CREMA results: MAFF

Motif logo

Transcription factors associated with MAFF_MAFG

Gene Symbol	Gene ID	Gene Info
MAFF Ensembl NCBI GeneCards UniProt	ENSG00000185022.7	MAF bZIP transcription factor F
MAFG Ensembl NCBI GeneCards UniProt	ENSG00000197063.6	MAF bZIP transcription factor G

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Search:

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr17_79881653_79881920	MAFG	378	0.544473	0.22	5.8e-01	Click!
chr17_79882859_79883426	MAFG	1734	0.110119	-0.62	7.3e-02	Click!
chr17_79884017_79884248	MAFG	1452	0.130567	-0.37	3.3e-01	Click!
chr17_79884292_79884443	MAFG	1217	0.157577	-0.75	1.9e-02	Click!
chr17_79884635_79884786	MAFG	874	0.224290	-0.72	3.0e-02	Click!
chr22_38599321_38599536	MAFF	401	0.754404	-0.45	2.3e-01	Click!
chr22_38613940_38614323	MAFF	4589	0.130650	0.46	2.1e-01	Click!
chr22_38614387_38614538	MAFF	4920	0.127764	0.43	2.5e-01	Click!
chr22_38614803_38615828	MAFF	5773	0.122199	-0.45	2.3e-01	Click!
chr22_38616858_38617009	MAFF	7391	0.115580	-0.47	2.0e-01	Click!

Showing 1 to 10 of 10 entries

Activity of the MAFF_MAFG motif across conditions

Conditions sorted by the z-value of the MAFF_MAFG motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Search:

Show entries

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr8_23188811_23189024	1.05	LOXL2	lysyl oxidase-like 2	2091	0.26
chr10_134224918_134226015	1.03	PWWP2B	PWWP domain containing 2B	14764	0.17
chr3_137762283_137762711	0.97	DZIP1L	DAZ interacting zinc finger protein 1-like	23985	0.17
chr14_23316976_23317711	0.97	ENSG00000212335	.	4594	0.09
chr17_18124522_18124714	0.93	LLGL1	lethal giant larvae homolog 1 (Drosophila)	4283	0.13
chr2_43152306_43152732	0.91	HAAO	3-hydroxyanthranilate 3,4-dioxygenase	132787	0.05
chr8_121665009_121665299	0.90	RP11-713M15.1		108339	0.07
chr7_41476940_41477237	0.88	INHBA-AS1	INHBA antisense RNA 1	256426	0.02
chr1_22227763_22227914	0.87	HSPG2	heparan sulfate proteoglycan 2	5035	0.2
chr1_25041925_25042190	0.87	CLIC4	chloride intracellular channel 4	29791	0.15

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFF_MAFG

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.9	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.2	0.8	GO:0048149	behavioral response to ethanol(GO:0048149)
0.1	0.8	GO:0006108	malate metabolic process(GO:0006108)
0.1	0.7	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.2	0.6	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.2	0.6	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.2	0.6	GO:0010842	retina layer formation(GO:0010842)
0.1	0.6	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.2	0.5	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.5	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)

Showing 1 to 10 of 362 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	GO:0030016	myofibril(GO:0030016)
0.0	1.0	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1	0.8	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.8	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	0.7	GO:0001917	photoreceptor inner segment(GO:0001917)
0.2	0.6	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.6	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.6	GO:0005811	lipid particle(GO:0005811)
0.0	0.6	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.0	0.6	GO:0005604	basement membrane(GO:0005604)

Showing 1 to 10 of 97 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	1.0	GO:0017166	vinculin binding(GO:0017166)
0.0	1.0	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0	0.9	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.3	0.8	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.3	0.8	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.2	0.8	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.2	0.8	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.8	GO:0008009	chemokine activity(GO:0008009)
0.1	0.7	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)

Showing 1 to 10 of 238 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	1.7	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.1	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	1.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	0.9	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.6	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	0.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	0.5	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.4	PID WNT SIGNALING PATHWAY	Wnt signaling network

Showing 1 to 10 of 33 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	1.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.9	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.0	0.7	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.7	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	0.6	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.6	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.6	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.5	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.5	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway

Showing 1 to 10 of 58 entries

Results for MAFF_MAFG

Z-value: 2.59

Motif logo

Transcription factors associated with MAFF_MAFG

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the MAFF_MAFG motif across conditions

Conditions sorted by the z-value of the MAFF_MAFG motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFF_MAFG

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: