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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for HOXB3

Z-value: 1.50

Motif logo

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Transcription factors associated with HOXB3

Gene Symbol Gene ID Gene Info
HOXB3
ENSG00000120093.7 homeobox B3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr17_46654451_46654696HOXB321350.116487-0.844.5e-03Click!
chr17_46632798_46632949HOXB310100.266210-0.844.9e-03Click!
chr17_46655643_46655794HOXB310010.238854-0.835.8e-03Click!
chr17_46662373_46662833HOXB326190.098821-0.827.1e-03Click!
chr17_46654100_46654251HOXB317370.143918-0.809.0e-03Click!

Activity of the HOXB3 motif across conditions

Conditions sorted by the z-value of the HOXB3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr13_51051372_51051556 0.51 ENSG00000221198
 .
 114091
 0.07
chr17_66379311_66379462 0.47 ENSG00000207561
 .
 41303
 0.14
chr15_39652479_39652630 0.47 RP11-624L4.1
60356
 0.14
chr10_89436229_89436444 0.45 PAPSS2
 3'-phosphoadenosine 5'-phosphosulfate synthase 2
 15628
 0.19
chr7_150784838_150785537 0.42 AGAP3
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
 1033
 0.32
chr9_3360340_3360491 0.40 RFX3
 regulatory factor X, 3 (influences HLA class II expression)
 13651
 0.3
chr15_50194108_50194259 0.40 ATP8B4
 ATPase, class I, type 8B, member 4
 6107
 0.24
chr10_30347671_30348341 0.38 KIAA1462
 KIAA1462
 447
 0.9
chr7_133267178_133267329 0.37 EXOC4
 exocyst complex component 4
 6037
 0.35
chr4_89647157_89647308 0.37 FAM13A-AS1
 FAM13A antisense RNA 1
 4366
 0.21
chrX_39832066_39832217 0.37 BCOR
 BCL6 corepressor
 90049
 0.09
chr8_29057628_29057779 0.36 ENSG00000264328
 .
 57493
 0.09
chr12_62931646_62931797 0.36 ENSG00000202034
 .
 7738
 0.19
chr12_12016346_12017014 0.35 ETV6
 ets variant 6
 22191
 0.26
chr1_64549059_64549210 0.34 ENSG00000200508
 .
 16721
 0.18
chr6_97629282_97629433 0.33 MMS22L
 MMS22-like, DNA repair protein
 81871
 0.11
chr9_88955484_88955635 0.33 ZCCHC6
 zinc finger, CCHC domain containing 6
 2479
 0.34
chr12_81338456_81338607 0.32 LIN7A
 lin-7 homolog A (C. elegans)
 6827
 0.19
chr2_33662966_33663243 0.32 RASGRP3
 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
 1713
 0.48
chr20_43124845_43125142 0.32 SERINC3
 serine incorporator 3
 8539
 0.13
chrX_37702580_37702731 0.32 DYNLT3
 dynein, light chain, Tctex-type 3
 4006
 0.26
chr1_97899901_97900052 0.32 DPYD-IT1
 DPYD intronic transcript 1 (non-protein coding)
 14279
 0.31
chr11_71524282_71524863 0.32 ZNF705E
 zinc finger protein 705E
 6261
 0.1
chr17_66380501_66380857 0.31 ENSG00000207561
 .
 40010
 0.14
chr2_28344167_28344318 0.31 ENSG00000265321
 .
 125008
 0.05
chr6_134871939_134872090 0.31 SGK1
 serum/glucocorticoid regulated kinase 1
 232764
 0.02
chr16_87840292_87840843 0.31 RP4-536B24.2
29571
 0.14
chr6_39787204_39787470 0.30 DAAM2
 dishevelled associated activator of morphogenesis 2
 26543
 0.21
chr8_80226395_80226546 0.30 ENSG00000264969
 .
 216872
 0.02
chr2_118804547_118804712 0.30 ENSG00000243510
 .
 30671
 0.13
chr2_223875941_223876092 0.30 KCNE4
 potassium voltage-gated channel, Isk-related family, member 4
 40516
 0.17
chr11_6376113_6376264 0.30 PRKCDBP
 protein kinase C, delta binding protein
 34311
 0.11
chr8_101294374_101294525 0.29 RNF19A
 ring finger protein 19A, RBR E3 ubiquitin protein ligase
 21009
 0.2
chr1_36908138_36908289 0.29 OSCP1
 organic solute carrier partner 1
 1637
 0.28
chr5_5374817_5374968 0.29 KIAA0947
 KIAA0947
 47915
 0.19
chr7_39480916_39481067 0.29 POU6F2-AS1
 POU6F2 antisense RNA 1
 35046
 0.19
chr2_153267355_153267720 0.29 FMNL2
 formin-like 2
 75786
 0.12
chr2_145225492_145225643 0.29 ZEB2
 zinc finger E-box binding homeobox 2
 37430
 0.19
chr2_33501178_33501329 0.29 LTBP1
 latent transforming growth factor beta binding protein 1
 277
 0.93
chr2_189847314_189847465 0.28 ENSG00000221502
 .
 4571
 0.25
chr16_17931428_17931579 0.28 XYLT1
 xylosyltransferase I
 366765
 0.01
chr1_92207941_92208092 0.28 ENSG00000239794
 .
 87615
 0.09
chr7_15498785_15499062 0.28 AGMO
 alkylglycerol monooxygenase
 93076
 0.1
chr1_44412862_44413792 0.28 IPO13
 importin 13
 716
 0.44
chr15_79204771_79204922 0.28 ENSG00000252061
 .
 13568
 0.17
chr10_94452668_94452819 0.28 HHEX
 hematopoietically expressed homeobox
 1131
 0.51
chr6_107645107_107645353 0.27 PDSS2
 prenyl (decaprenyl) diphosphate synthase, subunit 2
 111867
 0.06
chr15_71824033_71824261 0.27 THSD4
 thrombospondin, type I, domain containing 4
 15428
 0.25
chr4_25407599_25407888 0.27 ANAPC4
 anaphase promoting complex subunit 4
 28801
 0.19
chr15_93579557_93579854 0.27 CHD2
 chromodomain helicase DNA binding protein 2
 27609
 0.2
chr3_156975213_156975364 0.27 ENSG00000243176
 .
 27220
 0.2
chr3_197784203_197784354 0.27 ENSG00000212297
 .
 14010
 0.14
chr3_14418133_14418284 0.27 ENSG00000199609
 .
 17940
 0.21
chr5_36300489_36300640 0.27 RANBP3L
 RAN binding protein 3-like
 1438
 0.48
chr9_3768105_3768256 0.27 RP11-252M18.3
107404
 0.07
chr5_57006064_57006215 0.27 ENSG00000221195
 .
 67326
 0.13
chr1_185390714_185391145 0.26 ENSG00000252407
 .
 12447
 0.26
chr9_128640336_128640592 0.26 PBX3
 pre-B-cell leukemia homeobox 3
 12914
 0.3
chr2_119427478_119427629 0.26 EN1
 engrailed homeobox 1
 177701
 0.03
chr7_116218439_116218590 0.26 AC006159.4
7226
 0.19
chr2_190018216_190018510 0.26 ENSG00000264725
 .
 20526
 0.19
chr18_56240273_56240424 0.26 RP11-126O1.2
16046
 0.15
chr13_115076948_115077099 0.26 CHAMP1
 chromosome alignment maintaining phosphoprotein 1
 2965
 0.23
chr5_38924606_38924757 0.26 OSMR
 oncostatin M receptor
 20181
 0.26
chr8_69903972_69904123 0.26 ENSG00000238808
 .
 118762
 0.07
chr8_19516504_19516655 0.26 CSGALNACT1
 chondroitin sulfate N-acetylgalactosaminyltransferase 1
 23515
 0.27
chr1_90290727_90290878 0.25 LRRC8D
 leucine rich repeat containing 8 family, member D
 3322
 0.28
chr3_29228707_29228858 0.25 RBMS3
 RNA binding motif, single stranded interacting protein 3
 93691
 0.09
chr14_82456075_82456226 0.25 SEL1L
 sel-1 suppressor of lin-12-like (C. elegans)
 455945
 0.01
chr22_46426709_46426860 0.25 RP6-109B7.5
22189
 0.1
chr4_119732850_119733001 0.25 SEC24D
 SEC24 family member D
 24368
 0.24
chr9_80524258_80524409 0.25 GNAQ
 guanine nucleotide binding protein (G protein), q polypeptide
 86418
 0.1
chr12_110388287_110388838 0.25 GIT2
 G protein-coupled receptor kinase interacting ArfGAP 2
 45467
 0.11
chr10_74248398_74248549 0.25 RP11-167P22.3
13031
 0.19
chr12_7596689_7596840 0.25 CD163L1
 CD163 molecule-like 1
 15
 0.98
chr4_40375661_40375812 0.25 ENSG00000239010
 .
 3794
 0.24
chr14_101308246_101309004 0.25 ENSG00000214548
 .
 7020
 0.04
chr17_66379496_66379718 0.25 ENSG00000207561
 .
 41082
 0.14
chr5_36928360_36928511 0.24 NIPBL
 Nipped-B homolog (Drosophila)
 51543
 0.18
chr1_52043843_52044143 0.24 OSBPL9
 oxysterol binding protein-like 9
 1142
 0.5
chr14_100240950_100241315 0.24 EML1
 echinoderm microtubule associated protein like 1
 1091
 0.59
chr5_169308984_169309135 0.24 FAM196B
 family with sequence similarity 196, member B
 98685
 0.07
chr12_1727335_1727720 0.24 WNT5B
 wingless-type MMTV integration site family, member 5B
 1305
 0.46
chr5_138288736_138289663 0.24 CTNNA1
 catenin (cadherin-associated protein), alpha 1, 102kDa
 22872
 0.17
chr10_75798433_75798584 0.24 RP11-417O11.5
33613
 0.15
chr11_19619185_19619336 0.24 ENSG00000207407
 .
 6422
 0.22
chr3_173610727_173610878 0.24 NLGN1-AS1
 NLGN1 antisense RNA 1
 27646
 0.27
chr5_90592330_90592999 0.24 ENSG00000199643
 .
 26120
 0.23
chr9_113926997_113927193 0.24 ENSG00000212409
 .
 67402
 0.12
chr1_56098686_56098837 0.24 ENSG00000272051
 .
 148116
 0.04
chr2_118817741_118818188 0.24 INSIG2
 insulin induced gene 2
 28086
 0.15
chr11_63278500_63278680 0.24 LGALS12
 lectin, galactoside-binding, soluble, 12
 3131
 0.21
chr12_105617824_105617982 0.24 APPL2
 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
 5735
 0.25
chr11_34338329_34338672 0.24 ABTB2
 ankyrin repeat and BTB (POZ) domain containing 2
 40302
 0.19
chr14_74724538_74725207 0.24 VSX2
 visual system homeobox 2
 18697
 0.14
chr7_101457741_101458764 0.24 CUX1
 cut-like homeobox 1
 707
 0.73
chr2_8012045_8012196 0.24 ENSG00000221255
 .
 295148
 0.01
chr15_70023529_70023680 0.24 ENSG00000238870
 .
 443
 0.88
chr2_158326449_158327167 0.24 CYTIP
 cytohesin 1 interacting protein
 18533
 0.22
chr8_13078515_13078765 0.23 DLC1
 deleted in liver cancer 1
 55415
 0.14
chr12_43709526_43709677 0.23 ENSG00000215993
 .
 24218
 0.27
chr11_109453346_109453497 0.23 RP11-708B6.2
948
 0.73
chr15_57527692_57527843 0.23 TCF12
 transcription factor 12
 12447
 0.25
chr1_109740426_109740857 0.23 ENSG00000238310
 .
 9829
 0.15
chr5_52192649_52192800 0.23 ITGA2
 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
 92432
 0.07
chr11_12436390_12436541 0.23 PARVA
 parvin, alpha
 16677
 0.24
chr11_121979710_121979861 0.23 RP11-166D19.1
3135
 0.2
chr11_103924198_103924349 0.23 PDGFD
 platelet derived growth factor D
 16519
 0.22
chr2_238221351_238221502 0.23 AC112715.2
 Uncharacterized protein
 55692
 0.13
chr4_86718935_86719260 0.23 ARHGAP24
 Rho GTPase activating protein 24
 19238
 0.25
chr4_26346811_26346962 0.23 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 2124
 0.47
chr4_169768965_169769116 0.23 RP11-635L1.3
14952
 0.19
chr15_65851048_65851199 0.23 ENSG00000207449
 .
 5598
 0.14
chr4_77680501_77680652 0.23 RP11-359D14.2
949
 0.62
chr17_3705503_3705718 0.23 ITGAE
 integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
 1073
 0.45
chr9_90131509_90131738 0.23 DAPK1
 death-associated protein kinase 1
 17703
 0.23
chr2_36720605_36720756 0.23 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 20153
 0.19
chr2_147081299_147081450 0.23 ENSG00000251905
 .
 178650
 0.04
chr12_52585492_52585885 0.23 KRT80
 keratin 80
 96
 0.95
chr7_37011204_37011355 0.23 ELMO1
 engulfment and cell motility 1
 13386
 0.2
chr9_112955106_112955494 0.23 C9orf152
 chromosome 9 open reading frame 152
 15169
 0.23
chr1_161691025_161691176 0.23 FCRLB
 Fc receptor-like B
 253
 0.86
chr13_24862558_24862709 0.23 SPATA13
 spermatogenesis associated 13
 15806
 0.14
chr2_62987338_62987489 0.23 ENSG00000252436
 .
 33538
 0.18
chr11_71778137_71778288 0.23 NUMA1
 nuclear mitotic apparatus protein 1
 2921
 0.12
chr2_145785636_145785787 0.23 ENSG00000253036
 .
 306927
 0.01
chr7_28104329_28104480 0.23 JAZF1
 JAZF zinc finger 1
 6899
 0.27
chr2_841280_841431 0.23 AC113607.3
75455
 0.1
chr1_184026988_184027139 0.23 TSEN15
 TSEN15 tRNA splicing endonuclease subunit
 6183
 0.25
chr2_145135123_145135336 0.23 GTDC1
 glycosyltransferase-like domain containing 1
 45146
 0.17
chr12_10194519_10194670 0.23 CLEC9A
 C-type lectin domain family 9, member A
 11318
 0.12
chr13_114871936_114872087 0.23 RASA3-IT1
 RASA3 intronic transcript 1 (non-protein coding)
 2284
 0.35
chr15_50148578_50148980 0.22 ATP8B4
 ATPase, class I, type 8B, member 4
 20113
 0.21
chrX_121759874_121760025 0.22 ENSG00000221317
 .
 154278
 0.04
chr2_52146184_52146335 0.22 ENSG00000202195
 .
 378874
 0.01
chr13_21289490_21289641 0.22 ENSG00000265710
 .
 11723
 0.19
chr4_122569979_122570130 0.22 ANXA5
 annexin A5
 48063
 0.16
chr13_77971472_77971623 0.22 MYCBP2
 MYC binding protein 2, E3 ubiquitin protein ligase
 70368
 0.12
chr6_11590032_11590183 0.22 TMEM170B
 transmembrane protein 170B
 51596
 0.15
chr11_101316311_101316462 0.22 ENSG00000263885
 .
 74250
 0.12
chr12_89453867_89454269 0.22 ENSG00000238302
 .
 221994
 0.02
chr21_40856650_40856801 0.22 SH3BGR
 SH3 domain binding glutamic acid-rich protein
 15024
 0.18
chr8_57425756_57425907 0.22 RP11-17A4.2
24174
 0.24
chr15_29022183_29022334 0.22 RP11-578F21.10
11490
 0.15
chr3_151082583_151082734 0.22 P2RY12
 purinergic receptor P2Y, G-protein coupled, 12
 19942
 0.17
chr20_48295346_48295512 0.22 B4GALT5
 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
 34986
 0.15
chr3_159740833_159741097 0.22 LINC01100
 long intergenic non-protein coding RNA 1100
 7154
 0.2
chr2_238442752_238442903 0.22 MLPH
 melanophilin
 6681
 0.17
chr4_148710085_148710236 0.22 ENSG00000264274
 .
 6414
 0.2
chr8_134591977_134592128 0.22 ST3GAL1
 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
 7869
 0.3
chr5_31990290_31990441 0.22 ENSG00000266243
 .
 54100
 0.13
chr2_36731284_36731435 0.22 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 9474
 0.2
chr9_138952025_138952443 0.22 NACC2
 NACC family member 2, BEN and BTB (POZ) domain containing
 9808
 0.22
chr2_200180531_200180682 0.22 RP11-486F17.1
9427
 0.3
chr5_90603533_90603789 0.22 ENSG00000199643
 .
 37117
 0.18
chr3_148722415_148722820 0.22 GYG1
 glycogenin 1
 12459
 0.19
chr11_92117975_92118126 0.22 RP11-675M1.2
23292
 0.23
chr8_16535817_16535968 0.22 MSR1
 macrophage scavenger receptor 1
 111021
 0.07
chr16_68100077_68100483 0.22 ENSG00000221789
 .
 10493
 0.1
chr14_32977387_32977538 0.22 AKAP6
 A kinase (PRKA) anchor protein 6
 13184
 0.26
chr15_56269998_56270149 0.22 NEDD4
 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
 15871
 0.2
chr1_10303434_10303585 0.22 KIF1B
 kinesin family member 1B
 11201
 0.16
chr10_4426416_4426567 0.22 ENSG00000207124
 .
 130653
 0.06
chr10_31272970_31273270 0.22 ZNF438
 zinc finger protein 438
 235
 0.96
chr4_54870791_54871088 0.22 AC110792.1
 HCG2027126; Uncharacterized protein
 56274
 0.12
chr15_63739639_63739912 0.22 USP3
 ubiquitin specific peptidase 3
 57018
 0.12
chr4_81228983_81229134 0.22 C4orf22
 chromosome 4 open reading frame 22
 27816
 0.2
chr2_158113855_158114082 0.22 GALNT5
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
 142
 0.97
chr11_122129149_122129397 0.22 RP11-716H6.2
36625
 0.18
chr3_153331537_153331688 0.22 ENSG00000200162
 .
 6446
 0.31
chr2_198094184_198094335 0.22 ANKRD44
 ankyrin repeat domain 44
 31497
 0.16
chr4_138463404_138463555 0.22 PCDH18
 protocadherin 18
 9831
 0.33
chr2_64515406_64515557 0.21 ENSG00000264297
 .
 52412
 0.14
chr6_125541820_125541971 0.21 TPD52L1
 tumor protein D52-like 1
 904
 0.71
chr3_81913343_81913495 0.21 GBE1
 glucan (1,4-alpha-), branching enzyme 1
 102107
 0.09
chr10_17151320_17151471 0.21 CUBN
 cubilin (intrinsic factor-cobalamin receptor)
 18441
 0.23
chr5_71501439_71501590 0.21 MAP1B
 microtubule-associated protein 1B
 26059
 0.19
chr16_70057514_70057665 0.21 ENSG00000239118
 .
 6660
 0.16
chr7_55491154_55491305 0.21 LANCL2
 LanC lantibiotic synthetase component C-like 2 (bacterial)
 58088
 0.14
chr3_108988791_108989046 0.21 ENSG00000252889
 .
 44942
 0.15
chr6_52430093_52430244 0.21 TRAM2
 translocation associated membrane protein 2
 11545
 0.25
chr1_78841651_78841802 0.21 ENSG00000212308
 .
 773
 0.75
chr3_145791643_145791794 0.21 RP11-274H2.3
4746
 0.16
chr13_73379676_73380042 0.21 DIS3
 DIS3 mitotic control homolog (S. cerevisiae)
 23625
 0.15
chr6_64389523_64389709 0.21 PHF3
 PHD finger protein 3
 30
 0.99
chr4_178223159_178223383 0.21 NEIL3
 nei endonuclease VIII-like 3 (E. coli)
 7719
 0.23
chr6_13437908_13438059 0.21 GFOD1
 glucose-fructose oxidoreductase domain containing 1
 29614
 0.15
chr3_112329096_112329326 0.21 CCDC80
 coiled-coil domain containing 80
 84
 0.98
chr15_38437640_38437791 0.21 SPRED1
 sprouty-related, EVH1 domain containing 1
 106812
 0.08
chr2_169772940_169773098 0.21 SPC25
 SPC25, NDC80 kinetochore complex component
 3232
 0.28
chr18_21470429_21470580 0.21 ENSG00000221389
 .
 3666
 0.25
chr17_68163620_68163771 0.21 KCNJ2
 potassium inwardly-rectifying channel, subfamily J, member 2
 1119
 0.45
chr3_183173438_183173589 0.21 ENSG00000251730
 .
 1597
 0.22
chr10_100288310_100288461 0.21 HPS1
 Hermansky-Pudlak syndrome 1
 81702
 0.09
chr2_9292545_9292696 0.21 ASAP2
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
 54274
 0.16
chr4_16771566_16771717 0.21 LDB2
 LIM domain binding 2
 95705
 0.09
chr21_35908494_35908645 0.21 RCAN1
 regulator of calcineurin 1
 9308
 0.2
chr5_35771841_35771992 0.21 SPEF2
 sperm flagellar 2
 7354
 0.25
chr7_81405925_81406300 0.21 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
 6358
 0.33
chr8_90731390_90731592 0.21 RIPK2
 receptor-interacting serine-threonine kinase 2
 38484
 0.22

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1900115 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.2 GO:0007132 meiotic metaphase I(GO:0007132)
0.1 0.2 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 0.2 GO:0071436 sodium ion export(GO:0071436)
0.1 0.1 GO:0021825 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.1 0.3 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.2 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.1 0.2 GO:0002328 pro-B cell differentiation(GO:0002328)
0.1 0.2 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 0.2 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1 0.3 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.2 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.1 0.3 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.1 0.3 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 0.2 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 0.1 GO:0070828 heterochromatin assembly(GO:0031507) heterochromatin organization(GO:0070828)
0.0 0.2 GO:0061001 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.2 GO:0021670 lateral ventricle development(GO:0021670)
0.0 0.2 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 1.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.3 GO:0006896 Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0 0.2 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:0003078 obsolete regulation of natriuresis(GO:0003078)
0.0 0.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0022030 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.0 0.2 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.1 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.0 0.0 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.8 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0046476 glycosylceramide biosynthetic process(GO:0046476)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0002870 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:2001279 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.1 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.0 GO:0002679 respiratory burst involved in defense response(GO:0002679)
0.0 0.1 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.1 GO:0090030 regulation of steroid hormone biosynthetic process(GO:0090030)
0.0 0.1 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.1 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.0 0.0 GO:0003283 atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:0060760 positive regulation of response to cytokine stimulus(GO:0060760)
0.0 0.1 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.1 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.1 GO:0001779 natural killer cell differentiation(GO:0001779)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.1 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0032431 activation of phospholipase A2 activity(GO:0032431)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:0009169 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.1 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.1 GO:0000492 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0016115 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 0.0 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.0 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0060754 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0032933 SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.3 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.1 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.0 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.0 GO:0002885 positive regulation of hypersensitivity(GO:0002885)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0042504 tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519) positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520)
0.0 0.0 GO:0044321 cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0 0.0 GO:0009125 nucleoside monophosphate catabolic process(GO:0009125)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.3 GO:0006195 purine nucleotide catabolic process(GO:0006195)
0.0 0.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.1 GO:0071347 cellular response to interleukin-1(GO:0071347)
0.0 0.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.1 GO:0021508 floor plate formation(GO:0021508)
0.0 0.0 GO:0002540 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.1 GO:0070528 protein kinase C signaling(GO:0070528)
0.0 0.0 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0 0.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.0 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
0.0 0.0 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.0 0.1 GO:0031033 myosin filament organization(GO:0031033)
0.0 0.1 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.2 GO:0010458 exit from mitosis(GO:0010458)
0.0 0.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.0 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.0 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.1 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 0.0 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.0 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.1 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.0 GO:0051459 corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0 0.0 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.0 GO:0032817 regulation of natural killer cell proliferation(GO:0032817)
0.0 0.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.0 GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus(GO:0002866)
0.0 0.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.0 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.0 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.0 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0032776 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.0 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.0 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.1 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.0 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.0 GO:0009261 ribonucleotide catabolic process(GO:0009261)
0.0 0.0 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.0 GO:0060014 granulosa cell differentiation(GO:0060014)
0.0 0.0 GO:0045915 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0 0.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.0 GO:0030540 female genitalia development(GO:0030540)
0.0 0.0 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0 0.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.1 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.0 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.0 GO:0021591 ventricular system development(GO:0021591)
0.0 0.0 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.0 GO:2000189 regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.0 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.0 GO:0034371 chylomicron remodeling(GO:0034371)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.0 GO:0071731 response to nitric oxide(GO:0071731) cellular response to nitric oxide(GO:0071732) cellular response to reactive nitrogen species(GO:1902170)
0.0 0.1 GO:0042693 muscle cell fate commitment(GO:0042693)
0.0 0.0 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.0 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.0 0.1 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.2 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.0 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0090231 regulation of spindle checkpoint(GO:0090231)
0.0 0.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.0 0.1 GO:0009629 response to gravity(GO:0009629)
0.0 0.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.1 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0043537 negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0 0.0 GO:0006663 platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0 0.0 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.1 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.1 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.1 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.0 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.0 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.0 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.0 GO:0031297 replication fork processing(GO:0031297)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0030934 anchoring collagen complex(GO:0030934)
0.1 0.2 GO:0033268 node of Ranvier(GO:0033268)
0.1 0.2 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0071437 invadopodium(GO:0071437)
0.0 0.2 GO:0000145 exocyst(GO:0000145)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.3 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:0043256 laminin complex(GO:0043256)
0.0 0.1 GO:0060199 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0 0.1 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.1 GO:0044291 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.1 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.0 GO:0001652 granular component(GO:0001652)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.2 GO:0016235 aggresome(GO:0016235)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.0 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.0 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 1.0 GO:0005925 focal adhesion(GO:0005925)
0.0 0.0 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.3 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.1 0.4 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 0.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 0.2 GO:0051425 PTB domain binding(GO:0051425)
0.1 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.0 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.3 GO:0005536 glucose binding(GO:0005536)
0.0 0.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0000987 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.1 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.4 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0030354 melanin-concentrating hormone activity(GO:0030354)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.2 GO:0022821 potassium ion antiporter activity(GO:0022821)
0.0 0.1 GO:0005350 pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0004516 nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.1 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.1 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.0 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.2 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.0 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 0.0 GO:0050543 icosatetraenoic acid binding(GO:0050543)
0.0 0.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.1 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.0 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.0 GO:0004075 biotin carboxylase activity(GO:0004075)
0.0 0.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.2 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.5 GO:0005518 collagen binding(GO:0005518)
0.0 0.0 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.0 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.0 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0051378 serotonin binding(GO:0051378)
0.0 0.0 GO:0052834 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.0 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0008518 reduced folate carrier activity(GO:0008518)
0.0 0.0 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.0 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0030552 cAMP binding(GO:0030552)
0.0 0.0 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.0 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.0 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.0 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.0 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.0 GO:0019958 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.0 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.0 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.0 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.0 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.0 GO:0004946 bombesin receptor activity(GO:0004946)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.1 PID IGF1 PATHWAY IGF1 pathway
0.0 1.3 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.0 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 0.0 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 0.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.1 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.3 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.0 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.0 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.2 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 2.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.2 PID ARF 3PATHWAY Arf1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.0 0.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.0 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.2 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.1 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.1 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.1 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.0 REACTOME P75NTR SIGNALS VIA NFKB Genes involved in p75NTR signals via NF-kB
0.0 0.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters