0.22	ZNF438	zinc finger protein 438	235	0.96
chr4_54870791_54871088	0.22	AC110792.1	HCG2027126; Uncharacterized protein	56274	0.12
chr15_63739639_63739912	0.22	USP3	ubiquitin specific peptidase 3	57018	0.12
chr4_81228983_81229134	0.22	C4orf22	chromosome 4 open reading frame 22	27816	0.2
chr2_158113855_158114082	0.22	GALNT5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	142	0.97
chr11_122129149_122129397	0.22	RP11-716H6.2		36625	0.18
chr3_153331537_153331688	0.22	ENSG00000200162	.	6446	0.31
chr2_198094184_198094335	0.22	ANKRD44	ankyrin repeat domain 44	31497	0.16
chr4_138463404_138463555	0.22	PCDH18	protocadherin 18	9831	0.33
chr2_64515406_64515557	0.21	ENSG00000264297	.	52412	0.14
chr6_125541820_125541971	0.21	TPD52L1	tumor protein D52-like 1	904	0.71
chr3_81913343_81913495	0.21	GBE1	glucan (1,4-alpha-), branching enzyme 1	102107	0.09
chr10_17151320_17151471	0.21	CUBN	cubilin (intrinsic factor-cobalamin receptor)	18441	0.23
chr5_71501439_71501590	0.21	MAP1B	microtubule-associated protein 1B	26059	0.19
chr16_70057514_70057665	0.21	ENSG00000239118	.	6660	0.16
chr7_55491154_55491305	0.21	LANCL2	LanC lantibiotic synthetase component C-like 2 (bacterial)	58088	0.14
chr3_108988791_108989046	0.21	ENSG00000252889	.	44942	0.15
chr6_52430093_52430244	0.21	TRAM2	translocation associated membrane protein 2	11545	0.25
chr1_78841651_78841802	0.21	ENSG00000212308	.	773	0.75
chr3_145791643_145791794	0.21	RP11-274H2.3		4746	0.16
chr13_73379676_73380042	0.21	DIS3	DIS3 mitotic control homolog (S. cerevisiae)	23625	0.15
chr6_64389523_64389709	0.21	PHF3	PHD finger protein 3	30	0.99
chr4_178223159_178223383	0.21	NEIL3	nei endonuclease VIII-like 3 (E. coli)	7719	0.23
chr6_13437908_13438059	0.21	GFOD1	glucose-fructose oxidoreductase domain containing 1	29614	0.15
chr3_112329096_112329326	0.21	CCDC80	coiled-coil domain containing 80	84	0.98
chr15_38437640_38437791	0.21	SPRED1	sprouty-related, EVH1 domain containing 1	106812	0.08
chr2_169772940_169773098	0.21	SPC25	SPC25, NDC80 kinetochore complex component	3232	0.28
chr18_21470429_21470580	0.21	ENSG00000221389	.	3666	0.25
chr17_68163620_68163771	0.21	KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	1119	0.45
chr3_183173438_183173589	0.21	ENSG00000251730	.	1597	0.22
chr10_100288310_100288461	0.21	HPS1	Hermansky-Pudlak syndrome 1	81702	0.09
chr2_9292545_9292696	0.21	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	54274	0.16
chr4_16771566_16771717	0.21	LDB2	LIM domain binding 2	95705	0.09
chr21_35908494_35908645	0.21	RCAN1	regulator of calcineurin 1	9308	0.2
chr5_35771841_35771992	0.21	SPEF2	sperm flagellar 2	7354	0.25
chr7_81405925_81406300	0.21	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	6358	0.33
chr8_90731390_90731592	0.21	RIPK2	receptor-interacting serine-threonine kinase 2	38484	0.22

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.3	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.2	GO:0007132	meiotic metaphase I(GO:0007132)
0.1	0.2	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.2	GO:0071436	sodium ion export(GO:0071436)
0.1	0.1	GO:0021825	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.1	0.3	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1	0.2	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.1	0.2	GO:0002328	pro-B cell differentiation(GO:0002328)
0.1	0.2	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1	0.2	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1	0.3	GO:0016322	neuron remodeling(GO:0016322)
0.1	0.2	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.1	0.3	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.1	0.3	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.1	0.2	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.1	GO:0070828	heterochromatin assembly(GO:0031507) heterochromatin organization(GO:0070828)
0.0	0.2	GO:0061001	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.2	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.2	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	1.1	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.3	GO:0006896	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.2	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.2	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.1	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.2	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0022030	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.2	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.0	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.8	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.1	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.1	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0002870	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.1	GO:2001279	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.1	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.1	GO:0090030	regulation of steroid hormone biosynthetic process(GO:0090030)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414)
0.0	0.1	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.0	GO:0003283	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0060760	positive regulation of response to cytokine stimulus(GO:0060760)
0.0	0.1	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.1	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.1	GO:0001779	natural killer cell differentiation(GO:0001779)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.1	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.1	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.1	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.0	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.1	GO:0016115	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.1	GO:0060754	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0032933	SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.3	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.1	GO:0021800	cerebral cortex tangential migration(GO:0021800)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.0	GO:0002885	positive regulation of hypersensitivity(GO:0002885)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0042504	tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519) positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520)
0.0	0.0	GO:0044321	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.0	GO:0009125	nucleoside monophosphate catabolic process(GO:0009125)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.3	GO:0006195	purine nucleotide catabolic process(GO:0006195)
0.0	0.2	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.1	GO:0071347	cellular response to interleukin-1(GO:0071347)
0.0	0.1	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.0	0.1	GO:0021508	floor plate formation(GO:0021508)
0.0	0.0	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0070528	protein kinase C signaling(GO:0070528)
0.0	0.0	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.0	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.0	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.0	GO:0048631	regulation of skeletal muscle tissue growth(GO:0048631)
0.0	0.1	GO:0031033	myosin filament organization(GO:0031033)
0.0	0.1	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.2	GO:0010458	exit from mitosis(GO:0010458)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.0	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:0032354	response to follicle-stimulating hormone(GO:0032354)
0.0	0.0	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.0	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.1	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.0	GO:0051459	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.0	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.0	GO:0032817	regulation of natural killer cell proliferation(GO:0032817)
0.0	0.1	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0	0.0	GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus(GO:0002866)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.0	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.1	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.0	0.0	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.0	GO:0009261	ribonucleotide catabolic process(GO:0009261)
0.0	0.0	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.0	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.0	GO:0045915	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0	0.1	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.0	0.0	GO:0030540	female genitalia development(GO:0030540)
0.0	0.0	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.1	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.1	GO:0070207	protein homotrimerization(GO:0070207)
0.0	0.0	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.0	GO:0021591	ventricular system development(GO:0021591)
0.0	0.0	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.0	GO:2000189	regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.0	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.0	GO:0034371	chylomicron remodeling(GO:0034371)
0.0	0.1	GO:0044245	polysaccharide digestion(GO:0044245)
0.0	0.0	GO:0071731	response to nitric oxide(GO:0071731) cellular response to nitric oxide(GO:0071732) cellular response to reactive nitrogen species(GO:1902170)
0.0	0.1	GO:0042693	muscle cell fate commitment(GO:0042693)
0.0	0.0	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.0	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.1	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.2	GO:0051156	glucose 6-phosphate metabolic process(GO:0051156)
0.0	0.0	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.2	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
0.0	0.1	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.0	0.1	GO:0009629	response to gravity(GO:0009629)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.1	GO:0043537	negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0	0.0	GO:0006663	platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0	0.0	GO:0006824	cobalt ion transport(GO:0006824)
0.0	0.1	GO:0044872	lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0	0.1	GO:0009435	NAD biosynthetic process(GO:0009435)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0071034	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.0	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.0	GO:0031297	replication fork processing(GO:0031297)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	0.2	GO:0033268	node of Ranvier(GO:0033268)
0.1	0.2	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.3	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.4	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0016342	catenin complex(GO:0016342)
0.0	0.2	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.2	GO:0071437	invadopodium(GO:0071437)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.2	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.2	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.3	GO:0030315	T-tubule(GO:0030315)
0.0	0.2	GO:0098644	complex of collagen trimers(GO:0098644)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.2	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.2	GO:0043256	laminin complex(GO:0043256)
0.0	0.1	GO:0060199	clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0	0.1	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0045277	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0	0.1	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0044291	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.1	GO:0051233	spindle midzone(GO:0051233)
0.0	0.0	GO:0001652	granular component(GO:0001652)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.1	GO:0034464	BBSome(GO:0034464)
0.0	0.2	GO:0016235	aggresome(GO:0016235)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.0	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.0	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	1.0	GO:0005925	focal adhesion(GO:0005925)
0.0	0.0	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.3	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.1	0.4	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.1	0.2	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	0.2	GO:0051425	PTB domain binding(GO:0051425)
0.1	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.4	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.3	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.3	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.3	GO:0005536	glucose binding(GO:0005536)
0.0	0.1	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.3	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0000987	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.0	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.4	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.4	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.3	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0030354	melanin-concentrating hormone activity(GO:0030354)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.2	GO:0022821	potassium ion antiporter activity(GO:0022821)
0.0	0.1	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.3	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.2	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.5	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.5	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.3	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.2	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.2	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.3	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.2	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.0	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.0	GO:0050543	icosatetraenoic acid binding(GO:0050543)
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.0	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.0	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.2	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.2	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.2	GO:0033613	activating transcription factor binding(GO:0033613)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.5	GO:0005518	collagen binding(GO:0005518)
0.0	0.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.0	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.0	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.0	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0051378	serotonin binding(GO:0051378)
0.0	0.0	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.0	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.2	GO:0030552	cAMP binding(GO:0030552)
0.0	0.0	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	0.0	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.2	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.0	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.0	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.0	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.2	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.0	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.0	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.0	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.0	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.0	0.1	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.0	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.0	GO:0004946	bombesin receptor activity(GO:0004946)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.1	PID IGF1 PATHWAY	IGF1 pathway
1.3	NABA COLLAGENS	Genes encoding collagen proteins
0.0	PID S1P S1P3 PATHWAY	S1P3 pathway
0.0	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.5	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.3	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.2	ST G ALPHA S PATHWAY	G alpha s Pathway
2.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	PID ARF 3PATHWAY	Arf1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.0	0.3	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.0	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.3	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.6	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	1.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.0	0.2	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.0	0.3	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.2	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.1	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.3	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.1	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	0.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.0	REACTOME P75NTR SIGNALS VIA NFKB	Genes involved in p75NTR signals via NF-kB
0.0	0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.3	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters