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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for HSF4

Z-value: 1.06

Motif logo

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Transcription factors associated with HSF4

Gene Symbol Gene ID Gene Info
HSF4
ENSG00000102878.11 heat shock transcription factor 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr16_67203074_67203225HSF41720.812528-0.674.7e-02Click!
chr16_67196662_67196813HSF45510.4459070.618.0e-02Click!
chr16_67198740_67198891HSF41000.9016920.581.0e-01Click!
chr16_67199421_67199612HSF4880.9083160.531.4e-01Click!
chr16_67197789_67198350HSF46460.4202900.383.1e-01Click!

Activity of the HSF4 motif across conditions

Conditions sorted by the z-value of the HSF4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr7_139312464_139312655 0.71 CLEC2L
 C-type lectin domain family 2, member L
 103731
 0.06
chr14_99670994_99671151 0.65 AL162151.4
46319
 0.15
chr7_1087128_1087349 0.65 GPR146
 G protein-coupled receptor 146
 3026
 0.13
chr21_36340846_36341061 0.62 RUNX1
 runt-related transcription factor 1
 78866
 0.12
chr5_156681732_156681896 0.62 CYFIP2
 cytoplasmic FMR1 interacting protein 2
 11277
 0.13
chr7_2739468_2739742 0.60 AMZ1
 archaelysin family metallopeptidase 1
 11769
 0.21
chr14_98657577_98657728 0.60 ENSG00000222066
 .
 140435
 0.05
chr22_27043526_27043866 0.57 CRYBA4
 crystallin, beta A4
 25768
 0.16
chr12_47758069_47758220 0.57 ENSG00000264906
 .
 92
 0.98
chr5_150597516_150598012 0.57 CCDC69
 coiled-coil domain containing 69
 5942
 0.19
chr8_37134401_37134693 0.55 RP11-150O12.6
239992
 0.02
chr16_3838912_3839326 0.54 CREBBP
 CREB binding protein
 8251
 0.23
chr1_100856884_100857083 0.54 ENSG00000216067
 .
 12652
 0.2
chr22_40327971_40328220 0.53 GRAP2
 GRB2-related adaptor protein 2
 5454
 0.19
chr10_14702537_14702914 0.51 ENSG00000201766
 .
 2768
 0.28
chr13_114914753_114915138 0.51 RASA3
 RAS p21 protein activator 3
 16859
 0.2
chr1_25350610_25350934 0.51 ENSG00000264371
 .
 778
 0.7
chr11_128598285_128598783 0.50 SENCR
 smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA
 32616
 0.15
chr16_67837738_67838160 0.49 RANBP10
 RAN binding protein 10
 2511
 0.15
chr1_118197732_118198071 0.49 ENSG00000212266
 .
 33463
 0.17
chr1_111437508_111437815 0.48 CD53
 CD53 molecule
 21885
 0.15
chr2_205833792_205833953 0.48 PARD3B
 par-3 family cell polarity regulator beta
 423149
 0.01
chr22_27071165_27071316 0.48 CRYBA4
 crystallin, beta A4
 53312
 0.12
chr8_27235111_27235488 0.47 PTK2B
 protein tyrosine kinase 2 beta
 2869
 0.31
chr13_114912317_114912766 0.47 RASA3
 RAS p21 protein activator 3
 14455
 0.21
chr1_24851023_24851224 0.46 ENSG00000266551
 .
 5081
 0.18
chrX_154417614_154417799 0.46 VBP1
 von Hippel-Lindau binding protein 1
 7578
 0.2
chr3_15332186_15332608 0.46 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
 14845
 0.14
chrX_64947728_64947879 0.46 MSN
 moesin
 60266
 0.16
chr19_4084516_4084732 0.46 MAP2K2
 mitogen-activated protein kinase kinase 2
 16421
 0.11
chr19_3757648_3757799 0.45 AC005954.3
1066
 0.31
chr16_68105212_68105363 0.45 NFATC3
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
 13960
 0.09
chr17_63025333_63025500 0.45 RP11-583F2.5
22611
 0.15
chr7_50422851_50423205 0.45 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 55783
 0.14
chr1_203255177_203255328 0.45 BTG2
 BTG family, member 2
 19412
 0.16
chr2_62430640_62430961 0.45 ENSG00000266097
 .
 2161
 0.29
chr9_82248211_82248468 0.45 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
 19169
 0.31
chr8_28917519_28917756 0.44 CTD-2647L4.4
4185
 0.17
chr4_154449092_154449243 0.44 KIAA0922
 KIAA0922
 27881
 0.22
chr12_122228197_122228738 0.44 RHOF
 ras homolog family member F (in filopodia)
 2799
 0.22
chr15_81576710_81577129 0.44 IL16
 interleukin 16
 12335
 0.21
chr5_169702138_169702842 0.44 LCP2
 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
 8159
 0.23
chr1_185250977_185251218 0.44 ENSG00000252612
 .
 15430
 0.16
chr14_69280428_69280742 0.43 ZFP36L1
 ZFP36 ring finger protein-like 1
 17395
 0.19
chr21_47972699_47973025 0.43 ENSG00000272283
 .
 17153
 0.17
chr17_63022687_63022838 0.43 RP11-583F2.5
25265
 0.14
chr8_22496270_22496646 0.43 BIN3
 bridging integrator 3
 5859
 0.12
chr19_42399773_42399960 0.43 ARHGEF1
 Rho guanine nucleotide exchange factor (GEF) 1
 414
 0.76
chr19_3756961_3757129 0.43 AC005954.3
388
 0.71
chr19_3813101_3813594 0.43 MATK
 megakaryocyte-associated tyrosine kinase
 11220
 0.11
chr2_3225421_3225572 0.43 TSSC1-IT1
 TSSC1 intronic transcript 1 (non-protein coding)
 79740
 0.1
chr21_45575872_45576023 0.43 AP001055.1
17633
 0.13
chr14_53211245_53211397 0.43 STYX
 serine/threonine/tyrosine interacting protein
 14421
 0.14
chr3_48551527_48551686 0.42 SHISA5
 shisa family member 5
 9347
 0.1
chr1_117544919_117545104 0.42 CD101
 CD101 molecule
 577
 0.73
chr1_154376165_154376624 0.42 IL6R
 interleukin 6 receptor
 1275
 0.33
chr8_59930806_59931005 0.42 RP11-328K2.1
25408
 0.23
chr11_6762047_6762301 0.42 GVINP1
 GTPase, very large interferon inducible pseudogene 1
 19063
 0.11
chr16_79320751_79320982 0.42 ENSG00000222244
 .
 22515
 0.27
chr2_135005025_135005319 0.42 MGAT5
 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
 6658
 0.26
chr19_41850700_41850906 0.41 TGFB1
 transforming growth factor, beta 1
 2868
 0.13
chr2_182177306_182177486 0.41 ENSG00000266705
 .
 7017
 0.32
chr1_25421803_25422058 0.41 ENSG00000264371
 .
 71936
 0.09
chr10_7201395_7201546 0.40 SFMBT2
 Scm-like with four mbt domains 2
 249237
 0.02
chr22_20819732_20820026 0.40 ENSG00000255156
 .
 9719
 0.1
chr17_55681912_55682272 0.39 RP11-118E18.4
3681
 0.24
chr10_26753045_26753285 0.39 APBB1IP
 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
 25811
 0.22
chr6_45462657_45462916 0.38 RUNX2
 runt-related transcription factor 2
 72564
 0.11
chr5_39155242_39155486 0.38 FYB
 FYN binding protein
 47765
 0.15
chr1_115009857_115010035 0.38 TRIM33
 tripartite motif containing 33
 3898
 0.27
chr20_50019481_50019826 0.38 ENSG00000263645
 .
 25795
 0.22
chr19_16379790_16380087 0.38 CTD-2562J15.6
24448
 0.13
chr9_132794767_132794918 0.38 FNBP1
 formin binding protein 1
 10599
 0.2
chr3_3213200_3213369 0.38 CRBN
 cereblon
 8074
 0.19
chr5_151175034_151175185 0.38 ATOX1
 antioxidant 1 copper chaperone
 23016
 0.15
chr16_85337462_85337809 0.38 ENSG00000266307
 .
 2296
 0.37
chr6_159139178_159139369 0.37 ENSG00000265558
 .
 46512
 0.12
chrX_6978429_6978580 0.37 ENSG00000264268
 .
 87397
 0.09
chr1_38138940_38139091 0.37 C1orf109
 chromosome 1 open reading frame 109
 17161
 0.12
chr22_40729451_40729738 0.37 ADSL
 adenylosuccinate lyase
 12913
 0.18
chr6_52150845_52151081 0.37 MCM3
 minichromosome maintenance complex component 3
 1328
 0.48
chr2_204865819_204865980 0.37 ICOS
 inducible T-cell co-stimulator
 64396
 0.14
chr3_12991701_12991859 0.37 IQSEC1
 IQ motif and Sec7 domain 1
 17388
 0.22
chr7_50321524_50321798 0.36 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 22663
 0.25
chr3_105552050_105552274 0.36 CBLB
 Cbl proto-oncogene B, E3 ubiquitin protein ligase
 35725
 0.25
chr5_158838800_158839019 0.36 IL12B
 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
 81014
 0.09
chr3_15319262_15319413 0.36 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
 1785
 0.29
chr2_109225906_109226290 0.36 LIMS1
 LIM and senescent cell antigen-like domains 1
 2481
 0.35
chr11_121452316_121452687 0.36 SORL1
 sortilin-related receptor, L(DLR class) A repeats containing
 4954
 0.34
chr12_6542028_6542189 0.36 CD27
 CD27 molecule
 11925
 0.09
chr19_9972790_9973038 0.35 OLFM2
 olfactomedin 2
 4070
 0.12
chr17_5292178_5292426 0.35 RABEP1
 rabaptin, RAB GTPase binding effector protein 1
 11796
 0.12
chr16_68453137_68453288 0.35 SMPD3
 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
 29183
 0.12
chr20_31555391_31555580 0.35 EFCAB8
 EF-hand calcium binding domain 8
 7834
 0.17
chr7_21393437_21393588 0.35 ENSG00000195024
 .
 27469
 0.2
chrX_129222828_129223069 0.35 ELF4
 E74-like factor 4 (ets domain transcription factor)
 21388
 0.19
chr1_65528171_65528405 0.35 ENSG00000199135
 .
 4097
 0.22
chr1_24235021_24235316 0.35 RP11-4M23.3
1567
 0.24
chr11_117821389_117821783 0.35 TMPRSS13
 transmembrane protease, serine 13
 21412
 0.15
chr4_40251320_40251540 0.35 RHOH
 ras homolog family member H
 49466
 0.13
chr15_81593592_81593958 0.35 IL16
 interleukin 16
 2018
 0.33
chr6_39195665_39195856 0.35 KCNK5
 potassium channel, subfamily K, member 5
 1466
 0.51
chr6_134953210_134953361 0.35 ALDH8A1
 aldehyde dehydrogenase 8 family, member A1
 297014
 0.01
chr1_183447249_183447596 0.34 SMG7
 SMG7 nonsense mediated mRNA decay factor
 5355
 0.23
chr1_169672251_169672700 0.34 SELL
 selectin L
 8364
 0.2
chr17_75959968_75960181 0.34 TNRC6C
 trinucleotide repeat containing 6C
 40175
 0.14
chr5_35788787_35788938 0.34 SPEF2
 sperm flagellar 2
 9592
 0.22
chr5_55351651_55351834 0.34 ENSG00000238326
 .
 55293
 0.09
chr1_26696466_26696677 0.34 ZNF683
 zinc finger protein 683
 665
 0.58
chr12_104880310_104880679 0.33 CHST11
 carbohydrate (chondroitin 4) sulfotransferase 11
 29715
 0.22
chr19_10254387_10254800 0.33 EIF3G
 eukaryotic translation initiation factor 3, subunit G
 24015
 0.07
chr4_8349309_8349460 0.33 ENSG00000202054
 .
 45358
 0.14
chr17_75395164_75395315 0.33 SEPT9
 septin 9
 1401
 0.34
chr9_78642998_78643161 0.33 PCSK5
 proprotein convertase subtilisin/kexin type 5
 67814
 0.13
chr16_85768216_85768412 0.33 ENSG00000222190
 .
 6992
 0.12
chr18_60911782_60912122 0.33 ENSG00000238988
 .
 50054
 0.12
chr13_114991565_114991854 0.33 CDC16
 cell division cycle 16
 8653
 0.18
chr12_121848379_121848530 0.33 RNF34
 ring finger protein 34, E3 ubiquitin protein ligase
 1176
 0.51
chr15_26056534_26056770 0.33 ENSG00000199214
 .
 6478
 0.21
chr9_112906499_112906706 0.32 AKAP2
 A kinase (PRKA) anchor protein 2
 18821
 0.24
chr9_112713247_112713398 0.32 PALM2
 paralemmin 2
 84011
 0.09
chr6_139452567_139452918 0.32 HECA
 headcase homolog (Drosophila)
 3507
 0.32
chr10_51517238_51517411 0.32 AGAP7
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 7
 30997
 0.14
chrX_41775628_41775779 0.32 ENSG00000251807
 .
 2899
 0.31
chr5_130597752_130597932 0.32 CDC42SE2
 CDC42 small effector 2
 1860
 0.47
chr10_27087573_27087735 0.32 ENSG00000206605
 .
 8079
 0.19
chr2_48078802_48078953 0.32 FBXO11
 F-box protein 11
 15776
 0.21
chr1_226916534_226916814 0.32 ITPKB
 inositol-trisphosphate 3-kinase B
 8485
 0.23
chr10_11213546_11213708 0.32 RP3-323N1.2
288
 0.92
chr17_7456942_7457093 0.32 TNFSF12
 tumor necrosis factor (ligand) superfamily, member 12
 4546
 0.06
chr13_77793771_77793922 0.32 MYCBP2
 MYC binding protein 2, E3 ubiquitin protein ligase
 106968
 0.07
chr6_24955515_24955958 0.32 FAM65B
 family with sequence similarity 65, member B
 19548
 0.21
chr5_72528452_72528679 0.32 TMEM174
 transmembrane protein 174
 59543
 0.12
chrX_135709367_135709640 0.32 ENSG00000233093
 .
 12199
 0.16
chr2_158750571_158750722 0.32 UPP2
 uridine phosphorylase 2
 17432
 0.16
chr19_5077571_5077794 0.32 KDM4B
 lysine (K)-specific demethylase 4B
 4781
 0.27
chr3_32498174_32498359 0.31 CMTM6
 CKLF-like MARVEL transmembrane domain containing 6
 46634
 0.14
chr20_58639264_58639415 0.31 C20orf197
 chromosome 20 open reading frame 197
 8359
 0.26
chr15_32651213_32651761 0.31 ENSG00000221444
 .
 34186
 0.1
chr11_121332248_121332530 0.31 RP11-730K11.1
8667
 0.24
chr15_59836576_59836759 0.31 ENSG00000201704
 .
 29754
 0.14
chr22_27040755_27040920 0.31 CRYBA4
 crystallin, beta A4
 22909
 0.17
chr1_226901230_226901381 0.31 ITPKB
 inositol-trisphosphate 3-kinase B
 23854
 0.18
chr14_64963769_64963936 0.31 ZBTB1
 zinc finger and BTB domain containing 1
 6591
 0.12
chr22_45068838_45068989 0.31 PRR5
 proline rich 5 (renal)
 4024
 0.25
chr2_197015707_197015858 0.30 RP11-347P5.1
205
 0.94
chr2_231521971_231522122 0.30 CAB39
 calcium binding protein 39
 55514
 0.11
chr11_114086673_114087539 0.30 NNMT
 nicotinamide N-methyltransferase
 41447
 0.17
chr1_231748922_231749511 0.30 LINC00582
 long intergenic non-protein coding RNA 582
 1380
 0.44
chr1_206556159_206556344 0.30 SRGAP2
 SLIT-ROBO Rho GTPase activating protein 2
 1115
 0.4
chr2_12642786_12642950 0.30 ENSG00000207183
 .
 91241
 0.1
chr6_88453159_88453310 0.30 ENSG00000238628
 .
 22601
 0.18
chr17_47813077_47813254 0.30 FAM117A
 family with sequence similarity 117, member A
 11276
 0.14
chr16_84628580_84628866 0.30 RP11-61F12.1
724
 0.65
chr7_101385381_101385615 0.30 CUX1
 cut-like homeobox 1
 73461
 0.1
chrX_135851684_135852073 0.30 ARHGEF6
 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
 1092
 0.49
chr2_235335702_235336092 0.30 ARL4C
 ADP-ribosylation factor-like 4C
 69347
 0.14
chr15_30471500_30471800 0.30 ENSG00000221785
 .
 34570
 0.11
chr1_42123736_42123959 0.29 HIVEP3
 human immunodeficiency virus type I enhancer binding protein 3
 42825
 0.18
chr3_15709764_15709915 0.29 ENSG00000264354
 .
 29039
 0.15
chr2_233179198_233179349 0.29 DIS3L2
 DIS3 mitotic control homolog (S. cerevisiae)-like 2
 19380
 0.17
chr13_28030262_28030413 0.29 MTIF3
 mitochondrial translational initiation factor 3
 5598
 0.19
chr6_28473877_28474028 0.29 GPX6
 glutathione peroxidase 6 (olfactory)
 9612
 0.17
chr10_115441935_115442086 0.29 CASP7
 caspase 7, apoptosis-related cysteine peptidase
 2311
 0.29
chr1_26865494_26865771 0.29 RPS6KA1
 ribosomal protein S6 kinase, 90kDa, polypeptide 1
 3971
 0.17
chr11_95375181_95375332 0.29 FAM76B
 family with sequence similarity 76, member B
 144713
 0.04
chr5_527247_527623 0.29 RP11-310P5.2
2615
 0.18
chr19_50835735_50835918 0.29 KCNC3
 potassium voltage-gated channel, Shaw-related subfamily, member 3
 946
 0.37
chr2_28572176_28572390 0.29 AC093690.1
38957
 0.13
chr10_14698882_14699236 0.29 RP11-7C6.1
4318
 0.23
chr1_779209_779379 0.29 RP11-206L10.8
33753
 0.1
chr18_72075391_72075542 0.29 FAM69C
 family with sequence similarity 69, member C
 49037
 0.14
chr10_11252452_11252842 0.29 RP3-323N1.2
39308
 0.17
chr17_56456497_56456648 0.29 RNF43
 ring finger protein 43
 23510
 0.11
chr2_13037487_13037811 0.29 ENSG00000264370
 .
 160156
 0.04
chr3_107673374_107673767 0.29 CD47
 CD47 molecule
 103638
 0.08
chr19_4641704_4641855 0.29 TNFAIP8L1
 tumor necrosis factor, alpha-induced protein 8-like 1
 1750
 0.24
chr10_13160669_13160820 0.29 OPTN
 optineurin
 2476
 0.29
chr2_241564217_241564368 0.29 GPR35
 G protein-coupled receptor 35
 370
 0.81
chr5_156644620_156644840 0.29 CTB-4E7.1
6660
 0.14
chr8_28936608_28936759 0.29 CTD-2647L4.5
11887
 0.14
chr3_3233085_3233387 0.29 CRBN
 cereblon
 11842
 0.2
chr9_92044873_92045111 0.29 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 6386
 0.26
chr16_4725775_4726545 0.29 NUDT16L1
 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1
 17535
 0.1
chr19_42276662_42276849 0.29 AC011513.4
14046
 0.12
chr7_157263857_157264008 0.29 AC006372.6
42056
 0.16
chr3_18540522_18540673 0.29 ENSG00000228956
 .
 27291
 0.22
chr2_85101975_85102126 0.29 TRABD2A
 TraB domain containing 2A
 6156
 0.2
chr4_144441518_144441669 0.28 SMARCA5-AS1
 SMARCA5 antisense RNA 1
 5805
 0.23
chr20_44832267_44832487 0.28 CDH22
 cadherin 22, type 2
 47957
 0.13
chr14_99645282_99645517 0.28 AL162151.4
20646
 0.24
chr1_160612345_160612670 0.28 SLAMF1
 signaling lymphocytic activation molecule family member 1
 4304
 0.19
chr3_42388906_42389324 0.28 LYZL4
 lysozyme-like 4
 62935
 0.1
chr1_25436980_25437131 0.28 ENSG00000264371
 .
 87061
 0.07
chr12_133289810_133290003 0.28 PGAM5
 phosphoglycerate mutase family member 5
 1433
 0.3
chr19_5952060_5952229 0.28 RANBP3
 RAN binding protein 3
 25946
 0.08
chr5_118648731_118648896 0.28 ENSG00000243333
 .
 6487
 0.21
chr14_25140513_25140664 0.28 GZMB
 granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
 37115
 0.14
chr14_104858355_104858716 0.28 ENSG00000222761
 .
 8850
 0.27
chr5_39160522_39160673 0.28 FYB
 FYN binding protein
 42532
 0.17

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.1 0.2 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.1 0.6 GO:0007172 signal complex assembly(GO:0007172)
0.1 0.2 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 0.2 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1 0.2 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1 0.1 GO:0002890 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.1 0.3 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.3 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1 0.2 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.1 0.2 GO:0030952 establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.1 0.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.1 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0 0.3 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.1 GO:0002870 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.5 GO:0045061 thymic T cell selection(GO:0045061)
0.0 0.2 GO:0050685 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.0 GO:2000041 regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0 0.2 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.0 0.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.2 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:2000380 regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0 0.1 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.1 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0048087 positive regulation of developmental pigmentation(GO:0048087)
0.0 0.1 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.3 GO:0019059 obsolete initiation of viral infection(GO:0019059)
0.0 0.1 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.3 GO:0002418 immune response to tumor cell(GO:0002418)
0.0 0.1 GO:0006925 inflammatory cell apoptotic process(GO:0006925)
0.0 0.0 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.0 0.9 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 0.1 GO:0032100 positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0 0.1 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.2 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.1 GO:1901534 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.0 GO:0019042 viral latency(GO:0019042)
0.0 0.3 GO:0006911 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 0.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.0 GO:0071354 cellular response to interleukin-6(GO:0071354)
0.0 0.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.0 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.0 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.2 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.0 GO:0046101 hypoxanthine biosynthetic process(GO:0046101)
0.0 0.1 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.1 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.0 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.2 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.2 GO:0050684 regulation of mRNA processing(GO:0050684) regulation of mRNA metabolic process(GO:1903311)
0.0 0.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.0 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.1 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 0.1 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.1 GO:0002360 T cell lineage commitment(GO:0002360)
0.0 0.0 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.0 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.0 0.1 GO:0033033 negative regulation of myeloid cell apoptotic process(GO:0033033)
0.0 0.0 GO:0003161 cardiac conduction system development(GO:0003161)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.0 GO:0060976 coronary vasculature development(GO:0060976)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.0 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.1 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 0.1 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.0 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.0 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.0 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 0.1 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498)
0.0 0.1 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.0 0.0 GO:0002691 regulation of cellular extravasation(GO:0002691)
0.0 0.1 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.0 GO:0001743 optic placode formation(GO:0001743)
0.0 0.1 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.0 GO:0030910 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.1 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0 0.0 GO:0010661 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.1 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:0045759 negative regulation of action potential(GO:0045759)
0.0 0.1 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.1 GO:0048563 post-embryonic organ morphogenesis(GO:0048563)
0.0 0.0 GO:0032817 regulation of natural killer cell proliferation(GO:0032817)
0.0 0.0 GO:0051788 response to misfolded protein(GO:0051788)
0.0 0.1 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.0 0.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.1 GO:1902222 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0 0.0 GO:1904376 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.0 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0 0.0 GO:0060789 hair follicle placode formation(GO:0060789)
0.0 0.0 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.0 GO:0032212 positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0 0.0 GO:0061054 dermatome development(GO:0061054)
0.0 0.0 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.2 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0 0.1 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.0 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.0 GO:0048143 astrocyte activation(GO:0048143)
0.0 0.0 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.0 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.0 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.0 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0 0.0 GO:0006922 obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0 0.0 GO:0001973 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.0 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:0043049 otic placode formation(GO:0043049)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546)
0.0 0.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0043558 regulation of translational initiation in response to stress(GO:0043558)
0.0 0.0 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.2 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.0 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.0 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0035246 peptidyl-arginine N-methylation(GO:0035246)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.0 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.2 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.1 GO:0046618 drug export(GO:0046618)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0060287 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0006734 NADH metabolic process(GO:0006734)
0.0 0.1 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0 0.1 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.0 GO:0090192 regulation of glomerulus development(GO:0090192)
0.0 0.1 GO:0036230 granulocyte activation(GO:0036230)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.0 GO:0032898 neurotrophin production(GO:0032898)
0.0 0.0 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.0 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.0 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.1 GO:0043628 ncRNA 3'-end processing(GO:0043628)
0.0 0.0 GO:0031297 replication fork processing(GO:0031297)
0.0 0.0 GO:1901984 negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0 0.0 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.1 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.0 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.0 0.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.0 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.0 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533) regulation of activation of JAK2 kinase activity(GO:0010534) positive regulation of activation of JAK2 kinase activity(GO:0010535) positive regulation of activation of Janus kinase activity(GO:0010536)
0.0 0.0 GO:0043368 positive T cell selection(GO:0043368)
0.0 0.0 GO:1902803 regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 0.1 GO:0060438 trachea development(GO:0060438)
0.0 0.0 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 0.0 GO:0045634 regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0 0.0 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.0 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.1 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.0 0.1 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.1 GO:0042435 indole-containing compound biosynthetic process(GO:0042435)
0.0 0.2 GO:0043526 obsolete neuroprotection(GO:0043526)
0.0 0.0 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.2 GO:0097581 lamellipodium organization(GO:0097581)
0.0 0.0 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.0 GO:0017085 response to insecticide(GO:0017085)
0.0 0.1 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.0 0.1 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 0.1 GO:0036465 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.0 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.0 GO:0060677 ureteric bud elongation(GO:0060677)
0.0 0.0 GO:0042253 granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253) regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0 0.0 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.2 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 0.0 GO:0043374 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.0 GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.3 GO:0043218 compact myelin(GO:0043218)
0.1 0.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0031904 endosome lumen(GO:0031904)
0.0 0.1 GO:0070938 contractile ring(GO:0070938)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.1 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0000791 euchromatin(GO:0000791)
0.0 0.1 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.6 GO:0009295 nucleoid(GO:0009295)
0.0 0.0 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.0 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0033011 perinuclear theca(GO:0033011)
0.0 0.0 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.1 GO:0043209 myelin sheath(GO:0043209)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.5 GO:0030175 filopodium(GO:0030175)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.2 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.1 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.1 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.0 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.0 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.0 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.0 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0 0.1 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.1 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.0 GO:0099738 cell cortex region(GO:0099738)
0.0 0.1 GO:0031010 ISWI-type complex(GO:0031010)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 0.2 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 0.2 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.1 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.2 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.2 GO:0050542 icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.1 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.2 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.2 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.4 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.2 GO:0051766 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.1 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.0 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.0 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.0 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0016715 dopamine beta-monooxygenase activity(GO:0004500) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.1 GO:0004075 biotin carboxylase activity(GO:0004075)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.1 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.0 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0030276 clathrin binding(GO:0030276)
0.0 0.4 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.0 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.0 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.0 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0051400 BH domain binding(GO:0051400)
0.0 0.4 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.0 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.0 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.1 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.0 GO:0034187 obsolete apolipoprotein E binding(GO:0034187)
0.0 0.0 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451)
0.0 0.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.0 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.1 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.1 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.0 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.0 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.0 GO:0046980 tapasin binding(GO:0046980)
0.0 0.0 GO:0004802 transketolase activity(GO:0004802)
0.0 0.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.0 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.1 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.0 0.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.0 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.2 GO:0043022 ribosome binding(GO:0043022)
0.0 0.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.0 0.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0031996 thioesterase binding(GO:0031996)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.2 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 1.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.7 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.6 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.7 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.2 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 0.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.2 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.0 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.3 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.3 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.3 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.4 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.1 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.0 PID S1P S1P2 PATHWAY S1P2 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.6 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.5 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.0 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 0.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.7 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.0 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.1 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.3 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.0 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.0 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.3 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.3 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.8 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.1 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.1 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.0 REACTOME SIGNALLING BY NGF Genes involved in Signalling by NGF
0.0 0.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 0.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.0 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.0 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.1 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.2 REACTOME PROLONGED ERK ACTIVATION EVENTS Genes involved in Prolonged ERK activation events
0.0 0.0 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.0 0.1 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.1 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 0.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.1 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA