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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for IRX6_IRX4

Z-value: 0.62

Motif logo

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.7 IRX6
IRX4
ENSG00000113430.5 IRX4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
IRX4chr5_1882240_18825024870.7159710.599.5e-02Click!
IRX4chr5_1881693_188184410900.4185580.521.5e-01Click!
IRX4chr5_1882815_18833932240.8580600.432.5e-01Click!
IRX4chr5_1877685_187783650980.1674100.304.3e-01Click!
IRX4chr5_1876111_187626266720.1585860.294.5e-01Click!
IRX6chr16_55357840_553579912430.9287970.655.6e-02Click!
IRX6chr16_55359119_5535927015220.403624-0.215.9e-01Click!

Activity of the IRX6_IRX4 motif across conditions

Conditions sorted by the z-value of the IRX6_IRX4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr8_95037399_95037630 0.47 ENSG00000263855
 .
 51432
 0.15
chr22_36945126_36945326 0.46 RP5-1119A7.10
2986
 0.2
chr3_125230252_125231290 0.35 ENSG00000201800
 .
 5052
 0.18
chr7_100782348_100782499 0.35 SERPINE1
 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
 12044
 0.1
chr3_154512727_154512878 0.35 MME
 membrane metallo-endopeptidase
 229111
 0.02
chr6_14638853_14639371 0.34 ENSG00000206960
 .
 7654
 0.34
chr9_128409096_128409536 0.34 MAPKAP1
 mitogen-activated protein kinase associated protein 1
 3380
 0.33
chr20_10538984_10539442 0.33 JAG1
 jagged 1
 103941
 0.07
chr15_93457053_93457941 0.33 CHD2
 chromodomain helicase DNA binding protein 2
 9794
 0.2
chr20_51111252_51111403 0.32 ZFP64
 ZFP64 zinc finger protein
 302802
 0.01
chr6_140364803_140364954 0.31 ENSG00000252107
 .
 114953
 0.07
chr8_122361324_122361475 0.30 ENSG00000221644
 .
 162267
 0.04
chr11_122577004_122577557 0.30 ENSG00000239079
 .
 19739
 0.22
chr1_150598433_150598584 0.29 ENSA
 endosulfine alpha
 3084
 0.15
chr3_185411880_185412031 0.28 C3orf65
 chromosome 3 open reading frame 65
 19125
 0.22
chr5_73529344_73529495 0.28 ENSG00000222551
 .
 38171
 0.21
chr8_130709458_130709738 0.28 GSDMC
 gasdermin C
 89536
 0.08
chr4_127860021_127860172 0.27 ENSG00000199862
 .
 89278
 0.11
chr19_9241411_9241562 0.27 OR7G3
 olfactory receptor, family 7, subfamily G, member 3
 3860
 0.15
chr2_3625268_3626011 0.27 ENSG00000252531
 .
 2521
 0.16
chr1_210046746_210046897 0.27 DIEXF
 digestive organ expansion factor homolog (zebrafish)
 34671
 0.15
chr2_32936569_32936720 0.27 TTC27
 tetratricopeptide repeat domain 27
 32699
 0.21
chr5_171382567_171382718 0.27 FBXW11
 F-box and WD repeat domain containing 11
 22118
 0.23
chr20_52354290_52354570 0.26 ENSG00000238468
 .
 69133
 0.12
chr7_12693175_12693326 0.25 ARL4A
 ADP-ribosylation factor-like 4A
 33231
 0.17
chr1_39652074_39652225 0.25 MACF1
 microtubule-actin crosslinking factor 1
 17769
 0.15
chr10_62186857_62187008 0.25 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
 37444
 0.23
chr8_30278565_30278948 0.25 RBPMS
 RNA binding protein with multiple splicing
 21377
 0.21
chr4_169914702_169914853 0.25 ENSG00000201818
 .
 11623
 0.18
chr1_27025127_27026141 0.25 ARID1A
 AT rich interactive domain 1A (SWI-like)
 2739
 0.21
chr2_230718614_230718765 0.24 TRIP12
 thyroid hormone receptor interactor 12
 5309
 0.22
chr6_80255213_80255459 0.24 LCA5
 Leber congenital amaurosis 5
 8161
 0.3
chr3_99565123_99565274 0.24 FILIP1L
 filamin A interacting protein 1-like
 2258
 0.37
chr3_142853615_142853766 0.24 CHST2
 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
 15517
 0.21
chr1_86020329_86020665 0.24 DDAH1
 dimethylarginine dimethylaminohydrolase 1
 23436
 0.17
chr1_243713303_243713454 0.24 RP11-269F20.1
4544
 0.34
chr6_131100314_131100854 0.24 SMLR1
 small leucine-rich protein 1
 47962
 0.18
chr2_217051631_217052157 0.24 AC012513.6
72424
 0.09
chr6_140204883_140205034 0.24 ENSG00000252107
 .
 274873
 0.02
chr4_144273352_144273505 0.23 ENSG00000265623
 .
 8815
 0.21
chr2_1746061_1746328 0.23 PXDN
 peroxidasin homolog (Drosophila)
 2020
 0.44
chr4_187597285_187597436 0.22 FAT1
 FAT atypical cadherin 1
 47649
 0.17
chr4_123703753_123703904 0.22 FGF2
 fibroblast growth factor 2 (basic)
 44035
 0.13
chr1_232558087_232558238 0.22 SIPA1L2
 signal-induced proliferation-associated 1 like 2
 40001
 0.22
chr6_143722656_143722949 0.22 AL031320.1
36773
 0.13
chr15_63802358_63803207 0.22 USP3
 ubiquitin specific peptidase 3
 4863
 0.26
chr6_56555129_56555280 0.22 DST
 dystonin
 47410
 0.18
chr19_6103075_6103226 0.22 CTB-66B24.1
6183
 0.15
chr1_224972610_224972761 0.22 RP11-449J1.1
18083
 0.21
chr5_95430378_95430529 0.22 ENSG00000207578
 .
 15611
 0.25
chr2_179106826_179106977 0.22 OSBPL6
 oxysterol binding protein-like 6
 42753
 0.16
chr7_44454046_44454197 0.21 NUDCD3
 NudC domain containing 3
 76358
 0.08
chr1_22047557_22047882 0.21 USP48
 ubiquitin specific peptidase 48
 3893
 0.26
chr12_25487343_25487617 0.21 ENSG00000201439
 .
 69882
 0.1
chr2_216393689_216393840 0.21 AC012462.1
92788
 0.08
chr7_41727697_41728013 0.21 INHBA-AS1
 INHBA antisense RNA 1
 5659
 0.22
chr9_35497818_35497969 0.21 RUSC2
 RUN and SH3 domain containing 2
 7769
 0.18
chrX_71494679_71495271 0.21 RPS4X
 ribosomal protein S4, X-linked
 2123
 0.24
chr18_51804642_51804943 0.21 POLI
 polymerase (DNA directed) iota
 4484
 0.25
chr1_63187029_63187180 0.21 RP11-230B22.1
32951
 0.16
chr11_103396303_103396486 0.21 DYNC2H1
 dynein, cytoplasmic 2, heavy chain 1
 167423
 0.04
chr5_33306659_33307137 0.21 CTD-2203K17.1
133827
 0.05
chr2_238106047_238106302 0.21 AC112715.2
 Uncharacterized protein
 59560
 0.13
chr3_57963869_57964020 0.21 FLNB
 filamin B, beta
 30183
 0.2
chr2_198836723_198836874 0.21 PLCL1
 phospholipase C-like 1
 111738
 0.07
chr2_210290098_210290249 0.21 MAP2
 microtubule-associated protein 2
 1391
 0.61
chr19_34724547_34724719 0.21 KIAA0355
 KIAA0355
 20809
 0.21
chr12_91522053_91522204 0.20 LUM
 lumican
 16520
 0.21
chr1_178065326_178065477 0.20 RASAL2
 RAS protein activator like 2
 2125
 0.47
chr18_65027187_65027338 0.20 ENSG00000265580
 .
 63743
 0.14
chr11_117184410_117184561 0.20 CEP164
 centrosomal protein 164kDa
 788
 0.54
chr19_10731127_10731278 0.20 SLC44A2
 solute carrier family 44 (choline transporter), member 2
 4732
 0.12
chr17_60904793_60905165 0.20 MARCH10
 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
 19274
 0.23
chr1_186157290_186157441 0.20 GS1-174L6.4
10931
 0.22
chr7_20259929_20260378 0.20 MACC1
 metastasis associated in colon cancer 1
 3126
 0.32
chr3_100008069_100008220 0.20 TBC1D23
 TBC1 domain family, member 23
 9860
 0.2
chr1_205715034_205715185 0.20 NUCKS1
 nuclear casein kinase and cyclin-dependent kinase substrate 1
 4295
 0.17
chr12_9100275_9100426 0.20 M6PR
 mannose-6-phosphate receptor (cation dependent)
 906
 0.49
chr9_97663549_97663700 0.20 RP11-49O14.2
913
 0.6
chr16_89467841_89467992 0.20 RP1-168P16.2
11056
 0.14
chr3_11427274_11427546 0.20 ATG7
 autophagy related 7
 21277
 0.26
chr14_24834583_24834734 0.20 NFATC4
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
 1459
 0.21
chr12_122430745_122430896 0.20 BCL7A
 B-cell CLL/lymphoma 7A
 26508
 0.17
chr2_46542258_46542445 0.19 EPAS1
 endothelial PAS domain protein 1
 17810
 0.25
chr15_101299874_101300025 0.19 ALDH1A3
 aldehyde dehydrogenase 1 family, member A3
 117970
 0.05
chr11_46974144_46974439 0.19 C11orf49
 chromosome 11 open reading frame 49
 15960
 0.18
chr4_81186341_81186492 0.19 FGF5
 fibroblast growth factor 5
 1337
 0.53
chr10_112062798_112063458 0.19 SMNDC1
 survival motor neuron domain containing 1
 1327
 0.53
chr19_16179828_16179979 0.19 TPM4
 tropomyosin 4
 1393
 0.4
chr1_100817300_100817579 0.19 CDC14A
 cell division cycle 14A
 149
 0.96
chr11_33714452_33714603 0.19 RP4-541C22.5
3720
 0.2
chr7_7744988_7745289 0.19 RPA3
 replication protein A3, 14kDa
 13100
 0.25
chrX_55743062_55743213 0.19 RRAGB
 Ras-related GTP binding B
 1035
 0.62
chr2_167993645_167993796 0.19 XIRP2-AS1
 XIRP2 antisense RNA 1
 3745
 0.34
chr6_138976214_138976649 0.19 RP11-390P2.4
37254
 0.17
chr3_183563662_183564003 0.19 PARL
 presenilin associated, rhomboid-like
 1770
 0.27
chr5_57158791_57158942 0.19 ENSG00000266864
 .
 10007
 0.31
chr12_52348007_52348213 0.19 ACVR1B
 activin A receptor, type IB
 946
 0.5
chr15_72525332_72525483 0.19 PKM
 pyruvate kinase, muscle
 1243
 0.4
chr3_141579230_141579381 0.19 ATP1B3
 ATPase, Na+/K+ transporting, beta 3 polypeptide
 15661
 0.18
chr2_165752799_165752950 0.19 ENSG00000223318
 .
 587
 0.74
chr20_43181909_43182060 0.19 PKIG
 protein kinase (cAMP-dependent, catalytic) inhibitor gamma
 21414
 0.13
chr3_149301783_149301934 0.19 WWTR1
 WW domain containing transcription regulator 1
 7819
 0.21
chr3_177246534_177246685 0.18 ENSG00000252028
 .
 25269
 0.26
chr13_33847390_33847541 0.18 ENSG00000236581
 .
 1878
 0.38
chr11_117020661_117020812 0.18 PAFAH1B2
 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
 5676
 0.16
chr3_99614299_99614817 0.18 FILIP1L
 filamin A interacting protein 1-like
 19512
 0.23
chr1_246150119_246150270 0.18 RP11-83A16.1
46659
 0.18
chr1_178061988_178062215 0.18 RASAL2
 RAS protein activator like 2
 763
 0.79
chr16_18970727_18970878 0.18 TMC7
 transmembrane channel-like 7
 24454
 0.12
chr2_67628597_67628898 0.18 ETAA1
 Ewing tumor-associated antigen 1
 4296
 0.38
chr20_36429033_36429188 0.18 CTNNBL1
 catenin, beta like 1
 23435
 0.24
chr10_17066021_17066526 0.18 CUBN
 cubilin (intrinsic factor-cobalamin receptor)
 40079
 0.2
chr17_11939642_11939793 0.18 ENSG00000252707
 .
 237
 0.92
chr2_40079075_40079226 0.18 SLC8A1-AS1
 SLC8A1 antisense RNA 1
 65557
 0.13
chr2_174985605_174985756 0.18 OLA1
 Obg-like ATPase 1
 96994
 0.07
chr4_26621376_26621527 0.18 ENSG00000265627
 .
 17661
 0.22
chr5_105728908_105729059 0.18 ENSG00000252337
 .
 153383
 0.05
chr3_187663809_187663960 0.18 BCL6
 B-cell CLL/lymphoma 6
 200369
 0.02
chr18_22566959_22567110 0.18 ZNF521
 zinc finger protein 521
 237719
 0.02
chr7_129599031_129599182 0.18 ENSG00000207184
 .
 2810
 0.17
chr3_45052908_45053120 0.18 CLEC3B
 C-type lectin domain family 3, member B
 14661
 0.15
chr5_125786033_125786184 0.18 GRAMD3
 GRAM domain containing 3
 11929
 0.22
chr13_98036472_98036623 0.18 ENSG00000202290
 .
 21192
 0.2
chr1_41449008_41449159 0.18 CTPS1
 CTP synthase 1
 250
 0.94
chr15_76348972_76349262 0.18 NRG4
 neuregulin 4
 2952
 0.25
chr8_103252757_103253104 0.18 KB-431C1.4
1308
 0.34
chr5_14264414_14265476 0.18 TRIO
 trio Rho guanine nucleotide exchange factor
 26141
 0.27
chr11_10322719_10322870 0.18 RP11-351I24.1
2457
 0.22
chr14_68698275_68698426 0.18 ENSG00000243546
 .
 4906
 0.3
chr15_41958458_41958609 0.18 MGA
 MGA, MAX dimerization protein
 2493
 0.26
chr4_57915542_57915693 0.18 ENSG00000251703
 .
 46759
 0.1
chr15_71341987_71342266 0.18 THSD4
 thrombospondin, type I, domain containing 4
 47165
 0.15
chr1_234752857_234753272 0.17 IRF2BP2
 interferon regulatory factor 2 binding protein 2
 7793
 0.19
chr17_58439093_58439244 0.17 USP32
 ubiquitin specific peptidase 32
 30168
 0.17
chr9_84386849_84387000 0.17 ENSG00000263404
 .
 34072
 0.17
chr2_73207406_73207767 0.17 EMX1
 empty spiracles homeobox 1
 56469
 0.12
chr1_8065443_8065723 0.17 ERRFI1
 ERBB receptor feedback inhibitor 1
 10110
 0.18
chr12_19174986_19175137 0.17 PLEKHA5
 pleckstrin homology domain containing, family A member 5
 107587
 0.07
chr16_85470909_85471082 0.17 ENSG00000264203
 .
 4103
 0.3
chr8_122931309_122931460 0.17 HAS2-AS1
 HAS2 antisense RNA 1
 277708
 0.01
chr12_50940008_50940333 0.17 DIP2B
 DIP2 disco-interacting protein 2 homolog B (Drosophila)
 41280
 0.15
chr9_12718941_12719092 0.17 TYRP1
 tyrosinase-related protein 1
 23296
 0.2
chr5_131750080_131750814 0.17 C5orf56
 chromosome 5 open reading frame 56
 3766
 0.16
chr14_69535729_69536049 0.17 ENSG00000206768
 .
 74781
 0.09
chr15_33494490_33494641 0.17 FMN1
 formin 1
 7668
 0.29
chr1_154152302_154152968 0.17 TPM3
 tropomyosin 3
 1976
 0.18
chr15_51203212_51203412 0.17 AP4E1
 adaptor-related protein complex 4, epsilon 1 subunit
 2320
 0.4
chr4_169540123_169540274 0.17 PALLD
 palladin, cytoskeletal associated protein
 12568
 0.21
chr4_114880757_114880908 0.17 RP11-26P13.2
16420
 0.24
chr8_104293348_104293656 0.17 RP11-318M2.2
4628
 0.2
chr1_117601173_117601556 0.17 RP11-27K13.3
748
 0.55
chr8_89288165_89288316 0.17 RP11-586K2.1
50825
 0.16
chr13_33836579_33836730 0.16 ENSG00000236581
 .
 8862
 0.23
chr6_143050462_143050730 0.16 RP1-67K17.3
18984
 0.27
chr7_65760902_65761053 0.16 ENSG00000252126
 .
 48314
 0.13
chr6_145276841_145276992 0.16 UTRN
 utrophin
 156399
 0.04
chr4_170174772_170174923 0.16 SH3RF1
 SH3 domain containing ring finger 1
 16261
 0.25
chr8_28982615_28982843 0.16 CTD-2647L4.1
14639
 0.15
chr7_130539521_130539776 0.16 ENSG00000226380
 .
 21932
 0.23
chr7_77496191_77496692 0.16 PHTF2
 putative homeodomain transcription factor 2
 26944
 0.18
chr1_178207539_178207690 0.16 RASAL2
 RAS protein activator like 2
 102992
 0.08
chr15_39288838_39288989 0.16 RP11-624L4.1
122001
 0.06
chr3_71085056_71085207 0.16 FOXP1
 forkhead box P1
 28946
 0.25
chr1_7283919_7284070 0.16 ENSG00000207056
 .
 4574
 0.33
chr4_107506143_107506294 0.16 ENSG00000222333
 .
 169276
 0.04
chr8_13124406_13124699 0.16 DLC1
 deleted in liver cancer 1
 9503
 0.27
chr2_171787186_171787958 0.16 GORASP2
 golgi reassembly stacking protein 2, 55kDa
 1741
 0.39
chr4_174411815_174412157 0.16 HAND2-AS1
 HAND2 antisense RNA 1 (head to head)
 36435
 0.14
chr6_81258118_81258393 0.16 BCKDHB
 branched chain keto acid dehydrogenase E1, beta polypeptide
 441872
 0.01
chr6_16682722_16682873 0.16 RP1-151F17.1
78572
 0.11
chr6_157223655_157223806 0.16 ARID1B
 AT rich interactive domain 1B (SWI1-like)
 1223
 0.62
chr3_149469081_149469660 0.16 COMMD2
 COMM domain containing 2
 916
 0.55
chrX_13450415_13450566 0.16 ATXN3L
 ataxin 3-like
 111972
 0.06
chr11_88288822_88288973 0.16 GRM5-AS1
 GRM5 antisense RNA 1
 43981
 0.18
chr7_129551821_129551972 0.16 UBE2H
 ubiquitin-conjugating enzyme E2H
 39271
 0.11
chr3_25834915_25835066 0.16 OXSM
 3-oxoacyl-ACP synthase, mitochondrial
 2713
 0.25
chr6_37212230_37212381 0.16 ENSG00000238375
 .
 6777
 0.17
chr6_51167339_51167725 0.16 ENSG00000212532
 .
 161956
 0.04
chr4_55529764_55530043 0.16 KIT
 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
 5818
 0.34
chr4_90741767_90741918 0.16 SNCA
 synuclein, alpha (non A4 component of amyloid precursor)
 14989
 0.21
chr5_77973860_77974011 0.16 LHFPL2
 lipoma HMGIC fusion partner-like 2
 29287
 0.25
chr4_41146468_41146619 0.16 ENSG00000207198
 .
 30584
 0.17
chr12_49664011_49664162 0.16 RP11-161H23.5
3003
 0.15
chr5_139555723_139556039 0.16 CYSTM1
 cysteine-rich transmembrane module containing 1
 1654
 0.3
chr11_130819091_130819698 0.16 SNX19
 sorting nexin 19
 32990
 0.21
chr7_21583848_21583999 0.16 DNAH11
 dynein, axonemal, heavy chain 11
 1090
 0.63
chr3_187980787_187980938 0.16 LPP
 LIM domain containing preferred translocation partner in lipoma
 23210
 0.25
chr3_71635193_71635783 0.16 FOXP1
 forkhead box P1
 2348
 0.32
chrX_4628432_4628686 0.15 ENSG00000222834
 .
 8396
 0.33
chr7_75696719_75696870 0.15 MDH2
 malate dehydrogenase 2, NAD (mitochondrial)
 19315
 0.12
chr2_211340830_211341097 0.15 LANCL1
 LanC lantibiotic synthetase component C-like 1 (bacterial)
 466
 0.76
chr4_177927532_177927683 0.15 ENSG00000222859
 .
 174989
 0.03
chr12_76271999_76272150 0.15 ENSG00000243420
 .
 79836
 0.1
chr16_50229405_50229706 0.15 PAPD5
 PAP associated domain containing 5
 41776
 0.12
chr7_120938645_120938796 0.15 WNT16
 wingless-type MMTV integration site family, member 16
 26701
 0.23
chr2_159950478_159950629 0.15 ENSG00000202029
 .
 66899
 0.12
chr20_39686412_39686563 0.15 TOP1
 topoisomerase (DNA) I
 29029
 0.17
chr4_19833823_19833974 0.15 SLIT2
 slit homolog 2 (Drosophila)
 420985
 0.01
chr13_20699448_20699599 0.15 GJA3
 gap junction protein, alpha 3, 46kDa
 35665
 0.16

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of IRX6_IRX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.0 0.1 GO:0046881 positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0009128 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.0 GO:0051832 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:1901532 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.0 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0010586 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.1 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.1 GO:2000178 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.1 GO:0042663 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.0 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0 0.1 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 0.1 GO:0061162 establishment of apical/basal cell polarity(GO:0035089) establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0 0.1 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.0 GO:0014874 response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0 0.1 GO:0060390 regulation of SMAD protein import into nucleus(GO:0060390)
0.0 0.0 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.1 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.0 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0090322 regulation of superoxide metabolic process(GO:0090322)
0.0 0.0 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.0 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.1 GO:0032776 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.0 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.0 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.1 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.1 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.0 GO:0061072 iris morphogenesis(GO:0061072)
0.0 0.1 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.0 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.0 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.0 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.0 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.0 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.0 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.0 GO:0035929 steroid hormone secretion(GO:0035929)
0.0 0.1 GO:0006266 DNA ligation(GO:0006266)
0.0 0.0 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0090399 replicative senescence(GO:0090399)
0.0 0.0 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.0 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.0 GO:0002138 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.0 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.0 GO:0032059 bleb(GO:0032059)
0.0 0.0 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.0 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.1 GO:0043256 laminin complex(GO:0043256)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.0 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.0 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.0 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.0 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.0 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.0 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.0 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 0.0 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.0 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.0 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.0 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.0 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.1 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR