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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for IRF7

Z-value: 1.74

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Transcription factors associated with IRF7

Gene Symbol	Gene ID	Gene Info
IRF7 Ensembl NCBI GeneCards UniProt	ENSG00000185507.15	interferon regulatory factor 7

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr11_612909_613060	IRF7	2642	0.119978	-0.49	1.8e-01	Click!
chr11_615175_615598	IRF7	240	0.825669	-0.41	2.8e-01	Click!
chr11_614285_614786	IRF7	1091	0.280942	-0.40	2.9e-01	Click!
chr11_614044_614195	IRF7	1507	0.197318	-0.40	2.9e-01	Click!
chr11_616483_616687	IRF7	586	0.523899	-0.39	2.9e-01	Click!

Activity of the IRF7 motif across conditions

Conditions sorted by the z-value of the IRF7 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_62485533_62485684	0.49	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	7640	0.29
chr8_22319793_22319944	0.45	PPP3CC	protein phosphatase 3, catalytic subunit, gamma isozyme	13237	0.15
chrX_30849441_30849592	0.44	TAB3-AS1	TAB3 antisense RNA 1	3224	0.24
chr2_7590065_7590353	0.42	ENSG00000221255	.	126763	0.06
chr1_3807784_3807950	0.42	ENSG00000264428	.	7239	0.16
chr16_89486895_89487046	0.41	RP1-168P16.1		1664	0.28
chr14_77249034_77249359	0.40	RP11-488C13.6		1335	0.4
chr4_47829536_47829942	0.40	CORIN	corin, serine peptidase	10227	0.21
chr5_39212456_39212665	0.39	FYB	FYN binding protein	7105	0.3
chr1_78506342_78506493	0.38	GIPC2	GIPC PDZ domain containing family, member 2	5169	0.18
chr2_222420598_222420749	0.38	EPHA4	EPH receptor A4	13528	0.21
chr6_90919138_90919289	0.37	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	87248	0.09
chr15_22460371_22460742	0.36	AC010760.1		3661	0.15
chr1_226915533_226915684	0.35	ITPKB	inositol-trisphosphate 3-kinase B	9551	0.23
chr7_138747161_138747312	0.35	ZC3HAV1	zinc finger CCCH-type, antiviral 1	16777	0.19
chr1_46528401_46528573	0.34	RP4-533D7.4		15997	0.19
chr2_221511090_221511465	0.34	ENSG00000222096	.	169464	0.04
chr1_84631383_84631693	0.34	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	889	0.71
chr13_40397431_40397658	0.34	ENSG00000212553	.	33820	0.19
chr6_24894743_24895047	0.34	FAM65B	family with sequence similarity 65, member B	16300	0.2
chr5_94959224_94959533	0.33	GPR150	G protein-coupled receptor 150	3596	0.22
chr6_79779968_79780119	0.33	PHIP	pleckstrin homology domain interacting protein	7910	0.3
chr7_142420927_142421220	0.33	PRSS1	protease, serine, 1 (trypsin 1)	36246	0.15
chr5_49624700_49624851	0.33	EMB	embigin	99786	0.09
chr5_14707723_14707985	0.33	FAM105B	family with sequence similarity 105, member B	26195	0.18
chr10_24911730_24912041	0.33	ARHGAP21	Rho GTPase activating protein 21	122	0.97
chr12_112430467_112430685	0.33	TMEM116	transmembrane protein 116	13213	0.16
chr4_102339739_102340117	0.33	BANK1	B-cell scaffold protein with ankyrin repeats 1	1190	0.58
chr1_210513819_210514027	0.32	HHAT	hedgehog acyltransferase	11279	0.24
chr6_112069105_112069276	0.31	FYN	FYN oncogene related to SRC, FGR, YES	11127	0.26
chr12_113699598_113700042	0.31	TPCN1	two pore segment channel 1	1713	0.31
chr7_37381820_37382186	0.31	ELMO1	engulfment and cell motility 1	364	0.89
chr1_243517987_243518270	0.31	ENSG00000265201	.	8650	0.26
chr10_126628223_126628374	0.31	ZRANB1	zinc finger, RAN-binding domain containing 1	2394	0.26
chr8_29945094_29945295	0.31	TMEM66	transmembrane protein 66	4471	0.16
chr13_41186364_41186802	0.31	FOXO1	forkhead box O1	54151	0.14
chr10_27312984_27313135	0.31	ANKRD26	ankyrin repeat domain 26	9451	0.23
chr16_85137134_85137337	0.30	FAM92B	family with sequence similarity 92, member B	8879	0.21
chr5_32280871_32281022	0.30	ENSG00000207052	.	28822	0.15
chr14_22520830_22521052	0.30	ENSG00000238634	.	89946	0.09
chr1_168391686_168391980	0.30	ENSG00000207974	.	47071	0.16
chr2_137039834_137039985	0.30	ENSG00000251976	.	107993	0.07
chr2_36472218_36472369	0.30	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	110776	0.07
chr5_54871894_54872045	0.30	PPAP2A	phosphatidic acid phosphatase type 2A	41091	0.16
chr8_71132477_71132643	0.29	NCOA2	nuclear receptor coactivator 2	25050	0.23
chrX_70858439_70858590	0.29	ENSG00000264855	.	12809	0.19
chr7_127496048_127496199	0.29	SND1	staphylococcal nuclease and tudor domain containing 1	31842	0.22
chr12_8796592_8796884	0.29	MFAP5	microfibrillar associated protein 5	6412	0.15
chr10_8286398_8286634	0.29	GATA3	GATA binding protein 3	189747	0.03
chrX_131176275_131176426	0.29	MST4	Serine/threonine-protein kinase MST4	18714	0.21
chr14_20950095_20950246	0.29	PNP	purine nucleoside phosphorylase	11485	0.09
chr21_32531106_32531735	0.29	TIAM1	T-cell lymphoma invasion and metastasis 1	28881	0.23
chr15_81075671_81075822	0.29	KIAA1199	KIAA1199	4034	0.27
chr12_92579451_92579773	0.29	ENSG00000199895	.	15383	0.19
chr5_158838364_158838658	0.29	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	80616	0.09
chr3_107788734_107788929	0.28	CD47	CD47 molecule	10452	0.3
chr10_17471175_17471536	0.28	ST8SIA6-AS1	ST8SIA6 antisense RNA 1	21329	0.17
chr1_116013920_116014071	0.28	ENSG00000265534	.	14277	0.26
chr18_52384635_52384905	0.28	RAB27B	RAB27B, member RAS oncogene family	321	0.94
chr16_50815719_50815971	0.28	CYLD	cylindromatosis (turban tumor syndrome)	11683	0.13
chr3_112644879_112645030	0.28	CD200R1	CD200 receptor 1	48805	0.11
chr6_35278431_35279308	0.28	DEF6	differentially expressed in FDCP 6 homolog (mouse)	1354	0.42
chr18_9134459_9134610	0.28	RP11-143J12.2		1114	0.39
chr22_40448857_40449008	0.28	TNRC6B	trinucleotide repeat containing 6B	7454	0.19
chr6_20680920_20681105	0.28	RP3-348I23.2		119913	0.06
chr2_202104224_202104480	0.27	CASP8	caspase 8, apoptosis-related cysteine peptidase	6123	0.2
chr17_46928469_46928620	0.27	CALCOCO2	calcium binding and coiled-coil domain 2	1779	0.24
chr18_23808202_23808446	0.27	TAF4B	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa	1874	0.39
chr1_90095113_90095264	0.27	RP11-413E1.4		96	0.96
chr6_36022024_36022175	0.27	MAPK14	mitogen-activated protein kinase 14	25233	0.16
chr1_52888786_52889059	0.27	ZCCHC11	zinc finger, CCHC domain containing 11	7831	0.14
chr1_179111025_179111189	0.27	ABL2	c-abl oncogene 2, non-receptor tyrosine kinase	1072	0.55
chr14_75741894_75742142	0.27	FOS	FBJ murine osteosarcoma viral oncogene homolog	3459	0.19
chr2_43793678_43793972	0.27	THADA	thyroid adenoma associated	3829	0.29
chr20_8132706_8132867	0.27	PLCB1	phospholipase C, beta 1 (phosphoinositide-specific)	19484	0.25
chr11_59535226_59535396	0.27	STX3	syntaxin 3	12386	0.14
chr6_112339019_112339170	0.27	WISP3	WNT1 inducible signaling pathway protein 3	36181	0.17
chr15_29285508_29285659	0.27	APBA2	amyloid beta (A4) precursor protein-binding, family A, member 2	2961	0.31
chr15_44963137_44963303	0.27	PATL2	protein associated with topoisomerase II homolog 2 (yeast)	2537	0.22
chr2_233942870_233943259	0.27	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	17875	0.18
chr14_50091090_50091241	0.27	RP11-649E7.5		967	0.31
chr12_12165065_12165501	0.27	BCL2L14	BCL2-like 14 (apoptosis facilitator)	37495	0.2
chr20_23603657_23603876	0.27	CST3	cystatin C	14816	0.16
chr10_104006886_104007037	0.26	GBF1	golgi brefeldin A resistant guanine nucleotide exchange factor 1	1672	0.28
chr14_92466123_92466310	0.26	TRIP11	thyroid hormone receptor interactor 11	15879	0.18
chr18_67556534_67556685	0.26	CD226	CD226 molecule	58046	0.15
chr6_157293950_157294101	0.26	ARID1B	AT rich interactive domain 1B (SWI1-like)	71518	0.13
chr4_78514206_78514375	0.26	CXCL13	chemokine (C-X-C motif) ligand 13	81383	0.1
chr4_57251327_57251478	0.26	AASDH	aminoadipate-semialdehyde dehydrogenase	2187	0.26
chr6_128392441_128392592	0.26	PTPRK	protein tyrosine phosphatase, receptor type, K	6608	0.28
chr6_56753269_56753420	0.26	DST	dystonin	36595	0.15
chr7_37404005_37404156	0.26	ELMO1	engulfment and cell motility 1	10808	0.2
chr12_21797443_21797594	0.26	LDHB	lactate dehydrogenase B	12778	0.18
chr1_174846351_174846502	0.26	RABGAP1L	RAB GTPase activating protein 1-like	152	0.96
chr18_68327050_68327270	0.26	GTSCR1	Gilles de la Tourette syndrome chromosome region, candidate 1	9180	0.32
chr3_190163992_190164143	0.26	TMEM207	transmembrane protein 207	3598	0.3
chr8_77908172_77908323	0.26	PEX2	peroxisomal biogenesis factor 2	4215	0.3
chr5_79447122_79447273	0.26	CTC-458I2.2		23013	0.19
chr1_101587391_101587816	0.26	ENSG00000252765	.	11106	0.2
chr5_141506960_141507157	0.26	NDFIP1	Nedd4 family interacting protein 1	18988	0.23
chr9_77748055_77748206	0.26	OSTF1	osteoclast stimulating factor 1	44671	0.12
chr12_9819965_9820194	0.25	CLEC2D	C-type lectin domain family 2, member D	2230	0.2
chr2_173311272_173311492	0.25	AC078883.4		18051	0.16
chr20_31550936_31551087	0.25	EFCAB8	EF-hand calcium binding domain 8	3360	0.22
chr3_151922708_151922859	0.25	MBNL1	muscleblind-like splicing regulator 1	63046	0.13
chr8_22395996_22396147	0.25	RP11-582J16.4		6847	0.12
chr8_59997705_59997856	0.25	RP11-25K19.1		33819	0.16
chr9_112732681_112732832	0.25	AKAP2	A kinase (PRKA) anchor protein 2	78122	0.1
chr6_112089861_112090078	0.25	FYN	FYN oncogene related to SRC, FGR, YES	8849	0.28
chrX_135724911_135725077	0.25	ENSG00000233093	.	3168	0.22
chr5_43015531_43015857	0.25	CTD-2035E11.3		2837	0.21
chr16_50310797_50310948	0.25	ADCY7	adenylate cyclase 7	2566	0.29
chr15_25657849_25658000	0.25	UBE3A	ubiquitin protein ligase E3A	4129	0.15
chr5_169820347_169820594	0.25	KCNMB1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	3789	0.22
chr12_92949909_92950139	0.24	ENSG00000238865	.	11261	0.26
chr1_214483462_214483613	0.24	SMYD2	SET and MYND domain containing 2	20783	0.24
chr18_74863406_74863557	0.24	MBP	myelin basic protein	18681	0.27
chr2_218458844_218459122	0.24	DIRC3	disrupted in renal carcinoma 3	162295	0.04
chr7_96466534_96466857	0.24	ENSG00000244318	.	102981	0.07
chr5_80302145_80302296	0.24	CTC-459I6.1		45494	0.15
chr3_136636143_136636557	0.24	NCK1	NCK adaptor protein 1	10531	0.19
chr1_25995461_25995725	0.24	RP1-187B23.1		9991	0.19
chr2_65352077_65352228	0.24	RAB1A	RAB1A, member RAS oncogene family	5083	0.22
chr10_7088660_7089557	0.24	SFMBT2	Scm-like with four mbt domains 2	361599	0.01
chr12_92796935_92797431	0.24	RP11-693J15.4		18124	0.18
chr12_124422307_124422553	0.24	RP11-380L11.3		1677	0.17
chr2_190239203_190239436	0.24	ENSG00000266817	.	62832	0.12
chr5_50030005_50030180	0.24	PARP8	poly (ADP-ribose) polymerase family, member 8	66701	0.15
chr13_36907252_36907436	0.24	SPG20	spastic paraplegia 20 (Troyer syndrome)	13076	0.13
chr12_92425801_92426181	0.24	C12orf79	chromosome 12 open reading frame 79	104806	0.07
chr10_76633934_76634174	0.24	KAT6B	K(lysine) acetyltransferase 6B	35596	0.21
chr12_21831996_21832380	0.24	RP11-59N23.3		16941	0.18
chr11_104519828_104519979	0.24	CASP12	caspase 12 (gene/pseudogene)	249238	0.02
chr7_8181558_8181709	0.24	ENSG00000265212	.	13019	0.21
chr3_180651200_180651351	0.24	FXR1	fragile X mental retardation, autosomal homolog 1	18027	0.21
chr7_38348883_38349236	0.24	STARD3NL	STARD3 N-terminal like	131062	0.05
chr9_77766078_77766231	0.24	ENSG00000200041	.	30383	0.16
chr7_81514083_81514336	0.24	ENSG00000263416	.	35377	0.21
chr1_205595237_205595704	0.24	ELK4	ELK4, ETS-domain protein (SRF accessory protein 1)	5620	0.17
chr7_37403219_37403780	0.24	ELMO1	engulfment and cell motility 1	10227	0.2
chr1_121348654_121348844	0.24	FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)	412812	0.01
chr11_121162107_121162258	0.24	SC5D	sterol-C5-desaturase	980	0.7
chr6_49519591_49519742	0.24	C6orf141	chromosome 6 open reading frame 141	1553	0.44
chr9_13377222_13377373	0.24	MPDZ	multiple PDZ domain protein	97708	0.08
chrX_40140473_40140823	0.24	ENSG00000238920	.	3701	0.36
chr15_38958428_38958579	0.24	C15orf53	chromosome 15 open reading frame 53	30296	0.22
chr1_92789162_92789478	0.24	GLMN	glomulin, FKBP associated protein	24776	0.17
chr3_156201288_156201439	0.24	KCNAB1-AS1	KCNAB1 antisense RNA 1	36669	0.17
chr19_50407502_50407838	0.24	IL4I1	interleukin 4 induced 1	7458	0.06
chr14_52331443_52331710	0.24	GNG2	guanine nucleotide binding protein (G protein), gamma 2	3534	0.26
chr1_11028360_11028511	0.24	C1orf127	chromosome 1 open reading frame 127	4177	0.17
chr12_15715155_15715553	0.24	PTPRO	protein tyrosine phosphatase, receptor type, O	16068	0.26
chrX_78519115_78519266	0.24	GPR174	G protein-coupled receptor 174	92721	0.09
chrX_123138511_123138662	0.24	STAG2	stromal antigen 2	41566	0.17
chr2_197046557_197046870	0.24	STK17B	serine/threonine kinase 17b	5486	0.21
chr9_139135589_139135794	0.24	QSOX2	quiescin Q6 sulfhydryl oxidase 2	1996	0.31
chr3_108021242_108021538	0.24	HHLA2	HERV-H LTR-associating 2	58	0.98
chr8_133533629_133533893	0.23	KCNQ3	potassium voltage-gated channel, KQT-like subfamily, member 3	40561	0.19
chr1_220414638_220414789	0.23	RAB3GAP2	RAB3 GTPase activating protein subunit 2 (non-catalytic)	29994	0.17
chr2_26016237_26016499	0.23	ASXL2	additional sex combs like 2 (Drosophila)	13190	0.24
chr2_196446250_196446401	0.23	SLC39A10	solute carrier family 39 (zinc transporter), member 10	5624	0.29
chr12_9104317_9104548	0.23	KLRG1	killer cell lectin-like receptor subfamily G, member 1	1792	0.26
chr13_30852418_30852661	0.23	ENSG00000252928	.	3363	0.3
chr1_151427104_151427255	0.23	POGZ	pogo transposable element with ZNF domain	354	0.81
chr2_169032889_169033150	0.23	STK39	serine threonine kinase 39	71632	0.13
chr12_96537632_96537783	0.23	ENSG00000266889	.	41680	0.13
chr9_90323622_90323773	0.23	CTSL	cathepsin L	16737	0.2
chr6_157420488_157420639	0.23	RP1-137K2.2		20277	0.25
chr6_112157210_112157486	0.23	FYN	FYN oncogene related to SRC, FGR, YES	8799	0.29
chr20_13210302_13210453	0.23	ISM1	isthmin 1, angiogenesis inhibitor	7959	0.2
chr6_142716433_142716768	0.23	GPR126	G protein-coupled receptor 126	5151	0.33
chr13_74625480_74625801	0.23	KLF12	Kruppel-like factor 12	56454	0.17
chr1_226178883_226179034	0.23	SDE2	SDE2 telomere maintenance homolog (S. pombe)	8074	0.16
chr22_40513966_40514117	0.23	TNRC6B	trinucleotide repeat containing 6B	59888	0.12
chr3_118945056_118945207	0.23	B4GALT4-AS1	B4GALT4 antisense RNA 1	202	0.93
chr17_76815501_76815673	0.23	USP36	ubiquitin specific peptidase 36	3744	0.21
chr1_249110651_249111042	0.23	SH3BP5L	SH3-binding domain protein 5-like	426	0.79
chr4_40207228_40207547	0.23	RHOH	ras homolog family member H	5423	0.24
chr15_75897408_75897633	0.23	SNUPN	snurportin 1	12345	0.11
chr3_190025299_190025450	0.23	CLDN1	claudin 1	14890	0.24
chr19_47649979_47650273	0.23	SAE1	SUMO1 activating enzyme subunit 1	15974	0.15
chr17_73080067_73080518	0.23	SLC16A5	solute carrier family 16 (monocarboxylate transporter), member 5	3530	0.11
chr7_132120161_132120457	0.23	AC011625.1		83216	0.1
chr6_28490581_28490732	0.23	GPX5	glutathione peroxidase 5 (epididymal androgen-related protein)	3046	0.23
chr5_35803659_35803974	0.23	CTD-2113L7.1		23304	0.17
chr8_129297025_129297176	0.23	ENSG00000201782	.	64350	0.14
chr17_79603290_79603590	0.23	NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	646	0.5
chr7_144468170_144468428	0.23	TPK1	thiamin pyrophosphokinase 1	32284	0.22
chr8_42035186_42035337	0.22	AP3M2	adaptor-related protein complex 3, mu 2 subunit	10454	0.15
chr12_48593391_48593547	0.22	DKFZP779L1853		1299	0.34
chr14_106560956_106561107	0.22	IGHV2-10	immunoglobulin heavy variable 2-10 (pseudogene)	1056	0.2
chr12_28763600_28763751	0.22	CCDC91	coiled-coil domain containing 91	61678	0.15
chr3_23695229_23695380	0.22	ENSG00000212269	.	12221	0.23
chr12_10446475_10446699	0.22	KLRD1	killer cell lectin-like receptor subfamily D, member 1	10458	0.17
chr3_150423257_150423408	0.22	RP11-103G8.2		1502	0.31
chr6_35590292_35590577	0.22	ENSG00000212579	.	29161	0.14
chr2_119599709_119600100	0.22	EN1	engrailed homeobox 1	5350	0.31
chr2_120802121_120802311	0.22	EPB41L5	erythrocyte membrane protein band 4.1 like 5	25555	0.22
chr5_14811591_14811796	0.22	ENSG00000264792	.	14428	0.24
chr6_44890627_44890778	0.22	SUPT3H	suppressor of Ty 3 homolog (S. cerevisiae)	32545	0.25

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.2	GO:0002911	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.2	0.8	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.2	0.8	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.2	0.6	GO:0030223	neutrophil differentiation(GO:0030223)
0.2	0.6	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.1	GO:0002517	T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.1	0.6	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.5	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.3	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.1	0.2	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.1	0.3	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.3	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.1	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.1	0.2	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1	0.3	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.3	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.7	GO:0002837	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.1	0.3	GO:0000042	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1	0.3	GO:0048388	endosomal lumen acidification(GO:0048388)
0.1	0.3	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.6	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.3	GO:0002335	mature B cell differentiation(GO:0002335)
0.1	0.4	GO:0032876	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.1	0.3	GO:0002887	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.1	0.2	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.1	0.2	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	2.0	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.1	0.2	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.1	0.1	GO:0071922	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.1	0.5	GO:0043383	negative T cell selection(GO:0043383)
0.1	0.1	GO:0034393	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.1	0.2	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.1	0.2	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.1	0.2	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.1	0.2	GO:0006772	thiamine metabolic process(GO:0006772)
0.1	0.6	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.1	0.6	GO:0006491	N-glycan processing(GO:0006491)
0.1	0.5	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.1	0.2	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.1	0.2	GO:0045059	positive thymic T cell selection(GO:0045059)
0.1	0.2	GO:0010716	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1	0.1	GO:0019049	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.3	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1	0.3	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	0.2	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.1	0.3	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1	0.3	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.1	0.1	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.1	0.3	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.1	0.4	GO:0006198	cAMP catabolic process(GO:0006198)
0.1	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.1	0.5	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1	0.4	GO:0002063	chondrocyte development(GO:0002063)
0.1	0.3	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.1	0.1	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.1	0.4	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.1	0.2	GO:0006167	AMP biosynthetic process(GO:0006167)
0.1	0.1	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.1	0.3	GO:0042989	sequestering of actin monomers(GO:0042989)
0.1	0.2	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0033622	integrin activation(GO:0033622)
0.0	0.2	GO:0048617	embryonic foregut morphogenesis(GO:0048617)
0.0	0.2	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.2	GO:2000258	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.1	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.2	GO:0043045	DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0	0.1	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0007343	egg activation(GO:0007343)
0.0	0.4	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.2	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.1	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.1	GO:2000758	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.3	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.0	0.4	GO:0008105	asymmetric protein localization(GO:0008105)
0.0	0.1	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.2	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0045061	thymic T cell selection(GO:0045061)
0.0	0.0	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.4	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.1	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.2	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.2	GO:0032097	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.2	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.2	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.2	GO:0016556	mRNA modification(GO:0016556)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0032825	regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0	0.2	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.0	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.3	GO:0015074	DNA integration(GO:0015074)
0.0	0.1	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.2	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:2001021	negative regulation of response to DNA damage stimulus(GO:2001021)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:1904063	negative regulation of calcium ion import(GO:0090281) negative regulation of cation transmembrane transport(GO:1904063)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.2	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0002448	mast cell mediated immunity(GO:0002448)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.3	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.2	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.3	GO:0044409	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.1	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.5	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.3	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.1	GO:0002093	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.2	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0048548	regulation of pinocytosis(GO:0048548)
0.0	0.1	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.3	GO:0009086	methionine biosynthetic process(GO:0009086)
0.0	0.1	GO:0014034	neural crest formation(GO:0014029) neural crest cell fate commitment(GO:0014034)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.1	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.2	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.2	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0002724	regulation of T cell cytokine production(GO:0002724)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0	0.1	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0051461	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.0	GO:0046348	amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.1	GO:0003148	outflow tract septum morphogenesis(GO:0003148)
0.0	0.2	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.2	GO:0050901	leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0	0.4	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.2	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.1	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.1	GO:0050686	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.1	GO:0071801	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.0	GO:1901976	regulation of cell cycle checkpoint(GO:1901976)
0.0	0.1	GO:2001012	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0046477	glycosylceramide catabolic process(GO:0046477)
0.0	0.2	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.1	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein(GO:0042517)
0.0	0.2	GO:0043537	negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0	0.1	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.1	GO:0070265	necrotic cell death(GO:0070265)
0.0	0.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.0	0.0	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.1	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.1	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.1	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664)
0.0	0.3	GO:0043392	negative regulation of DNA binding(GO:0043392)
0.0	0.0	GO:0002888	positive regulation of myeloid leukocyte mediated immunity(GO:0002888)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.4	GO:0007030	Golgi organization(GO:0007030)
0.0	0.1	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.3	GO:0045576	mast cell activation(GO:0045576)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.0	GO:0098900	regulation of action potential(GO:0098900)
0.0	0.4	GO:0060330	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.1	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:0046666	retinal cell programmed cell death(GO:0046666)
0.0	0.0	GO:0014820	tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0	0.0	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
0.0	0.4	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.1	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.0	GO:0072141	mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0030910	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.0	GO:0045423	regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0	0.3	GO:0090278	negative regulation of peptide hormone secretion(GO:0090278)
0.0	0.1	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.9	GO:0031294	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.1	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.1	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0045579	positive regulation of B cell differentiation(GO:0045579)
0.0	0.2	GO:0046579	positive regulation of Ras protein signal transduction(GO:0046579)
0.0	0.0	GO:0048289	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0034331	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0	0.1	GO:0034695	response to prostaglandin E(GO:0034695)
0.0	0.0	GO:0060856	establishment of blood-brain barrier(GO:0060856)
0.0	0.2	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.1	GO:0048535	lymph node development(GO:0048535)
0.0	0.0	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0045540	regulation of cholesterol biosynthetic process(GO:0045540)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0060992	response to fungicide(GO:0060992)
0.0	0.0	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.2	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.1	GO:0045990	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0	0.1	GO:0032372	negative regulation of sterol transport(GO:0032372) negative regulation of cholesterol transport(GO:0032375)
0.0	0.1	GO:0032098	regulation of appetite(GO:0032098)
0.0	0.2	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0	0.1	GO:0034382	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0	0.1	GO:0010759	positive regulation of macrophage chemotaxis(GO:0010759)
0.0	0.1	GO:0002118	aggressive behavior(GO:0002118)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0031648	protein destabilization(GO:0031648)
0.0	0.1	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0071168	protein localization to chromatin(GO:0071168)
0.0	0.2	GO:0009268	response to pH(GO:0009268)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.0	GO:0071224	cellular response to peptidoglycan(GO:0071224)
0.0	0.8	GO:0006968	cellular defense response(GO:0006968)
0.0	0.2	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.0	GO:1902305	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.1	GO:0032410	negative regulation of transporter activity(GO:0032410)
0.0	0.0	GO:0009698	phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804)
0.0	0.0	GO:2000644	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.1	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein(GO:0042523)
0.0	0.1	GO:0034370	triglyceride-rich lipoprotein particle remodeling(GO:0034370) very-low-density lipoprotein particle remodeling(GO:0034372)
0.0	0.1	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.1	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.0	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0	0.0	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.0	GO:0042508	tyrosine phosphorylation of Stat1 protein(GO:0042508)
0.0	0.0	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.1	GO:0009812	flavonoid metabolic process(GO:0009812)
0.0	0.2	GO:0070534	protein K63-linked ubiquitination(GO:0070534)
0.0	0.0	GO:0014002	astrocyte development(GO:0014002)
0.0	0.0	GO:1900619	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.2	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.1	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.0	0.0	GO:0055015	ventricular cardiac muscle cell development(GO:0055015)
0.0	0.0	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.4	GO:0033572	ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0	0.1	GO:0040018	positive regulation of multicellular organism growth(GO:0040018)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0003085	negative regulation of systemic arterial blood pressure(GO:0003085)
0.0	0.0	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.0	GO:0033151	V(D)J recombination(GO:0033151)
0.0	0.1	GO:0021854	hypothalamus development(GO:0021854)
0.0	0.0	GO:0034384	high-density lipoprotein particle clearance(GO:0034384)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0048712	negative regulation of astrocyte differentiation(GO:0048712)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.0	GO:0032025	response to cobalt ion(GO:0032025)
0.0	0.2	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.0	GO:0032966	negative regulation of collagen biosynthetic process(GO:0032966)
0.0	0.0	GO:0051057	positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.0	0.0	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.0	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.0	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.0	0.0	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.0	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.2	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.0	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.1	GO:0048536	spleen development(GO:0048536)
0.0	0.0	GO:1903313	regulation of mRNA 3'-end processing(GO:0031440) positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.2	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.1	GO:0006265	DNA topological change(GO:0006265)
0.0	0.1	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.1	GO:0070897	RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0	0.1	GO:0034227	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.0	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.2	GO:0044036	cell wall macromolecule catabolic process(GO:0016998) cell wall macromolecule metabolic process(GO:0044036) cell wall organization or biogenesis(GO:0071554)
0.0	0.2	GO:0007052	mitotic spindle organization(GO:0007052)
0.0	0.0	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.1	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
0.0	0.2	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.0	0.0	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.0	GO:0032261	purine nucleotide salvage(GO:0032261)
0.0	0.0	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.0	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.0	GO:0045354	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0	0.0	GO:0048341	paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.0	0.0	GO:0032878	regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0	0.1	GO:0006390	mitochondrial RNA metabolic process(GO:0000959) transcription from mitochondrial promoter(GO:0006390)
0.0	0.1	GO:1904894	positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.0	0.1	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.0	GO:0072179	nephric duct formation(GO:0072179)
0.0	0.1	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.0	0.0	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.1	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.1	GO:0015824	proline transport(GO:0015824)
0.0	0.0	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.3	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.0	0.0	GO:0051154	negative regulation of striated muscle cell differentiation(GO:0051154)
0.0	0.0	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.0	GO:0048291	isotype switching to IgG isotypes(GO:0048291)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.0	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.2	GO:0030317	sperm motility(GO:0030317)
0.0	0.0	GO:0035092	sperm chromatin condensation(GO:0035092)
0.0	0.0	GO:0042161	plasma lipoprotein particle oxidation(GO:0034441) regulation of lipoprotein oxidation(GO:0034442) negative regulation of lipoprotein oxidation(GO:0034443) regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) lipoprotein modification(GO:0042160) lipoprotein oxidation(GO:0042161)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.1	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.0	GO:0021571	rhombomere 5 development(GO:0021571)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546)
0.0	0.0	GO:0019532	oxalate transport(GO:0019532)
0.0	0.0	GO:0015904	tetracycline transport(GO:0015904)
0.0	0.0	GO:0042435	indole-containing compound biosynthetic process(GO:0042435)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0046677	response to antibiotic(GO:0046677)
0.0	0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.0	GO:1901663	quinone biosynthetic process(GO:1901663)
0.0	0.0	GO:2001257	regulation of calcium ion transmembrane transporter activity(GO:1901019) regulation of cation channel activity(GO:2001257)
0.0	0.0	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.3	GO:0017157	regulation of exocytosis(GO:0017157)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.6	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.1	0.8	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.3	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.5	GO:0042589	zymogen granule membrane(GO:0042589)
0.1	0.2	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	0.3	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	0.2	GO:0001940	male pronucleus(GO:0001940)
0.1	0.2	GO:0001652	granular component(GO:0001652)
0.1	0.4	GO:0005606	laminin-1 complex(GO:0005606)
0.1	0.2	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.4	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.1	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.2	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.2	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.2	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.3	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.2	GO:0000791	euchromatin(GO:0000791)
0.0	0.2	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.2	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.3	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.2	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.2	GO:0045120	pronucleus(GO:0045120)
0.0	0.2	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.1	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.2	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.3	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.2	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.2	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.0	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.2	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	1.0	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.4	GO:0005844	polysome(GO:0005844)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.3	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	0.1	GO:0033162	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.3	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.1	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.6	GO:0043204	perikaryon(GO:0043204)
0.0	0.1	GO:0032838	cell projection cytoplasm(GO:0032838)
0.0	0.6	GO:0032587	ruffle membrane(GO:0032587)
0.0	0.0	GO:0071565	nBAF complex(GO:0071565)
0.0	0.4	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.2	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.2	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.2	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.5	GO:0030175	filopodium(GO:0030175)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.2	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.2	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.2	GO:0030288	outer membrane-bounded periplasmic space(GO:0030288) periplasmic space(GO:0042597)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	2.0	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	0.3	GO:0031256	leading edge membrane(GO:0031256)
0.0	0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.1	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0	0.2	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	0.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.2	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.5	GO:0005876	spindle microtubule(GO:0005876)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.2	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.1	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.0	GO:0000124	SAGA complex(GO:0000124)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0	0.2	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.2	GO:0071339	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0	0.1	GO:0005779	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	0.1	GO:0000346	transcription export complex(GO:0000346)
0.0	0.1	GO:0035267	NuA4 histone acetyltransferase complex(GO:0035267)
0.0	0.1	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.2	0.6	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.1	1.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.1	0.3	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.3	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.1	0.3	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.5	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.1	1.3	GO:0004697	protein kinase C activity(GO:0004697)
0.1	0.3	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.3	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.1	0.3	GO:0042608	T cell receptor binding(GO:0042608)
0.1	0.2	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1	0.2	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.1	0.7	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.1	0.2	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1	0.2	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.3	GO:0005131	growth hormone receptor binding(GO:0005131)
0.1	0.5	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	0.4	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.1	0.2	GO:0033691	sialic acid binding(GO:0033691)
0.1	0.3	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	0.3	GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1	0.2	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.1	0.2	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.1	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1	1.2	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.6	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	1.0	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.0	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.1	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.4	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0045159	myosin II binding(GO:0045159)
0.0	0.1	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.7	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.2	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.2	GO:0001637	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.7	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.5	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.7	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	1.5	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.1	GO:0070061	fructose binding(GO:0070061)
0.0	0.3	GO:0005522	profilin binding(GO:0005522)
0.0	0.6	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.9	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.2	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.3	GO:0030332	cyclin binding(GO:0030332)
0.0	1.2	GO:0101005	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.1	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.2	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.2	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.2	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.3	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.2	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.2	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.3	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.0	GO:0010861	thyroid hormone receptor activator activity(GO:0010861)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.3	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.2	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.3	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.0	0.3	GO:0035004	phosphatidylinositol 3-kinase activity(GO:0035004)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.0	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.2	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.2	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0	0.2	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.2	GO:0046625	sphingolipid binding(GO:0046625)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.3	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.0	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.2	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.3	GO:0016986	obsolete transcription initiation factor activity(GO:0016986)
0.0	0.2	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.1	GO:0015333	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.1	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.0	0.6	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.4	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.2	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.0	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:1990939	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.0	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.2	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.4	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.2	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.2	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.2	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.3	GO:0004190	aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0	1.6	GO:0017124	SH3 domain binding(GO:0017124)
0.0	0.1	GO:0000739	obsolete DNA strand annealing activity(GO:0000739)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.3	GO:0002039	p53 binding(GO:0002039)
0.0	0.1	GO:0004559	alpha-mannosidase activity(GO:0004559)
0.0	0.1	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.1	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0015278	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.1	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.2	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.0	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.2	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.0	0.0	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.0	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.1	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.0	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.0	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.3	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0	0.2	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.0	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.0	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.2	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.7	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.0	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.1	GO:0019534	toxin transporter activity(GO:0019534)
0.0	0.0	GO:0099528	G-protein coupled neurotransmitter receptor activity(GO:0099528)
0.0	0.0	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	0.4	GO:0003823	antigen binding(GO:0003823)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.0	GO:0015923	mannosidase activity(GO:0015923)
0.0	0.0	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.0	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.0	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.2	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	0.0	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.0	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.3	GO:0004629	phospholipase C activity(GO:0004629)
0.0	0.1	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.1	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.0	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.0	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.0	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.0	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.0	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.0	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.0	0.1	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.0	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.1	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.0	GO:0070643	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.2	GO:0050699	WW domain binding(GO:0050699)
0.0	0.0	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.2	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.0	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0005537	mannose binding(GO:0005537)
0.0	0.1	GO:0061630	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.4	GO:0019205	nucleobase-containing compound kinase activity(GO:0019205)
0.0	0.0	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.0	GO:0015215	nucleotide transmembrane transporter activity(GO:0015215)
0.0	0.0	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0	0.0	GO:0004064	arylesterase activity(GO:0004064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.6	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	0.6	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	1.0	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	2.6	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	0.7	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	1.5	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	0.5	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	1.1	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	1.0	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	1.3	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.5	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	0.3	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.4	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.6	PID MYC PATHWAY	C-MYC pathway
0.0	0.3	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.4	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.2	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.1	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.5	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.2	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.6	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.6	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.2	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	0.0	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	0.2	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.4	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.2	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.1	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	0.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.2	PID REELIN PATHWAY	Reelin signaling pathway
0.0	0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.3	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.0	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.2	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.2	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.1	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	0.0	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.5	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	0.3	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	1.3	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.4	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	1.0	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	1.6	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	1.5	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1	0.4	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1	0.7	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.6	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.5	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	1.3	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.3	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.8	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.5	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.6	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.3	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.9	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.0	1.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.2	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.4	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.0	0.0	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.2	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.2	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.2	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.2	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.3	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.4	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.2	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.0	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	0.4	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.2	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.3	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.2	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.0	0.0	REACTOME P75NTR SIGNALS VIA NFKB	Genes involved in p75NTR signals via NF-kB
0.0	0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.1	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.0	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.0	0.2	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.0	0.3	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.0	0.0	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	0.3	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.1	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.0	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.3	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.3	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.3	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.0	0.0	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.0	0.2	REACTOME PKB MEDIATED EVENTS	Genes involved in PKB-mediated events
0.0	0.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway

Results for IRF7

Z-value: 1.74

Motif logo

Transcription factors associated with IRF7

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the IRF7 motif across conditions

Conditions sorted by the z-value of the IRF7 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: