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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for IRX2

Z-value: 2.53

Motif logo

Transcription factors associated with IRX2

Gene Symbol	Gene ID	Gene Info
IRX2 Ensembl NCBI GeneCards UniProt	ENSG00000170561.8	IRX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
IRX2	chr5_2739330_2739481	12364	0.244694	-0.77	1.5e-02	Click!
IRX2	chr5_2739627_2739778	12067	0.245219	-0.44	2.4e-01	Click!
IRX2	chr5_2750173_2750324	1521	0.412772	0.29	4.6e-01	Click!

Activity of the IRX2 motif across conditions

Conditions sorted by the z-value of the IRX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_106383531_106383975	0.59	NCK2	NCK adaptor protein 2	21565	0.26
chr3_154867378_154867529	0.53	MME-AS1	MME antisense RNA 1	33621	0.22
chr4_25845411_25845804	0.52	SEL1L3	sel-1 suppressor of lin-12-like 3 (C. elegans)	16646	0.24
chr16_67718722_67719015	0.51	C16orf86	chromosome 16 open reading frame 86	18075	0.09
chr5_168842640_168842791	0.48	SLIT3	slit homolog 3 (Drosophila)	114582	0.06
chr2_36757574_36758239	0.44	RP11-78I14.1		17031	0.17
chr21_36330048_36330210	0.43	RUNX1	runt-related transcription factor 1	68042	0.14
chr8_108684494_108684645	0.42	ANGPT1	angiopoietin 1	174286	0.03
chr6_169890374_169890525	0.41	WDR27	WD repeat domain 27	170339	0.03
chr12_14539508_14539659	0.41	ATF7IP	activating transcription factor 7 interacting protein	1585	0.47
chr19_16478953_16479699	0.41	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	6562	0.16
chr1_52076976_52077127	0.40	OSBPL9	oxysterol binding protein-like 9	5496	0.23
chr5_55498484_55498698	0.39	ANKRD55	ankyrin repeat domain 55	30162	0.16
chr3_16889716_16889867	0.39	PLCL2	phospholipase C-like 2	36661	0.2
chr2_223434159_223434310	0.39	RP11-16P6.1		204	0.96
chr20_48203946_48204097	0.39	ENSG00000265225	.	803	0.67
chr20_2820395_2820814	0.38	PCED1A	PC-esterase domain containing 1A	713	0.38
chr13_99933650_99933945	0.37	GPR18	G protein-coupled receptor 18	19799	0.17
chr1_220950327_220950478	0.37	MARC1	mitochondrial amidoxime reducing component 1	9699	0.19
chr6_135040752_135041042	0.36	ALDH8A1	aldehyde dehydrogenase 8 family, member A1	209402	0.02
chr2_46665689_46665843	0.36	ENSG00000241791	.	9884	0.2
chr2_198127644_198128365	0.36	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	39239	0.13
chr7_47705936_47706228	0.36	C7orf65	chromosome 7 open reading frame 65	11240	0.26
chr7_7712444_7712595	0.36	RPA3	replication protein A3, 14kDa	31916	0.21
chr12_81326738_81326889	0.35	ENSG00000208022	.	2799	0.24
chr1_15480447_15481131	0.35	TMEM51	transmembrane protein 51	504	0.82
chr4_86757167_86757466	0.35	ARHGAP24	Rho GTPase activating protein 24	8270	0.28
chr10_95274846_95275177	0.35	ENSG00000212396	.	4574	0.19
chr1_114324657_114324917	0.34	PHTF1	putative homeodomain transcription factor 1	22689	0.15
chr2_162807979_162808245	0.34	ENSG00000253046	.	32820	0.21
chr2_145253384_145253620	0.34	ZEB2	zinc finger E-box binding homeobox 2	21613	0.22
chr13_45895503_45895692	0.34	ENSG00000253051	.	14985	0.11
chr4_111096983_111097134	0.34	ELOVL6	ELOVL fatty acid elongase 6	22751	0.22
chr7_100397045_100397346	0.33	ENSG00000263672	.	21691	0.1
chr6_107645107_107645353	0.33	PDSS2	prenyl (decaprenyl) diphosphate synthase, subunit 2	111867	0.06
chr6_122329889_122330040	0.33	ENSG00000199932	.	202830	0.03
chr1_78721233_78721384	0.33	ENSG00000237413	.	26002	0.2
chr15_99489885_99490412	0.33	IGF1R	insulin-like growth factor 1 receptor	22319	0.19
chr9_123200598_123200791	0.33	CDK5RAP2	CDK5 regulatory subunit associated protein 2	9656	0.31
chr4_86727557_86727760	0.33	ARHGAP24	Rho GTPase activating protein 24	21240	0.24
chr3_153345455_153345756	0.32	ENSG00000200162	.	20439	0.26
chr10_7088660_7089557	0.32	SFMBT2	Scm-like with four mbt domains 2	361599	0.01
chr4_86595083_86595234	0.32	ENSG00000266421	.	48463	0.17
chr2_198123616_198124373	0.32	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	43249	0.13
chr2_63890050_63890201	0.32	ENSG00000221085	.	32544	0.2
chr9_77762259_77762961	0.32	ENSG00000200041	.	33927	0.15
chr11_118097693_118098499	0.31	AMICA1	adhesion molecule, interacts with CXADR antigen 1	2287	0.23
chr1_110415768_110416011	0.31	RP11-195M16.1		12997	0.17
chr1_9739584_9739800	0.31	RP11-558F24.4		7921	0.18
chr1_65387999_65388150	0.31	JAK1	Janus kinase 1	44113	0.17
chr8_8718009_8718517	0.31	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	32892	0.17
chr8_59492254_59492405	0.31	SDCBP	syndecan binding protein (syntenin)	14754	0.24
chr2_68597035_68597533	0.31	AC015969.3		4568	0.19
chr2_55518720_55518871	0.31	ENSG00000206964	.	5641	0.15
chr9_221181_221359	0.31	C9orf66	chromosome 9 open reading frame 66	5377	0.19
chr3_131563587_131563738	0.30	CPNE4	copine IV	80763	0.11
chr19_7733657_7733953	0.30	RETN	resistin	125	0.91
chr11_33302196_33302347	0.30	HIPK3	homeodomain interacting protein kinase 3	22394	0.2
chr10_6322222_6322373	0.30	ENSG00000238366	.	34503	0.15
chr3_108021242_108021538	0.30	HHLA2	HERV-H LTR-associating 2	58	0.98
chr1_33723200_33724119	0.30	ZNF362	zinc finger protein 362	1485	0.38
chr10_102669234_102669601	0.30	ENSG00000222072	.	2380	0.18
chr21_39190684_39190863	0.30	KCNJ6	potassium inwardly-rectifying channel, subfamily J, member 6	94784	0.08
chr5_111304224_111304663	0.29	NREP-AS1	NREP antisense RNA 1	706	0.74
chr2_98343204_98343355	0.29	ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	1946	0.32
chr6_87910032_87910183	0.29	ZNF292	zinc finger protein 292	33135	0.16
chr15_80271357_80271985	0.29	BCL2A1	BCL2-related protein A1	7883	0.2
chr7_151122661_151122812	0.29	RP4-555L14.4		2033	0.2
chr3_113831548_113831699	0.29	QTRTD1	queuine tRNA-ribosyltransferase domain containing 1	30007	0.17
chr12_78398855_78399006	0.29	NAV3	neuron navigator 3	38874	0.22
chr16_73200279_73201088	0.29	C16orf47	chromosome 16 open reading frame 47	22337	0.26
chr5_75395327_75395609	0.29	ENSG00000252833	.	7842	0.25
chr4_78003999_78004150	0.29	CCNI	cyclin I	6916	0.24
chr3_140938122_140938273	0.29	ACPL2	acid phosphatase-like 2	9371	0.27
chr10_97552518_97552961	0.29	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	37025	0.15
chr11_43772662_43772813	0.28	HSD17B12	hydroxysteroid (17-beta) dehydrogenase 12	70406	0.1
chr8_134541719_134541989	0.28	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	30228	0.24
chr2_54657078_54657582	0.28	SPTBN1	spectrin, beta, non-erythrocytic 1	26092	0.22
chr8_128836786_128836937	0.28	ENSG00000249859	.	28653	0.21
chr2_145137951_145138102	0.28	GTDC1	glycosyltransferase-like domain containing 1	47943	0.16
chr2_136689063_136689371	0.28	DARS	aspartyl-tRNA synthetase	11094	0.21
chr2_42473364_42473515	0.28	EML4	echinoderm microtubule associated protein like 4	54954	0.14
chr2_228356582_228356746	0.28	AGFG1	ArfGAP with FG repeats 1	16324	0.2
chr9_138981710_138981861	0.28	NACC2	NACC family member 2, BEN and BTB (POZ) domain containing	5346	0.22
chr15_39626996_39627182	0.28	RP11-624L4.1		61005	0.14
chr2_161442081_161442232	0.28	RBMS1	RNA binding motif, single stranded interacting protein 1	91851	0.09
chr4_153466291_153466442	0.28	ENSG00000268471	.	8786	0.2
chr11_108102757_108102978	0.28	ENSG00000206967	.	2536	0.23
chr12_70376087_70376238	0.28	RP11-611E13.3		35301	0.19
chr2_28352746_28352897	0.28	ENSG00000265321	.	133587	0.05
chr13_50795355_50795506	0.28	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	139123	0.04
chr3_12509546_12509697	0.28	TSEN2	TSEN2 tRNA splicing endonuclease subunit	16310	0.16
chr1_221488124_221488275	0.28	DUSP10	dual specificity phosphatase 10	422603	0.01
chr15_78361706_78361921	0.28	TBC1D2B	TBC1 domain family, member 2B	3348	0.17
chr1_185298763_185298914	0.27	IVNS1ABP	influenza virus NS1A binding protein	12377	0.22
chr6_24979166_24979784	0.27	FAM65B	family with sequence similarity 65, member B	43287	0.14
chr7_27964371_27964522	0.27	ENSG00000265382	.	44340	0.16
chr2_32296061_32296212	0.27	SPAST	spastin	7360	0.17
chr1_66839472_66840219	0.27	PDE4B	phosphodiesterase 4B, cAMP-specific	19780	0.27
chr10_64379208_64379359	0.27	ZNF365	zinc finger protein 365	24250	0.22
chr1_231015041_231015192	0.27	RP5-858B6.3		4524	0.14
chr10_11336975_11337126	0.27	CELF2-AS1	CELF2 antisense RNA 1	24797	0.24
chr9_117768493_117768791	0.27	TNC	tenascin C	58549	0.14
chr15_82496446_82496597	0.27	ENSG00000212170	.	29795	0.15
chr4_85836939_85837233	0.27	ENSG00000252062	.	29447	0.21
chr3_152215781_152215932	0.27	RP11-362A9.3		1254	0.56
chr8_121760612_121760811	0.27	RP11-713M15.1		12782	0.25
chr2_113944482_113944729	0.27	PSD4	pleckstrin and Sec7 domain containing 4	9252	0.14
chr7_127998275_127998426	0.27	PRRT4	proline-rich transmembrane protein 4	1339	0.36
chr21_36346755_36347126	0.27	RUNX1	runt-related transcription factor 1	74522	0.13
chr15_86123833_86124949	0.27	RP11-815J21.2		982	0.53
chr6_109201302_109201453	0.27	ARMC2	armadillo repeat containing 2	11196	0.24
chr12_22383122_22383273	0.27	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	18783	0.23
chr2_38798588_38798739	0.27	HNRNPLL	heterogeneous nuclear ribonucleoprotein L-like	1685	0.41
chr6_14700888_14701039	0.27	ENSG00000206960	.	54197	0.18
chr9_75775412_75775563	0.27	ANXA1	annexin A1	2917	0.38
chr11_59016128_59016425	0.26	ENSG00000263999	.	34104	0.13
chr3_182428407_182428558	0.26	RP11-225N10.1		82700	0.1
chr20_47629406_47629557	0.26	RP1-155G6.4		33100	0.17
chr1_92017582_92017733	0.26	CDC7	cell division cycle 7	50962	0.18
chr7_155515211_155515362	0.26	RBM33	RNA binding motif protein 33	21701	0.22
chr10_112651307_112651546	0.26	ENSG00000265827	.	6422	0.14
chr15_39866169_39866433	0.26	THBS1	thrombospondin 1	6979	0.21
chr10_104890869_104891020	0.26	NT5C2	5'-nucleotidase, cytosolic II	22440	0.21
chr8_67055451_67055668	0.26	TRIM55	tripartite motif containing 55	16281	0.23
chr22_22209971_22210122	0.26	MAPK1	mitogen-activated protein kinase 1	11684	0.15
chr2_23927928_23928079	0.26	KLHL29	kelch-like family member 29	62741	0.13
chr1_21385882_21386033	0.26	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	8470	0.26
chr6_139836821_139836972	0.26	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	141139	0.05
chrX_109200589_109200740	0.26	TMEM164	transmembrane protein 164	45199	0.18
chr2_237858362_237858513	0.26	ENSG00000202341	.	65511	0.12
chr8_61925125_61925700	0.26	CLVS1	clavesin 1	44305	0.2
chr6_109560238_109560680	0.26	ENSG00000238474	.	52102	0.12
chr1_20902306_20902457	0.26	CDA	cytidine deaminase	13060	0.17
chr8_134562977_134563358	0.26	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	20925	0.27
chr5_168553589_168553740	0.26	CTB-174D11.1		96221	0.08
chr6_138027696_138027847	0.26	ENSG00000216097	.	10314	0.27
chr17_61502956_61503238	0.26	RP11-269G24.3		5353	0.14
chr2_225850813_225850964	0.26	ENSG00000263828	.	24369	0.23
chr5_101618511_101618782	0.26	SLCO4C1	solute carrier organic anion transporter family, member 4C1	13607	0.2
chr6_16404477_16404628	0.26	ENSG00000265642	.	24202	0.26
chr1_35920565_35920716	0.26	KIAA0319L	KIAA0319-like	332	0.89
chr5_148801935_148802347	0.26	ENSG00000208035	.	6340	0.15
chr3_112456089_112456520	0.26	ENSG00000242770	.	65021	0.11
chr5_8727783_8727934	0.26	ENSG00000247516	.	266820	0.02
chr12_82337130_82337312	0.26	PPFIA2	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	183889	0.03
chr7_138604637_138604804	0.26	KIAA1549	KIAA1549	499	0.84
chr17_79483461_79484043	0.26	ACTG1	actin, gamma 1	2086	0.16
chr7_125726_125877	0.26	FAM20C	family with sequence similarity 20, member C	67168	0.12
chr6_45452002_45452153	0.25	RUNX2	runt-related transcription factor 2	61855	0.13
chr2_128406747_128407440	0.25	GPR17	G protein-coupled receptor 17	421	0.7
chr15_68499988_68500218	0.25	CALML4	calmodulin-like 4	1686	0.33
chr6_111025543_111025694	0.25	ENSG00000200522	.	17933	0.22
chr20_35570220_35570403	0.25	SAMHD1	SAM domain and HD domain 1	9800	0.21
chr12_13154703_13155247	0.25	HEBP1	heme binding protein 1	1768	0.27
chr20_58807824_58807975	0.25	ENSG00000207802	.	75633	0.12
chr11_19130331_19130482	0.25	ZDHHC13	zinc finger, DHHC-type containing 13	8270	0.22
chr3_81802908_81803078	0.25	GBE1	glucan (1,4-alpha-), branching enzyme 1	8319	0.34
chr1_29388426_29388715	0.25	TMEM200B	transmembrane protein 200B	60443	0.1
chr7_114857333_114857484	0.25	ENSG00000199764	.	9358	0.33
chr16_4050021_4050172	0.25	ADCY9	adenylate cyclase 9	11095	0.18
chr3_151916865_151917016	0.25	MBNL1	muscleblind-like splicing regulator 1	68889	0.12
chr4_153392019_153392170	0.25	ENSG00000264678	.	18474	0.21
chr7_106063817_106063968	0.25	CTB-111H14.1		81393	0.1
chr10_3816114_3816265	0.25	RP11-184A2.2		6082	0.22
chr6_10413127_10413925	0.25	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	414	0.77
chr3_72060973_72061124	0.25	ENSG00000239250	.	184720	0.03
chr2_204303722_204303873	0.25	ABI2	abl-interactor 2	48030	0.15
chr19_41332938_41333153	0.25	EGLN2	egl-9 family hypoxia-inducible factor 2	19897	0.11
chr2_190017847_190017998	0.25	ENSG00000264725	.	20085	0.19
chr11_70261652_70262194	0.24	CTTN	cortactin	4308	0.17
chr1_236006258_236006409	0.24	LYST-AS1	LYST antisense RNA 1	3550	0.2
chr2_143922793_143923037	0.24	RP11-190J23.1		6826	0.27
chr10_73514684_73515259	0.24	C10orf54	chromosome 10 open reading frame 54	2416	0.29
chr14_35152571_35152722	0.24	ENSG00000253003	.	7549	0.2
chr1_203158968_203159119	0.24	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	3166	0.19
chr3_187605321_187605472	0.24	BCL6	B-cell CLL/lymphoma 6	141881	0.05
chr11_13358056_13358317	0.24	ENSG00000222162	.	16569	0.22
chr16_81531821_81532117	0.24	CMIP	c-Maf inducing protein	3015	0.36
chr15_86245685_86246263	0.24	RP11-815J21.1		1634	0.25
chr1_200337779_200337983	0.24	ZNF281	zinc finger protein 281	41239	0.21
chr12_80295001_80295152	0.24	PPP1R12A	protein phosphatase 1, regulatory subunit 12A	12615	0.18
chr5_49850280_49850431	0.24	PARP8	poly (ADP-ribose) polymerase family, member 8	111378	0.07
chrX_77194022_77194173	0.24	ATP7A	ATPase, Cu++ transporting, alpha polypeptide	27898	0.14
chr2_98171418_98171569	0.24	ANKRD36B	ankyrin repeat domain 36B	10353	0.2
chrX_13096464_13097003	0.24	FAM9C	family with sequence similarity 9, member C	33932	0.21
chr6_97667926_97668077	0.24	MMS22L	MMS22-like, DNA repair protein	43227	0.21
chr7_37026279_37026430	0.24	ELMO1	engulfment and cell motility 1	240	0.94
chr11_47276308_47276801	0.24	NR1H3	nuclear receptor subfamily 1, group H, member 3	2601	0.15
chr2_136734580_136734731	0.24	AC093391.2		8091	0.21
chr20_40110976_40111127	0.24	CHD6	chromodomain helicase DNA binding protein 6	16906	0.25
chr5_171325858_171326009	0.24	FBXW11	F-box and WD repeat domain containing 11	78827	0.09
chr17_65516947_65517209	0.24	CTD-2653B5.1		3519	0.24
chr5_129906760_129906911	0.24	ENSG00000252514	.	184462	0.03
chr9_117094142_117094333	0.24	ORM2	orosomucoid 2	2085	0.3
chr3_105626614_105626964	0.24	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	38393	0.24
chr11_67973501_67973746	0.24	SUV420H1	suppressor of variegation 4-20 homolog 1 (Drosophila)	6598	0.21
chr12_32676345_32676560	0.24	FGD4	FYVE, RhoGEF and PH domain containing 4	10806	0.25
chr7_76823195_76823489	0.24	FGL2	fibrinogen-like 2	5801	0.24
chr7_82305530_82305681	0.24	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	232491	0.02

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.4	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.3	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.3	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.1	0.3	GO:0070672	response to interleukin-15(GO:0070672)
0.1	0.2	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.3	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1	0.5	GO:0006198	cAMP catabolic process(GO:0006198)
0.1	0.3	GO:0031297	replication fork processing(GO:0031297)
0.1	0.3	GO:0002667	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.1	0.2	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.1	0.2	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.1	0.2	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.1	0.2	GO:0043116	negative regulation of vascular permeability(GO:0043116)
0.1	0.1	GO:0002666	T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.1	0.3	GO:0045059	positive thymic T cell selection(GO:0045059)
0.1	0.3	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.1	0.3	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.1	0.2	GO:0007132	meiotic metaphase I(GO:0007132)
0.1	0.2	GO:0015825	L-serine transport(GO:0015825)
0.1	0.2	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0	0.2	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.2	GO:0001779	natural killer cell differentiation(GO:0001779)
0.0	0.5	GO:0010324	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.4	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.2	GO:0033261	obsolete regulation of S phase(GO:0033261)
0.0	0.1	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.0	0.0	GO:0048478	replication fork protection(GO:0048478)
0.0	0.1	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.2	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.2	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.4	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.0	0.1	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.2	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.2	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.1	GO:0060058	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.2	GO:0032876	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.6	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.1	GO:0034776	response to histamine(GO:0034776)
0.0	0.2	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.2	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0042663	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0052556	positive regulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052555) positive regulation by symbiont of host immune response(GO:0052556)
0.0	0.0	GO:0021873	forebrain neuroblast division(GO:0021873)
0.0	0.1	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.0	GO:0010536	regulation of activation of Janus kinase activity(GO:0010533) positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	0.2	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0009158	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.1	GO:0034505	tooth mineralization(GO:0034505)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.1	GO:0035929	steroid hormone secretion(GO:0035929) corticosteroid hormone secretion(GO:0035930) regulation of steroid hormone secretion(GO:2000831) regulation of corticosteroid hormone secretion(GO:2000846)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0	0.1	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0	0.1	GO:0036315	cellular response to sterol(GO:0036315) cellular response to cholesterol(GO:0071397)
0.0	0.1	GO:0002544	chronic inflammatory response(GO:0002544)
0.0	0.1	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0032353	negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0	0.1	GO:2000188	regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0051459	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.2	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.1	GO:0021831	embryonic olfactory bulb interneuron precursor migration(GO:0021831)
0.0	0.1	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.1	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.4	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.1	GO:0010940	positive regulation of necrotic cell death(GO:0010940)
0.0	0.4	GO:0090659	adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0035307	positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.0	0.0	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.0	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.1	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.1	GO:0001787	natural killer cell proliferation(GO:0001787)
0.0	0.3	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.1	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.1	GO:0042117	monocyte activation(GO:0042117)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.2	GO:0061756	leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0	0.4	GO:0032011	ARF protein signal transduction(GO:0032011)
0.0	0.1	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.3	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.1	GO:0031033	myosin filament organization(GO:0031033)
0.0	0.0	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.1	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.2	GO:0046133	pyrimidine ribonucleoside catabolic process(GO:0046133)
0.0	0.2	GO:0042438	melanin biosynthetic process(GO:0042438)
0.0	0.0	GO:0010566	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.0	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0033005	positive regulation of mast cell activation(GO:0033005)
0.0	0.2	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0015911	plasma membrane long-chain fatty acid transport(GO:0015911)
0.0	0.1	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.0	GO:0001878	response to yeast(GO:0001878)
0.0	0.0	GO:0009214	cyclic nucleotide catabolic process(GO:0009214)
0.0	0.2	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.1	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.0	GO:0017014	protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.5	GO:0060338	regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0	0.1	GO:0002092	positive regulation of receptor internalization(GO:0002092)
0.0	0.0	GO:0002016	regulation of blood volume by renin-angiotensin(GO:0002016)
0.0	0.1	GO:0006895	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.1	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.1	GO:0042977	activation of JAK2 kinase activity(GO:0042977)
0.0	0.0	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.1	GO:0097435	extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0	0.0	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.0	0.1	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.1	GO:0032025	response to cobalt ion(GO:0032025)
0.0	0.0	GO:0042253	granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253) regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0	0.2	GO:0010874	regulation of cholesterol efflux(GO:0010874)
0.0	0.1	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.1	GO:0097531	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.0	GO:0043173	nucleotide salvage(GO:0043173)
0.0	0.1	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.0	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.0	0.1	GO:0051647	establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.0	GO:0048711	positive regulation of astrocyte differentiation(GO:0048711)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.3	GO:0050832	defense response to fungus(GO:0050832)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0046325	negative regulation of glucose import(GO:0046325)
0.0	0.1	GO:0001885	endothelial cell development(GO:0001885)
0.0	0.0	GO:0009174	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.0	GO:0031427	response to methotrexate(GO:0031427)
0.0	0.0	GO:0060197	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.0	GO:0033084	regulation of immature T cell proliferation in thymus(GO:0033084)
0.0	0.2	GO:0030260	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.2	GO:0006195	purine nucleotide catabolic process(GO:0006195)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.0	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis(GO:0060664)
0.0	0.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.0	GO:0019530	taurine metabolic process(GO:0019530)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.0	GO:0045915	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0	0.1	GO:0018202	peptidyl-histidine modification(GO:0018202)
0.0	0.0	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.1	GO:0048892	sensory system development(GO:0048880) lateral line nerve development(GO:0048892) lateral line nerve glial cell differentiation(GO:0048895) lateral line system development(GO:0048925) lateral line nerve glial cell development(GO:0048937) iridophore differentiation(GO:0050935)
0.0	0.0	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.1	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.0	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.0	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.0	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.0	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.0	GO:0016999	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.0	GO:0032785	negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0	0.0	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0032782	canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.0	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0042772	DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.0	0.0	GO:0044273	sulfur amino acid catabolic process(GO:0000098) sulfur compound catabolic process(GO:0044273)
0.0	0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.0	GO:0043570	maintenance of DNA repeat elements(GO:0043570)
0.0	0.1	GO:0048679	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934)
0.0	0.1	GO:0001556	oocyte maturation(GO:0001556)
0.0	0.1	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.0	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.1	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.1	GO:0050764	regulation of phagocytosis(GO:0050764) positive regulation of phagocytosis(GO:0050766)
0.0	0.2	GO:0046579	positive regulation of Ras protein signal transduction(GO:0046579)
0.0	0.1	GO:0009136	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.1	GO:0033687	osteoblast proliferation(GO:0033687)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.0	GO:0009414	response to water deprivation(GO:0009414) response to water(GO:0009415)
0.0	0.0	GO:2000258	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.0	GO:0033085	negative regulation of T cell differentiation in thymus(GO:0033085) negative regulation of thymocyte aggregation(GO:2000399)
0.0	0.0	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.1	GO:0021955	central nervous system projection neuron axonogenesis(GO:0021952) central nervous system neuron axonogenesis(GO:0021955)
0.0	0.3	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.0	GO:0071803	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.1	GO:0032770	positive regulation of monooxygenase activity(GO:0032770)
0.0	0.0	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0014041	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.0	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0046189	phenol-containing compound biosynthetic process(GO:0046189)
0.0	0.0	GO:0072205	metanephric collecting duct development(GO:0072205)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.0	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.1	GO:0016056	rhodopsin mediated signaling pathway(GO:0016056)
0.0	0.0	GO:0048485	sympathetic nervous system development(GO:0048485)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.1	GO:0098764	meiosis I cell cycle phase(GO:0098764)
0.0	0.1	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.0	GO:0048840	otolith development(GO:0048840)
0.0	0.0	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.1	GO:0001938	positive regulation of endothelial cell proliferation(GO:0001938)
0.0	0.1	GO:0006388	RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.0	GO:0001757	somite specification(GO:0001757)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.0	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.0	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.0	GO:0032802	low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0	0.0	GO:0048148	behavioral response to cocaine(GO:0048148)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	0.2	GO:0033268	node of Ranvier(GO:0033268)
0.1	0.2	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	0.3	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.4	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.2	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.2	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.2	GO:0045179	apical cortex(GO:0045179)
0.0	0.2	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.0	0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.1	GO:0071547	piP-body(GO:0071547)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.1	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.2	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.4	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.2	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.1	GO:0000805	X chromosome(GO:0000805)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.2	GO:0042555	MCM complex(GO:0042555)
0.0	0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.2	GO:0034464	BBSome(GO:0034464)
0.0	0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.2	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.1	GO:0030893	meiotic cohesin complex(GO:0030893)
0.0	0.2	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.2	GO:0042581	specific granule(GO:0042581)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.2	GO:0071203	WASH complex(GO:0071203)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.3	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.1	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.1	GO:0070083	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.1	GO:0030312	external encapsulating structure(GO:0030312)
0.0	0.0	GO:0032009	early phagosome(GO:0032009)
0.0	0.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.0	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.0	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.0	GO:0008537	proteasome activator complex(GO:0008537)
0.0	0.0	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.0	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.2	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.1	GO:0042627	chylomicron(GO:0042627)
0.0	0.0	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.0	GO:0071986	Ragulator complex(GO:0071986)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1	0.4	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.4	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.1	0.3	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.2	GO:0035184	histone threonine kinase activity(GO:0035184)
0.1	0.5	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.1	0.2	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.1	0.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.2	GO:0004340	glucokinase activity(GO:0004340)
0.1	0.3	GO:0004046	aminoacylase activity(GO:0004046)
0.1	0.2	GO:0070097	delta-catenin binding(GO:0070097)
0.1	0.2	GO:0034584	piRNA binding(GO:0034584)
0.1	0.2	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1	0.2	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.2	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.7	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.2	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.2	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.2	GO:0060229	lipase activator activity(GO:0060229)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.7	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.7	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.1	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.3	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0015333	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0032296	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.1	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.3	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.2	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0008061	chitin binding(GO:0008061)
0.0	0.1	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.2	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.5	GO:0015459	potassium channel regulator activity(GO:0015459)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.2	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.3	GO:0001637	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.0	GO:0004952	dopamine neurotransmitter receptor activity(GO:0004952)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.0	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.2	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0004500	dopamine beta-monooxygenase activity(GO:0004500)
0.0	0.2	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.1	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.1	GO:0030354	melanin-concentrating hormone activity(GO:0030354)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.0	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.0	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.2	GO:0005451	monovalent cation:proton antiporter activity(GO:0005451)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.0	GO:0004802	transketolase activity(GO:0004802)
0.0	0.0	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.1	GO:0004339	glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.0	0.1	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.1	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.1	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.1	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.0	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	0.0	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.0	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.1	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.0	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.3	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.2	GO:1905030	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.1	GO:0030553	cGMP binding(GO:0030553)
0.0	0.0	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.2	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.0	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.4	GO:0005518	collagen binding(GO:0005518)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.0	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0015211	purine nucleoside transmembrane transporter activity(GO:0015211)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.0	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.0	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.0	GO:0004476	mannose-6-phosphate isomerase activity(GO:0004476)
0.0	0.1	GO:0031210	phosphatidylcholine binding(GO:0031210)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.0	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0	0.0	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.2	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.0	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.2	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.0	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.0	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.2	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.1	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	0.0	GO:0004083	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) bisphosphoglycerate phosphatase activity(GO:0034416)
0.0	0.1	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.0	GO:0099589	G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.0	0.0	GO:0031014	troponin T binding(GO:0031014)
0.0	0.0	GO:0008545	JUN kinase kinase activity(GO:0008545)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.7	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4	PID IL5 PATHWAY	IL5-mediated signaling events
1.2	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.5	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.6	PID ARF 3PATHWAY	Arf1 pathway
0.5	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.3	PID IL3 PATHWAY	IL3-mediated signaling events
0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.2	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.3	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.1	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.6	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.1	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.2	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.0	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	PID S1P S1P3 PATHWAY	S1P3 pathway
0.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME OPIOID SIGNALLING	Genes involved in Opioid Signalling
0.1	0.1	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	0.3	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	0.8	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	0.5	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.1	0.1	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.1	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.0	0.0	REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	Genes involved in Activation of the pre-replicative complex
0.0	0.5	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.7	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.9	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.2	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.7	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.3	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.3	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.4	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.4	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.0	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.0	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.1	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.0	0.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.4	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.2	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.0	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.0	0.3	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.2	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.2	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.0	0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.2	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	0.5	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.4	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	0.0	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	0.4	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.0	0.1	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.0	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0	0.2	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.1	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.0	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.1	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions