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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for IRF7
Z-value: 1.74
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Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:
This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.
For each TF, only the top 5 correlated CREs are shown.
| CRE | Gene | Distance | Association probability | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|---|---|
| chr11_612909_613060 | IRF7 | 2642 | 0.119978 | -0.49 | 1.8e-01 | Click! |
| chr11_614044_614195 | IRF7 | 1507 | 0.197318 | -0.40 | 2.9e-01 | Click! |
| chr11_614285_614786 | IRF7 | 1091 | 0.280942 | -0.40 | 2.9e-01 | Click! |
| chr11_615175_615598 | IRF7 | 240 | 0.825669 | -0.41 | 2.8e-01 | Click! |
| chr11_616483_616687 | IRF7 | 586 | 0.523899 | -0.39 | 2.9e-01 | Click! |
Showing 1 to 5 of 5 entries
Top target CREs of the motif:
| Cis Regulatory Element (CRE) | Target Score | Top associated gene | Gene Info | Distance of CRE to TSS | CRE/Gene association probability |
|---|---|---|---|---|---|
| chr10_62485533_62485684 | 0.49 |
ANK3 |
ankyrin 3, node of Ranvier (ankyrin G) |
7640 |
0.29 |
| chr8_22319793_22319944 | 0.45 |
PPP3CC |
protein phosphatase 3, catalytic subunit, gamma isozyme |
13237 |
0.15 |
| chrX_30849441_30849592 | 0.44 |
TAB3-AS1 |
TAB3 antisense RNA 1 |
3224 |
0.24 |
| chr2_7590065_7590353 | 0.42 |
ENSG00000221255 |
. |
126763 |
0.06 |
| chr1_3807784_3807950 | 0.42 |
ENSG00000264428 |
. |
7239 |
0.16 |
| chr16_89486895_89487046 | 0.41 |
RP1-168P16.1 |
|
1664 |
0.28 |
| chr14_77249034_77249359 | 0.40 |
RP11-488C13.6 |
|
1335 |
0.4 |
| chr4_47829536_47829942 | 0.40 |
CORIN |
corin, serine peptidase |
10227 |
0.21 |
| chr5_39212456_39212665 | 0.39 |
FYB |
FYN binding protein |
7105 |
0.3 |
| chr1_78506342_78506493 | 0.38 |
GIPC2 |
GIPC PDZ domain containing family, member 2 |
5169 |
0.18 |
Histogram of CRE-TSS distances for CREs targeted by :
Rank distribution of CRE target scores:
Distribution of target CREs across different genomic regions:
Network of associatons between targets according to the STRING database.
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 0.9 | GO:0031294 | lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295) |
| 0.2 | 0.8 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 0.2 | 0.8 | GO:0001911 | negative regulation of leukocyte mediated cytotoxicity(GO:0001911) |
| 0.0 | 0.8 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.1 | 0.7 | GO:0002837 | regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839) |
| 0.2 | 0.6 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.2 | 0.6 | GO:0045589 | regulation of regulatory T cell differentiation(GO:0045589) |
| 0.1 | 0.6 | GO:0033152 | immunoglobulin V(D)J recombination(GO:0033152) |
| 0.1 | 0.6 | GO:0007172 | signal complex assembly(GO:0007172) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 1.0 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 0.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 0.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.6 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 0.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 0.5 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.1 | 0.5 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.0 | 0.5 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.5 | GO:0005876 | spindle microtubule(GO:0005876) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 1.5 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 1.3 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 1.2 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 1.2 | GO:0101005 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.1 | 1.1 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.0 | 1.0 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.9 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 0.7 | GO:0034593 | phosphatidylinositol bisphosphate phosphatase activity(GO:0034593) |
| 0.0 | 0.7 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 2.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 1.5 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.3 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.0 | 1.1 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 1.0 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 1.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 0.7 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 0.6 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.6 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 1.5 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 1.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 1.3 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 1.3 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.1 | 1.1 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 1.0 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.9 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.0 | 0.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.8 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |