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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for HOXC10_HOXD13

Z-value: 0.71

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Transcription factors associated with HOXC10_HOXD13

Gene Symbol Gene ID Gene Info
ENSG00000180818.4 homeobox C10
ENSG00000128714.5 homeobox D13

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr12_54378978_54379226HOXC101320.523416-0.363.4e-01Click!
chr2_176953314_176953465HOXD1342300.1011430.732.7e-02Click!
chr2_176958437_176958600HOXD138990.3558880.531.4e-01Click!
chr2_176957910_176958434HOXD135530.559704-0.383.1e-01Click!
chr2_176956847_176957065HOXD136630.4848310.284.6e-01Click!
chr2_176953141_176953292HOXD1344030.0997350.255.1e-01Click!

Activity of the HOXC10_HOXD13 motif across conditions

Conditions sorted by the z-value of the HOXC10_HOXD13 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr2_198060963_198061183 0.33 AC013264.2

1642
0.33
chr12_837359_837675 0.30 WNK1
WNK lysine deficient protein kinase 1
24242
0.18
chr15_60828599_60828948 0.26 CTD-2501E16.2

6601
0.21
chr3_71461863_71462033 0.25 FOXP1
forkhead box P1
108037
0.07
chr5_100224229_100224437 0.23 ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
14585
0.28
chr13_77882140_77882385 0.22 MYCBP2
MYC binding protein 2, E3 ubiquitin protein ligase
18552
0.28
chr1_184718801_184718952 0.22 EDEM3
ER degradation enhancer, mannosidase alpha-like 3
4825
0.26
chr6_112035271_112035422 0.21 FYN
FYN oncogene related to SRC, FGR, YES
5919
0.26
chr3_141270944_141271180 0.21 RASA2-IT1
RASA2 intronic transcript 1 (non-protein coding)
27087
0.21
chr9_98486374_98486879 0.21 DKFZP434H0512
Protein LOC100506667; Putative uncharacterized protein DKFZp434H0512
47979
0.17
chr17_46375004_46375203 0.21 AC090627.1

3366
0.23
chr1_100847278_100847500 0.20 ENSG00000216067
.
3058
0.27
chr1_86854784_86854976 0.20 ODF2L
outer dense fiber of sperm tails 2-like
6001
0.25
chr11_88576113_88576264 0.20 GRM5
glutamate receptor, metabotropic 5
204350
0.03
chr1_116931483_116931823 0.19 AL136376.1
Uncharacterized protein
4935
0.17
chr4_139937547_139937724 0.19 CCRN4L
CCR4 carbon catabolite repression 4-like (S. cerevisiae)
692
0.51
chr2_198100640_198101238 0.19 ANKRD44
ankyrin repeat domain 44
38177
0.14
chr3_53069303_53069506 0.19 SFMBT1
Scm-like with four mbt domains 1
9877
0.18
chr7_105348761_105348986 0.18 ATXN7L1
ataxin 7-like 1
16789
0.26
chr2_135014379_135014599 0.18 MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
2659
0.35
chr14_73610281_73610452 0.18 PSEN1
presenilin 1
3834
0.24
chr13_31201174_31201431 0.18 USPL1
ubiquitin specific peptidase like 1
9382
0.23
chr4_110612664_110612815 0.17 AC004067.5

421
0.84
chr8_126950940_126951091 0.17 ENSG00000206695
.
37820
0.23
chr16_57021435_57021712 0.17 NLRC5
NLR family, CARD domain containing 5
1837
0.25
chr10_63998636_63998943 0.17 RTKN2
rhotekin 2
2767
0.38
chr14_99647139_99647315 0.17 AL162151.4

22474
0.23
chr3_18784592_18784781 0.17 ENSG00000228956
.
2550
0.44
chr2_101918683_101918948 0.17 RNF149
ring finger protein 149
6343
0.18
chr8_125490405_125490556 0.17 RNF139
ring finger protein 139
3501
0.2
chr2_48543908_48544266 0.16 FOXN2
forkhead box N2
2238
0.35
chr14_62265738_62265889 0.16 SNAPC1
small nuclear RNA activating complex, polypeptide 1, 43kDa
36738
0.21
chr16_17397269_17397420 0.16 XYLT1
xylosyltransferase I
167394
0.04
chr2_109582380_109582745 0.16 EDAR
ectodysplasin A receptor
23163
0.25
chrX_135710444_135710648 0.16 ENSG00000233093
.
11156
0.16
chr20_52490835_52490986 0.16 AC005220.3

65789
0.13
chr2_158269106_158269275 0.16 CYTIP
cytohesin 1 interacting protein
26736
0.19
chr16_53498380_53498624 0.16 RBL2
retinoblastoma-like 2 (p130)
14514
0.15
chr7_105515189_105515340 0.16 ATXN7L1
ataxin 7-like 1
1659
0.51
chr4_143621409_143621560 0.16 INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
139662
0.05
chr15_60085307_60085458 0.16 BNIP2
BCL2/adenovirus E1B 19kDa interacting protein 2
103649
0.06
chr2_143888983_143889411 0.16 ARHGAP15
Rho GTPase activating protein 15
2314
0.39
chr4_47829221_47829372 0.16 CORIN
corin, serine peptidase
10670
0.21
chr4_74117360_74117511 0.16 ANKRD17
ankyrin repeat domain 17
6604
0.19
chr4_73953344_73953495 0.16 COX18
COX18 cytochrome C oxidase assembly factor
17961
0.23
chr6_35566907_35567293 0.16 ENSG00000212579
.
52495
0.1
chr6_52151518_52151818 0.16 MCM3
minichromosome maintenance complex component 3
2033
0.36
chr1_151133033_151133283 0.16 SCNM1
sodium channel modifier 1
4018
0.1
chr2_197014969_197015443 0.16 RP11-347P5.1

781
0.66
chr2_204812325_204812548 0.15 ICOS
inducible T-cell co-stimulator
10933
0.28
chr7_142500387_142500538 0.15 PRSS3P2
protease, serine, 3 pseudogene 2
19331
0.16
chr17_40750860_40751042 0.15 FAM134C
family with sequence similarity 134, member C
10431
0.08
chr4_78726314_78726465 0.15 CNOT6L
CCR4-NOT transcription complex, subunit 6-like
13828
0.26
chr10_134069250_134069918 0.15 STK32C
serine/threonine kinase 32C
51134
0.12
chr12_121323357_121323508 0.15 SPPL3
signal peptide peptidase like 3
17741
0.17
chr8_82011673_82011842 0.15 PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
12546
0.28
chr11_96023136_96023287 0.15 ENSG00000266192
.
51391
0.14
chr12_47710625_47710974 0.15 ENSG00000199566
.
29281
0.17
chr1_66831872_66832123 0.15 PDE4B
phosphodiesterase 4B, cAMP-specific
11932
0.3
chr2_204596528_204596679 0.15 CD28
CD28 molecule
25187
0.19
chr3_151911039_151911356 0.15 MBNL1
muscleblind-like splicing regulator 1
74632
0.11
chr11_10819600_10819751 0.15 EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
2354
0.19
chr2_32036582_32036828 0.15 ENSG00000238448
.
1348
0.49
chr6_109357989_109358140 0.15 ENSG00000199944
.
22753
0.16
chr15_38904317_38904468 0.15 RASGRP1
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
46616
0.14
chr2_192505177_192505550 0.15 NABP1
nucleic acid binding protein 1
37499
0.21
chr3_107697281_107697722 0.15 CD47
CD47 molecule
79707
0.11
chr8_48594509_48594782 0.15 ENSG00000207369
.
14312
0.19
chr4_100765453_100765604 0.15 DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
27525
0.18
chr5_59892964_59893115 0.15 DEPDC1B
DEP domain containing 1B
102922
0.07
chr1_160682851_160683057 0.15 CD48
CD48 molecule
1313
0.4
chr1_171470969_171471120 0.15 ENSG00000239373
.
9494
0.15
chr20_51025367_51025552 0.15 ZFP64
ZFP64 zinc finger protein
216934
0.02
chrX_123476453_123476604 0.15 SH2D1A
SH2 domain containing 1A
3666
0.37
chr8_29964950_29965250 0.15 LEPROTL1
leptin receptor overlapping transcript-like 1
5644
0.16
chr14_98606379_98606534 0.15 C14orf64
chromosome 14 open reading frame 64
161995
0.04
chr1_92942408_92942722 0.14 GFI1
growth factor independent 1 transcription repressor
6946
0.27
chr2_198150239_198150434 0.14 ANKRD44-IT1
ANKRD44 intronic transcript 1 (non-protein coding)
16907
0.16
chr14_38540644_38540853 0.14 CTD-2058B24.2

19615
0.24
chr15_60843099_60843250 0.14 CTD-2501E16.2

21002
0.18
chr9_97347238_97347389 0.14 FBP2
fructose-1,6-bisphosphatase 2
8762
0.24
chrX_56594702_56594894 0.14 UBQLN2
ubiquilin 2
4772
0.35
chr4_114614482_114614847 0.14 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
67560
0.14
chr3_56729846_56730094 0.14 FAM208A
family with sequence similarity 208, member A
12705
0.27
chr15_81586884_81587161 0.14 IL16
interleukin 16
2232
0.32
chr2_99278059_99278217 0.14 MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
1798
0.39
chr11_14721093_14721244 0.14 PDE3B
phosphodiesterase 3B, cGMP-inhibited
55791
0.14
chr6_16420917_16421068 0.14 ENSG00000265642
.
7762
0.31
chr19_2850075_2850226 0.14 AC006130.3

8564
0.1
chr1_226067346_226067612 0.14 TMEM63A
transmembrane protein 63A
2100
0.22
chr1_198578902_198579207 0.14 PTPRC
protein tyrosine phosphatase, receptor type, C
28747
0.21
chr3_71127524_71127675 0.14 FOXP1
forkhead box P1
12681
0.31
chr9_2053303_2053454 0.14 RP11-264I13.2

7355
0.25
chr6_135333699_135333925 0.14 HBS1L
HBS1-like (S. cerevisiae)
14482
0.21
chr6_108958559_108958710 0.14 FOXO3
forkhead box O3
18915
0.27
chr8_20131803_20131954 0.14 ENSG00000253733
.
15807
0.18
chr12_55129725_55129876 0.14 DCD
dermcidin
87523
0.07
chr6_149793703_149793934 0.14 ZC3H12D
zinc finger CCCH-type containing 12D
10451
0.17
chr10_14618640_14618843 0.14 FAM107B
family with sequence similarity 107, member B
4403
0.28
chr15_94815185_94815463 0.14 MCTP2
multiple C2 domains, transmembrane 2
26106
0.28
chr2_97620034_97620317 0.14 ENSG00000252845
.
2377
0.24
chr2_8616066_8616523 0.14 AC011747.7

199602
0.03
chr1_89751943_89752616 0.14 GBP5
guanylate binding protein 5
13735
0.19
chr7_114567304_114567455 0.14 MDFIC
MyoD family inhibitor domain containing
4248
0.36
chr12_46607511_46607662 0.14 SLC38A1
solute carrier family 38, member 1
53898
0.17
chr2_58136289_58136440 0.13 VRK2
vaccinia related kinase 2
1578
0.56
chr9_4598144_4598295 0.13 SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
25884
0.18
chr14_68734669_68735014 0.13 ENSG00000243546
.
31585
0.22
chr18_2950520_2950671 0.13 RP11-737O24.2

2256
0.25
chr2_144990703_144990900 0.13 GTDC1
glycosyltransferase-like domain containing 1
2503
0.44
chr11_116796998_116797221 0.13 SIK3
SIK family kinase 3
30651
0.13
chr1_158905295_158905446 0.13 PYHIN1
pyrin and HIN domain family, member 1
4012
0.26
chr12_12679407_12679558 0.13 DUSP16
dual specificity phosphatase 16
5423
0.27
chr1_90186329_90186568 0.13 ENSG00000239176
.
47429
0.13
chr1_117311065_117311639 0.13 CD2
CD2 molecule
14263
0.21
chr3_46031859_46032010 0.13 FYCO1
FYVE and coiled-coil domain containing 1
5373
0.2
chr11_58329457_58329608 0.13 LPXN
leupaxin
13802
0.15
chr8_131255625_131255776 0.13 ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
3588
0.34
chr12_76941839_76941990 0.13 OSBPL8
oxysterol binding protein-like 8
11370
0.3
chr6_112310464_112310615 0.13 WISP3
WNT1 inducible signaling pathway protein 3
64736
0.11
chr7_8022696_8022847 0.13 AC006042.7

13237
0.18
chr6_130923499_130923650 0.13 ENSG00000202438
.
28317
0.25
chr1_183444780_183444944 0.13 SMG7
SMG7 nonsense mediated mRNA decay factor
2795
0.29
chr20_47786456_47786607 0.13 STAU1
staufen double-stranded RNA binding protein 1
4269
0.24
chr22_42623963_42624114 0.13 TCF20
transcription factor 20 (AR1)
12590
0.19
chr10_32619705_32619856 0.13 RP11-135A24.4

15647
0.13
chr2_148053777_148053928 0.13 ENSG00000238860
.
27687
0.24
chr2_202093371_202093641 0.13 CASP8
caspase 8, apoptosis-related cysteine peptidase
4660
0.21
chr18_2961462_2961796 0.13 RP11-737O24.1

5387
0.16
chr3_107672504_107672666 0.13 CD47
CD47 molecule
104623
0.08
chr16_16053619_16053929 0.13 ABCC1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
10340
0.22
chr13_100033049_100033200 0.13 ENSG00000207719
.
24739
0.18
chr14_68752319_68752470 0.13 ENSG00000243546
.
49138
0.17
chr1_160676517_160676733 0.13 CD48
CD48 molecule
4968
0.18
chr7_150453228_150453688 0.13 GIMAP5
GTPase, IMAP family member 5
19022
0.14
chr11_88579489_88579640 0.13 GRM5
glutamate receptor, metabotropic 5
200974
0.03
chr12_55364288_55364490 0.13 TESPA1
thymocyte expressed, positive selection associated 1
2949
0.31
chr3_111854142_111854385 0.13 RP11-757F18.5

1993
0.26
chr2_191280247_191280414 0.13 MFSD6
major facilitator superfamily domain containing 6
7249
0.21
chr5_79436518_79436669 0.13 CTC-458I2.2

12409
0.21
chr2_224822884_224823038 0.13 MRPL44
mitochondrial ribosomal protein L44
840
0.61
chr10_104685349_104685500 0.13 CNNM2
cyclin M2
7310
0.19
chr4_4527024_4527175 0.13 STX18
syntaxin 18
16638
0.19
chr15_85240505_85240759 0.13 RP11-245C17.2

11517
0.12
chr2_16106193_16106413 0.13 ENSG00000243541
.
15200
0.18
chr20_5717080_5717231 0.13 C20orf196
chromosome 20 open reading frame 196
13884
0.26
chr10_112000954_112001185 0.13 MXI1
MAX interactor 1, dimerization protein
13632
0.21
chr1_121311422_121311588 0.13 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
375568
0.01
chr4_102204361_102204644 0.12 ENSG00000221265
.
47069
0.15
chr3_12601064_12601266 0.12 MKRN2
makorin ring finger protein 2
2576
0.21
chr4_140150628_140150779 0.12 ENSG00000252362
.
1570
0.3
chr12_8861700_8861896 0.12 RIMKLB
ribosomal modification protein rimK-like family member B
9356
0.17
chr9_80730925_80731076 0.12 ENSG00000222452
.
49381
0.17
chr9_21331248_21331399 0.12 KLHL9
kelch-like family member 9
3917
0.16
chr12_40004458_40004609 0.12 ABCD2
ATP-binding cassette, sub-family D (ALD), member 2
9020
0.24
chr4_122836640_122836791 0.12 TRPC3
transient receptor potential cation channel, subfamily C, member 3
17478
0.21
chr6_6609840_6610222 0.12 LY86-AS1
LY86 antisense RNA 1
12897
0.24
chr15_31134475_31134626 0.12 ENSG00000221379
.
41041
0.12
chr10_8130727_8131157 0.12 GATA3
GATA binding protein 3
34173
0.24
chr15_52860223_52860374 0.12 ARPP19
cAMP-regulated phosphoprotein, 19kDa
731
0.65
chr6_99938487_99938691 0.12 USP45
ubiquitin specific peptidase 45
7848
0.18
chr2_55278350_55278727 0.12 RTN4
reticulon 4
574
0.78
chr3_197317837_197317988 0.12 BDH1
3-hydroxybutyrate dehydrogenase, type 1
17718
0.2
chr22_40314840_40314991 0.12 GRAP2
GRB2-related adaptor protein 2
7680
0.18
chr10_22938945_22939188 0.12 PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
58424
0.15
chr3_152018760_152019009 0.12 MBNL1
muscleblind-like splicing regulator 1
897
0.64
chrY_1549050_1549214 0.12 NA
NA
> 106
NA
chrX_1599047_1599214 0.12 ASMTL
acetylserotonin O-methyltransferase-like
26475
0.16
chr1_167407962_167408153 0.12 RP11-104L21.2

19841
0.19
chr2_235204073_235204224 0.12 ARL4C
ADP-ribosylation factor-like 4C
201096
0.03
chr18_51745857_51746008 0.12 ENSG00000207233
.
2850
0.28
chr2_99345745_99345966 0.12 MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
856
0.67
chr2_149481240_149481391 0.12 EPC2
enhancer of polycomb homolog 2 (Drosophila)
33532
0.21
chr7_117827399_117827550 0.12 NAA38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
3253
0.34
chr1_167434236_167434536 0.12 RP11-104L21.2

6488
0.23
chr13_80024271_80024542 0.12 NDFIP2
Nedd4 family interacting protein 2
30881
0.15
chr20_5565865_5566016 0.12 GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
9786
0.26
chr5_35671011_35671203 0.12 SPEF2
sperm flagellar 2
4597
0.28
chr11_96064460_96064611 0.12 ENSG00000266192
.
10067
0.2
chr18_67566005_67566307 0.12 CD226
CD226 molecule
48499
0.18
chr2_97477573_97477724 0.12 CNNM3
cyclin M3
4334
0.15
chr8_98697623_98697774 0.12 MTDH
metadherin
5661
0.27
chr14_91876116_91876296 0.12 CCDC88C
coiled-coil domain containing 88C
7484
0.25
chr11_95949552_95949826 0.12 ENSG00000266192
.
124913
0.05
chr5_55773462_55773845 0.12 CTC-236F12.4
Uncharacterized protein
3943
0.25
chr19_36420808_36421170 0.12 LRFN3
leucine rich repeat and fibronectin type III domain containing 3
5463
0.1
chrX_15773519_15773681 0.12 CA5B
carbonic anhydrase VB, mitochondrial
5507
0.2
chr9_100692681_100693016 0.12 C9orf156
chromosome 9 open reading frame 156
7996
0.15
chr6_34283479_34283630 0.12 C6orf1
chromosome 6 open reading frame 1
66307
0.09
chr2_235125609_235126070 0.12 SPP2
secreted phosphoprotein 2, 24kDa
166408
0.04
chr2_62445208_62445359 0.12 B3GNT2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
2630
0.25
chr17_46435794_46435945 0.12 RP11-433M22.1

21863
0.14
chr7_36820218_36820369 0.12 AOAH
acyloxyacyl hydrolase (neutrophil)
56139
0.13
chr16_79124068_79124219 0.12 RP11-556H2.3

196
0.94
chr13_99931416_99931591 0.12 GPR18
G protein-coupled receptor 18
17505
0.18
chr5_170740649_170740930 0.12 TLX3
T-cell leukemia homeobox 3
4501
0.2
chr14_104113341_104113492 0.12 KLC1
kinesin light chain 1
17782
0.09
chr7_130701521_130701683 0.12 LINC-PINT
long intergenic non-protein coding RNA, p53 induced transcript
32734
0.18
chr3_43043421_43043572 0.12 FAM198A
family with sequence similarity 198, member A
22456
0.17
chr1_182555451_182555602 0.12 RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
582
0.78

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC10_HOXD13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1 0.3 GO:0046137 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1 0.3 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1 0.3 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 0.3 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 0.2 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.1 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.2 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.1 0.2 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.1 0.2 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 0.1 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.2 GO:0002664 T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.1 0.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.3 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.1 0.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.2 GO:0002335 mature B cell differentiation(GO:0002335)
0.1 0.2 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.1 0.3 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
0.1 0.1 GO:0002507 tolerance induction(GO:0002507)
0.1 0.2 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.2 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.2 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.2 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0002890 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0 0.1 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.2 GO:0043368 positive T cell selection(GO:0043368)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.6 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.3 GO:0050856 regulation of T cell receptor signaling pathway(GO:0050856)
0.0 0.1 GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein(GO:0042510)
0.0 0.1 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.0 GO:0051665 membrane raft localization(GO:0051665)
0.0 0.1 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.2 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 1.9 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0032875 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.2 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.1 GO:0045354 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.2 GO:0048679 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.1 GO:0001779 natural killer cell differentiation(GO:0001779)
0.0 0.2 GO:0032733 regulation of interleukin-10 production(GO:0032653) positive regulation of interleukin-10 production(GO:0032733)
0.0 0.2 GO:0035246 peptidyl-arginine N-methylation(GO:0035246)
0.0 0.1 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.1 GO:0006681 galactosylceramide metabolic process(GO:0006681)
0.0 0.1 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.0 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0070266 necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0 0.1 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.1 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.0 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.0 GO:0071224 cellular response to peptidoglycan(GO:0071224)
0.0 0.1 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.1 GO:0002836 regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0 0.2 GO:0070723 response to sterol(GO:0036314) response to cholesterol(GO:0070723)
0.0 0.2 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.2 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.0 0.3 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.3 GO:0060324 face development(GO:0060324)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065) UDP-glucuronate metabolic process(GO:0046398)
0.0 0.1 GO:0008291 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0 0.0 GO:0046958 nonassociative learning(GO:0046958)
0.0 0.1 GO:0050687 negative regulation of defense response to virus(GO:0050687)
0.0 0.0 GO:0002643 regulation of tolerance induction(GO:0002643) positive regulation of tolerance induction(GO:0002645)
0.0 0.1 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 0.1 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.1 GO:0007097 nuclear migration(GO:0007097)
0.0 0.0 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.1 GO:0032814 regulation of natural killer cell activation(GO:0032814)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.0 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.0 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.1 GO:0045954 positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 0.0 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.0 0.0 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.0 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533) positive regulation of activation of Janus kinase activity(GO:0010536)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.2 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0 0.1 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0 0.1 GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0 0.0 GO:0010988 regulation of low-density lipoprotein particle clearance(GO:0010988)
0.0 0.1 GO:0090322 regulation of superoxide metabolic process(GO:0090322)
0.0 0.1 GO:0001913 T cell mediated cytotoxicity(GO:0001913) regulation of T cell mediated cytotoxicity(GO:0001914)
0.0 0.0 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.0 GO:0010587 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0 0.2 GO:0045022 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0 0.1 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.1 GO:0043628 ncRNA 3'-end processing(GO:0043628)
0.0 0.2 GO:0044409 entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0 0.0 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
0.0 0.1 GO:0032988 ribonucleoprotein complex disassembly(GO:0032988)
0.0 0.1 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.1 GO:0033261 obsolete regulation of S phase(GO:0033261)
0.0 0.0 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.0 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0 0.0 GO:0060916 mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0 0.0 GO:0046476 glycosylceramide biosynthetic process(GO:0046476)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.0 GO:0031054 pre-miRNA processing(GO:0031054)
0.0 0.0 GO:0021860 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.0 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.0 GO:0033160 positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0 0.0 GO:0042253 granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253) regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0 0.1 GO:0051642 centrosome localization(GO:0051642)
0.0 0.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 0.1 GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein(GO:0042523)
0.0 0.1 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.1 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.0 GO:0070669 response to interleukin-2(GO:0070669)
0.0 0.0 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.0 GO:0015705 iodide transport(GO:0015705)
0.0 0.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.0 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.0 GO:0052255 modulation by symbiont of host defense response(GO:0052031) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553)
0.0 0.0 GO:0009180 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0 0.0 GO:0035066 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.0 GO:0002921 negative regulation of humoral immune response(GO:0002921)
0.0 0.0 GO:1903313 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.0 GO:0097709 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.0 GO:0032613 interleukin-10 production(GO:0032613)
0.0 0.0 GO:0046877 regulation of saliva secretion(GO:0046877)
0.0 0.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.0 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.0 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.0 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.0 GO:0007343 egg activation(GO:0007343)
0.0 0.1 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.0 GO:0045842 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.1 GO:0048194 COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.0 0.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.2 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.0 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.0 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.0 GO:0001821 histamine secretion(GO:0001821)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.0 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.1 GO:0006983 ER overload response(GO:0006983)
0.0 0.1 GO:0070265 necrotic cell death(GO:0070265)
0.0 0.0 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.0 GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein(GO:0042516)
0.0 0.0 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.1 GO:0050851 antigen receptor-mediated signaling pathway(GO:0050851)
0.0 0.0 GO:0007042 lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0 0.0 GO:0060206 estrous cycle phase(GO:0060206)
0.0 0.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.0 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.0 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.0 GO:0070245 positive regulation of T cell apoptotic process(GO:0070234) positive regulation of thymocyte apoptotic process(GO:0070245)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.2 GO:0072487 MSL complex(GO:0072487)
0.1 0.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.2 GO:0042598 obsolete vesicular fraction(GO:0042598)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.0 GO:0000125 PCAF complex(GO:0000125)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.3 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.1 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.0 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.0 GO:0032009 early phagosome(GO:0032009)
0.0 0.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.2 GO:0030914 STAGA complex(GO:0030914)
0.0 0.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.0 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.0 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0 0.2 GO:0042627 chylomicron(GO:0042627)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.2 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.1 GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.0 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.0 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.1 GO:0045120 pronucleus(GO:0045120)
0.0 0.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.0 GO:0000791 euchromatin(GO:0000791)
0.0 0.1 GO:0032838 cell projection cytoplasm(GO:0032838)
0.0 0.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.0 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.0 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.0 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.2 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.2 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.2 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 0.2 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.4 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.2 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0010861 thyroid hormone receptor activator activity(GO:0010861)
0.0 0.4 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.8 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.2 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.2 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.0 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.2 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.2 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0016362 activin receptor activity, type II(GO:0016362)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.0 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.2 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0051998 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0 0.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.1 GO:0071723 lipopeptide binding(GO:0071723)
0.0 0.2 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.1 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.0 0.1 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.0 GO:0000739 obsolete DNA strand annealing activity(GO:0000739)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.0 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.0 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 0.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.0 GO:0004946 bombesin receptor activity(GO:0004946)
0.0 0.0 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.0 GO:0035197 siRNA binding(GO:0035197)
0.0 0.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.0 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.0 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.0 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0 0.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.0 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.0 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.0 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.0 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.0 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.0 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.4 GO:0003823 antigen binding(GO:0003823)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.0 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.0 0.0 GO:0034452 dynactin binding(GO:0034452)
0.0 0.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.0 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 0.0 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.0 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.0 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.0 0.0 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.2 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.0 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
0.0 0.3 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.1 GO:0030276 clathrin binding(GO:0030276)
0.0 0.0 GO:0019959 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.0 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.5 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.3 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.7 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.5 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.6 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.0 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.0 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.0 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.7 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.4 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.3 PID MYC PATHWAY C-MYC pathway
0.0 0.1 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.3 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.2 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.2 PID ARF 3PATHWAY Arf1 pathway
0.0 0.2 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.0 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.2 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.0 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.0 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.4 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 0.8 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 0.6 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 0.8 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.9 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.1 REACTOME AQUAPORIN MEDIATED TRANSPORT Genes involved in Aquaporin-mediated transport
0.0 0.0 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.0 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.0 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.1 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.4 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.1 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.0 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.0 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.2 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 0.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.1 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.1 REACTOME IL 2 SIGNALING Genes involved in Interleukin-2 signaling
0.0 0.2 REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.0 0.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.0 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.1 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation