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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for IRF3

Z-value: 1.31

Motif logo

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Transcription factors associated with IRF3

Gene Symbol Gene ID Gene Info
IRF3
ENSG00000126456.11 interferon regulatory factor 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr19_50168266_50168469IRF3590.8365790.646.1e-02Click!
chr19_50168006_50168157IRF3140.8991550.531.4e-01Click!
chr19_50167443_50167632IRF35580.4575220.501.7e-01Click!
chr19_50162147_50162298IRF358730.071742-0.304.4e-01Click!
chr19_50166639_50166988IRF312820.1920930.274.9e-01Click!

Activity of the IRF3 motif across conditions

Conditions sorted by the z-value of the IRF3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr2_198480069_198480220 0.71 RFTN2
 raftlin family member 2
 2475
 0.31
chr11_33182270_33182533 0.48 CSTF3
 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
 605
 0.51
chr19_47217852_47218003 0.45 PRKD2
 protein kinase D2
 71
 0.94
chr6_152270159_152270310 0.40 ESR1
 estrogen receptor 1
 68442
 0.13
chr10_126223396_126223623 0.40 LHPP
 phospholysine phosphohistidine inorganic pyrophosphate phosphatase
 73097
 0.09
chr22_34249799_34250025 0.39 LARGE
 like-glycosyltransferase
 7700
 0.27
chr9_20623530_20623717 0.39 MLLT3
 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
 1081
 0.55
chr1_47060166_47060317 0.39 MKNK1
 MAP kinase interacting serine/threonine kinase 1
 289
 0.88
chr22_19417405_19417667 0.39 HIRA
 histone cell cycle regulator
 1683
 0.2
chr16_19083888_19084039 0.39 COQ7
 coenzyme Q7 homolog, ubiquinone (yeast)
 4652
 0.17
chr10_43429375_43429752 0.38 ENSG00000263795
 .
 63448
 0.12
chr5_176938568_176938719 0.36 DOK3
 docking protein 3
 368
 0.75
chr2_27108887_27109038 0.35 DPYSL5
 dihydropyrimidinase-like 5
 37586
 0.13
chr20_58712679_58712887 0.34 C20orf197
 chromosome 20 open reading frame 197
 81803
 0.1
chr12_89551166_89551590 0.34 ENSG00000238302
 .
 124684
 0.06
chr18_9700449_9700600 0.34 RAB31
 RAB31, member RAS oncogene family
 7638
 0.23
chr13_29041064_29041377 0.34 FLT1
 fms-related tyrosine kinase 1
 28012
 0.24
chr16_23540221_23540372 0.33 GGA2
 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
 6980
 0.14
chr7_8007598_8007760 0.32 GLCCI1
 glucocorticoid induced transcript 1
 746
 0.59
chr10_13142624_13142986 0.32 OPTN
 optineurin
 580
 0.64
chr11_33895099_33895282 0.32 LMO2
 LIM domain only 2 (rhombotin-like 1)
 3828
 0.24
chr8_104090645_104090882 0.32 ENSG00000265667
 .
 14186
 0.14
chr4_5035629_5036207 0.32 CYTL1
 cytokine-like 1
 14719
 0.22
chr1_17636167_17636318 0.31 PADI4
 peptidyl arginine deiminase, type IV
 1550
 0.36
chr7_25898359_25898510 0.31 ENSG00000199085
 .
 91172
 0.09
chr6_139693993_139694144 0.31 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 1282
 0.57
chr6_20207196_20207347 0.31 RP11-239H6.2
5047
 0.25
chr13_29106267_29106418 0.31 FLT1
 fms-related tyrosine kinase 1
 37077
 0.21
chr10_82358758_82358909 0.31 SH2D4B
 SH2 domain containing 4B
 58258
 0.13
chr12_113415972_113416272 0.30 OAS2
 2'-5'-oligoadenylate synthetase 2, 69/71kDa
 78
 0.97
chr5_137801729_137801883 0.30 EGR1
 early growth response 1
 627
 0.69
chr1_247336437_247336716 0.30 ZNF124
 zinc finger protein 124
 1258
 0.39
chr12_7053100_7053251 0.30 C12orf57
 chromosome 12 open reading frame 57
 11
 0.66
chr17_33570615_33570828 0.30 SLFN5
 schlafen family member 5
 613
 0.47
chr14_90033233_90033446 0.29 FOXN3-AS2
 FOXN3 antisense RNA 2
 9221
 0.17
chr8_126497882_126498033 0.29 ENSG00000266452
 .
 41150
 0.18
chr2_136780779_136780951 0.29 AC093391.2
10830
 0.23
chr17_8024292_8024443 0.29 ALOXE3
 arachidonate lipoxygenase 3
 2002
 0.15
chr4_140426120_140426271 0.28 RP11-83A24.2
51007
 0.1
chr20_39571883_39572034 0.28 ENSG00000222612
 .
 80887
 0.09
chr22_17588430_17588590 0.28 CECR6
 cat eye syndrome chromosome region, candidate 6
 13633
 0.14
chr18_3877337_3877666 0.28 DLGAP1-AS3
 DLGAP1 antisense RNA 3
 679
 0.65
chr1_192829951_192830102 0.28 ENSG00000223075
 .
 15089
 0.24
chr8_24206460_24207135 0.28 ADAM28
 ADAM metallopeptidase domain 28
 7632
 0.22
chr11_111101268_111101555 0.28 C11orf53
 chromosome 11 open reading frame 53
 25296
 0.18
chr3_7724702_7724983 0.28 RP11-157E16.1
75258
 0.12
chr9_33320777_33320971 0.28 NFX1
 nuclear transcription factor, X-box binding 1
 30331
 0.12
chr15_85873197_85873348 0.28 AKAP13
 A kinase (PRKA) anchor protein 13
 50546
 0.11
chr16_88521210_88521549 0.28 ZFPM1
 zinc finger protein, FOG family member 1
 1654
 0.34
chr6_154674292_154674443 0.27 IPCEF1
 interaction protein for cytohesin exchange factors 1
 3502
 0.36
chr18_33070553_33070704 0.27 INO80C
 INO80 complex subunit C
 3194
 0.27
chr20_52253425_52253583 0.27 ZNF217
 zinc finger protein 217
 28073
 0.17
chr3_4711265_4711416 0.27 ITPR1
 inositol 1,4,5-trisphosphate receptor, type 1
 153164
 0.04
chr2_86244884_86245048 0.27 POLR1A
 polymerase (RNA) I polypeptide A, 194kDa
 88312
 0.06
chr10_14996335_14996590 0.27 DCLRE1C
 DNA cross-link repair 1C
 31
 0.98
chr5_166410441_166410592 0.27 TENM2
 teneurin transmembrane protein 2
 301288
 0.01
chr14_76657346_76657538 0.27 GPATCH2L
 G patch domain containing 2-like
 4809
 0.27
chr3_194033211_194033441 0.27 CPN2
 carboxypeptidase N, polypeptide 2
 38721
 0.15
chr1_204452069_204452220 0.26 PIK3C2B
 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
 7302
 0.19
chr12_127567917_127568068 0.26 ENSG00000239776
 .
 82680
 0.12
chr3_69433628_69433794 0.26 FRMD4B
 FERM domain containing 4B
 1513
 0.57
chr19_19439561_19440144 0.26 MAU2
 MAU2 sister chromatid cohesion factor
 8057
 0.13
chr12_9964006_9964157 0.26 KLRF1
 killer cell lectin-like receptor subfamily F, member 1
 15996
 0.14
chr2_27109662_27109955 0.26 DPYSL5
 dihydropyrimidinase-like 5
 38432
 0.13
chr6_11581693_11581844 0.26 TMEM170B
 transmembrane protein 170B
 43257
 0.17
chr1_203051666_203051922 0.26 MYOG
 myogenin (myogenic factor 4)
 3370
 0.17
chr3_128916268_128916630 0.26 CNBP
 CCHC-type zinc finger, nucleic acid binding protein
 13684
 0.14
chr3_100054819_100055039 0.26 NIT2
 nitrilase family, member 2
 1274
 0.49
chr9_7533037_7533188 0.25 TMEM261
 transmembrane protein 261
 266955
 0.02
chr3_187529226_187529377 0.25 BCL6
 B-cell CLL/lymphoma 6
 65786
 0.12
chr10_35784890_35785041 0.25 GJD4
 gap junction protein, delta 4, 40.1kDa
 109373
 0.06
chr19_49127703_49127921 0.25 SPHK2
 sphingosine kinase 2
 127
 0.77
chr6_116833439_116833590 0.25 TRAPPC3L
 trafficking protein particle complex 3-like
 8
 0.93
chr12_54765807_54765981 0.25 GPR84
 G protein-coupled receptor 84
 7623
 0.09
chr19_54584658_54584809 0.25 TARM1
 T cell-interacting, activating receptor on myeloid cells 1
 99
 0.93
chr5_100114059_100114278 0.25 ENSG00000221263
 .
 38101
 0.19
chr10_5987513_5987753 0.25 RP11-536K7.3
68
 0.97
chr8_109674261_109674444 0.25 TMEM74
 transmembrane protein 74
 125492
 0.06
chr5_68463336_68463586 0.25 CCNB1
 cyclin B1
 371
 0.77
chr12_26888585_26888736 0.25 ITPR2
 inositol 1,4,5-trisphosphate receptor, type 2
 97054
 0.07
chr16_4850786_4851082 0.25 ROGDI
 rogdi homolog (Drosophila)
 355
 0.77
chr9_77112278_77112453 0.25 RORB
 RAR-related orphan receptor B
 84
 0.97
chr4_173707980_173708237 0.25 ENSG00000241652
 .
 354686
 0.01
chr15_50404931_50405220 0.25 ATP8B4
 ATPase, class I, type 8B, member 4
 1626
 0.45
chr5_150477986_150478137 0.25 TNIP1
 TNFAIP3 interacting protein 1
 4923
 0.21
chr1_197170977_197171128 0.24 CRB1
 crumbs homolog 1 (Drosophila)
 460
 0.77
chr6_14744067_14744218 0.24 ENSG00000206960
 .
 97376
 0.09
chr12_116757651_116758051 0.24 MED13L
 mediator complex subunit 13-like
 42708
 0.16
chr6_6857532_6857683 0.24 ENSG00000240936
 .
 81523
 0.11
chr5_75992073_75992255 0.24 F2R
 coagulation factor II (thrombin) receptor
 19704
 0.16
chr4_60684323_60684624 0.24 ENSG00000201676
 .
 14420
 0.24
chr7_18184166_18184423 0.24 ENSG00000221393
 .
 17362
 0.24
chr4_105979647_105979990 0.24 ENSG00000252136
 .
 47326
 0.16
chr20_44509523_44509687 0.24 ZSWIM1
 zinc finger, SWIM-type containing 1
 261
 0.8
chr1_180248686_180248990 0.24 RP5-1180C10.2
3479
 0.3
chr3_29194998_29195333 0.24 RBMS3
 RNA binding motif, single stranded interacting protein 3
 127308
 0.05
chr4_146540899_146541050 0.24 MMAA
 methylmalonic aciduria (cobalamin deficiency) cblA type
 1559
 0.42
chr12_121019480_121019828 0.24 POP5
 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
 453
 0.74
chr3_169720111_169720354 0.24 SEC62-AS1
 SEC62 antisense RNA 1
 16729
 0.13
chr19_15054504_15054655 0.24 OR7C2
 olfactory receptor, family 7, subfamily C, member 2
 2278
 0.26
chrX_15448302_15448453 0.24 BMX
 BMX non-receptor tyrosine kinase
 33992
 0.15
chr1_45023108_45023259 0.24 ENSG00000263381
 .
 12018
 0.2
chr2_145443692_145443848 0.24 ZEB2
 zinc finger E-box binding homeobox 2
 165149
 0.04
chr10_125865907_125866246 0.24 CHST15
 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
 12870
 0.28
chr1_181056660_181057120 0.23 IER5
 immediate early response 5
 748
 0.71
chr2_148779503_148779985 0.23 ORC4
 origin recognition complex, subunit 4
 597
 0.65
chr2_118856015_118856215 0.23 INSIG2
 insulin induced gene 2
 10065
 0.24
chr3_128313216_128313433 0.23 C3orf27
 chromosome 3 open reading frame 27
 18395
 0.19
chr15_69075380_69075658 0.23 ENSG00000265195
 .
 18745
 0.22
chr10_45874886_45875037 0.23 ALOX5
 arachidonate 5-lipoxygenase
 5286
 0.27
chr6_21589300_21589525 0.23 SOX4
 SRY (sex determining region Y)-box 4
 4560
 0.37
chr8_102923998_102924149 0.23 NCALD
 neurocalcin delta
 63484
 0.13
chrX_13754467_13754844 0.23 OFD1
 oral-facial-digital syndrome 1
 1791
 0.29
chr7_100011522_100011687 0.23 ZCWPW1
 zinc finger, CW type with PWWP domain 1
 4436
 0.09
chr22_36556784_36556935 0.23 APOL3
 apolipoprotein L, 3
 28
 0.98
chr1_46052215_46052366 0.23 NASP
 nuclear autoantigenic sperm protein (histone-binding)
 2553
 0.23
chr2_176495143_176495353 0.23 AC016751.3
266816
 0.01
chr17_79360953_79361175 0.23 RP11-1055B8.6
 Uncharacterized protein
 8211
 0.12
chr13_105829604_105829896 0.23 DAOA
 D-amino acid oxidase activator
 288842
 0.01
chr16_28518181_28518332 0.23 IL27
 interleukin 27
 101
 0.95
chr9_33759387_33759538 0.23 PRSS3
 protease, serine, 3
 8643
 0.14
chr19_14877311_14877462 0.23 EMR2
 egf-like module containing, mucin-like, hormone receptor-like 2
 5800
 0.16
chr11_66115431_66115582 0.23 RP11-867G23.8
 Uncharacterized protein
 85
 0.76
chr4_85888329_85888497 0.23 WDFY3
 WD repeat and FYVE domain containing 3
 869
 0.72
chr12_57773877_57774028 0.23 ENSG00000201198
 .
 35127
 0.09
chr1_85411015_85411201 0.23 MCOLN2
 mucolipin 2
 51515
 0.12
chr17_1992881_1993032 0.23 RP11-667K14.5
19
 0.96
chr17_59940538_59940689 0.22 BRIP1
 BRCA1 interacting protein C-terminal helicase 1
 92
 0.97
chr4_4292418_4292569 0.22 ZBTB49
 zinc finger and BTB domain containing 49
 497
 0.52
chr17_58754505_58754656 0.22 BCAS3
 breast carcinoma amplified sequence 3
 234
 0.92
chrX_13770949_13771164 0.22 OFD1
 oral-facial-digital syndrome 1
 18192
 0.17
chrX_16846441_16846592 0.22 RBBP7
 retinoblastoma binding protein 7
 23672
 0.15
chr17_30214979_30215206 0.22 UTP6
 UTP6, small subunit (SSU) processome component, homolog (yeast)
 13692
 0.18
chr9_33221071_33221222 0.22 SPINK4
 serine peptidase inhibitor, Kazal type 4
 169
 0.94
chr11_108095836_108095987 0.22 ATM
 ataxia telangiectasia mutated
 1106
 0.42
chr15_52733385_52733536 0.22 MYO5A
 myosin VA (heavy chain 12, myoxin)
 5593
 0.28
chr12_53937677_53937943 0.22 RP11-793H13.3
30042
 0.1
chr11_128554939_128555157 0.22 RP11-744N12.3
1275
 0.35
chr1_20959712_20959863 0.22 PINK1
 PTEN induced putative kinase 1
 161
 0.95
chr6_611011_611162 0.22 HUS1B
 HUS1 checkpoint homolog b (S. pombe)
 45877
 0.17
chr1_228328808_228329114 0.22 GUK1
 guanylate kinase 1
 122
 0.93
chr6_5999961_6000211 0.22 NRN1
 neuritin 1
 7114
 0.26
chr1_89150817_89151520 0.22 RP11-76N22.2
281
 0.84
chr6_35697474_35697939 0.22 FKBP5
 FK506 binding protein 5
 1346
 0.31
chr11_47972062_47972213 0.22 PTPRJ
 protein tyrosine phosphatase, receptor type, J
 29976
 0.17
chr6_106546899_106547210 0.21 PRDM1
 PR domain containing 1, with ZNF domain
 239
 0.88
chr5_137679824_137679975 0.21 RP11-256P1.1
5431
 0.13
chr18_20722941_20723198 0.21 ENSG00000222999
 .
 6593
 0.21
chr4_169239823_169239974 0.21 DDX60
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
 57
 0.98
chr10_126430141_126430442 0.21 FAM53B
 family with sequence similarity 53, member B
 1248
 0.43
chr22_19465272_19465744 0.21 UFD1L
 ubiquitin fusion degradation 1 like (yeast)
 946
 0.35
chr18_74162951_74163102 0.21 ZNF516
 zinc finger protein 516
 39709
 0.14
chr10_82215641_82216144 0.21 TSPAN14
 tetraspanin 14
 1781
 0.38
chr9_127005358_127005801 0.21 NEK6
 NIMA-related kinase 6
 14306
 0.17
chr3_135912382_135912568 0.21 MSL2
 male-specific lethal 2 homolog (Drosophila)
 921
 0.68
chr4_125624499_125624650 0.21 ANKRD50
 ankyrin repeat domain 50
 9313
 0.34
chr12_22830855_22831006 0.21 ETNK1
 ethanolamine kinase 1
 52639
 0.15
chr3_176919574_176920023 0.21 TBL1XR1
 transducin (beta)-like 1 X-linked receptor 1
 4537
 0.31
chr1_26450910_26451453 0.21 PDIK1L
 PDLIM1 interacting kinase 1 like
 12841
 0.11
chr19_54559994_54560145 0.21 VSTM1
 V-set and transmembrane domain containing 1
 1608
 0.22
chr1_42195372_42195655 0.21 HIVEP3
 human immunodeficiency virus type I enhancer binding protein 3
 28841
 0.2
chr1_151668701_151668852 0.21 RP11-98D18.1
4726
 0.1
chr5_159698543_159698722 0.21 ENSG00000243654
 .
 20163
 0.16
chr3_128583649_128583920 0.21 RP11-723O4.2
663
 0.69
chr17_59222293_59222572 0.21 RP11-136H19.1
9107
 0.23
chr16_48644531_48644682 0.20 N4BP1
 NEDD4 binding protein 1
 486
 0.81
chr3_71731013_71731282 0.20 EIF4E3
 eukaryotic translation initiation factor 4E family member 3
 43379
 0.15
chrX_109280296_109280497 0.20 ENSG00000208013
 .
 18161
 0.2
chr9_92020971_92021287 0.20 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 288
 0.93
chr7_116594399_116594611 0.20 ST7
 suppression of tumorigenicity 7
 60
 0.54
chr11_128089678_128089829 0.20 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 285536
 0.01
chrX_9547118_9547269 0.20 TBL1X
 transducin (beta)-like 1X-linked
 44210
 0.2
chr15_50345522_50345833 0.20 ATP8B4
 ATPase, class I, type 8B, member 4
 6093
 0.27
chr1_21292036_21292187 0.20 EIF4G3
 eukaryotic translation initiation factor 4 gamma, 3
 7418
 0.23
chr2_145275679_145275945 0.20 ZEB2
 zinc finger E-box binding homeobox 2
 16
 0.51
chr10_65388709_65389027 0.20 REEP3
 receptor accessory protein 3
 107745
 0.07
chr9_132682421_132682638 0.20 FNBP1
 formin binding protein 1
 940
 0.56
chr9_113096398_113096701 0.20 TXNDC8
 thioredoxin domain containing 8 (spermatozoa)
 3539
 0.28
chr2_210852878_210853031 0.20 RPE
 ribulose-5-phosphate-3-epimerase
 14335
 0.18
chr16_54210277_54210428 0.20 RP11-324D17.1
 HCG2045435; Uncharacterized protein
 70525
 0.11
chr8_124170086_124170384 0.20 FAM83A
 family with sequence similarity 83, member A
 21052
 0.11
chr22_25782542_25782779 0.20 LRP5L
 low density lipoprotein receptor-related protein 5-like
 5116
 0.24
chr2_169957115_169957325 0.20 AC007556.3
33
 0.98
chr7_150104070_150104221 0.20 RP4-584D14.6
23172
 0.11
chr1_212809981_212810132 0.20 RP11-338C15.5
9943
 0.14
chr9_35569725_35569931 0.20 FAM166B
 family with sequence similarity 166, member B
 5932
 0.12
chr2_237973979_237974130 0.20 AC105760.3
9244
 0.19
chr12_33047562_33047713 0.20 PKP2
 plakophilin 2
 2053
 0.46
chr6_2838201_2838352 0.20 SERPINB1
 serpin peptidase inhibitor, clade B (ovalbumin), member 1
 3818
 0.22
chr1_65522143_65522294 0.20 ENSG00000265996
 .
 1307
 0.39
chr15_68502161_68502336 0.20 CALML4
 calmodulin-like 4
 3831
 0.2
chr10_7449534_7449830 0.20 SFMBT2
 Scm-like with four mbt domains 2
 1025
 0.67
chr14_106679120_106679271 0.19 IGHVII-20-1
 immunoglobulin heavy variable (II)-20-1 (pseudogene)
 9244
 0.05
chr3_138954177_138954328 0.19 MRPS22
 mitochondrial ribosomal protein S22
 108609
 0.06
chr8_128887727_128887885 0.19 TMEM75
 transmembrane protein 75
 72785
 0.09
chr5_101622831_101622982 0.19 SLCO4C1
 solute carrier organic anion transporter family, member 4C1
 9347
 0.21
chr2_55747454_55747845 0.19 CCDC104
 coiled-coil domain containing 104
 782
 0.58
chr14_70172450_70172635 0.19 SRSF5
 serine/arginine-rich splicing factor 5
 21075
 0.22
chr19_14186633_14186784 0.19 hsa-mir-1199
 hsa-mir-1199
 2314
 0.15
chr7_48498957_48499108 0.19 ABCA13
 ATP-binding cassette, sub-family A (ABC1), member 13
 4372
 0.37

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1 0.2 GO:0072110 glomerular mesangial cell proliferation(GO:0072110) regulation of glomerular mesangial cell proliferation(GO:0072124)
0.1 0.2 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.1 0.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 0.2 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1 0.2 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.2 GO:0045625 regulation of T-helper 1 cell differentiation(GO:0045625)
0.0 0.2 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.2 GO:0018101 protein citrullination(GO:0018101)
0.0 0.1 GO:0070423 cytoplasmic pattern recognition receptor signaling pathway(GO:0002753) nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway(GO:0035872) nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.0 0.1 GO:2000143 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.1 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.1 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.2 GO:0033688 regulation of osteoblast proliferation(GO:0033688)
0.0 0.1 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.2 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.2 GO:0002360 T cell lineage commitment(GO:0002360)
0.0 0.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0021860 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.0 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.1 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.1 GO:0060287 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.3 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.4 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.1 GO:0002713 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0 0.1 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 0.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.2 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.1 GO:0043374 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.1 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.0 0.1 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.0 0.1 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.1 GO:1901798 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.2 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.1 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.0 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.0 GO:0032239 regulation of nucleobase-containing compound transport(GO:0032239)
0.0 0.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.1 GO:0035751 lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0 0.1 GO:0045885 obsolete positive regulation of survival gene product expression(GO:0045885)
0.0 0.1 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.1 GO:0018243 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.0 GO:0060872 semicircular canal development(GO:0060872)
0.0 0.1 GO:0000132 establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0 0.1 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.0 0.0 GO:0071803 regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0 0.0 GO:0060737 prostate gland morphogenetic growth(GO:0060737)
0.0 0.0 GO:0003078 obsolete regulation of natriuresis(GO:0003078)
0.0 0.1 GO:0032727 positive regulation of interferon-alpha production(GO:0032727)
0.0 0.0 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.0 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.0 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.1 GO:0071501 SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.0 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0 0.1 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.0 0.1 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.1 GO:0035608 protein deglutamylation(GO:0035608)
0.0 0.1 GO:0015671 oxygen transport(GO:0015671)
0.0 0.0 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.2 GO:0007379 segment specification(GO:0007379)
0.0 0.0 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.1 GO:0034405 response to fluid shear stress(GO:0034405)
0.0 0.0 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.2 GO:0042255 ribosome assembly(GO:0042255)
0.0 0.0 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.0 GO:1903429 regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.0 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.0 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.0 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0008653 lipopolysaccharide metabolic process(GO:0008653)
0.0 0.2 GO:0001893 maternal placenta development(GO:0001893)
0.0 0.0 GO:0006991 response to sterol depletion(GO:0006991)
0.0 0.0 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.1 GO:0021903 rostrocaudal neural tube patterning(GO:0021903) midbrain-hindbrain boundary development(GO:0030917)
0.0 0.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.0 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0 0.1 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.2 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.0 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0 0.1 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.0 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.1 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 0.0 GO:0006533 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.0 GO:0007000 nucleolus organization(GO:0007000)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.1 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.2 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.0 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0032009 early phagosome(GO:0032009)
0.0 0.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.2 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0031094 platelet dense tubular network(GO:0031094)
0.0 0.0 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.0 GO:0070852 cell body fiber(GO:0070852)
0.0 0.3 GO:0005776 autophagosome(GO:0005776)
0.0 0.0 GO:0035098 ESC/E(Z) complex(GO:0035098)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.3 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.3 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.2 GO:0035173 histone kinase activity(GO:0035173)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0035197 siRNA binding(GO:0035197)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.2 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.0 0.2 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0008159 obsolete positive transcription elongation factor activity(GO:0008159)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.3 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.0 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.0 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.0 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.1 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.0 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.0 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.0 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.0 GO:0046980 tapasin binding(GO:0046980)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0070402 NADPH binding(GO:0070402)
0.0 0.0 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.5 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.0 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.0 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.0 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.1 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.3 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.4 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.2 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.4 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.0 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.2 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling