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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HSF4

Z-value: 1.06

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Transcription factors associated with HSF4

Gene Symbol	Gene ID	Gene Info
HSF4 Ensembl NCBI GeneCards UniProt	ENSG00000102878.11	HSF4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HSF4	chr16_67203074_67203225	172	0.812528	-0.67	4.7e-02	Click!
HSF4	chr16_67196662_67196813	551	0.445907	0.61	8.0e-02	Click!
HSF4	chr16_67198740_67198891	100	0.901692	0.58	1.0e-01	Click!
HSF4	chr16_67199421_67199612	88	0.908316	0.53	1.4e-01	Click!
HSF4	chr16_67197789_67198350	646	0.420290	0.38	3.1e-01	Click!

Activity of the HSF4 motif across conditions

Conditions sorted by the z-value of the HSF4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_139312464_139312655	0.71	CLEC2L	C-type lectin domain family 2, member L	103731	0.06
chr14_99670994_99671151	0.65	AL162151.4		46319	0.15
chr7_1087128_1087349	0.65	GPR146	G protein-coupled receptor 146	3026	0.13
chr21_36340846_36341061	0.62	RUNX1	runt-related transcription factor 1	78866	0.12
chr5_156681732_156681896	0.62	CYFIP2	cytoplasmic FMR1 interacting protein 2	11277	0.13
chr7_2739468_2739742	0.60	AMZ1	archaelysin family metallopeptidase 1	11769	0.21
chr14_98657577_98657728	0.60	ENSG00000222066	.	140435	0.05
chr22_27043526_27043866	0.57	CRYBA4	crystallin, beta A4	25768	0.16
chr12_47758069_47758220	0.57	ENSG00000264906	.	92	0.98
chr5_150597516_150598012	0.57	CCDC69	coiled-coil domain containing 69	5942	0.19
chr8_37134401_37134693	0.55	RP11-150O12.6		239992	0.02
chr16_3838912_3839326	0.54	CREBBP	CREB binding protein	8251	0.23
chr1_100856884_100857083	0.54	ENSG00000216067	.	12652	0.2
chr22_40327971_40328220	0.53	GRAP2	GRB2-related adaptor protein 2	5454	0.19
chr10_14702537_14702914	0.51	ENSG00000201766	.	2768	0.28
chr13_114914753_114915138	0.51	RASA3	RAS p21 protein activator 3	16859	0.2
chr1_25350610_25350934	0.51	ENSG00000264371	.	778	0.7
chr11_128598285_128598783	0.50	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	32616	0.15
chr16_67837738_67838160	0.49	RANBP10	RAN binding protein 10	2511	0.15
chr1_118197732_118198071	0.49	ENSG00000212266	.	33463	0.17
chr1_111437508_111437815	0.48	CD53	CD53 molecule	21885	0.15
chr2_205833792_205833953	0.48	PARD3B	par-3 family cell polarity regulator beta	423149	0.01
chr22_27071165_27071316	0.48	CRYBA4	crystallin, beta A4	53312	0.12
chr8_27235111_27235488	0.47	PTK2B	protein tyrosine kinase 2 beta	2869	0.31
chr13_114912317_114912766	0.47	RASA3	RAS p21 protein activator 3	14455	0.21
chr1_24851023_24851224	0.46	ENSG00000266551	.	5081	0.18
chrX_154417614_154417799	0.46	VBP1	von Hippel-Lindau binding protein 1	7578	0.2
chr3_15332186_15332608	0.46	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	14845	0.14
chrX_64947728_64947879	0.46	MSN	moesin	60266	0.16
chr19_4084516_4084732	0.46	MAP2K2	mitogen-activated protein kinase kinase 2	16421	0.11
chr19_3757648_3757799	0.45	AC005954.3		1066	0.31
chr16_68105212_68105363	0.45	NFATC3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	13960	0.09
chr17_63025333_63025500	0.45	RP11-583F2.5		22611	0.15
chr7_50422851_50423205	0.45	IKZF1	IKAROS family zinc finger 1 (Ikaros)	55783	0.14
chr1_203255177_203255328	0.45	BTG2	BTG family, member 2	19412	0.16
chr2_62430640_62430961	0.45	ENSG00000266097	.	2161	0.29
chr9_82248211_82248468	0.45	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	19169	0.31
chr8_28917519_28917756	0.44	CTD-2647L4.4		4185	0.17
chr4_154449092_154449243	0.44	KIAA0922	KIAA0922	27881	0.22
chr12_122228197_122228738	0.44	RHOF	ras homolog family member F (in filopodia)	2799	0.22
chr15_81576710_81577129	0.44	IL16	interleukin 16	12335	0.21
chr5_169702138_169702842	0.44	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	8159	0.23
chr1_185250977_185251218	0.44	ENSG00000252612	.	15430	0.16
chr14_69280428_69280742	0.43	ZFP36L1	ZFP36 ring finger protein-like 1	17395	0.19
chr21_47972699_47973025	0.43	ENSG00000272283	.	17153	0.17
chr17_63022687_63022838	0.43	RP11-583F2.5		25265	0.14
chr8_22496270_22496646	0.43	BIN3	bridging integrator 3	5859	0.12
chr19_42399773_42399960	0.43	ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	414	0.76
chr19_3756961_3757129	0.43	AC005954.3		388	0.71
chr19_3813101_3813594	0.43	MATK	megakaryocyte-associated tyrosine kinase	11220	0.11
chr2_3225421_3225572	0.43	TSSC1-IT1	TSSC1 intronic transcript 1 (non-protein coding)	79740	0.1
chr21_45575872_45576023	0.43	AP001055.1		17633	0.13
chr14_53211245_53211397	0.43	STYX	serine/threonine/tyrosine interacting protein	14421	0.14
chr3_48551527_48551686	0.42	SHISA5	shisa family member 5	9347	0.1
chr1_117544919_117545104	0.42	CD101	CD101 molecule	577	0.73
chr1_154376165_154376624	0.42	IL6R	interleukin 6 receptor	1275	0.33
chr8_59930806_59931005	0.42	RP11-328K2.1		25408	0.23
chr11_6762047_6762301	0.42	GVINP1	GTPase, very large interferon inducible pseudogene 1	19063	0.11
chr16_79320751_79320982	0.42	ENSG00000222244	.	22515	0.27
chr2_135005025_135005319	0.42	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	6658	0.26
chr19_41850700_41850906	0.41	TGFB1	transforming growth factor, beta 1	2868	0.13
chr2_182177306_182177486	0.41	ENSG00000266705	.	7017	0.32
chr1_25421803_25422058	0.41	ENSG00000264371	.	71936	0.09
chr10_7201395_7201546	0.40	SFMBT2	Scm-like with four mbt domains 2	249237	0.02
chr22_20819732_20820026	0.40	ENSG00000255156	.	9719	0.1
chr17_55681912_55682272	0.39	RP11-118E18.4		3681	0.24
chr10_26753045_26753285	0.39	APBB1IP	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	25811	0.22
chr6_45462657_45462916	0.38	RUNX2	runt-related transcription factor 2	72564	0.11
chr5_39155242_39155486	0.38	FYB	FYN binding protein	47765	0.15
chr1_115009857_115010035	0.38	TRIM33	tripartite motif containing 33	3898	0.27
chr20_50019481_50019826	0.38	ENSG00000263645	.	25795	0.22
chr19_16379790_16380087	0.38	CTD-2562J15.6		24448	0.13
chr9_132794767_132794918	0.38	FNBP1	formin binding protein 1	10599	0.2
chr3_3213200_3213369	0.38	CRBN	cereblon	8074	0.19
chr5_151175034_151175185	0.38	ATOX1	antioxidant 1 copper chaperone	23016	0.15
chr16_85337462_85337809	0.38	ENSG00000266307	.	2296	0.37
chr6_159139178_159139369	0.37	ENSG00000265558	.	46512	0.12
chrX_6978429_6978580	0.37	ENSG00000264268	.	87397	0.09
chr1_38138940_38139091	0.37	C1orf109	chromosome 1 open reading frame 109	17161	0.12
chr22_40729451_40729738	0.37	ADSL	adenylosuccinate lyase	12913	0.18
chr6_52150845_52151081	0.37	MCM3	minichromosome maintenance complex component 3	1328	0.48
chr2_204865819_204865980	0.37	ICOS	inducible T-cell co-stimulator	64396	0.14
chr3_12991701_12991859	0.37	IQSEC1	IQ motif and Sec7 domain 1	17388	0.22
chr7_50321524_50321798	0.36	IKZF1	IKAROS family zinc finger 1 (Ikaros)	22663	0.25
chr3_105552050_105552274	0.36	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	35725	0.25
chr5_158838800_158839019	0.36	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	81014	0.09
chr3_15319262_15319413	0.36	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	1785	0.29
chr2_109225906_109226290	0.36	LIMS1	LIM and senescent cell antigen-like domains 1	2481	0.35
chr11_121452316_121452687	0.36	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	4954	0.34
chr12_6542028_6542189	0.36	CD27	CD27 molecule	11925	0.09
chr19_9972790_9973038	0.35	OLFM2	olfactomedin 2	4070	0.12
chr17_5292178_5292426	0.35	RABEP1	rabaptin, RAB GTPase binding effector protein 1	11796	0.12
chr16_68453137_68453288	0.35	SMPD3	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	29183	0.12
chr20_31555391_31555580	0.35	EFCAB8	EF-hand calcium binding domain 8	7834	0.17
chr7_21393437_21393588	0.35	ENSG00000195024	.	27469	0.2
chrX_129222828_129223069	0.35	ELF4	E74-like factor 4 (ets domain transcription factor)	21388	0.19
chr1_65528171_65528405	0.35	ENSG00000199135	.	4097	0.22
chr1_24235021_24235316	0.35	RP11-4M23.3		1567	0.24
chr11_117821389_117821783	0.35	TMPRSS13	transmembrane protease, serine 13	21412	0.15
chr4_40251320_40251540	0.35	RHOH	ras homolog family member H	49466	0.13
chr15_81593592_81593958	0.35	IL16	interleukin 16	2018	0.33
chr6_39195665_39195856	0.35	KCNK5	potassium channel, subfamily K, member 5	1466	0.51
chr6_134953210_134953361	0.35	ALDH8A1	aldehyde dehydrogenase 8 family, member A1	297014	0.01
chr1_183447249_183447596	0.34	SMG7	SMG7 nonsense mediated mRNA decay factor	5355	0.23
chr1_169672251_169672700	0.34	SELL	selectin L	8364	0.2
chr17_75959968_75960181	0.34	TNRC6C	trinucleotide repeat containing 6C	40175	0.14
chr5_35788787_35788938	0.34	SPEF2	sperm flagellar 2	9592	0.22
chr5_55351651_55351834	0.34	ENSG00000238326	.	55293	0.09
chr1_26696466_26696677	0.34	ZNF683	zinc finger protein 683	665	0.58
chr12_104880310_104880679	0.33	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	29715	0.22
chr19_10254387_10254800	0.33	EIF3G	eukaryotic translation initiation factor 3, subunit G	24015	0.07
chr4_8349309_8349460	0.33	ENSG00000202054	.	45358	0.14
chr17_75395164_75395315	0.33	SEPT9	septin 9	1401	0.34
chr9_78642998_78643161	0.33	PCSK5	proprotein convertase subtilisin/kexin type 5	67814	0.13
chr16_85768216_85768412	0.33	ENSG00000222190	.	6992	0.12
chr18_60911782_60912122	0.33	ENSG00000238988	.	50054	0.12
chr13_114991565_114991854	0.33	CDC16	cell division cycle 16	8653	0.18
chr12_121848379_121848530	0.33	RNF34	ring finger protein 34, E3 ubiquitin protein ligase	1176	0.51
chr15_26056534_26056770	0.33	ENSG00000199214	.	6478	0.21
chr9_112906499_112906706	0.32	AKAP2	A kinase (PRKA) anchor protein 2	18821	0.24
chr9_112713247_112713398	0.32	PALM2	paralemmin 2	84011	0.09
chr6_139452567_139452918	0.32	HECA	headcase homolog (Drosophila)	3507	0.32
chr10_51517238_51517411	0.32	AGAP7	ArfGAP with GTPase domain, ankyrin repeat and PH domain 7	30997	0.14
chrX_41775628_41775779	0.32	ENSG00000251807	.	2899	0.31
chr5_130597752_130597932	0.32	CDC42SE2	CDC42 small effector 2	1860	0.47
chr10_27087573_27087735	0.32	ENSG00000206605	.	8079	0.19
chr2_48078802_48078953	0.32	FBXO11	F-box protein 11	15776	0.21
chr1_226916534_226916814	0.32	ITPKB	inositol-trisphosphate 3-kinase B	8485	0.23
chr10_11213546_11213708	0.32	RP3-323N1.2		288	0.92
chr17_7456942_7457093	0.32	TNFSF12	tumor necrosis factor (ligand) superfamily, member 12	4546	0.06
chr13_77793771_77793922	0.32	MYCBP2	MYC binding protein 2, E3 ubiquitin protein ligase	106968	0.07
chr6_24955515_24955958	0.32	FAM65B	family with sequence similarity 65, member B	19548	0.21
chr5_72528452_72528679	0.32	TMEM174	transmembrane protein 174	59543	0.12
chrX_135709367_135709640	0.32	ENSG00000233093	.	12199	0.16
chr2_158750571_158750722	0.32	UPP2	uridine phosphorylase 2	17432	0.16
chr19_5077571_5077794	0.32	KDM4B	lysine (K)-specific demethylase 4B	4781	0.27
chr3_32498174_32498359	0.31	CMTM6	CKLF-like MARVEL transmembrane domain containing 6	46634	0.14
chr20_58639264_58639415	0.31	C20orf197	chromosome 20 open reading frame 197	8359	0.26
chr15_32651213_32651761	0.31	ENSG00000221444	.	34186	0.1
chr11_121332248_121332530	0.31	RP11-730K11.1		8667	0.24
chr15_59836576_59836759	0.31	ENSG00000201704	.	29754	0.14
chr22_27040755_27040920	0.31	CRYBA4	crystallin, beta A4	22909	0.17
chr1_226901230_226901381	0.31	ITPKB	inositol-trisphosphate 3-kinase B	23854	0.18
chr14_64963769_64963936	0.31	ZBTB1	zinc finger and BTB domain containing 1	6591	0.12
chr22_45068838_45068989	0.31	PRR5	proline rich 5 (renal)	4024	0.25
chr2_197015707_197015858	0.30	RP11-347P5.1		205	0.94
chr2_231521971_231522122	0.30	CAB39	calcium binding protein 39	55514	0.11
chr11_114086673_114087539	0.30	NNMT	nicotinamide N-methyltransferase	41447	0.17
chr1_231748922_231749511	0.30	LINC00582	long intergenic non-protein coding RNA 582	1380	0.44
chr1_206556159_206556344	0.30	SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	1115	0.4
chr2_12642786_12642950	0.30	ENSG00000207183	.	91241	0.1
chr6_88453159_88453310	0.30	ENSG00000238628	.	22601	0.18
chr17_47813077_47813254	0.30	FAM117A	family with sequence similarity 117, member A	11276	0.14
chr16_84628580_84628866	0.30	RP11-61F12.1		724	0.65
chr7_101385381_101385615	0.30	CUX1	cut-like homeobox 1	73461	0.1
chrX_135851684_135852073	0.30	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	1092	0.49
chr2_235335702_235336092	0.30	ARL4C	ADP-ribosylation factor-like 4C	69347	0.14
chr15_30471500_30471800	0.30	ENSG00000221785	.	34570	0.11
chr1_42123736_42123959	0.29	HIVEP3	human immunodeficiency virus type I enhancer binding protein 3	42825	0.18
chr3_15709764_15709915	0.29	ENSG00000264354	.	29039	0.15
chr2_233179198_233179349	0.29	DIS3L2	DIS3 mitotic control homolog (S. cerevisiae)-like 2	19380	0.17
chr13_28030262_28030413	0.29	MTIF3	mitochondrial translational initiation factor 3	5598	0.19
chr6_28473877_28474028	0.29	GPX6	glutathione peroxidase 6 (olfactory)	9612	0.17
chr10_115441935_115442086	0.29	CASP7	caspase 7, apoptosis-related cysteine peptidase	2311	0.29
chr1_26865494_26865771	0.29	RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	3971	0.17
chr11_95375181_95375332	0.29	FAM76B	family with sequence similarity 76, member B	144713	0.04
chr5_527247_527623	0.29	RP11-310P5.2		2615	0.18
chr19_50835735_50835918	0.29	KCNC3	potassium voltage-gated channel, Shaw-related subfamily, member 3	946	0.37
chr2_28572176_28572390	0.29	AC093690.1		38957	0.13
chr10_14698882_14699236	0.29	RP11-7C6.1		4318	0.23
chr1_779209_779379	0.29	RP11-206L10.8		33753	0.1
chr18_72075391_72075542	0.29	FAM69C	family with sequence similarity 69, member C	49037	0.14
chr10_11252452_11252842	0.29	RP3-323N1.2		39308	0.17
chr17_56456497_56456648	0.29	RNF43	ring finger protein 43	23510	0.11
chr2_13037487_13037811	0.29	ENSG00000264370	.	160156	0.04
chr3_107673374_107673767	0.29	CD47	CD47 molecule	103638	0.08
chr19_4641704_4641855	0.29	TNFAIP8L1	tumor necrosis factor, alpha-induced protein 8-like 1	1750	0.24
chr10_13160669_13160820	0.29	OPTN	optineurin	2476	0.29
chr2_241564217_241564368	0.29	GPR35	G protein-coupled receptor 35	370	0.81
chr5_156644620_156644840	0.29	CTB-4E7.1		6660	0.14
chr8_28936608_28936759	0.29	CTD-2647L4.5		11887	0.14
chr3_3233085_3233387	0.29	CRBN	cereblon	11842	0.2
chr9_92044873_92045111	0.29	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	6386	0.26
chr16_4725775_4726545	0.29	NUDT16L1	nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1	17535	0.1
chr19_42276662_42276849	0.29	AC011513.4		14046	0.12
chr7_157263857_157264008	0.29	AC006372.6		42056	0.16
chr3_18540522_18540673	0.29	ENSG00000228956	.	27291	0.22
chr2_85101975_85102126	0.29	TRABD2A	TraB domain containing 2A	6156	0.2
chr4_144441518_144441669	0.28	SMARCA5-AS1	SMARCA5 antisense RNA 1	5805	0.23
chr20_44832267_44832487	0.28	CDH22	cadherin 22, type 2	47957	0.13
chr14_99645282_99645517	0.28	AL162151.4		20646	0.24
chr1_160612345_160612670	0.28	SLAMF1	signaling lymphocytic activation molecule family member 1	4304	0.19
chr3_42388906_42389324	0.28	LYZL4	lysozyme-like 4	62935	0.1
chr1_25436980_25437131	0.28	ENSG00000264371	.	87061	0.07
chr12_133289810_133290003	0.28	PGAM5	phosphoglycerate mutase family member 5	1433	0.3
chr19_5952060_5952229	0.28	RANBP3	RAN binding protein 3	25946	0.08
chr5_118648731_118648896	0.28	ENSG00000243333	.	6487	0.21
chr14_25140513_25140664	0.28	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	37115	0.14
chr14_104858355_104858716	0.28	ENSG00000222761	.	8850	0.27
chr5_39160522_39160673	0.28	FYB	FYN binding protein	42532	0.17

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.1	0.2	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.1	0.6	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.2	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.2	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:0072600	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1	0.1	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.1	0.3	GO:0006515	misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1	0.3	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1	0.2	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.1	0.2	GO:0030952	establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.1	0.2	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.1	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0	0.3	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0002870	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.5	GO:0045061	thymic T cell selection(GO:0045061)
0.0	0.2	GO:0050685	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.0	GO:2000041	regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0	0.2	GO:0070102	interleukin-6-mediated signaling pathway(GO:0070102)
0.0	0.2	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.2	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.2	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.2	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:2000380	regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0048087	positive regulation of developmental pigmentation(GO:0048087)
0.0	0.1	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.3	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.3	GO:0002418	immune response to tumor cell(GO:0002418)
0.0	0.1	GO:0006925	inflammatory cell apoptotic process(GO:0006925)
0.0	0.0	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.0	0.9	GO:0050772	positive regulation of axonogenesis(GO:0050772)
0.0	0.1	GO:0032100	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.1	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.2	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.1	GO:1901534	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.0	GO:0019042	viral latency(GO:0019042)
0.0	0.3	GO:0006911	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.1	GO:0007343	egg activation(GO:0007343)
0.0	0.1	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.0	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.0	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.0	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.2	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.0	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.2	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.2	GO:0050684	regulation of mRNA processing(GO:0050684) regulation of mRNA metabolic process(GO:1903311)
0.0	0.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.1	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.1	GO:0002360	T cell lineage commitment(GO:0002360)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.0	GO:0045586	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.0	0.1	GO:0033033	negative regulation of myeloid cell apoptotic process(GO:0033033)
0.0	0.0	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.0	GO:0060976	coronary vasculature development(GO:0060976)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.0	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.1	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0010887	negative regulation of cholesterol storage(GO:0010887)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.0	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.0	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.0	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.1	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.0	GO:0002691	regulation of cellular extravasation(GO:0002691)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.0	GO:0001743	optic placode formation(GO:0001743)
0.0	0.1	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.0	0.0	GO:0030910	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.1	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.0	GO:0010661	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.1	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.0	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.1	GO:0048563	post-embryonic organ morphogenesis(GO:0048563)
0.0	0.0	GO:0032817	regulation of natural killer cell proliferation(GO:0032817)
0.0	0.0	GO:0051788	response to misfolded protein(GO:0051788)
0.0	0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.1	GO:1902222	L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0	0.0	GO:1904376	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.0	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0	0.0	GO:0060789	hair follicle placode formation(GO:0060789)
0.0	0.0	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.0	GO:0032212	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.0	GO:0061054	dermatome development(GO:0061054)
0.0	0.0	GO:0008615	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0000098	sulfur amino acid catabolic process(GO:0000098)
0.0	0.2	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0	0.1	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.0	0.0	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.0	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.0	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.0	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.0	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.0	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.0	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.0	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.0	GO:2000344	positive regulation of acrosome reaction(GO:2000344)
0.0	0.1	GO:0043049	otic placode formation(GO:0043049)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546)
0.0	0.2	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0043558	regulation of translational initiation in response to stress(GO:0043558)
0.0	0.0	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.2	GO:0030252	growth hormone secretion(GO:0030252)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.0	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.2	GO:0060330	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0006734	NADH metabolic process(GO:0006734)
0.0	0.1	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0	0.1	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.2	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.0	GO:0090192	regulation of glomerulus development(GO:0090192)
0.0	0.1	GO:0036230	granulocyte activation(GO:0036230)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.0	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.1	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.0	GO:0031297	replication fork processing(GO:0031297)
0.0	0.0	GO:1901984	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.0	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.1	GO:0002052	positive regulation of neuroblast proliferation(GO:0002052)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.1	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.0	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.0	GO:0010533	regulation of activation of Janus kinase activity(GO:0010533) regulation of activation of JAK2 kinase activity(GO:0010534) positive regulation of activation of JAK2 kinase activity(GO:0010535) positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	0.0	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.0	GO:1902803	regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0	0.1	GO:0060438	trachea development(GO:0060438)
0.0	0.0	GO:0051569	regulation of histone H3-K4 methylation(GO:0051569)
0.0	0.0	GO:0045634	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.0	GO:0071922	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.0	GO:0032693	negative regulation of interleukin-10 production(GO:0032693)
0.0	0.1	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0042435	indole-containing compound biosynthetic process(GO:0042435)
0.0	0.2	GO:0043526	obsolete neuroprotection(GO:0043526)
0.0	0.0	GO:0070570	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.2	GO:0097581	lamellipodium organization(GO:0097581)
0.0	0.0	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.0	GO:0017085	response to insecticide(GO:0017085)
0.0	0.1	GO:0007080	mitotic metaphase plate congression(GO:0007080)
0.0	0.1	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.0	0.1	GO:0036465	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.0	GO:0060677	ureteric bud elongation(GO:0060677)
0.0	0.0	GO:0042253	granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253) regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0	0.0	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.2	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	0.3	GO:0043218	compact myelin(GO:0043218)
0.1	0.2	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.2	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.5	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.2	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0031904	endosome lumen(GO:0031904)
0.0	0.1	GO:0070938	contractile ring(GO:0070938)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.3	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.2	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.1	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.6	GO:0009295	nucleoid(GO:0009295)
0.0	0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.0	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0033011	perinuclear theca(GO:0033011)
0.0	0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.1	GO:0043209	myelin sheath(GO:0043209)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.0	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.5	GO:0030175	filopodium(GO:0030175)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.2	GO:0035267	NuA4 histone acetyltransferase complex(GO:0035267)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0001772	immunological synapse(GO:0001772)
0.0	0.2	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.1	GO:0034518	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.0	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.0	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	0.0	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	0.0	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.1	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0	0.1	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.1	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.0	GO:0099738	cell cortex region(GO:0099738)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.1	0.2	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1	0.2	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.1	0.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.2	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.2	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.2	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.4	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.3	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.2	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.2	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.2	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.3	GO:0099604	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.5	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.4	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.0	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.2	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.4	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0	0.1	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.0	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.2	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.7	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0016715	dopamine beta-monooxygenase activity(GO:0004500) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.2	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.0	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.2	GO:0016409	palmitoyltransferase activity(GO:0016409)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.2	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.4	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.7	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.0	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.0	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.4	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0	0.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.1	GO:0016274	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.1	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.0	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.0	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0005451	monovalent cation:proton antiporter activity(GO:0005451)
0.0	0.0	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.0	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.1	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.1	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.0	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.0	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.0	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.0	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.0	GO:0046980	tapasin binding(GO:0046980)
0.0	0.0	GO:0004802	transketolase activity(GO:0004802)
0.0	0.0	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.1	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.2	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.1	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.1	GO:0015166	polyol transmembrane transporter activity(GO:0015166)
0.0	0.0	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.2	GO:0043022	ribosome binding(GO:0043022)
0.0	0.0	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.7	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
1.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.2	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
1.6	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.3	PID S1P S1P4 PATHWAY	S1P4 pathway
0.7	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.2	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.6	PID BCR 5PATHWAY	BCR signaling pathway
0.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.7	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.2	ST STAT3 PATHWAY	STAT3 Pathway
0.7	PID ILK PATHWAY	Integrin-linked kinase signaling
0.3	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.2	PID S1P S1P3 PATHWAY	S1P3 pathway
0.3	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.3	PID ARF6 PATHWAY	Arf6 signaling events
0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.3	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.3	PID IL12 2PATHWAY	IL12-mediated signaling events
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.3	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.4	PID TNF PATHWAY	TNF receptor signaling pathway
0.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.1	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	PID S1P S1P2 PATHWAY	S1P2 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.6	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.5	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.0	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0	0.3	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.7	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	1.0	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.5	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.1	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0	0.3	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.0	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.0	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.3	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.3	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.2	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.2	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.8	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.1	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.1	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.0	0.0	REACTOME SIGNALLING BY NGF	Genes involved in Signalling by NGF
0.0	0.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.2	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.0	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.0	0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.0	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.1	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.2	REACTOME PROLONGED ERK ACTIVATION EVENTS	Genes involved in Prolonged ERK activation events
0.0	0.0	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
0.0	0.1	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.1	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.0	0.1	REACTOME OPSINS	Genes involved in Opsins
0.0	0.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA