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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for ISL2

Z-value: 1.11

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Transcription factors associated with ISL2

Gene Symbol	Gene ID	Gene Info
ISL2 Ensembl NCBI GeneCards UniProt	ENSG00000159556.5	ISL LIM homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr15_76629131_76629414	ISL2	207	0.940904	0.76	1.8e-02	Click!
chr15_76629584_76629868	ISL2	661	0.709692	0.62	7.4e-02	Click!
chr15_76631040_76631196	ISL2	2053	0.309314	0.51	1.6e-01	Click!
chr15_76628322_76628623	ISL2	593	0.749474	0.48	1.9e-01	Click!
chr15_76628716_76628867	ISL2	274	0.915217	-0.43	2.5e-01	Click!

Activity of the ISL2 motif across conditions

Conditions sorted by the z-value of the ISL2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_24957255_24957453	0.47	FAM65B	family with sequence similarity 65, member B	21166	0.2
chr2_43402387_43402951	0.45	ZFP36L2	ZFP36 ring finger protein-like 2	51079	0.14
chr2_102983409_102983883	0.45	IL18R1	interleukin 18 receptor 1	4525	0.2
chr1_169674701_169674897	0.42	SELL	selectin L	6040	0.21
chr14_61862914_61863071	0.41	PRKCH	protein kinase C, eta	5580	0.27
chr5_79495642_79495793	0.40	ENSG00000239159	.	39691	0.14
chr1_167435126_167435452	0.39	RP11-104L21.2		7391	0.22
chr4_78721201_78721381	0.36	CNOT6L	CCR4-NOT transcription complex, subunit 6-like	18926	0.25
chr5_75472307_75472595	0.36	ENSG00000252833	.	84825	0.09
chr8_19284492_19284750	0.35	SH2D4A	SH2 domain containing 4A	107520	0.08
chr2_10476180_10476331	0.34	HPCAL1	hippocalcin-like 1	32429	0.15
chr12_66788011_66788363	0.33	ENSG00000238528	.	48688	0.15
chr20_5549575_5549726	0.33	GPCPD1	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	6504	0.26
chr10_7554785_7554936	0.33	RP11-385N23.1		20309	0.21
chr5_118678786_118679078	0.32	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	10062	0.21
chr14_75613047_75613445	0.31	NEK9	NIMA-related kinase 9	19199	0.13
chr1_100862907_100863178	0.31	ENSG00000216067	.	18711	0.19
chr4_3198836_3199087	0.31	HTT	huntingtin	36872	0.16
chr7_129520547_129520862	0.31	UBE2H	ubiquitin-conjugating enzyme E2H	70463	0.07
chr13_109064155_109064389	0.31	ENSG00000223177	.	110593	0.07
chr2_190528427_190528617	0.31	ASNSD1	asparagine synthetase domain containing 1	2275	0.28
chr19_19433452_19433603	0.30	MAU2	MAU2 sister chromatid cohesion factor	1732	0.23
chr8_129254431_129254830	0.30	ENSG00000201782	.	21880	0.26
chr16_80690009_80690168	0.30	ENSG00000265341	.	9372	0.18
chr6_52151332_52151486	0.30	MCM3	minichromosome maintenance complex component 3	1774	0.39
chr13_31147115_31147396	0.30	HMGB1	high mobility group box 1	44479	0.17
chr3_107296819_107296970	0.29	BBX	bobby sox homolog (Drosophila)	21266	0.28
chr2_228363055_228363340	0.29	AGFG1	ArfGAP with FG repeats 1	9791	0.22
chr9_95055256_95055438	0.29	ENSG00000239183	.	472	0.52
chr10_22899839_22899998	0.29	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	19276	0.27
chr2_42456564_42456839	0.28	AC083949.1		59260	0.12
chr1_206740198_206740524	0.28	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	9868	0.16
chr13_31182462_31182658	0.28	HMGB1	high mobility group box 1	9174	0.23
chr2_169290019_169290449	0.28	ENSG00000239230	.	7481	0.21
chr15_61101412_61101594	0.28	RP11-554D20.1		44564	0.17
chr21_19162869_19163124	0.28	AL109761.5		2809	0.31
chr3_113942436_113942605	0.27	RP11-553L6.2		9282	0.17
chr1_184812673_184812829	0.27	ENSG00000252222	.	22128	0.2
chr10_112000954_112001185	0.27	MXI1	MAX interactor 1, dimerization protein	13632	0.21
chr12_8240295_8240467	0.27	NECAP1	NECAP endocytosis associated 1	4998	0.16
chr7_8166102_8166400	0.27	AC006042.6		12596	0.21
chr15_22452071_22452222	0.27	IGHV1OR15-1	immunoglobulin heavy variable 1/OR15-1 (non-functional)	3327	0.16
chr7_110617923_110618107	0.27	ENSG00000221279	.	49641	0.18
chr6_90791423_90791574	0.27	ENSG00000222078	.	80273	0.09
chr10_89953557_89953785	0.27	ENSG00000200891	.	199219	0.03
chr6_24928229_24928404	0.27	FAM65B	family with sequence similarity 65, member B	7872	0.24
chr14_98477273_98477437	0.27	C14orf64	chromosome 14 open reading frame 64	32894	0.25
chr2_242038931_242039165	0.27	MTERFD2	MTERF domain containing 2	207	0.92
chr15_87159734_87160062	0.27	RP11-182L7.1		14469	0.3
chr1_33738764_33738963	0.26	ZNF362	zinc finger protein 362	2687	0.23
chr2_198119149_198119485	0.26	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	47926	0.12
chr5_40670263_40670520	0.26	PTGER4	prostaglandin E receptor 4 (subtype EP4)	9209	0.21
chr1_197917676_197917990	0.26	LHX9	LIM homeobox 9	31304	0.2
chr17_38018991_38019172	0.26	IKZF3	IKAROS family zinc finger 3 (Aiolos)	1298	0.36
chrX_44848809_44848960	0.26	KDM6A	lysine (K)-specific demethylase 6A	69643	0.12
chr2_136809392_136809630	0.26	AC093391.2		39476	0.17
chr4_78777778_78777929	0.26	MRPL1	mitochondrial ribosomal protein L1	5821	0.28
chr3_105474089_105474240	0.26	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	53119	0.19
chr5_49710897_49711138	0.26	EMB	embigin	13544	0.32
chr12_68848636_68848957	0.25	MDM1	Mdm1 nuclear protein homolog (mouse)	122635	0.05
chr4_109003466_109003707	0.25	HADH	hydroxyacyl-CoA dehydrogenase	77795	0.09
chr15_89170331_89170558	0.25	AEN	apoptosis enhancing nuclease	5843	0.16
chr8_41821285_41821437	0.25	KAT6A	K(lysine) acetyltransferase 6A	5480	0.25
chr16_11821926_11822083	0.25	TXNDC11	thioredoxin domain containing 11	7982	0.16
chr7_150381782_150381933	0.25	GIMAP2	GTPase, IMAP family member 2	931	0.55
chr12_110905518_110905672	0.25	GPN3	GPN-loop GTPase 3	474	0.49
chr6_167492899_167493153	0.25	CCR6	chemokine (C-C motif) receptor 6	32269	0.15
chr4_26385783_26386117	0.25	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	21798	0.26
chr19_9972790_9973038	0.25	OLFM2	olfactomedin 2	4070	0.12
chr14_102287538_102287689	0.25	CTD-2017C7.2		10955	0.15
chr2_99084461_99084735	0.24	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	23185	0.21
chr11_18643216_18643367	0.24	SPTY2D1	SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)	12749	0.15
chr3_17379285_17379436	0.24	TBC1D5	TBC1 domain family, member 5	68852	0.14
chr5_156623872_156624111	0.24	ITK	IL2-inducible T-cell kinase	16154	0.12
chr5_156969848_156970007	0.24	AC106801.1		23045	0.14
chr7_50411715_50412132	0.24	IKZF1	IKAROS family zinc finger 1 (Ikaros)	44678	0.17
chr1_117048262_117048434	0.24	CD58	CD58 molecule	38864	0.12
chr3_20141266_20141417	0.24	ENSG00000266745	.	37716	0.14
chr9_138981710_138981861	0.24	NACC2	NACC family member 2, BEN and BTB (POZ) domain containing	5346	0.22
chr6_154561193_154561344	0.24	IPCEF1	interaction protein for cytohesin exchange factors 1	6722	0.33
chr16_89851638_89852037	0.24	FANCA	Fanconi anemia, complementation group A	31206	0.1
chr14_81659207_81659358	0.24	ENSG00000221303	.	9896	0.2
chr5_80037332_80037509	0.24	DHFR	dihydrofolate reductase	86618	0.08
chr5_39181205_39181356	0.24	FYB	FYN binding protein	21849	0.24
chr9_95473711_95474015	0.24	IPPK	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	41316	0.14
chr1_111692476_111692627	0.24	CEPT1	choline/ethanolamine phosphotransferase 1	9703	0.13
chr4_79438399_79438550	0.24	ANXA3	annexin A3	34199	0.2
chr11_14655776_14656097	0.24	PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1	9227	0.23
chr16_21829813_21829964	0.24	RRN3P1	RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1	1817	0.34
chr5_61874985_61875174	0.24	LRRC70	leucine rich repeat containing 70	377	0.53
chr10_112637940_112638091	0.23	PDCD4-AS1	PDCD4 antisense RNA 1	6024	0.14
chr14_68758527_68759049	0.23	ENSG00000243546	.	55532	0.15
chr6_118929799_118929950	0.23	CEP85L	centrosomal protein 85kDa-like	43146	0.18
chrX_154491822_154491973	0.23	RAB39B	RAB39B, member RAS oncogene family	1977	0.31
chr3_151972697_151972848	0.23	MBNL1	muscleblind-like splicing regulator 1	13057	0.22
chr2_204818136_204818351	0.23	ICOS	inducible T-cell co-stimulator	16740	0.27
chr1_20649275_20649426	0.23	RP4-745E8.2		330	0.9
chr20_1422496_1422647	0.23	NSFL1C	NSFL1 (p97) cofactor (p47)	24902	0.13
chr1_76733623_76733774	0.23	ST6GALNAC3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	193294	0.03
chr22_17597863_17598182	0.23	CECR6	cat eye syndrome chromosome region, candidate 6	4121	0.17
chr17_40609828_40609979	0.23	ATP6V0A1	ATPase, H+ transporting, lysosomal V0 subunit a1	959	0.38
chr3_143573587_143573820	0.23	SLC9A9	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	6330	0.33
chr5_157280945_157281096	0.23	CLINT1	clathrin interactor 1	5121	0.24
chrX_118709579_118710135	0.23	UBE2A	ubiquitin-conjugating enzyme E2A	1217	0.41
chr10_111860292_111860443	0.23	ADD3	adducin 3 (gamma)	92645	0.07
chr6_11357904_11358055	0.23	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	24553	0.24
chr12_21605567_21605718	0.22	PYROXD1	pyridine nucleotide-disulphide oxidoreductase domain 1	14793	0.17
chr17_35446357_35446690	0.22	ACACA	acetyl-CoA carboxylase alpha	605	0.72
chr2_152279410_152279561	0.22	RIF1	RAP1 interacting factor homolog (yeast)	12881	0.2
chr21_34084761_34084912	0.22	SYNJ1	synaptojanin 1	14370	0.15
chr1_156250674_156250854	0.22	SMG5	SMG5 nonsense mediated mRNA decay factor	1852	0.17
chr6_24937638_24937929	0.22	FAM65B	family with sequence similarity 65, member B	1595	0.45
chr14_22999356_22999596	0.22	TRAJ15	T cell receptor alpha joining 15	896	0.43
chr8_134627256_134627424	0.22	ENSG00000212273	.	29628	0.22
chr7_38348285_38348436	0.22	STARD3NL	STARD3 N-terminal like	130363	0.05
chr12_40009917_40010068	0.22	ABCD2	ATP-binding cassette, sub-family D (ALD), member 2	3561	0.29
chr7_8229957_8230180	0.22	ENSG00000265212	.	35416	0.15
chr2_169965586_169965930	0.22	AC007556.3		8505	0.23
chr6_74158126_74158277	0.22	MB21D1	Mab-21 domain containing 1	3781	0.11
chr2_191880278_191880459	0.22	STAT1	signal transducer and activator of transcription 1, 91kDa	1392	0.36
chr22_36550343_36550563	0.22	APOL3	apolipoprotein L, 3	6378	0.24
chr14_92331009_92331160	0.22	TC2N	tandem C2 domains, nuclear	2789	0.28
chr1_241840160_241840311	0.22	WDR64	WD repeat domain 64	6647	0.23
chr2_61690138_61690289	0.22	USP34	ubiquitin specific peptidase 34	7691	0.19
chr5_67570499_67571170	0.22	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	5234	0.32
chr10_97723999_97724150	0.22	CC2D2B	coiled-coil and C2 domain containing 2B	9712	0.17
chr2_36474188_36474481	0.22	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	108735	0.08
chr12_66712818_66712969	0.22	HELB	helicase (DNA) B	16568	0.16
chr12_123844374_123844525	0.22	SBNO1	strawberry notch homolog 1 (Drosophila)	4926	0.16
chr2_169961679_169961830	0.22	AC007556.3		4501	0.26
chr10_121354997_121355217	0.22	TIAL1	TIA1 cytotoxic granule-associated RNA binding protein-like 1	900	0.65
chr2_135008601_135008752	0.21	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	3154	0.32
chr1_171480370_171480521	0.21	ENSG00000201126	.	8607	0.16
chr13_41168325_41168476	0.21	AL133318.1	Uncharacterized protein	57077	0.13
chr16_29088081_29088232	0.21	RRN3P2	RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2	1813	0.25
chr2_241503761_241504027	0.21	RNPEPL1	arginyl aminopeptidase (aminopeptidase B)-like 1	1327	0.3
chr22_31875988_31876139	0.21	ENSG00000199248	.	588	0.64
chr14_22997541_22997805	0.21	TRAJ15	T cell receptor alpha joining 15	907	0.43
chr1_27037202_27037353	0.21	ARID1A	AT rich interactive domain 1A (SWI-like)	14382	0.14
chr2_42523506_42523974	0.21	EML4	echinoderm microtubule associated protein like 4	4653	0.29
chr21_45512944_45513095	0.21	PWP2	PWP2 periodic tryptophan protein homolog (yeast)	14152	0.16
chr10_14588715_14588906	0.21	FAM107B	family with sequence similarity 107, member B	1859	0.43
chr5_98363313_98363584	0.21	ENSG00000200351	.	90997	0.09
chr5_156652592_156652883	0.21	CTB-4E7.1		1347	0.34
chrX_13106601_13106839	0.21	FAM9C	family with sequence similarity 9, member C	43919	0.18
chr2_68385602_68386003	0.21	PNO1	partner of NOB1 homolog (S. cerevisiae)	826	0.45
chr14_22982131_22982282	0.21	TRAJ15	T cell receptor alpha joining 15	16374	0.1
chr2_173361570_173361807	0.21	ITGA6	integrin, alpha 6	8998	0.17
chr4_109027301_109027793	0.21	LEF1	lymphoid enhancer-binding factor 1	59910	0.12
chr12_52745258_52745409	0.21	KRT85	keratin 85	13073	0.09
chr12_122728078_122728245	0.21	VPS33A	vacuolar protein sorting 33 homolog A (S. cerevisiae)	6551	0.16
chr7_38273243_38273394	0.21	STARD3NL	STARD3 N-terminal like	55321	0.17
chr3_45984585_45984736	0.21	CXCR6	chemokine (C-X-C motif) receptor 6	304	0.88
chr1_91488978_91489129	0.21	ZNF644	zinc finger protein 644	1224	0.65
chr8_91015719_91015870	0.21	DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	2049	0.36
chr14_52378888_52379324	0.21	GNG2	guanine nucleotide binding protein (G protein), gamma 2	724	0.64
chr5_60242105_60242256	0.21	NDUFAF2	NADH dehydrogenase (ubiquinone) complex I, assembly factor 2	1018	0.43
chr2_106383531_106383975	0.21	NCK2	NCK adaptor protein 2	21565	0.26
chr17_37970513_37970744	0.21	IKZF3	IKAROS family zinc finger 3 (Aiolos)	36150	0.11
chrY_15019193_15019499	0.21	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked	1697	0.5
chr11_95393542_95393693	0.21	FAM76B	family with sequence similarity 76, member B	126352	0.05
chr7_138768806_138768957	0.21	ZC3HAV1	zinc finger CCCH-type, antiviral 1	4868	0.24
chr8_95946914_95947065	0.21	TP53INP1	tumor protein p53 inducible nuclear protein 1	6212	0.14
chr21_48041777_48042182	0.21	PRMT2	protein arginine methyltransferase 2	13100	0.2
chr5_114960864_114961097	0.21	TMED7-TICAM2	TMED7-TICAM2 readthrough	731	0.35
chr16_50353145_50353296	0.21	BRD7	bromodomain containing 7	620	0.72
chr4_6185422_6185754	0.21	JAKMIP1	janus kinase and microtubule interacting protein 1	10756	0.28
chr8_129288885_129289036	0.21	ENSG00000201782	.	56210	0.16
chr17_47825562_47826034	0.21	FAM117A	family with sequence similarity 117, member A	15695	0.14
chr10_121052972_121053123	0.21	RP11-79M19.2		42647	0.13
chr6_106628525_106628811	0.21	RP1-134E15.3		80653	0.08
chr17_71720142_71720293	0.20	SDK2	sidekick cell adhesion molecule 2	79989	0.1
chr7_158505018_158505235	0.20	NCAPG2	non-SMC condensin II complex, subunit G2	7606	0.23
chr7_24599893_24600044	0.20	MPP6	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	12919	0.24
chr7_130762233_130762492	0.20	LINC-PINT	long intergenic non-protein coding RNA, p53 induced transcript	10871	0.21
chr3_71519493_71519644	0.20	ENSG00000221264	.	71672	0.11
chr17_8322444_8322595	0.20	NDEL1	nudE neurodevelopment protein 1-like 1	6070	0.13
chr8_48273740_48273891	0.20	SPIDR	scaffolding protein involved in DNA repair	79148	0.11
chr1_51424938_51425361	0.20	FAF1	Fas (TNFRSF6) associated factor 1	684	0.61
chr18_60863511_60863662	0.20	ENSG00000238988	.	1688	0.43
chr1_180413710_180413861	0.20	ENSG00000265435	.	6260	0.25
chr3_18432297_18432593	0.20	RP11-158G18.1		18682	0.22
chr22_40730742_40730944	0.20	ADSL	adenylosuccinate lyase	11664	0.19
chr4_153369279_153369489	0.20	FBXW7	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	35626	0.17
chr1_67894294_67894445	0.20	SERBP1	SERPINE1 mRNA binding protein 1	1686	0.4
chr5_148819447_148819755	0.20	ENSG00000269936	.	9392	0.15
chr12_107148013_107148164	0.20	RIC8B	RIC8 guanine nucleotide exchange factor B	20285	0.16
chr12_9915687_9916017	0.20	CD69	CD69 molecule	2355	0.25
chr4_78709146_78709320	0.20	CNOT6L	CCR4-NOT transcription complex, subunit 6-like	30984	0.21
chrX_124428781_124429080	0.20	ENSG00000263886	.	7305	0.34
chr1_24839011_24839397	0.20	RCAN3	RCAN family member 3	1606	0.35
chr8_126945463_126945895	0.20	ENSG00000206695	.	32484	0.25
chr12_12688522_12688673	0.20	DUSP16	dual specificity phosphatase 16	14538	0.23
chr8_101940980_101941155	0.20	YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta	6216	0.18
chr11_104578420_104578571	0.20	CASP12	caspase 12 (gene/pseudogene)	190646	0.03
chr3_141209377_141209555	0.20	RASA2	RAS p21 protein activator 2	3575	0.28
chr14_69608386_69608580	0.20	ENSG00000206768	.	2187	0.32
chr5_118614574_118614744	0.20	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	10210	0.19
chr17_47766059_47766212	0.20	SPOP	speckle-type POZ protein	10539	0.14
chr2_68589737_68589888	0.20	PLEK	pleckstrin	2493	0.24

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.1	0.5	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.4	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.3	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.1	0.5	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.1	0.4	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.7	GO:0006491	N-glycan processing(GO:0006491)
0.1	0.3	GO:0001711	endodermal cell fate commitment(GO:0001711) endodermal cell differentiation(GO:0035987)
0.1	0.2	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.1	0.3	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.2	GO:0002913	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.1	0.1	GO:0002507	tolerance induction(GO:0002507)
0.1	0.2	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.2	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1	0.2	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.2	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1	0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.3	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.2	GO:1901985	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.1	0.2	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.2	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.1	0.2	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.1	0.1	GO:0002664	tolerance induction to self antigen(GO:0002513) T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.1	0.4	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.2	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	0.1	GO:0002643	regulation of tolerance induction(GO:0002643) positive regulation of tolerance induction(GO:0002645)
0.1	0.2	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.1	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.1	0.2	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.1	0.1	GO:0002335	mature B cell differentiation(GO:0002335)
0.1	0.2	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.2	GO:0002407	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.1	0.2	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.2	GO:0000042	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.1	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.2	GO:0001779	natural killer cell differentiation(GO:0001779)
0.0	0.4	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.2	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0	0.1	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.1	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.1	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0	0.1	GO:0071921	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.0	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.2	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.2	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.0	GO:0010916	regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	2.9	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0046398	UDP-glucuronate metabolic process(GO:0046398)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0034776	response to histamine(GO:0034776)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.2	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.2	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.0	GO:0031223	auditory behavior(GO:0031223)
0.0	0.0	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.2	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.4	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.0	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0035609	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.2	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.1	GO:0006378	mRNA polyadenylation(GO:0006378)
0.0	0.1	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.0	GO:0002468	dendritic cell antigen processing and presentation(GO:0002468) regulation of dendritic cell antigen processing and presentation(GO:0002604) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.2	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	0.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.3	GO:0045022	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.2	GO:0048617	embryonic foregut morphogenesis(GO:0048617)
0.0	0.2	GO:0000132	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.5	GO:0060334	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0	0.2	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.3	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0032933	SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.0	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.0	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.0	GO:0048548	regulation of pinocytosis(GO:0048548)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.1	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.1	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0032621	interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661)
0.0	0.0	GO:2000649	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.4	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.1	GO:0071025	RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.2	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.0	GO:0060413	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.1	GO:0097501	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.1	GO:0071699	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.3	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.0	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.0	GO:0051459	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.1	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.0	GO:0042109	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.0	GO:1902745	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0051096	positive regulation of helicase activity(GO:0051096)
0.0	0.1	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.0	GO:0002820	negative regulation of adaptive immune response(GO:0002820) negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains(GO:0002823)
0.0	0.1	GO:0006303	double-strand break repair via nonhomologous end joining(GO:0006303)
0.0	0.1	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0006545	glycine biosynthetic process(GO:0006545)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.0	GO:0015809	arginine transport(GO:0015809)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.3	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.0	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.1	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.1	GO:0048291	isotype switching to IgG isotypes(GO:0048291)
0.0	0.1	GO:0019060	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.2	GO:0002714	positive regulation of B cell mediated immunity(GO:0002714) positive regulation of immunoglobulin mediated immune response(GO:0002891)
0.0	0.0	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0000098	sulfur amino acid catabolic process(GO:0000098)
0.0	0.1	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.0	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.0	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.0	0.1	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0034086	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.1	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.0	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.1	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.1	GO:0032693	negative regulation of interleukin-10 production(GO:0032693)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.0	GO:0007063	regulation of sister chromatid cohesion(GO:0007063)
0.0	0.1	GO:0032878	regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0	0.0	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.0	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.2	GO:0042994	cytoplasmic sequestering of transcription factor(GO:0042994)
0.0	0.0	GO:0006266	DNA ligation(GO:0006266)
0.0	0.0	GO:0072599	protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0035092	sperm chromatin condensation(GO:0035092)
0.0	0.2	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0003351	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0021681	cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:0018344	protein geranylgeranylation(GO:0018344)
0.0	0.0	GO:0034371	chylomicron remodeling(GO:0034371)
0.0	0.3	GO:0046677	response to antibiotic(GO:0046677)
0.0	0.0	GO:0035588	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:0006390	mitochondrial RNA metabolic process(GO:0000959) transcription from mitochondrial promoter(GO:0006390)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.0	GO:0030241	skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.1	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.0	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.0	GO:0032715	negative regulation of interleukin-6 production(GO:0032715)
0.0	0.0	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.2	GO:0001504	neurotransmitter uptake(GO:0001504) import into cell(GO:0098657)
0.0	0.0	GO:2000846	corticosteroid hormone secretion(GO:0035930) regulation of steroid hormone secretion(GO:2000831) regulation of corticosteroid hormone secretion(GO:2000846)
0.0	0.0	GO:0060789	hair follicle placode formation(GO:0060789)
0.0	0.1	GO:0006308	DNA catabolic process(GO:0006308)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.4	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0	0.1	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.3	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
0.0	0.1	GO:1901072	amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.1	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.0	GO:0042435	indole-containing compound biosynthetic process(GO:0042435)
0.0	0.1	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.2	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0	0.0	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.0	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.0	GO:0032803	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.0	GO:0010310	regulation of hydrogen peroxide metabolic process(GO:0010310)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0045359	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.3	GO:0006306	DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0	0.0	GO:0019883	antigen processing and presentation of endogenous antigen(GO:0019883)
0.0	0.0	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.1	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.1	GO:0042117	monocyte activation(GO:0042117)
0.0	0.1	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.2	GO:0075733	multi-organism transport(GO:0044766) transport of virus(GO:0046794) intracellular transport of virus(GO:0075733) multi-organism localization(GO:1902579) multi-organism intracellular transport(GO:1902583)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0	0.1	GO:0000154	rRNA modification(GO:0000154)
0.0	0.3	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.1	GO:0060017	parathyroid gland development(GO:0060017)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0	0.0	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0	0.0	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.0	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.0	GO:0042362	fat-soluble vitamin biosynthetic process(GO:0042362)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0070265	necrotic cell death(GO:0070265)
0.0	0.1	GO:0031848	telomere capping(GO:0016233) protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.0	GO:0006047	UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0	0.1	GO:0002031	G-protein coupled receptor internalization(GO:0002031)
0.0	0.0	GO:0002475	antigen processing and presentation via MHC class Ib(GO:0002475)
0.0	0.1	GO:0048255	RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0	0.4	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0000303	response to superoxide(GO:0000303)
0.0	0.0	GO:0032100	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.0	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.1	GO:0009113	purine nucleobase biosynthetic process(GO:0009113)
0.0	0.1	GO:0042130	negative regulation of T cell proliferation(GO:0042130)
0.0	0.1	GO:0045040	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.1	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.1	GO:0033683	nucleotide-excision repair, DNA incision(GO:0033683)
0.0	0.1	GO:0031663	lipopolysaccharide-mediated signaling pathway(GO:0031663)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0051775	response to redox state(GO:0051775)
0.0	0.0	GO:0010533	regulation of activation of Janus kinase activity(GO:0010533) positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	0.0	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.0	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.1	GO:0042987	amyloid precursor protein catabolic process(GO:0042987)
0.0	0.0	GO:1904358	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.0	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.2	GO:0007030	Golgi organization(GO:0007030)
0.0	0.0	GO:1902803	regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0	0.0	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.6	GO:0006921	cellular component disassembly involved in execution phase of apoptosis(GO:0006921) execution phase of apoptosis(GO:0097194)
0.0	0.0	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0048199	vesicle targeting, to, from or within Golgi(GO:0048199)
0.0	0.1	GO:0051220	cytoplasmic sequestering of protein(GO:0051220)
0.0	0.2	GO:0045730	respiratory burst(GO:0045730)
0.0	0.1	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.1	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.0	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.0	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.1	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	0.1	GO:0002532	production of molecular mediator involved in inflammatory response(GO:0002532)
0.0	0.0	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.2	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.3	GO:0006270	DNA replication initiation(GO:0006270)
0.0	0.2	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.1	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.1	GO:0046149	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.0	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.0	0.0	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.0	GO:0051593	response to folic acid(GO:0051593)
0.0	0.0	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.0	GO:0043029	T cell homeostasis(GO:0043029)
0.0	0.8	GO:0018279	peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0	0.0	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.0	GO:0015886	heme transport(GO:0015886)
0.0	0.1	GO:0000050	urea cycle(GO:0000050)
0.0	0.0	GO:0051590	positive regulation of neurotransmitter transport(GO:0051590)
0.0	0.0	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.0	0.1	GO:0008089	anterograde axonal transport(GO:0008089)
0.0	0.1	GO:0048024	regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0	0.0	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.1	GO:0048679	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.2	GO:0032444	activin responsive factor complex(GO:0032444)
0.1	0.2	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.3	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	0.3	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.1	0.2	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.2	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.4	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.2	GO:0042382	paraspeckles(GO:0042382)
0.0	0.2	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.2	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.4	GO:0043209	myelin sheath(GO:0043209)
0.0	0.0	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.0	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.3	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.4	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.2	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:0042627	chylomicron(GO:0042627)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.2	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.1	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.4	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0045240	dihydrolipoyl dehydrogenase complex(GO:0045240)
0.0	0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.2	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.2	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.1	GO:0045120	pronucleus(GO:0045120)
0.0	0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.1	GO:0005838	proteasome regulatory particle(GO:0005838)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0045335	phagocytic vesicle(GO:0045335)
0.0	0.1	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0030897	HOPS complex(GO:0030897)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.0	GO:0001652	granular component(GO:0001652)
0.0	0.5	GO:0030175	filopodium(GO:0030175)
0.0	0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.2	GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.1	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0030914	STAGA complex(GO:0030914)
0.0	0.2	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.5	GO:0015030	Cajal body(GO:0015030)
0.0	0.1	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.0	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.0	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.0	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.1	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.0	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.2	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.1	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	0.0	GO:0000800	lateral element(GO:0000800)
0.0	0.2	GO:0044665	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.2	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.1	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.0	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.4	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	0.2	GO:0033691	sialic acid binding(GO:0033691)
0.1	0.3	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	0.4	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.1	0.2	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.1	0.2	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.2	GO:0042608	T cell receptor binding(GO:0042608)
0.1	0.2	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1	0.5	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.1	0.2	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.8	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.4	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.9	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.3	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.1	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.2	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.2	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.1	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.3	GO:0016274	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.2	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.4	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.3	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	0.2	GO:0060229	lipase activator activity(GO:0060229)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.2	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.3	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0045309	protein phosphorylated amino acid binding(GO:0045309)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.7	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.2	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.2	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.4	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.3	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.0	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.3	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	1.1	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.3	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.2	GO:0005283	sodium:amino acid symporter activity(GO:0005283)
0.0	0.2	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.0	GO:0035198	miRNA binding(GO:0035198)
0.0	0.3	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.1	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	1.0	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	1.3	GO:0004221	obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0	0.2	GO:0005123	death receptor binding(GO:0005123)
0.0	0.1	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.2	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.2	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.1	GO:0032356	single guanine insertion binding(GO:0032142) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.5	GO:0043130	ubiquitin binding(GO:0043130)
0.0	0.0	GO:0005416	cation:amino acid symporter activity(GO:0005416)
0.0	0.2	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.1	GO:0015278	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.1	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.0	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.0	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.0	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.2	GO:0043022	ribosome binding(GO:0043022)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.5	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0	0.1	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.5	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.1	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.2	GO:0010181	FMN binding(GO:0010181)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.0	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.3	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.0	0.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0003747	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.0	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.3	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.2	GO:0051059	NF-kappaB binding(GO:0051059)
0.0	0.1	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0004551	nucleotide diphosphatase activity(GO:0004551)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.0	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.1	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.0	GO:0004952	dopamine neurotransmitter receptor activity(GO:0004952)
0.0	0.3	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.0	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0	0.1	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.0	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.2	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.0	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.0	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.0	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.1	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.0	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.0	GO:0005113	patched binding(GO:0005113)
0.0	0.2	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.2	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.0	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.0	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.1	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.0	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.3	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.0	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.0	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.0	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.1	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.0	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0017069	snRNA binding(GO:0017069)
0.0	0.0	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.2	GO:0005484	SNAP receptor activity(GO:0005484)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	3.1	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.3	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.1	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.3	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.4	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	1.1	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.5	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	1.3	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.5	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.4	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.3	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.4	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.3	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.2	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.3	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.4	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.3	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.4	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.1	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	0.4	PID MYC PATHWAY	C-MYC pathway
0.0	0.3	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	0.1	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.2	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.2	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	0.5	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.2	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.0	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	0.5	PID P53 REGULATION PATHWAY	p53 pathway
0.0	0.1	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	0.1	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.1	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.1	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.0	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	1.0	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.2	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	0.8	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	0.5	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.3	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.3	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.6	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.1	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.5	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.4	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.8	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.5	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.2	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.3	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.3	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.0	0.6	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.4	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.4	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.2	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.6	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.5	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.3	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.0	REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	Genes involved in p53-Dependent G1 DNA Damage Response
0.0	0.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.3	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.5	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.0	0.0	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.1	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.7	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.1	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.3	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.2	REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.0	0.2	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	0.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.2	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.2	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.2	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.3	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.2	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.4	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.1	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.0	0.3	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.4	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.2	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.3	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	0.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.1	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.1	REACTOME PKB MEDIATED EVENTS	Genes involved in PKB-mediated events
0.0	0.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.5	REACTOME TRNA AMINOACYLATION	Genes involved in tRNA Aminoacylation
0.0	0.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.2	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.2	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.1	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.1	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	1.3	REACTOME MRNA PROCESSING	Genes involved in mRNA Processing
0.0	0.1	REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX	Genes involved in TRAF6 mediated induction of TAK1 complex
0.0	0.0	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.1	REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0	0.0	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.0	0.1	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0	0.5	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	0.4	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	0.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	0.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand

Results for ISL2

Z-value: 1.11

Motif logo

Transcription factors associated with ISL2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the ISL2 motif across conditions

Conditions sorted by the z-value of the ISL2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: