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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for LHX3

Z-value: 1.16

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Transcription factors associated with LHX3

Gene Symbol	Gene ID	Gene Info
LHX3 Ensembl NCBI GeneCards UniProt	ENSG00000107187.11	LHX3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
LHX3	chr9_139098395_139098546	1515	0.385643	0.43	2.5e-01	Click!
LHX3	chr9_139090141_139090292	4788	0.206786	-0.38	3.2e-01	Click!
LHX3	chr9_139084589_139084740	10340	0.182530	-0.37	3.3e-01	Click!
LHX3	chr9_139081692_139081843	13237	0.177542	0.33	3.8e-01	Click!
LHX3	chr9_139085334_139085485	9595	0.184074	-0.29	4.5e-01	Click!

Activity of the LHX3 motif across conditions

Conditions sorted by the z-value of the LHX3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_177651530_177651798	0.83	ENSG00000199858	.	73903	0.13
chr2_161232105_161232912	0.64	ENSG00000252465	.	20971	0.19
chr1_109912007_109912390	0.61	SORT1	sortilin 1	23781	0.14
chr1_67397953_67399117	0.61	MIER1	mesoderm induction early response 1, transcriptional regulator	2609	0.29
chr3_182992678_182993398	0.61	B3GNT5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	9906	0.2
chr7_40621099_40621486	0.58	AC004988.1		34765	0.24
chr2_193011022_193011173	0.57	TMEFF2	transmembrane protein with EGF-like and two follistatin-like domains 2	48153	0.19
chr9_93557837_93558119	0.54	SYK	spleen tyrosine kinase	6091	0.34
chr6_144587139_144587431	0.54	UTRN	utrophin	19552	0.24
chr4_53966535_53966686	0.54	RP11-752D24.2		154754	0.04
chr9_90215657_90216062	0.53	DAPK1-IT1	DAPK1 intronic transcript 1 (non-protein coding)	47490	0.16
chr2_153277819_153278036	0.52	FMNL2	formin-like 2	86176	0.1
chr8_108506998_108507182	0.51	ANGPT1	angiopoietin 1	133	0.98
chr7_81303437_81303728	0.51	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	88730	0.1
chr9_79065617_79065768	0.51	GCNT1	glucosaminyl (N-acetyl) transferase 1, core 2	8376	0.27
chr22_33108393_33108637	0.51	LL22NC01-116C6.1		70648	0.1
chr7_95239146_95239504	0.49	AC002451.3		217	0.94
chr7_102532081_102532232	0.49	LRRC17	leucine rich repeat containing 17	21282	0.16
chr1_222341096_222341247	0.49	ENSG00000212094	.	154739	0.04
chr11_111848937_111849153	0.49	DIXDC1	DIX domain containing 1	1012	0.41
chr6_12266277_12266506	0.49	EDN1	endothelin 1	24205	0.26
chr12_81256633_81256894	0.48	LIN7A	lin-7 homolog A (C. elegans)	26364	0.17
chr10_31053149_31053377	0.48	SVILP1	supervillin pseudogene 1	68413	0.11
chr5_158127271_158127455	0.47	CTD-2363C16.1		282651	0.01
chr15_59641636_59642058	0.47	ENSG00000199512	.	8231	0.13
chr12_90127026_90127233	0.47	ENSG00000252207	.	6416	0.21
chr20_4046539_4046763	0.46	RP11-352D3.2	Uncharacterized protein	9161	0.22
chr6_114196551_114196945	0.44	MARCKS	myristoylated alanine-rich protein kinase C substrate	18207	0.17
chr6_17933009_17933323	0.44	KIF13A	kinesin family member 13A	54528	0.15
chr11_122002800_122002951	0.43	ENSG00000198975	.	14426	0.14
chr12_27430347_27430721	0.42	STK38L	serine/threonine kinase 38 like	16027	0.23
chr3_55558379_55558651	0.42	WNT5A	wingless-type MMTV integration site family, member 5A	34542	0.2
chr4_47215322_47215473	0.42	ENSG00000238301	.	92657	0.09
chr6_52425530_52425681	0.42	TRAM2	translocation associated membrane protein 2	16108	0.24
chr3_149058191_149058568	0.42	TM4SF18	transmembrane 4 L six family member 18	6178	0.2
chr10_90411662_90411938	0.41	LIPF	lipase, gastric	12398	0.19
chr14_69555636_69555913	0.41	ENSG00000206768	.	54896	0.12
chr2_100218822_100218973	0.41	AFF3	AF4/FMR2 family, member 3	24065	0.23
chr1_172248149_172248300	0.41	ENSG00000252354	.	69059	0.1
chr4_141866091_141866242	0.41	RNF150	ring finger protein 150	52024	0.17
chr5_14399490_14399641	0.41	TRIO	trio Rho guanine nucleotide exchange factor	88992	0.1
chr18_10142397_10142548	0.41	ENSG00000263630	.	137278	0.05
chr4_186196562_186196713	0.40	SNX25	sorting nexin 25	65404	0.09
chr20_50543676_50543832	0.40	ENSG00000263659	.	13618	0.19
chr8_108325074_108325225	0.40	ANGPT1	angiopoietin 1	23601	0.25
chr3_125019965_125020116	0.40	SLC12A8	solute carrier family 12, member 8	22019	0.2
chr4_24553435_24554115	0.39	ENSG00000243005	.	11309	0.21
chr2_192121899_192122050	0.39	MYO1B	myosin IB	5751	0.29
chr3_154604594_154604879	0.39	MME	membrane metallo-endopeptidase	137177	0.05
chr3_136505593_136506225	0.39	SLC35G2	solute carrier family 35, member G2	31952	0.12
chr2_27905704_27905855	0.39	SUPT7L	suppressor of Ty 7 (S. cerevisiae)-like	19103	0.11
chr3_12235410_12235692	0.39	TIMP4	TIMP metallopeptidase inhibitor 4	34700	0.2
chr4_38986506_38986933	0.39	TMEM156	transmembrane protein 156	47322	0.13
chr12_65674928_65675079	0.39	RP11-305O6.3		434	0.84
chr3_60921706_60921857	0.39	ENSG00000212211	.	79504	0.12
chr8_58980536_58980687	0.39	FAM110B	family with sequence similarity 110, member B	73498	0.13
chr10_93221945_93222246	0.38	HECTD2	HECT domain containing E3 ubiquitin protein ligase 2	198	0.97
chr1_44966238_44966535	0.38	ENSG00000263381	.	44779	0.13
chr7_137276747_137277035	0.38	PTN	pleiotrophin	248280	0.02
chr7_42233492_42233928	0.38	GLI3	GLI family zinc finger 3	33610	0.25
chr6_3140070_3140221	0.38	BPHL	biphenyl hydrolase-like (serine hydrolase)	514	0.72
chr5_142253906_142254057	0.38	ARHGAP26-AS1	ARHGAP26 antisense RNA 1	5494	0.28
chr11_3980211_3980997	0.38	STIM1	stromal interaction molecule 1	12031	0.18
chrX_134122511_134122662	0.38	SMIM10	small integral membrane protein 10	2382	0.26
chr1_87801300_87801913	0.38	LMO4	LIM domain only 4	4255	0.35
chr6_140892392_140892543	0.38	ENSG00000221336	.	89383	0.1
chr1_95009721_95009872	0.37	F3	coagulation factor III (thromboplastin, tissue factor)	2440	0.41
chr9_130302299_130302610	0.37	FAM129B	family with sequence similarity 129, member B	28913	0.13
chr2_46325558_46325709	0.37	AC017006.2		19666	0.24
chr9_14251921_14252072	0.37	NFIB	nuclear factor I/B	56016	0.15
chr4_86713976_86714229	0.37	ARHGAP24	Rho GTPase activating protein 24	14243	0.26
chr13_33766329_33766480	0.37	STARD13	StAR-related lipid transfer (START) domain containing 13	6188	0.24
chr6_39772853_39773004	0.37	DAAM2	dishevelled associated activator of morphogenesis 2	12134	0.26
chr16_53809610_53810340	0.37	FTO	fat mass and obesity associated	71881	0.11
chr6_56591218_56591369	0.37	DST	dystonin	59384	0.15
chr6_36403738_36403889	0.36	KCTD20	potassium channel tetramerization domain containing 20	6731	0.14
chr4_125335710_125335861	0.36	ANKRD50	ankyrin repeat domain 50	298102	0.01
chr1_55699646_55699797	0.36	ENSG00000265822	.	8407	0.23
chr4_2869241_2869562	0.36	ADD1	adducin 1 (alpha)	8222	0.19
chr1_152022964_152023546	0.36	S100A11	S100 calcium binding protein A11	13744	0.14
chr3_99500056_99500207	0.36	CMSS1	cms1 ribosomal small subunit homolog (yeast)	36547	0.18
chr2_153441109_153441260	0.36	FMNL2	formin-like 2	34908	0.22
chr8_80274236_80274387	0.35	STMN2	stathmin-like 2	248738	0.02
chr7_82224652_82224988	0.35	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	151706	0.05
chr3_152745972_152746123	0.35	RP11-529G21.2		133517	0.05
chr8_128937773_128937924	0.35	TMEM75	transmembrane protein 75	22743	0.19
chr16_69255951_69256102	0.35	RP11-70O5.2		18426	0.12
chr4_111029289_111029440	0.35	ENSG00000263940	.	9528	0.26
chr10_59804431_59804582	0.35	ENSG00000238970	.	194015	0.03
chr3_188995375_188995558	0.35	TPRG1-AS2	TPRG1 antisense RNA 2	37083	0.21
chr5_167097874_167098025	0.35	CTB-78F1.1		10463	0.25
chr13_41627976_41628416	0.35	WBP4	WW domain binding protein 4	7214	0.17
chr5_52627031_52627182	0.34	FST	follistatin	149133	0.04
chr17_35567851_35568148	0.34	ACACA	acetyl-CoA carboxylase alpha	5273	0.28
chr9_91346743_91346894	0.34	ENSG00000265873	.	14002	0.29
chr12_27779794_27779945	0.34	PPFIBP1	PTPRF interacting protein, binding protein 1 (liprin beta 1)	27588	0.17
chr10_16952291_16952577	0.34	CUBN	cubilin (intrinsic factor-cobalamin receptor)	73760	0.11
chr17_61351351_61351502	0.34	RP11-269G24.2		39456	0.15
chr10_95235571_95235788	0.34	MYOF	myoferlin	6272	0.2
chr3_24407013_24407164	0.34	THRB-IT1	THRB intronic transcript 1 (non-protein coding)	93837	0.08
chr3_188560859_188561010	0.34	TPRG1	tumor protein p63 regulated 1	104069	0.08
chr7_36487948_36488099	0.34	AC006960.7		14609	0.19
chr4_178156273_178156424	0.34	RP11-487E13.1	Uncharacterized protein	13579	0.23
chr12_8309941_8310303	0.34	ZNF705A	zinc finger protein 705A	492	0.74
chr13_52928121_52928272	0.34	ENSG00000199605	.	45943	0.13
chr10_54079967_54080118	0.34	DKK1	dickkopf WNT signaling pathway inhibitor 1	5986	0.26
chr2_216529775_216530114	0.34	ENSG00000212055	.	213698	0.02
chr2_145135578_145135895	0.34	GTDC1	glycosyltransferase-like domain containing 1	45653	0.17
chr14_52122560_52122711	0.34	FRMD6	FERM domain containing 6	3937	0.24
chr2_118804547_118804712	0.34	ENSG00000243510	.	30671	0.13
chr1_183776609_183776992	0.34	RGL1	ral guanine nucleotide dissociation stimulator-like 1	2510	0.36
chr1_178143791_178143942	0.34	RASAL2	RAS protein activator like 2	80590	0.11
chr8_32432955_32433282	0.33	NRG1	neuregulin 1	26873	0.26
chr2_55328902_55329053	0.33	ENSG00000266376	.	6869	0.2
chr13_27159400_27159551	0.33	WASF3	WAS protein family, member 3	27588	0.22
chr3_110132390_110132541	0.33	ENSG00000221206	.	138347	0.05
chr12_124515572_124515723	0.33	ZNF664	zinc finger protein 664	57805	0.07
chr3_98701653_98701804	0.33	ENSG00000207331	.	74425	0.1
chr2_200907594_200907745	0.33	C2orf47	chromosome 2 open reading frame 47	87125	0.08
chr6_147234613_147234825	0.33	STXBP5-AS1	STXBP5 antisense RNA 1	1977	0.49
chr6_126268678_126268829	0.33	HINT3	histidine triad nucleotide binding protein 3	9174	0.18
chr13_24462234_24462908	0.33	C1QTNF9B-AS1	C1QTNF9B antisense RNA 1	457	0.68
chr8_59745127_59745278	0.33	ENSG00000201231	.	18091	0.27
chr2_208123731_208123882	0.33	AC007879.5		4830	0.24
chr8_57806614_57806867	0.33	ENSG00000206975	.	22903	0.26
chr5_124748352_124748503	0.33	ENSG00000222107	.	61603	0.16
chr11_113981742_113981893	0.32	ENSG00000221112	.	24166	0.2
chr3_159542327_159542478	0.32	ENSG00000264146	.	1918	0.3
chr2_114040706_114040961	0.32	PAX8	paired box 8	4306	0.2
chr15_49336349_49337349	0.32	SECISBP2L	SECIS binding protein 2-like	1781	0.28
chr6_158460883_158461210	0.32	SYNJ2	synaptojanin 2	22549	0.18
chr12_18498312_18498592	0.32	PIK3C2G	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	63474	0.15
chr8_93978348_93978807	0.32	TRIQK	triple QxxK/R motif containing	204	0.96
chr5_9888608_9888759	0.32	ENSG00000222054	.	127664	0.05
chr8_96574856_96575007	0.32	ENSG00000202112	.	36411	0.22
chr4_38771269_38771420	0.32	TLR10	toll-like receptor 10	6473	0.17
chr17_20092898_20093141	0.32	SPECC1	sperm antigen with calponin homology and coiled-coil domains 1	15830	0.22
chr19_8605989_8606140	0.31	ENSG00000265528	.	5679	0.12
chr10_78157189_78157340	0.31	RP11-369F10.2		41269	0.18
chr9_133720557_133720776	0.31	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	10213	0.21
chr8_25066500_25066825	0.31	DOCK5	dedicator of cytokinesis 5	24282	0.21
chr6_56588753_56588904	0.31	DST	dystonin	61849	0.14
chrX_12229658_12229809	0.31	ENSG00000206795	.	62488	0.12
chr5_16890159_16890310	0.31	MYO10	myosin X	26402	0.18
chr6_114290051_114291212	0.31	RP3-399L15.3		234	0.87
chr9_3912136_3912287	0.31	GLIS3-AS1	GLIS3 antisense RNA 1	13569	0.25
chr3_69813958_69814283	0.31	MITF	microphthalmia-associated transcription factor	1158	0.56
chr12_52348007_52348213	0.31	ACVR1B	activin A receptor, type IB	946	0.5
chr6_140859760_140859911	0.31	ENSG00000221336	.	122015	0.06
chr3_111521650_111521801	0.31	PHLDB2	pleckstrin homology-like domain, family B, member 2	56302	0.14
chr1_17275864_17276015	0.31	CROCC	ciliary rootlet coiled-coil, rootletin	26689	0.11
chr2_40510156_40510307	0.31	AC007377.1		22084	0.23
chr17_35851980_35852131	0.30	DUSP14	dual specificity phosphatase 14	485	0.81
chr15_57513605_57513971	0.30	TCF12	transcription factor 12	2124	0.42
chr7_38209227_38209494	0.30	STARD3NL	STARD3 N-terminal like	8464	0.31
chr14_61041455_61041606	0.30	ENSG00000253014	.	32255	0.15
chr2_145779005_145779156	0.30	ENSG00000253036	.	313558	0.01
chr4_57909352_57909761	0.30	ENSG00000251703	.	40698	0.11
chr2_225681896_225682047	0.30	DOCK10	dedicator of cytokinesis 10	602	0.85
chr2_75819618_75819769	0.30	EVA1A	eva-1 homolog A (C. elegans)	22845	0.13
chr4_7881276_7881455	0.30	AFAP1	actin filament associated protein 1	7325	0.25
chr12_120131477_120131628	0.30	RP1-127H14.3	Uncharacterized protein	6021	0.18
chr3_72338599_72338998	0.30	ENSG00000212070	.	27219	0.26
chr15_39636633_39636784	0.30	RP11-624L4.1		70624	0.12
chr7_92295493_92295644	0.30	ENSG00000206763	.	35560	0.18
chr4_182984434_182984585	0.30	AC108142.1		21728	0.23
chr6_44414403_44414554	0.30	ENSG00000266619	.	11100	0.18
chr5_52079021_52079172	0.29	ITGA1	integrin, alpha 1	4634	0.21
chr1_101108683_101108834	0.29	VCAM1	vascular cell adhesion molecule 1	76540	0.1
chr1_23610078_23610229	0.29	HNRNPR	heterogeneous nuclear ribonucleoprotein R	60602	0.09
chr4_48942200_48942351	0.29	ENSG00000252913	.	7404	0.21
chr15_70556363_70556608	0.29	ENSG00000200216	.	70910	0.13
chr7_152010807_152011572	0.29	KMT2C	lysine (K)-specific methyltransferase 2C	66085	0.11
chr2_69417973_69418124	0.29	ENSG00000199460	.	8039	0.21
chr2_138722580_138722731	0.29	HNMT	histamine N-methyltransferase	612	0.86
chr1_186426484_186426635	0.29	PDC	phosducin	3695	0.21
chr3_167577259_167577557	0.29	SERPINI1	serpin peptidase inhibitor, clade I (neuroserpin), member 1	52382	0.17
chr8_32573551_32573702	0.29	NRG1	neuregulin 1	5645	0.34
chr9_110573374_110573525	0.29	ENSG00000244104	.	746	0.68
chr7_28002187_28002338	0.29	JAZF1	JAZF zinc finger 1	29413	0.22
chr10_104956679_104957044	0.29	NT5C2	5'-nucleotidase, cytosolic II	3805	0.25
chr4_138229530_138229827	0.29	ENSG00000222526	.	80396	0.12
chrX_39832066_39832217	0.29	BCOR	BCL6 corepressor	90049	0.09
chr12_24383335_24383486	0.29	ENSG00000216192	.	18055	0.3
chr6_128390722_128390873	0.29	PTPRK	protein tyrosine phosphatase, receptor type, K	4889	0.29
chr17_57075608_57075759	0.29	ENSG00000216168	.	9368	0.15
chr9_138861135_138861286	0.29	UBAC1	UBA domain containing 1	7984	0.21
chr9_91389382_91389533	0.29	ENSG00000265873	.	28637	0.25
chr5_163012032_163012183	0.29	MAT2B	methionine adenosyltransferase II, beta	79487	0.09
chr2_69469610_69469761	0.29	ENSG00000199460	.	59676	0.11
chr6_15066355_15066506	0.29	ENSG00000242989	.	46769	0.18
chr15_56617819_56617970	0.28	TEX9	testis expressed 9	39731	0.17
chr12_89698996_89699278	0.28	ENSG00000238302	.	23075	0.22
chr11_75657287_75657506	0.28	ENSG00000223013	.	11416	0.16
chr15_34913517_34913668	0.28	ENSG00000252425	.	23833	0.16
chr2_150601107_150601258	0.28	ENSG00000207270	.	133894	0.05
chr1_88305877_88306028	0.28	ENSG00000199318	.	386896	0.01
chr8_99571908_99572059	0.28	KB-1205A7.2		43498	0.17
chr1_178313576_178313822	0.28	RASAL2	RAS protein activator like 2	3093	0.37
chr16_66604769_66604920	0.28	CMTM1	CKLF-like MARVEL transmembrane domain containing 1	4427	0.11

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.3	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.1	0.3	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.1	0.2	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.2	GO:0030091	protein repair(GO:0030091)
0.1	0.2	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.1	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.1	0.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1	0.3	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.1	0.2	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.1	0.2	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1	0.3	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.1	0.3	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1	0.2	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.1	0.2	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.1	0.1	GO:1903224	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.0	GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.1	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.2	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.2	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.2	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.1	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.1	GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.2	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.2	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.1	GO:0048631	regulation of skeletal muscle tissue growth(GO:0048631)
0.0	0.2	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.2	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.0	GO:0060197	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.1	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.0	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.4	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.1	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.0	GO:0061525	hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.0	0.1	GO:0060754	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.2	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.1	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.1	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:1903170	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.1	GO:0033024	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.1	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.0	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.0	GO:0031392	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.1	GO:0051877	pigment granule aggregation in cell center(GO:0051877)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.0	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:1901722	regulation of cell proliferation involved in kidney development(GO:1901722)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.1	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.1	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.0	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0033860	regulation of NAD(P)H oxidase activity(GO:0033860)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.1	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.3	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.2	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.1	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.3	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.1	GO:0010566	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.4	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.2	GO:0006972	hyperosmotic response(GO:0006972)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.0	GO:0046882	regulation of follicle-stimulating hormone secretion(GO:0046880) negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:0072193	ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.1	GO:2000757	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.0	GO:0016999	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.3	GO:0030032	lamellipodium assembly(GO:0030032)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.0	GO:0070932	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.1	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.0	0.0	GO:0060789	hair follicle placode formation(GO:0060789)
0.0	0.1	GO:0007320	insemination(GO:0007320)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.1	GO:0008655	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.0	GO:0010842	retina layer formation(GO:0010842)
0.0	0.0	GO:0021873	forebrain neuroblast division(GO:0021873)
0.0	0.0	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.0	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.0	0.0	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.0	0.2	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.1	GO:0060612	adipose tissue development(GO:0060612)
0.0	0.0	GO:0018342	protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0	0.0	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0070254	mucus secretion(GO:0070254)
0.0	0.0	GO:0060535	lung growth(GO:0060437) trachea cartilage development(GO:0060534) trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:1902603	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.1	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.0	GO:0051549	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.0	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.0	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.2	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.0	GO:0000966	RNA 5'-end processing(GO:0000966)
0.0	0.1	GO:0046825	regulation of protein export from nucleus(GO:0046825)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.0	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0001958	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0	0.0	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.0	GO:0071680	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0	0.1	GO:0043922	negative regulation by host of viral transcription(GO:0043922)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.1	GO:0007603	phototransduction, visible light(GO:0007603)
0.0	0.0	GO:0010107	potassium ion import(GO:0010107)
0.0	0.0	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.0	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.2	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.2	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0060644	mammary gland epithelial cell differentiation(GO:0060644)
0.0	0.1	GO:0001556	oocyte maturation(GO:0001556)
0.0	0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0048844	artery morphogenesis(GO:0048844)
0.0	0.0	GO:0014041	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.0	GO:0022601	menstrual cycle phase(GO:0022601)
0.0	0.2	GO:0051897	positive regulation of protein kinase B signaling(GO:0051897)
0.0	0.1	GO:0046498	S-adenosylhomocysteine metabolic process(GO:0046498)
0.0	0.0	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0051593	response to folic acid(GO:0051593)
0.0	0.0	GO:0060174	limb bud formation(GO:0060174)
0.0	0.1	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.1	GO:0071675	mononuclear cell migration(GO:0071674) regulation of mononuclear cell migration(GO:0071675)
0.0	0.1	GO:0003156	regulation of organ formation(GO:0003156)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.1	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.0	0.0	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.2	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.2	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.2	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.4	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.2	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.8	GO:0005902	microvillus(GO:0005902)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.0	GO:0044215	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	0.2	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0051233	spindle midzone(GO:0051233)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.1	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.4	GO:0005884	actin filament(GO:0005884)
0.0	0.1	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:0001520	outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0	0.1	GO:0005749	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.0	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.0	GO:0005827	polar microtubule(GO:0005827)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.3	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.1	0.2	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1	0.3	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1	0.2	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.1	0.2	GO:0048495	Roundabout binding(GO:0048495)
0.1	0.2	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	0.3	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.1	0.2	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.1	0.2	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.1	0.3	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1	0.3	GO:0009374	biotin binding(GO:0009374)
0.1	0.2	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	0.3	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.2	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.0	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0008252	nucleotidase activity(GO:0008252)
0.0	0.7	GO:1990782	receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0	0.2	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.3	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.2	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.2	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.2	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.0	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0030343	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.3	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.2	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.1	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.1	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.0	0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.1	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.2	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.2	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.4	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.4	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.1	GO:0016615	malate dehydrogenase activity(GO:0016615)
0.0	0.1	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.0	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.0	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.0	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.0	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.0	GO:0005415	nucleoside:sodium symporter activity(GO:0005415)
0.0	0.2	GO:1905030	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.0	GO:0004803	transposase activity(GO:0004803)
0.0	0.0	GO:0048039	ubiquinone binding(GO:0048039)
0.0	0.0	GO:0034648	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.1	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0	0.1	GO:0004551	nucleotide diphosphatase activity(GO:0004551)
0.0	0.1	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.0	0.0	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.2	GO:0070566	adenylyltransferase activity(GO:0070566)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.0	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.0	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.0	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.0	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.0	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.0	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.0	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.0	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0005536	glucose binding(GO:0005536)
0.0	0.1	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0004945	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.0	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.0	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.0	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.1	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.1	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.0	GO:0000104	succinate dehydrogenase activity(GO:0000104)
0.0	0.1	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0016406	carnitine O-acyltransferase activity(GO:0016406)
0.0	0.1	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.0	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.0	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.4	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.3	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.8	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.1	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.4	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.7	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.3	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.7	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS	Genes involved in Synthesis of bile acids and bile salts
0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.2	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.3	REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	Genes involved in Integrin alphaIIb beta3 signaling
0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)