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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HOXC10_HOXD13

Z-value: 0.71

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Transcription factors associated with HOXC10_HOXD13

Gene Symbol	Gene ID	Gene Info
HOXC10 Ensembl NCBI GeneCards UniProt	ENSG00000180818.4	HOXC10
HOXD13 Ensembl NCBI GeneCards UniProt	ENSG00000128714.5	HOXD13

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HOXC10	chr12_54378978_54379226	132	0.523416	-0.36	3.4e-01	Click!
HOXD13	chr2_176953314_176953465	4230	0.101143	0.73	2.7e-02	Click!
HOXD13	chr2_176958437_176958600	899	0.355888	0.53	1.4e-01	Click!
HOXD13	chr2_176957910_176958434	553	0.559704	-0.38	3.1e-01	Click!
HOXD13	chr2_176956847_176957065	663	0.484831	0.28	4.6e-01	Click!
HOXD13	chr2_176953141_176953292	4403	0.099735	0.25	5.1e-01	Click!

Activity of the HOXC10_HOXD13 motif across conditions

Conditions sorted by the z-value of the HOXC10_HOXD13 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_198060963_198061183	0.33	AC013264.2		1642	0.33
chr12_837359_837675	0.30	WNK1	WNK lysine deficient protein kinase 1	24242	0.18
chr15_60828599_60828948	0.26	CTD-2501E16.2		6601	0.21
chr3_71461863_71462033	0.25	FOXP1	forkhead box P1	108037	0.07
chr5_100224229_100224437	0.23	ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	14585	0.28
chr13_77882140_77882385	0.22	MYCBP2	MYC binding protein 2, E3 ubiquitin protein ligase	18552	0.28
chr1_184718801_184718952	0.22	EDEM3	ER degradation enhancer, mannosidase alpha-like 3	4825	0.26
chr6_112035271_112035422	0.21	FYN	FYN oncogene related to SRC, FGR, YES	5919	0.26
chr3_141270944_141271180	0.21	RASA2-IT1	RASA2 intronic transcript 1 (non-protein coding)	27087	0.21
chr9_98486374_98486879	0.21	DKFZP434H0512	Protein LOC100506667; Putative uncharacterized protein DKFZp434H0512	47979	0.17
chr17_46375004_46375203	0.21	AC090627.1		3366	0.23
chr1_100847278_100847500	0.20	ENSG00000216067	.	3058	0.27
chr1_86854784_86854976	0.20	ODF2L	outer dense fiber of sperm tails 2-like	6001	0.25
chr11_88576113_88576264	0.20	GRM5	glutamate receptor, metabotropic 5	204350	0.03
chr1_116931483_116931823	0.19	AL136376.1	Uncharacterized protein	4935	0.17
chr4_139937547_139937724	0.19	CCRN4L	CCR4 carbon catabolite repression 4-like (S. cerevisiae)	692	0.51
chr2_198100640_198101238	0.19	ANKRD44	ankyrin repeat domain 44	38177	0.14
chr3_53069303_53069506	0.19	SFMBT1	Scm-like with four mbt domains 1	9877	0.18
chr7_105348761_105348986	0.18	ATXN7L1	ataxin 7-like 1	16789	0.26
chr2_135014379_135014599	0.18	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	2659	0.35
chr14_73610281_73610452	0.18	PSEN1	presenilin 1	3834	0.24
chr13_31201174_31201431	0.18	USPL1	ubiquitin specific peptidase like 1	9382	0.23
chr4_110612664_110612815	0.17	AC004067.5		421	0.84
chr8_126950940_126951091	0.17	ENSG00000206695	.	37820	0.23
chr16_57021435_57021712	0.17	NLRC5	NLR family, CARD domain containing 5	1837	0.25
chr10_63998636_63998943	0.17	RTKN2	rhotekin 2	2767	0.38
chr14_99647139_99647315	0.17	AL162151.4		22474	0.23
chr3_18784592_18784781	0.17	ENSG00000228956	.	2550	0.44
chr2_101918683_101918948	0.17	RNF149	ring finger protein 149	6343	0.18
chr8_125490405_125490556	0.17	RNF139	ring finger protein 139	3501	0.2
chr2_48543908_48544266	0.16	FOXN2	forkhead box N2	2238	0.35
chr14_62265738_62265889	0.16	SNAPC1	small nuclear RNA activating complex, polypeptide 1, 43kDa	36738	0.21
chr16_17397269_17397420	0.16	XYLT1	xylosyltransferase I	167394	0.04
chr2_109582380_109582745	0.16	EDAR	ectodysplasin A receptor	23163	0.25
chrX_135710444_135710648	0.16	ENSG00000233093	.	11156	0.16
chr20_52490835_52490986	0.16	AC005220.3		65789	0.13
chr2_158269106_158269275	0.16	CYTIP	cytohesin 1 interacting protein	26736	0.19
chr16_53498380_53498624	0.16	RBL2	retinoblastoma-like 2 (p130)	14514	0.15
chr7_105515189_105515340	0.16	ATXN7L1	ataxin 7-like 1	1659	0.51
chr4_143621409_143621560	0.16	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	139662	0.05
chr15_60085307_60085458	0.16	BNIP2	BCL2/adenovirus E1B 19kDa interacting protein 2	103649	0.06
chr2_143888983_143889411	0.16	ARHGAP15	Rho GTPase activating protein 15	2314	0.39
chr4_47829221_47829372	0.16	CORIN	corin, serine peptidase	10670	0.21
chr4_74117360_74117511	0.16	ANKRD17	ankyrin repeat domain 17	6604	0.19
chr4_73953344_73953495	0.16	COX18	COX18 cytochrome C oxidase assembly factor	17961	0.23
chr6_35566907_35567293	0.16	ENSG00000212579	.	52495	0.1
chr6_52151518_52151818	0.16	MCM3	minichromosome maintenance complex component 3	2033	0.36
chr1_151133033_151133283	0.16	SCNM1	sodium channel modifier 1	4018	0.1
chr2_197014969_197015443	0.16	RP11-347P5.1		781	0.66
chr2_204812325_204812548	0.15	ICOS	inducible T-cell co-stimulator	10933	0.28
chr7_142500387_142500538	0.15	PRSS3P2	protease, serine, 3 pseudogene 2	19331	0.16
chr17_40750860_40751042	0.15	FAM134C	family with sequence similarity 134, member C	10431	0.08
chr4_78726314_78726465	0.15	CNOT6L	CCR4-NOT transcription complex, subunit 6-like	13828	0.26
chr10_134069250_134069918	0.15	STK32C	serine/threonine kinase 32C	51134	0.12
chr12_121323357_121323508	0.15	SPPL3	signal peptide peptidase like 3	17741	0.17
chr8_82011673_82011842	0.15	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	12546	0.28
chr11_96023136_96023287	0.15	ENSG00000266192	.	51391	0.14
chr12_47710625_47710974	0.15	ENSG00000199566	.	29281	0.17
chr1_66831872_66832123	0.15	PDE4B	phosphodiesterase 4B, cAMP-specific	11932	0.3
chr2_204596528_204596679	0.15	CD28	CD28 molecule	25187	0.19
chr3_151911039_151911356	0.15	MBNL1	muscleblind-like splicing regulator 1	74632	0.11
chr11_10819600_10819751	0.15	EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	2354	0.19
chr2_32036582_32036828	0.15	ENSG00000238448	.	1348	0.49
chr6_109357989_109358140	0.15	ENSG00000199944	.	22753	0.16
chr15_38904317_38904468	0.15	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	46616	0.14
chr2_192505177_192505550	0.15	NABP1	nucleic acid binding protein 1	37499	0.21
chr3_107697281_107697722	0.15	CD47	CD47 molecule	79707	0.11
chr8_48594509_48594782	0.15	ENSG00000207369	.	14312	0.19
chr4_100765453_100765604	0.15	DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	27525	0.18
chr5_59892964_59893115	0.15	DEPDC1B	DEP domain containing 1B	102922	0.07
chr1_160682851_160683057	0.15	CD48	CD48 molecule	1313	0.4
chr1_171470969_171471120	0.15	ENSG00000239373	.	9494	0.15
chr20_51025367_51025552	0.15	ZFP64	ZFP64 zinc finger protein	216934	0.02
chrX_123476453_123476604	0.15	SH2D1A	SH2 domain containing 1A	3666	0.37
chr8_29964950_29965250	0.15	LEPROTL1	leptin receptor overlapping transcript-like 1	5644	0.16
chr14_98606379_98606534	0.15	C14orf64	chromosome 14 open reading frame 64	161995	0.04
chr1_92942408_92942722	0.14	GFI1	growth factor independent 1 transcription repressor	6946	0.27
chr2_198150239_198150434	0.14	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	16907	0.16
chr14_38540644_38540853	0.14	CTD-2058B24.2		19615	0.24
chr15_60843099_60843250	0.14	CTD-2501E16.2		21002	0.18
chr9_97347238_97347389	0.14	FBP2	fructose-1,6-bisphosphatase 2	8762	0.24
chrX_56594702_56594894	0.14	UBQLN2	ubiquilin 2	4772	0.35
chr4_114614482_114614847	0.14	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	67560	0.14
chr3_56729846_56730094	0.14	FAM208A	family with sequence similarity 208, member A	12705	0.27
chr15_81586884_81587161	0.14	IL16	interleukin 16	2232	0.32
chr2_99278059_99278217	0.14	MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	1798	0.39
chr11_14721093_14721244	0.14	PDE3B	phosphodiesterase 3B, cGMP-inhibited	55791	0.14
chr6_16420917_16421068	0.14	ENSG00000265642	.	7762	0.31
chr19_2850075_2850226	0.14	AC006130.3		8564	0.1
chr1_226067346_226067612	0.14	TMEM63A	transmembrane protein 63A	2100	0.22
chr1_198578902_198579207	0.14	PTPRC	protein tyrosine phosphatase, receptor type, C	28747	0.21
chr3_71127524_71127675	0.14	FOXP1	forkhead box P1	12681	0.31
chr9_2053303_2053454	0.14	RP11-264I13.2		7355	0.25
chr6_135333699_135333925	0.14	HBS1L	HBS1-like (S. cerevisiae)	14482	0.21
chr6_108958559_108958710	0.14	FOXO3	forkhead box O3	18915	0.27
chr8_20131803_20131954	0.14	ENSG00000253733	.	15807	0.18
chr12_55129725_55129876	0.14	DCD	dermcidin	87523	0.07
chr6_149793703_149793934	0.14	ZC3H12D	zinc finger CCCH-type containing 12D	10451	0.17
chr10_14618640_14618843	0.14	FAM107B	family with sequence similarity 107, member B	4403	0.28
chr15_94815185_94815463	0.14	MCTP2	multiple C2 domains, transmembrane 2	26106	0.28
chr2_97620034_97620317	0.14	ENSG00000252845	.	2377	0.24
chr2_8616066_8616523	0.14	AC011747.7		199602	0.03
chr1_89751943_89752616	0.14	GBP5	guanylate binding protein 5	13735	0.19
chr7_114567304_114567455	0.14	MDFIC	MyoD family inhibitor domain containing	4248	0.36
chr12_46607511_46607662	0.14	SLC38A1	solute carrier family 38, member 1	53898	0.17
chr2_58136289_58136440	0.13	VRK2	vaccinia related kinase 2	1578	0.56
chr9_4598144_4598295	0.13	SLC1A1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	25884	0.18
chr14_68734669_68735014	0.13	ENSG00000243546	.	31585	0.22
chr18_2950520_2950671	0.13	RP11-737O24.2		2256	0.25
chr2_144990703_144990900	0.13	GTDC1	glycosyltransferase-like domain containing 1	2503	0.44
chr11_116796998_116797221	0.13	SIK3	SIK family kinase 3	30651	0.13
chr1_158905295_158905446	0.13	PYHIN1	pyrin and HIN domain family, member 1	4012	0.26
chr12_12679407_12679558	0.13	DUSP16	dual specificity phosphatase 16	5423	0.27
chr1_90186329_90186568	0.13	ENSG00000239176	.	47429	0.13
chr1_117311065_117311639	0.13	CD2	CD2 molecule	14263	0.21
chr3_46031859_46032010	0.13	FYCO1	FYVE and coiled-coil domain containing 1	5373	0.2
chr11_58329457_58329608	0.13	LPXN	leupaxin	13802	0.15
chr8_131255625_131255776	0.13	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	3588	0.34
chr12_76941839_76941990	0.13	OSBPL8	oxysterol binding protein-like 8	11370	0.3
chr6_112310464_112310615	0.13	WISP3	WNT1 inducible signaling pathway protein 3	64736	0.11
chr7_8022696_8022847	0.13	AC006042.7		13237	0.18
chr6_130923499_130923650	0.13	ENSG00000202438	.	28317	0.25
chr1_183444780_183444944	0.13	SMG7	SMG7 nonsense mediated mRNA decay factor	2795	0.29
chr20_47786456_47786607	0.13	STAU1	staufen double-stranded RNA binding protein 1	4269	0.24
chr22_42623963_42624114	0.13	TCF20	transcription factor 20 (AR1)	12590	0.19
chr10_32619705_32619856	0.13	RP11-135A24.4		15647	0.13
chr2_148053777_148053928	0.13	ENSG00000238860	.	27687	0.24
chr2_202093371_202093641	0.13	CASP8	caspase 8, apoptosis-related cysteine peptidase	4660	0.21
chr18_2961462_2961796	0.13	RP11-737O24.1		5387	0.16
chr3_107672504_107672666	0.13	CD47	CD47 molecule	104623	0.08
chr16_16053619_16053929	0.13	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	10340	0.22
chr13_100033049_100033200	0.13	ENSG00000207719	.	24739	0.18
chr14_68752319_68752470	0.13	ENSG00000243546	.	49138	0.17
chr1_160676517_160676733	0.13	CD48	CD48 molecule	4968	0.18
chr7_150453228_150453688	0.13	GIMAP5	GTPase, IMAP family member 5	19022	0.14
chr11_88579489_88579640	0.13	GRM5	glutamate receptor, metabotropic 5	200974	0.03
chr12_55364288_55364490	0.13	TESPA1	thymocyte expressed, positive selection associated 1	2949	0.31
chr3_111854142_111854385	0.13	RP11-757F18.5		1993	0.26
chr2_191280247_191280414	0.13	MFSD6	major facilitator superfamily domain containing 6	7249	0.21
chr5_79436518_79436669	0.13	CTC-458I2.2		12409	0.21
chr2_224822884_224823038	0.13	MRPL44	mitochondrial ribosomal protein L44	840	0.61
chr10_104685349_104685500	0.13	CNNM2	cyclin M2	7310	0.19
chr4_4527024_4527175	0.13	STX18	syntaxin 18	16638	0.19
chr15_85240505_85240759	0.13	RP11-245C17.2		11517	0.12
chr2_16106193_16106413	0.13	ENSG00000243541	.	15200	0.18
chr20_5717080_5717231	0.13	C20orf196	chromosome 20 open reading frame 196	13884	0.26
chr10_112000954_112001185	0.13	MXI1	MAX interactor 1, dimerization protein	13632	0.21
chr1_121311422_121311588	0.13	FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)	375568	0.01
chr4_102204361_102204644	0.12	ENSG00000221265	.	47069	0.15
chr3_12601064_12601266	0.12	MKRN2	makorin ring finger protein 2	2576	0.21
chr4_140150628_140150779	0.12	ENSG00000252362	.	1570	0.3
chr12_8861700_8861896	0.12	RIMKLB	ribosomal modification protein rimK-like family member B	9356	0.17
chr9_80730925_80731076	0.12	ENSG00000222452	.	49381	0.17
chr9_21331248_21331399	0.12	KLHL9	kelch-like family member 9	3917	0.16
chr12_40004458_40004609	0.12	ABCD2	ATP-binding cassette, sub-family D (ALD), member 2	9020	0.24
chr4_122836640_122836791	0.12	TRPC3	transient receptor potential cation channel, subfamily C, member 3	17478	0.21
chr6_6609840_6610222	0.12	LY86-AS1	LY86 antisense RNA 1	12897	0.24
chr15_31134475_31134626	0.12	ENSG00000221379	.	41041	0.12
chr10_8130727_8131157	0.12	GATA3	GATA binding protein 3	34173	0.24
chr15_52860223_52860374	0.12	ARPP19	cAMP-regulated phosphoprotein, 19kDa	731	0.65
chr6_99938487_99938691	0.12	USP45	ubiquitin specific peptidase 45	7848	0.18
chr2_55278350_55278727	0.12	RTN4	reticulon 4	574	0.78
chr3_197317837_197317988	0.12	BDH1	3-hydroxybutyrate dehydrogenase, type 1	17718	0.2
chr22_40314840_40314991	0.12	GRAP2	GRB2-related adaptor protein 2	7680	0.18
chr10_22938945_22939188	0.12	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	58424	0.15
chr3_152018760_152019009	0.12	MBNL1	muscleblind-like splicing regulator 1	897	0.64
chrY_1549050_1549214	0.12	NA	NA	> 10⁶	NA
chrX_1599047_1599214	0.12	ASMTL	acetylserotonin O-methyltransferase-like	26475	0.16
chr1_167407962_167408153	0.12	RP11-104L21.2		19841	0.19
chr2_235204073_235204224	0.12	ARL4C	ADP-ribosylation factor-like 4C	201096	0.03
chr18_51745857_51746008	0.12	ENSG00000207233	.	2850	0.28
chr2_99345745_99345966	0.12	MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	856	0.67
chr2_149481240_149481391	0.12	EPC2	enhancer of polycomb homolog 2 (Drosophila)	33532	0.21
chr7_117827399_117827550	0.12	NAA38	N(alpha)-acetyltransferase 38, NatC auxiliary subunit	3253	0.34
chr1_167434236_167434536	0.12	RP11-104L21.2		6488	0.23
chr13_80024271_80024542	0.12	NDFIP2	Nedd4 family interacting protein 2	30881	0.15
chr20_5565865_5566016	0.12	GPCPD1	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	9786	0.26
chr5_35671011_35671203	0.12	SPEF2	sperm flagellar 2	4597	0.28
chr11_96064460_96064611	0.12	ENSG00000266192	.	10067	0.2
chr18_67566005_67566307	0.12	CD226	CD226 molecule	48499	0.18
chr2_97477573_97477724	0.12	CNNM3	cyclin M3	4334	0.15
chr8_98697623_98697774	0.12	MTDH	metadherin	5661	0.27
chr14_91876116_91876296	0.12	CCDC88C	coiled-coil domain containing 88C	7484	0.25
chr11_95949552_95949826	0.12	ENSG00000266192	.	124913	0.05
chr5_55773462_55773845	0.12	CTC-236F12.4	Uncharacterized protein	3943	0.25
chr19_36420808_36421170	0.12	LRFN3	leucine rich repeat and fibronectin type III domain containing 3	5463	0.1
chrX_15773519_15773681	0.12	CA5B	carbonic anhydrase VB, mitochondrial	5507	0.2
chr9_100692681_100693016	0.12	C9orf156	chromosome 9 open reading frame 156	7996	0.15
chr6_34283479_34283630	0.12	C6orf1	chromosome 6 open reading frame 1	66307	0.09
chr2_235125609_235126070	0.12	SPP2	secreted phosphoprotein 2, 24kDa	166408	0.04
chr2_62445208_62445359	0.12	B3GNT2	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	2630	0.25
chr17_46435794_46435945	0.12	RP11-433M22.1		21863	0.14
chr7_36820218_36820369	0.12	AOAH	acyloxyacyl hydrolase (neutrophil)	56139	0.13
chr16_79124068_79124219	0.12	RP11-556H2.3		196	0.94
chr13_99931416_99931591	0.12	GPR18	G protein-coupled receptor 18	17505	0.18
chr5_170740649_170740930	0.12	TLX3	T-cell leukemia homeobox 3	4501	0.2
chr14_104113341_104113492	0.12	KLC1	kinesin light chain 1	17782	0.09
chr7_130701521_130701683	0.12	LINC-PINT	long intergenic non-protein coding RNA, p53 induced transcript	32734	0.18
chr3_43043421_43043572	0.12	FAM198A	family with sequence similarity 198, member A	22456	0.17
chr1_182555451_182555602	0.12	RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	582	0.78

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC10_HOXD13

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.3	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.3	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1	0.3	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.3	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.2	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.5	GO:0006491	N-glycan processing(GO:0006491)
0.1	0.2	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.1	0.2	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.1	0.2	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.1	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1	0.2	GO:0002664	T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.1	0.5	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1	0.3	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.1	0.2	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.2	GO:0002335	mature B cell differentiation(GO:0002335)
0.1	0.2	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.1	0.3	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.1	0.1	GO:0002507	tolerance induction(GO:0002507)
0.1	0.2	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.2	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.2	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.2	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.6	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.3	GO:0050856	regulation of T cell receptor signaling pathway(GO:0050856)
0.0	0.1	GO:0042510	regulation of tyrosine phosphorylation of Stat1 protein(GO:0042510)
0.0	0.1	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.0	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.2	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	1.9	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0032875	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.2	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0045354	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.2	GO:0048679	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:0001779	natural killer cell differentiation(GO:0001779)
0.0	0.2	GO:0032733	regulation of interleukin-10 production(GO:0032653) positive regulation of interleukin-10 production(GO:0032733)
0.0	0.2	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	0.1	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0070266	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.1	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0030581	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.0	GO:0071224	cellular response to peptidoglycan(GO:0071224)
0.0	0.1	GO:0071922	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.1	GO:0002836	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0	0.2	GO:0070723	response to sterol(GO:0036314) response to cholesterol(GO:0070723)
0.0	0.2	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.0	0.1	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.2	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.3	GO:0060330	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.3	GO:0060324	face development(GO:0060324)
0.0	0.1	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065) UDP-glucuronate metabolic process(GO:0046398)
0.0	0.1	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.0	GO:0046958	nonassociative learning(GO:0046958)
0.0	0.1	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.0	GO:0002643	regulation of tolerance induction(GO:0002643) positive regulation of tolerance induction(GO:0002645)
0.0	0.1	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.1	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.1	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0007097	nuclear migration(GO:0007097)
0.0	0.0	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0032814	regulation of natural killer cell activation(GO:0032814)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.1	GO:0045954	positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0045910	negative regulation of DNA recombination(GO:0045910)
0.0	0.0	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.0	GO:0010533	regulation of activation of Janus kinase activity(GO:0010533) positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	0.1	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.2	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0	0.1	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.0	GO:0010988	regulation of low-density lipoprotein particle clearance(GO:0010988)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.1	GO:0001913	T cell mediated cytotoxicity(GO:0001913) regulation of T cell mediated cytotoxicity(GO:0001914)
0.0	0.0	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.0	GO:0010587	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.2	GO:0045022	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.2	GO:0044409	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.0	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.1	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.1	GO:0033261	obsolete regulation of S phase(GO:0033261)
0.0	0.0	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.0	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.0	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.0	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.2	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.0	GO:0031054	pre-miRNA processing(GO:0031054)
0.0	0.0	GO:0021860	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.0	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.0	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.0	GO:0042253	granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253) regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.1	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein(GO:0042523)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.1	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.1	GO:0015074	DNA integration(GO:0015074)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.0	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.0	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.0	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.0	GO:0052255	modulation by symbiont of host defense response(GO:0052031) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553)
0.0	0.0	GO:0009180	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.0	GO:0035066	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.0	GO:0002921	negative regulation of humoral immune response(GO:0002921)
0.0	0.0	GO:1903313	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.0	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.0	GO:0032613	interleukin-10 production(GO:0032613)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.1	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.0	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.0	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.0	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.0	GO:0007343	egg activation(GO:0007343)
0.0	0.1	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.0	GO:0045842	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0	0.1	GO:0048194	COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.2	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.0	GO:0051533	positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0	0.0	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.0	GO:0001821	histamine secretion(GO:0001821)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.0	GO:0032292	myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.1	GO:0070265	necrotic cell death(GO:0070265)
0.0	0.0	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.0	GO:0042516	regulation of tyrosine phosphorylation of Stat3 protein(GO:0042516)
0.0	0.0	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0050851	antigen receptor-mediated signaling pathway(GO:0050851)
0.0	0.0	GO:0007042	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.0	GO:0060206	estrous cycle phase(GO:0060206)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.0	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.1	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.0	GO:0070245	positive regulation of T cell apoptotic process(GO:0070234) positive regulation of thymocyte apoptotic process(GO:0070245)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.2	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	0.5	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.1	0.6	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.2	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.2	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.0	GO:0000125	PCAF complex(GO:0000125)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.3	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.0	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.0	GO:0032009	early phagosome(GO:0032009)
0.0	0.0	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.2	GO:0030914	STAGA complex(GO:0030914)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.2	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.2	GO:0042627	chylomicron(GO:0042627)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.1	GO:0044453	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.2	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	0.1	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0	0.2	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.0	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.0	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0045120	pronucleus(GO:0045120)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.2	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.0	GO:0000791	euchromatin(GO:0000791)
0.0	0.1	GO:0032838	cell projection cytoplasm(GO:0032838)
0.0	0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.0	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.0	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.0	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.2	GO:0033691	sialic acid binding(GO:0033691)
0.1	0.2	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.2	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	0.2	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.4	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.2	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0010861	thyroid hormone receptor activator activity(GO:0010861)
0.0	0.4	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.8	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.2	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.2	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.7	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.0	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.2	GO:0005283	sodium:amino acid symporter activity(GO:0005283)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.2	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.5	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.1	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.0	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.2	GO:0016274	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.1	GO:0051998	carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.6	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.2	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.1	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.1	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.1	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.0	GO:0000739	obsolete DNA strand annealing activity(GO:0000739)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.4	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.0	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.0	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.7	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.0	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.0	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	0.0	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.5	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.0	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.0	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.2	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.0	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.0	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.2	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.0	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.0	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.4	GO:0003823	antigen binding(GO:0003823)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.0	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.0	0.0	GO:0034452	dynactin binding(GO:0034452)
0.0	0.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.0	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.0	GO:0046625	sphingolipid binding(GO:0046625)
0.0	0.0	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.2	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.1	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.0	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.0	GO:0045309	protein phosphorylated amino acid binding(GO:0045309)
0.0	0.0	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.2	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	0.0	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0004952	dopamine neurotransmitter receptor activity(GO:0004952)
0.0	0.3	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.0	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
2.5	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.7	PID CD40 PATHWAY	CD40/CD40L signaling
0.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.6	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	PID S1P S1P1 PATHWAY	S1P1 pathway
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.7	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.3	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.8	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.4	PID BCR 5PATHWAY	BCR signaling pathway
0.3	PID MYC PATHWAY	C-MYC pathway
0.1	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.2	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.2	PID ARF 3PATHWAY	Arf1 pathway
0.2	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	PID ALK2 PATHWAY	ALK2 signaling events
0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.2	PID ARF6 PATHWAY	Arf6 signaling events
0.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.4	PID PLK1 PATHWAY	PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	0.8	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	0.6	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	0.8	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.4	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.9	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.1	REACTOME AQUAPORIN MEDIATED TRANSPORT	Genes involved in Aquaporin-mediated transport
0.0	0.0	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.5	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.2	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.3	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.0	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.0	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.1	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.4	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.3	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.1	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.3	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.1	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.2	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.3	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.0	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.2	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.2	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.3	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.1	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.1	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.1	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.0	0.2	REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.0	0.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.2	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	0.1	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation