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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for IRF3

Z-value: 1.31

Motif logo

Transcription factors associated with IRF3

Gene Symbol	Gene ID	Gene Info
IRF3 Ensembl NCBI GeneCards UniProt	ENSG00000126456.11	IRF3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
IRF3	chr19_50168266_50168469	59	0.836579	0.64	6.1e-02	Click!
IRF3	chr19_50168006_50168157	14	0.899155	0.53	1.4e-01	Click!
IRF3	chr19_50167443_50167632	558	0.457522	0.50	1.7e-01	Click!
IRF3	chr19_50162147_50162298	5873	0.071742	-0.30	4.4e-01	Click!
IRF3	chr19_50166639_50166988	1282	0.192093	0.27	4.9e-01	Click!

Activity of the IRF3 motif across conditions

Conditions sorted by the z-value of the IRF3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_198480069_198480220	0.71	RFTN2	raftlin family member 2	2475	0.31
chr11_33182270_33182533	0.48	CSTF3	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa	605	0.51
chr19_47217852_47218003	0.45	PRKD2	protein kinase D2	71	0.94
chr6_152270159_152270310	0.40	ESR1	estrogen receptor 1	68442	0.13
chr10_126223396_126223623	0.40	LHPP	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	73097	0.09
chr22_34249799_34250025	0.39	LARGE	like-glycosyltransferase	7700	0.27
chr9_20623530_20623717	0.39	MLLT3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	1081	0.55
chr1_47060166_47060317	0.39	MKNK1	MAP kinase interacting serine/threonine kinase 1	289	0.88
chr22_19417405_19417667	0.39	HIRA	histone cell cycle regulator	1683	0.2
chr16_19083888_19084039	0.39	COQ7	coenzyme Q7 homolog, ubiquinone (yeast)	4652	0.17
chr10_43429375_43429752	0.38	ENSG00000263795	.	63448	0.12
chr5_176938568_176938719	0.36	DOK3	docking protein 3	368	0.75
chr2_27108887_27109038	0.35	DPYSL5	dihydropyrimidinase-like 5	37586	0.13
chr20_58712679_58712887	0.34	C20orf197	chromosome 20 open reading frame 197	81803	0.1
chr12_89551166_89551590	0.34	ENSG00000238302	.	124684	0.06
chr18_9700449_9700600	0.34	RAB31	RAB31, member RAS oncogene family	7638	0.23
chr13_29041064_29041377	0.34	FLT1	fms-related tyrosine kinase 1	28012	0.24
chr16_23540221_23540372	0.33	GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	6980	0.14
chr7_8007598_8007760	0.32	GLCCI1	glucocorticoid induced transcript 1	746	0.59
chr10_13142624_13142986	0.32	OPTN	optineurin	580	0.64
chr11_33895099_33895282	0.32	LMO2	LIM domain only 2 (rhombotin-like 1)	3828	0.24
chr8_104090645_104090882	0.32	ENSG00000265667	.	14186	0.14
chr4_5035629_5036207	0.32	CYTL1	cytokine-like 1	14719	0.22
chr1_17636167_17636318	0.31	PADI4	peptidyl arginine deiminase, type IV	1550	0.36
chr7_25898359_25898510	0.31	ENSG00000199085	.	91172	0.09
chr6_139693993_139694144	0.31	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	1282	0.57
chr6_20207196_20207347	0.31	RP11-239H6.2		5047	0.25
chr13_29106267_29106418	0.31	FLT1	fms-related tyrosine kinase 1	37077	0.21
chr10_82358758_82358909	0.31	SH2D4B	SH2 domain containing 4B	58258	0.13
chr12_113415972_113416272	0.30	OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	78	0.97
chr5_137801729_137801883	0.30	EGR1	early growth response 1	627	0.69
chr1_247336437_247336716	0.30	ZNF124	zinc finger protein 124	1258	0.39
chr12_7053100_7053251	0.30	C12orf57	chromosome 12 open reading frame 57	11	0.66
chr17_33570615_33570828	0.30	SLFN5	schlafen family member 5	613	0.47
chr14_90033233_90033446	0.29	FOXN3-AS2	FOXN3 antisense RNA 2	9221	0.17
chr8_126497882_126498033	0.29	ENSG00000266452	.	41150	0.18
chr2_136780779_136780951	0.29	AC093391.2		10830	0.23
chr17_8024292_8024443	0.29	ALOXE3	arachidonate lipoxygenase 3	2002	0.15
chr4_140426120_140426271	0.28	RP11-83A24.2		51007	0.1
chr20_39571883_39572034	0.28	ENSG00000222612	.	80887	0.09
chr22_17588430_17588590	0.28	CECR6	cat eye syndrome chromosome region, candidate 6	13633	0.14
chr18_3877337_3877666	0.28	DLGAP1-AS3	DLGAP1 antisense RNA 3	679	0.65
chr1_192829951_192830102	0.28	ENSG00000223075	.	15089	0.24
chr8_24206460_24207135	0.28	ADAM28	ADAM metallopeptidase domain 28	7632	0.22
chr11_111101268_111101555	0.28	C11orf53	chromosome 11 open reading frame 53	25296	0.18
chr3_7724702_7724983	0.28	RP11-157E16.1		75258	0.12
chr9_33320777_33320971	0.28	NFX1	nuclear transcription factor, X-box binding 1	30331	0.12
chr15_85873197_85873348	0.28	AKAP13	A kinase (PRKA) anchor protein 13	50546	0.11
chr16_88521210_88521549	0.28	ZFPM1	zinc finger protein, FOG family member 1	1654	0.34
chr6_154674292_154674443	0.27	IPCEF1	interaction protein for cytohesin exchange factors 1	3502	0.36
chr18_33070553_33070704	0.27	INO80C	INO80 complex subunit C	3194	0.27
chr20_52253425_52253583	0.27	ZNF217	zinc finger protein 217	28073	0.17
chr3_4711265_4711416	0.27	ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	153164	0.04
chr2_86244884_86245048	0.27	POLR1A	polymerase (RNA) I polypeptide A, 194kDa	88312	0.06
chr10_14996335_14996590	0.27	DCLRE1C	DNA cross-link repair 1C	31	0.98
chr5_166410441_166410592	0.27	TENM2	teneurin transmembrane protein 2	301288	0.01
chr14_76657346_76657538	0.27	GPATCH2L	G patch domain containing 2-like	4809	0.27
chr3_194033211_194033441	0.27	CPN2	carboxypeptidase N, polypeptide 2	38721	0.15
chr1_204452069_204452220	0.26	PIK3C2B	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	7302	0.19
chr12_127567917_127568068	0.26	ENSG00000239776	.	82680	0.12
chr3_69433628_69433794	0.26	FRMD4B	FERM domain containing 4B	1513	0.57
chr19_19439561_19440144	0.26	MAU2	MAU2 sister chromatid cohesion factor	8057	0.13
chr12_9964006_9964157	0.26	KLRF1	killer cell lectin-like receptor subfamily F, member 1	15996	0.14
chr2_27109662_27109955	0.26	DPYSL5	dihydropyrimidinase-like 5	38432	0.13
chr6_11581693_11581844	0.26	TMEM170B	transmembrane protein 170B	43257	0.17
chr1_203051666_203051922	0.26	MYOG	myogenin (myogenic factor 4)	3370	0.17
chr3_128916268_128916630	0.26	CNBP	CCHC-type zinc finger, nucleic acid binding protein	13684	0.14
chr3_100054819_100055039	0.26	NIT2	nitrilase family, member 2	1274	0.49
chr9_7533037_7533188	0.25	TMEM261	transmembrane protein 261	266955	0.02
chr3_187529226_187529377	0.25	BCL6	B-cell CLL/lymphoma 6	65786	0.12
chr10_35784890_35785041	0.25	GJD4	gap junction protein, delta 4, 40.1kDa	109373	0.06
chr19_49127703_49127921	0.25	SPHK2	sphingosine kinase 2	127	0.77
chr6_116833439_116833590	0.25	TRAPPC3L	trafficking protein particle complex 3-like	8	0.93
chr12_54765807_54765981	0.25	GPR84	G protein-coupled receptor 84	7623	0.09
chr19_54584658_54584809	0.25	TARM1	T cell-interacting, activating receptor on myeloid cells 1	99	0.93
chr5_100114059_100114278	0.25	ENSG00000221263	.	38101	0.19
chr10_5987513_5987753	0.25	RP11-536K7.3		68	0.97
chr8_109674261_109674444	0.25	TMEM74	transmembrane protein 74	125492	0.06
chr5_68463336_68463586	0.25	CCNB1	cyclin B1	371	0.77
chr12_26888585_26888736	0.25	ITPR2	inositol 1,4,5-trisphosphate receptor, type 2	97054	0.07
chr16_4850786_4851082	0.25	ROGDI	rogdi homolog (Drosophila)	355	0.77
chr9_77112278_77112453	0.25	RORB	RAR-related orphan receptor B	84	0.97
chr4_173707980_173708237	0.25	ENSG00000241652	.	354686	0.01
chr15_50404931_50405220	0.25	ATP8B4	ATPase, class I, type 8B, member 4	1626	0.45
chr5_150477986_150478137	0.25	TNIP1	TNFAIP3 interacting protein 1	4923	0.21
chr1_197170977_197171128	0.24	CRB1	crumbs homolog 1 (Drosophila)	460	0.77
chr6_14744067_14744218	0.24	ENSG00000206960	.	97376	0.09
chr12_116757651_116758051	0.24	MED13L	mediator complex subunit 13-like	42708	0.16
chr6_6857532_6857683	0.24	ENSG00000240936	.	81523	0.11
chr5_75992073_75992255	0.24	F2R	coagulation factor II (thrombin) receptor	19704	0.16
chr4_60684323_60684624	0.24	ENSG00000201676	.	14420	0.24
chr7_18184166_18184423	0.24	ENSG00000221393	.	17362	0.24
chr4_105979647_105979990	0.24	ENSG00000252136	.	47326	0.16
chr20_44509523_44509687	0.24	ZSWIM1	zinc finger, SWIM-type containing 1	261	0.8
chr1_180248686_180248990	0.24	RP5-1180C10.2		3479	0.3
chr3_29194998_29195333	0.24	RBMS3	RNA binding motif, single stranded interacting protein 3	127308	0.05
chr4_146540899_146541050	0.24	MMAA	methylmalonic aciduria (cobalamin deficiency) cblA type	1559	0.42
chr12_121019480_121019828	0.24	POP5	processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)	453	0.74
chr3_169720111_169720354	0.24	SEC62-AS1	SEC62 antisense RNA 1	16729	0.13
chr19_15054504_15054655	0.24	OR7C2	olfactory receptor, family 7, subfamily C, member 2	2278	0.26
chrX_15448302_15448453	0.24	BMX	BMX non-receptor tyrosine kinase	33992	0.15
chr1_45023108_45023259	0.24	ENSG00000263381	.	12018	0.2
chr2_145443692_145443848	0.24	ZEB2	zinc finger E-box binding homeobox 2	165149	0.04
chr10_125865907_125866246	0.24	CHST15	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	12870	0.28
chr1_181056660_181057120	0.23	IER5	immediate early response 5	748	0.71
chr2_148779503_148779985	0.23	ORC4	origin recognition complex, subunit 4	597	0.65
chr2_118856015_118856215	0.23	INSIG2	insulin induced gene 2	10065	0.24
chr3_128313216_128313433	0.23	C3orf27	chromosome 3 open reading frame 27	18395	0.19
chr15_69075380_69075658	0.23	ENSG00000265195	.	18745	0.22
chr10_45874886_45875037	0.23	ALOX5	arachidonate 5-lipoxygenase	5286	0.27
chr6_21589300_21589525	0.23	SOX4	SRY (sex determining region Y)-box 4	4560	0.37
chr8_102923998_102924149	0.23	NCALD	neurocalcin delta	63484	0.13
chrX_13754467_13754844	0.23	OFD1	oral-facial-digital syndrome 1	1791	0.29
chr7_100011522_100011687	0.23	ZCWPW1	zinc finger, CW type with PWWP domain 1	4436	0.09
chr22_36556784_36556935	0.23	APOL3	apolipoprotein L, 3	28	0.98
chr1_46052215_46052366	0.23	NASP	nuclear autoantigenic sperm protein (histone-binding)	2553	0.23
chr2_176495143_176495353	0.23	AC016751.3		266816	0.01
chr17_79360953_79361175	0.23	RP11-1055B8.6	Uncharacterized protein	8211	0.12
chr13_105829604_105829896	0.23	DAOA	D-amino acid oxidase activator	288842	0.01
chr16_28518181_28518332	0.23	IL27	interleukin 27	101	0.95
chr9_33759387_33759538	0.23	PRSS3	protease, serine, 3	8643	0.14
chr19_14877311_14877462	0.23	EMR2	egf-like module containing, mucin-like, hormone receptor-like 2	5800	0.16
chr11_66115431_66115582	0.23	RP11-867G23.8	Uncharacterized protein	85	0.76
chr4_85888329_85888497	0.23	WDFY3	WD repeat and FYVE domain containing 3	869	0.72
chr12_57773877_57774028	0.23	ENSG00000201198	.	35127	0.09
chr1_85411015_85411201	0.23	MCOLN2	mucolipin 2	51515	0.12
chr17_1992881_1993032	0.23	RP11-667K14.5		19	0.96
chr17_59940538_59940689	0.22	BRIP1	BRCA1 interacting protein C-terminal helicase 1	92	0.97
chr4_4292418_4292569	0.22	ZBTB49	zinc finger and BTB domain containing 49	497	0.52
chr17_58754505_58754656	0.22	BCAS3	breast carcinoma amplified sequence 3	234	0.92
chrX_13770949_13771164	0.22	OFD1	oral-facial-digital syndrome 1	18192	0.17
chrX_16846441_16846592	0.22	RBBP7	retinoblastoma binding protein 7	23672	0.15
chr17_30214979_30215206	0.22	UTP6	UTP6, small subunit (SSU) processome component, homolog (yeast)	13692	0.18
chr9_33221071_33221222	0.22	SPINK4	serine peptidase inhibitor, Kazal type 4	169	0.94
chr11_108095836_108095987	0.22	ATM	ataxia telangiectasia mutated	1106	0.42
chr15_52733385_52733536	0.22	MYO5A	myosin VA (heavy chain 12, myoxin)	5593	0.28
chr12_53937677_53937943	0.22	RP11-793H13.3		30042	0.1
chr11_128554939_128555157	0.22	RP11-744N12.3		1275	0.35
chr1_20959712_20959863	0.22	PINK1	PTEN induced putative kinase 1	161	0.95
chr6_611011_611162	0.22	HUS1B	HUS1 checkpoint homolog b (S. pombe)	45877	0.17
chr1_228328808_228329114	0.22	GUK1	guanylate kinase 1	122	0.93
chr6_5999961_6000211	0.22	NRN1	neuritin 1	7114	0.26
chr1_89150817_89151520	0.22	RP11-76N22.2		281	0.84
chr6_35697474_35697939	0.22	FKBP5	FK506 binding protein 5	1346	0.31
chr11_47972062_47972213	0.22	PTPRJ	protein tyrosine phosphatase, receptor type, J	29976	0.17
chr6_106546899_106547210	0.21	PRDM1	PR domain containing 1, with ZNF domain	239	0.88
chr5_137679824_137679975	0.21	RP11-256P1.1		5431	0.13
chr18_20722941_20723198	0.21	ENSG00000222999	.	6593	0.21
chr4_169239823_169239974	0.21	DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	57	0.98
chr10_126430141_126430442	0.21	FAM53B	family with sequence similarity 53, member B	1248	0.43
chr22_19465272_19465744	0.21	UFD1L	ubiquitin fusion degradation 1 like (yeast)	946	0.35
chr18_74162951_74163102	0.21	ZNF516	zinc finger protein 516	39709	0.14
chr10_82215641_82216144	0.21	TSPAN14	tetraspanin 14	1781	0.38
chr9_127005358_127005801	0.21	NEK6	NIMA-related kinase 6	14306	0.17
chr3_135912382_135912568	0.21	MSL2	male-specific lethal 2 homolog (Drosophila)	921	0.68
chr4_125624499_125624650	0.21	ANKRD50	ankyrin repeat domain 50	9313	0.34
chr12_22830855_22831006	0.21	ETNK1	ethanolamine kinase 1	52639	0.15
chr3_176919574_176920023	0.21	TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	4537	0.31
chr1_26450910_26451453	0.21	PDIK1L	PDLIM1 interacting kinase 1 like	12841	0.11
chr19_54559994_54560145	0.21	VSTM1	V-set and transmembrane domain containing 1	1608	0.22
chr1_42195372_42195655	0.21	HIVEP3	human immunodeficiency virus type I enhancer binding protein 3	28841	0.2
chr1_151668701_151668852	0.21	RP11-98D18.1		4726	0.1
chr5_159698543_159698722	0.21	ENSG00000243654	.	20163	0.16
chr3_128583649_128583920	0.21	RP11-723O4.2		663	0.69
chr17_59222293_59222572	0.21	RP11-136H19.1		9107	0.23
chr16_48644531_48644682	0.20	N4BP1	NEDD4 binding protein 1	486	0.81
chr3_71731013_71731282	0.20	EIF4E3	eukaryotic translation initiation factor 4E family member 3	43379	0.15
chrX_109280296_109280497	0.20	ENSG00000208013	.	18161	0.2
chr9_92020971_92021287	0.20	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	288	0.93
chr7_116594399_116594611	0.20	ST7	suppression of tumorigenicity 7	60	0.54
chr11_128089678_128089829	0.20	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	285536	0.01
chrX_9547118_9547269	0.20	TBL1X	transducin (beta)-like 1X-linked	44210	0.2
chr15_50345522_50345833	0.20	ATP8B4	ATPase, class I, type 8B, member 4	6093	0.27
chr1_21292036_21292187	0.20	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	7418	0.23
chr2_145275679_145275945	0.20	ZEB2	zinc finger E-box binding homeobox 2	16	0.51
chr10_65388709_65389027	0.20	REEP3	receptor accessory protein 3	107745	0.07
chr9_132682421_132682638	0.20	FNBP1	formin binding protein 1	940	0.56
chr9_113096398_113096701	0.20	TXNDC8	thioredoxin domain containing 8 (spermatozoa)	3539	0.28
chr2_210852878_210853031	0.20	RPE	ribulose-5-phosphate-3-epimerase	14335	0.18
chr16_54210277_54210428	0.20	RP11-324D17.1	HCG2045435; Uncharacterized protein	70525	0.11
chr8_124170086_124170384	0.20	FAM83A	family with sequence similarity 83, member A	21052	0.11
chr22_25782542_25782779	0.20	LRP5L	low density lipoprotein receptor-related protein 5-like	5116	0.24
chr2_169957115_169957325	0.20	AC007556.3		33	0.98
chr7_150104070_150104221	0.20	RP4-584D14.6		23172	0.11
chr1_212809981_212810132	0.20	RP11-338C15.5		9943	0.14
chr9_35569725_35569931	0.20	FAM166B	family with sequence similarity 166, member B	5932	0.12
chr2_237973979_237974130	0.20	AC105760.3		9244	0.19
chr12_33047562_33047713	0.20	PKP2	plakophilin 2	2053	0.46
chr6_2838201_2838352	0.20	SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	3818	0.22
chr1_65522143_65522294	0.20	ENSG00000265996	.	1307	0.39
chr15_68502161_68502336	0.20	CALML4	calmodulin-like 4	3831	0.2
chr10_7449534_7449830	0.20	SFMBT2	Scm-like with four mbt domains 2	1025	0.67
chr14_106679120_106679271	0.19	IGHVII-20-1	immunoglobulin heavy variable (II)-20-1 (pseudogene)	9244	0.05
chr3_138954177_138954328	0.19	MRPS22	mitochondrial ribosomal protein S22	108609	0.06
chr8_128887727_128887885	0.19	TMEM75	transmembrane protein 75	72785	0.09
chr5_101622831_101622982	0.19	SLCO4C1	solute carrier organic anion transporter family, member 4C1	9347	0.21
chr2_55747454_55747845	0.19	CCDC104	coiled-coil domain containing 104	782	0.58
chr14_70172450_70172635	0.19	SRSF5	serine/arginine-rich splicing factor 5	21075	0.22
chr19_14186633_14186784	0.19	hsa-mir-1199	hsa-mir-1199	2314	0.15
chr7_48498957_48499108	0.19	ABCA13	ATP-binding cassette, sub-family A (ABC1), member 13	4372	0.37

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.2	GO:0072110	glomerular mesangial cell proliferation(GO:0072110) regulation of glomerular mesangial cell proliferation(GO:0072124)
0.1	0.2	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.1	0.2	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1	0.2	GO:0072600	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1	0.2	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.2	GO:0045625	regulation of T-helper 1 cell differentiation(GO:0045625)
0.0	0.2	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.2	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0070423	cytoplasmic pattern recognition receptor signaling pathway(GO:0002753) nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway(GO:0035872) nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.0	0.1	GO:2000143	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.2	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.1	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.2	GO:0002360	T cell lineage commitment(GO:0002360)
0.0	0.2	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0021860	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.3	GO:0006378	mRNA polyadenylation(GO:0006378)
0.0	0.4	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.0	0.1	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.1	GO:0034067	protein localization to Golgi apparatus(GO:0034067)
0.0	0.1	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.2	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.1	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.1	GO:1901798	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.2	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.1	GO:0048752	semicircular canal morphogenesis(GO:0048752)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:0032239	regulation of nucleobase-containing compound transport(GO:0032239)
0.0	0.1	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.1	GO:0035751	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.1	GO:0045885	obsolete positive regulation of survival gene product expression(GO:0045885)
0.0	0.1	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.1	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.0	GO:0060872	semicircular canal development(GO:0060872)
0.0	0.1	GO:0000132	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.1	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.0	0.0	GO:0071803	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.0	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.0	0.0	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.1	GO:0032727	positive regulation of interferon-alpha production(GO:0032727)
0.0	0.0	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0	0.1	GO:0071501	SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.0	GO:0006655	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0	0.1	GO:0045579	positive regulation of B cell differentiation(GO:0045579)
0.0	0.1	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.1	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.0	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.2	GO:0007379	segment specification(GO:0007379)
0.0	0.0	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.1	GO:0034405	response to fluid shear stress(GO:0034405)
0.0	0.0	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.1	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0	0.2	GO:0042255	ribosome assembly(GO:0042255)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.0	GO:1903429	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.0	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.2	GO:0001893	maternal placenta development(GO:0001893)
0.0	0.0	GO:0006991	response to sterol depletion(GO:0006991)
0.0	0.0	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.1	GO:0021903	rostrocaudal neural tube patterning(GO:0021903) midbrain-hindbrain boundary development(GO:0030917)
0.0	0.4	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.0	0.0	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0	0.1	GO:0006044	N-acetylglucosamine metabolic process(GO:0006044)
0.0	0.2	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	0.0	GO:0010980	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0	0.1	GO:0006824	cobalt ion transport(GO:0006824)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.1	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.0	0.0	GO:0006533	aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0	0.0	GO:0007000	nucleolus organization(GO:0007000)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.1	GO:0044462	external encapsulating structure part(GO:0044462)
0.0	0.2	GO:0030677	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.0	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.0	0.4	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.2	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.2	GO:0034518	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.0	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.5	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.0	GO:0070852	cell body fiber(GO:0070852)
0.0	0.3	GO:0005776	autophagosome(GO:0005776)
0.0	0.0	GO:0035098	ESC/E(Z) complex(GO:0035098)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0050693	LBD domain binding(GO:0050693)
0.1	0.2	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.1	0.3	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.3	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.3	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.4	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.2	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.2	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.1	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.3	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.2	GO:0035173	histone kinase activity(GO:0035173)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0035197	siRNA binding(GO:0035197)
0.0	0.2	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.2	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.0	0.2	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.1	GO:0022897	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.2	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.3	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.0	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.1	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.0	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.0	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.0	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.0	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0004305	ethanolamine kinase activity(GO:0004305)
0.0	0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.0	GO:0046980	tapasin binding(GO:0046980)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0070402	NADPH binding(GO:0070402)
0.0	0.0	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.5	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.0	0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.0	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.0	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.5	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.3	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.3	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.4	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.2	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.1	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.3	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.4	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.3	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.2	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.2	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.3	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.2	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.4	REACTOME G1 PHASE	Genes involved in G1 Phase
0.6	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.2	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling