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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for LHX8

Z-value: 1.48

Motif logo

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Transcription factors associated with LHX8

Gene Symbol Gene ID Gene Info
LHX8
ENSG00000162624.10 LHX8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
LHX8chr1_75600824_756009963430.839693-0.853.6e-03Click!
LHX8chr1_75600579_75600730870.957213-0.781.3e-02Click!
LHX8chr1_75601220_756014587720.585136-0.752.0e-02Click!
LHX8chr1_75601640_7560179111480.437031-0.422.6e-01Click!
LHX8chr1_75430278_754304291637660.033665-0.284.7e-01Click!

Activity of the LHX8 motif across conditions

Conditions sorted by the z-value of the LHX8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr3_171547228_171547513 0.44 TMEM212
 transmembrane protein 212
 13769
 0.18
chr6_35588984_35589141 0.39 ENSG00000212579
 .
 30533
 0.14
chr7_132524694_132524845 0.37 AC009518.8
9316
 0.27
chr5_118718463_118718642 0.34 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 26822
 0.17
chr2_224800348_224800499 0.33 WDFY1
 WD repeat and FYVE domain containing 1
 9651
 0.2
chr12_110816955_110817106 0.33 ANAPC7
 anaphase promoting complex subunit 7
 2633
 0.23
chr10_95734237_95734388 0.32 PLCE1
 phospholipase C, epsilon 1
 19434
 0.21
chr4_100863849_100864145 0.32 DNAJB14
 DnaJ (Hsp40) homolog, subfamily B, member 14
 3886
 0.2
chr5_74798216_74798367 0.31 COL4A3BP
 collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
 9163
 0.19
chr20_43646840_43647043 0.31 ENSG00000252021
 .
 13952
 0.16
chr1_202125548_202126022 0.30 PTPN7
 protein tyrosine phosphatase, non-receptor type 7
 3334
 0.18
chr3_137935329_137935480 0.30 ARMC8
 armadillo repeat containing 8
 7074
 0.23
chr22_17597863_17598182 0.30 CECR6
 cat eye syndrome chromosome region, candidate 6
 4121
 0.17
chr3_5029460_5029611 0.30 BHLHE40-AS1
 BHLHE40 antisense RNA 1
 7889
 0.21
chr2_42331828_42332250 0.30 PKDCC
 protein kinase domain containing, cytoplasmic
 56879
 0.12
chr12_46018307_46018458 0.30 ENSG00000239178
 .
 69940
 0.13
chrX_11784442_11784722 0.29 MSL3
 male-specific lethal 3 homolog (Drosophila)
 6835
 0.32
chr9_88953538_88953925 0.29 ZCCHC6
 zinc finger, CCHC domain containing 6
 4307
 0.27
chr6_130509586_130509737 0.29 SAMD3
 sterile alpha motif domain containing 3
 26774
 0.22
chr19_17505749_17506030 0.28 BST2
 bone marrow stromal cell antigen 2
 10568
 0.08
chr4_101961643_101961893 0.28 EMCN-IT1
 EMCN intronic transcript 1 (non-protein coding)
 226331
 0.02
chr5_132393541_132393692 0.28 HSPA4
 heat shock 70kDa protein 4
 5962
 0.2
chr1_198158796_198158947 0.28 NEK7
 NIMA-related kinase 7
 17133
 0.3
chr4_106087217_106087368 0.28 TET2-AS1
 TET2 antisense RNA 1
 11928
 0.21
chr9_101882526_101882813 0.28 TGFBR1
 transforming growth factor, beta receptor 1
 7388
 0.21
chr5_100043082_100043233 0.27 ENSG00000207269
 .
 25605
 0.25
chr2_114664564_114664715 0.27 ACTR3
 ARP3 actin-related protein 3 homolog (yeast)
 16464
 0.22
chr8_104117881_104118032 0.27 ENSG00000265667
 .
 13007
 0.13
chr1_159045897_159046203 0.27 AIM2
 absent in melanoma 2
 641
 0.71
chr3_2951081_2951232 0.27 CNTN4
 contactin 4
 8761
 0.3
chr12_69041617_69041845 0.26 ENSG00000206650
 .
 20576
 0.18
chr14_59812487_59812638 0.26 ENSG00000252869
 .
 54179
 0.14
chr18_9793644_9793795 0.26 ENSG00000242651
 .
 36905
 0.15
chr11_86661115_86661399 0.26 FZD4
 frizzled family receptor 4
 5176
 0.26
chr21_23086135_23086286 0.26 ENSG00000221210
 .
 316064
 0.01
chr11_109945056_109945207 0.26 ZC3H12C
 zinc finger CCCH-type containing 12C
 18956
 0.29
chr1_98368422_98368711 0.26 DPYD
 dihydropyrimidine dehydrogenase
 17987
 0.28
chr2_144031553_144031826 0.25 RP11-190J23.1
101948
 0.08
chr6_11365715_11365866 0.25 NEDD9
 neural precursor cell expressed, developmentally down-regulated 9
 16742
 0.26
chr22_37677600_37677751 0.25 CYTH4
 cytohesin 4
 393
 0.83
chr11_77050584_77050735 0.25 PAK1
 p21 protein (Cdc42/Rac)-activated kinase 1
 9673
 0.24
chr13_74288455_74288993 0.25 KLF12
 Kruppel-like factor 12
 280462
 0.01
chr2_118854222_118854373 0.25 INSIG2
 insulin induced gene 2
 8247
 0.24
chr10_22906078_22906308 0.25 PIP4K2A
 phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
 25551
 0.25
chr18_2687837_2688110 0.25 SMCHD1
 structural maintenance of chromosomes flexible hinge domain containing 1
 32087
 0.13
chr4_15644909_15645060 0.25 FBXL5
 F-box and leucine-rich repeat protein 5
 1288
 0.49
chr1_114393658_114393809 0.25 AP4B1-AS1
 AP4B1 antisense RNA 1
 5524
 0.14
chr6_16687204_16687395 0.25 RP1-151F17.1
74070
 0.11
chr3_107802086_107802279 0.25 CD47
 CD47 molecule
 7679
 0.31
chr5_114877836_114878017 0.24 FEM1C
 fem-1 homolog c (C. elegans)
 2665
 0.3
chr10_90709918_90710069 0.24 ACTA2
 actin, alpha 2, smooth muscle, aorta
 2537
 0.23
chr9_86050414_86050565 0.24 ENSG00000238608
 .
 16699
 0.21
chr2_46665689_46665843 0.24 ENSG00000241791
 .
 9884
 0.2
chr3_43515210_43515361 0.24 ENSG00000251811
 .
 1316
 0.55
chr10_112720074_112720225 0.24 SHOC2
 soc-2 suppressor of clear homolog (C. elegans)
 4460
 0.19
chr3_81801729_81801880 0.24 GBE1
 glucan (1,4-alpha-), branching enzyme 1
 9024
 0.33
chr6_22366815_22366966 0.24 PRL
 prolactin
 69160
 0.13
chr3_39250957_39251108 0.24 XIRP1
 xin actin-binding repeat containing 1
 16945
 0.19
chr10_77492995_77493165 0.24 RP11-367B6.2
9418
 0.24
chr3_69245956_69246107 0.24 FRMD4B
 FERM domain containing 4B
 2390
 0.37
chr1_12185179_12185361 0.24 TNFRSF8
 tumor necrosis factor receptor superfamily, member 8
 686
 0.66
chr14_78219731_78219882 0.24 C14orf178
 chromosome 14 open reading frame 178
 7367
 0.14
chr2_242285300_242285489 0.24 SEPT2
 septin 2
 4108
 0.17
chr16_58913891_58914042 0.24 ENSG00000244003
 .
 109538
 0.06
chr3_142557847_142557998 0.24 ENSG00000251787
 .
 37873
 0.14
chr9_71399265_71399416 0.24 FAM122A
 family with sequence similarity 122A
 4376
 0.27
chrX_38666948_38667099 0.24 MID1IP1-AS1
 MID1IP1 antisense RNA 1
 3887
 0.27
chr10_121237439_121237906 0.24 RGS10
 regulator of G-protein signaling 10
 49317
 0.14
chr15_59146843_59146994 0.24 RP11-30K9.5
10344
 0.14
chr14_61836268_61836532 0.23 PRKCH
 protein kinase C, eta
 8608
 0.24
chr11_60610377_60610615 0.23 RP11-804A23.2
58
 0.92
chr13_41132128_41132279 0.23 AL133318.1
 Uncharacterized protein
 20880
 0.24
chr6_137081513_137081694 0.23 MAP3K5
 mitogen-activated protein kinase kinase kinase 5
 32053
 0.18
chr12_65090896_65091133 0.23 AC025262.1
 Mesenchymal stem cell protein DSC96; Uncharacterized protein
 685
 0.64
chr9_21024355_21024653 0.23 PTPLAD2
 protein tyrosine phosphatase-like A domain containing 2
 7104
 0.22
chr11_94954464_94954615 0.23 RP11-712B9.2
8811
 0.23
chr4_109031503_109031852 0.23 LEF1
 lymphoid enhancer-binding factor 1
 55780
 0.13
chr2_162229850_162230001 0.23 ENSG00000221590
 .
 23054
 0.15
chr20_33732912_33733126 0.23 EDEM2
 ER degradation enhancer, mannosidase alpha-like 2
 60
 0.96
chr5_60639238_60639389 0.23 ZSWIM6
 zinc finger, SWIM-type containing 6
 11213
 0.29
chrX_17813136_17813287 0.23 RAI2
 retinoic acid induced 2
 42639
 0.18
chr3_113950179_113950372 0.23 ZNF80
 zinc finger protein 80
 6150
 0.18
chr6_12184707_12184858 0.23 HIVEP1
 human immunodeficiency virus type I enhancer binding protein 1
 58803
 0.15
chr20_43657355_43657581 0.23 ENSG00000252021
 .
 24479
 0.14
chr11_3760141_3760292 0.23 NUP98
 nucleoporin 98kDa
 21608
 0.1
chr4_15256524_15256675 0.23 RP11-665G4.1
27015
 0.23
chr3_4949233_4949520 0.22 BHLHE40-AS1
 BHLHE40 antisense RNA 1
 1190
 0.49
chr17_29143963_29144169 0.22 CRLF3
 cytokine receptor-like factor 3
 7623
 0.13
chr9_82247341_82247492 0.22 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
 20092
 0.3
chr1_36015652_36015803 0.22 KIAA0319L
 KIAA0319-like
 4861
 0.17
chr21_38809303_38809462 0.22 DYRK1A
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
 16705
 0.23
chr4_109065027_109065178 0.22 LEF1
 lymphoid enhancer-binding factor 1
 22355
 0.2
chr8_108830160_108830311 0.22 ENSG00000200806
 .
 66487
 0.14
chr20_3972793_3973048 0.22 RNF24
 ring finger protein 24
 17886
 0.19
chr6_129766976_129767127 0.22 ENSG00000252554
 .
 8926
 0.27
chr14_39287950_39288101 0.22 ENSG00000199285
 .
 168460
 0.04
chr12_9805985_9806454 0.22 RP11-705C15.2
60
 0.96
chr2_225443234_225443385 0.22 CUL3
 cullin 3
 6756
 0.33
chr9_129163662_129163813 0.22 ENSG00000253079
 .
 6952
 0.21
chr12_102453949_102454100 0.22 CCDC53
 coiled-coil domain containing 53
 1833
 0.31
chr21_15911267_15911507 0.22 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 7275
 0.26
chr5_142500061_142500271 0.22 ARHGAP26
 Rho GTPase activating protein 26
 64518
 0.13
chr17_46485231_46485382 0.22 SKAP1
 src kinase associated phosphoprotein 1
 22246
 0.12
chr3_131089789_131089940 0.22 NUDT16P1
 nudix (nucleoside diphosphate linked moiety X)-type motif 16 pseudogene 1
 9090
 0.17
chr10_24910488_24910681 0.22 ARHGAP21
 Rho GTPase activating protein 21
 1179
 0.56
chrX_138672209_138672360 0.22 ENSG00000216114
 .
 9178
 0.21
chr4_90232073_90232224 0.22 GPRIN3
 GPRIN family member 3
 2987
 0.4
chrX_48586382_48586533 0.21 ENSG00000206723
 .
 3491
 0.14
chr8_82065263_82065697 0.21 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
 41177
 0.19
chr10_104868083_104868234 0.21 NT5C2
 5'-nucleotidase, cytosolic II
 1751
 0.44
chr4_101961293_101961465 0.21 EMCN-IT1
 EMCN intronic transcript 1 (non-protein coding)
 225942
 0.02
chr4_153738011_153738162 0.21 ARFIP1
 ADP-ribosylation factor interacting protein 1
 36949
 0.16
chrX_47556921_47557072 0.21 CXXC1P1
 CXXC finger protein 1 pseudogene 1
 24734
 0.13
chr11_68504611_68504762 0.21 MTL5
 metallothionein-like 5, testis-specific (tesmin)
 14242
 0.2
chr11_17976069_17976220 0.21 SERGEF
 secretion regulating guanine nucleotide exchange factor
 34160
 0.17
chr15_38902764_38903045 0.21 RASGRP1
 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
 45128
 0.15
chr12_4058973_4059124 0.21 RP11-664D1.1
44662
 0.18
chr10_28338660_28338811 0.21 ARMC4
 armadillo repeat containing 4
 50758
 0.17
chr5_142182149_142182300 0.21 ARHGAP26
 Rho GTPase activating protein 26
 29942
 0.21
chr17_1365840_1366319 0.21 CRK
 v-crk avian sarcoma virus CT10 oncogene homolog
 6527
 0.15
chr8_126657314_126657465 0.21 ENSG00000266452
 .
 200582
 0.03
chr3_114028090_114028374 0.21 ENSG00000207770
 .
 7184
 0.18
chrX_67401924_67402162 0.21 ENSG00000252145
 .
 80069
 0.11
chrX_20229909_20230060 0.21 RPS6KA3
 ribosomal protein S6 kinase, 90kDa, polypeptide 3
 6995
 0.22
chr11_46513342_46513546 0.21 ENSG00000265014
 .
 40005
 0.14
chr8_42000592_42000772 0.21 RP11-589C21.5
9599
 0.17
chr4_106081664_106081815 0.21 TET2
 tet methylcytosine dioxygenase 2
 13125
 0.21
chr12_29318198_29318373 0.21 FAR2
 fatty acyl CoA reductase 2
 16152
 0.24
chr18_29622386_29622822 0.21 ENSG00000265063
 .
 18348
 0.13
chr6_41986819_41986970 0.21 ENSG00000206875
 .
 642
 0.68
chr16_11991411_11991562 0.21 GSPT1
 G1 to S phase transition 1
 252
 0.86
chr2_235367929_235368080 0.21 ARL4C
 ADP-ribosylation factor-like 4C
 37240
 0.23
chr5_17438596_17438747 0.21 ENSG00000201715
 .
 92946
 0.09
chr8_71132477_71132643 0.21 NCOA2
 nuclear receptor coactivator 2
 25050
 0.23
chr7_132979014_132979165 0.21 ENSG00000238844
 .
 31604
 0.21
chr5_169698045_169698343 0.21 LCP2
 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
 3863
 0.27
chr5_142789348_142789499 0.21 NR3C1
 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
 4535
 0.34
chr1_109202283_109202603 0.21 HENMT1
 HEN1 methyltransferase homolog 1 (Arabidopsis)
 1234
 0.47
chr21_39623507_39623658 0.21 KCNJ15
 potassium inwardly-rectifying channel, subfamily J, member 15
 5081
 0.29
chr6_41048012_41048396 0.21 NFYA
 nuclear transcription factor Y, alpha
 7482
 0.13
chr18_72372150_72372301 0.21 ZNF407
 zinc finger protein 407
 29249
 0.24
chr13_74598508_74598659 0.21 KLF12
 Kruppel-like factor 12
 29397
 0.26
chr16_23879975_23880302 0.21 PRKCB
 protein kinase C, beta
 31594
 0.2
chr3_9434517_9434896 0.21 SETD5-AS1
 SETD5 antisense RNA 1
 1200
 0.39
chr3_27575150_27575759 0.21 ENSG00000238912
 .
 13895
 0.2
chr2_181641800_181641951 0.21 ENSG00000264976
 .
 159942
 0.04
chr5_101632941_101633136 0.21 SLCO4C1
 solute carrier organic anion transporter family, member 4C1
 785
 0.67
chr4_4462962_4463617 0.21 STX18
 syntaxin 18
 392
 0.87
chr12_14548937_14549088 0.21 ATF7IP
 activating transcription factor 7 interacting protein
 1215
 0.56
chr9_110897638_110897789 0.21 ENSG00000222459
 .
 216454
 0.02
chr14_97586844_97587256 0.21 VRK1
 vaccinia related kinase 1
 244684
 0.02
chr3_43371875_43372026 0.21 ENSG00000241939
 .
 15507
 0.16
chr10_63944095_63944273 0.20 RTKN2
 rhotekin 2
 51838
 0.15
chr7_139249827_139249978 0.20 CLEC2L
 C-type lectin domain family 2, member L
 41074
 0.17
chr12_30835807_30835958 0.20 IPO8
 importin 8
 5704
 0.3
chr18_2988877_2989028 0.20 LPIN2
 lipin 2
 6081
 0.17
chrX_96026603_96026754 0.20 ENSG00000207426
 .
 70060
 0.12
chrX_73067879_73068030 0.20 RP13-216E22.5
121366
 0.06
chr5_50046144_50046322 0.20 PARP8
 poly (ADP-ribose) polymerase family, member 8
 82842
 0.11
chr3_71447838_71447989 0.20 FOXP1
 forkhead box P1
 94002
 0.08
chr10_111975212_111975532 0.20 MXI1
 MAX interactor 1, dimerization protein
 5383
 0.23
chr20_51990277_51990428 0.20 RP4-669H2.1
39096
 0.17
chr14_95563807_95563958 0.20 DICER1
 dicer 1, ribonuclease type III
 5885
 0.23
chr8_61859867_61860032 0.20 CLVS1
 clavesin 1
 109768
 0.07
chr10_20639964_20640115 0.20 ENSG00000265372
 .
 200860
 0.03
chr4_79322016_79322167 0.20 FRAS1
 Fraser syndrome 1
 18101
 0.28
chr14_23494825_23495047 0.20 ENSG00000207765
 .
 7911
 0.08
chr3_49298618_49298769 0.20 RP11-3B7.1
 Uncharacterized protein
 1175
 0.31
chr3_71820514_71820665 0.20 PROK2
 prokineticin 2
 13623
 0.18
chr2_84879868_84880019 0.20 DNAH6
 dynein, axonemal, heavy chain 6
 5488
 0.31
chr2_208802616_208802767 0.20 PLEKHM3
 pleckstrin homology domain containing, family M, member 3
 39483
 0.14
chr8_103896614_103896765 0.20 KB-1507C5.3
7415
 0.17
chr6_149669103_149669254 0.20 TAB2
 TGF-beta activated kinase 1/MAP3K7 binding protein 2
 21866
 0.18
chr1_224010673_224010824 0.20 TP53BP2
 tumor protein p53 binding protein, 2
 8718
 0.27
chr2_26058872_26059023 0.20 ASXL2
 additional sex combs like 2 (Drosophila)
 42388
 0.17
chr2_136719996_136720195 0.20 AC093391.2
22651
 0.18
chr13_110302972_110303123 0.20 LINC00676
 long intergenic non-protein coding RNA 676
 77582
 0.12
chr12_14557948_14558281 0.20 ATF7IP
 activating transcription factor 7 interacting protein
 3310
 0.31
chr1_40630962_40631113 0.20 RLF
 rearranged L-myc fusion
 3992
 0.2
chr18_21823884_21824035 0.20 ENSG00000206766
 .
 25695
 0.13
chr22_40338171_40338362 0.20 GRAP2
 GRB2-related adaptor protein 2
 4555
 0.2
chr11_9183093_9183244 0.19 DENND5A
 DENN/MADD domain containing 5A
 9214
 0.2
chr10_49537749_49537900 0.19 MAPK8
 mitogen-activated protein kinase 8
 22755
 0.22
chr5_156969848_156970007 0.19 AC106801.1
23045
 0.14
chr7_72482355_72482506 0.19 ENSG00000201282
 .
 765
 0.47
chr5_17453794_17453945 0.19 ENSG00000201715
 .
 108144
 0.07
chr3_29196189_29196340 0.19 RBMS3
 RNA binding motif, single stranded interacting protein 3
 126209
 0.06
chr6_37769563_37769803 0.19 RP3-441A12.1
17311
 0.18
chr15_55533028_55533179 0.19 RAB27A
 RAB27A, member RAS oncogene family
 8130
 0.22
chr17_28194872_28195023 0.19 RP11-338L22.2
4527
 0.17
chr8_73988156_73988307 0.19 RP11-956J14.1
9883
 0.16
chr7_41695372_41695523 0.19 INHBA-AS1
 INHBA antisense RNA 1
 38067
 0.17
chr14_45426633_45426853 0.19 KLHL28
 kelch-like family member 28
 3592
 0.2
chr6_144029827_144029978 0.19 PHACTR2
 phosphatase and actin regulator 2
 30697
 0.21
chr1_111727139_111727290 0.19 RP5-1180E21.5
469
 0.71
chr5_55981642_55982013 0.19 AC022431.2
 Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.
 79768
 0.09
chr9_75205109_75205260 0.19 TMC1
 transmembrane channel-like 1
 24432
 0.24
chr13_30893918_30894069 0.19 KATNAL1
 katanin p60 subunit A-like 1
 12372
 0.24
chr12_96617227_96617404 0.19 RP11-394J1.2
436
 0.85
chr3_156020631_156020782 0.19 KCNAB1
 potassium voltage-gated channel, shaker-related subfamily, beta member 1
 11009
 0.27

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of LHX8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0061299 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.1 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.0 0.1 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.2 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0 0.1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.0 GO:0070669 response to interleukin-2(GO:0070669)
0.0 0.1 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.0 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0032933 SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.1 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.1 GO:0030540 female genitalia development(GO:0030540)
0.0 0.2 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.0 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:1903429 regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0 0.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.1 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0 0.1 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.1 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0051459 corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0 0.1 GO:0042023 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.0 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070)
0.0 0.0 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.0 GO:0021860 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:0043368 positive T cell selection(GO:0043368)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.0 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 0.0 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.0 GO:0090047 obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0 0.1 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.1 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.0 GO:0045341 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:0032733 positive regulation of interleukin-10 production(GO:0032733)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.0 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.1 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.0 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 0.1 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0 0.0 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.0 0.0 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.0 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 0.0 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.0 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.1 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.1 GO:0006911 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.1 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.0 GO:0034776 response to histamine(GO:0034776)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.0 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.0 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.0 GO:0039656 modulation by virus of host gene expression(GO:0039656)
0.0 0.1 GO:0031033 myosin filament organization(GO:0031033)
0.0 0.1 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.1 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.0 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0 0.4 GO:1903038 negative regulation of T cell activation(GO:0050868) negative regulation of leukocyte cell-cell adhesion(GO:1903038)
0.0 0.0 GO:0045060 negative thymic T cell selection(GO:0045060)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.0 GO:0031943 regulation of glucocorticoid metabolic process(GO:0031943)
0.0 0.1 GO:0007141 male meiosis I(GO:0007141)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.0 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.0 0.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.0 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.0 GO:0072216 positive regulation of metanephros development(GO:0072216)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.0 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.0 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.0 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.1 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0 0.0 GO:0046469 platelet activating factor metabolic process(GO:0046469)
0.0 0.0 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.0 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.0 GO:0060437 lung growth(GO:0060437)
0.0 0.2 GO:0045730 respiratory burst(GO:0045730)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.0 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.0 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.1 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.0 GO:1903053 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.2 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.0 GO:0045061 thymic T cell selection(GO:0045061)
0.0 0.1 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.0 0.0 GO:0001779 natural killer cell differentiation(GO:0001779)
0.0 0.0 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.0 GO:0035066 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.0 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.0 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.0 0.1 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.0 GO:0071636 positive regulation of transforming growth factor beta production(GO:0071636)
0.0 0.1 GO:0007350 blastoderm segmentation(GO:0007350)
0.0 0.0 GO:0002068 glandular epithelial cell development(GO:0002068)
0.0 0.0 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.0 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.0 0.0 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.1 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.0 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139) positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0 0.0 GO:0021780 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.0 GO:0032814 regulation of natural killer cell activation(GO:0032814)
0.0 0.0 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0002139 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.1 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.0 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.2 GO:0045495 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.0 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.0 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0031045 dense core granule(GO:0031045)
0.0 0.0 GO:0030891 VCB complex(GO:0030891)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.0 GO:0000800 lateral element(GO:0000800)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.1 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.0 GO:0042584 chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 0.2 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.1 0.2 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.0 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.0 GO:0019958 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.1 GO:0008518 reduced folate carrier activity(GO:0008518)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.0 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.0 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.0 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.0 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.1 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.0 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.0 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.1 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0008494 translation activator activity(GO:0008494)
0.0 0.0 GO:0004802 transketolase activity(GO:0004802)
0.0 0.0 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.0 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.0 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.0 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.0 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.0 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.0 0.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.0 GO:0060230 lipoprotein lipase activator activity(GO:0060230)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.0 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.8 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.0 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.0 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.3 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.0 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.0 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.1 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.0 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.0 REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.1 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.0 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.4 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.2 REACTOME BOTULINUM NEUROTOXICITY Genes involved in Botulinum neurotoxicity
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.2 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.0 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.0 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival