Project
ENCODE: H3K4me1 ChIP-Seq of primary human cells
Navigation
Downloads
Results for LEF1
Z-value: 2.73
Motif logo
Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:
This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.
For each TF, only the top 5 correlated CREs are shown.
| CRE | Gene | Distance | Association probability | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|---|---|
| chr4_109027301_109027793 | LEF1 | 59910 | 0.118386 | 0.96 | 4.2e-05 | Click! |
| chr4_109029927_109030290 | LEF1 | 57349 | 0.123695 | 0.97 | 2.1e-05 | Click! |
| chr4_109044873_109045024 | LEF1 | 42509 | 0.157348 | 0.98 | 2.5e-06 | Click! |
| chr4_109055473_109055665 | LEF1 | 31888 | 0.182664 | 0.96 | 3.9e-05 | Click! |
| chr4_109057827_109057978 | LEF1 | 29555 | 0.188088 | 0.96 | 3.0e-05 | Click! |
Showing 1 to 5 of 5 entries
Top target CREs of the motif:
| Cis Regulatory Element (CRE) | Target Score | Top associated gene | Gene Info | Distance of CRE to TSS | CRE/Gene association probability |
|---|---|---|---|---|---|
| chr5_39163244_39163586 | 0.98 |
FYB |
FYN binding protein |
39714 |
0.18 |
| chr12_95383197_95383469 | 0.91 |
NDUFA12 |
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 |
14143 |
0.23 |
| chr7_37349133_37349657 | 0.87 |
ELMO1 |
engulfment and cell motility 1 |
32972 |
0.18 |
| chr19_10254387_10254800 | 0.76 |
EIF3G |
eukaryotic translation initiation factor 3, subunit G |
24015 |
0.07 |
| chr3_32344273_32344503 | 0.75 |
ENSG00000207857 |
. |
43168 |
0.14 |
| chr1_198503645_198504115 | 0.69 |
ATP6V1G3 |
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 |
5924 |
0.32 |
| chr13_114912317_114912766 | 0.69 |
RASA3 |
RAS p21 protein activator 3 |
14455 |
0.21 |
| chr11_128653079_128653231 | 0.68 |
FLI1 |
Fli-1 proto-oncogene, ETS transcription factor |
18470 |
0.2 |
| chr13_114914753_114915138 | 0.67 |
RASA3 |
RAS p21 protein activator 3 |
16859 |
0.2 |
| chr4_109029927_109030290 | 0.67 |
LEF1 |
lymphoid enhancer-binding factor 1 |
57349 |
0.12 |
Histogram of CRE-TSS distances for CREs targeted by :
Rank distribution of CRE target scores:
Distribution of target CREs across different genomic regions:
Network of associatons between targets according to the STRING database.
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.1 | 2.4 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.2 | 2.3 | GO:0043368 | positive T cell selection(GO:0043368) |
| 0.5 | 2.1 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.0 | 2.0 | GO:0018196 | peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 1.8 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.2 | 1.6 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.0 | 1.6 | GO:0000084 | mitotic S phase(GO:0000084) |
| 0.0 | 1.6 | GO:0006397 | mRNA processing(GO:0006397) |
| 0.2 | 1.5 | GO:0045066 | regulatory T cell differentiation(GO:0045066) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.1 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 3.7 | GO:0005768 | endosome(GO:0005768) |
| 0.0 | 2.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 2.3 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 2.2 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 2.1 | GO:0005626 | obsolete insoluble fraction(GO:0005626) |
| 0.0 | 2.0 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 1.9 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 1.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 1.6 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.7 | GO:0003723 | RNA binding(GO:0003723) |
| 0.1 | 3.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 3.0 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 2.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.3 | 2.5 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.1 | 2.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 2.4 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.0 | 2.4 | GO:0016563 | obsolete transcription activator activity(GO:0016563) |
| 0.0 | 2.4 | GO:0060589 | nucleoside-triphosphatase regulator activity(GO:0060589) |
| 0.1 | 2.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.2 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 3.5 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 2.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 2.4 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 2.1 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 2.0 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 1.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 1.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 1.7 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 1.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.6 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 2.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 2.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 2.5 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 2.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 2.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 2.1 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 2.0 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 2.0 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.0 | 2.0 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |