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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HOXB5

Z-value: 1.38

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Transcription factors associated with HOXB5

Gene Symbol	Gene ID	Gene Info
HOXB5 Ensembl NCBI GeneCards UniProt	ENSG00000120075.5	HOXB5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HOXB5	chr17_46670430_46670597	810	0.263584	0.35	3.5e-01	Click!
HOXB5	chr17_46670674_46671049	462	0.525865	-0.21	5.9e-01	Click!
HOXB5	chr17_46671392_46671683	214	0.805106	0.12	7.6e-01	Click!

Activity of the HOXB5 motif across conditions

Conditions sorted by the z-value of the HOXB5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_13457216_13457610	0.77	NUP210	nucleoporin 210kDa	4396	0.28
chr16_50720309_50720716	0.57	SNX20	sorting nexin 20	5248	0.13
chr2_143883953_143884119	0.55	ARHGAP15	Rho GTPase activating protein 15	2847	0.35
chr11_85903802_85903953	0.55	ENSG00000200877	.	39608	0.15
chr2_149304182_149304365	0.52	MBD5	methyl-CpG binding domain protein 5	77979	0.11
chr1_160544322_160544473	0.49	CD84	CD84 molecule	4866	0.16
chr14_22957256_22957407	0.48	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	1160	0.31
chr16_53544923_53545074	0.46	AKTIP	AKT interacting protein	6675	0.23
chr6_108278816_108278967	0.46	RP1-191J18.66		274	0.56
chr5_150623515_150623785	0.46	GM2A	GM2 ganglioside activator	8803	0.19
chr18_56324663_56325184	0.46	MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	13695	0.14
chr2_103034112_103034476	0.46	IL18RAP	interleukin 18 receptor accessory protein	855	0.53
chr5_175456482_175456633	0.45	THOC3	THO complex 3	5126	0.16
chr9_20997618_20997943	0.44	PTPLAD2	protein tyrosine phosphatase-like A domain containing 2	33828	0.16
chr14_52374460_52374611	0.44	GNG2	guanine nucleotide binding protein (G protein), gamma 2	5295	0.19
chr22_37620188_37620478	0.43	SSTR3	somatostatin receptor 3	11971	0.13
chr7_151046492_151046873	0.43	NUB1	negative regulator of ubiquitin-like proteins 1	4251	0.18
chr7_130784590_130784741	0.43	LINC-PINT	long intergenic non-protein coding RNA, p53 induced transcript	7124	0.22
chr1_32127594_32127745	0.42	COL16A1	collagen, type XVI, alpha 1	4013	0.15
chr17_7238561_7238964	0.42	ACAP1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	1086	0.22
chr17_33612463_33612749	0.42	SLFN5	schlafen family member 5	42498	0.11
chr17_66346042_66346193	0.41	ARSG	arylsulfatase G	58458	0.1
chr10_127515808_127515959	0.41	BCCIP	BRCA2 and CDKN1A interacting protein	3768	0.14
chr17_4404014_4404514	0.40	AC118754.4		1295	0.31
chr7_8056755_8056906	0.40	AC006042.7		47296	0.13
chr6_167534795_167535192	0.40	CCR6	chemokine (C-C motif) receptor 6	1264	0.46
chr16_28212646_28212858	0.40	XPO6	exportin 6	10045	0.17
chr20_48843581_48843732	0.39	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	36280	0.16
chr7_12770799_12771102	0.38	ENSG00000199470	.	30436	0.2
chr9_132629831_132629982	0.38	USP20	ubiquitin specific peptidase 20	32149	0.12
chr13_33296824_33296975	0.38	PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	35408	0.19
chr6_110500985_110501198	0.38	WASF1	WAS protein family, member 1	35	0.77
chr6_106095597_106095936	0.38	PREP	prolyl endopeptidase	244807	0.02
chr12_83108332_83108483	0.37	TMTC2	transmembrane and tetratricopeptide repeat containing 2	27627	0.27
chr5_95161582_95161941	0.37	GLRX	glutaredoxin (thioltransferase)	3052	0.2
chrX_118781177_118781328	0.37	ENSG00000211578	.	441	0.81
chr22_23486285_23486436	0.37	RTDR1	rhabdoid tumor deletion region gene 1	848	0.39
chr2_43355583_43355909	0.37	ENSG00000207087	.	37114	0.2
chr7_102069746_102070456	0.37	ORAI2	ORAI calcium release-activated calcium modulator 2	3452	0.11
chr5_75709889_75710222	0.37	IQGAP2	IQ motif containing GTPase activating protein 2	9806	0.28
chr1_157963439_157963975	0.37	KIRREL	kin of IRRE like (Drosophila)	272	0.93
chr2_153031608_153031759	0.36	STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	823	0.72
chr14_24021277_24021443	0.36	ZFHX2	zinc finger homeobox 2	502	0.64
chr18_56382154_56382522	0.36	RP11-126O1.4		37492	0.12
chr2_99068894_99069462	0.36	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	7765	0.25
chr15_81587451_81588017	0.35	IL16	interleukin 16	1520	0.42
chr13_100012790_100013013	0.35	ENSG00000207719	.	4516	0.25
chr12_6892610_6892761	0.35	ENSG00000244532	.	642	0.46
chrX_64945443_64945693	0.35	MSN	moesin	58031	0.16
chr6_143861183_143861457	0.35	PHACTR2	phosphatase and actin regulator 2	3338	0.21
chr8_129694153_129694304	0.35	ENSG00000221351	.	137812	0.05
chrX_101857495_101857646	0.35	ARMCX5	armadillo repeat containing, X-linked 5	1505	0.37
chrX_70324332_70324541	0.35	CXorf65	chromosome X open reading frame 65	2019	0.18
chr17_72752966_72753168	0.35	SLC9A3R1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	5075	0.11
chr15_91081084_91081235	0.34	CRTC3	CREB regulated transcription coactivator 3	7859	0.21
chr1_160537117_160537336	0.34	CD84	CD84 molecule	12037	0.14
chr1_202597717_202597987	0.34	SYT2	synaptotagmin II	14729	0.19
chr14_93105749_93105900	0.34	RIN3	Ras and Rab interactor 3	13022	0.27
chr11_44630544_44630700	0.34	RP11-58K22.4		971	0.55
chr3_47025143_47025429	0.34	CCDC12	coiled-coil domain containing 12	1814	0.32
chr13_52393868_52394096	0.34	RP11-327P2.5		15549	0.18
chr6_52262511_52262820	0.34	EFHC1	EF-hand domain (C-terminal) containing 1	22441	0.2
chr6_53199538_53199739	0.34	ELOVL5	ELOVL fatty acid elongase 5	13949	0.2
chr5_39189552_39189909	0.34	FYB	FYN binding protein	13399	0.27
chr6_45563562_45563713	0.33	ENSG00000252738	.	50204	0.18
chr5_1314270_1314421	0.33	ENSG00000263670	.	4853	0.19
chr1_158255508_158255815	0.33	CD1C	CD1c molecule	3915	0.22
chr1_226863115_226863281	0.33	ITPKB-IT1	ITPKB intronic transcript 1 (non-protein coding)	430	0.85
chr5_176172799_176173168	0.33	UNC5A	unc-5 homolog A (C. elegans)	64495	0.09
chr16_88759405_88759694	0.33	RP5-1142A6.5		3360	0.09
chr19_41813754_41814061	0.33	CCDC97	coiled-coil domain containing 97	2187	0.19
chr2_71562064_71562215	0.33	ZNF638	zinc finger protein 638	3227	0.29
chr14_61977064_61977273	0.33	RP11-47I22.4		18678	0.19
chrX_135702154_135702305	0.33	ENSG00000233093	.	19473	0.14
chr4_109031937_109032201	0.32	LEF1	lymphoid enhancer-binding factor 1	55388	0.13
chr3_53063759_53063910	0.32	SFMBT1	Scm-like with four mbt domains 1	15447	0.17
chr1_36678399_36678593	0.32	THRAP3	thyroid hormone receptor associated protein 3	11521	0.15
chr15_63783402_63783553	0.32	USP3	ubiquitin specific peptidase 3	13316	0.23
chr5_66483406_66483586	0.32	CD180	CD180 molecule	9131	0.28
chr10_115967390_115967541	0.32	TDRD1	tudor domain containing 1	28116	0.14
chr1_184944092_184944619	0.32	FAM129A	family with sequence similarity 129, member A	673	0.75
chr1_89486291_89486615	0.32	ENSG00000202385	.	405	0.78
chrX_123353114_123353327	0.31	ENSG00000252693	.	21627	0.25
chr17_15905285_15905436	0.31	ZSWIM7	zinc finger, SWIM-type containing 7	2354	0.22
chr13_99916204_99916355	0.31	GPR18	G protein-coupled receptor 18	2281	0.31
chr16_30379858_30380009	0.31	TBC1D10B	TBC1 domain family, member 10B	1652	0.17
chr6_112311050_112311201	0.31	WISP3	WNT1 inducible signaling pathway protein 3	64150	0.11
chr15_45024051_45024202	0.31	TRIM69	tripartite motif containing 69	2940	0.21
chr11_128382093_128382244	0.31	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	6879	0.25
chr12_58027267_58027418	0.31	B4GALNT1	beta-1,4-N-acetyl-galactosaminyl transferase 1	204	0.86
chr3_45430424_45430606	0.31	LARS2	leucyl-tRNA synthetase 2, mitochondrial	404	0.9
chr1_38316786_38316995	0.31	MTF1	metal-regulatory transcription factor 1	8402	0.1
chr6_155070964_155071137	0.31	SCAF8	SR-related CTD-associated factor 8	16500	0.23
chr1_158984706_158984928	0.31	IFI16	interferon, gamma-inducible protein 16	346	0.89
chr1_28453002_28453170	0.31	ENSG00000253005	.	16266	0.12
chr3_15597201_15597352	0.31	COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	34018	0.12
chr11_123552269_123552420	0.31	SCN3B	sodium channel, voltage-gated, type III, beta subunit	26392	0.14
chr17_8858889_8859261	0.31	PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	9949	0.24
chr6_43299390_43299611	0.30	ZNF318	zinc finger protein 318	11074	0.14
chr17_72984009_72984428	0.30	CDR2L	cerebellar degeneration-related protein 2-like	491	0.63
chr5_66809962_66810113	0.30	ENSG00000222939	.	49601	0.2
chr3_10280429_10280763	0.30	TATDN2	TatD DNase domain containing 2	9111	0.13
chr7_142378423_142378715	0.30	MTRNR2L6	MT-RNR2-like 6	4465	0.28
chr5_142737307_142737458	0.30	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	43035	0.2
chr21_34606770_34607111	0.30	IFNAR2	interferon (alpha, beta and omega) receptor 2	4226	0.17
chr6_118002568_118002719	0.30	NUS1	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)	5978	0.3
chr10_13148496_13148807	0.30	OPTN	optineurin	6426	0.2
chr17_62010060_62010211	0.30	CD79B	CD79b molecule, immunoglobulin-associated beta	421	0.74
chr8_146018396_146018558	0.30	RPL8	ribosomal protein L8	505	0.65
chr22_17570345_17570505	0.30	IL17RA	interleukin 17 receptor A	4576	0.19
chr11_117884308_117884597	0.29	IL10RA	interleukin 10 receptor, alpha	27343	0.14
chr6_34152409_34152560	0.29	GRM4	glutamate receptor, metabotropic 4	29085	0.17
chrX_118789581_118789748	0.29	ENSG00000211578	.	8853	0.17
chr3_130613754_130614033	0.29	ATP2C1	ATPase, Ca++ transporting, type 2C, member 1	408	0.84
chr8_2077178_2077450	0.29	MYOM2	myomesin 2	84130	0.11
chr13_99931416_99931591	0.29	GPR18	G protein-coupled receptor 18	17505	0.18
chr1_9477618_9477769	0.29	ENSG00000252956	.	20144	0.21
chr1_158218506_158218726	0.29	CD1A	CD1a molecule	5311	0.22
chr18_43268903_43269487	0.29	SLC14A2	solute carrier family 14 (urea transporter), member 2	23088	0.16
chr15_86249746_86250319	0.29	RP11-815J21.1		5692	0.13
chr9_140195094_140195255	0.29	NRARP	NOTCH-regulated ankyrin repeat protein	1529	0.21
chr1_1712444_1712922	0.29	NADK	NAD kinase	1175	0.4
chr13_74591900_74592051	0.28	KLF12	Kruppel-like factor 12	22789	0.29
chr3_186776851_186777002	0.28	ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	15395	0.23
chr5_169744528_169744722	0.28	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	19394	0.19
chr12_56733182_56733440	0.28	IL23A	interleukin 23, alpha subunit p19	648	0.46
chrX_100662156_100662307	0.28	GLA	galactosidase, alpha	682	0.45
chrX_65225891_65226383	0.28	RP6-159A1.3		6544	0.22
chr4_89199715_89199866	0.28	ENSG00000200469	.	3330	0.19
chr12_113621285_113621493	0.28	DDX54	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	218	0.86
chr4_103546216_103546367	0.28	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	47270	0.15
chr1_110331899_110332050	0.28	EPS8L3	EPS8-like 3	25325	0.13
chr15_30468678_30468972	0.27	ENSG00000221785	.	31745	0.11
chr20_48329492_48329643	0.27	B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	848	0.61
chr2_27071961_27072112	0.27	DPYSL5	dihydropyrimidinase-like 5	660	0.72
chr15_86325217_86325368	0.27	ENSG00000221634	.	11483	0.11
chr3_17621324_17621533	0.27	TBC1D5	TBC1 domain family, member 5	43980	0.2
chr9_15300217_15300592	0.27	TTC39B	tetratricopeptide repeat domain 39B	6803	0.25
chr1_36634160_36634311	0.27	MAP7D1	MAP7 domain containing 1	8083	0.14
chr20_3725478_3725931	0.27	HSPA12B	heat shock 70kD protein 12B	12346	0.12
chr20_62579033_62579428	0.27	UCKL1	uridine-cytidine kinase 1-like 1	3249	0.09
chrY_7188749_7188900	0.27	ENSG00000252633	.	3812	0.24
chr18_21514931_21515082	0.27	LAMA3	laminin, alpha 3	6803	0.22
chr11_113948126_113948329	0.27	ENSG00000221112	.	9424	0.21
chr1_156457116_156457326	0.27	MEF2D	myocyte enhancer factor 2D	3170	0.16
chr1_182599288_182599608	0.27	RGS16	regulator of G-protein signaling 16	25905	0.17
chrX_135747491_135747642	0.27	CD40LG	CD40 ligand	17180	0.17
chr9_316050_316201	0.26	DOCK8	dedicator of cytokinesis 8	43055	0.14
chr15_32654105_32654382	0.26	ENSG00000221444	.	31430	0.1
chr11_121521536_121521776	0.26	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	60528	0.16
chr18_74176432_74176583	0.26	ZNF516	zinc finger protein 516	26228	0.16
chr10_17548800_17549076	0.26	ST8SIA6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	52609	0.13
chr16_3122157_3122311	0.26	ENSG00000252561	.	2710	0.09
chr14_68951873_68952122	0.26	RAD51B	RAD51 paralog B	73770	0.11
chr2_198075933_198076206	0.26	ANKRD44	ankyrin repeat domain 44	13307	0.2
chr12_64978366_64978542	0.26	ENSG00000223294	.	9009	0.14
chr12_58175242_58176026	0.26	TSFM	Ts translation elongation factor, mitochondrial	738	0.36
chr3_31592528_31592679	0.26	STT3B	STT3B, subunit of the oligosaccharyltransferase complex (catalytic)	18321	0.28
chr8_129556248_129556417	0.26	ENSG00000221351	.	275708	0.01
chr1_154312907_154313058	0.26	ENSG00000238365	.	1763	0.21
chr15_70849476_70849729	0.26	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	145018	0.05
chr17_26876127_26876878	0.26	UNC119	unc-119 homolog (C. elegans)	85	0.93
chr1_248905757_248905908	0.26	LYPD8	LY6/PLAUR domain containing 8	2682	0.28
chr14_100568921_100569190	0.26	EVL	Enah/Vasp-like	5771	0.14
chr15_92401400_92401706	0.26	SLCO3A1	solute carrier organic anion transporter family, member 3A1	4202	0.3
chr2_198294526_198294745	0.26	SF3B1	splicing factor 3b, subunit 1, 155kDa	5116	0.15
chr3_15319690_15320104	0.26	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	2345	0.23
chr3_122295994_122296195	0.26	PARP15	poly (ADP-ribose) polymerase family, member 15	355	0.86
chr1_55070670_55070938	0.26	FAM151A	family with sequence similarity 151, member A	18425	0.14
chr2_69006771_69007110	0.25	ARHGAP25	Rho GTPase activating protein 25	4868	0.27
chr10_17703984_17704256	0.25	ENSG00000251959	.	17067	0.14
chr2_65172918_65173113	0.25	ENSG00000238696	.	37195	0.12
chr1_76751688_76751938	0.25	ST6GALNAC3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	211409	0.02
chr10_97415695_97415896	0.25	ALDH18A1	aldehyde dehydrogenase 18 family, member A1	668	0.74
chr11_118109252_118109403	0.25	AMICA1	adhesion molecule, interacts with CXADR antigen 1	13518	0.13
chr7_150267291_150267625	0.25	GIMAP4	GTPase, IMAP family member 4	2934	0.27
chr3_186657505_186657656	0.25	ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	8439	0.21
chr7_77317684_77317835	0.25	RSBN1L	round spermatid basic protein 1-like	8001	0.26
chr2_99312607_99313038	0.25	MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	30337	0.18
chr8_126661069_126661220	0.25	ENSG00000266452	.	204337	0.03
chr18_60881389_60881563	0.25	ENSG00000238988	.	19578	0.21
chr15_75642153_75642345	0.25	NEIL1	nei endonuclease VIII-like 1 (E. coli)	1509	0.26
chr11_121331911_121332238	0.25	RP11-730K11.1		8352	0.25
chr1_156183961_156184321	0.25	PMF1-BGLAP	PMF1-BGLAP readthrough	1341	0.22
chr1_111436803_111436998	0.24	CD53	CD53 molecule	21124	0.16
chr9_6422321_6422472	0.24	UHRF2	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase	1365	0.45
chr19_30172794_30172945	0.24	PLEKHF1	pleckstrin homology domain containing, family F (with FYVE domain) member 1	15088	0.21
chrX_19795655_19795879	0.24	SH3KBP1	SH3-domain kinase binding protein 1	22102	0.26
chr1_111180656_111180873	0.24	KCNA2	potassium voltage-gated channel, shaker-related subfamily, member 2	6668	0.19
chr3_42390480_42390631	0.24	LYZL4	lysozyme-like 4	61495	0.1
chr9_130532441_130532713	0.24	SH2D3C	SH2 domain containing 3C	1140	0.29
chr8_126661631_126661782	0.24	ENSG00000266452	.	204899	0.02
chr8_95229930_95230081	0.24	CDH17	cadherin 17, LI cadherin (liver-intestine)	474	0.86
chr6_53202509_53202860	0.24	ELOVL5	ELOVL fatty acid elongase 5	10903	0.21
chr3_133300803_133300954	0.24	CDV3	CDV3 homolog (mouse)	7386	0.21
chr6_125390047_125390198	0.24	RNF217	ring finger protein 217	20764	0.24
chr3_50657101_50657507	0.24	MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	2483	0.23
chr20_30973001_30973152	0.24	ASXL1	additional sex combs like 1 (Drosophila)	25526	0.17
chr2_198192116_198192267	0.24	AC010746.3		16074	0.15
chr14_67983023_67983217	0.23	TMEM229B	transmembrane protein 229B	932	0.54

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.1	0.1	GO:0071481	cellular response to X-ray(GO:0071481)
0.1	0.2	GO:0009301	snRNA transcription(GO:0009301)
0.1	0.3	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.1	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.3	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0016137	glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0006452	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.1	GO:0051140	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0	0.2	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.2	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.2	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.1	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.1	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0034122	negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0	0.1	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.1	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:2000041	regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.3	GO:0030224	monocyte differentiation(GO:0030224)
0.0	0.1	GO:0070254	mucus secretion(GO:0070254)
0.0	0.1	GO:1904035	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.0	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0	0.1	GO:0006210	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0046599	regulation of centriole replication(GO:0046599)
0.0	0.0	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.0	0.1	GO:0000042	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.0	GO:0002579	positive regulation of antigen processing and presentation(GO:0002579)
0.0	0.1	GO:0021780	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.0	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0	0.1	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:2001012	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.0	0.2	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.2	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.1	GO:0016093	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0052167	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0	0.0	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.1	GO:0031342	negative regulation of leukocyte mediated cytotoxicity(GO:0001911) negative regulation of cell killing(GO:0031342)
0.0	0.1	GO:0046502	uroporphyrinogen III metabolic process(GO:0046502)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.2	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.0	GO:0033091	positive regulation of immature T cell proliferation(GO:0033091)
0.0	0.0	GO:0021801	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0010310	regulation of hydrogen peroxide metabolic process(GO:0010310)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.1	GO:0032328	alanine transport(GO:0032328)
0.0	0.1	GO:0046880	regulation of follicle-stimulating hormone secretion(GO:0046880) negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.1	GO:0019883	antigen processing and presentation of endogenous antigen(GO:0019883)
0.0	0.1	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	0.1	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.1	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.1	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.1	GO:0032203	telomere formation via telomerase(GO:0032203)
0.0	0.1	GO:0032784	regulation of DNA-templated transcription, elongation(GO:0032784)
0.0	0.1	GO:0061099	negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.1	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0002678	positive regulation of chronic inflammatory response(GO:0002678)
0.0	0.0	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.0	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0032627	interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.0	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0	0.0	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0003341	cilium movement(GO:0003341)
0.0	0.1	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.0	GO:0050849	negative regulation of calcium-mediated signaling(GO:0050849)
0.0	0.1	GO:0009812	flavonoid metabolic process(GO:0009812)
0.0	0.2	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.1	GO:0035066	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:1901072	amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.0	GO:0002475	antigen processing and presentation via MHC class Ib(GO:0002475)
0.0	0.0	GO:0061303	cornea development in camera-type eye(GO:0061303)
0.0	0.0	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0045022	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.1	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.0	0.0	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.0	GO:0002125	maternal aggressive behavior(GO:0002125)
0.0	0.1	GO:0008628	hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0	0.0	GO:0042109	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.1	GO:0046666	retinal cell programmed cell death(GO:0046666)
0.0	0.0	GO:0015816	glycine transport(GO:0015816)
0.0	0.2	GO:0050672	negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) negative regulation of leukocyte proliferation(GO:0070664)
0.0	0.1	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.2	GO:0042572	retinol metabolic process(GO:0042572)
0.0	0.0	GO:0046958	nonassociative learning(GO:0046958)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.0	GO:0009414	response to water deprivation(GO:0009414) response to water(GO:0009415)
0.0	0.3	GO:0006612	protein targeting to membrane(GO:0006612)
0.0	0.3	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.0	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0032099	negative regulation of appetite(GO:0032099)
0.0	0.0	GO:0016102	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.0	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0032069	regulation of nuclease activity(GO:0032069)
0.0	0.1	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.0	GO:0002883	hypersensitivity(GO:0002524) regulation of hypersensitivity(GO:0002883) positive regulation of hypersensitivity(GO:0002885)
0.0	0.3	GO:0050772	positive regulation of axonogenesis(GO:0050772)
0.0	0.0	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.0	GO:0016241	regulation of macroautophagy(GO:0016241)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:0043584	nose development(GO:0043584)
0.0	0.0	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.0	GO:0045056	transcytosis(GO:0045056)
0.0	0.0	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.0	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.0	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.1	GO:0006359	regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0	0.4	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0001940	male pronucleus(GO:0001940)
0.1	0.2	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.4	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0000346	transcription export complex(GO:0000346)
0.0	0.0	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0042583	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.3	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.2	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.0	GO:0008537	proteasome activator complex(GO:0008537)
0.0	0.0	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.0	GO:0005638	lamin filament(GO:0005638)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1	0.1	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.1	0.3	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.2	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.2	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.3	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.2	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.5	GO:0030331	estrogen receptor binding(GO:0030331)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.2	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.2	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.2	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.4	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.2	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.2	GO:0017136	NAD-dependent histone deacetylase activity(GO:0017136)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0061630	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0003711	obsolete transcription elongation regulator activity(GO:0003711)
0.0	0.1	GO:0003964	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.2	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.3	GO:0008376	acetylgalactosaminyltransferase activity(GO:0008376)
0.0	0.1	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	0.0	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.2	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.0	0.3	GO:0019843	rRNA binding(GO:0019843)
0.0	0.0	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.1	GO:0017081	chloride channel regulator activity(GO:0017081)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.0	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.0	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0019894	kinesin binding(GO:0019894)
0.0	0.0	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.0	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.1	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0	0.1	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.0	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.8	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.7	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.5	PID BCR 5PATHWAY	BCR signaling pathway
0.5	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.4	PID IL2 1PATHWAY	IL2-mediated signaling events
0.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.5	PID RAC1 PATHWAY	RAC1 signaling pathway
0.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.2	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.3	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.3	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.2	PID CDC42 REG PATHWAY	Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.3	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.8	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.6	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.0	0.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.2	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.3	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.3	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.2	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.2	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.0	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	0.0	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.0	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.2	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.3	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases