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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for KLF1

Z-value: 2.06

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Transcription factors associated with KLF1

Gene Symbol	Gene ID	Gene Info
KLF1 Ensembl NCBI GeneCards UniProt	ENSG00000105610.4	Kruppel like factor 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr19_12996557_12997061	KLF1	1186	0.201684	0.66	5.4e-02	Click!
chr19_12996010_12996205	KLF1	1888	0.120145	-0.48	1.9e-01	Click!
chr19_12995388_12995986	KLF1	2308	0.099733	0.32	4.0e-01	Click!
chr19_12997876_12998027	KLF1	44	0.918445	-0.23	5.6e-01	Click!
chr19_12996291_12996442	KLF1	1629	0.140044	-0.13	7.3e-01	Click!

Activity of the KLF1 motif across conditions

Conditions sorted by the z-value of the KLF1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_158656716_158656867	0.95	WDR60	WD repeat domain 60	5346	0.27
chr2_237657369_237658039	0.95	ACKR3	atypical chemokine receptor 3	179420	0.03
chr1_154979701_154979987	0.84	ZBTB7B	zinc finger and BTB domain containing 7B	4549	0.08
chr19_13113558_13113812	0.82	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	7033	0.09
chr1_21629611_21629762	0.82	ECE1	endothelin converting enzyme 1	4194	0.22
chr2_86055197_86055348	0.77	ENSG00000252321	.	7537	0.17
chr9_137444423_137444866	0.77	COL5A1	collagen, type V, alpha 1	88976	0.08
chr3_47447809_47448062	0.76	PTPN23	protein tyrosine phosphatase, non-receptor type 23	25425	0.13
chr11_7686997_7687148	0.69	CYB5R2	cytochrome b5 reductase 2	7631	0.17
chr20_35504605_35504756	0.69	TLDC2	TBC/LysM-associated domain containing 2	146	0.95
chr1_225925038_225925189	0.68	RP11-145A3.2		1137	0.42
chr17_79064346_79064714	0.66	BAIAP2	BAI1-associated protein 2	4269	0.14
chr1_6238952_6239103	0.65	CHD5	chromodomain helicase DNA binding protein 5	1156	0.38
chr6_36684328_36684602	0.64	RAB44	RAB44, member RAS oncogene family	1209	0.43
chr11_119560225_119560376	0.64	ENSG00000199217	.	33279	0.14
chr8_22847555_22847827	0.63	RHOBTB2	Rho-related BTB domain containing 2	2696	0.18
chr8_143758469_143758620	0.62	PSCA	prostate stem cell antigen	3330	0.15
chr5_149887043_149887237	0.62	NDST1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	534	0.77
chr22_18433540_18433818	0.61	ENSG00000207780	.	30048	0.14
chr22_37905149_37905300	0.61	CARD10	caspase recruitment domain family, member 10	68	0.96
chr10_79321861_79322012	0.60	ENSG00000199592	.	24871	0.23
chr10_126029743_126029894	0.60	OAT	ornithine aminotransferase	77687	0.1
chr1_94204227_94204378	0.59	RP11-488P3.1		36698	0.17
chr19_9957964_9958210	0.59	ENSG00000266247	.	4017	0.11
chr2_241391028_241391179	0.59	GPC1	glypican 1	1125	0.42
chr9_130298577_130298728	0.58	FAM129B	family with sequence similarity 129, member B	32715	0.13
chr3_48538894_48539045	0.57	SHISA5	shisa family member 5	2593	0.15
chr5_16820384_16820535	0.57	ENSG00000253093	.	33644	0.2
chr1_94511054_94511205	0.57	ABCA4	ATP-binding cassette, sub-family A (ABC1), member 4	26901	0.2
chr1_32155176_32155569	0.56	COL16A1	collagen, type XVI, alpha 1	6023	0.15
chr16_89436687_89437018	0.56	ANKRD11	ankyrin repeat domain 11	41458	0.09
chr21_44465729_44466640	0.56	CBS	cystathionine-beta-synthase	12867	0.18
chr2_20412540_20412691	0.55	SDC1	syndecan 1	11426	0.17
chr17_26439314_26439465	0.55	ENSG00000252283	.	50396	0.1
chr17_76405529_76405680	0.55	PGS1	phosphatidylglycerophosphate synthase 1	5559	0.15
chr1_2431468_2431763	0.55	RP3-395M20.3		5697	0.11
chr2_119967496_119967647	0.54	STEAP3	STEAP family member 3, metalloreductase	13813	0.19
chr17_72364891_72365060	0.54	GPR142	G protein-coupled receptor 142	1378	0.3
chr1_205249223_205249374	0.54	TMCC2	transmembrane and coiled-coil domain family 2	23969	0.14
chr6_33546571_33546722	0.54	BAK1	BCL2-antagonist/killer 1	1335	0.33
chr10_50016038_50016189	0.53	WDFY4	WDFY family member 4	5330	0.26
chr17_16977412_16977763	0.53	MPRIP-AS1	MPRIP antisense RNA 1	3479	0.23
chr10_50398424_50398575	0.53	C10orf128	chromosome 10 open reading frame 128	2063	0.33
chr11_67190760_67190911	0.52	PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	2181	0.11
chr8_144657419_144657635	0.52	RP11-661A12.9		1867	0.12
chr3_195949731_195949882	0.52	SLC51A	solute carrier family 51, alpha subunit	5043	0.14
chr20_62317786_62317937	0.52	RTEL1	regulator of telomere elongation helicase 1	1831	0.18
chr12_122235279_122235721	0.51	RHOF	ras homolog family member F (in filopodia)	3083	0.21
chr10_82245535_82245824	0.51	TSPAN14	tetraspanin 14	26621	0.17
chr2_144480307_144480458	0.51	RP11-434H14.1		18481	0.21
chr13_27883554_27883724	0.51	ENSG00000221756	.	10511	0.14
chr9_124396687_124396838	0.50	DAB2IP	DAB2 interacting protein	17111	0.22
chr16_89699348_89699594	0.50	DPEP1	dipeptidase 1 (renal)	2774	0.15
chr6_138213965_138214116	0.49	RP11-356I2.4		24670	0.2
chr12_122468255_122468406	0.49	BCL7A	B-cell CLL/lymphoma 7A	8538	0.22
chr8_144302255_144302406	0.49	GPIHBP1	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	7262	0.14
chr8_129789388_129789539	0.49	ENSG00000221351	.	42577	0.22
chr17_79386350_79386501	0.48	ENSG00000266392	.	11847	0.11
chr9_132465308_132465459	0.48	RP11-483H20.6		15531	0.14
chr2_217501804_217502154	0.48	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	3861	0.22
chr12_111831727_111831878	0.48	SH2B3	SH2B adaptor protein 3	11950	0.18
chr11_2734182_2734333	0.48	KCNQ1OT1	KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)	13033	0.24
chr11_72902349_72902500	0.47	RP11-800A3.2		24534	0.14
chr19_40440819_40441084	0.47	FCGBP	Fc fragment of IgG binding protein	418	0.82
chr3_124880829_124880980	0.47	ENSG00000264986	.	10508	0.19
chr18_32989920_32990179	0.47	ZNF396	zinc finger protein 396	32748	0.17
chr16_3041774_3041925	0.47	PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	11309	0.06
chr11_2411400_2411766	0.47	CD81	CD81 molecule	258	0.86
chr9_130906009_130906346	0.47	LCN2	lipocalin 2	5173	0.09
chr17_2115110_2115261	0.47	SMG6	SMG6 nonsense mediated mRNA decay factor	846	0.42
chr7_1164785_1164936	0.47	C7orf50	chromosome 7 open reading frame 50	13016	0.12
chr9_137247824_137248108	0.46	ENSG00000263897	.	23291	0.21
chr10_49196316_49196467	0.46	FAM25C	family with sequence similarity 25, member C	11427	0.23
chr9_131398817_131398968	0.46	WDR34	WD repeat domain 34	20068	0.11
chr2_64558219_64558458	0.46	ENSG00000264297	.	9555	0.26
chr10_45476036_45476374	0.46	C10orf10	chromosome 10 open reading frame 10	1947	0.22
chr17_76247695_76247857	0.45	TMEM235	transmembrane protein 235	19654	0.13
chr11_12112374_12112662	0.45	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	3025	0.36
chr1_36771499_36771945	0.45	SH3D21	SH3 domain containing 21	266	0.89
chr1_64179739_64179890	0.44	ENSG00000244256	.	58400	0.12
chr15_86315521_86315672	0.44	ENSG00000221634	.	1787	0.23
chr7_158750678_158750919	0.44	ENSG00000231419	.	50314	0.16
chr8_67030629_67031150	0.44	TRIM55	tripartite motif containing 55	8242	0.26
chr9_136926080_136926374	0.44	BRD3	bromodomain containing 3	5093	0.18
chr10_125846427_125846578	0.44	CHST15	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	5468	0.31
chr6_35460175_35460326	0.43	TEAD3	TEA domain family member 3	4477	0.19
chr5_149903159_149903581	0.43	NDST1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	15696	0.16
chr1_183221071_183221222	0.43	NMNAT2	nicotinamide nucleotide adenylyltransferase 2	52863	0.14
chr10_82264968_82265119	0.43	RP11-137H2.4		30655	0.16
chr2_28600761_28600914	0.43	FOSL2	FOS-like antigen 2	14832	0.16
chr18_74779636_74780174	0.43	MBP	myelin basic protein	37312	0.2
chr8_25088407_25088558	0.43	DOCK5	dedicator of cytokinesis 5	46102	0.16
chr17_71537670_71537821	0.43	RP11-449L23.3		21760	0.2
chr20_60926120_60926271	0.42	RP11-157P1.5		1856	0.23
chr12_6321121_6321344	0.42	CD9	CD9 molecule	11269	0.18
chr5_130869288_130869613	0.42	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	724	0.8
chr11_65257627_65258285	0.42	SCYL1	SCY1-like 1 (S. cerevisiae)	34592	0.08
chr12_123619407_123619701	0.42	PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2	15008	0.17
chr2_68942118_68942311	0.41	ARHGAP25	Rho GTPase activating protein 25	4580	0.29
chr2_134938887_134939038	0.41	ENSG00000222921	.	49804	0.15
chr14_35839032_35839183	0.41	NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	34239	0.18
chr1_43472890_43473041	0.41	ENSG00000207256	.	15856	0.16
chr16_57418424_57418638	0.41	CX3CL1	chemokine (C-X3-C motif) ligand 1	7647	0.14
chr2_102603897_102604048	0.41	IL1R2	interleukin 1 receptor, type II	4334	0.3
chr10_80908519_80908825	0.40	ZMIZ1	zinc finger, MIZ-type containing 1	79880	0.1
chr14_77512064_77512283	0.40	IRF2BPL	interferon regulatory factor 2 binding protein-like	17139	0.17
chr11_64951007_64951158	0.40	CAPN1	calpain 1, (mu/I) large subunit	275	0.8
chr10_129843874_129844131	0.40	PTPRE	protein tyrosine phosphatase, receptor type, E	1668	0.5
chr17_7348880_7349137	0.40	CHRNB1	cholinergic receptor, nicotinic, beta 1 (muscle)	158	0.84
chr20_4878879_4879030	0.40	SLC23A2	solute carrier family 23 (ascorbic acid transporter), member 2	1339	0.42
chr17_201097_201248	0.39	RP11-1260E13.2		1257	0.28
chr9_137248525_137248692	0.39	ENSG00000263897	.	22649	0.21
chr8_103757441_103757701	0.39	ENSG00000266799	.	11624	0.23
chr16_2173270_2173421	0.39	RP11-304L19.2		4137	0.06
chr10_81915562_81915788	0.39	ANXA11	annexin A11	6093	0.21
chr16_11654458_11655352	0.39	LITAF	lipopolysaccharide-induced TNF factor	25324	0.15
chr3_45062662_45062813	0.39	CLEC3B	C-type lectin domain family 3, member B	4938	0.19
chr15_100016511_100016662	0.39	MEF2A	myocyte enhancer factor 2A	784	0.68
chr3_48636605_48636768	0.39	COL7A1	collagen, type VII, alpha 1	3986	0.11
chr2_15829588_15829739	0.39	AC008278.3		9055	0.22
chr4_143321954_143322429	0.38	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	30221	0.27
chr8_22439472_22439623	0.38	PDLIM2	PDZ and LIM domain 2 (mystique)	1505	0.23
chr20_18688451_18688602	0.38	RP11-379J5.5		9173	0.23
chr9_114614005_114614347	0.38	ENSG00000206907	.	12068	0.2
chr6_39171595_39171746	0.38	KCNK5	potassium channel, subfamily K, member 5	25556	0.22
chr22_39486625_39486957	0.38	RP4-742C19.12		800	0.52
chr8_141146867_141147018	0.38	C8orf17	chromosome 8 open reading frame 17	203526	0.03
chr22_38291291_38291442	0.38	ENSG00000207227	.	4012	0.12
chr8_28246819_28246970	0.38	ZNF395	zinc finger protein 395	2911	0.2
chr18_43232666_43232907	0.38	RP11-116O18.1		6668	0.21
chr9_124497789_124497940	0.38	DAB2IP	DAB2 interacting protein	7200	0.28
chr5_131590562_131590713	0.38	PDLIM4	PDZ and LIM domain 4	2727	0.23
chr1_161170632_161171366	0.38	NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	938	0.27
chr10_47170047_47170291	0.37	ANXA8L1	annexin A8-like 1	3825	0.18
chrX_153632756_153632907	0.37	DNASE1L1	deoxyribonuclease I-like 1	1120	0.25
chr10_105210970_105211151	0.37	CALHM2	calcium homeostasis modulator 2	1015	0.26
chr3_49943488_49944003	0.37	CTD-2330K9.3	Uncharacterized protein	2325	0.15
chr19_14608235_14608386	0.37	GIPC1	GIPC PDZ domain containing family, member 1	1366	0.27
chr1_46668774_46668925	0.37	LURAP1	leucine rich adaptor protein 1	157	0.93
chr11_119584963_119585114	0.37	PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	14225	0.19
chr19_16994459_16994610	0.37	F2RL3	coagulation factor II (thrombin) receptor-like 3	5137	0.13
chr14_65142113_65142264	0.37	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	28632	0.17
chr19_15947461_15947612	0.37	OR10H1	olfactory receptor, family 10, subfamily H, member 1	28600	0.14
chr11_57125235_57125386	0.37	ENSG00000266018	.	1886	0.18
chr17_74486749_74486900	0.37	RHBDF2	rhomboid 5 homolog 2 (Drosophila)	2412	0.17
chr7_2549413_2549701	0.37	LFNG	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	2606	0.23
chr3_182792190_182792488	0.37	MCCC1	methylcrotonoyl-CoA carboxylase 1 (alpha)	24967	0.19
chr14_24783456_24784225	0.37	LTB4R	leukotriene B4 receptor	66	0.91
chr12_110278481_110278632	0.36	TRPV4	transient receptor potential cation channel, subfamily V, member 4	7344	0.15
chr10_48259069_48259363	0.36	ANXA8	annexin A8	3863	0.17
chr8_103741782_103741933	0.36	ENSG00000266799	.	4090	0.28
chr15_42102101_42102252	0.36	RP11-23P13.4		17877	0.09
chr16_89368420_89368663	0.36	AC137932.5		4277	0.15
chr16_11292647_11292983	0.36	RMI2	RecQ mediated genome instability 2	50691	0.08
chr1_111745643_111746099	0.36	DENND2D	DENN/MADD domain containing 2D	1160	0.35
chr20_3782789_3782940	0.36	CDC25B	cell division cycle 25B	5786	0.13
chr7_128006485_128006636	0.36	PRRT4	proline-rich transmembrane protein 4	4821	0.16
chr14_81894135_81894460	0.36	STON2	stonin 2	549	0.86
chr6_36630670_36630821	0.35	ENSG00000251864	.	9870	0.14
chr16_10711037_10711188	0.35	EMP2	epithelial membrane protein 2	36557	0.13
chr8_146015607_146015758	0.35	RPL8	ribosomal protein L8	1856	0.19
chr2_31476447_31476598	0.35	EHD3	EH-domain containing 3	19319	0.18
chr11_116645513_116645664	0.35	AP006216.10		1483	0.25
chr11_75243357_75243645	0.35	GDPD5	glycerophosphodiester phosphodiesterase domain containing 5	6553	0.15
chr1_233462761_233462977	0.34	MLK4	Mitogen-activated protein kinase kinase kinase MLK4	645	0.79
chr1_9781158_9781391	0.34	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	3147	0.23
chr15_63189996_63190147	0.34	RP11-1069G10.1		13838	0.23
chr17_73841947_73842104	0.34	UNC13D	unc-13 homolog D (C. elegans)	1227	0.25
chr15_101733144_101733684	0.34	CHSY1	chondroitin sulfate synthase 1	58723	0.11
chr4_185601941_185602092	0.34	PRIMPOL	primase and polymerase (DNA-directed)	2585	0.29
chr17_1520967_1521246	0.34	ENSG00000238946	.	1517	0.25
chr9_136858320_136859229	0.34	VAV2	vav 2 guanine nucleotide exchange factor	1048	0.54
chr17_48998396_48998613	0.34	TOB1	transducer of ERBB2, 1	53165	0.1
chr4_1754587_1754779	0.34	TACC3	transforming, acidic coiled-coil containing protein 3	24552	0.13
chr7_58045_58196	0.34	FAM20C	family with sequence similarity 20, member C	134849	0.05
chr7_157145222_157145792	0.34	DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	12992	0.24
chr22_18268291_18268442	0.33	BID	BH3 interacting domain death agonist	10935	0.18
chr5_169950070_169950221	0.33	KCNIP1	Kv channel interacting protein 1	18568	0.21
chr5_176864330_176864481	0.33	PRR7-AS1	PRR7 antisense RNA 1	7073	0.09
chrX_47432713_47432906	0.33	TIMP1	TIMP metallopeptidase inhibitor 1	8903	0.13
chr5_146257186_146257400	0.33	PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	912	0.68
chr15_77286567_77286718	0.33	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	784	0.65
chr1_16277969_16279055	0.33	ZBTB17	zinc finger and BTB domain containing 17	7589	0.15
chr12_69864753_69865036	0.33	FRS2	fibroblast growth factor receptor substrate 2	680	0.74
chr4_74751671_74751822	0.33	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	16625	0.15
chr1_154405311_154405652	0.33	IL6R	interleukin 6 receptor	1648	0.28
chr5_56013223_56013374	0.33	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	98103	0.07
chr20_24914059_24914210	0.33	CST7	cystatin F (leukocystatin)	15732	0.21
chr11_47093587_47093738	0.33	C11orf49	chromosome 11 open reading frame 49	19650	0.17
chr7_27993630_27993781	0.33	JAZF1	JAZF zinc finger 1	37970	0.19
chr19_17907446_17907815	0.33	B3GNT3	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	1664	0.26
chrX_153666332_153666497	0.33	GDI1	GDP dissociation inhibitor 1	1148	0.24
chr14_69441554_69441705	0.32	ACTN1	actinin, alpha 1	2654	0.3
chr12_1780268_1780419	0.32	ENSG00000266043	.	10797	0.19
chr12_111483776_111483927	0.32	CUX2	cut-like homeobox 2	12023	0.23
chr4_177195681_177195832	0.32	ASB5	ankyrin repeat and SOCS box containing 5	2966	0.29
chr14_105433817_105433968	0.32	AHNAK2	AHNAK nucleoprotein 2	10802	0.16
chr11_3216794_3216945	0.32	AC108448.3		6093	0.14
chr5_53968473_53968624	0.32	SNX18	sorting nexin 18	154955	0.04
chr12_52629846_52629997	0.32	KRT7	keratin 7	3023	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.9	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.2	0.6	GO:0010815	bradykinin catabolic process(GO:0010815)
0.2	0.5	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.1	0.3	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.4	GO:0071731	response to nitric oxide(GO:0071731)
0.1	0.3	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1	0.4	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1	0.2	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.1	0.3	GO:0071034	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.1	0.3	GO:0001743	optic placode formation(GO:0001743)
0.1	0.3	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.1	0.3	GO:0034063	stress granule assembly(GO:0034063)
0.1	0.3	GO:0060068	vagina development(GO:0060068)
0.1	0.4	GO:0035095	behavioral response to nicotine(GO:0035095)
0.1	0.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.1	0.3	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.1	0.4	GO:0051642	centrosome localization(GO:0051642)
0.1	0.1	GO:0021819	layer formation in cerebral cortex(GO:0021819)
0.1	0.2	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.1	0.2	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.1	0.2	GO:0071243	cellular response to arsenic-containing substance(GO:0071243)
0.1	0.2	GO:0070669	response to interleukin-2(GO:0070669)
0.1	0.2	GO:0032353	negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.1	0.1	GO:0007097	nuclear migration(GO:0007097)
0.0	0.2	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.3	GO:0036296	response to increased oxygen levels(GO:0036296) response to hyperoxia(GO:0055093)
0.0	0.2	GO:0051873	disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.0	0.2	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812)
0.0	0.2	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.2	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.0	GO:0022030	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.6	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0	0.2	GO:0060539	diaphragm development(GO:0060539)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0	0.2	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.1	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.1	GO:0019605	butyrate metabolic process(GO:0019605)
0.0	0.1	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.2	GO:0090218	positive regulation of lipid kinase activity(GO:0090218)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.1	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.2	GO:0032288	myelin assembly(GO:0032288)
0.0	0.1	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.2	GO:0000266	mitochondrial fission(GO:0000266)
0.0	0.1	GO:0043441	acetoacetic acid biosynthetic process(GO:0043441)
0.0	0.3	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.1	GO:0070977	organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0	0.1	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:1902803	regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0	0.1	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.1	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.2	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.1	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.1	GO:0014832	urinary bladder smooth muscle contraction(GO:0014832)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.1	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.1	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.2	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0	0.1	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.0	GO:0043173	nucleotide salvage(GO:0043173)
0.0	0.1	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0	0.1	GO:0016188	synaptic vesicle maturation(GO:0016188)
0.0	0.1	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0021754	facial nucleus development(GO:0021754)
0.0	0.2	GO:0015884	folic acid transport(GO:0015884)
0.0	0.1	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.3	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.2	GO:0014911	positive regulation of smooth muscle cell migration(GO:0014911)
0.0	0.1	GO:0060897	neural plate anterior/posterior regionalization(GO:0021999) neural plate regionalization(GO:0060897)
0.0	0.1	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0	0.0	GO:0014848	urinary tract smooth muscle contraction(GO:0014848)
0.0	0.2	GO:0046718	viral entry into host cell(GO:0046718)
0.0	0.1	GO:0043249	erythrocyte maturation(GO:0043249)
0.0	0.0	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.0	GO:0003179	heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0050965	detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0	0.0	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0032691	negative regulation of interleukin-1 beta production(GO:0032691)
0.0	0.1	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.2	GO:0031122	cytoplasmic microtubule organization(GO:0031122)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0097502	protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0	0.1	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.0	GO:0042754	negative regulation of circadian sleep/wake cycle, sleep(GO:0042321) negative regulation of circadian rhythm(GO:0042754) negative regulation of behavior(GO:0048521)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.0	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.0	GO:0021860	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.1	GO:0042492	gamma-delta T cell differentiation(GO:0042492)
0.0	0.2	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.0	GO:2000542	negative regulation of gastrulation(GO:2000542)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0034453	microtubule anchoring(GO:0034453)
0.0	0.0	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.1	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.1	GO:0042866	pyruvate biosynthetic process(GO:0042866)
0.0	0.1	GO:0032515	negative regulation of phosphatase activity(GO:0010923) negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.1	GO:0006590	thyroid hormone generation(GO:0006590)
0.0	0.2	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.4	GO:0009267	cellular response to starvation(GO:0009267)
0.0	0.1	GO:0042415	norepinephrine metabolic process(GO:0042415)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.1	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0045714	regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045714)
0.0	0.0	GO:0042320	regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0	0.2	GO:0007143	female meiotic division(GO:0007143)
0.0	0.1	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.0	0.0	GO:0034113	heterotypic cell-cell adhesion(GO:0034113) regulation of heterotypic cell-cell adhesion(GO:0034114)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.3	GO:0007398	ectoderm development(GO:0007398)
0.0	0.0	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.1	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0	0.1	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.1	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.0	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.0	GO:0002227	innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385)
0.0	0.1	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.1	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.0	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.3	GO:0046676	negative regulation of peptide secretion(GO:0002792) negative regulation of insulin secretion(GO:0046676) negative regulation of peptide hormone secretion(GO:0090278)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.0	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.0	0.1	GO:0019511	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0007494	midgut development(GO:0007494)
0.0	0.1	GO:0060055	angiogenesis involved in wound healing(GO:0060055)
0.0	0.1	GO:0045990	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0	0.0	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.1	GO:0019240	protein citrullination(GO:0018101) citrulline biosynthetic process(GO:0019240)
0.0	0.1	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.4	GO:0006691	leukotriene metabolic process(GO:0006691)
0.0	0.1	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.0	0.1	GO:0046337	phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.1	GO:0043545	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:0075713	establishment of viral latency(GO:0019043) establishment of integrated proviral latency(GO:0075713)
0.0	0.0	GO:0046471	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.0	GO:0032823	regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0006621	protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0	0.1	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.1	GO:0016115	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.0	GO:0070572	positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0	0.2	GO:0001914	regulation of T cell mediated cytotoxicity(GO:0001914)
0.0	0.1	GO:0030252	growth hormone secretion(GO:0030252)
0.0	0.1	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.1	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.0	0.0	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.0	GO:0050917	sensory perception of umami taste(GO:0050917)
0.0	0.1	GO:0009629	response to gravity(GO:0009629)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:0042117	monocyte activation(GO:0042117)
0.0	0.1	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.0	GO:0045007	depurination(GO:0045007)
0.0	0.2	GO:0051205	protein insertion into membrane(GO:0051205)
0.0	0.2	GO:0006359	regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0	0.0	GO:0000966	RNA 5'-end processing(GO:0000966)
0.0	0.1	GO:0045109	intermediate filament organization(GO:0045109)
0.0	0.0	GO:0021548	pons development(GO:0021548)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.0	GO:0014742	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0	0.1	GO:0048265	response to pain(GO:0048265)
0.0	0.0	GO:0032328	alanine transport(GO:0032328)
0.0	0.0	GO:0017014	protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.0	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.0	GO:0010224	response to UV-B(GO:0010224)
0.0	0.1	GO:0009180	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.2	GO:0031102	neuron projection regeneration(GO:0031102)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.2	GO:0006086	acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.0	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.0	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0060678	dichotomous subdivision of terminal units involved in ureteric bud branching(GO:0060678)
0.0	0.4	GO:0051149	positive regulation of muscle cell differentiation(GO:0051149)
0.0	0.0	GO:0018126	protein hydroxylation(GO:0018126)
0.0	0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.0	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.1	GO:0045214	sarcomere organization(GO:0045214)
0.0	0.1	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.1	GO:0098876	Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0	0.0	GO:0071503	response to heparin(GO:0071503)
0.0	0.0	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0006558	L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0	0.0	GO:0045618	positive regulation of keratinocyte differentiation(GO:0045618)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:0048240	sperm capacitation(GO:0048240)
0.0	0.0	GO:0090037	regulation of protein kinase C signaling(GO:0090036) positive regulation of protein kinase C signaling(GO:0090037)
0.0	0.0	GO:0032495	response to muramyl dipeptide(GO:0032495)
0.0	0.1	GO:0046500	S-adenosylmethionine metabolic process(GO:0046500)
0.0	0.1	GO:0046689	response to mercury ion(GO:0046689)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.0	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.1	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.1	GO:0030225	macrophage differentiation(GO:0030225)
0.0	0.0	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0045040	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.0	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.0	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.0	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.0	GO:0048289	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.0	GO:0006285	base-excision repair, AP site formation(GO:0006285)
0.0	0.1	GO:0042401	cellular biogenic amine biosynthetic process(GO:0042401)
0.0	0.0	GO:0060317	cardiac epithelial to mesenchymal transition(GO:0060317)
0.0	0.2	GO:0001522	pseudouridine synthesis(GO:0001522)
0.0	0.2	GO:0006692	prostanoid metabolic process(GO:0006692)
0.0	0.0	GO:0001866	NK T cell proliferation(GO:0001866) NK T cell activation(GO:0051132)
0.0	0.5	GO:0050434	positive regulation of viral transcription(GO:0050434)
0.0	0.2	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	0.0	GO:0048840	otolith development(GO:0048840)
0.0	0.0	GO:0031659	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0019336	phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0	0.1	GO:0010890	positive regulation of sequestering of triglyceride(GO:0010890)
0.0	0.1	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.0	0.1	GO:0071459	protein localization to chromosome, centromeric region(GO:0071459)
0.0	0.2	GO:0006298	mismatch repair(GO:0006298)
0.0	0.2	GO:0050771	negative regulation of axonogenesis(GO:0050771)
0.0	0.0	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.1	GO:0040020	regulation of meiotic nuclear division(GO:0040020)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.1	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003337) mesenchymal to epithelial transition(GO:0060231) metanephric renal vesicle morphogenesis(GO:0072283)
0.0	0.0	GO:0051882	mitochondrial depolarization(GO:0051882)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.1	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.0	GO:0044803	multi-organism membrane organization(GO:0044803)
0.0	0.0	GO:0019856	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0	0.0	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.0	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.0	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.1	GO:0019682	pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0	0.0	GO:0036473	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.0	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:1903846	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0	0.2	GO:0035303	regulation of dephosphorylation(GO:0035303)
0.0	0.0	GO:0003230	cardiac atrium morphogenesis(GO:0003209) cardiac atrium development(GO:0003230)
0.0	0.1	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0032449	CBM complex(GO:0032449)
0.1	0.3	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.1	0.3	GO:0043218	compact myelin(GO:0043218)
0.1	0.3	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	0.2	GO:0033646	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1	0.3	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1	0.2	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.2	GO:0060203	clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0	0.3	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.3	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.1	GO:0005593	FACIT collagen trimer(GO:0005593)
0.0	0.6	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.2	GO:0042581	specific granule(GO:0042581)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.5	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.1	GO:0002178	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0033185	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.5	GO:0005922	connexon complex(GO:0005922)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.1	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0070552	BRISC complex(GO:0070552)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.4	GO:0008023	transcription elongation factor complex(GO:0008023)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.5	GO:0042641	actomyosin(GO:0042641)
0.0	0.1	GO:0051233	spindle midzone(GO:0051233)
0.0	0.4	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	0.0	GO:0070938	contractile ring(GO:0070938)
0.0	0.1	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.0	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.0	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.2	GO:0071565	nBAF complex(GO:0071565)
0.0	0.2	GO:0046930	pore complex(GO:0046930)
0.0	0.1	GO:0000800	lateral element(GO:0000800)
0.0	0.3	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.4	GO:0016592	mediator complex(GO:0016592)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.0	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.2	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	0.3	GO:0008287	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.0	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.0	0.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	0.6	GO:0055037	recycling endosome(GO:0055037)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.3	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	0.0	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0031332	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.0	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.1	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.0	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.7	GO:0000790	nuclear chromatin(GO:0000790)
0.0	0.5	GO:0030496	midbody(GO:0030496)
0.0	0.1	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.1	GO:0043209	myelin sheath(GO:0043209)
0.0	0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0002080	acrosomal membrane(GO:0002080)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.9	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1	0.4	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	0.5	GO:0051400	BH domain binding(GO:0051400)
0.1	0.3	GO:0004974	leukotriene receptor activity(GO:0004974)
0.1	0.1	GO:0008518	reduced folate carrier activity(GO:0008518)
0.1	0.4	GO:0019211	phosphatase activator activity(GO:0019211)
0.1	0.2	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1	0.2	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.1	0.3	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1	0.2	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1	0.2	GO:0008420	CTD phosphatase activity(GO:0008420)
0.1	0.3	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.1	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.3	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.1	0.2	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.1	0.2	GO:0046980	tapasin binding(GO:0046980)
0.1	0.2	GO:0046923	ER retention sequence binding(GO:0046923)
0.1	0.4	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.1	0.2	GO:0050693	LBD domain binding(GO:0050693)
0.1	0.2	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.2	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.3	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.2	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.2	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.6	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.4	GO:0042166	acetylcholine binding(GO:0042166)
0.0	0.2	GO:0015168	glycerol transmembrane transporter activity(GO:0015168)
0.0	0.1	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.3	GO:0016944	obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.2	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.4	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.2	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.2	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.1	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.3	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.2	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.4	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.5	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.2	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.2	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.5	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.6	GO:0017046	peptide hormone binding(GO:0017046)
0.0	0.0	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.2	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.0	GO:0003964	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.3	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.5	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.0	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.3	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	0.1	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.1	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.0	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.2	GO:0042162	telomeric DNA binding(GO:0042162)
0.0	0.1	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.1	GO:0019863	IgE binding(GO:0019863)
0.0	0.2	GO:0043176	amine binding(GO:0043176)
0.0	0.1	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.3	GO:0004532	exoribonuclease activity(GO:0004532)
0.0	0.0	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0043295	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0015333	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.1	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.1	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.1	GO:0097506	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0	0.0	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.2	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.0	GO:0019798	procollagen-proline dioxygenase activity(GO:0019798)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.2	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.0	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0015556	C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0	0.0	GO:0034648	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.2	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.0	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.2	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.1	GO:0046965	retinoid X receptor binding(GO:0046965)
0.0	0.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0032395	MHC class II receptor activity(GO:0032395)
0.0	0.0	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.1	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.3	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.0	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.0	GO:0031014	troponin T binding(GO:0031014)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.2	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.2	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.2	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.0	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.0	GO:0016803	ether hydrolase activity(GO:0016803)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.0	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.3	GO:0008378	galactosyltransferase activity(GO:0008378)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.0	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.0	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.3	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.3	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.0	GO:0070513	death domain binding(GO:0070513)
0.0	0.0	GO:0046848	hydroxyapatite binding(GO:0046848)
0.0	0.1	GO:0005542	folic acid binding(GO:0005542)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0016847	1-aminocyclopropane-1-carboxylate synthase activity(GO:0016847)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.0	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.0	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.0	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0	0.1	GO:0031078	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.0	GO:0018685	alkane 1-monooxygenase activity(GO:0018685)
0.0	0.0	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.0	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.0	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.1	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.0	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.6	GO:0005178	integrin binding(GO:0005178)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.4	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.4	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.9	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	1.1	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	0.4	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.6	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.4	PID EPO PATHWAY	EPO signaling pathway
0.0	0.7	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	0.2	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.1	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.0	0.7	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.5	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.0	0.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.2	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	0.3	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.0	0.4	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.2	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
0.0	0.2	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.3	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	0.2	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.2	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.4	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	0.3	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.4	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.1	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.0	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.1	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.2	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.0	0.6	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	1.3	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.1	REACTOME HEMOSTASIS	Genes involved in Hemostasis
0.0	0.6	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.5	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	0.5	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.3	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	0.0	REACTOME SIGNALING BY FGFR IN DISEASE	Genes involved in Signaling by FGFR in disease
0.0	0.4	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.4	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.3	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.1	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.5	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.0	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0	0.0	REACTOME PLATELET AGGREGATION PLUG FORMATION	Genes involved in Platelet Aggregation (Plug Formation)
0.0	0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.5	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.2	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.2	REACTOME PROLONGED ERK ACTIVATION EVENTS	Genes involved in Prolonged ERK activation events
0.0	0.2	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.1	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.0	0.2	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.2	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.2	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0	0.0	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.1	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.6	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.2	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0	0.4	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.0	0.0	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.0	0.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.2	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.1	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.1	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	0.3	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.1	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.0	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0	0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.1	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.1	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.2	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.1	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.1	REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.0	0.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.1	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins

Results for KLF1

Z-value: 2.06

Motif logo

Transcription factors associated with KLF1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the KLF1 motif across conditions

Conditions sorted by the z-value of the KLF1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: