CREMA results: IRF9

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Transcription factors associated with IRF9

Gene Symbol	Gene ID	Gene Info
IRF9 Ensembl NCBI GeneCards UniProt	ENSG00000213928.4	interferon regulatory factor 9

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr14_24629657_24629808	IRF9	530	0.453805	0.64	6.2e-02	Click!
chr14_24630607_24630758	IRF9	172	0.827781	-0.51	1.7e-01	Click!
chr14_24631008_24631282	IRF9	635	0.391531	-0.65	5.6e-02	Click!
chr14_24632118_24632685	IRF9	196	0.808671	0.72	2.7e-02	Click!
chr14_24633422_24633618	IRF9	1315	0.168660	0.62	7.4e-02	Click!

Showing 1 to 5 of 5 entries

Activity of the IRF9 motif across conditions

Conditions sorted by the z-value of the IRF9 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr16_28308673_28308825	0.61	SBK1	SH3 domain binding kinase 1	4909	0.23
chr6_5984279_5984492	0.56	NRN1	neuritin 1	22815	0.22
chr5_110585847_110586110	0.49	AC010468.2		19809	0.19
chr3_53380740_53380960	0.44	DCP1A	decapping mRNA 1A	702	0.63
chr12_12679407_12679558	0.41	DUSP16	dual specificity phosphatase 16	5423	0.27
chr4_123134100_123134251	0.39	KIAA1109	KIAA1109	6449	0.31
chr21_34561335_34561486	0.38	C21orf54	chromosome 21 open reading frame 54	18869	0.14
chr16_10946685_10946855	0.38	CIITA	class II, major histocompatibility complex, transactivator	24285	0.14
chr7_37354921_37355641	0.36	ELMO1	engulfment and cell motility 1	27086	0.19
chr2_202137440_202137733	0.36	CASP8	caspase 8, apoptosis-related cysteine peptidase	225	0.94

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.3	GO:0006611	protein export from nucleus(GO:0006611)
0.1	0.2	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.2	GO:0000266	mitochondrial fission(GO:0000266)
0.0	0.2	GO:0010324	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)

Showing 1 to 10 of 51 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.3	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.2	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.2	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.1	GO:0001740	Barr body(GO:0001740)

Showing 1 to 10 of 16 entries

Gene overrepresentation in molecular function category:

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Total log-likelihood	Term	Description
0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.1	GO:0033691	sialic acid binding(GO:0033691)
0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.1	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)

Showing 1 to 10 of 28 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	ST G ALPHA S PATHWAY	G alpha s Pathway

Showing 1 to 3 of 3 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.4	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.1	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells

Showing 1 to 10 of 12 entries

Results for IRF9

Z-value: 0.97

Motif logo

Transcription factors associated with IRF9

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the IRF9 motif across conditions

Conditions sorted by the z-value of the IRF9 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: